LOCUS       c00536_gnlPro..         5635 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NFPKKKKK_536.
ACCESSION   c00536_gnlPro..
VERSION     c00536_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:01:58
            Original ID  :: gnl|Prokka|NFPKKKKK_536
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5635
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5635
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:5633]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..5633
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..5635
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..5635
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..1492
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg536_1"
                     /sec_met_domain="ILVD_EDD (E-value: 3e-184, bitscore:
                     601.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPM
                     EAGEWNGQHLDLIDAMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAI
                     GLALPGNGTIVATHENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMT
                     LDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDMLSRKAPCLCKVAPNTQKYHIQDVNRA
                     GGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFN
                     LVLGSQGAYYKELDKDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIW
                     KFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLG
                     KECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEE
                     LAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID"
     CDS             1540..3237
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg536_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.9e-48, bitscore:
                     150.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRTFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTKERSIVTSGGLGTMGFGLPAAIGATFGRPDRMVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKAAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             3256..3819
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg536_3"
                     /sec_met_domain="ALS_ss_C (E-value: 2.7e-20, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             3819..4562
                     /locus_tag="ctg536_4"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEA
                     NENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             4626..5633
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg536_5"
                     /sec_met_domain="IlvN (E-value: 6.4e-48, bitscore: 150.9,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.1e-38, bitscore: 120.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFSIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTA"
ORIGIN
        1 cgtagaatat atggtcaatg cgcacaaggc ggatgcaatg gtatgtatca gcaactgcga
       61 taagattacc ccagggatgc tgatggctgc catgcgcctg aatatcccta ccgtatttgt
      121 atccggtgga ccgatggaag ccggagagtg gaacggtcag catctggact tgatcgatgc
      181 catgattaaa tcggcggacg acagtgtaag cgatcaggaa gtagcgaata tcgaacagaa
      241 tgcctgtcct acctgcggat gttgttccgg aatgtttacg gcaaactcga tgaactgtct
      301 gaatgaagct atcggcctgg ctcttccggg aaacggcaca atcgtggcta cgcacgaaaa
      361 tcgtacgaaa ctgtttgaag acgcagccaa actgattgtg gaaaatgcaa tgaaatatta
      421 tgaagaaggt gacgaaagtg tacttccccg cagtatagct acccgtcagg cattcctcaa
      481 tgccatgacg ctggatattg cgatgggcgg ttctaccaat acggtgcttc acctgctggc
      541 tgtggcacat gaggcaggag tcgatttcaa gatggacgac atcgatatgc tgtcacgcaa
      601 ggccccctgc ctgtgtaaag ttgctccgaa tactcaaaaa tatcatattc aagacgttaa
      661 ccgtgcgggt ggcatcattg ctatcctggc agagttggca aaaggtggtc tgattgatac
      721 ttccgttctc cgtgtggatg gcatgtcgct ggcggaagcg atcgatcaat attcgattac
      781 cagcccgaac gtaacagaaa aagcaatgag taagtattca agtgcggcgg gaaatagatt
      841 caatctcgta cttggttctc agggagctta ttataaggaa ttagataaag atcgtgcgaa
      901 cggatgtatc cgtgatctgg agcacgccta tagcaaggac ggaggcttgg cggtactgaa
      961 aggaaatatc gctcaggacg gttgcgtagt aaaaacggcg ggtgtagacg aaagcatctg
     1021 gaagtttacc ggacctgcca aagtattcga ctcacaagaa gcagcctgtg aaggcatcct
     1081 cggaggccga gtcgtcagcg gcgacgttgt cgtcatcacg cacgaaggtc cgaagggcgg
     1141 tcctggtatg caggaaatgc tttacccgac ttcttatatc aaatcccgtc acctcggcaa
     1201 agaatgtgcc ttgattaccg acggacgttt cagtggtgga acttccggat tgagtatcgg
     1261 acacgtttct cccgaagccg ctgccggagg gaatatagga aaaattgtag atggagacat
     1321 catcgaaatc gacattcctg cccgaacgat taacgtgcga ctaacagatg aagaactggc
     1381 tgcccgcccg atgactcccg tcacccgtga ccgttacgtg ccgaagagcc tgaaagcata
     1441 cgccagcatg gtaagctctg ccgataaggg agcagtgaga ttaatagact gatccacttc
     1501 attatccatt atgaatcatc cattatccat taaagaacta tgagtaagga cttaataaca
     1561 ggcgcagagg caatgatgcg ttctctggaa catcagggag tgactaccat tttcggttat
     1621 cccggcggtt ccatcatgcc tacgttcgat gccctgtacg accatcaaaa tacattgaac
     1681 catatcttgg ttcgccatga acagggagct gcccatgcgg cacaaggcta cgcccgtgta
     1741 tcgggtaaag tcggtgtttg cttggtgaca agcggccccg gagcaaccaa tacgatcaca
     1801 ggtattgcag atgcaatgat agacagtacg cctatcgttg tcattgcagg acaggtggga
     1861 acaggctttc ttggaacaga cgcttttcag gaagtcgatc tcgtaggtat cactcagcca
     1921 atcgctaaat ggagctatca gattcgccgt gccgaagacg tagcctgggc aatagcacgt
     1981 gctttctaca ttgccagtag tggtcgtccc ggtccggtgg tactcgactt tgccaagaat
     2041 gcgcaggttg aaaaaacgaa atacgagccg acaaagcagg agtttatccg cagctatgtt
     2101 ccggttcccg atacagacga agaatcggta aaggctgccg ccgaactgat caataacgcc
     2161 gaacgcccgc ttgtcttggt aggacaggga gtggaactgg gaagcgctca ggaagaactg
     2221 cgtaccttta tcgaaaaggc ggatatgccc gcaggttgta ccttgctcgg actttccgca
     2281 ttgcctaccg accatccgtt gaataaagga atgctgggta tgcacggaaa tctgggaccg
     2341 aatatcaata ctaacaaatg tgatgtactg attgctgtcg gtatgcgttt cgacgaccgt
     2401 gtgaccggta atctggctac ttacgccaaa caagcgaaag tgatccattt tgatattgat
     2461 ccggcggaag taaataagaa tgtaaaggta gacattgccg ttttgggcga ctgcaaaaag
     2521 acgctggctg ctgtgaccgg actgctgaaa aagaaccggc acactgagtg ggtcgatagt
     2581 ttcaaggaat atgaagcggt agaggaagaa aaagtcattc gtcccgaact tcatcctgca
     2641 acggattcac tgagtatggg cgaagtggtg cgtgcggtaa gcgaagcgac ccgtcacgaa
     2701 gccatattgg tgacagatgt aggtcagaat cagatgatct ctgcccgcta ctttaaatat
     2761 accaaggaac gtagtatcgt tacttcgggc ggactcggca cgatgggttt tggccttccg
     2821 gcagctatcg gagctacttt cggccgtccc gaccgcatgg tatgcgtatt tatgggtgac
     2881 ggcggactgc aaatgaatat tcaggagctg ggtacgatta tggaacagaa agctccggtg
     2941 aagattatct gcctgaacaa taattatctc ggcaacgtgc gccaatggca ggccatgttc
     3001 tttaatcgcc gttattcatt tactccgatg ctgaatccgg attacatgaa aatcgcttcc
     3061 gcctacgata ttccttccaa acgtgtcttt tcacgggagg aattgaaagc ggccatcgac
     3121 gaaatgctct cgacagacgg gccgttcctg ctcgaagcct gtgtggtaga agaaggcaat
     3181 gtcctcccga tgacccctcc gggcggttca gtcaatcaga tgttgctgga atgttaatcc
     3241 ttaatttaga aagttatgag tgataagaca ttatatacga ttatagttca ttctgaaaat
     3301 atagccggat tgctgaatca ggtgaccgct gtatttaccc gtcggcaaat aaacatcgag
     3361 agtttgaacg tttctgcttc ttccattaaa ggagtacata aatatacgat cacagcgtgg
     3421 actgataagg acactatcga aaaggtggtg aagcagatcg aaaagaagat tgatgtgatt
     3481 caggcgcact attttacgga agacgagatt tatttccatg agatagcctt atataaggta
     3541 tctactcctg cttttcagga gactccggaa gcatctaaag tgatccgcag atataatgcc
     3601 cgcattgtag aggtgaatcc ggtattctct atcgttgaga agaacggcat gagtgaagag
     3661 attacttccc tttacgaaga acttcgggct ttgaaatgcg ttctgcaatt tgtccgttcg
     3721 ggtcgtgtgg ctattactac cagctgtttc gaacgtgtga atgagttcct ggacggacag
     3781 gaagcgaagt ataagcaaag taaaaaggaa caggagtaat gagtgaagaa aataaaatag
     3841 ggacttatca gtttgtggca gagccgttcc acgtagattt taacggccgc ctgacaatgg
     3901 gcgtgctggg aaatcatctg ctgaattgcg caggttttca tgccagcgac cgtggatttg
     3961 gtattgctac gctgaacgag gacaattaca catgggtgct ttcccgtctg gcgatcgagc
     4021 tggacgagat gccttaccaa tacgagaagt tctcggttca gacatgggtg gagaatgtct
     4081 atcgtctctt taccgaccgt aactttgctg tcattgacaa ggatggaaag aagatcggct
     4141 atgcccgttc cgtatgggcg atgatcaatc tgaatactcg taagcctgcc gatctgttgg
     4201 cattgcatgg aggaagcatc gtcgattata tatgcgatga accctgcccg atagaaaagc
     4261 cttcgcgtat caaggtgaca agcaatcagc ctgttgcgac gctgacggca aaatacagtg
     4321 atatcgatat taacggacac gtaaacagta ttcgttatat cgagcacata cttgacttgt
     4381 ttccgataga actgtatcag acgaaacgta tccgccggtt tgaaatggcg tatgtggctg
     4441 aaagttattt cggagatgaa ctctctttct tctgtgatga agcgaatgaa aacgagtttc
     4501 atgtagaggt gaagaaaaac ggcagcgagg tagtatgccg ttccaaagtg atatttgaat
     4561 aatatagagt ataaaatcaa ttaataacag atggcgcaag tcatcaaaac aaaaaaacaa
     4621 aaaaaatggc acagttgaat tttggcggaa ctgtagaaaa tgtagttatc cgtgatgaat
     4681 ttccattgga aaaagctcgt gaagtattga aaaatgaaac aatcgctgta atcggttatg
     4741 gcgtacaagg tcccggacag gctctgaacc ttcgtgataa cggtttcaat gtaatcgttg
     4801 gtcaacgcca gggaaagaca tatgacaaag cggttgctga cggatgggtt ccgggtgaaa
     4861 ctttgttcag tattgaagaa gcttgcgaaa aaggtacgat cattatgtgc ctgttgtctg
     4921 atgcagcagt aatgtctgta tggcctacta tcaagcctta cctgactgca ggaaaagctc
     4981 tttatttctc tcatggtttt gctattacat ggagtgaccg cacaggtgta gttcctcctg
     5041 cagatatcga cgtaatcatg gttgctccta aaggttcggg tacatccttg cgtactatgt
     5101 tccttgaagg tcgcggcttg aactcttctt acgctatcta tcaggatgca acaggcaacg
     5161 ctatggacag aacaatcgca ctgggtatcg gtatcggttc aggttatttg ttcgaaacaa
     5221 ctttcatccg tgaagctact tccgacctga caggcgaacg tggttcactg atgggagcta
     5281 tccagggtct gttgctggca caatacgaag tgttacgtga aaacggtcac actccttccg
     5341 aagcattcaa cgaaactgta gaagagctga ctcagtcatt gatgccgttg tttgcaaaga
     5401 acggtatgga ctggatgtat gctaactgct ctactacagc tcaacgtggt gctctcgact
     5461 ggatgggccc cttccacgat gctatcaaac cggtagttga aaagttgtat cacagcgtga
     5521 agactggtaa cgaagcacag atttcaatcg actctaactc caaaccggat tatcgtgaga
     5581 aactggaaga agaactgaaa gcattgcgcg aaagcgaaat gtggcagact gccgt
//
