LOCUS       c00182_gnlPro..         5210 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LKKJNABI_182.
ACCESSION   c00182_gnlPro..
VERSION     c00182_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 19:28:58
            Original ID  :: gnl|Prokka|LKKJNABI_182
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5210
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5210
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:4053]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..4053
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..5210
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..5210
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..1726
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg182_1"
                     /sec_met_domain="ILVD_EDD (E-value: 1.6e-218, bitscore:
                     714.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GMKKNQMGKPIIAIVNSFTQFVPGHVHLHEIGQLVKAEIEKLGCF
                     AAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGM
                     LMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLIDAMIKSADDSVSDQEVANIEQNACPTC
                     GCCSGMFTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENAMKYYEEGD
                     ESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDMLSRKTPC
                     LCKVAPNTQKYHIQDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQYSITSP
                     NVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDKDRANGCIRDLEHAYSKDGGLAVLKG
                     NIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEGPKGG
                     PGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIVDGD
                     IIEIDIPARTINVRLTDEELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID"
     CDS             1774..3471
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg182_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-47, bitscore:
                     148.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIAFAYDIPSKRVF
                     SREELKVAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             3490..4053
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg182_3"
                     /sec_met_domain="ALS_ss_C (E-value: 2.7e-20, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             4053..4796
                     /locus_tag="ctg182_4"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             4860..5210
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg182_5"
                     /sec_met_domain="IlvN (E-value: 8.3e-23, bitscore: 69.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGK"
ORIGIN
        1 cggcatgaag aagaatcaga tgggtaaacc cattatcgct atcgtcaatt cgtttacaca
       61 atttgttccg ggacacgtgc acctgcatga aatcgggcag ttggtgaagg cggaaattga
      121 gaagctggga tgcttcgctg cggaatttaa tacgattgct attgatgacg gtatcgctat
      181 gggacatgac ggaatgcttt actcgcttcc ttcccgtgat atcatagcgg acagcgtaga
      241 atatatggtc aatgcgcaca aggcggatgc aatggtatgt atcagcaact gcgataagat
      301 taccccaggg atgctgatgg ctgccatgcg cctgaatatc cctaccgtat ttgtatccgg
      361 cggaccgatg gaagccggag agtggaacgg tcagcatctg gacttgatcg atgccatgat
      421 taaatcggcg gacgacagtg taagcgatca ggaagtagcg aatatcgaac agaatgcctg
      481 tcctacctgc ggatgttgtt ccggaatgtt tacggcaaac tcgatgaact gtctgaatga
      541 agctatcggc ttggctcttc cgggaaacgg cacaatcgtg gctacgcacg aaaatcgtac
      601 gaaactgttt gaagatgctg ccaaactgat tgtggaaaat gcaatgaaat attatgaaga
      661 aggtgacgaa agtgtacttc cccgcagcat agctacccgt caggcattcc tcaatgccat
      721 gacgctggat attgcgatgg gcggttctac caatacggtg cttcacctgt tggccgtggc
      781 acatgaggca ggagtcgatt tcaagatgga cgacatcgat atgctgtcac gcaagacacc
      841 ctgcctgtgt aaagtcgctc cgaatactca aaaatatcat attcaggacg ttaaccgtgc
      901 gggtggcatc attgctatcc tggcagagtt ggcaaaaggc ggtctgattg atacttccgt
      961 tctccgtgtg gatggcatgt cgctggcgga agcgatcgat caatattcaa ttaccagccc
     1021 gaacgtaaca gaaaaagcaa tgagcaaata ttcaagtgcg gcaggaaaca gattcaatct
     1081 cgtacttggt tctcagggag cttattatca ggaattagat aaagatcgcg cgaacggatg
     1141 tatccgtgat ctggagcacg cctatagcaa ggacggaggc ctggcggtac tgaaaggaaa
     1201 tatcgctcag gacggttgcg tagtaaaaac ggcgggtgta gacgaaagca tctggaagtt
     1261 taccggacct gccaaagtat tcgactcaca agaagcagcc tgtgaaggca tcctcggagg
     1321 ccgagtcgtc agcggcgacg ttgtcgtcat cacgcacgaa ggtccgaagg gcggtcccgg
     1381 tatgcaggaa atgctttacc cgacttctta tatcaaatcc cgtcacctcg gcaaagaatg
     1441 tgccttgatt accgacggac gtttcagtgg tggaacttcc ggattgagta tcggacacgt
     1501 ttctcccgaa gccgctgccg gaggtaatat aggaaaaata gtagatggag atatcatcga
     1561 aatcgacatt cccgcccgaa cgattaacgt gcgactaaca gatgaagaac tggctgcccg
     1621 cccgatgact cccgtcaccc gtgaccgtta cgtgccgaag agcctgaaag catacgccag
     1681 catggtaagc tctgccgata agggagcagt gagattaata gactgatcca cttcattatc
     1741 cattatgaat catccattat ccattaaaga actatgagta aggacttaat aacaggcgca
     1801 gaggcaatga tgcgctctct ggaacatcag ggagtgacta ccattttcgg ttatcccggc
     1861 ggttccatca tgcctacgtt cgatgccctg tacgaccatc aaaatacatt gaaccatatc
     1921 ttggttcgcc atgaacaggg agctgcccat gcggcacaag gctacgcccg tgtatcgggt
     1981 aaagtcggtg tttgcttggt gacaagcggc cccggagcaa ccaatacgat cacaggtatt
     2041 gcagatgcaa tgatagacag tacgcctatc gttgtcattg caggacaggt gggaacaggc
     2101 tttcttggaa cagacgcttt tcaggaagtc gatctcgtag gtatcactca gccaatcgct
     2161 aaatggagct atcagattcg ccgtgccgaa gacgtagcct gggcgatagc acgtgctttc
     2221 tacattgcca gtagtggtcg tcccggtccg gtggtactgg actttgccaa gaatgcgcag
     2281 gttgaaaaaa cgaaatacga gccgacaaag caggagttta tccgcagcta tgttccggtt
     2341 cccgatacag acgaagaatc ggtaaaggct gccgccgaac tgatcaataa cgccgaacgc
     2401 ccgcttgtct tggtaggaca gggagtggaa ctgggaagcg ctcaggaaga actgcgtatc
     2461 tttatcgaaa aggcggatat gcccgcaggt tgtaccttgc tcggactttc cgcattgcct
     2521 accgatcatc cgttgaataa aggaatgctg ggtatgcacg gaaatctggg accgaatatc
     2581 aatactaaca aatgtgatgt actgattgct gtcggtatgc gtttcgacga ccgtgtgacc
     2641 ggtaatctgg ctacttacgc caaacaagcg aaagtgatcc attttgatat tgatccggcg
     2701 gaagtaaata agaatgtaaa ggtagacatt gccgttttgg gcgactgcaa aaaaacgctg
     2761 gctgctgtga ccggactgtt gaaaaagaac cggcacaccg agtgggtcga tagtttcaag
     2821 gaatatgaag cggtagagga agaaaaagtc attcgtcctg aacttcatcc tgcaacggat
     2881 tcactgagta tgggcgaagt ggtgcgtgcg gtaagcgaag cgacccgtca cgaagccata
     2941 ttggtgacag atgtaggtca gaatcagatg atctctgccc gctactttaa atataccagg
     3001 gaacgtagta tcgttacttc gggtggactc ggcacgatgg gttttggcct tccggcagct
     3061 atcggagcta ctttcggccg tcccgaccgc actgtatgtg tatttatggg tgacggcgga
     3121 ctgcaaatga acattcagga gctgggtacg atcatggaac agaaagctcc ggtgaagatt
     3181 atctgcctga acaacaatta tctcggcaac gtgcgccaat ggcaggctat gttctttaat
     3241 cgccgttatt catttactcc gatgctgaat ccggattaca tgaaaatcgc tttcgcctac
     3301 gatattcctt ccaaacgtgt cttttcacgg gaagaattga aagtggctat cgacgaaatg
     3361 ctctcgacag acgggccgtt cctgctcgaa gcctgtgtgg tagaagaagg caatgtcctc
     3421 ccgatgaccc ctccgggcgg ttcagtcaat cagatgttgc tggaatgtta atccttaatt
     3481 tagaaagtta tgagtgataa gacattatat acgattatag ttcattctga aaatatagcc
     3541 ggattgctaa atcaggtgac cgctgtattt acccgtcggc aaataaacat cgagagtttg
     3601 aacgtttctg cttcttccat taaaggagta cataaatata cgattacagc gtggactgat
     3661 aaggacacta tcgaaaaggt ggtgaagcag atcgaaaaga agattgatgt gattcaggcg
     3721 cactatttta ctgaagacga gatttatttc catgagatag ccttatataa ggtatctact
     3781 cctgcttttc aggagactcc ggaagcatct aaagtgatcc gcagatataa tgcccgcatt
     3841 gtagaggtga atccggtatt ctctatcgtc gagaagaacg gcatgagtga agagattact
     3901 tccctttacg aagaacttcg ggctttgaaa tgtgtgctgc aatttgtccg ttcgggccgt
     3961 gtggctatta ctaccagctg tttcgaacgt gtgaatgagt tcctggacgg acaggaagcg
     4021 aagtataagc aaagtaaaaa ggaacaggag taatgagtga agaaaataaa atagggactt
     4081 atcagtttgt ggcagagccg tttcacgtag attttaacgg ccgcctgacc atgggcgtgc
     4141 tggggaatca tctgctgaat tgcgcaggtt ttcatgccag cgaccgtgga tttggtattg
     4201 ctacgctgaa cgaggacaat tacacatggg tgctttcccg tctggcgatc gagctggacg
     4261 agatgcctta ccaatacgag aagttctcgg ttcagacatg ggtggagaat gtctatcgtc
     4321 tctttaccga ccgtaacttt gccgtcattg acaaggatgg aaagaagatc ggctatgccc
     4381 gttccgtatg ggcgatgatc aatctgaata cccgtaagcc tgccgatctg ttggcattgc
     4441 atggaggaag catcgtcgat tatatatgcg atgaaccctg cccgatagaa aagccttcgc
     4501 gtatcaaggt gacaagcaat cagcctgttg cgacgctgac ggcaaaatac agtgatatcg
     4561 atattaacgg acacgtaaac agtattcgtt atatcgagca catacttgac ttgtttccga
     4621 tagaactgta tcagacgaaa cgtatccgcc ggtttgaaat ggcgtatgtg gctgaaagtt
     4681 atttcggaga tgaactctct ttcttctgtg atgaggtgag tgaaaacgag tttcatgtag
     4741 aggtgaagaa aaacggcagc gaggtagtat gccgttccaa agtgatattt gaataatata
     4801 gagtataaaa tcaattaata acagatggcg caagtcatca aaacaaaaaa acaaaaaaaa
     4861 tggcacagtt gaattttggc ggaactgtag aaaatgtagt tatccgtgat gaatttccat
     4921 tggaaaaagc tcgtgaagta ttgaaaaatg aaacaatcgc tgtaatcggt tatggcgtac
     4981 aaggtcccgg acaggctctg aaccttcgtg ataacggttt caatgtaatc gttggtcaac
     5041 gccagggaaa gacatatgac aaagcggttg ctgacggatg ggttccgggt gaaactttgt
     5101 tcggtattga agaagcttgc gaaaaaggta cgatcattat gtgcctgttg tctgatgcag
     5161 cagtaatgtc tgtatggcct actatcaagc cttatctgac tgcaggaaaa
//
