LOCUS       c00016_gnlPro..        13214 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPBMDOCB_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:28:31
            Original ID  :: gnl|Prokka|GPBMDOCB_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13214
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13214
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[243:3214]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      244..3214
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..13214
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13214
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             244..2472
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_1"
                     /sec_met_domain="Gly_radical (E-value: 3.7e-46, bitscore:
                     148.1, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1173.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKIFKDGLWSSEINVRDFVSHNITPYYGDASFLEGPTERTKA
                     VWNRCLEALAEERENNGVRSLDNVTVSTITSHKAGYIDKENELIVGLQTDELLKRAIKP
                     FGGINVVSKACHENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRMALYGIDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKDMK
                     VMGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSK
                     GTITESFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESLGGRLNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNLTVLWSPELPEGFKEFCAKVSIDTSSIQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARCNLAKALLLAINGGRCENTGTVMVKNIPVLTSDTL
                     KFEEVMDNYKKVLTEIARVYNEAMNIIHYMHDKYYYEKAQMALVDTNPRINLAYGVAGL
                     SIALDSLSAIKYAKVTARRNDIGLTEGFDIEGEFPCFGNDNDKVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATDEDRIENLVTMMDGYFTKGAHHLNVNVLN
                     RDMLYDAMEHPENYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             2486..3214
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 71.7;
                     E-value: 2.5e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_2"
                     /sec_met_domain="Radical_SAM (E-value: 1.3e-28, bitscore:
                     92.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIAGKG
                     GTPTPPEEIVRMAMSQRPFFGKRGGITFSGGEPTFQAKTLVPLVRELKEKGIHVCLDSN
                     GGLWNEDVEELFRLTDLVLLDIKEFNPNRHQTLTGRSNEQTIRTAAWLEEQEKPFWLRY
                     VLVPGYSDFEEDIRALGEALGKYKMIQRVEILPYHTLGVHKYEAMGQEYKMKGVKENTP
                     EQLEKAAEVFKEYFTTVVVN"
     CDS             complement(3207..3656)
                     /locus_tag="ctg16_3"
                     /transl_table=11
                     /translation="MRKISLIVIHCSATRVDCDFTAKDVDTAHRYRGFSCWGYHYYIRK
                     SGEIEPMRDEDTVGAHARGYNAISLGVCYEGGLDENGKAADTRTPRQKEALHRLVHELL
                     QRYPEAKVVGHRDLSPDTNYNGIVDPWERIKECPCFEVIGEFSIN"
     CDS             complement(3643..3810)
                     /locus_tag="ctg16_4"
                     /transl_table=11
                     /translation="MKEIVSRILDVIMYLIPFFGKRKRDRVVREVRYHTTCKEVCKVKT
                     TEREKEHEKD"
     CDS             complement(3870..4373)
                     /locus_tag="ctg16_5"
                     /transl_table=11
                     /translation="MAMTVSYSVVPRKNPAKKSEPAKYYAQAQASGELDFEELCEAITS
                     RSTCTETDVRAAISGILYEVKRALKAGRIARLGDLGSLQIGLNSEGAASVKEFSGSMIK
                     GAHLIFRPGKTLAELMKILSYQQVQTRAVAQAGAGDGGGEDPDKNPDSGGDGSGDEEAP
                     DPTV"
     CDS             4567..4797
                     /locus_tag="ctg16_6"
                     /transl_table=11
                     /translation="MNYKEDSFLIRTYTKAELAHLYNPHVCLKVALQILRRWIIYNLPL
                     LHELEQEGYRARNRLLSPKQVATIIHFLGEP"
     CDS             4884..6998
                     /locus_tag="ctg16_7"
                     /transl_table=11
                     /translation="MKHFTIFQGFYYAIAEMTEEEIVSTIGCFTYREKVEEIRRIFAEQ
                     GEKAANEKKKELPAIAFSASYRGRRTKVNLVKYLGHIVIDIDHLSKEELARILPIIKRC
                     DYTRIAFISPKGMGVKIIVRACHPDETLPETLQEIEDFHHAAYTRLVSFYTELCQIEID
                     TSGQDVARTCLFSYDPEIYFNPNADAFLVDQPQASYKVSNRKNLSGSKQQTPPDGPPTN
                     EDTALNAHSANASLVLTLTYYHNKSEKYIVGNRNNYLHHLSCTFNRYGIPQEEASAFIK
                     SQFTDFPADETASLINSAYAHTDEFNTCKLNGTQKRILRIEQYISEHYETRYNEVLHIM
                     EYRRRHPDTEKPEPFRILDEMMENSIWIEINELGYACTVKTIENLIYSDFSQSYHPIRE
                     YFELLPEWDGTDYIRILADSVQTSHQEFWAECLERYLVAMCAAATQENIVNHTVLLLCS
                     EIQNIGKTTFINNLLPPELRAYLSTGLINSNNKDDLAKITQAMLINLDEFEGMSGRELN
                     AFKDLVTRKVISFRLPYARRSQNFPHTASFAGTCNYQEVLHDTTGNRRFLCFHPYSIQF
                     ITINYAQLYAQIKYLLNKPGYQYWFTQADNERLEENNEAFIFHSPEEEMVLTHIRKPER
                     FEKVYYLTVSEIAELIRERTGYQYSIGSKIQLGKVMTKHHFESKKGNNGRRYAVFIIDI
                     EQVKSNRLYE"
     CDS             complement(7068..7370)
                     /locus_tag="ctg16_8"
                     /transl_table=11
                     /translation="MQINNHQIVDYDAVLDAKFGAEGTPERAEAEEKAYAFYTGQIIED
                     ARKKAKITQAELARRIGSDRSYISRVESGQTEPKVSTFYRIMNALGCKIEFSMIL"
     CDS             complement(7336..7689)
                     /locus_tag="ctg16_9"
                     /transl_table=11
                     /translation="MEKKRKIRTYGGYFEAFMETLTEKEQDKIQYGLLLLKTQERLSAK
                     FVKFIRDGVFELRTEYNNNIYRVFFIFDDGNIVVLFNGFQKKSQKTPGHEIDKAVKIKE
                     EYYADKQSSNSRL"
     CDS             7706..8122
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="MLFNYTTHFLVLYYFSSSSPQKVRGVREELKLFLFYFFISTFYIS
                     LKKIRMLEILSHSSHFLPFLSPKRRRKIGKTQPSFFNFPPHFQISPPIEADFRKYLLSL
                     MCKRSKESDMDNLMRKLPIGIQTFEDIRRKNILL"
     CDS             complement(8238..8549)
                     /locus_tag="ctg16_11"
                     /transl_table=11
                     /translation="MSTKNNMLTDISAELDKEFGAPGTPEREKFDEEAYAFYTGQILLD
                     ARREAKVTQSELAKRINATKSYISRIESGAINPSVGTFYRIINALGLKIEIVKPIMGI"
     CDS             complement(8521..8862)
                     /locus_tag="ctg16_12"
                     /transl_table=11
                     /translation="MRRKVIAYGQYYKDFLATLTEKEIQKVKYVLSLLGTEDRLPIKFI
                     KVIRDGLYELRISYNGNIYRIFFIFDEGQIVVLFNGFHKKTQKTPSSEIDKALKIKEEY
                     YEYKKQHAD"
     CDS             complement(8955..9209)
                     /locus_tag="ctg16_13"
                     /transl_table=11
                     /translation="MTPTVIEYRGDPKRYVSVILGAIDRGRLTYNGDANCEQTFRSLSS
                     VIDVISPKNGKALSIETLVSYEKKERAGEFSDYSEGKFE"
     CDS             complement(9227..9361)
                     /locus_tag="ctg16_14"
                     /transl_table=11
                     /translation="MENSLSDELFCSLKNELREVDAQISVHSKKLLELIDQKKELSSN"
     CDS             complement(9479..10837)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 153.4; E-value: 2.6e-47)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_15"
                     /sec_met_domain="MFS_1 (E-value: 2.5e-47, bitscore: 153.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKLLDFYKISPPVSGGETDPERSVRFKRIRWATFLSATTGYGI
                     YYVCRLSMNVIRKPIVEDGVFTETQLGIIGSCLFFVYAVGKLTNGFLADRSNVKRFMST
                     GLLCSALINLCLGFTNSFFAFVLLWGLNGWFQSMGAASGVVSLTRWYSSKERGTFYGFW
                     SASHNLGEALTFISIALLVSWMGWRYGMIGAGVIGLLGFLMMLAFMRDTPQSQGFLLDR
                     WGTSDAHSVSGKQTEEFNKAQKAVLKNPAIWILALSSAFMYISRYAVNSWGVFYLEAQK
                     GYSTLDASFIISISSVCGIVGTVFSGIISDKFFAGSRNVPALIFGLMNVSALCLFLLVP
                     GVHFWVDALAMVLFGLGIGVLICFLGGLMAVDIAPSNASGAALGVVGIASYIGAGLQDV
                     MSGILIEGQKTVQNGVEVYDFTYINWFWIGAALLSVVFALLVWNAGEKRSEIN"
     CDS             complement(10853..11773)
                     /locus_tag="ctg16_16"
                     /transl_table=11
                     /translation="MKKYIMIGILFAFPFCLSADEPVKAIYAKITNPDNKEITVVAHRA
                     DWRYAPENSLAAIESSIRLGADVVELDVQKTKDGQLILMHDKTLDRTTTGKGKVAEWTL
                     DSIRTLYLKNGAALKTKHRVPTLEEALWVAKGRVMVNLDKAYPIFDEIFPILEKTGTVD
                     QIIMKGSKPVADVKKDLGKYLDRIIYMPIIHLDKPGAMKQLDDFMTELHPVAFELLFVS
                     DTCQAPKQVKTKLKGKSKIWYNTLWDTMAGGHDDDKSLENPDEGYGYLIDTLGAAIIQT
                     DRTAYLLEYLQSRKKRSENGQDAYH"
ORIGIN
        1 tccaaaactt ccttatcaga agtgcttttc gttaaaagcg gtgcaaaggt acgaagatat
       61 tttaaacttg caagagtttt cactaaaaat ttaatctaat cttttcctaa ggatagcaat
      121 taataggtat tttatgttga aaagcataaa atagagcata tttatgctga ttatatgaaa
      181 aatgattgta actttgtgcg ctctaaagaa taggataact acaacctcta attttatcat
      241 tttatggaat taaacaagat ctttaaagac ggtctttgga gcagcgaaat caacgtcaga
      301 gatttcgtaa gtcataacat cactccgtat tacggagatg cttcattcct cgaaggacct
      361 acagaacgta ccaaagccgt atggaaccgc tgcctcgaag cactggcaga agaaagagaa
      421 aacaacggtg tccgctcatt agataatgtt accgtatcaa ccatcacttc ccacaaggcc
      481 ggatatatcg acaaggaaaa cgaactgatc gtcggcctgc agacagacga acttctgaaa
      541 cgtgccatca agcctttcgg aggtatcaac gtagtcagca aagcctgtca cgaaaacggc
      601 gtggaagtgg acgaccgcgt aaaagatatt ttcactcact accgcaagac gcacaacgac
      661 ggagtattcg acgtatatac ggaagaaatc cgttccttcc gttcgctggg attccttacc
      721 ggacttcccg acaattatgc acgcggacgc atcatcggtg actaccgccg tatggctctt
      781 tacggcatcg accgtctgat cgaagcaaag aaggaagatt tgcacaacct caccggtccg
      841 atgacagagg cccgcatccg cctgcgcgaa gaagtggcag aacagatcaa ggcactgaaa
      901 gacatgaaag tgatgggcga atactacggt ctcgacctga gccgtcccgc ttacacggca
      961 caagaagccg tacagtgggt atatatggct taccttgccg ccgtcaaaga acaagacggt
     1021 gccgctatgt cactgggtaa cgtttcttct ttcctcgata tctatctgga atatgaactg
     1081 agcaaaggaa ccatcaccga atcgttcgcg caagagctga tcgaccagtt tgtcatcaaa
     1141 ctgcgtatgg tccgccacct gcgtatgcaa tcatacaacg acatctttgc aggcgacccg
     1201 acctgggtaa ccgaatctct gggcggacgt ctcaacgacg gacgtaccaa agtgacaaag
     1261 acctccttcc gttttctgca gacattgtac aacctcggcc cttcaccgga accgaacctg
     1321 accgtactct ggagcccgga acttccggaa ggattcaaag aattctgtgc aaaggtttct
     1381 atcgacactt cttctatcca gtacgaaaac gacgacctga tgcgtgaagt acgtcagtcc
     1441 gacgactacg gaatcgcctg ctgcgtatca taccaggaaa taggcaagca gattcagttc
     1501 ttcggtgccc gttgcaacct ggccaaagcc ctgttgcttg ccatcaacgg cggacgttgc
     1561 gagaataccg gtacagtcat ggtgaagaac atccccgtac tgaccagtga cacgctgaag
     1621 ttcgaagaag taatggacaa ctacaaaaaa gtgctgaccg aaatcgcccg cgtatataac
     1681 gaagcgatga acatcatcca ctatatgcac gacaagtatt actacgagaa ggcccagatg
     1741 gctcttgtag atacgaaccc gcgcatcaac ctggcttacg gtgtagccgg actttccatc
     1801 gccctcgatt cactgtctgc catcaaatat gcgaaagtaa ctgcccgccg caacgatatc
     1861 ggcctgacag aaggtttcga catcgaagga gaattccctt gcttcggtaa cgacaacgac
     1921 aaggtagacc accttggcgt agacctggta tacttcttca gcgaagaatt gaagaaattg
     1981 ccagtttaca agaatgcccg tcctaccctc tccttgctga ctatcacttc caatgtgatg
     2041 tacggcaaaa agaccggtgc tactcccgac ggacgtgcca aaggtgttgc cttcgctccg
     2101 ggtgccaacc cgatgcacgg acgcgacaag aatggtgcga tcgcttctct gagctctgta
     2161 gcgaaacttc gttaccgtga ctcacaggac ggtatcagca acaccttctc tatcgttccg
     2221 aaatcactgg gtgctacgga cgaagaccgt atcgagaacc tcgtaacgat gatggacggt
     2281 tacttcacca aaggtgctca ccacctgaac gtaaacgtac tgaaccgtga tatgctgtac
     2341 gatgccatgg agcatccgga aaactatccg cagctgacta tccgcgtttc cggctatgcc
     2401 gtaaacttcg tgaagctgag ccgcgaacac caactggaag ttatcagccg tagcttccac
     2461 gaacgtatgt aatctattac tctatatgat gataaacgta cattcatacg aaagtatggg
     2521 aacattcgac gggccgggct tacggctcgt cgtttttctt caaggatgca acttccgctg
     2581 cctctattgc gccaatccgg atacgatagc aggaaaggga ggcacgccta ccccaccgga
     2641 agaaatcgtc cgcatggcaa tgagccagcg ccccttcttc gggaaacgag gaggaatcac
     2701 tttctccgga ggcgaaccga cgtttcaggc gaaaacactc gtcccgctgg tccgcgaact
     2761 gaaagaaaaa ggcatccatg tctgtctgga cagcaacgga ggactttgga acgaagacgt
     2821 agaagaatta ttcagactga ccgatcttgt gttattggat ataaaggaat tcaaccccaa
     2881 ccgccatcag acgctcaccg gaagaagcaa cgagcaaacc atccgcacgg ccgcctggct
     2941 ggaagaacag gagaaacctt tctggctacg ctacgtgcta gtgcccggat acagcgattt
     3001 tgaagaagac atacgcgcac tgggagaagc actcggaaaa tacaagatga tccaacgggt
     3061 ggaaatactg ccttaccata cactgggcgt acataagtac gaagcgatgg gacaggaata
     3121 caagatgaaa ggggtaaaag aaaatacccc cgaacagctt gaaaaagctg cggaggtatt
     3181 caaagagtat ttcactacgg tggtagttaa ttaatggaga attctccaat gacctcaaag
     3241 caagggcatt ctttaatccg ttcccaagga tctacgatcc cattatagtt ggtgtcggga
     3301 cttaaatccc gatgccctac tactttagct tccggataac gctgcaacaa ttcgtgtacc
     3361 aagcgatgta gcgcctcctt ctgacggggt gtacgcgtat ccgcagcttt tccattctca
     3421 tccagaccgc cctcataaca tacacctaag ctgatcgcat tatagccacg tgcatgagct
     3481 ccgaccgtat cttcatcccg catcggctca atctcgcccg acttgcgtat ataataatga
     3541 tacccccagc acgaaaagcc acgataacgg tgagccgtat ccacatcctt tgccgtaaag
     3601 tcgcaatcga cacgggtggc ggaacaatgg atcacaatca gactaatctt tctcatgttc
     3661 cttttccctt tccgtcgttt tcactttgca cacctcctta caagtagtat gatagcgcac
     3721 ttctctcacc accctgtccc gctttctctt tccgaagaaa ggaatcagat acatgatcac
     3781 atctaaaatc cgacttacta tttctttcat cttatcaaaa tattaatgga agttattcta
     3841 attcgttatt accttgaccc gtctgccaat tataccgtag ggtccggagc ctcttcatca
     3901 ccggagccat caccaccgga atccggattc ttgtcagggt cttctccccc gccatcgcct
     3961 gcacccgcct gcgccaccgc acgagtctgc acttgctgat aactcagaat cttcatcaac
     4021 tccgccagcg tcttaccggg gcggaaaata agatgcgccc ccttaatcat tgaaccggaa
     4081 aattccttga ccgatgccgc accttcactg ttgagtccta tctgcaaact gcccaaatcg
     4141 cccagtctcg caattcttcc tgccttcaac gcacgcttca cttcgtaaag aatacccgaa
     4201 atagccgcac gtacatccgt ttccgtacaa gtagaacgac tggtgatcgc ttcgcacaac
     4261 tcttcaaagt ccaactctcc cgacgcctgc gcctgtgcat aatactttgc cggttcgctc
     4321 ttttttgcag gattcttgcg cggcaccact gaataagata ctgtcattgc cataataaaa
     4381 taattttaaa gtttataata cataggatgc atccccttct tgttaacagc acaaagataa
     4441 ggatagccgg acaagccata ttccccaacg aagtttcttg attcccaacg aataaaaacg
     4501 aagtcaaacc tttgaataac aatgaatttt atgtaacttt atagcataaa acaagaagaa
     4561 aacatcatga attacaaaga agattctttc cttatccgca cctataccaa agcggaactg
     4621 gctcaccttt acaatcccca tgtctgcctc aaagttgctt tacaaatact tcgtcgttgg
     4681 attatttaca acctccctct cctgcacgaa ctcgaacagg aaggctaccg cgcacgcaac
     4741 cgtctccttt cgccgaaaca agtggcaact atcatacact ttttgggcga accgtagtaa
     4801 cttattgcca ttttatacaa agttccttta cacatttccg caaagaagtt cctttgcatc
     4861 gacaaacaat aatcaaaata aaaatgaaac atttcaccat atttcaaggt ttctactacg
     4921 caatagcaga gatgaccgaa gaagaaatag tgtccactat cggctgtttt acctaccggg
     4981 aaaaagtcga agaaatacgc cgcatctttg cagagcaagg agaaaaggct gccaatgaga
     5041 agaaaaaaga attgccggca atcgccttct ccgccagcta ccgaggaagg cgtaccaaag
     5101 tgaacctcgt caaatatctg ggacacatcg tgatagacat cgaccacctc agcaaagaag
     5161 aattggcacg catcctccct atcatcaaga gatgcgatta cacccgcatc gcctttatca
     5221 gccccaaagg gatgggcgtg aaaatcatag tacgcgcatg ccatccggat gagacattgc
     5281 ccgaaaccct tcaggaaata gaagacttcc atcatgcagc ttacaccaga ctcgtttctt
     5341 tttacaccga actctgtcag atagaaatcg acacctccgg tcaggatgtg gcacgcactt
     5401 gtctgttctc ttacgatccg gagatttatt tcaatccgaa cgctgacgct tttcttgtag
     5461 atcaacctca ggcatcctac aaggtttcaa atcgtaaaaa tctctccggc agtaaacaac
     5521 agactcctcc ggacggcccc ccgacgaatg aagacacagc gctcaacgcc cattccgcca
     5581 acgcttctct ggtgctgact ttaacctact atcacaacaa gtccgaaaaa tacatagtgg
     5641 gcaaccggaa caattatctg caccatctct catgtacctt caatcgctac ggcattccgc
     5701 aggaggaagc atccgccttt atcaaaagcc agtttacaga ctttccggcg gacgagacag
     5761 cctctttgat caatagcgcc tacgctcata ccgacgaatt taatacctgt aagctaaatg
     5821 gcacgcagaa acgaatatta cggatagagc aatatatcag cgagcactac gaaacacgct
     5881 acaacgaagt gctgcatatc atggaatatc gcagaaggca tcccgacacc gagaaaccgg
     5941 agcctttccg catcttggat gagatgatgg aaaacagtat ctggatagaa atcaacgaac
     6001 tgggatatgc ctgcactgtc aaaacaatcg aaaatctgat ttactccgat ttcagccagt
     6061 cgtatcatcc cattcgcgag tattttgaat tactgcccga atgggacgga accgactata
     6121 tccgtatcct ggcggatagt gtccagacga gtcatcagga gttttgggcg gaatgcctgg
     6181 aacgttatct ggtggcgatg tgcgcagcgg ctactcaaga gaatattgtc aatcacacgg
     6241 tacttctgct atgcagcgag atacagaaca taggaaagac tacctttatc aataatctcc
     6301 tgcctcccga actgcgtgct tatctctcta ccggactaat caattcgaac aataaagatg
     6361 atttagccaa aataacgcag gccatgctga tcaatctcga cgagtttgaa gggatgagcg
     6421 gtcgggaact gaatgcattc aaagatttgg taacgcgcaa agtgatcagt ttccgtctgc
     6481 cttatgcacg ccgttcgcaa aacttccctc atacggcctc ttttgcagga acctgcaatt
     6541 atcaggaagt gcttcacgac acgacaggca accggcgttt cctttgtttt catccttatt
     6601 ccatccaatt tattaccatc aattatgcgc agctctatgc tcagatcaaa tatctgctga
     6661 ataagccggg atatcaatac tggttcacgc aagcggacaa tgaacggctt gaagagaata
     6721 acgaggcttt catctttcat tcaccggaag aagaaatggt tcttacgcat atccgcaagc
     6781 cggaacgttt cgagaaggtt tattatctga ctgtcagtga gattgcggaa ctaatacgtg
     6841 agcgtaccgg ttatcagtat tccatcggat caaaaataca gttggggaag gtgatgacta
     6901 agcaccattt tgaatctaaa aaaggaaata acgggcgccg atatgccgta tttattatag
     6961 atatcgagca ggtaaaatca aacaggctgt atgaatagaa gcgggaaagc cttgtgaata
     7021 tagcaaaatg cagagtcatc ttgacagata ctctgcattt attgttttta caaaatcatt
     7081 gaaaattcga ttttacagcc taacgcattc attatacgat agaaagtaga tactttaggc
     7141 tctgtctgac cactttctac tcttgaaata taagaacggt cagagccgat acgccgggct
     7201 aattcagcct gagtgatttt agcctttttt cttgcgtcct cgataatctg tcctgtataa
     7261 aaggcgtagg ccttttcttc tgcctctgca cgctcgggag taccttcagc accaaatttg
     7321 gcatcaagga cagcatcata atctactatt tgatgattgt ttatctgcat aatattcctc
     7381 ctttatttta actgctttat caatttcatg accaggtgtt ttttgtgact tcttttgaaa
     7441 gccattgaac aacacaacaa tattaccatc atcaaatatg aaaaataccc ggtatatatt
     7501 gttattatat tctgtgcgaa gttcaaaaac tccatcccga ataaacttca caaatttagc
     7561 ggagagtctt tcttgtgttt tcaacaagag taatccgtat tgaatcttat cttgttcctt
     7621 ttcggttaaa gtctccatga aagcctcaaa gtaacctccg tatgtacgga tcttacgttt
     7681 cttttccata acgcaaatat aaggaatgtt gttcaactat acaacacatt tcctcgtttt
     7741 atattatttt tcatcatctt ccccccaaaa agtgagagga gtgagagagg aattgaaact
     7801 ttttctattt tatttcttta tttctacttt ctatatttct ctaaaaaaaa tacgaatgtt
     7861 agaaatcctc tctcactcct ctcacttttt accttttctt tctccaaaaa gacggcggaa
     7921 aatcggaaaa acacaaccgt cttttttcaa tttcccaccg cattttcaaa tcagcccacc
     7981 aattgaagca gacttcagga aatatttgtt atctttgatg tgcaaaagat caaaagaatc
     8041 agatatggac aacttgatgc gtaaacttcc tattggaata caaacctttg aagatatacg
     8101 aaggaagaat atcttattgt aaagatcgga gtggaattta gtgcagaaag ccggaactta
     8161 aatcgttggt taatcgaagt gataggaaag taaaatatga aaaaccgaag gattaagata
     8221 tccttcggtt ttttcgacta tatacccatg attggtttta cgatttcaat cttcaatcct
     8281 aatgcattaa taattcggta gaatgttcct acacttggat ttatagctcc gctttcaata
     8341 cgtgagatat acgatttagt tgcattgatt ctctttgcta attcagactg agttactttt
     8401 gcttcccgtc gtgcatccaa cagtatttga ccagtataaa aagcgtatgc ctcttcatcg
     8461 aacttttcac gttccggagt cccaggtgct ccgaactcct tatcaagttc tgcgctgata
     8521 tcagtcagca tgttgttttt tgtactcata atattcctcc tttattttta atgccttatc
     8581 tatttcagat gatggggttt tctgtgtttt cttatggaag ccattaaata aaacaactat
     8641 ttgcccttca tcaaaaatga aaaagatacg gtaaatgttt ccgttatatg atatacgtag
     8701 ttcatataga ccatcacgta taacctttat aaatttgata ggcaaacggt cttctgttcc
     8761 aagcaatgaa agcacatatt tcactttttg aatttccttt tctgtcagag tggcaagaaa
     8821 atccttgtag tattgaccgt atgctattac ttttcttctc attgtgcaaa tataataaaa
     8881 gtttcaatat catacaactt tcaaagtcga atttatactg ctaacgggct taaattccct
     8941 ctcaggtact cattttattc gaatttccct tccgaataat ctgaaaactc cccggcacgt
     9001 tctttcttct catacgaaac caacgtttcg atactgagcg ctttcccgtt cttagggctt
     9061 atgacatcta tcacacttga caaggaccgg aacgtctgtt cgcaattcgc gtctccatta
     9121 tacgtcaacc tcccccggtc aatggcacct agaataacag aaacataccg tttcggatct
     9181 ccccgatatt cgataacagt gggcgtcatt tgttcttctt cccgaatcag ttggacgaca
     9241 attctttttt ttggtcaatc agctccaaca gttttttact atgcacactg atttgtgcat
     9301 ctacttcacg aagttcattc ttcaatgaac aaaacaattc atcactcaat gaattttcca
     9361 taaaaacgat ttttattaat tataaaaaag ccattccgga aagcacagct attgcctgct
     9421 tcccgaaatg gtgactaata ccttcaaaaa caatgactct atttttactt taatgtactc
     9481 aatttatttc acttcttttc tctcctgcat tccaaaccaa caaagcaaac actactgaaa
     9541 gcaaggctgc accaatccaa aaccaattga tatatgtaaa atcgtaaact tctactccat
     9601 tttgcaccgt cttctgacct tcgatcagaa tgccactcat cacatcctgc aaaccggctc
     9661 ctatataact cgctataccg acaactccca aagcggctcc cgaagcattg ctgggagcaa
     9721 tatcgacagc catcagtcct cctaaaaaac aaatcagcac tccaatgccc aaaccgaaga
     9781 gcaccatcgc caaagcatcc acccaaaaat gtacccccgg aaccaataga aacaaacaaa
     9841 gagcagacac attcattaat ccgaatatca aagccggaac attacgactg ccagcaaaaa
     9901 acttatctga aataatacct gagaaaaccg tacctacaat tccgcataca gaactgatag
     9961 atataataaa actagcatcc aaagtagaat aacctttttg cgcttccaga tagaaaacac
    10021 cccagctatt gactgcataa cggctgatat acataaaagc actggataat gcaagaatcc
    10081 aaatagcagg attcttcaaa actgctttct gagctttatt gaattcctcg gtttgcttac
    10141 cggaaacgga atgagcatct gacgtccccc accgatctag caaaaagccc tgactttgag
    10201 gcgtatcacg cataaaagca agcatcatca gaaaaccaag caaaccaatc actcccgcac
    10261 cgatcatccc ataacgccat cccatccaac tgaccagcaa agcgatggat ataaaagtca
    10321 gagcttcacc caaattgtgg ctggccgacc aaaagccata aaaagtacct cgctctttac
    10381 tactatacca acgagtcagc gacacaactc ctgatgctgc ccccatcgac tgaaaccaac
    10441 cattcaaccc ccaaaggaga acaaaagcaa agaaggaatt cgtgaatccc agacataagt
    10501 tgatcagagc agaacacaat aatccggtag acataaaacg ctttacattg ctacggtcag
    10561 caagaaagcc attggtcagc ttaccgacgg catatacgaa aaaaaggcag gaaccgataa
    10621 tccccagttg ggtttcggta aaaactccgt cttctacaat cggtttacgg attacattca
    10681 tactcaaacg acaaacataa taaatgccat atccggtagt ggcagacaga aaggtagccc
    10741 aacgaatacg cttgaaacgg acagagcgtt ccggatcagt ctctcccccg gacaccggag
    10801 gagagatttt ataaaaatcc aatagtttaa atcccataaa gaagtctata ttttaatgat
    10861 acgcatcttg gccgttttca ctacgcttct tacgcgattg caaatattcc agcagatagg
    10921 cagtacggtc tgtctgaatg atggccgctc cgagtgtatc gatcagataa ccatatcctt
    10981 cgtccggatt ctccaacgat ttatcatcat catgtccgcc agccatcgta tcccacaacg
    11041 tattatacca gattttactt tttcctttca acttcgtttt tacttgcttg ggggcctggc
    11101 aggtatccga tacaaataga agttcaaaag ctacgggatg cagctccgtc ataaaatcat
    11161 ccagttgctt cattgctccc ggcttatcca aatgaatgat aggcatataa atgatacggt
    11221 ccagatattt acctaagtct ttctttacgt ctgccacagg cttggaacct ttcatgataa
    11281 tctgatccac tgttcccgtc ttttcgagga tgggaaaaat ctcgtcaaat atcggatatg
    11341 ctttatccag attgaccatc acacgacctt tggcaaccca taaagcctct tccaaagtag
    11401 gtacacgatg cttggttttg agtgccgctc catttttcag atagagtgtc cggatagaat
    11461 ccaatgtcca ttcggctacc tttccttttc cggtagtcgt tcggtccagc gttttgtcat
    11521 gcatcaggat caattgaccg tctttggttt tctgaacatc cagctccact acgtcagctc
    11581 ccagacgaat ggaactttca atagcggcaa gtgaattttc gggtgcgtaa cgccagtctg
    11641 cccgatgagc tacaaccgtg atttctttat tgtcagggtt cgttatcttc gcataaatgg
    11701 ctttcaccgg ttcgtctgcc gacaggcaga aaggaaatgc gaataagatt cctatcatta
    11761 tatatttctt catatctata tgtactatta tctgtatcct ttagacttta aatatttggc
    11821 agctacttca gcatagtctg tttgcacaat gttgatgcgt ttgttaatca ttcccaccaa
    11881 accggagtag ttttccgaca acatattggt atcattcgct ccgacaatgt tggagaaaag
    11941 aagccagcct ttatctttaa tctcattaac catcgttcca cccatagcat ctgacgtaga
    12001 cagctgcatc atttgtacat tatcagtgta ggatgaggag aagtatgtga tgtcatcggt
    12061 agctttcgcc atcgggtgca acagcaaact actgttggct gccttcaaat caaatgcata
    12121 attgcgattg ttggatacat acagcaaagt ggaaccttcc atatccaatt ttttaagcaa
    12181 tgcgacgatc gtatttaccg caacattctt gttgacaata tccagattat aataaacttt
    12241 tccttttcct ttcttcatcg cttcctccaa agtcgggatt cgttcgccag ttatattgcc
    12301 ggatgcatct ttcagataaa attgttgtaa ttgctgataa gtaaagtctc ccaccgcacc
    12361 gctaccgttt gttgtccggt cgatggtgtt gtcgtgcatc aataccaaca caccgtcaga
    12421 ggtcggccgt gcatccagct cgatcatctc aactcctgct ttgaccgagt gttctatcgc
    12481 aggtaacgag ttttcgggaa tcccctcttt catccctttt tgggtatttc cacgatgcgc
    12541 gcagagccac actttataag aggtgctttc aaacagactc tttaaatctg ctttcaaatt
    12601 ccccgtcaca ggcaactgtc ctccttcttc tccaccggga ttctctccat tccctcccga
    12661 ttgggctccg gagtgacgtc tgtccttccc tttcatcggc caggcagagg ttgcggcccc
    12721 ggtaattccc tcatcttcca aagctaccaa cacgctcttt gtagggtcca ccgtattggt
    12781 gactccgata taaatcgctc catccggtcc gatggtaggc gaactccaga ttttaccgat
    12841 tcccgcttcc caatctcctt ttaaaggaga gtcactttca ctaatcaacg cagcaaggtc
    12901 ttttttcaga atcaattgtt catccgattc ttccggttta atgatataat aattgccgga
    12961 ctgggtgccg aaatgtatgt ttcctgcttg atcaattgcc gcacaaccgc ttacatcttc
    13021 cgcaatgccg taatgccatt ggatagctcc tcccggagac aaagagatga ttcctccggt
    13081 tgcttccccc ggagcacgtt tcactgtaac gataatgctt ccgtcgagtc ctatcacaac
    13141 accgccttga tccagcgtgc cgacattgcc caaaggagta cgccacttct ccactccatc
    13201 acttcctata gcaa
//
