LOCUS       gnlProkkaMPDNKJEB_43   10614 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MPDNKJEB_43.
ACCESSION   gnlProkkaMPDNKJEB_43
VERSION     gnlProkkaMPDNKJEB_43
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 18:26:41
            Original ID  :: gnl|Prokka|MPDNKJEB_43
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10614
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10614
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1300:5614]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1301..5614
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10614
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10614
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             89..1237
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1301..2020
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.9e-17, bitscore:
                     52.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2041..3342
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2e-13, bitscore:
                     40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 8.4e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3359..4483
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.1e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.4e-21, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4493..5614
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.8e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg43_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_5"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-31, bitscore:
                     99.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     VCALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4583..5590
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_5_Aminotran_5.1"
                     /evalue="2.80E-34"
                     /label="ctg43_5_Aminotran_5.1"
                     /locus_tag="ctg43_5"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRVCALGEIEVDDIENFFKVLKAALNHY"
     CDS             5611..6084
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6081..7526
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_7"
                     /sec_met_domain="Polysacc_synt (E-value: 8.4e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7526..8248
                     /locus_tag="ctg43_8"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8262..9275
                     /locus_tag="ctg43_9"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9280..10239
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_10"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1e-42, bitscore:
                     135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 ttttaggtta tgctacttcc ttcagttctt tgggtatgat gattgcttct attgctaatc
       61 ttataaagaa ataatagaat ttacttttat gtcagaacaa cgacaggata aaaacttgct
      121 ctctgaacca cacaagacag aaagtgatga gatagaaatt gatttggtcg atatctttcg
      181 caagattatt gctattcgta aaaaattata caaagccgtt ggaattggtt ttattattgg
      241 aataattgta gcggtaagta tccctaaaca gtatacagta aaggttaccc tttctcctga
      301 aatgggtaat gcgaagggga gtaatggttt agccggactt gctgcctcgt ttttaggaga
      361 tggggctcta ataggggaaa gcacagatgc cttgaacgct tctctttcag cagatattgt
      421 ttcttcaact ccttttttat tggaactttt agaaatggaa gtctccgttt ctaaaaagga
      481 tgataaaatg actttggggt cttatctcga tgaagagtca tctccttggt gggattatct
      541 tataggtttt ccgggcatag taataggagg agttaaatca ttattcggag aagatacggt
      601 tcctgccagt ggagggcggc aaggaactat cgaattgacg aaagaagtaa atgagaagat
      661 taattttctt aaaaagaaga ttagtgcatc cattgataag aaaaccgcca taacgagcat
      721 tacggtcacc ttacaaaatc cgcagatcac tgcggttata gcagattctg tcgttcataa
      781 attacaggaa tatattattg ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt
      841 ggaacggttg tttaaagaac gtcagcagga atattatgct gctcaaagaa aatatgcgga
      901 ttatgtagac gcccatgata atgtggttct tcaaagtgta cgtgctgagc aggagcgttt
      961 acagaacgac atgagtttgg cttatcagat atatagtcag gttgctaatc agttgcaggt
     1021 atccagagcc aaagtacagg aggaaaagcc agtctttgca gtagttgagc ctgccgttgt
     1081 acctttgaaa ccttcaggta tgggactcaa aatttatatt ttattatttg tgttcctgtc
     1141 cgtatctggt actctcgtgt gggtgctttt tggcaaaagt ctgctggcta gcttgagaaa
     1201 agaactgaaa aataaggaga tagaacagga taaatgatgc taaaacgtcg tttacaacat
     1261 tcttacatca attaaattca cttactatat tattaaacga atgatacgta cagctatgat
     1321 aatggctgcg ggcatgggaa cccgttttgg ccaatataca gaattgatac ctaaagggtt
     1381 cgtcaaagtg ggaggtattc caatgatagt tcgttctatt gatactttgt tatcatgtgg
     1441 cattgagcga attgtaatcg gtacaggata taaacaagaa gtttatgaag aattgaagac
     1501 agactatcct atgcttgaaa cctgttttag tcctcgttat gctgaaacaa atagtatgta
     1561 tactttatat aatacgcggg agattctggg caatgatgat tttttattgt tagagtcaga
     1621 tttgattttt gagaaacaag caataatgag cttattggag tgtcctgcgg cagatgcaat
     1681 gctaataact ccagtgacaa agtttcaaga tcagtattat gtggaacatg atgataattt
     1741 tcgcctttct tcatgttctg tcaataagaa taaactaaac gctaaaggcg aattggtcgg
     1801 catccataaa ctatccggtt ccttttacaa aataatgtgt gctgattatg cgagtattgt
     1861 tgatgaacaa cccaatttgg gatatgagta tgaattacta cgaatatctt gttctcaatc
     1921 tcctgtttat gtgcataaag tagaagggct gaaatggtat gaaatcgatg acatatcaga
     1981 tttggaatat gcagagaaat atattgttcc gtattgttaa ttaaaataat atatcaaatt
     2041 atgagtaaga cagtttatat tgggatgact gcggatatta tgcatccagg acttatccgc
     2101 attattaatg aggctactaa atacggtgat gttataattg gtcttcttac agataaagct
     2161 attgcggagc ataaacgcct tccttatctg acctatgaac aacgaaaaga ggtagttcag
     2221 aatattaaag gcgtatgtaa agttgttcct caagaagaat ggagctatgt tgagaatctc
     2281 aaacgcatta aacctgacta tataattcat ggtgacgact ggaaaaccgg gcctttacgt
     2341 gaagaacgtg tgcgcgtatt tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt
     2401 ccatatactt tgggaattaa ttcatcttct ttggataaag atattaaggc tataggtaca
     2461 acccctgatg tacgtttaaa atcacttcgt cgtttgataa atgccaaacc cgtagttcgt
     2521 attttggaag ctcatgatgg actatgtggc ttgataattg aaaatcagga aatattaaaa
     2581 ggggataaga gggaagtatt tgacggaatg tggtctagta gccttacgga ttcaaccagt
     2641 aaaggtaaac ctgatattga ggcggttgat ttaactaccc gattgcaaga tttgaataat
     2701 attctggagt gtactactaa acctattatt tttgatggag atacaggtgg taaaattgaa
     2761 catttcgtat ttacagtacg cactttagaa cgtcatggaa tctcagctat aataattgaa
     2821 gataaagttg gattaaaaaa gaattcattg tttggtacgg atgttattca aactcaagat
     2881 acaatcgaag gtttctgtaa taagatcaaa gcaggaaagg catctcagat tactgatgat
     2941 tttatgatta tcgctcgtat tgagagcctt atagcgggaa agccggtaag tgatgcttta
     3001 gagagagctt ttgcatatgt ccaagcggga gcggacggta ttatgataca tagcaaaaat
     3061 aagtcgggtg aagatataaa agaattttgt ttggcgtttc gaaaacagta tgctcatgta
     3121 cctatcgtgg ttgtgcctac tacatatgat catatttatg agtctgaatt gtgtgattgg
     3181 ggtgtgaata taattattta tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg
     3241 aatgtcgcaa agacaatatt agagaatgaa cgtgctttag aggtgcgcga actgtgtatg
     3301 cccataaagg aaatattgga actgattccg ggtactaaat aaaaagagga atatcattat
     3361 gttaagcgta gaaaaagttt atgaaacgtt tctgagtcat gacgttgatt tttttacagg
     3421 agttccagac tcattactaa aaaatatttg tgcctatatc acagaccata cttcacgtga
     3481 gaaacatatc atagctgcta atgaaggtgc ggctgtagga attgcttcag gttattatat
     3541 ggcatcaggt aaggttcctg tggtttatat gcaaaattcc ggcttgggta atactgttaa
     3601 tcctctgctg tctcttgcag atgaacaagt atacagtttt ccaatgcttt tgatgattgg
     3661 ctggcgtggt gaaccgggaa caaaagatga acctcagcat aaaaaacagg gtgaggtaac
     3721 tttagatttg ttgaaagcaa tgcggattcc ttatataatt cttgattcaa atgagaatga
     3781 tgcatttatt cagctccatg atatcataca atcagcaaaa actaagaata ttcctcatgc
     3841 aataattatt cggaaagatg tttttggcaa atataaactt caaaaagagt tcggatgtaa
     3901 ttatccttta tctcgtgagg atgctttgca aatagttgtg gattatctgc ctgaaaattc
     3961 agtggtcgtt tctactactg gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa
     4021 agagcaaggt catgaacatg attttctcac ggtaggctct atgggacata gttcatcaat
     4081 ctctttgggt attgctatag caaagcaaga tagacctgtt tattgcttgg atggtgatgg
     4141 agcatttatt atgcatttag gggcaattag taacattggc gatttatctc ctaaaaacta
     4201 ttatcatatt ttgtttaaca atggtgctca cgagtctgta ggaggacagc ctactttagg
     4261 atttagttta gatattccgg ctattgtccg ggggagcgga tataagcata cttatactgt
     4321 ttgtacaaaa gttgaaattg aagaagcaat gaagcagctt ccaaagttat gtggtcctgt
     4381 tttgttggaa ataaaggtta aaatagattc tcgggagaat ttgggacgtc ccacgactac
     4441 tcctatagag aataaggagc attttatgga ttttttaaaa taaatatatt cgatgaaaat
     4501 agaaagaaaa atattattaa atcctgggcc tgccactact actgacagtg taaaaatggc
     4561 acaagttgtt ccggatattt gtcctcgcga gaaagaattc gcaggtatga tgaaacaact
     4621 tcgggacgat ttggtcagag ttgctcatgg gaatttggaa aaacataccg ctgtattatt
     4681 ttgtggctca ggaaccatca atattgatat atgtctaaat tctcttcttc ctgaagacaa
     4741 aagggtgctt atagtgaata atggggcata tagtacccgt gctgtagaag tgtgtcaata
     4801 ttatggtttg cctcatatta atttggaatt ttccgtttac gaacgtcctg atttatcggt
     4861 ggtggaaaat gtgttgcaag aaaatcctga tatagctatg gtttatacta ctcatcacga
     4921 gacgggtaca ggaattctga accctattcg cgagatgggc gctatagctc ataaatatca
     4981 ggctaaattt gtcgtcgata ctacttcttc tttgggcatg attccttttg atatagagaa
     5041 agataatgtg gatttttgta tggcatctgc tcaaaaagga cttcaagcga tgacaggtct
     5101 ttcttttatt ataggcaatg aggaacagat taagttttca aaaaaatatc ccaagcgttc
     5161 ttactattgt aatctttatt tgcagtatga gaattttgag agaacaggtg aaatgcattt
     5221 tactccaccg gtacaaacta tttacgccac tcgtcaggca ttaaatgaat attttgaagt
     5281 gggcgaagaa gctaagtttg cccgtcacaa aagagttttt gaggctattc attcaggtat
     5341 aaatgaaatt ggtcttaaaa gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc
     5401 agttcaatac ccagaagatc ccaactggga ttttgagaaa atacatgatt attgttatga
     5461 gcgtggattt acgatttatc caggtaagat atcaactgag gatactttta gagtctgtgc
     5521 tttaggagag atagaagtag atgatattga gaacttcttt aaagtactaa aagctgcatt
     5581 aaatcattat aacgtcacat taccgatgtc atgattgcag aaatattatt gaagattcgt
     5641 catttttatt tttcccttcg tggtatacac ttccatccgg aaagtgttat ttctggagtg
     5701 cctattcgta gctttcgctt agtaggcaaa tatagcaata tctacttagg taaaaatgct
     5761 gaaatacgtt caggctgtta tctgattgct cgtgataaaa tcattattgg agaaaactca
     5821 acactcgcct atggaacgac tatattgaca actgctgatc ctaatggacc gtataatgca
     5881 ttagcagttc tttatcctta taaaaaggca ccggtagtta taggagataa tgtttggatt
     5941 ggggctaatg ttaccatcct tcctggagta actattggtg attacgttgt agtagcagct
     6001 ggagctgttg taacaaaaga tgtaccttca ggagtattgg tagctggtgt accagctatt
     6061 gtgaaaaaac gttttaataa atgaaagaaa aaacttcttt aaagaacaaa gccatatgtg
     6121 gaatcttttg gagtgcagtt gaacgatttt tatcacaggg gatacagttt gtagttacag
     6181 tcattatggc gcgttttcta ttgccatctg attatggaat ggtaggaatg ttagcaatag
     6241 ttcttcaatt atctcaaacg ttaatggata gtggttttac taatgccctt attcgttata
     6301 aggaacgtac tgaaattgat tattcaacag ttttcttttt taatatatta gcatcattag
     6361 ttatttattt tctaattttt tttctagctc cttatatatc gtggttttat aaaataggtc
     6421 aattagttga gattactaga attttatcta ttgttattgt tttaaattcc tttgcgatta
     6481 ttcctaaaac taaattaata atagctgtag attttaaaac tcaatcaaaa gtctcattta
     6541 ttgcagcttt ggtttcaggt attattggca tttgggctgc atatttagat tttggagttt
     6601 gggctttagt tggacaaact ttagtaaacg gattgttgat tgtagttttg tatgcatatt
     6661 tttgtagatg gaaaccattg tggatatttt cattgaaatc gtttcgttta ttatttgctt
     6721 ttgggtcaaa attagtatta gctaatattc ttaatacttt atataaaaat ctgtatgcta
     6781 tagttatagg aaagaagttt tcgtcggttg atttaggatt ttatactcgt gcggaacaat
     6841 ttgctcagtt tccttcatat aatttgagtg caataatttc tagagtgaca taccccatat
     6901 tgagccttgt gcaaaatgat aatgatagat tatctgcttt atataggaaa tatgtccgtt
     6961 tatcttctgc ttttatcttt ccattgatga ttttgttaat tgtcatagct cagccactgg
     7021 tattattgct tttgacagaa aaatggatag gagtagttgt attgcttcaa atattgtgtt
     7081 tagattggat gtttgatcat ttgagtagta taaatttgaa tttactatat gtaaagggac
     7141 gttcagactt ggctttacgt ttagaagtta taaaaaaagt gttagcgacg gggatccttc
     7201 ttctatctat tccttggggg attgtaggta tgtgttgggg gcgtgttatg tattcattga
     7261 ttgctgtgta tttgaatact tattatacag aatcattgat taaattaagt cttattagac
     7321 agatgagaga tatactacca agcttttttt tagcattaat aatgggagga ggtacttggt
     7381 atatgatttt attgttagag ggtgaaattg ttcaaattgt agtaggaagt gttattgctt
     7441 tattgctata tggaacgttg ttgtattgct tttctcgatc cttgtttgat gaaatatggg
     7501 cggttatatt aaaaataaaa aggtaatgga taaactgagt ttgattatta gtaaaatacg
     7561 acggaatcat tggtatagaa cctatatgcg tcctatatat ttatttgttt atggcaatag
     7621 aaaattgaag aatagaaata gaatattttt gcagtattca caagagctgc taactaactt
     7681 tcatcaagca atgaatgaag tgggaattcc ttattggtta gaatttggaa ctcttttagg
     7741 tgctgttaga gaacacagtt ttataagtca tgattttgat cttgatgtgg gcctttttaa
     7801 ggaagattat tcagatataa taagagaggt cttaaaaaaa tatggtttca aaagaataag
     7861 gtgtataacc gcccttgatt ttattgatgc ttatgaggaa acttatcttt ataaaggtgt
     7921 gacaattgat cttttccttt tttcaagaga gaaaaattgt gatggggtct attgttatga
     7981 ttttgttcca gtatattcag atataaagag aactaaaaaa ggtgataatg caatccggag
     8041 aattcatttt cctagaattg atttgattga atattcattt attggaatta atacttttgt
     8101 tcctgaaaat tatgaggaac atctttgtat gcattatggt aaagactata tgattccaaa
     8161 tcctcattgg aaagattcag atgcgcaaca tactgatatc ttttatggta gagagattag
     8221 aattgaattg tttgataaaa gtaaataata gtagataata catgttctat ctattttttt
     8281 tactaattgt gctatttttg ttatatatac aaagtaggaa aagacaatat tctactgtag
     8341 cgggaatttg tgttcctatt attataattt ttgttgtaat ttgtcgttat agagtggggt
     8401 atgactattt aacgtattat acattaattg aaaatgaaga agaggcacag attttatact
     8461 tattttctcc tttaagcatt gtttgggcag agattgcttt atattttgaa tctccacaga
     8521 tgttatttgt tctttttggg cttccaacat ttgctcttct aatatttact ttaaaaaaat
     8581 attcaaaaga ttatgcgtta tcagtaacta ttttaatttg tttcttcttt tttacatcac
     8641 tcagtattat tcgacaagct ttggctttgg ctatttgttt ttatggttat cgttttatag
     8701 taaaacgttc actaattaaa tatatattat gtatattgat tgcagcttta ttccatcctt
     8761 ctgcaggagt agcgattatt atatattggt tgccatttct aaagtttaga ttagttgtat
     8821 tattatctat aatatcaata gtagccaaac ctttattttt ttatatgcta aatatattag
     8881 gggtgtatac ctcttatctt gatggcaaga tggatattga aggtgggaaa tatactcaat
     8941 taatatactt tttgttgttt attatttgtt ttgttttggg aagtaaaaac atagataaaa
     9001 acaagtgtaa tttatttaat gttttattgt taagttttgt tttcgtatct tttttaggag
     9061 ctcatttagg cgggagaata gcgttttatt ttaatatata ttattgtttg ttgattccta
     9121 aagtggttaa aggattggat gggcaactaa gagagcaagt gaagcttctt tcttattttc
     9181 tatgtatttc ttatttctta ttgtacctat tcgttccatt cataaaaggt gtaccctcat
     9241 attatatccc atataagttt atatttttca aatagtaaaa tgttgatatc tataattgtc
     9301 ccttgttata attctgaaag atatttgtct gattgtttat tgtctatatt gaatcaaacc
     9361 tatgttaatt gggaggtgat ttgtatagat gatggaagtc aagataatac attatctatt
     9421 ttaaatcatt acgctacatt ggatgagcgt tttaaaatta tttctcagtc taatgcagga
     9481 gtgtctgtcg caagaaataa ggctctatcc cagtgtcaag gagagtatat ttgctttgtt
     9541 gatagtgatg acctgataga acctaatttt ttgataacac ttttacagct tataagtcat
     9601 caggctgatt tggcaatctg tggttttact cgttctatgg ttttctgtat ggatgatgct
     9661 caaggatata tagaaatgag tggtaaacgt tgtatagaaa gaattattct agataaaagt
     9721 ttcaatcctc agatttgttg tatgttattt cgacataata ttataaaaga gaaacaatta
     9781 gaatttgtga tagggtgtac tcgtggtgaa gatcgtgaat ttatattgaa atatttagtt
     9841 tattctaata aggtttgtta tacaaacaat cttctttatc actatcgtgt aaatgatcag
     9901 tcagccatgg caatcttttc tattaaaagt ttgacaagta tagaagcttc acaacgcacg
     9961 gtcaactact ataaaaaagt gaattattct gttagagggc ttgaatttga attttcacgt
    10021 acattgtgga aattcatgat tttagctatt ttgtctgggc aaaatgattt atatcaaatc
    10081 attcgagaaa agtatgatct aaaaagacaa atggaacatc tttattctca tccaggacta
    10141 tccgaaaaac ttacagcgag attgtttgtt tggaatgagg cactttttaa atgggtattt
    10201 tctattatta gatatctata taaaaaaaga tggagatgaa taaacgaaat agattatctg
    10261 aacaagaaat aaaaaaagta gaacttgacg ctttattgta tattcggaaa atttgtcagc
    10321 aatatcatct tcgctattat ttagcttggg gtactttgtt gggagccgtt aggcataaag
    10381 gatttattcc ttgggatgat gatattgata taatgatgcc acgttcagat tatgagcgat
    10441 tattggagtt agttccttcc ttgagacata gttattataa aatcttaagt aatccaaaga
    10501 atgaggatta ttattatact catgcaaaaa tgatagatac tcgtactttg tgtgtggaaa
    10561 atgatttgca aactattcaa aatatgggga tttgggttga tattttcccc ttag
//
