LOCUS       c00071_gnlPro..        15687 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EHLLENFJ_71.
ACCESSION   c00071_gnlPro..
VERSION     c00071_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:56:54
            Original ID  :: gnl|Prokka|EHLLENFJ_71
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15687
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15687
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1125:5687]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1126..5687
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15687
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15687
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(49..912)
                     /locus_tag="ctg71_1"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIITNDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQIDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLL"
     CDS             complement(1126..2286)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_2"
                     /sec_met_domain="OAD_beta (E-value: 3.9e-153, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATGGHIAMIIIGLGFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(2288..2722)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.4e-21, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKAT
                     PKPAVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             complement(2747..3718)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_4"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-14, bitscore:
                     46.1, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVIFRCNPTFHIKTRTIMNKTKIGIFLSLLLLIGLTSCGEQKSNN
                     KLLLNEVLIDNQNNFQDDYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPK
                     GDILTLVKPRQHALFWADGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGT
                     LGPNQSYARISDGAADWEVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSIS
                     AMSVVFCGLILLFIAFKVVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMA
                     LHEMQDEVHDVEETVLTITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             complement(3699..5252)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_5"
                     /sec_met_domain="CT_Btheta (E-value: 3e-290, bitscore:
                     953.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(5283..5687)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_6"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.9e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(5861..6637)
                     /locus_tag="ctg71_7"
                     /transl_table=11
                     /translation="VVYGAGEFLDTSLPASKEKEEEIFGEMLEHLTQEASRTCILIEFR
                     NLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRIRQIRKGLKNGAKVVE
                     AHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQAKIFIVKYKEKIIGG
                     SVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGFRHMEFMDVGLPFRKH
                     GYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             7162..10302
                     /locus_tag="ctg71_8"
                     /transl_table=11
                     /translation="MILGLTLLCAPSAISVYAENGVNDITVQAVMQTKTVKGTVLDENG
                     EPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYIGYKEQAIIVSGNAPLNIK
                     MVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPGVNPMDALQGKIAGLDITN
                     SSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGMPGDIATLNPNDIESIEVL
                     KDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTTLGAKVPKMRTGDSYINYI
                     KDSYKPVGTTNEEEIFGERYDAIKNNQWVNWGDEVLHSGLKQNYSISVAGGTEKTKAYF
                     SLNYTDEKSMYENDDYKVYSTRVRIDQEINKWMNAGINVQASFSNKNSRNAVLERALFA
                     TPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTKAGRAYVDAYLEWKPVKGL
                     SVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKTGYNYKWENIVTYHNTFNK
                     DHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNADNKKLNSKYLMSKGMGFIG
                     RVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWRISDEAFMAGTKSWLDNLK
                     LRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFTEYITNRNLTWEKTHDLNI
                     GIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTGSTTYKMNKNAAETENRGI
                     ELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFNAKKGDMVFKVGEGVGSFY
                     RYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYYYMNPEGERVDITAENPYG
                     VRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWGQMMNYGSVIGKYSPNPDY
                     NVPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYYVDGSFFKLKNVTLGYTLP
                     SKFTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSINFPLSRDCIFGLNLTF"
     CDS             10314..12269
                     /locus_tag="ctg71_9"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDETEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLAAKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTEGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYVFDEYARELCGECGRWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             12455..12997
                     /locus_tag="ctg71_10"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             13219..13932
                     /locus_tag="ctg71_11"
                     /transl_table=11
                     /translation="VLFDFCLTAGFTIRFDVIVLCNSFFHNEYISQCKDTISFLITIGL
                     RYLCIHKSNENGNNMENFSELIKNRRSMRKFTDEELTQDEVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEKLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             13935..14270
                     /locus_tag="ctg71_12"
                     /transl_table=11
                     /translation="MGAVKANNNKDTYKATAVTFIVIGTLFLINKLLPFASIGLPWVMN
                     KDNLLLYASICFLIFKRDKSVGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLALLIIGII
                     LFWVSKR"
     CDS             14278..15072
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg71_13"
                     /sec_met_domain="F420_oxidored (E-value: 1.3e-13, bitscore:
                     42.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPVVFLGAGNLATNLAKALYRKGFRIMQVYSRTEESAR
                     TLANEVEAEYITDLKDVSNEARLYIISLKDAAFVELLPQITDGKQHALLVHTAGSIPMN
                     IWEGHAERYGVFYPMQTFSKQREVDFREVPFFIEAKRPEDAELLKAVAGTLSDKVYEAD
                     SEQRRSLHLAAVFTCNFTNHMYALAAELLEKYHLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNKHLSMLADSQALQEIYKLMSKSIHEHHQL"
     CDS             15053..15574
                     /locus_tag="ctg71_14"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFAALGVKDLYMGSAVKIHDYRDFRDKYGLSDDE
                     ILYMGDDVPDIEVMCECGLPCCPKDAVPEVKSVAKYISYVDGGRGCGRDVVEQVLKAHG
                     KWMAEDAFGW"
ORIGIN
        1 agttctgctg tctgatacaa gaggataaat tgaattgata gaactcacct aaagcaggtt
       61 tacgttttca ggatcatgtt ttcgggcggc ttccagaaag tcatgtgctt cgtaatattt
      121 ctcttccgca taatagctga tacccagata ataacaggta tgaaaagaac tgtcgccctg
      181 gctcaccagg tattcataac gctggatagc ggtaggataa tccttattca gacaatatgc
      241 cagtgcattc tgacggttga cagcgatatt ggtggtatca atctgccgat atttctccgt
      301 ggcttcaatt gcttcgttga aataagaacc ggctatgttc agtgcggcga gcttggcggc
      361 ggcaagatag tcgtcggggt atttctcctg tatattatag tagcaccccg tggcggggag
      421 aagctctccc ataccttcga aactttgggc ctgcagatgc aaggcgatgg cggaactgtc
      481 tttctctgtc atcagactac tttctcctaa agcatcctga aacttctgta aagagagcag
      541 tagtccgatg tattgaatac gcacatattt gttttccgga ttcagatcaa gtgcctgttc
      601 ataatatttc agtgcctgtt ggtatttggc caatgaacgg cagcattcgg ctgcttcgat
      661 atatgcacgg gtattggcag tgtcattggt tatgatttcc tgataagtgg aaagtgcttc
      721 tgtattcatc ccaagtcccc gttgtgcttt acctttttgc aagagtaggg gaattgtcgg
      781 cttttctttg gcaatgagag tgagagctgc ctcgtaatcg tagtttgcta ttgcttcctg
      841 aacatgattg atgcgctgcg ccatcaccag ggtggtggta caaaggaagg cgaggagaat
      901 aatccgtttc ataaatattt attttagtgt gtcgtaacaa agacgcaaga tgctaaaaaa
      961 tatcgtattt acgaattatt cgtagccttt ttggaataga ttaacggaat gataagagaa
     1021 gataacataa tgataagtgc ggatattgca tctaaaacag caatatccgc acctaatatt
     1081 ttgtcccggc attccgaatg gaaacctgac aggggcacct tgtccctaca ttaagaatcc
     1141 taacaggata ccggcagcaa cagccgaacc aattacacct gctacgttcg gacccatagc
     1201 gtgcatcagc aagtagttgg ttggatcata ttccagaccg acaacttgtg agatacgtgc
     1261 agagtcggga acggcagata cacctgcatt accgatcaac ggattgatct tattgccctt
     1321 cttgaggaag aggttgaaga tcttaacgaa gatcacacct gatgcggtag caataataaa
     1381 tgacagtgca ccgagggcga agatcttgat ggagtcgagt gtcaggaact cagaagcctg
     1441 agtagaggca cctactgtca aacctaacag gatagtgata acgtcaatca gcggaccgct
     1501 ggctgtgtta gccagacgac gggttacacc actttctttc aacaggttac cgaagaacag
     1561 catacccagc agaggcagac cggaaggaac caggaagcag gtcagcaaca gaccgataat
     1621 cgggaaaatc actttctctg tatgagaaac ggcacgtggc ggtttcatac ggataacgcg
     1681 ttcgtgcttg gtggtgagca gacgcatgat aggcggctgt atcaccggaa ctaacgccat
     1741 ataagagtag gcggataccg caatggctcc cattaagtta ggtgccagct tggacgaaag
     1801 gaagatagcc gtcggaccat ctgctccacc gatgataccg atagcaccgg cctgcatcgg
     1861 gtcaaatccc atttccaatg caatcatgta tgcaccgaag ataccaaact gggcggccgc
     1921 accgatcagc atcagcttcg gattggagat cagtgccgag aagtctgtca tggcaccgat
     1981 acctaagaag atgagcggtg gataccagcc ggacgttact ccctgataca atatgttcaa
     2041 tacagaacct tcttcatata taccgacttt tagtccggcg tccatattga aaggtatatt
     2101 accgatcaga ataccgaatc cgataggaat taacaacatc ggctcgaact ctttggctac
     2161 agctaagtaa ataaagccta aaccgataat gatcatagca atatgtccac ctgtcgcgtt
     2221 ggcaaatccc gtgtaggtcc agaaatcggc aaggttattt cctaaaaagt taataaaatc
     2281 tcccatatta ttcaataatt acgaggtcat taccttcaag aacagaatct cccttgttga
     2341 cattgatggc agtcacttta ccgtctttgt ctgcattgat attgttttcc atcttcatgg
     2401 cttccaatat aatgatagtc tgtcctctct tcactgtatc acctacattt actttgatgt
     2461 caaggataac gcctggcagc ggggacttaa cgcccgattt gccggtagaa ggagcagccg
     2521 gttttactac cggtgtggta ggagcagccg gtgagttagg catagggcgt actactgccg
     2581 gtttgggagt agctttcggt tgtttctcca tttctacttt gtaatgcgta ccgttcactt
     2641 ctacatgagc gatattatct tcaatatctc cgatggttac tttgtatgag ttaccgttga
     2701 ttttatattt atattctttc atcgttttat ctttttaggg aatgatttac tttctgttag
     2761 gattttcacg caaggtgtaa atcttcgaac tccacggtga ataactgcgc ttcacacgag
     2821 tgatggtcag caccgtttct tctacgtcgt gtacctcatc ctgcatttcg tgtaatgcca
     2881 ttgaaatagc agcataaact tcacccggag cctgtgaaag ctctttcgct tcgactttat
     2941 cgatgccttt agccttcatc gcattgcgtt tgctcaggtt gacagcaact ttacctacca
     3001 ccttgaaggc aatgaagaga agaatcaatc cgcagaatac tacgctcatg gctgaaatag
     3061 acataccgat accgactgag tcatgttctt cgaacttttc catcttggca ttactgtcaa
     3121 gggttttgtt gttcgtgctc ggggttacgt atttgtcttt gcttccgcct tttacttccc
     3181 agtctgctgc tccgtcgctt atgcgtgcat aagactggtt gggacctaaa gttcctgctg
     3241 gtatgacaac ttgatcaagt agctttctgc ctgaatcaaa aagaccgacc caattggctg
     3301 tttcagggtt cagtttgaag ctggtatgga aggtaccacg attaggttcg ccgtctgccc
     3361 aaaataacgc atgttggcgt ggctttacta atgtaagtat gtcacctttc gggataaaat
     3421 aggttactgt atcgcccggc tggctgctta ctttcaataa acaagctgct aagtctgcgc
     3481 taccgtatga tttgttgaat atttcaatcc atgcactgtg caagccgtag tcatcctgaa
     3541 agttattttg attgtctatc aggacttcat tcagcaatag cttattgttc gacttttgct
     3601 ctccgcagga agtcaatcca atcagcaaca gcagagaaag gaatattccg attttggttt
     3661 tgttcataat cgttcttgtt ttaatgtgaa aagttggatt acaacggaat attaccatgt
     3721 ttcttcgccg ggttagacag tttcttagtc tgcaactgct gcaaagcacg gatcacgcgg
     3781 aaacgtgtgt tacgcggttc gatgacatca tcgatgtaac catacttagc tgcattataa
     3841 gggttggcaa acagttttgt atattctgct tctttttcgg caaggaactg agccggattt
     3901 tcctggtctt tggcttcacg cgcgtacaat acttctactg cacctgcacc acccattaca
     3961 gcgatttcag ctgttggcca agcatagttc atgtcaccac gaagttgttt acaactcatc
     4021 acgatgtgag aaccaccgta agatttacgc aatgtgattg ttactttagg tacagtagct
     4081 tcaccgtaag catacagcag tttggcacca tgaaggataa cgccattgta ttcctggcct
     4141 gttcccggaa ggaatcccgg tacgtctacc aacgacacga tagggatatt gaaagcatcg
     4201 cagaaacgaa cgaaacgtgc gcctttgcga gatgcgttgc tgtcgagtac accggcaagg
     4261 aatttaggct gattggctac aatacctaca gactgaccgt tgaaacgggc aaaaccgata
     4321 atgatattct tggcatagtc tttctggatt tccaggaatt caccgttgtc cacgatagcg
     4381 ctgataacct cgtacatatc atacggtttg ttggggctgt cggggataat atcgttcagt
     4441 gaatcttcca gacggtcgat cggatctgtg caatccacat atggagcttc ttcgaggttg
     4501 ttttgaggaa tatagctcag aagtgtgcgg atcaatgcca gaccttcttc ttctgttttg
     4561 gcagtgaaat gagtaacacc cgatttggta gagtgaacgc ttgctccgcc gaggttttcc
     4621 tggcttacgt cttcaccggt tacagttttc actactttcg gacctgtaag gaacatataa
     4681 gaagtacctt ccatcatcag tgtgaagtct gtcagtgccg gagaataaac agcaccgccg
     4741 gcacaaggac cgaagatacc ggaaatctgc ggaatgacac ccgaagcgag gatattgcgc
     4801 tggaagattt ctgcgtaacc tgccaaagcg ttaatacctt cctggatacg tgcaccgccc
     4861 gagtcattga taccgataca aggagcaccc atcttcattg cctgatccat aatcttacag
     4921 atcttcagtg acattgtttc cgacagtgaa cctgcagtaa cggtaaagtc ctgtgcaaaa
     4981 agatatacga gacgaccttc gatagtaccg caaccggtta ctacaccatc acccggatag
     5041 tgctttttct ccatgccgaa gttcgtgcat ctgtgctcaa cgaacatgtc catttcttcg
     5101 aagctacctt cgtcaagcag catagccaga cgctcgcgtg ctgtgtattt ccctttttcg
     5161 tgttgcttcg caattgcttt ttcaccgcct ccgatacgtg ctacggcacg gcgttcaata
     5221 agctctttaa ttttttcaag ttgattactc atgagttctt gttgtttttt tagagtttat
     5281 gattagtgtt cgcagagttc tgtcagcaca cccagtgttg atttcgggtg aaggaaagcg
     5341 atgttcagac cttcggcacc tttgcgggga gccttgtcaa tcagacggat ttctttgctt
     5401 tctgcttctg ccaaagcatt agctacgcca tcttctacgg caaatgctac gtgatgaaca
     5461 cctgcacctt tgttttcaat aaatttagca atggtgcttt cggggcaagt cggctccaac
     5521 aattcgattt ttgtttcacc tacctttaaa aaagcggttc ttactttttg atcttctact
     5581 gtttcgatgt tgtaacattt cagacccaat acgttttcgt agtaaggaag ggcttcttcg
     5641 atgcttttta cagcaatgcc cagatgctca atgtgtgaaa tcttcataac tatatttttt
     5701 tatatggttt aattatgtgc ttatatggca taaaacagca caaagaaaga catttcttgt
     5761 ctaataaaga aatatttctg catttaatta ttggggaata aagcataaaa aatgctccgg
     5821 atgggtgaca aagacgggtt ttgtaatctt gagattacat ttagacataa aacttgacca
     5881 gaagattatt cagccatggc cagctgatac ggaaccaacg gcgggtactg ctttgtttgc
     5941 ctccgaaacg gagtacgaaa tcacgataac catgtttgcg gaagggaagt cctacatcca
     6001 tgaactccat gtgacggaat ccccgttcat gggcatcttc aagtgctttc catactgcca
     6061 gtatgccggg tgactgcagt gcatacgtct ttcgcattcc tcctgaaaac cagataaaag
     6121 cattttcgcc ggaatagatg cagacggagc cgccgataat cttttccttg tattttacga
     6181 tgaatatttt tgcctgtttt cctctgataa gcatgctgtt catgtggcgg aaaaagtcat
     6241 tggcagggaa atatctccgt attcgtgaag aataaacttt gtgcagcatc cgcgagaatt
     6301 ccttaatctc ttccaccgta tgggcttcta ctactttggc tccgtttttg agtcctttcc
     6361 ggatctgacg gatacgtgac gggctgaaac ggtcttccgc tttctgcgta ctatgcagag
     6421 agttacggac acgcagccag ttgaccggaa aaaagtcgtt ctttcggaag aaacggtaac
     6481 cgaacatgga attatccaga ttgcggaatt caataagaat gcaggtgcgt gatgcttctt
     6541 gtgtgagatg ctccagcatt tcaccgaaaa tttcttcctc cttctcttta cttgccggta
     6601 gagaagtgtc cagaaattca cctgcaccat ataccacaca ttgtttgaca agagaggagg
     6661 gaagccactt tttggtcttg cgtatggcgg caagcaggcg tgctacaggt ctgccttctt
     6721 ctgttgccac tatcagtagc ggggtatatc ccggagtcga ttcatagatc tgaaacaact
     6781 ccttggaatg aaaagtattg gttcccggta aatcaggaat gtcttttccg cgataatatg
     6841 ttgttagttt aagtggcatc caaatacaaa tttacacttt ttattcttca ttcaacaata
     6901 aaaaagagaa tttgttggct tagcctaaaa tttgtctttt tatcctttgc atatatttga
     6961 ggaaaaaaag gcttgaaaaa gcgaattttt gtattattgt cgtcctttgt gagtacagaa
     7021 gtaaaatgga aacgtctatg taaaagatta tgctaattgt attttactaa acaaaggaaa
     7081 attaatatta actttaaatt aaaacgaatg agagagaatg catttgttga agcgtggaag
     7141 acacagcata gacgcgtttc catgatttta gggctgactt tattgtgtgc cccttctgcc
     7201 atatctgttt atgcagaaaa tggtgtgaat gatattactg tgcaagccgt catgcagaca
     7261 aagacagtga aaggaactgt tttagatgaa aatggagaac cgttgatcgg tgtttctatt
     7321 gtggtgaaag gtacaagtac aggtacgata actgattttg acggtaagtt ctccattaat
     7381 cttccggccg gaagtaaaga actggttgtt tcttatatcg gatataaaga acaggctatc
     7441 attgtgagcg gaaatgcccc gctgaatata aagatggttc cggatacaca ggctttggat
     7501 gaggtagtgg tcatcggtta cggtacggta aagaaacgtg atttgacagg tgcggttgct
     7561 tctgtgaaat cagaggatat caccatgaat ccgggcgtga atccgatgga tgcgctgcaa
     7621 ggtaaaattg caggtctgga tatcactaat tcttcaggtc aggcaggttc gtcaccgaca
     7681 gttcagttgc gtggtacccg ctctttgcag ttggatgagg atggtaatat ttcttccgat
     7741 gcatttaagc cgacttatat tatcgatggt atgccgggtg atattgctac cttgaatccc
     7801 aatgatattg aatctatcga agtactgaaa gatgcatctt ctacggctat ctacggttca
     7861 agtggtgcga atggtgttat tatcgtgact acgaaaggat ccaagagtgg aaaaccggtc
     7921 atcaatttca atgcttatgc cggaacgact ttaggagcta aagttcctaa gatgcgtacg
     7981 ggtgactcat acattaatta tataaaagat tcttataagc ctgtcggtac tactaatgag
     8041 gaggaaattt tcggtgaaag atacgacgcc atcaaaaaca accaatgggt aaattgggga
     8101 gatgaagtat tacactcagg tttgaagcag aattatagta tttccgttgc cggaggtact
     8161 gagaagacga aagcttattt ctcgttgaac tatactgatg agaagagtat gtatgagaat
     8221 gatgactata aagtgtactc tacccgtgtc cgtatagatc aggaaatcaa taaatggatg
     8281 aatgccggta ttaatgttca ggcatctttc tccaacaaga attcacgtaa tgccgttttg
     8341 gaaagagcat tgtttgccac cccgttaggt actccttata atgaagacgg ctctatcacg
     8401 gaatttccga ttcccggttc atcatcagat ccaaatccgt tagcagacga acaagatgga
     8461 gtatataaga ataatactaa agcaggaagg gcttatgttg acgcttatct tgaatggaaa
     8521 ccggtaaaag gattgtctgt caagtcacag cttggaggca gttattctca atctcgggcc
     8581 ggtaaattta tgggagaagg ctcctataat gtgttgaaag gcagtacggt ggcatatggc
     8641 gaagctacca ataagacggg atataattac aaatgggaaa acatagtaac ttatcacaat
     8701 acatttaata aggatcatga cctgacggtt acaggggtta cttcctggaa ttacaatcag
     8761 agtgaagaat attatgtcta tggtgaaaac ccggcgacca atgatatgtt gtggtacgca
     8821 ttgcagaatg ctgataataa gaaactgaac agcaaatatc tgatgtcgaa agggatgggc
     8881 tttatcggtc gtgtcaacta ctcatacaaa ggtaaatacc tgttctctgc ttccagtcgt
     8941 tatgaagcgg attcccgttt gtcgaaagac aatagatgga atttattccc ggcagtttct
     9001 gtaggctgga gaatctcgga tgaagcattt atggctggta caaaaagctg gttggataac
     9061 ttgaaactgc gtgtaggtta tggtgttgcc ggaactactg ccggtattgc tgaatacagt
     9121 tctatggcat ctttggaaaa tgtaacaacc tctttgggag gaatgactgt tccgtcagcc
     9181 aagtttacgg agtatatcac taaccgtaat ctgacatggg agaagactca tgacttgaat
     9241 attggtattg atgccagctt cctcaataat cgtatcgatc tgacggtgga tttgtatcgg
     9301 acaaaaacaa cggatgtaat tctttcgcag gcattgccga catctattat gggtaattac
     9361 acaggtagca ctacttataa aatgaacaag aatgctgctg aaacagaaaa tcgtggtatt
     9421 gaacttgctc ttaatacccg taatattgtg aagaaagatt ttacttggag ctcaacagtg
     9481 acatttaccg ccaacaaaga aaaaattaaa tctttgatcg aagggcagga tatgatgttc
     9541 aatgcaaaaa aaggtgacat ggtgttcaaa gtcggcgaag gagtcggttc tttctataga
     9601 tataaagtgt tgggtatctg gcagtatagc gaaaaagaaa ctgctgcttt gttcggatgc
     9661 gaaccgggcg atattaagct ggatttacct agtgtgaaga aggacggaaa tggttattat
     9721 tatatgaatc ctgaaggaga acgcgttgat attacagcag aaaatcctta tggtgtgcgt
     9781 gcggattatg accgtcaggt aataggtcgt aatactccgg actggacatt gggctttaag
     9841 aataatttca gatacaaaga ttttgatttg tctgtcttcc tttatgcacg ttgggggcaa
     9901 atgatgaact atggtagtgt gataggtaaa tattcgccta acccggatta caatgttcct
     9961 acttatttta cttactatga caagacgatc gaagcagatc aggatgtctt gttctatgct
    10021 atcgataaat ccaaggatag aagtgcttat gaaggatatg attcgatgta ttatgtggat
    10081 ggatcattct ttaaacttaa aaacgtaaca ttgggttata cgttacccag taaatttaca
    10141 aaacgttttg gtatcagtaa tctgagagtt tatgcgacaa tgaccaacct gtttacttat
    10201 tcgccaaaca aatatgtgaa gaattatgat ccggaaatga acggaagcat caacttccca
    10261 ttgtctcgtg attgcatatt tggtcttaat ttaactttct aaaaaatagc aatatgaaaa
    10321 agatatatag tttagttcta cttgttgccg gtgttttttc ttggggctct tgcagtcttg
    10381 atgaagtgaa ccccaacaac tcgggtcagt tctccgatgg ttcttataca ttggaaactt
    10441 ataaggcatt caccaactcg tgctatacag ccttgatcaa caacatctat cagagtagtg
    10501 actatctggt ttgtacggaa gcgggtactg atatttggga agaacctaaa tcgggctcca
    10561 gctatcagcg ttatcatagt tataacggta tgaaaaccga tgatagctat tattataaag
    10621 tgtggcaata ttcttatctg tgtatcaaca gctgtaatat tgtgattgac ggagctgaga
    10681 atgtgacagg ggatgagact gaaatcaatg aatgtgtggc acaggccaga tgtctgcgtg
    10741 cttactatta tatgaatttg gtggagcagt ttggaaatgt cgatttgcag ttgaaggctg
    10801 ccgatagcga gaatatttct tttgatgctc accgttctac cgttcccgaa atttatgctg
    10861 ccattatcga agacctgaag tttgccgtag agaatctgcc cgtaagtttc agtgattact
    10921 atagccgcgt tacaaagaaa tcggcgatgg gattattggc acgtgcatat attaatggtg
    10981 ccggttatga tctgaaagat accgatggtg tcagcttcct ggaaaaagcc tatgatacgg
    11041 cgacaaccat gattaataat aaagcgattt atgagtggta tatgcatccc gcttttgccg
    11101 atgtattcaa cgaaaataat aatcgtaaca atgaagaagc tctgttcata gctgcgggtg
    11161 ccgaaagaaa ttcggacgct tacaccaatg gtaactactc acaaagtgaa atgttccgtc
    11221 acttcttacc ttcgttggga acatatacgg acctgggttt ggtcgacaag acttcaaact
    11281 tcgtatacgg tcgtccgaac agtaatatct tcctgccatc caaatatctg atggactgtt
    11341 ttgctgctga tatgaacgac tctcgttttc gttattcatt tatctcagct tactcgtctt
    11401 attctatacc ggcatggggg gcgacttatg aatatggagg ttcagcgtgt gccaaagaaa
    11461 tcacaagcac acttgctgct aaatttggta ttcccgcatc taatataggt aagaaagttt
    11521 atcctcattt caatttggaa tccaatagta cagccgatgc taattactgc cagctggcta
    11581 tctggaatgc agatggaaca gcgaagacta ctcaggataa gacagagggt aatattcttc
    11641 atcctgccat gcctttagat ccggcagaag ctcatcaata tgccgtttat tgttctttga
    11701 agacgctgac agaagaggaa aaagctcaat atccgggact ggttcttaat gttttcgatc
    11761 tttacgatga gaatggaaca gccagagcta cttatgacaa gcctagtgct gccagtgctt
    11821 tgtggttatc tatttatccg gctctttcta aattcaatat gccgggtaat aagtttgtcg
    11881 gcagagacgt tcagagaaaa actgtggatg tgatgatcat gcgtatggcg gaagtttacc
    11941 tgattgctgc tgaagcatcg gtacgcttga acaagggaga tgctgccaaa tatattaatg
    12001 tactccgtac gcgtgccggt gccggtacgg tcagcgagtc gcaggtggat ctgaattatg
    12061 tttttgatga atatgcccgt gaactttgtg gcgaatgtgg ccgctggtat ttgctgaaac
    12121 gtaatgcagc ttttgagact cgtttggctg cttataataa gcgtgctgcc gagcacttta
    12181 agaaagaatt ctatttgcgt cctattccta cgaaatatct ggatgcgatc aataatccgg
    12241 cagaattcgg acaaaacgcc ggttattaat cagttattaa taatcaagca taattaatag
    12301 gagccgggca ggatatttct cttgtccggc tctttgtttc cagacctgta tcctgcgtaa
    12361 aagtttaaaa aggatttccg gtatattttc attgtatcct gatacagcct tttattattt
    12421 tctttatttt tgtgtgtcca aacaaaataa cgctatgata gaagaaatgc ttgcttataa
    12481 cagagagttc gttaagaacg agggatataa agaatatata acgaataaat atcccgataa
    12541 aaagattgct atcttatcct gtatggatac acgtctgaca gctttactcc cggccgcact
    12601 aggcattaag aacggagacg ttaaaatgat caagaatgca ggaggcgtca tttcccatcc
    12661 tttcggtagt gtgattcgca gtctgcttgt cgctatcttc gagttaggtg tggaggaaat
    12721 aatggtgatt gctcattctg actgtggagc ctgccatatg cacagtgaag aaatgcttga
    12781 gaagatgaag gcacggggta ttaatgccga ttatattcat atgatgcgtt tttgcggggt
    12841 cgattttcat tcttggctcg atggctttga agatacggag aagtcggtaa ggggaacggt
    12901 cgattttata gttcatcatc ctttgattcc gtcggacgtg aaagtgcacg ggtttatcat
    12961 agactccact actggagaac tgacgcgaat tgtataggaa atcgcccttt ctgcctatca
    13021 ggaactgcat aaaacatggt gtcactatcg caacaggata gtgtcactat cactgtctca
    13081 tggtgtcact atgtcattgg gataccgaca ctatcccaaa tgaaaaaaat aaggcagctt
    13141 tttatcggct gcctttatct ttctgcggtt atatactttc tttgactcat gcactcgttt
    13201 gtaacaaacg gggtgtccgt gctctttgat ttctgcctca cggctggctt tacgattcgc
    13261 tttgatgtaa tcgtcttgtg taattcgttt tttcataatg aatatatttc tcagtgcaaa
    13321 gatacaattt catttcttat tacgatcggt ttgcgctatc tttgcataca taaatcaaat
    13381 gaaaacggaa ataatatgga aaatttcagt gaactgataa agaatcgccg cagtatgcgc
    13441 aaatttacgg atgaggagtt aacacaggat gaggttgtgg cactgatgaa agctgcctta
    13501 atgtctccca gttccaaacg tagtaatagc tggcagtttg tggtagtcga tgataaagaa
    13561 aagttgaaag aactgtctca ctgcaaagaa caggcttctt ctttcattgc agacgctgct
    13621 ttggcgattg tcgtgatggc agatccattg gcgagcgatg tctggattga agatgcttct
    13681 attgcttcca tcatgataca gttgcaggcg gaagatttgg ggctgggaag ctgttgggta
    13741 caggttcgcg aacgtttcac tgcaaccgga atgccgtctg acgagtttgt tcatggaatt
    13801 ttggatattc ctttgcaact gcagattctt tccgtgattg ccatcggaca taagggaatg
    13861 gaacgtaagc ctttcaacga agaacacctc cagtgggaga aaattcatat taataagttc
    13921 ggaggaaaat aacgatggga gctgtcaaag caaataataa taaagatact tataaggcaa
    13981 ctgccgtcac ctttattgtc atcggaactc ttttcctgat caataaactg ctcccctttg
    14041 cttctatagg tttgccttgg gtgatgaata aggacaattt attgttgtat gcctctatct
    14101 gttttctgat attcaagcgt gacaagtcgg tcggctttgt gctgttggga ctgtggctgg
    14161 tgatgaatat cggcctggtg atgtcattgc ttggttcctt gtccggctat ctgttgccat
    14221 tggcactgtt gatcatcgga attattttat tttgggtttc aaaacgttga agaaacaatg
    14281 aaaagaagta tagaagatac gcctgttgtg tttctcggtg ccggaaatct ggcaactaat
    14341 ctggcgaaag cgctttaccg gaaaggattc cgtattatgc aggtatacag ccggacggaa
    14401 gaatcggctc gtacgttagc caatgaagtg gaagcggaat atatcactga tttaaaagac
    14461 gtatcgaatg aagcgagatt atatattatt tcattgaaag atgccgcttt cgtcgaactg
    14521 ttgcctcaga tcactgatgg aaagcagcat gcgctgctgg tacatacggc aggcagcatc
    14581 ccgatgaata tttgggaagg tcatgcggaa cgttatggag tattttatcc gatgcagacg
    14641 ttcagcaaac agcgtgaagt tgattttcgg gaagtacctt tctttattga agcaaaaaga
    14701 ccggaagatg ccgagctgct gaaagcggtt gccggtacac tctctgataa ggtgtacgaa
    14761 gccgattcgg agcaacgcag aagtcttcat ctggcagctg tctttacctg taactttacc
    14821 aaccatatgt atgctcttgc cgccgaattg ctggaaaaat atcatttgcc atttgatgtc
    14881 atgcttcccc tgattgacga aacggcacgc aaagtgcatg aactcgctcc tcgtgatgcg
    14941 cagaccggac cggctgtacg ctatgacgag aatgtgatga ataagcatct ttctatgctg
    15001 gcagacagtc aggcattgca ggaaatttat aaattaatga gtaaaagtat ccatgagcac
    15061 catcaattat gatctatccc gcatcaaagc actggctttt gatgttgacg gagtattgag
    15121 ttcgacaaca gtcccgttgc atccttccgg agaaccgatg cgtacagtga atatcaaaga
    15181 cggttatgcc attcagctgg cggtaaagaa aggactccac attgctatca ttaccggcgg
    15241 acggacagaa gcggtacgta tccgctttgc tgcattgggt gtgaaggatc tgtatatggg
    15301 ttctgcggtg aaaattcatg attaccgtga tttccgtgat aaatacggtc tgtctgatga
    15361 cgaaattctg tatatgggcg atgatgtgcc tgatatagaa gtgatgtgtg agtgcgggtt
    15421 gccttgttgt cccaaagatg cagttccgga agttaagtcg gttgcaaagt atatatctta
    15481 tgtcgatggc ggtcgtggct gtggacgtga tgtggtggaa caagtattga aagctcatgg
    15541 caagtggatg gcggaagatg ctttcggctg gtgagttgta aatcactaaa tgataaataa
    15601 aactatgctt ggaaatttag ataaatatca gattatatta gcctccaatt ctccccgccg
    15661 gaaagaactg atgtcaggct tgggagt
//
