LOCUS       c00513_gnlPro..        15328 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCIHHKOB_513.
ACCESSION   c00513_gnlPro..
VERSION     c00513_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 19:15:59
            Original ID  :: gnl|Prokka|LCIHHKOB_513
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15328
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15328
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1266:5328]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1267..5328
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15328
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15328
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(3..485)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg513_1"
                     /sec_met_domain="IlvN (E-value: 9e-38, bitscore: 120.9,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYEKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLE"
     CDS             complement(535..1116)
                     /locus_tag="ctg513_2"
                     /transl_table=11
                     /translation="MSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCF
                     ELADENGKTFGFARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKA
                     EGIPYSIKYSDLDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLT
                     LHKAESAPDKQDMAICHEGKAICRAAVTWR"
     CDS             complement(1267..1821)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg513_3"
                     /sec_met_domain="ALS_ss_C (E-value: 5e-17, bitscore: 53.4,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLQEKQQ"
     CDS             complement(1837..3318)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg513_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.5e-50, bitscore:
                     160.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LVTSGPGATNTITGIADALMDSTPMVVIAGQVPSPLLGTDAFQEV
                     DVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLDLAKDAQVGLVDYEYK
                     KVDYVRSYQPEPDIKKDRIKAAADLINEAKKPFCLVGQGVLLGGAEEELRAFLQKNDIP
                     AGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIGMRFDDRVTGDLKTYA
                     KQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERKRPEWNAEFDRDEKEE
                     YDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQMMGVRYFKYKQTRSVV
                     TSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELGTIMQEKLNVKIIILN
                     NNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIASRAVEKREELDDAIAEMLNH
                     DGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             complement(3574..5328)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg513_5"
                     /sec_met_domain="ILVD_EDD (E-value: 1.3e-216, bitscore:
                     711.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEEQFGKPIIAIVNSFTQFVPGHTHLHEIGQLVKAEIEKQGCFA
                     AEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGML
                     MASMRLNIPTVFVSGGPMEAGELDGRHLDLIDAMIESADTSVSDERIEQVERHACPGCG
                     CCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIVENAYKYYRDGDD
                     SVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHMEDIDMLSRKTPCL
                     CKVAPNTHTYHVQDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDKYAVTSPN
                     VTEEAIRKYKSAPAHRFSIQMGSQESYYKELDTDRAEGCIRDVEHAYSKDGGLAVLRGN
                     IALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITYEGPKGGP
                     GMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLVRDGDI
                     IEINIPERSINVRLSDEELAERRKAEEARGKKAFTPPMRQREVSKALRAYGKMVSSADK
                     GGVRIVED"
     CDS             complement(5606..5695)
                     /locus_tag="ctg513_6"
                     /transl_table=11
                     /translation="MKNFLLNPLRISIIVLHLQRQTNKDNKKR"
     CDS             complement(5970..6212)
                     /locus_tag="ctg513_7"
                     /transl_table=11
                     /translation="MKCCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIFIRML
                     TKFSPILDEISSLCSSENFLMFFLEHYYEFFQGYL"
     CDS             6296..7471
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg513_8"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.1e-43, bitscore:
                     139.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHYNFDEVIERHGTSCVKFDRLKEMFGDENLIPLWVADMDFRTP
                     DFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHYKHNWKIQREWISYIPGIVKGIAFA
                     IQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDGVYEMDFDHLESIIDDKC
                     KVLILCNPHNPGGIVWKKETLVRLADICAKHNILVISDEIHAEMAYPQYTHYPFASVSD
                     TAASCSVTFMAPSKTFNIAGIVTSYAIVPNDRIREEFYSFLEAGEFGDGTIFAYTATTA
                     AYTYGAEWLQQMRMYIMENVRFVEEFMKQHLPKIKVYQPQASFLVWLDCRELKLSQDEL
                     VHLFKDKAGLALNDGSIFGPGGEGHMRLNIGCPRSVLDKAMNALKKAVDKK"
     CDS             7520..8095
                     /locus_tag="ctg513_9"
                     /transl_table=11
                     /translation="MKITANKYVAVTYDLNVGEGEERELMEKATVEAPLKFIYGTGMML
                     PAFEKALNGLEVGGTFNFSIEPAEAYGEYNEEHVLDLPKNIFEVDGKFDAEMIKEGNTV
                     PMMDSNGNRMNGSVLEVKDDIVVMDFNHPLAGETLHFSGEVIDVHEPTAEEIAAFSAPA
                     GGCSCGCDDCGSDCGDNHEGGCGCGGCH"
     CDS             complement(8298..8510)
                     /locus_tag="ctg513_10"
                     /transl_table=11
                     /translation="MGRTVNRFHIVIVRGMLVFVPDDETYRRTGCLSLVDTRKKLYLII
                     LFTGGRDTGLSRFTTVQLLLDECRI"
     CDS             8715..9275
                     /locus_tag="ctg513_11"
                     /transl_table=11
                     /translation="LTEKSDVRCPDPKTASEMETLIAEVKSKGDTIGGVITCVAKGVPV
                     GLGEPVFGKLHAALGHAMLTINAVKGFEYGDGFNAAFFRGSERNDRFFNDNGHINTRTN
                     NSGGIQGGISNGQDIYFRVAFKSVATILMEQETVNMEGEDTILKARGRHDPCVLPRAVP
                     IVESMTAMTLLDYLLIQKTRENF"
     CDS             9288..9608
                     /locus_tag="ctg513_12"
                     /transl_table=11
                     /translation="MAWILLIIAGLFEIGWPLGFKLASMHSKYFIWFIGLSILSMGLSG
                     YFLYLAQKSIPIGTAYVIWTGIGAIGTVLLGILFFHDSANIFRLLFLSLILIGIVGLKL
                     VH"
     CDS             complement(9716..10189)
                     /locus_tag="ctg513_13"
                     /transl_table=11
                     /translation="MKIGLIVIGKTDAGYFVEAINEYKNRLTHYIPFEMEVIPDIKNVK
                     NLSEAQQKEKEGELILKALQPGDYLVLLDEKGKEFTSMQFSTYLEKKMHTVPKRLVFVV
                     GGPYGFSEAVYKAASEKISLSKMTFSHQMIRLIFIEQIYRAMTILNNEPYHHE"
     CDS             10398..10649
                     /locus_tag="ctg513_14"
                     /transl_table=11
                     /translation="MDKVVDVALPGSSKKCNGSEAVSMLSSFFSSNKPSGFSVVHHADK
                     KESGFLVGKLPTSSGEYRVNITYRAEGNTAIIQSIRIE"
     CDS             10653..11492
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg513_15"
                     /sec_met_domain="QRPTase_C (E-value: 7.3e-63, bitscore:
                     202.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="QRPTase_N (E-value: 1.8e-27, bitscore:
                     86.7, seeds: 125, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGV
                     LAGVEMAKRIFHDFDPELKMTVFIQDGAEVKKGDIAFVVEGKIQSLLQTERLMLNVMQR
                     MSGIATTTRKYAKALEGTKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMILLK
                     DNHVDFAGGIEQAITRAQNYLKEKGKSLKIEIEVRNFDELEQAMKVGGIDRIMLDNFNI
                     ENTKEAVRRINGRFEVESSGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKAC"
     CDS             complement(11779..11967)
                     /locus_tag="ctg513_16"
                     /transl_table=11
                     /translation="LGFASFTDDDVGQFLLSLTDASRYLCQISSPFYGGRSFPLILRFL
                     CGIDRFSGIFNRPVGHQ"
     CDS             12673..12990
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg513_17"
                     /sec_met_domain="Aldedh (E-value: 4e-35, bitscore: 112.5,
                     seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIIQEETFGPVLPVVEYSDINDAIAWANDCEYGLTSSVYTQNLD
                     NAFKVMRSLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLEEYLQTQVVYLETK
                     E"
     CDS             complement(13036..14601)
                     /locus_tag="ctg513_18"
                     /transl_table=11
                     /translation="LNPTADGEACNACESCRAFNEQRSYNIHELDAASNNSVDDIRTLI
                     DQVRIPPPIGKYKVFIIDEVHMLTTAAFNAFLKTLEEPPHHALFILATTEKHKVLPTIL
                     SRCQIYDFSRISIADMVEHLQYVSSQEGVTAEPEALNVIAQKADGGMRDALSIFDQVVS
                     FTNGNITYQAVIDNLNVLDYEYYFRLTDAILSGNVRASLLILNEILGKGFDGQNIITGL
                     AGHFRDLLVCRDESTLVLFEVGASIRERYKEMAKHCPDQLLFKAIELANTCDLNYRASR
                     NKRLLLELTLIQLCQLTQVAADDKKKALIEPIAGTNPSSQAVNSGKPQQPPQAPSVTAA
                     AGAPQVMSTHMPSSVPAPPPSTAPNSVRRTARPMGISMKEIGVEKPKQQTVQQATTNVK
                     EVVTPFDNDSLVREWDNYAATIDKKVYLKNTMINCKPTLQENYYFEVAVHNPGQQEELI
                     NNAIHILPFLRQHLNNSRIQMRVRIVEGNEKHLAYTSTEKLELLMKINPTLGRLRDEFN
                     LTLD"
     CDS             14866..15171
                     /locus_tag="ctg513_19"
                     /transl_table=11
                     /translation="MSRIKEFYIKYLSWINAYWLVTIVFLIVTFTVGDSSLYKRYTYDE
                     KIRGLEKEIKHYQKEIEINSKKLNDLHTDKEGLERFAREEYFMKRSNEDVFIIKDK"
ORIGIN
        1 ccctcaagga acatggaacg caaagacgta ccagacccct tcggagcgac catgatcacg
       61 tcaatatccg caggaggaac aacacctgta cgatcgttcc aagtgatcgc gaagccatga
      121 gagaaataca gggccttgcc agctgtcaaa taaggcttca tcgtaggcca tacagacatt
      181 acggcagcgt cggacaataa gcacatgatg atcgtggcct tgtcgcaagc ctcctcgata
      241 ccgaacagag tctcacccgg aacccatccg tcctcaaccg ctttctcgta agtcttacct
      301 tggcgctgac caacgattac gttgaagcca ttgtcacgaa ggttcaatga ctgtcccggt
      361 ccctgtacgc catagccgat aacagcgatt gtctcatctt ttaatatctc tcttgccttt
      421 tccaacggaa attcctcgcg ggtcattaca ttctctacaa caccgccaaa attcatttgt
      481 gccattttct ttttaactat taatgtttaa aaacctattt atgtatctct tttattatct
      541 ccaagtaacc gccgcacgac agatcgcctt tccctcatgg caaatagcca tgtcttgctt
      601 atcgggagcg gactccgcct tatgaagcgt aagcggcata ccttgtttgc cctcggattg
      661 gtaggcgatc tccagacggc cgatctcacg ggtcttgaac tggtcgatat cgaacaaatc
      721 cagcagatgc tcgatatact tcacgctatt gaagtgaccg ttgatatcca agtcgctgta
      781 tttgatcgaa tacgggattc cctccgcctt attctccgcc ggcatgatct tgcccggctt
      841 ctcgatcggg cacggacgct cgtcgatata tttgcccaat gcctctatat ccaataaggt
      901 aggacggcgg gtctccacgt cgatagccgc ccaaatagaa cgggcgaatc caaaggtttt
      961 cccattctca tccgccagct cgaaacaacg actggtgaag aggcgtccga cctcatcgat
     1021 ccaagtgtat agattaatct tatcgaaggc ggtaggatat tccttcatct cgatagccag
     1081 acgggacaac acccaagccg tatgacgctc cgacatatca ttgaaaccga acccacgctc
     1141 tccggcatgg ctggaagcgg cgtgaatcaa atagttacca atcataggga gcgttacacg
     1201 tcccctaaaa tccatcaaat atggctccgc cacgaaatga aataatccta ctttctccat
     1261 atcttattat tgttgctttt cctgtaactt tcgctccata tcggccaaca tatcgctcaa
     1321 gcgctccacc ttgctcttcg tgatagccac acgtccggag cggatgaatt gcaggacacc
     1381 gatcgtctcg ctcaactcat tgaacaaggc ctgtgtctcg tcatagtggc cactcttctc
     1441 caataccacg caggtctcgt tcatctccaa gatacgggcg ttgtatttac ggatcaatcc
     1501 ctccacggtt cccatcttga tgaaaagctc ggtacttagc ttataaagag cgatctcttg
     1561 ataaaccaga tcctcatccg tattataata agccttcaag atatccacac gtttatcgat
     1621 ctgtttcacc accttatcga tcatatcctc atcggcgaat gtcgtgatcg taaacttatg
     1681 gatgcccttg atagcggacg gagagacgga cagagtctcg atgttcagct gtcggcgtgt
     1741 aaagataatc gttatctggt tcaaaagacc tacgatattc tctgaaaaga taataacggt
     1801 atataatttc tttgttgtca tagcttcatc tcctccttat ttctcgtctc ccataatcat
     1861 gtttgtcacg cttcccccgg caggaaccat cggatacacc attccgcaag tctccacgtt
     1921 agcgaccaac acgtaagcgc cgtcgtggtt tagcatctcg gcgatagcgt cgtccaattc
     1981 ctcccgcttt tcaacggcac ggctggcgat accataggct ttagcgatcg ccacgaaatc
     2041 cggattctcc atgatggtgt ttgaataacg ctcgtggaag aacaattctt gccactgacg
     2101 taccatacct aagaagttat tattaagaat aataatcttc acgttcagtt tctcctgcat
     2161 gatggtaccc aattcctgaa tcgtcatctg cataccccca tcaccggtaa agaagcagac
     2221 cgtacggtct ggagccccga acttagcgcc catagcggcc ggcagaccaa atcccatcgt
     2281 acctaaacca ccggaagtca ccacgctacg ggtttgttta tatttgaaat agcggacacc
     2341 catcatctgg ttctgcccaa cgtcggtcac caatacagcg tcgttaccgg tcgcctcgga
     2401 aaccttacgg actacctcgc ccattttcag ttggccctcg gtcggataca attccttctc
     2461 gattacctta tcgtattcct ctttctcgtc ccgatcgaac tcggcattcc attccggacg
     2521 tttacgttct tccaacaacg ccgtgatcat cggtatcgtg tgcttggcat tacccagcac
     2581 ctttacatct acggggacgt tcttaccgat ttccgagttg tcgatatcca gatggataat
     2641 cttggcttgc ttagcgtatg tctttaaatc gccagtcaca cggtcgtcga aacgcatacc
     2701 gatagcgatc aatacatcac actcattcgt tttccggttc ggccctacgt ttccatgcat
     2761 accgagcatt cccttgttca atgggaaatc ggttggcaac gcagataagc ccaataccgt
     2821 agatccggca ggtatatcat tcttttggag aaacgctctc aattcctctt ccgcaccgcc
     2881 taacaatact ccctgcccga ccagacagaa gggtttcttc gcctcattga ttaaatcggc
     2941 ggcggccttg atacgatcct ttttgatatc cggctccggc tgataactac gtacgtaatc
     3001 taccttctta tattcatagt ccaccagccc tacttgcgcg tccttcgcta aatccagcac
     3061 aactggaccc ggacggcctg tagaagcgat ataaaaagca cgagaaacag cccatgcgat
     3121 ctcctccggc ttgcggattt gataagccca tttcgtgatc ggttgcgtga tgccaatcac
     3181 gtcgacttcc tgaaaagcat cggttcccaa caacggcgag ggtacttgac cggcgattac
     3241 gaccattggc gtactatcca tcagcgcgtc agcgataccc gtgatggtat tcgtagcgcc
     3301 cgggccggaa gtaaccaacg tcactcctac cttgccggat acacgagcat agccttgagc
     3361 cgcatgggta gcgccttgct cgtggcgcac caatacatgc ctcaactggt ccctataatc
     3421 atataaactg tcgtaaatag gtatcgcctg tccgccggga taaccgaaga tagtatctac
     3481 tccttcagca atcaacgctt tcagcaaagc ttccgaaccg gttatctttt gtttctccat
     3541 aagaaataac gtgtttaatg tatattattg gctttaatct tcaacaatcc ttacacctcc
     3601 cttatcggcg gagctaacca tcttcccgta cgctctcaac gctttcgata cctcacgctg
     3661 acgcatcggc ggcgtaaagg ctttctttcc acgcgcctct tccgctttac ggcgctcggc
     3721 caactcctcg tcgctcagcc gcacgttgat ggaacgttcc gggatattga tctcgatgat
     3781 atccccgtct ctcaccagtc cgatagcgcc accggaagcg gcctcaggag agatatgccc
     3841 gatagaaaga ccggacgtac cgccactgaa acgaccatcc gtgatcaagg cgcactcctt
     3901 acctaagtga cggctcttta tataagaggt aggatataac atctcttgca ttcccggccc
     3961 tcctttcgga ccctcatacg tgatgacgac cacatcgcct gaaacgacct tgcctcctaa
     4021 aatgccctcg caagcggcat cctgtgaatc gaagactttc gccgggccgg agaatttcca
     4081 aatactctca tccacgccgg cggtttttac gacacatccg tccaaggcga tattccctct
     4141 caaaacagcc aagccgccat ccttggaata agcgtgctcc acgtcacgga tacaaccttc
     4201 ggcacgatcc gtatctaatt ccttataata agattcttgg gaacccatct ggatactgaa
     4261 ccgatgagcg ggagcgctct tgtatttacg gatcgcctcc tccgttacgt tcggggaagt
     4321 gacggcgtat ttatcaacag cctcggccaa ggtcaggccg tccgcacgtc tcgtgctgcc
     4381 atccacaagc ccggctttca tcaactcgtt catgataccg aggattccac cggcacggtt
     4441 tacgtcttgt acatgataag tgtgcgtatt cggggctacc ttacacaggc aaggtgtctt
     4501 gcgggataac atatcgatat cctccatatg aaaatcggcg ccggcttctt gtgccacggc
     4561 caataagtga agcaccgtat tggtagaccc ccccatggcg atatccagcg acatggcgtt
     4621 caagaaagcc tgacgggtag cgatgttgcg aggtaacacg gaatcatccc cgtcacgata
     4681 gtatttgtaa gcgttctcaa cgatttgctt agccgcatca cggaaaagtt ggatacggtt
     4741 cttatgggta gccacgatcg tcccgttccc cggaagcgcc agaccgatcg cctcgttcaa
     4801 gcagttcata gagttagcgg taaacatacc ggaacaacaa ccgcaacccg gacacgcatg
     4861 gcgttccacc tgctcgatac gctcatcgct taccgatgta tcggcggact caatcatcgc
     4921 gtcgatcaaa tccagatggc ggccatccag ctcacctgcc tccatcgggc caccggacac
     4981 gaacaccgtc gggatattta atcgcatgga agccataagc atacccggcg tgatcttatc
     5041 gcaattgctg atgcaaacca tagcgtccgc cttatgggca tttaccatat attccacgct
     5101 gtccgcgata atgtcgcgtg aaggaagcga gtaaagcatc ccatcgtgcc ccatagcgat
     5161 accgtcatcg atagcgatcg tattaaattc agcggcgaaa caaccttgtt tctcgatctc
     5221 ggccttgacc agttgcccga tctcatgcaa atgcgtatgc cccggcacga actgggtaaa
     5281 tgaatttacg atagcgataa taggcttgcc gaactgttcc tctttcatcc cgttggcacg
     5341 ccatagcgca cgggctccgg ccatcctacg accttcggtg ctaaatgagc ttcttaacgg
     5401 attcttcatc tctttcctat tttttgttcg tagagcgctt tatccacgcc tctaccttga
     5461 tttatttata ataaaaaagc ctttccctat atggagaaag gcttaagaaa tatctctacg
     5521 acttcacaac ttcttacaca cctttctcct tacctactaa tgactagaag gaccaccacg
     5581 agaataatat gcaatacgtt gttcatcatc ttttcttatt gtctttgttt gtttgacgct
     5641 gcaaatgtag aacaataatt gatatgcgca aaggatttaa aagaaaattc ttcatttttc
     5701 tttcaattct caagcaaata ccattttagg attgcatttt aacaggagca agagtgtatt
     5761 acttaggaat cggaaggtat agaagggaaa aaacttcgat ttccaaacag aaacagtaaa
     5821 aagacaaatg ctatctaaaa cagattccag ataacatttt tatcagataa cacgacttac
     5881 gataacacgt atctcataag aaaatcctat tctagcgata aaaaagatac atataaactc
     5941 taaatcacat atttattaac acttgtagac tataaatagc cttgaaaaaa ttcataatag
     6001 tgttctagaa aaaacataag aaagttttct gaagaacata aggaagaaat ttcatctagt
     6061 atcggactaa attttgttaa cattcgaatg aaaatcacct nnnnnnnnnn nnnnnnnnnn
     6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6181 nnnnnnnnnn nnnnnnnnnn acagcatttc atattttgat ttggataaac aataaatata
     6241 ataatttgta tctttgaccc caatagcaat taagaaactg atcgttaata aaaatatgaa
     6301 acactacaac ttcgacgaag ttatcgaacg gcatgggacg agttgcgtga aattcgaccg
     6361 tttgaaagag atgttcggtg acgagaatct gataccacta tgggtggcgg atatggattt
     6421 ccgcacaccg gactttattg tagaggccct gaagaaacgt tgtgagcacg agatattcgg
     6481 ctatacattc ggctccgacg agtattacga gagtatcatc aattgggtac actacaaaca
     6541 taactggaaa atacaacggg aatggatcag ctatatcccg ggaatcgtaa agggaatcgc
     6601 tttcgctatc caatgcttta cgcaaaaagg agataaggtc atcatccagc cccctgttta
     6661 tcatccgttc cgcatcgttc cggaaaaaat gaagcgtgag gtcgtttata atccgctaaa
     6721 gatggtagat ggtgtttatg agatggattt cgatcatctt gaatctatta tagatgataa
     6781 atgcaaggta ttgatcctct gcaaccctca caatccgggt gggatcgtct ggaaaaagga
     6841 aaccttggtc cgcttggccg atatttgcgc caagcacaat attttggtta tctccgatga
     6901 gattcatgcg gaaatggcct atcctcagta cacgcattac ccgttcgcct ccgtatcgga
     6961 taccgccgct tcctgcagcg tgactttcat ggcaccgagc aagacgttca atatcgccgg
     7021 tatcgtgact tcctacgcaa tcgtacccaa tgatcgcatc cgggaagaat tttactcttt
     7081 ccttgaggcc ggagagtttg gcgatggcac gatcttcgct tatacagcga cgaccgccgc
     7141 ttatacctat ggcgccgaat ggttgcaaca aatgcgaatg tatatcatgg agaatgtacg
     7201 tttcgtggaa gagtttatga aacagcatct ccccaagata aaagtctacc aaccccaagc
     7261 ctccttcctc gtttggttgg attgcaggga actgaaatta agtcaagatg aactcgtaca
     7321 cctgttcaaa gacaaagccg gactagcgct gaacgacgga agtatcttcg gccccggggg
     7381 agaaggccat atgcgtttga acattggctg cccccgctct gttttagata aagcgatgaa
     7441 cgctcttaaa aaggcggtgg ataagaaata aaatcgtatc tttgcgagca tttctataca
     7501 tatttaaaat acaagacaaa tgaaaattac agcaaacaaa tacgttgcgg ttacatacga
     7561 cctgaacgtt ggcgaaggtg aagaacgtga gttaatggaa aaagcgacgg tcgaggctcc
     7621 tttgaaattc atctacggaa caggcatgat gcttccggca ttcgagaaag ccttgaacgg
     7681 gctggaagta ggtggcacgt tcaacttctc catcgagcca gccgaggctt atggcgaata
     7741 taacgaggag cacgtattgg atcttccgaa gaatatcttc gaggtagacg gtaaattcga
     7801 cgccgagatg atcaaggaag gtaataccgt accgatgatg gattctaatg gcaaccgtat
     7861 gaacggctcc gtattggaag tgaaggatga tatcgtggta atggacttca accatccgtt
     7921 ggctggcgag actttgcatt tcagcggcga ggtaatcgac gtacacgaac cgacagcgga
     7981 agagatcgct gccttctccg ctcccgcagg tggatgcagt tgcggttgcg acgattgcgg
     8041 tagcgattgt ggcgataacc acgagggtgg ctgcggttgt ggtggatgcc actaaataaa
     8101 gggaaattga gaattgaaaa ttgaaaatta ggagaagtgc ctaatcatcg gcttttgatt
     8161 ctcaattttc agttttcaat tttcaattag acaaaacggt gaatactttt ggtaatattt
     8221 atagattaac atcgttcggc gaatcgcacg gccccggtat cggcggcgtg atcgacggat
     8281 gcccagccgg gatcgaatta gatacggcat tcatccagca agagctgaac cgtcgtaaac
     8341 cgggacaatc ccgtatcacg accccccgta aagaggatga tgaggtacag tttctttctg
     8401 gtatctacga gggaaagaca accggtacgc cgataggttt catcatctgg aacaaaaacc
     8461 aacattcctc tgactatgac aatatgaaaa cggtttaccg tccttcccat gctgattata
     8521 cctatcaaac gaaatatgga atccgtgatc cccgtggagg tggacgttcg tccgcccggg
     8581 aaacgatcgc tcgttgcgtg gctggggcta ttgctaaact cgcccttaag caatacggca
     8641 tacagattca agcttatacc tcgcaggtcg gcccgatcaa attagcgggt agttaccaag
     8701 attatgattt aagcttgacg gaaaagagcg atgtacgttg cccggacccg aagaccgcct
     8761 cagagatgga aaccttgatc gctgaggtca aatcaaaagg agatacgatc ggcggtgtta
     8821 ttacctgtgt ggcgaaaggg gttcccgtcg gattgggaga gcctgtgttc ggcaagttac
     8881 atgccgcgtt gggacatgcg atgcttacga tcaacgccgt gaaaggcttc gagtatggag
     8941 acggattcaa cgccgccttc ttccgcggat cggaaaggaa cgatcgcttt ttcaatgata
     9001 acgggcatat caatactcgt accaataatt ccggcggtat ccaaggaggg atatccaacg
     9061 gacaagatat ttatttccgg gtagccttta aatcggtcgc tacgatcttg atggaacaag
     9121 aaacggttaa tatggaggga gaggatacga tattaaaggc acgcggacgt catgatccat
     9181 gcgtattgcc tcgtgcggta cctatcgtcg agtctatgac cgccatgact ttattggatt
     9241 atttattgat ccaaaagaca cgggaaaact tttaagacta attctatatg gcttggattc
     9301 tgttaattat agccggatta ttcgagatcg gctggccgct gggctttaaa ttagcaagta
     9361 tgcattccaa atattttatt tggtttatag gtttatcgat cttatccatg ggcttaagcg
     9421 gctatttctt atatctcgcc cagaaaagca tcccaatcgg tacggcttat gtaatctgga
     9481 ccgggatcgg ggctataggg actgttcttc ttggaatctt gtttttccat gattccgcaa
     9541 atatattcag gttattgttc ttatctttga tattgatagg gatcgtcggg ttgaaattag
     9601 tccattaatc cgggtaaaaa aacaccagta ttgccgtaag gctacgccag tataggcgtg
     9661 agcttacggc agtataggta tagggctacg actatactgc cgttaaccga cgcaactact
     9721 cgtgatgata aggctcgtta ttcaagatcg tcattgcccg gtaaatctgc tcgataaaga
     9781 tcagtcggat catctggtgg gaaaaagtca tcttgctcaa cgagatcttt tccgatgccg
     9841 ccttatacac agcttcacta aaaccgtaag gaccgcctac cacaaatacc aagcgtttcg
     9901 ggaccgtatg cattttcttt tccagataag tagaaaattg catggaggta aactccttcc
     9961 ctttctcatc cagcaacacc aaataatcgc cgggctgcaa ggcctttaaa atcaattctc
    10021 cctccttctc cttttgctgc gcctcagaga gattcttcac gttctttata tccggtatga
    10081 cttccatttc aaagggtata taatgtgtca agcgattttt atactcattg atagcctcca
    10141 caaaataacc ggcatccgtc ttaccaatca caatcagtcc aatcttcatc tacttacatt
    10201 tacatgttta gaaaggctaa gttacaagaa aaatacatac ctttgccact aattactcaa
    10261 taaaataaag aaagcttatg aaacgactct tacttacatt cgccttgata ttcgcgttcg
    10321 tatgtgcgca ggcggcggat attaccagta tatcaaatgc tttcaaggca ggaaatgcct
    10381 cctctctatc cggtgctatg gataaggtgg tggatgtagc cttgcccggt tcctctaaga
    10441 aatgtaacgg aagtgaggcc gtctctatgt tgtcctcatt tttcagttcg aataagcctt
    10501 ccggattctc ggtcgtacat catgcggata aaaaggaaag cggtttcctt gtcggaaagc
    10561 ttccgacgtc ttccggtgag taccgtgtaa acatcacgta ccgtgccgaa gggaatacag
    10621 cgatcataca atcaatcaga atagaataaa agatggacaa acttattgac gacttaatca
    10681 aattagcgtt tgccgaggat attggcgatg gcgatcatac caccttatgt tgcatccccg
    10741 agacagcgat ggggaaaagc cagctgatca tcaaggaaga tggcgtattg gccggcgtgg
    10801 aaatggctaa acgtatcttc cacgacttcg atccggaact gaaaatgacg gtctttatac
    10861 aagacggagc cgaagtgaaa aaaggggata tagcgttcgt ggtggaaggt aagatccaat
    10921 ccttattgca gaccgagcgg ttgatgctga acgttatgca acgcatgagc ggtatcgcta
    10981 ctacgactcg taaatacgcc aaggcgttag aaggcaccaa gacacacgtt ctagatactc
    11041 gcaagacaac tcccggtatg cgtatgatcg agaaagaggc cgtacgtatc ggtggcggca
    11101 tgaaccatcg catcggtttg ttcgatatga tcttattgaa agataatcat gtggatttcg
    11161 ccggcggcat cgagcaagcg atcacacgtg cgcaaaacta tctgaaagag aaaggaaaga
    11221 gcctaaagat cgagatcgag gttcgtaact tcgacgagtt ggaacaagcc atgaaagtag
    11281 gcggtatcga tcgtattatg ttggataatt tcaatatcga gaatacaaaa gaagcggttc
    11341 gccgcatcaa cggacgtttc gaggtagagt cttccggcgg tatcacgttc gacacattac
    11401 gtgattacgc ggaatgtggc gtagacttca tctccgtagg ggcattgact cactccgtga
    11461 agagcttgga catgagcttc aaagcctgct aaaacgaaaa acgatcattc tataaaaaaa
    11521 cagccttgag aagctcaact tcttgaggct gtttttccta tatctaccct attatcttga
    11581 ttcactatca tttctgatag aactattatc atttttaaaa cattgccatt ccttcctttc
    11641 ccgtactttt aagaacaaat tattcaacct aaaaatagta tcatgaaaga attgaaaatg
    11701 tttatagatg gcagattcat tgataatgag tctgggaaat ggatcaaggt attgaatcct
    11761 tctaccgaag aggttatttc actgatgccc gacgggacgg ttgaagatgc cagaaaagcg
    11821 atcgatgccg cagagaaagc gcagaatcaa tgggaaagaa cgccctccat agaaagggct
    11881 gcttatctga caaagatagc ggctggcatc cgtaagagag agaaggaact gaccgacatc
    11941 atcgtccgtg aaggaggcaa aacccaagga ctcgccaatg ttgaagttct ttttaccgca
    12001 gattatatgg attacatggc aggctgggcc cgtcggtacg aaggggaaat cattcccagt
    12061 gaccgccctc atgaaaacat tttcttattt aagagaccga ttggagtaac gacaggtatc
    12121 ctaccttgga atttcccatt ctttctagtc gctcgtaaag ccgcnnnnnn nnnnnnnnnn
    12181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12241 nnnnnnnnnn nnnnnnnnnn nnnngccgct cctaatatca cgaaagtttc tctggagtta
    12301 ggaggtaaag ccccggctat cgtgatgaag gacgcagata tcgatcttgc tgttaagtct
    12361 attattgcct ctcgtgtgat caataccgga caggtatgta attgtgccga acgggtttat
    12421 gtagacaaag cgataaaaga gaccttcatg gaaaaactag tcgccggcat gaagcaggta
    12481 aaagtaggaa atcccaatga ggtcgcggat ctggatatgg gaccgcttat tgaagccagc
    12541 gcgttggagt ctatggagaa aaaagtagag agagcgatcc aacaaggtgc taggctactg
    12601 tgtggtggcc ataggatcgg tacaaaagga tatttcttcg aaccgaccgt tttggattgt
    12661 gttacgcaga aaatggatat catacaagaa gagacttttg gccccgtgct accggttgtc
    12721 gaatattcgg acatcaacga cgctatcgca tgggcgaatg attgcgaata tggattgaca
    12781 tcttccgtat atacacaaaa cttggataac gcattcaagg taatgcgttc cttaaaattc
    12841 ggggagactt atattaaccg tgagaatttt gaggctatgc aaggcttcca tgcgggatgg
    12901 cgtaaatccg gaatcggtgg tgcggacgga aaacatggac ttgaggagta tttgcaaact
    12961 caagtggttt atcttgagac aaaggaataa aaaataagac taaagatccc ttcttgggat
    13021 ctttagcata tctacttaat ctaacgtcaa attaaactca tccctcaaac gacccaaggt
    13081 aggatttatc ttcatcagca gctctagctt ctccgtggat gtataagcca agtgcttctc
    13141 atttccctct acgatccgga cacgcatctg gatgcggctg ttattaagat gctggcggag
    13201 aaatggcagg atatggatcg cattattgat caattcctct tgctgccccg ggttatgtac
    13261 agctacctcg aaataataat tctcttgcaa ggtaggcttg caattgatca tcgtattctt
    13321 aagatacact ttcttgtcaa tcgttgcggc gtaattatcc cattcacgaa ccaaggaatc
    13381 attgtcaaag ggagttacta cctcctttac gttcgttgtc gcttgttgaa cggtttgttg
    13441 cttaggcttc tccactccga tctccttcat ggagattccc atcggacgag ccgttctacg
    13501 aaccgaatta ggcgctgtag acggaggtgg cgcaggaacc gagctcggca tgtgcgtact
    13561 cataacttgt ggagcaccgg ccgctgccgt aactgaagga gcttgaggcg gctgttgagg
    13621 cttcccgcta ttcaccgctt gagaagacgg attcgtccca gcaatcggct caattaacgc
    13681 ttttttttta tcgtcggcgg ctacctgtgt taattgacag agctgaatca acgtcaattc
    13741 caataaaaga cgcttattgc ggctggcacg ataattcaaa tcgcacgtat tcgccagctc
    13801 tatcgccttg aacagaagtt gatccggaca atgtttcgcc atctccttat atcgttcacg
    13861 tatagaagca cccacctcga atagcaccaa ggtggactca tcccggcata ccaataagtc
    13921 ccggaaatgc ccagccaaac cggttatgat attctgcccg tcgaatcctt tgcctaatat
    13981 ctcattcaag atcaataaag aagcccgcac attgccggat aagatcgcat ctgtcagacg
    14041 aaaataatac tcataatcca gcacgttcaa gttatcgata accgcttgat acgtgatatt
    14101 gccattcgtg aaacttacca cttggtcaaa gatagacaaa gcgtcgcgca tacctccatc
    14161 cgccttctga gcgatcacgt tcaaggcttc cggttccgct gttaccccct cttgcgaaga
    14221 gacatattgc aaatgctcca ccatgtcggc gatggatata cgggagaaat catagatctg
    14281 acaacgggaa aggatcgtgg gaagcacctt gtgcttctcg gtcgtagcca agataaagag
    14341 agcatgatgc ggaggttcct ccaatgtctt caagaatgcg ttgaaagcgg cggttgtcaa
    14401 catatggacc tcgtcaataa tgaagacttt gtatttaccg attggaggcg ggatacgcac
    14461 ttggtcgatc aaggtacgga tatcgtccac cgagttattc gaggcggcat ccagttcatg
    14521 gatattgtaa gaacgctgct cattgaaagc ccggcacgac tcgcacgcat tgcaagcctc
    14581 gccatccgcc gtcggattca agcaattgat cgtcttcgca aagatacggg cacacgaggt
    14641 ctttcctact ccacgaggac cgcaaaacag gtaagcatgc gctaatttgt tactttgtat
    14701 cgcgtttttc agcgtagtgg taagagactt ctgccctact acactccgga aagtggacgg
    14761 gcgatatttt cttgccgata caatataatt atccattctc tgctttttat tgataagaca
    14821 aagataaaca aaataattca ttatcttcgc gaaaacgatg ttctgatgtc acgcataaaa
    14881 gagttttaca taaagtatct atcgtggatc aacgcttatt ggttggttac catcgtgttc
    14941 cttatcgtca cctttacggt gggcgatagc agcctgtata aacgctatac gtacgacgag
    15001 aaaatacgcg gtttggagaa agagatcaaa cattaccaaa aggagatcga gatcaacagc
    15061 aagaaattaa acgaccttca tacggacaag gagggactgg aacgtttcgc ccgtgaagag
    15121 tatttcatga aaaggtcgaa cgaggatgtt tttattatca aggacaaata aatgaatcaa
    15181 caaatcagat cgattatttt cggcgtagcg ggattactcg tattagccgg tgccatattg
    15241 tttcttactc attgggctgt cgccccttat ttattcgctg tcggtgcggc gggtatagcc
    15301 gtttgctatc tgacccttcc ggttaagg
//
