LOCUS       c00069_gnlPro..        13744 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HEBNBDMG_69.
ACCESSION   c00069_gnlPro..
VERSION     c00069_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:54:20
            Original ID  :: gnl|Prokka|HEBNBDMG_69
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13744
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13744
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3744]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3744
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13744
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13744
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..266)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_1"
                     /sec_met_domain="OAD_beta (E-value: 4.7e-16, bitscore:
                     49.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQ"
     CDS             complement(269..700)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 69.7; E-value:
                     4.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3e-22, bitscore:
                     69.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKRGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             complement(726..1640)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_3"
                     /sec_met_domain="OAD_gamma (E-value: 4.8e-16, bitscore:
                     50.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     VAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             complement(1661..3214)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_4"
                     /sec_met_domain="CT_Btheta (E-value: 7.7e-291, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(3340..3744)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 8.1e-24, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             4146..4880
                     /locus_tag="ctg69_6"
                     /transl_table=11
                     /translation="MGIPEGFPYSQYTRVLQGIGFPHTSRKPEIGIVSRIDTGRASDNF
                     VFVANDENLCLPAVNQPGVHVLEKDDVGKMFTDAGRIEMPQHIRKFAYLFYRTCLVYFC
                     SIFQAFFDLADTGGAETLFGVFDAVKRVSYPQPVDREVSVGPEIFVAEHGVLQIAEFYQ
                     KRVPQSLRGEVLQHFAEYPFLVGFRCQIFARAIDFAAFDESGRKHADAFADGSKQSRNG
                     FSVFRSHNQEWGVARSFFVDLK"
     CDS             5079..5621
                     /locus_tag="ctg69_7"
                     /transl_table=11
                     /translation="MLEEILEFNKKFVENRGYEKYITNKYPDKKIAILSCMDTRLTELL
                     PAALGIHNGDVKIIKNAGAVISHPFGSVIRSLLVAIIELGVEEVMVIAHSDCGACHMNS
                     DEMIAHMKKRGIKSETIDMIRYCGVDFNSWLGGFDDPVKSVRGTVRSIENHPLIPKDVR
                     VHGFIIDSLTGELTRVE"
     CDS             5827..6324
                     /locus_tag="ctg69_8"
                     /transl_table=11
                     /translation="MRKFTGEELSQEDVVALLKAALMAPTSKRSNSWQFIAVDDKKLLG
                     ELSHCKEQASAFIADAALAIVVTADPLASDVWIEDASIASIMIQLQAEDLGLGSCWVQV
                     RERYTATGMPSDEFVRGVLDIPLQLQVLSVIAIGHKGMERKPFNEDHLQWEKIHINKFG
                     GK"
     CDS             6327..6659
                     /locus_tag="ctg69_9"
                     /transl_table=11
                     /translation="VSAVKANNKDTYKATAVTLIVMGVLYLIDKLIHFSTLGIPWVMNK
                     DNLLLYTAVIFLFIKRDKSVGLVLLGLWLVLNIGLIVSLLGSMSGYLLPLALLIIGGIL
                     YLISTR"
     CDS             6656..7447
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_10"
                     /sec_met_domain="F420_oxidored (E-value: 6.1e-14, bitscore:
                     43.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTEESAR
                     ELAQKVEAEYTTDLAEVNPYAKLYIVSLKDSAFAELLQGIVEGKREEALMVHTAGSIPM
                     NVWEGHVSHYGVFYPMQTFSKQREVDFKEIPFFIEASSTEDAAFLKAIASTLSNRVYDA
                     DSEQRKSLHLAAVFTCNFTNHMYALAAELLKKYNLPFDVMLPLIDETARKVHELEPKTA
                     QTGPAIRYDENVIGNHLRMLADDPAMQRLYELLSRSIHERQ"
     CDS             7468..7989
                     /locus_tag="ctg69_11"
                     /transl_table=11
                     /translation="MSTINYDLTRIKALAFDVDGVLSANVIPLHPSGEPMRTVNVKDGY
                     AIQLAVKKGLRIAIITGGRSDVVRKRFIGLGVSDLYFGSAVKIHDYRGFRDKHGLTDEE
                     ILYMGDDVPDMEVMRECGLPCCPKDAVPEVKAIARYISYADGGYGCGRDVVEQVLKAQG
                     QWLSDDAFGW"
     CDS             7973..8602
                     /locus_tag="ctg69_12"
                     /transl_table=11
                     /translation="MLSDGDFQYIPYLFISMLANLDRYKIVLASNSPRRKELMTGLGVD
                     YVVKTLPDVDESYPDTLQGEEIPLFIAREKAAAYQSMIGPEELLITADTIVWHEGKALG
                     KPVGRQDAIEMLRSLSGKSHQVITGVCLTTREWQKCFAAVTDVRFAILDEDEIAYYVDH
                     YQPMDKAGSYGVQEWIGFVGVESISGSYFNVMGLPIQKLYRELKQL"
     CDS             complement(8795..9187)
                     /locus_tag="ctg69_13"
                     /transl_table=11
                     /translation="MKKILLLLSVCISFSSCCTLFSSSKQDITFTGMNGTKIYEASTKQ
                     KIAEIKEDNSVTVQIKKKREDKQLVAKKEGYQTTPFVLESTFNNACLWNILFWPGFLVD
                     LGTQKMNKWDNTIINIEMEKENTENK"
     CDS             complement(9292..10332)
                     /locus_tag="ctg69_14"
                     /transl_table=11
                     /translation="MLHHSSRISPKTRFCLKLLLLILPLIPIVVVYFMFDPYRVLHPYK
                     RFDDSPMLLNEAHVGWQNYLQNRDSIAYNSFILGNSCTMAFLTGEWEKYLDKNDHAVRF
                     YDNGESLGGVRQKLQLLDSVGAPLKNILIVLDKKSLDKNAPLSGNNHLFSAEAAGISQL
                     GFQLRFLQEFLYPDRMIPYIDYLIRHKYAPYMKGVINPGDPVREPYTNNFINPREKEIA
                     QDGEIYWSRHEKEFKKRTNAGMEELPVIFASQIQVLRSIKKICDKHHTNLKFVIGPDYY
                     QKKASREDIKILKAILGNSAVWDFTGINEYTADIHHYYEPGHYRPLLGARLLKAIYQDQ
                     DTCHRQ"
     CDS             complement(10351..11733)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MBOAT"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_15"
                     /sec_met_domain="MBOAT (E-value: 1.5e-21, bitscore: 68.3,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFLSFSFLALFTLCFFLYYAVKGRARNLILLVTSCIFIGWYYLP
                     FLLTAVVVALFTFFWAQWMESRAKAGKKTKPVYIAGIIALIGGWLLLHGTVIDDIIFPL
                     GMSFYTFQAISYLTDVYWQEQRSERNWVDFLIYMLFFMKFLSGPIERGGDLLPQLKDPR
                     PFIYSNAVTGLKYILLGLIKKLLIANQISPQTDVMFHSIHDLSGVQLLMTCLLYPIELY
                     ADFSGYTDIAIGGAYMFGIKLSPNFNRPFAARSTADFWRRWHMSLSFWVRDYLYVPLTA
                     GTRNWGQWGIYFSLLITFLALGLWHGAGLTFAIYGLIQGVLICWEMKTAAFCYNLPQYI
                     GKYAADSLLIVRTYLLFALSLIFFRVQSLSDAWYFLRNISFEVHSSWKEMNIGIRDHNC
                     IVAGSALLLVLIYEYYASKYNLMETLERQPAWLRWSVYYLLVFALLMLGKFDTETFIYL
                     QF"
     CDS             complement(11737..11979)
                     /locus_tag="ctg69_16"
                     /transl_table=11
                     /translation="MNREEVLKQLQSIFRDILKKDNVCIDESSTSKDVDGWDSLTHMQI
                     IAQIEKHFGVRFNFREVIKFKNVGDLCSALLTKME"
     CDS             complement(11994..13508)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 267.1; E-value:
                     7.1e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_17"
                     /sec_met_domain="AMP-binding (E-value: 4.4e-82, bitscore:
                     267.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSPQKDIINDILSAMQCYPENEAFIIDDKHYTYAQLGEITASI
                     THSLSEIKDERIGIVAENRIETYAAILAVLAGGKTYVILHPAYPKERNLKIAALAGLRT
                     LLCTSDTDRSAFGTGHFRIIDTDRLPGKALSEQQSHSSDEERNAYIIFTSGSTGEPKGV
                     PITRANLNAFYRAYSSLDWNLDEHDRMLQMFELTFDVSVVSLLYPLTLGAAVYTVGHQD
                     VKHFKVFELLEKYELTFATVTPSLLQLLSPYFDEINLPSLKYLGVSAEASQTELLERFR
                     KSAPNATFINLYGPTEATIYCTCYRIPASDKCKHYNGMVAIGKPFPGIRAIIADEEGNE
                     LPQGETGELWVSGRQVMKGYLDDPEKSTLVLIHRPDGQIYYRTGDLCILDSDGDIIYCG
                     RKDYQVKIQGFRIELSEIEYTAQSFFKTPCSVAAVPLLCDGICNELHLAVETTECTQSA
                     LIEYLKEKLPKYMLPKQIHCISQFPVTNSNKTDRKKIAELIKEKKL"
ORIGIN
        1 ccttgataaa ggatgttcag taccgaacct tcttcgtaaa tacccacttt taatccggct
       61 tccatattga atggaatatt accgatcaga ataccgaagc caatggggat cagcagcatc
      121 ggttcaaatt ctttggctac ggcaaggtag ataaagaaga gaccgattag caacatgaaa
      181 agatgtccgg gtgtcgcgtt cgcaaaaccg gtgtatcccc agaagtcaac aaggttattc
      241 cctaagaatg atacgaaatc tcccataatt attcaatgat tacgaggtct gtaccttcaa
      301 gtacagaatc tcctttatta actttaattt ctgctacttt tccgtcttta ttggcattga
      361 tgttgttttc catcttcata gcctcaagga tgatgatcgt ctggcctctc ttcacggtat
      421 ccccttcttt cacttttatg tcgagaataa cgcccggaag tggagatttc acaccgtctt
      481 ttttggaagc tgtcggttgt ttggttacta ccggagcgcc tgtttccgtt ttcggagcgg
      541 ctgccggacg ggtcaccggt ttcggagcgg ctttgacggg cttgtccaac tctactttat
      601 aagaggttcc gttcacttca acgttggcta tgttatcttc tacatcgttc actgtaacgt
      661 tgtaaaggtt gccgttgatt ttatatttat attgtttcat tgcttcattt tattagggtt
      721 agtaattatc ttttcggagt ctgacgcagt gtgtagatct tcgaactcca gggtgagtag
      781 gtgcgtttca ctttgttgat ggtcaaaatc atgtcttcaa cgtcgtgagc gtcattcagg
      841 tattcatgca aagccatggc gattgcggcg gtttcttcac ctgtgtggct acccaggttc
      901 ttttccttcg cttccgtctt gtcggtgata ccggtggctt tcatcgcgtt tttcttaccc
      961 aatctgacag ctacgttacc taccgccttg aatgaaagat acaagagtac caaacctatg
     1021 aatacgaccg acatggcgat gatggccata ccgataccga tagagtcgtg tttcttgaag
     1081 ttctcgatct tcgggttttt gtcgatagtc atattgttgg tgctcggagt gacatagctg
     1141 tgttctcctt caccttttac tacccagttg gcacttccgt ctttttcgcg agcgtatgaa
     1201 cggtcggcaa gctgaccggc gggtatggtt acttcgtcaa tcagagtttt accgttagag
     1261 tcatacaaag caatgtaatt ctctttgttc gggtcgagcg taaagttcac gtggaacgta
     1321 ccccggttag gcattccgtc tgcccagaac aaagcatgtt ggcgcggctt gatcagagtc
     1381 agcacgtcgc ctttgggaat aggatatttg gtcggattgt ttttatcgtt cgtcagaaag
     1441 caaccttcca gatttacaga agcgaaagag gtgttgaata tctctatcca cgcattgtgc
     1501 agtccgtagt catcctgata gttctggtcg ttgacgacca aaacctcatt gattctcaga
     1561 ctggtggcac tttgcgccct gagccccatg caaaccattg ccagcagagc gataaatatc
     1621 ccgattcttt tcttattcat aacaatcgat gtttaatttg ttacaatgga atattaccgt
     1681 gctttttagc agggttggtt aattttttgg tctgcagctg ttgcagggcg cggatcacgc
     1741 ggaaacgagt gtttctcggt tcgataacat cgtcaatgta accgtatttg gctgcattgt
     1801 acgggttggc gaacagttta gtgtactcgg cttccttgtc tgccaggaat tgagcagggt
     1861 tttcctgatc tttggcttct ttggcataca ataccgctac tgcaccggca ccgcccatta
     1921 cggcgatttc ggctgtcggc catgcatagt tcatgtcgcc gcggagttgc ttgcaactca
     1981 ttacgatgtg cgaaccaccg taagatttac gcagggtaac agttaccttg ggcacagtgg
     2041 cttcaccata agcgtacagc aacttggctc cgtgcaggat tacaccatta tattcctgac
     2101 ccgtacctgg aaggaatccc ggaacgtcta ccaatgtcac cagcggaatg ttgaatgcgt
     2161 cgcagaagcg aacgaagcgt gcacctttgc gtgaagcatt gctgtcgagt actccggcga
     2221 ggtatttagg ctgattggca accacaccta ccgattgtcc gttcatacgg gcaaaaccga
     2281 taataagatt ttttgcataa tctttctgta cttccaggaa ttctccgtta tcgatgatgg
     2341 cgccgatcac ttcgtacata tcgtacggtt tgttcgggct gtcggggatg atctcgttca
     2401 gcaggtcgtc catacggtcg atggggtcgg tacagttcac caatggagct tcttccaggt
     2461 tgttttgcgg aataaagctg agaagcttgc gaataatcgc cagaccttct tcaccggttt
     2521 cggcagtgaa gtgagttaca ccggacttgc tggcatgtac gcttgcacca cccagatctt
     2581 cctgagacac gtcttcaccc gttactgttt tcacaacagc cggtccggtg aggaacatgt
     2641 aagatgtacc ttccgtcatc agcgtgaagt ccgtcagggc gggagagtaa accgcaccgc
     2701 cggcacacgg accgaaaata cctgaaatct gtgggatgac acccgaagcc atgatgttgc
     2761 gctggaagat ttcagcataa ccggacaggg cgttgatgcc ttcctgaata cgtgcgccac
     2821 ccgagtcgtt gataccgata acaggggcac ccatcttcat ggccatatcc attactttac
     2881 agatcttttg tgccatggtt tccgacagtg aaccaccgaa tactgtgaaa tcttgtgcga
     2941 aaacatatac taatctacct tctatcgttc cataaccggt taccacaccg tcgccgagga
     3001 aatgtttttt ctcttgtccg aaattggtac atctgtgttg aacaaacata tccagttctt
     3061 cgaaactacc ttcgtcaagc aactgtgcaa tacgctcgcg ggctgtatat ttgcctttgg
     3121 cgtgttgttt ttcaatagcc ttttcgccac cacctaaacg agcctgagca cgaagttcaa
     3181 taagctcttt tactttttca agctggttac tcatgagttt ttcttaattt aaagggttat
     3241 aatatttaca accggacgat tgacaacccg gatggggaat ttaatgtaaa gaaaaattcc
     3301 gtttgtccgt ggcgcggatc gtccgaatcg tacatctttt tagtgttcgc agagttctgt
     3361 cagtacgccc agagttgatt tcgggtgaag gaaagcaatg ttcaggcctt cggcaccttt
     3421 gcgcggagct ttgtcgatca ggcggatctc tttgctttcg gcttcggcca gggcattggc
     3481 tacgccgtct tcaatggcga atgctacgtg atgaacacct gcacctttgt tttcgatgaa
     3541 tttcgcgatg gtactttccg gacatgtggg ttccagtaat tcgattttgg tatcacctac
     3601 tttcagaaag gctgttctta ctttttgatc ttctacagtt tcgatgttgt agcatttcaa
     3661 acctaaaacg ttttcataat acggaagggc ttcttcgata ctttttacgg caatgcccaa
     3721 atgttcaatg tgtgaaatct tcataactat atttttaaat tttggtatta atcgtctttt
     3781 cggaatggta taaaacagca caaagaaaat caattcttgt ttaataaaga aatttttctg
     3841 caattaatta tggtgaaaat aggtttaaaa cctaaggtgc atgggtttaa aaggcaggca
     3901 tcgttggttt aaaacctaag gggtgttggt ttaaaaggcg gagagggttg gcgctgatcc
     3961 ctgagacagg cggatgttca gacgtatatt ttgatcagca ggtcgttcag ccattgccag
     4021 cggaaacgga accatcgccg ggtgctgctt tgcttgccac cgaagcggag cacgaagtca
     4081 cgataaccgt gcttcttaaa tgggagtccg acgtccatga actccatgtg gcggaatccg
     4141 ttttgatggg catcccggag ggctttccat acagccagta tacccgggta ttgcaaggca
     4201 taggttttcc gcatacctcc cgaaaaccag agataggcat cgtttcccga atagatacag
     4261 gcagagcctc cgataatttt gtctttgtag cgaacgatga aaatctttgc ctgccggctg
     4321 tgaatcagcc gggtgtccat gtgctggaaa aagatgatgt tgggaaaatg tttacggatg
     4381 cgggacgaat agagatgcct cagcatattc gaaaattcgc gtatctcttc taccgtacgt
     4441 gcctcgtcta cttttgctcc atttttcagg ccttttttga tctggcggat acgggagggg
     4501 ctgaaacgct gttcggtgtt ttcgatgccg tgaagcgagt ttcgtacccg cagccagttg
     4561 acagggaagt atctgttgga ccggaaatat ttgtagccga acatggcgtt ctccagattg
     4621 cggaattcta tcagaaacga gttccgcaaa gcctccgtgg tgaggtgctc cagcatttcg
     4681 ccgaatatcc tttccttgtc ggcttccgct gtcagatatt cgcccgtgcc atagatttcg
     4741 cagcgtttga tgaaagcggg aggaaacatg cggatgcttt tgcggatggc agcaagcagt
     4801 cgcgcaacgg gttttccgtc ttccgaagcc ataatcagga gtggggtgta gcccggagtt
     4861 tcttcgtaga tctgaaatag ctctttcgaa tgaaacgtat tggttccggg aaaatccgga
     4921 atctcacttc cttggtaata tgtagtcagt tttaatggca tatcgggaca aatttacatt
     4981 ttttatttct ctttacaaca tttgcagggc ttattttgtt gagctgtcgt tttgtgacta
     5041 tctttgtgga gatactacaa taaaatccgt ttttgattat gttagaagaa attcttgaat
     5101 tcaacaaaaa gttcgttgag aacaggggat acgaaaagta tatcactaac aagtatcctg
     5161 ataagaaaat cgccatcctt tcctgtatgg atacccgcct gacagaactg ttgcccgccg
     5221 ctttggggat tcacaacgga gacgtaaaga ttataaagaa tgccggtgcc gtcatttccc
     5281 atcctttcgg cagtgtcatc cgtagtctgc tggtggctat catcgagttg ggagtagaag
     5341 aagtgatggt cattgcccat tccgattgcg gtgcttgcca catgaacagc gacgaaatga
     5401 tagctcacat gaaaaagcgg ggaatcaagt ccgaaacaat cgacatgata cgctactgcg
     5461 gggtcgattt taattcgtgg ctaggcggat tcgacgatcc ggtgaagtcc gtcaggggca
     5521 cggttcgttc catagagaac catccgctta ttccgaaaga tgtccgggtg catggtttta
     5581 tcatcgattc actgaccggc gagttgacga gagtggaata aattgcctat ctttgcgctc
     5641 gaatcgccac ggagcgcgcc gattcatgca aagtcctgca gggcatacct tatatagacg
     5701 ggcatgccgg gtggtacctc ggtttgcgtg tgtttgtgca ttctatggtg actggcggta
     5761 tattcaaata atgcaaagta tagatacatg gaaaatttca gtgaactaat aaaaaatcgc
     5821 cgcagcatgc ggaaatttac cggagaagaa ctttctcagg aagatgtagt cgctttgctg
     5881 aaagcggccc tgatggctcc tacttcaaag cgcagtaaca gctggcagtt tatcgcagtc
     5941 gatgataaaa agttgctcgg tgaactttca cattgcaaag agcaggcttc ggcctttatt
     6001 gccgatgcgg ctttggccat tgtcgttact gccgatccct tggcgagcga tgtatggatt
     6061 gaggacgctt ccattgcctc tattatgatt cagcttcaag ccgaagactt ggggttggga
     6121 agttgctggg tgcaggtgcg tgagcgatat actgccaccg ggatgccttc cgatgaattt
     6181 gtgcgcggtg tgctcgacat tcctttgcag ttgcaggtgt tgtccgtcat agcgatcggg
     6241 cataagggga tggaacgtaa accctttaat gaagaccatt tgcaatggga aaaaatccat
     6301 attaataagt tcggaggtaa gtaacggtga gtgcggtaaa agcaaacaat aaagatacct
     6361 acaaagccac ggcagtcacc cttattgtga tgggggtgct ctatctgatc gacaaactga
     6421 tacacttttc cactttgggg ataccctggg tgatgaataa ggataatctt ttgctttaca
     6481 ctgcggtgat tttcctgttt attaagcggg ataaatccgt cggcttggta ttgctcggat
     6541 tgtggttggt gctgaacatc ggcctgattg tttcgttgct tggttcgatg tccggttatc
     6601 tgctgccttt ggctttattg ataatcggag gtatattgta tttgatttca acacgatgaa
     6661 aagaagtata gaagatacgc cgatcgtatt tatcggtgcc ggaaatcttg ccactaatct
     6721 ggcaaaagcc ttatatcgga aaggttttcg tatcgtacag gtgtatagcc gtacggaaga
     6781 gtcggcccgc gagctggcac agaaagtgga agccgaatat acgacagacc tcgcagaggt
     6841 gaacccgtat gcgaagctgt atattgtttc actgaaagat tccgcctttg ccgaacttct
     6901 tcagggcatt gtcgaaggta agcgggaaga ggcattgatg gtgcatacgg caggtagcat
     6961 cccgatgaat gtctgggaag gacatgtctc gcattacggt gtgttctatc ccatgcagac
     7021 tttcagcaag cagagggagg tagattttaa ggagattcct ttcttcatag aggcttcttc
     7081 gacagaagat gccgcgtttc tgaaagccat tgcctctaca ctgtccaacc gtgtgtacga
     7141 tgccgactcg gagcagcgta aaagtctcca cctggctgcc gtgtttacat gtaatttcac
     7201 caatcacatg tatgcccttg ctgccgagtt gcttaagaaa tacaatctgc cgtttgacgt
     7261 gatgttgccg ttgattgatg aaaccgcccg taaggtgcac gaactggaac ctaagacggc
     7321 ccagaccggg ccggccatcc gttatgacga gaatgtgatc ggcaatcact tgcggatgct
     7381 tgccgatgat cctgccatgc agcggttata cgagttgctt agccgaagca ttcacgaaag
     7441 acaataattc cgaaacatta aataaaaatg agcacaatca attacgacct tacccggata
     7501 aaagcacttg ctttcgatgt cgacggagtg ctgagcgcca atgtcatccc tttgcatccg
     7561 tcgggtgaac cgatgcgtac ggtaaatgta aaagacggtt atgccatcca attggccgta
     7621 aaaaaagggc ttcgtatcgc tattattaca ggtgggcgga gcgatgtcgt gcggaaacgt
     7681 tttatagggt tgggggtatc cgatctgtac ttcggctctg cggtgaagat acacgattat
     7741 cgtggtttcc gtgacaaaca cggacttacg gacgaggaga tactctacat gggcgatgac
     7801 gttcccgata tggaagtgat gcgtgagtgc ggattgccct gctgtcccaa agatgcggtt
     7861 cccgaggtga aagcgattgc ccgttacatt tcgtatgccg atggaggata cggctgtgga
     7921 cgcgatgtgg tggagcaggt gcttaaagca caaggccaat ggttgtccga tgatgctttc
     7981 ggatggtgat ttccagtata taccttattt atttatcagt atgcttgcta acttagatcg
     8041 ttataaaatc gtattggcct ctaattctcc gcgtcggaaa gaactgatga cgggcttggg
     8101 tgtcgattat gtagtaaaaa ctttgccgga tgtggacgaa tcttatcccg atacgttgca
     8161 aggtgaagag attcctcttt tcatagcccg tgagaaggca gccgcctatc agtcgatgat
     8221 cggaccggaa gagcttttga tcacagccga taccattgtc tggcatgaag gcaaagcgct
     8281 cggtaaacct gtcggaaggc aggatgccat agagatgttg cggagcctct ccggtaaatc
     8341 gcaccaagtg attaccggtg tgtgtctcac tacccgagaa tggcaaaaat gtttcgctgc
     8401 cgtgacggat gtccgttttg cgattcttga tgaagatgaa atcgcttatt atgtcgatca
     8461 ctatcagccc atggacaaag ccggttcgta tggtgtgcag gagtggatcg gttttgtcgg
     8521 agtagaatcc atatccggca gctacttcaa tgtaatggga cttcccattc agaaattata
     8581 cagggaattg aaacaactat agagagtgtg ccgaaactcg tatatacaac ggagtagcac
     8641 agagtctcac agagtagatt tattctctaa agaactttta taaaaaactc tgtgttgcct
     8701 tgtggtgaat tatgccttcc ttgtaggtcg catgattccg tatggcggct ccctccgtgg
     8761 aaggagaaga gtgccatgcg aaattatagt ttgatcattt gttttctgta ttttctttct
     8821 ccatttcgat attgataatt gtgttatccc atttattcat cttttgcgta cccaaatcta
     8881 ccagaaagcc cggccaaaat agaatgttcc acaggcaggc attgttaaat gtagattcca
     8941 ggacaaaagg agtcgtttgg tacccttcct ttttggctac tagttgtttg tcttcccttt
     9001 tctttttgat ttgtacagtg acactattgt cttctttgat ttccgctatt ttctgtttgg
     9061 tcgatgcttc gtagatttta gttccattca ttcccgtaaa ggtgatatct tgtttggaac
     9121 tgctgaataa tgtacagcat gatgaaaatg aaatacagac ggatagcaat aataaaatct
     9181 ttttcataat ctaagttttt aatgtgatat aattgttttc tttgatataa ttatttcttt
     9241 cggatcgagg atgctcttct tctgtgtgtg ctactgttat gggaggaact tttattgcct
     9301 gtggcaggtg tcttgatcct gataaatggc tttcagtaag cgtgctccca gcagcggacg
     9361 ataatgaccg ggttcgtaat aatgatgtat gtcggctgtg tattcgttga ttcccgtgaa
     9421 atcccagaca gcggaattac ccagtatagc cttcaatatt tttatgtctt cccggctggc
     9481 ttttttctga tagtaatccg gaccgatgac gaacttcagg ttcgtgtggt gcttatcaca
     9541 gatttttttt atggagcgaa gtacctgaat ctggctggca aatataacag gaagttcttc
     9601 catacccgca ttcgttcgct tcttgaattc tttttcatga cggctccagt atatttcgcc
     9661 atcttgcgcg atctcttttt ctctgggatt gataaaattg ttcgtgtaag gctccctgac
     9721 gggatctccc ggatttataa cccctttcat ataaggagca tacttatgtc ggattagata
     9781 atctatgtaa ggaatcattc tgtccggata aaggaactcc tgcaggaatc tcaactggaa
     9841 tcccaattgg ctgatgccgg ctgcttcggc cgaaaacaga tgattgttgc ccgataaagg
     9901 agcgtttttg tccagtgatt ttttatccaa aacgatcagt atatttttca ggggtgcacc
     9961 tacagagtcg agcagctgaa gcttttgacg gacgccgccc aggctttctc cgttgtcata
    10021 gaagcgtacg gcatggtcgt tcttatccag gtatttttcc cattctcctg tcaggaatgc
    10081 catggtacag gagttgccga gtataaagga gttataggct atcgaatcgc gattctgcag
    10141 ataattctgc catcccacat gggcttcgtt gagtagcatg ggagagtcgt cgaatcgttt
    10201 gtaggggtgt aataccctat aaggatcaaa cataaaatag acaaccacta tcgggatcag
    10261 cggcaggatc agtaaaagca acttcaggca aaaacgtgtc ttgggggaga ttctcgatga
    10321 atgatgtagc atgcgcgtaa agggtttcgg ttaaaattgt aaatagatga aagtttccgt
    10381 gtcaaatttg cctaacatca gcagagcgaa taccaacaga tagtagacac tccaccgtaa
    10441 ccatgcgggt tggcgttcaa gtgtttccat caggttgtac ttagatgcat aatattcgta
    10501 gatcaatact agtaataggg ccgaacctgc tacgatgcaa ttatgatcgc gtatgccgat
    10561 gttcatttct ttccaggaag aatgtacctc gaacgagatg ttccgtaaga aataccaggc
    10621 atcgctcagc gattgtacac gaaagaatat aagcgagagt gcgaacaata gataagtccg
    10681 gacaatcagc aagctgtcgg ccgcatattt tcctatatat tggggcagat tatagcagaa
    10741 agcagctgtt ttcatttccc agcagataag gacaccctga atcaggccgt atatggcgaa
    10801 agtcaatccg gccccatgcc acaaacccaa tgcgagaaag gtgatgagga ggctgaagta
    10861 gattccccac tgtccccagt tacgggtacc ggcggttagc ggtacataga gataatcgcg
    10921 tacccagaag gagagtgaca tgtgccaacg gcgccagaag tcggcagtcg agcgtgctgc
    10981 aaacgggcgg ttgaagttag gagacaactt gatgccgaac atataggccc ctccgatagc
    11041 aatatccgta taacccgaaa aatcggcata cagttcgata gggtagagta ggcaagtcat
    11101 tagcagttgt acacccgaga ggtcatgaat cgaatgaaac atgacatctg tttgtgggga
    11161 gatctgattg gctatcagca gtttcttgat cagtccgagt aaaatatatt tcagtccggt
    11221 caccgcgttt gagtagatga acgggcgggg atctttcaat tgtggcaaca ggtctccacc
    11281 ccgttcgata gggccggaga gaaacttcat gaagaaaagc atatagatca ggaaatccac
    11341 ccagtttctt tcgctgcgtt gctcttgcca gtacacgtct gtcagataac tgatggcttg
    11401 aaatgtgtaa aatgacatcc caagtggaaa gatgatatca tctatgaccg tgccatgaag
    11461 aaggagccat ccgccgatca gggcgatgat tcctgcgata tagacgggtt tggtcttttt
    11521 tccggctttt gccctgcttt ccatccattg tgcccaaaag aaggtgaaca gtgctaccac
    11581 tactgccgtc aacaggaaag gcagatagta ccatccgatg aaaatacaac tggttaccag
    11641 tagtataagg ttgcgggcac ggcctttgac tgcatagtag aggaagaaac agagggtaaa
    11701 cagggccagg aaactaaaag agaggaactg catcgtttat tccattttgg ttaataaggc
    11761 actgcacaaa tcgccgacat tcttgaactt aatgacctcc ctgaaattga aacgtactcc
    11821 gaaatgtttc tcgatttgag ctataatttg catgtgggtc agcgagtccc agccatctac
    11881 atcttttgag gtagatgatt cgtcgataca tacgttgtcc ttttttaaaa tatcacggaa
    11941 aatgctttgt agttgtttta atacttcttc tcgattcata tttattattg tttttagagt
    12001 ttcttctctt ttatcagttc ggcaatcttt ttacggtctg ttttattact attggtcacc
    12061 ggaaattggg aaatacaatg aatctgcttc ggcagcatgt atttgggcag cttttctttc
    12121 agatattcta tcaatgcgct ttgggtacat tcagttgtct cgacggccag atgtaattcg
    12181 ttacagattc cgtcgcagag caacggaacg gcagccacgc tgcagggagt cttgaaaaac
    12241 gactgcgcag tatattctat ttcactcagt tctatcctga aaccctgtat tttcacctga
    12301 tagtctttac gtccgcaata aataatatcc ccgtcgctat ccagaataca caagtctccg
    12361 gtccggtaat agatttgtcc gtcgggacgg tgtatcagaa ccaatgtcga tttttccggg
    12421 tcgtccagat aacctttcat tacctgccgg ccggataccc aaagttctcc cgtctctcct
    12481 tgaggtagct cgtttccttc ttcgtcggca atgatggcgc ggatgccggg aaatggtttt
    12541 ccgatagcca ccattccgtt gtaatgcttg catttgtccg aagccggaat acggtaacag
    12601 gtgcagtaaa tcgtagcttc ggtcggtccg tataggttga tgaacgttgc gttgggtgcc
    12661 gattttctga atcgctccaa cagctcggtt tgcgatgctt ctgccgatac tcccagatat
    12721 ttcagagagg gcagattgat ttcatcgaag tagggtgaaa ggagttgtag cagtgaggga
    12781 gtgacagtgg caaaggtcag ttcatacttc tccagaagtt caaacacctt gaagtgcttt
    12841 acatcctgat ggcctaccgt ataaacggca gcacctaaag taagaggata cagtaaggat
    12901 acaacggata catcgaatgt aagttcgaac atttgcaaca tgcgatcatg ttcatccaga
    12961 ttccagtcga gcgaactgta tgcccggtaa aaggcgttca agttagcccg tgtgatgggc
    13021 actcctttgg gctcgcctgt gcttcccgat gtaaaaatga tataagcgtt cctttcttcg
    13081 tccgatgaat gggactgctg ttctgacagt gcttttcccg gtagccggtc cgtatcgatg
    13141 attctgaagt gtccggtgcc gaatgctgac cggtcagtgt cacttgtaca gagcaaagta
    13201 cgcagtccgg ccagagcggc tattttgaga ttacgctctt tcgggtaggc aggatgcagg
    13261 ataacatagg tctttccacc ggccagtact gccagaatag ccgcataggt ttcaatccgg
    13321 ttttccgcta cgattccgat tctttcatct tttatttctg atagcgaatg ggtgatagaa
    13381 gctgttattt caccgagttg ggcgtaagta taatgtttat cgtcaataat gaatgcttca
    13441 ttttcgggat aacattgcat ggcggaaaga atatcattga taatatcctt ctggggagat
    13501 gttgtcatat ccattagttt ttattcatgt tttgggttta ggggttcttt atatatcttc
    13561 ttgagatcgt ttattaagat gacagtgaaa tggtctgatc tccctacgca caatcgatta
    13621 aagaatgtta attgtgtggt acgcacatgc ccggtctcgc tttccctttt tcggaagggg
    13681 aaatagcgtt ggcttcatag ccgacgactt tgaatgggat agacaacacg atactttatt
    13741 gata
//
