LOCUS       gnlProkkaMBFNCBCI_8    13574 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MBFNCBCI_8.
ACCESSION   gnlProkkaMBFNCBCI_8
VERSION     gnlProkkaMBFNCBCI_8
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 15:19:43
            Original ID  :: gnl|Prokka|MBFNCBCI_8
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 10226
            Orig. end    :: 23800
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13574
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8574]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8574
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13574
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13574
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3232..4068
                     /locus_tag="ctg8_10"
                     /transl_table=11
                     /translation="MMEIKSPMELATEALSYNNQNIASEAPKLLLCSSIASVSDQGSNK
                     GVTPLAGIGKEHPELNWYYLYLPNKELKRYIGVFSGRKSVKLRKPSGEAEERYFCFKVF
                     SYTSADHRKRFEQCAYTKEEYTARRDSARVVKEAFATGSARKLNALTDEKEIEGNGWLF
                     VCAPLDQLELILSAMFPRQYLVTDYNTHCAAVIPQRQMEEFIYLYESMPYNIELMNRPL
                     EDYLQKKQRIRITGGVFRGKEGCIMRLHRNTRLVFAFGNMTVAVSYLHAFPFEKVE"
     CDS             4190..4294
                     /locus_tag="ctg8_11"
                     /transl_table=11
                     /translation="MAKQITPTPPLKGQAAIDFITEISKKRRSPSRKG"
     CDS             5001..6323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 207.8;
                     E-value: 3.3e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_12"
                     /sec_met_domain="CTP_transf_like (E-value: 1.2e-15,
                     bitscore: 49.1, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 7.8e-120, bitscore:
                     390.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 7.3e-64, bitscore:
                     206.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENSKKVYVGMSADMIHPGHLNIIREAAKLGCVTVGVLTDAAIAS
                     YKRLPYLDYNQRSEIVRSLKGVDNVVPQETLDYVPNLERLKPDFVVHGDDWMQGVQSNV
                     RNRVIECLKQWGGKVVDIAYTKGFSSSAENERLKEIGTTPEIRQKRLRRLINAKKIVRI
                     LESHNGLTGLIAENVSVIVNGVKHEFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLND
                     TLECTTKPVIFDGDTGGKIEHFVFTVRTLERLGISAVIIEDKVGLKQNSLFGTDAVQIQ
                     DTIEGFCNKIRTGKNAQVSDDFMIIARIESLIAGKSIDDALARAAAYVEAGADGIMIHS
                     KNKSGDDIKEFCQRFRVANVSTPIVVVPTTYSHITETELASWGVNVVIYANHMLRSAYP
                     SMVNCAKSILMHERSQEAVNDYCMPIKEILELIPGTKKTLK"
     CDS             6320..7459
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 53.7;
                     E-value: 2.5e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_13"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.4e-19, bitscore:
                     61.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.9e-18, bitscore:
                     55.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPDFFINSLSQRGIDFFAGVPDSLLKNICAYIADHKDGHHNII
                     AANEGAAVGLAAGHYLATGHIPVVYMQNSGEGNIINPLASLTDKDVYSIPLLLLIGWRG
                     MPGVHDEPQHVKQGKVTIPLLDVMGIKHVVMSKDEKELLKQIEDALFFMETKNEAFAFV
                     IEKDTFDSYELQSGSTSTLSMSREETIQAIASSIGQEDCIVSTTGMISRELFEHRTQMK
                     QGHEKDFLTVGSMGHASQIALGIALEKTDRRIWCFDGDGAVIMHMGSMAIIGSKQPKNY
                     IHVVFNNGAHDSVGGQPTVGLDIDLPGIARSVRYNAVHTVSDMNGLKKVLSDIRLEDGP
                     VLLEVKVRKGNRKDLGRPTTTPIQNKEAFMGFLQDKELN"
     CDS             7462..8574
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_14"
                     /sec_met_domain="Fe-ADH (E-value: 9.3e-72, bitscore: 232.8,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEYYIGPDLNTQLAALLQKLNVTKVFLVRGKKSYTSCGASDVMD
                     AVLSGRGIKTVCFFDFLTNPRVEDVRKGVLLCKSQCPNIILAVGGGSALDMAKLIRYHI
                     YKETDSYIPLVVIPTTAGTGAETTHFSVCYINGEKQSIADSAMLPDYAFVCSELTSHND
                     AYLTACTGFDAVAQAIESYWSVNSTDESRSYSLKALGLLWKQLPLLIKNLNNKELRSEV
                     AEGAYYAGRAIDITTTTAPHAFSYKFTSLYGIPHGHAVALTFPYFFALNLCGERLQSTL
                     NSYEYGQRMKLLVQFLDADRSDFLSCQLHMSTYISSLGLSAKALTFDELASAVSSFNEQ
                     RGRNNPVVIDEEVKSGLQNYFMELKESDKE"
     CDS             8611..9330
                     /locus_tag="ctg8_15"
                     /transl_table=11
                     /translation="MRIQNLYYKLGGKKGGFLQTKWSGYIQKKTVKRNRKLLQDKGICA
                     LDAMSAACKEAGVSFGMEFGTLLGAYRNQGFIPYDDDMDLTMWAEDCSRDFENVLLKYG
                     FYKKRAFYLVTVDSNGKRTRKLTEIALDYDGLQVDIFFSFRKTEITRSIFVYCPPVVNE
                     KMTAREFVLPIGLSPRLVTVRNKQYPAFADPHKTLSLIYGEDFMIPRKNASATKSIQSN
                     VIIHDMFVAYGEGFMLE"
     CDS             9358..10779
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_16"
                     /sec_met_domain="Polysacc_synt (E-value: 2.4e-37, bitscore:
                     120.0, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRTSGFVAVIWSLIERLSSQVISFLLGIVLARLLSPSDYGIVGM
                     TMIFILLSNVFIEAGFANALIRKTNRTEQDLSTAFYFNVLIGILAYCILWIGSPFIADW
                     FKEPLLSLLIRISGVNVLLNSLCIVQTALLTANLDIRRQTIINLCGQIPAGLITAILAY
                     NGLGVYALVFQTIIASCIRVIMLWLYTPWRPQEKFNRESFLSLWNFGSKLLGANLIGTA
                     FNQVSSVLIGKYIGKSDLGYYSKASNLCGNIDSVSSGVVQKVALPMLSEFQKDKVLLSE
                     KFREMMRLLIMGMAPLISFFCFTASDIIVILWTEKWIQCAFVFQILIVGAAFNPIGHMS
                     LSLMQTVGNSALILKLEVPKKIIYCIYLAIGFCYGLVGLAVAQVLINITGALINMWATK
                     RIVKYSYMRQIVDVLGYMVIAFIVGYIWFNMIHTGYMFFNILLMFMLIVFTYFAILVMI
                     KDAILIKYVRKIIGL"
     CDS             10983..12263
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_17"
                     /sec_met_domain="Wzy_C (E-value: 4.5e-09, bitscore: 27.6,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIICVFIFLIISLLLIVNFKCTFMVVSACSMVLGCMNGVGPFGM
                     YQAVSIAAFSIFMLRYFYWKDMRTYPLLFSSILLIVSYVLSNHYAVYRHYGSLVSCIVV
                     DVASLFVFYQIISKNSRYIFIYIRTCVILSLVVGVYTLVETIISSNHYMFIVNSLELYS
                     QDIIVEDIRFGMKRAQAIFGMHTTLGGFSTMMAGLLLWVRLNCTLYVKKLGKKKLSIAI
                     GLMIIAVFLTGTRSTIAGLAVVLMSFFSFKHIKMKYVFIAIVSVVIGFMALDAYLDKII
                     LSFTDTESVGGSNTDMRSIQFELAALFMMQSPFLGNGISYTFEYVADKYKEMCGAESLW
                     IPIMIDFGILGITAIIVFIIQVGYYIKKYCEIRLLFFLLGILVFNSLSSIPAFSFTQLF
                     YLFVIIAFLKKYQESICNSPSSFPSIK"
     CDS             12227..13210
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_18"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.1e-35,
                     bitscore: 111.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLSIIIPVYKVEKYIRDTLQSIYRQQYDENLFEVIVINDGTPDD
                     SMRIVAEFTNKHANLHIINQKNQGLSCARNAGLKIAQGEYVWFVDSDDTVTEESIGKVI
                     ECIERSKADVIGFSILKVSEANRVSEVESAIWNEHCRFSSNQIVCDKSILFSLHTGAAV
                     RYVYRRAFLQMNHLRFYPGILYEDQEFLPRVFSLANSFYISSFISYRYLLRSSGSIMSQ
                     FSLRSLRDTLTIVRSYETWLQEEIKGKSALINAYINGCVFNHTYWLLSFKAVTFRDEQK
                     EFMRDHYAEIRRKCLTAGWKSLKGNFRLTRAVRLLMVFLIPYHLIK"
ORIGIN
        1 gtgcccggat ttatcgtgtg caaagtactt ttcatgaggg ggaagctctg acggatgatt
       61 gggcgactag ttcatttgga tatggttcgg ccatgcagga aaatctggcg ggaattgagg
      121 attatacccg tgtgggatgt attatccaac cggagcaatt ggtaaaatat ggtgaattgt
      181 gtttgcgtga gaatgaaata gcttacgctg atcccggttt cttccgtctg tttgattttg
      241 aattgctgaa aggcgaccgc acctcttgtc tttccatgcc gggccaggtt gtgatcacgg
      301 aacggattgc ccgtaaatat ttcagagatg aagaccctgt cgggaagata cttatcttta
      361 acagtaatat gggaaaaatg tcttgtgagg taaccggagt catgaaagga atgccttcta
      421 attcgcatat acattataat tttcttttat catatgccac cttacctaaa tgggtacagg
      481 agtattggta taaacatgaa gcctatacat atgtattgct ggattcgccc gagcgcaaag
      541 aagagataga acgtgctttt cctcaattgg ccgagaagta taaaactgaa gaagcattga
      601 aaaacaagac ttggggagtg aggttggagc cattggagaa gattcatctt aatcctcaat
      661 taggttatga ggccgagttg aaagggaacc gttcggccat tatcgcattg attttcggag
      721 ctattgctat tttgattatc gcttggatca attatataaa cctgacagtt gcccgttcta
      781 tggagcgtgc aaaggaggtg ggggtgcgca gggtagtggg agctttcccg aaacagcttg
      841 tcaatcaatt ccttttcgag gcatttgtaa tgaatctgat tgcctttgtc attgctctcg
      901 ggctaatcga attattactt cctgcattca atcagttggt aggacgcacc atcactttct
      961 cggtatggtt caccgaatat tggggcattt tagtcttgct gctttttgta gccggtattt
     1021 atatctcggg ttactatccc gcgcgtgcgt tgttacgcaa aaagccgatt gtattgttga
     1081 aaggtaagtt tcagaacagt cgtgccggag agaatacacg taaaatattg gttattgtac
     1141 aatatacagc ctccatgata ttgctttgtg gtacactgat tgtttttgca caactcaatt
     1201 acatgcgtcg ccagtctttg ggggtaaaga ccgatcagat tttggtaatc aagtttcccg
     1261 ggcctaccga gggaatgaaa acaaagatgg aagccatgcg gaaagtgatc agaaagttgc
     1321 cgctggcttc aaaagtaact tgttccggag ctgtaccagg tgaagaagta gccatgtttt
     1381 tatccaatca tcgtgcgcat gatgcattga agcagaaccg gttgtacgaa atgttaagtt
     1441 gcgatcctga ctatatagat gcatacggac tggaggtggt agccggacgg ggtttttccg
     1501 aggaatatgg ggacgatgtg aataaattgg ttatcaacga aacagccgcc cgtatgttag
     1561 gatatatgga taatgatgat gctattggtg aggaaatagc tgttgaaacg gtaggagagc
     1621 ccatgcaggt aatcggagta gtgaaggact atcatcagca agcgttgaat aaaggttata
     1681 caggagtaat gctttttcat aaagataaga ttgattggat tcctcagcgt tatatctcag
     1741 tcgtgatgaa accgggtgat ccttcggaat tagtatcaca gataggagaa atatggaata
     1801 attactttgc ggattccagt tttgattatt tcttcctcga ccagttctat gaccggcagt
     1861 accgtcagga tgaggctttc ggcgtattga tgggaggttt taccggattg gctattttta
     1921 tctcttgctt aggtttatgg gtgttggtta tgttttcttg tgccgtccgc accaaggaga
     1981 tgggcattcg gaaagtattg ggggcatctc gttggaattt gttttatcag ttgggtaaag
     2041 gtttctttat tcctattatt atcgctattc tgattgcgtt gcctgtggca tggggcagca
     2101 tgaatgcatg gttggctcat tatccgttcc gaacagaatt gaaagtgtgg ttctttctgc
     2161 ttcctgtggt cttgatgttg ttgatttctt ttctgactgt agcaggacaa accataaagg
     2221 ttgtttatag taaacccgct cggtcattga aatatgaata atggaatata agatatccgt
     2281 ggttagtaat tcatttacaa ggaatatcat ttaaaaccaa tataaattat cgtaccagtt
     2341 cattatggca gatcaatact gataaacttt gaaaaccttt tgaatttttc tacaaaacta
     2401 attttgcgtc taaaattatt ttattaattt tacagcgttt ttaaggagag tctaactctc
     2461 tatagttaca aatgagcgat gagaaagggt gtcctgatgg catcctttct cttttgtagt
     2521 gtgtttttgt ataatctata ttgtatttta cttatgtcac gattatgtga aatcacgata
     2581 catcttttgt atttccgttt cttttacttt tatcagactt aatcgttttt cttgcattaa
     2641 aaaacaattg gacctccctt tgttatatat ttaacactct tttaatctca ttttgttgaa
     2701 caatctacgc gattcaaatg ttaatataat gtgtttttca tagtaataga tttaagatta
     2761 atagttagta tttgcttgtg aaagtcagta cacttacgga taaaagcgtt tatccgaaaa
     2821 gaaaagagag gcgaccggaa acggaagcct ctttcttttt gagcattttt agttcaccat
     2881 aattattgtg agaggaaaat tgattctgat tgtataaata atataatgtg ttgaaaataa
     2941 gatttttccc tttttaagcc tttaataaaa aatggagttc tcttagtaag agaaccccat
     3001 tttgctgcaa agatagctat aattccttaa tacagaaaat tccgcattaa aaaagtattc
     3061 caaagtatgc ttataaatga caattgtttg caaaaattat aactatagga cactctatca
     3121 ggcatttaag taaacttggg gttctcttac taagagaacc ccaacaaaaa aacgaaaatt
     3181 gatggcttat tcgagcctca ttttttagaa gaataattta attatgatgt tttgatggaa
     3241 ataaaaagtc ctatggagct tgcaaccgaa gcactctctt ataataatca aaacatagcg
     3301 agcgaagcgc ctaagttact gctctgcagt tcaatcgctt ccgtctcaga ccaggggtca
     3361 aataagggag tcacgccatt ggcgggaata gggaaggaac atcctgaact caattggtat
     3421 tatctgtatc tgcctaacaa agaattgaag cgctatatcg gcgtttttag tggcaggaag
     3481 tccgtaaaac ttcgtaagcc gtcaggtgaa gcagaagaaa gatacttttg tttcaaggta
     3541 ttttcctata cttcggcgga ccacaggaaa cgcttcgagc aatgcgccta tactaaggag
     3601 gaatatactg cccgtcgtga ttccgcccgg gtagtgaaag aagcctttgc caccggttcc
     3661 gcccggaaat tgaatgcttt gacggacgag aaagaaatcg aaggcaacgg ctggctgttt
     3721 gtctgcgctc ctttggatca gttggaactt attttgtctg ctatgtttcc tcgccagtat
     3781 ttggtgacgg actataacac gcactgtgcg gcggtcatcc ctcaacgtca gatggaggaa
     3841 tttatctatt tgtacgaatc catgccttac aatatcgagt tgatgaaccg tcctttggag
     3901 gattatcttc agaagaaaca acgcatccgg attaccggtg gcgttttccg agggaaggag
     3961 gggtgcatta tgcggctgca tcgaaataca aggttagtgt tcgcttttgg aaatatgacg
     4021 gtggctgtga gttatcttca cgcttttccg tttgagaagg ttgagtgaag atagtttctg
     4081 ttcttgtgct catcttttat tgaaataagc attattgagc aaaataatat ttgaatttgc
     4141 ttggatatat gatgaaaaat catgttcctt gcaaaattaa ctcatactta tggcaaaaca
     4201 gataactcct actcctccct tgaaagggca ggctgcaatt gatttcatta cggaaatcag
     4261 caaaaaaaga aggtcaccca gcagaaaagg ctaaggtgaa agagggggca tgcgcataaa
     4321 ggcgttgctg acctttaatt tctagcactc gtatgaataa agatattcgg gtaatttgct
     4381 tgtcagaaga ttatgaattt aaaccgtttg actgtggaaa tgatgatctg aatggtttct
     4441 tgttacaaga ttattggatg atgaggaaca gccgatagat aacctagggg agtgagccat
     4501 tcgaaaattt actactcaac gaaacaattc actttattac ggtagtgatg ccggtgctga
     4561 aatggctgcc acatatcatg gtgtgattgg aacggtgaag cttttgggta gctctatctg
     4621 gaatttcatc ggaatttttt tcaaaaatat ctttaacgga tgcagggagt atgttaatat
     4681 ggttcctgac aaaatcactt tggctacaag ttaatgttaa attcaaagct gattaattaa
     4741 cagaactcag tttagggcac agttatgtgc ccttttaaag ggggatgctc taaattgagt
     4801 gcttagagat ggtaagagtc tctgttgaat atcatcatct caacttgcaa aatgtatttg
     4861 tactaagaaa ctaaaatata tttagcatta ctttccttta ataacagtcg tatgactaaa
     4921 gttcgttgca tattaaacga tgatatctac atacatgatg ctggatatgt aaaaatgtaa
     4981 attcaaattc aatcaattat atggaaaata gtaagaaagt ttatgtgggg atgagtgcgg
     5041 atatgataca tcctggtcat cttaatataa tccgcgaagc ggcaaaactt gggtgtgtaa
     5101 cagttggcgt gctgacagat gctgctatag caagttacaa gcgtttacct tatcttgact
     5161 ataatcaacg atcagaaata gttcgttcct tgaaaggagt ggataatgtt gtcccccaag
     5221 aaacattgga ttatgttcct aatcttgagc ggttgaagcc tgattttgtt gttcatggag
     5281 atgactggat gcagggagtc cagtccaatg ttcgtaatcg ggttatagaa tgtctgaaac
     5341 aatggggagg aaaagttgtc gatatagctt ataccaaagg cttttcttct tccgcagaaa
     5401 atgaacgtct gaaagagata ggaactactc ctgaaatccg tcagaaacgt cttcgtcgtt
     5461 taattaatgc caagaagata gttcgcatat tggaatccca taatggcttg accggtttga
     5521 tagcagaaaa tgtatctgta atcgttaatg gcgttaagca tgaatttgac ggtatgtggt
     5581 caagttcatt gacagactct actagtaaag ggaagcctga cattgaagct gtagatttga
     5641 ccacacgttt gcatgacttg aacgacacgt tggaatgtac aacgaaacct gtcatattcg
     5701 atggagatac gggcggtaaa attgaacatt ttgtattcac agttcgtacc ttggagcgct
     5761 taggaatttc tgctgtcatc atagaagata aggtaggttt aaagcagaat tctttgttcg
     5821 gtacagatgc ggttcagatc caagatacta ttgaaggatt ttgtaataag atccgtacag
     5881 gaaaaaatgc acaagtgtcg gacgatttta tgataatagc ccgtattgaa agcctgattg
     5941 ccggaaaaag tatagacgat gcactggcgc gtgcggcggc gtatgtggaa gcaggtgcag
     6001 atggcattat gattcatagc aagaataaaa gtggggatga tattaaggaa ttttgtcaaa
     6061 gattccgggt tgctaacgta tctactccca ttgttgtagt acctactact tacagtcaca
     6121 taacagaaac cgaattggct tcatggggtg tgaacgtagt aatttatgca aatcacatgt
     6181 tgcgaagtgc atacccctct atggttaact gcgccaaatc aatccttatg cacgaacgct
     6241 cacaggaagc tgttaatgat tactgtatgc ctatcaagga gattttggaa cttatacccg
     6301 gaacaaaaaa aacactaaaa tgatttcacc tgattttttt attaatagcc tttcccagag
     6361 aggcattgat ttctttgccg gagttcccga ttcattgctg aagaatatct gtgcctatat
     6421 tgcagatcac aaagacggac atcataatat cattgcagct aatgagggtg cagctgtagg
     6481 tttggctgcc ggacattatt tagctaccgg tcatatacct gttgtctata tgcagaattc
     6541 cggtgaagga aatatcatca atccactggc gtcgcttacg gataaagatg tttatagcat
     6601 tccactcttg ctgcttatcg gatggcgagg aatgccaggt gtgcatgatg aaccacagca
     6661 tgtcaaacag gggaaagtga ctatcccgtt acttgatgta atgggcatta agcacgttgt
     6721 gatgagcaaa gatgaaaaag aattgttaaa acaaatagaa gatgccctct tttttatgga
     6781 aacaaaaaat gaagcttttg cttttgtgat agaaaaagat acattcgatt cgtatgaatt
     6841 gcaatcaggc agtacttcaa cattgtcaat gagtcgtgag gaaaccattc aggcaattgc
     6901 ttcatctatc ggtcaagaag actgcattgt gtctactact ggtatgattt ctcgtgagtt
     6961 gtttgagcat cgtacccaaa tgaaacaagg tcacgagaaa gattttctca ctgtaggttc
     7021 catgggacat gcttctcaaa tagctctagg tatagcattg gaaaagacag accgtaggat
     7081 ttggtgcttt gatggcgacg gagctgtaat tatgcacatg ggttctatgg ccattatagg
     7141 gagcaaacag ccgaaaaatt atattcatgt agtctttaac aatggtgctc atgattccgt
     7201 aggtggccaa cctacggtgg gcttggatat tgatttgccg gggatagccc gttccgtaag
     7261 atacaatgcg gttcatacgg tttctgatat gaacggtttg aaaaaagttc tgtcggacat
     7321 tcggttggag gatggtcctg ttttgctgga agtgaaagta aggaaaggca atcgtaagga
     7381 tttgggccgt cctactacca cgcctataca aaataaagaa gcttttatgg ggttcttgca
     7441 agataaagag ttgaattaat tatgcaagaa tattatatcg gaccagactt gaacactcaa
     7501 ttggctgctc ttctgcagaa actaaatgta acaaaggtgt tcttggtaag aggcaagaag
     7561 tcctatacat cctgtggtgc atcggatgtg atggatgccg tattaagcgg aaggggtata
     7621 aaaactgtct gtttttttga cttcttgaca aaccctagag ttgaagatgt caggaaaggg
     7681 gttcttctat gcaagtcaca atgtcccaat atcatattgg cggtaggcgg tggcagtgca
     7741 cttgatatgg ctaaactgat tcgttaccat atatataaag aaacagatag ctatattccg
     7801 ctagtggtta tccctacaac agctggaaca ggtgcggaaa caacccattt tagcgtgtgt
     7861 tatataaatg gggagaagca gtcgatagct gattctgcaa tgcttcccga ttatgctttt
     7921 gtctgttcgg agttgactag ccataatgat gcttatctga cagcttgtac aggatttgat
     7981 gctgttgcgc aagctataga atcctattgg agtgtgaatt caacggatga aagccgtagt
     8041 tattcgttga aagcattagg tctgttatgg aagcaattgc ctttgctgat aaaaaacttg
     8101 aataataagg agctaagaag tgaagtcgca gaaggggcgt actatgcagg tcgtgctatt
     8161 gatataacga ctactactgc gcctcatgct ttttcttaca aattcacaag tctgtatgga
     8221 ataccgcacg gtcatgcggt ggcactaact tttccatact tttttgcatt gaatctttgt
     8281 ggtgaaagac tacaatctac attgaatagt tatgaatatg gacaaagaat gaagttgttg
     8341 gtacaatttc tggatgctga tagaagtgac ttcttgtctt gtcagctgca catgagtact
     8401 tatatttctt cattgggttt gtctgcgaaa gcattaacat tcgatgaatt agcttctgct
     8461 gttagctctt ttaatgaaca aagggggcgg aataatcctg ttgtcattga tgaggaggta
     8521 aaaagcggat tacagaatta ttttatggaa ttaaaagagt cggacaaaga ataggttgat
     8581 cctaaccatt tccaatttaa attattaatt atgcgtattc aaaatttgta ttataagcta
     8641 ggggggaaaa aaggaggttt ccttcaaacc aagtggagtg gatatataca aaaaaaaacg
     8701 gttaagagaa atagaaagct attgcaggat aaaggaatat gtgctcttga tgctatgtcg
     8761 gcagcctgta aagaagctgg tgtcagcttt ggaatggaat ttggaaccct gcttggagcc
     8821 tatcgtaatc aagggtttat tccttatgat gatgatatgg accttaccat gtgggcagaa
     8881 gactgttcta gggattttga aaatgtacta cttaaatatg gtttctataa aaaaagagct
     8941 ttctatcttg taaccgtaga ttctaatgga aagagaacaa ggaagctgac ggaaatagca
     9001 ttggattacg atggattaca agttgacata ttcttcagtt tcagaaaaac ggaaataaca
     9061 cgctcgattt ttgtttattg ccctcctgtt gtaaatgaaa aaatgacggc tcgtgaattt
     9121 gtactgccta tagggctttc tcctcgatta gtgactgtaa ggaataaaca atatccggct
     9181 tttgcagacc ctcacaagac tctttcttta atttatggag aggattttat gattccacgt
     9241 aagaatgcca gtgcgacaaa aagtattcaa tcaaatgtaa taattcatga tatgtttgta
     9301 gcttatggag aaggttttat gttagagtag tgtggttgta gacttttatt tctttccatg
     9361 aagagaacat cgggttttgt tgctgttatt tggagtttga ttgaacggtt gtcaagtcag
     9421 gtaataagtt tccttttggg tattgtatta gcgagattgt tgtcccctag cgattatggt
     9481 atcgttggaa tgacaatgat ttttatatta ttgtcaaatg tgtttattga agcaggcttt
     9541 gccaatgcat taatacgtaa aacaaatcga actgagcagg atttgtcaac agcattctat
     9601 tttaatgtgt tgattggcat attggcatat tgtatattat ggattggttc accgtttata
     9661 gctgattggt tcaaagaacc tcttttgtct ttattaatta ggatatcagg tgtcaatgtt
     9721 ttattaaatt ctttatgcat cgttcaaaca gccttgttaa cagcgaattt agatattcgt
     9781 cggcaaacaa tcattaattt gtgtgggcaa atacctgcag ggctgataac agctattttg
     9841 gcgtataatg ggttgggagt ttatgctcta gttttccaaa caataatagc ttcgtgcatt
     9901 agggttatta tgttatggct ttatactcca tggagacctc aagaaaaatt taatagagaa
     9961 tcttttctct ctttgtggaa ttttgggagt aaattactag gtgctaattt aataggaaca
    10021 gcctttaatc aggttagttc tgtgttaatt ggcaaatata taggaaaaag tgatttggga
    10081 tattactcca aagcgtcaaa tctatgtgga aatattgata gcgtttcatc gggagttgta
    10141 cagaaagtgg cattgcctat gttgtctgaa tttcaaaaag acaaagttct attatcagag
    10201 aaatttcgtg aaatgatgcg tttgcttatc atgggtatgg cgccattgat ttcttttttc
    10261 tgctttacag catctgacat tattgtaata ctttggactg aaaagtggat tcagtgtgct
    10321 ttcgtatttc agatacttat agtaggggca gcctttaatc ctataggaca catgagtctt
    10381 agtttaatgc agacagttgg aaattctgca ttaatattaa aattggaagt ccctaagaaa
    10441 attatctatt gcatttattt agctataggt ttctgctatg gcttagtcgg tttggctgtc
    10501 gcccaagtat taatcaatat aacaggagct cttattaata tgtgggcaac aaagcgtatc
    10561 gtcaaatata gttatatgcg acaaatagta gatgttttgg gttatatggt gattgctttt
    10621 attgtgggct atatatggtt taatatgata catactggat atatgttctt taatatttta
    10681 ttaatgttta tgttgattgt gtttacttat tttgcaatac ttgttatgat taaggatgca
    10741 attttaatta aatatgtaag aaaaataatt ggactctagc tattaaacct gtttagatga
    10801 ttttttttct tctttcatat tcgtgcatca tccattgttt ctgtatcata gaaatgctac
    10861 ccattctatt tcagcctcaa aggagtaata tccttggagt tagtatttga tgcggaagag
    10921 cacaaaaata acaatatgca atattatgcc atcaactata tgattaaaca tacgattctt
    10981 ttatgaatat tatctgcgtt ttcatctttt tgataatcag cttactatta attgtaaatt
    11041 tcaaatgtac tttcatggtg gtgtctgcat gtagtatggt gttaggctgt atgaatggag
    11101 tgggaccttt tggtatgtac caagctgttt caattgctgc attcagtatt tttatgttgc
    11161 ggtattttta ttggaaggat atgcgaactt atccgctctt gttcagctca atattattga
    11221 ttgtatctta tgtgttgagc aatcattacg ccgtataccg tcattacggt tcattggttt
    11281 cctgcatagt ggtagatgtg gcttcactgt ttgtattcta tcaaattata agtaaaaata
    11341 gccgatatat atttatatat ataagaactt gcgttatttt gtcgttggtt gttggtgtat
    11401 ataccttggt agaaacaata atttccagta accattatat gttcattgtc aattcattgg
    11461 aactatattc tcaagacatc atcgtagagg atatacgttt tggcatgaaa cgtgcgcaag
    11521 ctattttcgg catgcacact acgttaggag gtttctccac tatgatggct ggacttttac
    11581 tttgggtacg cttgaattgt acgctgtatg taaagaagtt gggaaagaaa aagctttcaa
    11641 tagctattgg cttgatgatt atagccgtgt ttcttacagg tacgcgtagt acgatagctg
    11701 gactggccgt agtgttaatg tcctttttca gctttaagca tataaagatg aagtatgtat
    11761 tcatagcaat tgtctcagtg gtcataggtt ttatggcttt ggatgcatat cttgataaga
    11821 taatcctttc atttaccgat acggaaagtg taggaggaag caatactgat atgcgttcca
    11881 tccagttcga actggcagct ttgttcatga tgcagtctcc tttcttggga aatggtatca
    11941 gctatacatt tgaatatgta gccgataagt ataaggagat gtgtggtgcg gaaagtttat
    12001 ggattcccat catgatagac ttcggcatat tgggaattac agctattatt gttttcatta
    12061 tacaagtggg gtattacatt aagaaatact gcgaaattcg attgcttttt ttcttattag
    12121 gtatattggt gttcaactca ttgagttcta taccagcttt ttcttttacc caattatttt
    12181 acctgtttgt tataattgca tttttaaaaa aatatcaaga atctatatgc aactctccat
    12241 catcattccc gtctataaag tagagaaata catacgggat acattgcaaa gtatctatcg
    12301 tcaacagtac gacgagaacc tttttgaggt gattgtgata aacgacggta cacccgatga
    12361 ctctatgcgt atagtggctg aatttacaaa taagcatgcc aatctgcata ttatcaatca
    12421 aaaaaatcaa ggattgagct gtgcccgcaa tgcggggttg aagatagccc aaggtgaata
    12481 tgtatggttt gtggacagcg acgatactgt gactgaggaa agtataggga aggtcattga
    12541 atgcatagag agaagtaagg cggatgtgat aggttttagc atactcaaag tcagtgaagc
    12601 gaatagagtg tctgaagtgg aatcagccat ttggaacgaa cattgtcgtt tctcatctaa
    12661 ccaaattgtc tgtgacaaaa gcattttatt ctcacttcat acgggtgctg ccgttcgcta
    12721 tgtttacaga cgggctttcc ttcaaatgaa tcatcttcgt ttttatcccg gcatcctcta
    12781 cgaggaccaa gaatttcttc ctcgcgtatt cagcttagcc aatagctttt acatttcttc
    12841 attcatttcc tatcgctatc ttttgcgctc atcaggctct atcatgtcgc agttctcgtt
    12901 gcgctcatta cgtgatacgc tcaccattgt gcgtagctat gagacatggc tgcaggaaga
    12961 gataaaagga aaatcagcct tgataaatgc ttatatcaat gggtgcgtct ttaatcatac
    13021 ttactggttg ttgtcgttta aggctgttac ctttcgggac gaacagaaag aatttatgcg
    13081 cgaccattat gctgaaatac ggaggaagtg tctgacagca gggtggaagt cgctaaaagg
    13141 aaatttcaga ctgacgcgtg cggtccgcct cctgatggta ttcctcattc catatcacct
    13201 cataaaatag ataaacttaa attattaatt atacattcaa gtaaatgaaa agatttttat
    13261 tacttcttct cttggcgttt gccatgtggg aactgcaagc gcaaattccc tactttgcca
    13321 gtacggccgg tgatgggaaa ctctatggat acacttcact gaaactacgt cctggtatca
    13381 atacacaaga gacttatacc acattccaat acggcattgg aaattctgta gctttgggta
    13441 cggatatcta tacaggagta ggttcaaatt atatgggatt cctggcccgt tatggtgtgt
    13501 cactgagtaa atggttcaat gttggtgcac agtttactcc atcgtttaat ttaagccata
    13561 actttgagtt tggt
//
