LOCUS       c00032_gnlPro..        16539 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCOLEIIN_32.
ACCESSION   c00032_gnlPro..
VERSION     c00032_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 19:31:39
            Original ID  :: gnl|Prokka|KCOLEIIN_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16539
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16539
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8410:11959](-)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(8411..11959)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16539
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16539
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             297..3134
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.6e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_1"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4.3e-20, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRMMGYTKWIAVLLCLLGMTACRQDTHRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLAMN
                     ILEKKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGDQH
                     RMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQIDVLSSFEGWNESFLAAARKKH
                     IHFSFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLTKEDTRWIR
                     FTVANTGSMISAEHIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEKQG
                     TVFTVDLPVQTCETILAEDSLKSSISAVPLNPASPGSPASSNLNETLAAEEEELEKGYD
                     SSKPSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGI
                     DGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRN
                     LIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGLS
                     RVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYR
                     EQFGESPTDLLKRKG"
     CDS             complement(3215..4603)
                     /locus_tag="ctg32_2"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLFGV
                     FAFSSCEKNLYDESKQPEKEIQVKDLDIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEA
                     CSKEEKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNETKKVAIPVNADRSFSLNIA
                     NDAKSKSNTTPSITRGHDIEDDIQLAKGVIFHPKDGWGTIMFEDQFPSLGDYDFNDFVV
                     NYKVQFQGIRKVDKKYTAQYIQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETK
                     NVIPAIDGVELVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITL
                     KKRKEVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPVYTNGDEEDD
                     NYYFSAGRLIWGLRVPGNAAHAIEKANFLEAYKGFAKWAQSSGKNEQNWYNQGNADKSL
                     LIHN"
     CDS             4687..5025
                     /locus_tag="ctg32_3"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMPQ
                     CSRMVGRALKQIPDDLSVPCHRVVNASGRLVPDWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVSE"
     CDS             5324..6550
                     /locus_tag="ctg32_4"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGHEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTAGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKAEIN
                     EIIQNAIDL"
     CDS             6547..7371
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg32_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.4e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAINAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             7392..8258
                     /locus_tag="ctg32_6"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSENK"
     CDS             complement(8411..11959)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_7"
                     /sec_met_domain="PFOR_II (E-value: 5.5e-19, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 6.4e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 5.7e-32, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.8e-12, bitscore: 37.6,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.2e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.6e-05, bitscore: 14.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.4e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGANFEMLKAVGKQFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(11992..13170)
                     /locus_tag="ctg32_8"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             13333..14535
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARRMASELALLPMWYA
                     EEGSAVLASSAYNLDYLKQMQELLGVSIHLMTEPELAVGPDLDIRPWGWDVALRKRLLG
                     LGVDEALLPSMEQLNGLREYSHRSKAVSLLPELQLNEYFCGESYYLKALEEWKTFVEER
                     ECCLLKAPLSGSGKGLNWCKGIFTPFISGWCTRVAASQGGIIAEPIYNKVEDFAMEFYS
                     DGTGEVTFMGYSLFHTGKSGMYEGNRLLSNEAIWKQLSQYVPSKVLTDLENCLKYRLSA
                     LVGTVYKGYLGVDMMICRFPENEKPVFRIHPCVEINLRMNMGVVARFLYDRYVHPGSIG
                     RFVIDYHPSEGEALQEHERMSATYPLKIREGRVYSGYLPLVPVHRRSCYRAWIWVTPDN
                     I"
     CDS             complement(14546..16102)
                     /locus_tag="ctg32_10"
                     /transl_table=11
                     /translation="MNDLLRKLPIGIQTFEKLRKGDYLYVDKTELVWKIAYTSTPYFLS
                     RPRRFGKSLLLSTFEAYFEGKKELFEGLAIEKLETKWEKHPVLHLDLNAEKYDSPERLY
                     DILSRQLTLWEIQYGKGIDENTLSGRFSGVIRRAYEQTGSSVVVLVDEYDKPLLQALGN
                     DVLLDEYRKTLKAFYGVLKSADRYLRFVFLTGVTKFSQVSVFSDLNQLQDITLWPDYGT
                     LCGITLQELLDTFQPEIKILAANNSISYDDAVQRMTRLYDGYHFCINSVGIFNPFSVLN
                     VLKSKVFDNYWFQTGTPTFLVEMLQETEYDLRTLLDGIEAPSSMFSEYRVDSNNPIPLI
                     YQSGYLTIKDFDREFGNYLLQFPNDEVRYGFINFLVPFYTGVRNSDQGFYIGKFVQELR
                     SGDYDAFLTRLQAFFADFNYELNEQTERHYQVVFYIVFKLMGQFTDAEVRSARGRADAV
                     VKTPKYIYVFEFKLHDTAEAALKQIDDKGYLIPYQADGREVIKIGVEFSAEKRNISRWL
                     V"
ORIGIN
        1 ctttgttaac cttaaatcta atactatgaa aaacacattg caaagatacg gacttctgct
       61 aaatctgcaa ataatccaaa taaaaagaga tgttttataa catttattga gtgtttgtct
      121 tacgctttat acttttgtta ataatttccg attgaatatt gggaactgtt ttgcatttct
      181 ttggagggta atgatgagaa taattgggtg atagatagca tactcacagt tttatttctt
      241 atttttgttc tcaatcgtct atttaggtca tagaaagaaa tacgaaaaaa atgagaatga
      301 ttagaatgat gggatatacg aagtggatag cagtcttgct ctgtcttctt ggcatgacgg
      361 cttgtcggca ggacacacac cgtttccgta tcggggtggc gcaatgcagc gatgactcct
      421 ggcggcataa gatgaatgat gaaattctcc gcgaagcaat gttttatgat ggagtatcgg
      481 ttgaaatccg gtcggctgcg gatgataatc gtaaacaggc ggaagacgtt cattatttta
      541 tagatgaagg ggttgactta ttgattatct ctgccaacga agcggccccc atgactccga
      601 ttgtagagga agcctatcaa aagggaatac ctgtcatcct ggtagaccgg aagattcttt
      661 ctgataaata tactgcttat attggtgccg acaattatga aataggacgt gcggtaggca
      721 attatattgc gtcaagcctg aaaggaaaag ggaatgtggt ggaacttacc ggactgggtg
      781 gctcaactcc tgccatggaa cgccatcaag gatttatggc tgctatcagt aactttccgg
      841 atatcaaact gattgataaa gcggatgctg cgtgggagcg tgaaccggcg gaagtggaaa
      901 tggatagtat gctccgtcgg catccgaaga tagatgccgt gtatgcgcat aatgaccgta
      961 tcgctccagg agcttatcag gctgcaaaga aagtgggacg ggagaaggaa atgatttttg
     1021 tcggtatcga tgctctcccc ggcaaaggca acggattgga aatggtgctc gacagtgtgt
     1081 tgaatgcaac ttttatttat ccgaccaatg gcgacaaagt gatgcaactg gcaatgaata
     1141 tccttgagaa aaagccttat ccccgggaaa cggtcatgaa cactgcggtg gtcgaccgta
     1201 cgaatgcgca tgtcatgcaa cttcagacaa ctcacatctc ggaactggat cagaagattg
     1261 aaacattgaa cggacgtatc ggcggatatc tgtctcgggt tgctacacag caggtggtga
     1321 tgtatggcgg tttggttatt cttctattgg tggcaggctt attattggta gtctataaat
     1381 ctctccgtgc taaaaatcgt ctgaataagg aactttccga gcagaagaaa cagctggaag
     1441 agcaacggga caagttagag gaacaacgtg accaattaga agaacagcgg gacaaactgg
     1501 aagagcaacg ggatcagctc atccagcttt ctcatcaact ggaagaggca acgcatgcca
     1561 aactggtgtt cttcacaaat atatctcacg atttccgtac tccgcttaca ttggttgccg
     1621 atccggtaga acatttattg gccgatcata cactaagtgg agatcagcat cgaatgttga
     1681 tgctgattca acgaaacgtg aatatcctct tacgtcttgt caatcagatt ctggatttcc
     1741 gtaaatacga gaacggtaag atggaatata cacctgttca gatagatgtt ctttcctctt
     1801 ttgagggctg gaacgaatca ttccttgcag cggcccggaa gaaacacatt catttctctt
     1861 ttgataatat gccggatacg gattaccata cattggcgga tatggaaaag ttggaacgta
     1921 tttattttaa tctgctttcc aacgcgttca agttcacacc ggaaaatgga aagataacgg
     1981 ttcgtttatc ttccttaacg aaagaggata ctcgctggat tcgttttact gttgccaata
     2041 ccggttcaat gatttccgcc gaacatattc ggagcatttt cgatcgtttt tataaaatag
     2101 acatgcacca tgccggttcg ggaatcgggc ttgcattggt caaagctttc gttgaattgc
     2161 ataaaggtac aatttctgtg gaaagtgatg aaaagcaggg cactgtcttt accgttgatt
     2221 taccggtaca gacttgtgag actattctgg ccgaagattc tctaaagtca tcaatctctg
     2281 cagttccttt aaatcctgct tctcccggtt ctcctgcctc ttccaacctg aatgaaactt
     2341 tagctgccga agaagaggaa ctggaaaaag gctatgattc ttccaagcct tccgttttgg
     2401 taattgatga taatgcagat atccgttcgt atgtacgcgg attactccat accgattata
     2461 ctgtaattga agcagcagac ggttcggagg gcatccgcaa agcaatgaaa tacgtcccgg
     2521 acttgataat ctctgatgtg atgatgcctg gtattgatgg aatagagtgt tgtcgtcggc
     2581 tgaaaagcga actgcaaacc tgccatatcc ctgtcatctt attgacagcc tgttctttgg
     2641 atgaacaacg gattcaggga tatgacggag gtgcggattc ttatatctcc aagcccttca
     2701 gttcgcaatt gctgttggca cgcgttcgta atctgataga ttcacatcgc cgcctgaaac
     2761 agttctttgg tgacggacaa acgttggcga aagaggatgt ttgcgatatg gataaagact
     2821 ttgtggaaaa attcaaggct ttaattgaag caaagatggg agattcaaat ttgaatgtag
     2881 aggatttggg taaggatatg ggattaagtc gtgtgcaact ctatcgcaaa ataaaatccc
     2941 tgactaatta ttctccgaat gaattgcttc gcatcgctcg cttgaagaag gctgcttccc
     3001 tgcttgcttc gtcagatatg acagtggcgg agattggtta tgaagtcggt tttagttctc
     3061 cttcttattt taccaaatgt tatagagagc agtttggtga aagtccgaca gatttgctga
     3121 aaaggaaagg atagaatcaa aactattcac gtcagaatac aataaatccc ggtaacttga
     3181 attttcaatg tttaccggga tttattgata tgtgttagtt atgaatcaat aaacttttat
     3241 ctgcgtttcc ttgattatac cagttttgtt cgtttttgcc actactttgc gcccattttg
     3301 cgaatccttt ataggcttcc aagaaattag ctttttcaat agcatgtgct gcgttgcctg
     3361 gtactcttaa tccccaaatc aggcgtcctg cactaaaata ataattatca tcttcttcgt
     3421 ccccgtttgt atataccggt agcagatttt tatcattgaa tggatattgg taagtgatcg
     3481 gttcaatacc attcatatgg atttctgttc cgctatcatt acgttttaaa tacaagtcga
     3541 attcatcgcc ttctaatatt tcctttactt cttttctctt ctttagggtg atcagaatat
     3601 tgatctccgg taaatcactt gttgctacca aagcattctt ttctgtatta taatattggc
     3661 tgcctgcagg tttagccaga ttcttaatta aagggctgta atcaatgata agatgtttat
     3721 tggggacaag ttctactccg tcgatcgcag gaatcacgtt tttagtttca taaacttcta
     3781 tactttccac ttcgtcagaa tctatttctt tcagtcttaa ataaggggaa taagggaata
     3841 ttcctccgat agcttttaga cgtaacccta tttgtatata ctgcgcagtg tattttttgt
     3901 caacctttct aataccttgg aactgcacct tataattgac tacaaaatca ttaaagtcat
     3961 aatctcctaa tgatggaaat tggtcttcaa acatgattgt tccccaacca tctttgggat
     4021 gaaaaatgac tccttttgcc aattggatgt catcttctat atcatgccca cgagtgattg
     4081 acggggtggt gttagatttg gatttggcat cattagcaat gttcagtgag aaacttctat
     4141 ctgcatttac aggtatggct acttttttgg tttcattggt gctggttttg tactgggcat
     4201 acaatgtatt tacgtaggtt gggatgctca aagggagact tgaaatttct gtatctacag
     4261 gaatgtcggc tattttctct tctttactac atgcttcatc caaaaagaag gaaaccatag
     4321 tgggggtagt agcagctact gttcctgcgg ctacttgagt taatttccat tgaaagcctg
     4381 cgggtatatc caggtctttt acttgaattt ctttttcagg ttgcttgctt tcatcataaa
     4441 ggttcttctc acaggagctg aaagcgaata ctccaaataa acaagaagcg aatagaattg
     4501 tcttcttttt cataacagca gtgcttgttt tgttaataat agggttgctt ttaatgggta
     4561 caaaggtcgg gattatttgt aaataaagca aataaagttg catattttat ttgaaatgct
     4621 tttattattt gcaaattctt ttctttttat ctagttttgg aactgaaata aagtaatgtt
     4681 tgagtgatga aagattataa agtagacaaa gcgagtctct ccgcatcctt ttgtcaagag
     4741 gtgtatcagg ttgttcggga aattccggta ggtaaagttt ctacctatgg gggaattgcc
     4801 gcattattgg gaatgcctca atgttcccgt atggtggggc gtgctttgaa acagattccg
     4861 gatgatttat ctgtgccttg tcaccgggtt gtcaatgcat cgggacgcct tgttccggat
     4921 tggacagagc agaaacaact cttgttggaa gaagggatct ctttcaagca aaatggatgc
     4981 gtagacttga aaaagcatct ttggaattac tccgtatctg aatgaaattt gcatatttaa
     5041 tctattttcc ttatctttgt gccaacaaaa tgcaagaaca gactgttatt tatttatgaa
     5101 aatactgttt tctactgttc attgagagga taatcttatc aaattctatt ccttttaaac
     5161 tacttagtct gttttcttta accatttaaa aaacgtcgga tcgtcatgtt accatgtgac
     5221 atgactgaac catgcgaaca ttcaacttgt ttatcgtaag tgagaatgag gaacgcggca
     5281 gttgaaaaca aaacaaatat tataatctaa accaatatat tatatgagta aaatagaaat
     5341 aaaggatttg taccttatct ttggtcacga gaagcagaaa gcactcaaga tgttgaaaaa
     5401 agataagagt aaagaggaaa ttctgaaaga taccggttgt acggtaggag tgaaagatgc
     5461 caatctttca attaatgaag gagagttttt tgtgataatg ggactctcgg gaagtggaaa
     5521 atcgacatta ctgcgttgta tcaatcgtct gatacgtcct actgccggac aagtgcttgt
     5581 aaacggagta gatatatcta aaatatccga aaaagagtta ttgcaagttc gccggaaaga
     5641 gttggcgatg gttttccaga attttggtct gttacctcat cgttccgtat tgagcaatat
     5701 cgcgttcggc ctcgaacttc agggagtgaa aaaagaggaa cgtgagaaga aagcgatgga
     5761 aagtatgaag cttgtcggat tgaaaggata tgaaaatcag atggtgggcg agctttccgg
     5821 tggaatgcaa cagcgtgtcg gactggcccg tgctctggct aataatcctg aagtacttct
     5881 aatggatgag gctttctctg cgctcgatcc tctaattcgt gtgcaaatgc aggatgaact
     5941 gttggctttg caatcgaaga tgaaaaaaac aattgtcttt attacccatg acttgagtga
     6001 agcgattaaa ctgggcgacc gtattgctat tatgaaagac ggagaggtgg tgcaggtagg
     6061 tacttcagaa gaaatactga ccgaaccagc taacgattat gtagcccgtt ttgttgaaaa
     6121 cgtggacagg agtaaaatta tcaccgcttc ttctttaatg attgacaaac cactggtggc
     6181 ccgtctgaag aaagagggac ctgaagtatt gattcgtaag atgcgtgcga agaatatcac
     6241 cgtattacct gtcatagacg ccgatgataa actggtcgga gaagtacgtc tgaacgacct
     6301 gcttaagtta cgtagcagac aggaaaaatc cattgaaacg attgtgcgta ccgaagtgca
     6361 ttctgtattg gaggatacag tgttggagga tatacttcct ttaatgacaa agagcaattc
     6421 gccggtatgg gtgattgatg agacgcatga gtttttagga acaatcccgc tttcctcctt
     6481 aatcatcgaa gtgaccggaa aagataaagc agaaataaac gaaataattc aaaacgcaat
     6541 agacttatga taaatatagg acaatatata gagatggcta tcaattggat gatggtacat
     6601 ttttccactt tctttgatgc cataaatgca ggcatcggta gttttattat aggattccaa
     6661 cacgtacttt ttggaatacc tttttatata accattctag tgcttgctgc actcgcatgg
     6721 atgaaggcag gacgtggtac ggcaattttc accgcattgg gattattact gatttatgga
     6781 atgggatttt gggaggctac tatgcaaacc ctggctctcg ttttttcatc tacctgtctg
     6841 gctctgattg ttggtgtacc tttaggagtg tggacggcaa acagtccgcg tgcagagaaa
     6901 atactccgtc ctgttctcga cttgatgcag acgatgcctg cttttgttta tctgattcct
     6961 gccgttttgt ttttcggatt gggagcagtg ccgggagtgt ttgccaccat tatctttgct
     7021 atgcctcctg tggtccgcct taccggattg ggaatacggc aagttcctaa aaatgtagtg
     7081 gaagcttccc gttcgttcgg ggctacccgt tggcagttat tgtataaagt gcagcttcct
     7141 ttggcgttgc caaccatcct gacaggtgtc aatcagacaa taatgatgtc gctttctatg
     7201 gttgtcattg ctgccatgat tgctgccggt ggtctgggag aaattgtatt gaaaggtatt
     7261 acccaaatga aaatcggact tgggtttgaa ggtggtatcg cagttgttat tttagctatc
     7321 atcttagacc gtatcacaca aggaatggca ggacgaaaaa ataagaacta aacggaaagg
     7381 ataaaatacg tatgagaata tataaaatag taggaatagt attgtcagct atgcttttgc
     7441 tggcttcctg tactaattca gacttagaga aaaagaaagt aaaaatagcc tatgccaatt
     7501 ggttggaagg tattgccatg agtcatttgg ctaaggtggt attggaagaa catggatatg
     7561 aggttgaact gcaaaatgct gaccttgccc ccatctttgt atctatgtcc ggaaagaaat
     7621 ctgatgtctt tctggatgcc tggttaccaa taacgatgaa agattatatg gatcagtatg
     7681 gagacagcat cgaatttctg ggtgaggtgt atggagaagc ccgtgtagga ctggttgttc
     7741 ctcaatatgt tacgatccag tctattagtg agctggaagc taataaagac cgtttctctt
     7801 ctgaaatagt aggaattgat gcaggagcag ggataatgaa gacgaccgat aaggccattg
     7861 ctgcttacgg acttgatggg tataccctca tgacttcaag tagttccacc atgctggctt
     7921 ctttgaaaaa agcgatggac aaaggagaat ggattgtcat cacggggtgg acaccacatt
     7981 ggatgttcga ccagtttgac ttgaaattct tggatgatcc gaagaaagta tatggagact
     8041 tggaagaaat acatgctatt gcatggaaag gattcagtga gaaagatccg tttgctgccg
     8101 aattctttgg taacatcaaa ctaacgacag aagaacttag ctcttttatg acagctatga
     8161 aggatgcccg gatggatgaa gaagaaatag cccgcaaatg gagggatgaa catcggcagt
     8221 tggtggatag ttggattccg aagtcagaga ataaatagat tggagcattg tgattcttaa
     8281 ttttaaatat aaaatagaca tgaactctag tgggaaaaag ggagtactgt ttatgttaga
     8341 cagagttcat acaataaaaa aacggtaatc ttctacaaga ttaccgtttt atatttatag
     8401 ggtattacta ttattcagca ccccagtttt ctctagccaa acgtttgtag ctgttgtaac
     8461 gccatttagc gttttcttca gcagctttga acagttcttc agcttcagta ggatattgtt
     8521 tcattacaga agcgtaacga acttcaccct tcaagaaacc ttggaaatct tcccagttcg
     8581 gttctttgct atccaattgg aatgggttct tgccttcttc ttccaaagcc gggttgtaac
     8641 gccacaagtg ccagtaaccg cacttaacag ctttttcttc ttcttcctgg ctcttaccca
     8701 taccggcttt cagaccgtgg ttgatacacg gagcataagc gatgatgagt gatggtccgg
     8761 gatatgcttc agcttcgcgg atagctttca gagtctgagc ctgatcagca cccatagcga
     8821 tctgtgcaac atatacataa ccgtaagtag tagccatcag accgaggtct ttcttacgta
     8881 cgcgcttacc agcagcagcg aacttagcga tagcacctac cggagtagct ttagaagact
     8941 gaccacctgt gttagagtaa acttcagtat ccagaacgag gatgttaacg tccttaccgg
     9001 aagcgattac atggtcaaga ccaccataac cgatatcgta agaagcaccg tcaccaccaa
     9061 tgatccactg gctgcgtttt acaagatatt gttgcagttc agcgatttgt ttgcagtggt
     9121 tacatttatc cttgttagct tcaacaaccg gaatgatctt agcagccaat tccttagtct
     9181 tgtccgcatc cagcatattg ttgatccatt cagcgaacag ttctttcact tcagcaggag
     9241 tgcaatcagc agcaatagcc tcgttcatca ctttcacgag acgagcacgc atcttttcgt
     9301 tagccaattc catacccaaa ccgaattcac agaagtcttc gaacagtgag ttagcccaag
     9361 caggaccgtg tccgttttcg tttgtagtat acggagtaga aggaacagaa ccagagtaga
     9421 tagaagaaca tccggtagcg ttagcaacca tttcacggtc accgaacaat tgagaaatca
     9481 atttcacgta tggagtttca ccacaaccag agcaagcgcc ggagaactca aacaacggag
     9541 tagcgaactg tgagttcttc acgttagcct tgatatcaac aagatgttgt ttagtcttca
     9601 cgttttcagc acagtaagtc cagttttcag cttgagccaa ttggctttcg aggtgtttca
     9661 ttgtcaatgc tttgccaccc ttcttcggat tacccggaca gatgtcagca cagttaccgc
     9721 aacccagaca gtcgagaacg tcaacctgga tacggaatgt cataccgtcg aattgtttac
     9781 ctacagcttt cagcatctcg aagttggcac ccttctgctc ttcagcgtcg agtacgaacg
     9841 gacggataga agcgtgagga caaacgtatg cacacttgtt acactggata cagttttcag
     9901 cattccattc aggaacgaat gcagctacac cacgtttttc gtatttagca gttccttgat
     9961 accaagtacc gtcttcgata cccttgaatg cagataccgg caacaagtca ccgtcttgtg
    10021 cattgattgg acgaactact tcgttgatga atgcaggatc gttgttttca gcttttgcgt
    10081 catccggaag gttagcccaa gcaggatcaa cagccaaagt cttgtattca ccaccacggt
    10141 caacggcagc atagttcttg ttaacaacgt cttcaccctt cttgccgtaa gacttaacga
    10201 tgaatttctt catctgctca acagcttgtt ctacaggaat aacgcctgtg atacggaaga
    10261 atgcagattg aaggattgtg ttggtacggt tacccaaacc aatttccagt gcaatttgtg
    10321 ttgcgttgat atagtataca gaaatgttgt tctgtgcgaa atatttctta accttgttag
    10381 gcaggttctt agccagttct tcaccttccc agattgtgtt cagcaggaaa gaaccgttct
    10441 tacgcaaacc acgagttaca tcgtacatgt gcaggtaagc ctgaacgtga caagcaacga
    10501 agttcggagt gtttaccaaa taagtagaac ggatcggatt atcaccgaaa cgcaagtgag
    10561 aacaagtgaa accacccgac ttcttagagt cataagagaa gtaagcctgg cagtgtttgt
    10621 cagtgttgtc accgataatc tttacagagt tcttgttagc acctactgta ccgtcagcac
    10681 ccaaaccgta gaatttagct tcgaacatac cttcgccgcc taaagcgatt tcttcttttt
    10741 gaggaagaga agtgaaagta acgtcgtcta cgataccgat agtgaagtgg ttcttcggca
    10801 ttggcatagc caagttttcg aatactgaaa gaatttgagc aggagtagta tcttttgaac
    10861 ccaaaccgta gcgaccgcca acgataaccg gagcattttc tgcaccgtag aagcagtctt
    10921 taacgtcaag gtaaagaggt tcaccgttag cacccggttc tttagtacgg tcaagaactg
    10981 cgatagtttt agcagtctta ggtacagcag ccaagaagtg tttagcagag aacggacgat
    11041 acaggtgtac ggcaaccata cccacttttt cgccgtttgc taccaggtag tcgatagctt
    11101 cgcgggcagc ttctgttaca gaacccatag cgataattac gcgttctgca tcttctgcac
    11161 catagtaatc gaacaaaccg tatttacgac ctgtgatctt agaaatttca ttcatgtatt
    11221 cttctacgat agcaggaact gcttcatagt agttgttgca tgattcacga tgttggaaga
    11281 aatggtcagg attttcagcc ataccacgag ctaccggttt catcgggttc agtgcgcggg
    11341 cacggaattc agccaaagct tcctggtcga tcagaggagc aagatcatca ttttccaaca
    11401 tttcaatctt ttggatttcg tgagatgtac ggaaaccatc gaagaagttc atgaacggaa
    11461 cgcgagattt gatggtagcc aagtgagcaa caccagccaa atccataact tcctgtacag
    11521 agccttcagc caacatagca aagccagtct gacgagctga cattacgtct tggtggtcac
    11581 cgaagataca caatgcgtga gaagccaatg tacgagcaga tacatggaat acgcaaggca
    11641 agaactcacc ggcaattttg tacatgttag ggatcatcag gagaagaccc tgggaagcag
    11701 tgtaagtagt agtcaacgca ccagcctgaa gagaaccgtg aactgcaccg gcagcaccac
    11761 cttcagattg catttcctgt accaatactg tttcgccgaa gatgttctta cgtcctgcgg
    11821 cagcccattc gtctacgtac tcagccatag tcgaagaagg agtgatgggg tagatagctg
    11881 ctacttcaga gaacatatac gagatatgcg ctgcagcctg gttaccatca caagtgatga
    11941 atttcttctg tttagtcata actaaattaa atatttaagt aaataaatct tttaatataa
    12001 aaagccgaac atccagagag gtatctggtt gccccgacct atttcagcct tatgcaacgc
    12061 gtatgttaca ttcggattgt tcttgatctt tgcgccttcc tggcaaattt tgaacggcat
    12121 tacttcgtct accataaaag agacgttttt atctccttta tgtaccttat ggtctttcca
    12181 taaagaattt gcaaagaatg tgtcgagcac atcctgctct tccactttca ccggatagat
    12241 ggaatacatc aggttggagt tgtgcatcat tatctttgaa ggttttttag ggaattcttc
    12301 ccctttcgga taaaccagat taatgagtcg cgcatctgcc agatacttga tatagttcat
    12361 caccgtggcg cgagatgtct gtatgtcgct tgccagttgg ctcacatttg gagctttcgg
    12421 cccgtcgaca gcgagcaaat atagcaattt ttttatcttt gaaagatatt tcagttcaat
    12481 ttgtttgatg agaagtatat ctacttccac catcatgttc atcgttttca gcagattctc
    12541 cgaaaagtta cgtttttcaa ggaagaacgg atagaatccg tggtgcagat aatcctgaaa
    12601 ataatccaac ggacggactt tggagagtac tcctttggca atctgttcgt gagtgctaag
    12661 aatttcttcg aggctatatg ccctgaattt catgcctgtt tgcaagttta ggaattcacg
    12721 gaaagagaat ccacgcaggt tatagctctt ggcgatatca cgtaattcaa gattttcttc
    12781 tttcagtcgc atcacggacg agccggtgaa gacaattttc aggttaggaa aacggtcgta
    12841 acacatgcgt aactctttgc tccattccgg atgtttgaac acctggtcga tcaacaatac
    12901 ttttccgcca cgtttctgaa attcgttggc gaagtctaca atgctgtggc ccgagaaata
    12961 gaagttgttc atgttgatga acagacagga acggtcgttc ccgaatttct ctttggcgta
    13021 ttggagaagg aaagtggttt ttcctacgcc acgtgtccct ttgataccaa tcaggcggtc
    13081 gctccagtcg atctcgtcca taagatcgcg gcgaacgggg gcattggtgt gctcaacgag
    13141 gtaggcgtgt gtgcggtaga atgattccat ttcagttctt tgtttttcgg gtggcaaata
    13201 tactgctttt tttaggattt gcaaagtaga gatggcaaaa ttgtgtgttt aattccaact
    13261 ttctgtttat tgtagtcatt cctgactatt tcctgtatat atttgcagaa taaagttttg
    13321 aattcatttg aaatgacaaa aaaggctctt tatatattca atccggaaca tgacttggcg
    13381 ttggccagcg gtgaaactaa ttatatggct ccagcttcgg ccagacgtat ggcttccgag
    13441 ttggctttgc ttccgatgtg gtatgcagag gaggggagtg ctgtattagc ttcttccgct
    13501 tataatctgg attatttgaa gcaaatgcag gaattgctgg gagtttcgat tcatttgatg
    13561 actgaaccgg aacttgctgt cggaccggat ttggatattc gtccttgggg gtgggatgta
    13621 gctttgcgga aacggctttt agggctgggc gtggacgaag ccctgcttcc ttctatggag
    13681 caattaaacg gtttgcggga atactcccat cgttctaaag ccgtctcgtt acttccggaa
    13741 ttacaactga atgaatattt ctgcggagaa tcttattatt tgaaggcact ggaagaatgg
    13801 aaaacttttg tggaagagcg ggaatgctgc ctgttgaaag ctccgctttc gggaagcggt
    13861 aaaggcttga actggtgtaa aggcatattt actcctttta tttccggttg gtgtacgcgt
    13921 gtggctgctt cgcagggtgg aatcattgcg gaacctatat ataataaggt agaggatttt
    13981 gccatggagt tttattccga tggtacaggt gaagtgacat ttatgggata ttccctcttc
    14041 cataccggaa agagtgggat gtatgaaggg aatcgtttgc tttctaatga ggcaatctgg
    14101 aaacaacttt cgcaatatgt cccttcaaag gttctgacgg atttggagaa ctgcttgaaa
    14161 tataggcttt ctgcgttggt aggaaccgtt tataaaggtt atcttggagt tgatatgatg
    14221 atttgtcggt ttccggaaaa tgaaaagccg gtttttcgga ttcatccctg tgtggaaatt
    14281 aatctgcgca tgaatatggg agttgttgcg cgttttttat atgaccgtta tgtacatcct
    14341 ggttcaatag ggcgttttgt gattgattat catccttcgg aaggtgaagc cttgcaggaa
    14401 catgaacgaa tgtccgcaac ttatccgttg aaaatcaggg aaggtagagt gtactccggt
    14461 tatttacctt tggttcctgt tcataggaga agttgttatc gggcgtggat atgggtaact
    14521 cctgataata tttaacttta tctgttcaca ccagccagcg actgatattg cgtttttccg
    14581 cactgaactc taccccgatc tttatcactt cacgtccgtc tgcctgatac ggtatcagat
    14641 agcctttatc gtcgatctgc ttcaatgccg cttctgccgt gtcatgcagc ttgaattcga
    14701 agacatagat atatttaggt gttttcacta cggcatctgc acgaccgcgg gcgctgcgta
    14761 cttcggcatc ggtgaactgt cccataagtt tgaagacaat atagaaaacc acttggtagt
    14821 gacgctctgt ctgctcgttc aattcgtagt tgaaatcggc aaagaaggct tgcaggcggg
    14881 tgagaaaggc atcgtagtct cccgaacgaa gttcttgtac aaacttgccg atgtaaaatc
    14941 cttggtcact gtttctcact ccggtgtaaa atggaaccag gaaattaatg aagccgtagc
    15001 ggacttcatc attaggaaat tgcaatagat agttaccaaa ttccctatcg aaatctttta
    15061 tcgtcagata gccactttgg taaattaacg gaatcggatt attggaatct acacgatatt
    15121 cggagaacat ggaagacggt gcttcgatcc cgtcaagcaa agtacgcagg tcgtattcgg
    15181 tttcttgcag catctcgacg aggaaagtcg gtgtgccggt ctggaaccag taattgtcga
    15241 acacttttga tttcaggaca ttcagtacac tgaacgggtt gaagatacct actgaattaa
    15301 tgcaaaaatg atagccatcg tagagacgtg tcattcgttg taccgcgtca tcataagaaa
    15361 tggaattatt ggctgcaagt atcttgattt ccggttggaa ggtatccaat aattcttgaa
    15421 gagtgatgcc gcaaagggtt ccgtaatcgg gccataaagt gatgtcctgc aactggttga
    15481 ggtcactgaa tacacttact tgtgagaatt tcgtcactcc tgtgaggaag acgaaacgca
    15541 ggtagcggtc ggcacttttc aatactccgt aaaaggcttt cagggtttta cggtattcat
    15601 ccagtaagac atcattacct aaagcttgca acagaggttt gtcgtattcg tctaccagaa
    15661 ctacgacgct gctaccggtt tgttcgtagg cacgacggat gacgccggag aaacgaccgg
    15721 aaagagtgtt ctcgtctatt cctttgccat attggatttc ccataaggtg agttgacggc
    15781 tgaggatatc ataaagtctt tctggggaat cgtacttctc ggcatttaaa tccagatgca
    15841 gcacaggatg cttttcccat ttcgtttcca gtttttcaat ggcaagccct tcgaagagtt
    15901 ctttctttcc ttcaaagtag gcttcaaagg tagagagaag aagactttta ccaaaacggc
    15961 gtggacggct caggaagtat ggagtagatg tataagctat tttccataca agctctgttt
    16021 tatctacata tagataatcg cccttacgaa gtttctcaaa ggtctgtatc ccgataggga
    16081 gtttacgaag caggtcattc attgttattt tccttttagt ggttcaaaga taatcattat
    16141 tttcgtaata tttcgttttc aatatctcaa agaacgggcg ttataatttt gtttaactgg
    16201 aaaattatca tttagctcat tcttgcacgg ttttcaccac agaggacacg gaggacacag
    16261 aggtgaattt gttttatgac ttacggttgt gaccctaatt ttaatgcgta atcctcctct
    16321 ataaagttga aaaaacatga aaacatctgc cacctgcaac caaacgcatg taatacagta
    16381 gttaataagt agttggagcg ttgcagatac ctgcgacaga taggttgcag ataaagtatc
    16441 tgcaacacag tataaacctt acataaacta attctccatg agtgcaaaag tttattgtat
    16501 acattaactt cccgtttcca ggcggggaac tgtcgtttc
//
