LOCUS       gnlProkkaNDKJPDAE_37   13124 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NDKJPDAE_37.
ACCESSION   gnlProkkaNDKJPDAE_37
VERSION     gnlProkkaNDKJPDAE_37
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:09:04
            Original ID  :: gnl|Prokka|NDKJPDAE_37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13124
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..159
                     /locus_tag="ctg37_1"
                     /transl_table=11
                     /translation="MNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLLKQQLSAVCHGM
                     QELCEIN"
     protocluster    1..13124
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3810:8124]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3811..8124
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13124
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13124
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             177..2588
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg37_2"
                     /sec_met_domain="Poly_export (E-value: 8.6e-18, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2599..3747
                     /locus_tag="ctg37_3"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3811..4530
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_4"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.3e-15, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4551..5852
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_5"
                     /sec_met_domain="CTP_transf_like (E-value: 1.6e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.6e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.8e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5869..6993
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 8.6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.5e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             7003..8124
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg37_7_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_7"
                     /sec_met_domain="Aminotran_5 (E-value: 1.2e-30, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        7093..8100
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_7_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg37_7_Aminotran_5.1"
                     /locus_tag="ctg37_7"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             8121..8264
                     /locus_tag="ctg37_8"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8503..9951
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_9"
                     /sec_met_domain="Polysacc_synt (E-value: 1.2e-30, bitscore:
                     99.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSAIERFSLQGVQFIIQIILARLLLPSDYGMIGMLAIFLQVAQV
                     FIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIADFYNMPTLVLVI
                     RFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWMAYVGCGVWALVW
                     QTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLINTVYRNLYTIVIG
                     KKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCLTNAYRNYIRLSS
                     YIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLNLLWVKGRS
                     DLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYYTNSLIDLTLKLQ
                     VKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLSFLFKLDSFFCIL
                     TLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9905..11164
                     /locus_tag="ctg37_10"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             11173..11922
                     /locus_tag="ctg37_11"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11922..12962
                     /locus_tag="ctg37_12"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 tataatgtgt cgatgtacgc caatccggaa gacgaagaaa gaaaacaggc tgttttgacc
       61 cgttctctgt ctcttctcga tgttcttccc ccttctcttc ttaagcaaca gttatctgcc
      121 gtctgtcatg ggatgcagga actgtgtgaa atcaactgaa acttttttat ttgtcaatga
      181 aaatacaacg actttttagc attctactat tttgtttgat gctgggaagt ggctcgctta
      241 tggctcagtc catgagtgac tcacaggtac tggaatatgt aaaagacggc atccgccaag
      301 gcaaggaaca gaagcagctt gcttccgaac tagcccgtaa gggtgtaacc aaagaacagg
      361 caatgcgtgt gaagcagcta tacgagcagc agaacaatgt aaatacctcg aaatcaacgg
      421 gcacggacat caacgaatcc cgcctgcgtg aagagactaa gaagaatact tccgatatgc
      481 tggaggatca tccgactact caggaccttg cccgtggtga tcaggtcttc ggacgtaaca
      541 tcttcaatac ccgcaacctg acgttcgagc ctagtgtcaa ccttgccact cctgccaatt
      601 accgtcttgg tcccggtgat gaagtcatca ttgatatctg gggtgcgagc cagaacacga
      661 tccgccagca aatctctcct gaaggtacta tcaacattca gaagatcggc cctgtcaacc
      721 ttagcggtat gacagtctct gccgccaatg actatctgaa gaacgccctg aataaaatat
      781 ataacggtct gaataatact accgatccta cttccgacat ccgtctgacg ttaggtaata
      841 tccgtactat tcagattaat gtgatgggag aagtcgtaca gcccggtacc tacgcccttt
      901 cttccttctc taccgtcttc catgcgcttt atcgtgcagg cggtgtgagt gatatcggta
      961 gcctccgaaa cgttcagttg gtacgcaacg gaaagaatat tgccaccatc gacgtctacg
     1021 aattcattat gaaaggcaac acacaggatg acatccgcct acaggaaggt gacgttgtga
     1081 ttgttcctgc gtatgatgtc ttggtaaaga tcagcggcaa ggtaaaacgt cctatgcgtt
     1141 ttgaaatgaa gaaagacgag aaccttgcta ctctcattaa atatgccggc ggctttgaag
     1201 ctgatgccta cacccgttca ttacgtgttg tccgtcagaa tggtgaggaa tacgaagtca
     1261 acacagtcaa agatatagat tacaacattt ataaaatgcg taacggtgac gtagtaaccg
     1321 ccgaagccat ccttaaccgc ttcacaaaca aactggaaat ccgtggcgct gtctatcgtc
     1381 ccggtatcta ccagctcagc ggtaaactga acacgatccg cgaacttgtc catgaagctc
     1441 agggtctgac cggtgacgct ttcctgaatc gtgccgtcct ctatcgccag cgtgaagacc
     1501 tgaccagtga agttgttcag atagacatta agtctatcat ggacggcact tccccaaacc
     1561 ttgccctaat gaagaatgac atcctctaca ttccaagtat ccatgacctg gaagaccggg
     1621 gtaatgtcac agttcacggt gaggttgccc accctgattc ctatccttat gcggataaca
     1681 tgacacttga ggatctgatc attcaggccg gtggcttgaa agaagccgcc tctactgtcc
     1741 gtattgatat atcgagacga atcaagaatc ctcgtagtac tgcggataat gatacgattg
     1801 gtcagatgta taccttctct ttaaaggatg gttttgtaat agatggtcag cccggtttta
     1861 tccttgagcc ttatgatcag gtttatgtcc gtcgcagtcc gggctatcag gcacaacaga
     1921 atgtagccat tgaaggtgaa atccttttcg gaggaaatta cgccatgacc agccgtgagg
     1981 aacgtctttc cgatttagtg aataaagccg gcggtccgac caattatgcc tatctgcgtg
     2041 gtgcgaaact gacccgtgtg gctaacgcta gtgaaaagaa acgtatgggt gatgtaattc
     2101 gccttatgag caggcaattg ggcgaagcca tgattgactc tttgggtatt cgtgttgaag
     2161 atacttttac ggttggaata gatttggaaa aagccttgag caatcctaaa agtaatgccg
     2221 atcttgtctt acgtgaaggt gatgtgatct ccatacctaa gaatactaat actgtaacta
     2281 tcaatggtgc tgtcatggtt ccgaatacgg tttcttatat gaagggaaag aatgtggatt
     2341 attacctgaa tcaggccggt ggctgttctg ataatgcaag gaagagtaag aagttcattg
     2401 tttacatgaa tggtcaggtg acgaaggtta agggtagtgg taagaaacag attgagccgg
     2461 ggtgtgagat tattgtgcct ggtaaggcta agaagaaagg gaacatagct aatattttag
     2521 gttatgctac ttccttcagt tctttgggaa tgatgattgc ttctattgct aatttgataa
     2581 agaaataaat gacctattat gattgaaaag caatcttatc aagaaccgtt ttctgaagtg
     2641 gataaaagga aagatgatga aatggaaata gacttgatgg ctatttttta taagattatt
     2701 actgttcgtg gagtactatg caaagctgct ggagtgggag taataattgc tatagtggtg
     2761 gcattgagca ttcccaagca atatacagta aaggttaccc tttctcctga aatgggtaat
     2821 gcgaagggaa gtaatggttt agccggactt gctgcctcgt ttttgggaga tggggctcta
     2881 ataggggaaa gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact
     2941 ccttttttat tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg
     3001 actttggggt cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt
     3061 ccgggcatag taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt
     3121 ggagggcggc aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt
     3181 aaaaagaaga ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc
     3241 ttacaaaatc cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa
     3301 tatattattg ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg
     3361 tttaaagaac gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac
     3421 gcccatgata atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac
     3481 atgagtttgg cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc
     3541 aaagtacagg aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa
     3601 ccttcaggta tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt
     3661 actctcgtgt gggtgttttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa
     3721 aataaggaga tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttacatca
     3781 attaaattca cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg
     3841 ggcatgggaa cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg
     3901 ggaggtattc caatgatagt tcgttctatt gatactttgt tatcatgtga cattgagcga
     3961 attgtaatcg gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct
     4021 atgcttgaaa cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat
     4081 aatacgcggg agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt
     4141 gagaaacaag caataatgag cttattggag tgtcctgcgg cagatgcaat gctaataact
     4201 ccagtgacaa agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct
     4261 tcatgttctg tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa
     4321 ctatccggtt ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa
     4381 cccaatttgg gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat
     4441 gtgcataaag tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat
     4501 gcagagaaat atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga
     4561 cagtttatat tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg
     4621 aggctactaa atacggtgat gttataattg gtcttcttac agataaagct attgcggagc
     4681 ataaacgcct tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag
     4741 gcgtatgtaa agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta
     4801 aacctgacta tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg
     4861 tgcgcgtatt tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt
     4921 tgggaattaa ttcatcttct ttggataaag atattaaggc tataggtaca acccctgatg
     4981 tacgtttaaa atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag
     5041 ctcatgatgg actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga
     5101 gggaagtatt tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac
     5161 ctgatattga ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt
     5221 gtactactaa acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat
     5281 ttacagtacg cactttagaa cgtcatggaa tttcagctat aataattgaa gataaagttg
     5341 gattaaaaaa gaattcattg tttggtacag atgttattca aactcaagat acaatcgaag
     5401 gtttctgtaa taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta
     5461 tcgctcgtat tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt
     5521 ttgcatatgt ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg
     5581 aagatataaa agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg
     5641 ttgtgcctac tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata
     5701 taattattta tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa
     5761 agataatatt agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaaag
     5821 aaatattgga actgattcca ggtactaaat aaaaagagga atatcattat gttaagcgta
     5881 gaaaaagttt atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac
     5941 tcattactaa aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc
     6001 atagctgcta atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt
     6061 aaggttcctg tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg
     6121 tctcttgcag atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt
     6181 gaaccgggaa caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg
     6241 ttgaaagcaa tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt
     6301 cagctccatg atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt
     6361 cggaaagatg tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta
     6421 tctcgtgagg atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt
     6481 tctactactg gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt
     6541 catgaacatg attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt
     6601 attgctatag caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt
     6661 atgcatttag gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt
     6721 ttgtttaaca atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta
     6781 gatattccgg ctattgtccg ggggagcgga tataagcata cttatactgt ttgtacaaaa
     6841 gttgaaattg aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa
     6901 ataaaggtta aaatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag
     6961 aataaggagc attttatgga ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa
     7021 atattattaa atcctgggcc tgccactact actgacagtg taaaaatggc acaagttgtt
     7081 ccggatattt gtcctcgcga gaaagaattc gcaggtatga tgaaacaact tcgggacgat
     7141 ttggtcagag ttgctcatgg gaatttggaa aaacataccg ctgtattatt ttgtggctca
     7201 ggaaccatca atattgatat atgtctaaat tctcttcttc ctgaagacaa aagggtgctt
     7261 atagtgaata atggggcata tagtacccgt gctgtagaag tgtgtcaata ttatggtttg
     7321 cctcatatta atttggaatt ttccgtttac gaacgtcctg atttatcggt ggtggaaaat
     7381 gtgttgcaag aaaatcctga tatagctatg gtttatacta ctcatcacga gacgggtaca
     7441 ggaattctga accctattcg cgagatgggc gctatagctc ataaatatca ggctaaattt
     7501 gtcgtcgata ctacttcttc tttgggcatg attccttttg atatagagaa agataatgtg
     7561 gatttttgta tggcatctgc tcaaaaagga cttcaagcga tgacaggtct ttcttttatt
     7621 ataggcaatg aggaacagat taagttttca aaaaaatatc ccaagcgttc ttactattgt
     7681 aatctttatt tgcagtatga gaattttgag agaacaggtg aaatgcattt tactccaccg
     7741 gtacaaacta tttacgccac tcgtcaggca ttaaatgaat attttgaagt gggtgaagaa
     7801 gctaagtttg cccgtcacaa aagagttttt gaggctattc attcaggtat aaatgaaatt
     7861 ggtcttaaaa gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc agttcaatac
     7921 ccagaagatc ccaactggga ttttgagaaa atacatgatt attgttatga gcgtggattt
     7981 acgatttatc caggtaagat atcaactgag gatactttta gaatctgtgc tttaggagag
     8041 atagaagtag atgatattga gaacttcttt aaagtactaa aagctgcatt aaatcattat
     8101 aacgtcacat taccgatgtc atgattgcag aaatattatt gaagattcgt catttttatt
     8161 tttcccttcg tggtatacac ttccatccgg aaagtgttat ttctggagtg cctattcgta
     8221 gctttcgctt agtaggcaaa tatggcaata ttaatttgag gtgatgcatt aggagttctt
     8281 tattcttata aaaaggcatc ggtagttata ggagataatg tttgtgtagg gtaatttgct
     8341 tttagtggga gagaccatat tagaattgcg gtaaggggcg aagaagataa taaccaatta
     8401 gtgagaatat tggaaaaata taattgatat cggtaaatgt agttgttttt atactgtatt
     8461 taagtaatgg aaaatctaaa gcagaaaact gtatcaggaa taatgtggag cgctatagaa
     8521 cgtttctctt tacaaggagt acagtttata attcaaataa tattagctcg tttgttacta
     8581 ccatcggatt atggtatgat cgggatgtta gctatttttc ttcaagtcgc tcaagtattt
     8641 atagatagcg gttttacaaa tgctttaatc cagaaaaaag atagaactga agaggatttt
     8701 gccactgtct tttattttaa tattcttgtc gcagtattat tctatggtat attgtttttt
     8761 tcggcttctt tgattgcaga cttttataat atgccgactt tagttcttgt aattcgtttt
     8821 atagcattgt cgttgataat aaatgcttta tcggctattc acagaacgaa attaattatt
     8881 tctgtaaact ttaaaactca atctaaaatt tcattaggtg cagcttttat atcaggcgtg
     8941 attggaatat ggatggctta tgtcggttgc ggggtttggg ctttagtttg gcaaactctc
     9001 ttaaatagta taattttgac aattttgttt tactgtttag ttcattggaa acctttacat
     9061 actttctcca aaagttcttt tgaaagatta ttcaatttcg gatctaaatt attgatctca
     9121 agtcttatca atacagtata tcgtaatctg tataccattg taataggaaa aaagttttct
     9181 gttgtagagc ttggttacta tacaagagca gaacaatttg ctatttttcc ttccaataat
     9241 ttaaatgctt tagtttctag agtagcgtat cctattttaa gttccattca agatgatgat
     9301 aaatgtttaa caaacgcata tcgaaattat atcagattat cctcatatat aatttttcct
     9361 ttaatggtag gtttacttgt tttggctaat cctattatta gtctattgtt aacagataaa
     9421 tggtctgggg ttgttattct tttacagata ttatgtttgg attggatgtt tgatcatttg
     9481 agccaaatta atttgaattt attatgggtt aaaggaagat ctgatctgtc gttacgtctt
     9541 gaaataataa aaaagacgat tgctatattc attctttttg tgtcaattcc atttgggctt
     9601 gaggtgatgt gttggggtag agttatttac tctctgatag cgacatattt gaatacatat
     9661 tatactaatt ctcttattga tttgacctta aagttgcaag ttaaagatgt atttccaagt
     9721 ttaatactct ctttcataat gggggggatc gtttttatat gtatttcttt ctttgaaact
     9781 gatatagtaa aaattgtgat tggatgtatt actgggatgt ccttctatat tttactttct
     9841 tttcttttta agctagattc ttttttttgt attttaacat tgatcattaa aactaaaaac
     9901 atagatgaaa atattaaaaa agatttttca agtaatagta aagataatta accattgtgt
     9961 gccagttgat agtagatcat tgtattttat tcctcatcct aattgtagaa cagataaata
    10021 tgatattata aattattcgt cagataatgt tctcgttctg ttaaattatt tgctaaaaaa
    10081 agatagtgct gaatattata aaatatatgt tgaaatttat gattcttctc gtatttcaga
    10141 atatcaagaa tatatttatg gcataaatcc taatattagg tgtacttttt tatgtgcatg
    10201 tgttggacgt tttttcttta ataaagtatc ttttaaggat atgttgtatg cctttttttg
    10261 tttttgtaga gcaagtaaat gttttacagc tactttttat tatgattttt catttaaaaa
    10321 acgctctcaa cagattattt gtttggggta ttatactcca ttcaaagatg attatcatat
    10381 gggagatcat tcttatgata aatttcgtaa tacaacatgt aactcatttg attactctat
    10441 tgctacttct tgtttaagtg ctagaataat ttcaatagat tgtggaatct catatgataa
    10501 attcaaagtc ttaggatttc ccagaaatga tttgttgata tcgaaaaata attgcaatgt
    10561 tattaaaaga gaaatttcga aatttgcggg atatgatgta actaaatata tagtttatac
    10621 tccaactttt cgtgattatg agactgttac tgaaggtaat ttgcgttcaa tactcggata
    10681 tgttgattgt gatttgttga agttatcgaa aatactattg aagtttaatg cggctttaat
    10741 tcttaaatta catcctttgc agaataaaac agtcttaaaa aaagatttac ccaaaggtat
    10801 acttgttttt gaacaaacat ataaatatgg attgtatgat cttttgtcat tttcagatgg
    10861 aatgattact gattatactt ctacctattt tgatttttta ttagtaaata agccagtcat
    10921 atttaatttc tacgatattg aagaatatcg tagagtaaga ggtttctcat ttgagccaat
    10981 agaatttttt tgtgcaggtg atattgttta caattataat gaattgatag atgctgtgat
    11041 gggacttctg gctgggaaag atattcatgc tgaacatcga cgtcatattt ctttattgat
    11101 gaatcaattt caagatgata attcaacaaa gagaatatgt gacatatttt taaatgaaat
    11161 ataataaata aaatgaatta tgcatttgtg gtgcaggcac gtttaggttc tacacgtttg
    11221 cctggaaaaa tattgaaacc tttctatggt aatcaatcga ttcttgactt aatggttcat
    11281 aagctttctg ctatatcgaa tattccagta attattgcta caacaaattc tgttatcaat
    11341 gaacctattg aaaagaaggc acttgcatta ggggtaaagt gcttcagagg tgaggagaat
    11401 gatgttttaa aacgattcat tgatgttgct gaatattttg atatacaggg tatattccga
    11461 atatgttctg ataatccatt tttagatgta catgcggcaa ggcaattggt cgaaatagca
    11521 atgaaatctt gtaacgatta tataagtttt gatattgatg gtactccatc aattaaaact
    11581 catttcggtt tttggggaga atttgtaacg cttgatgcgc tgaagcgagt tataggattt
    11641 actgatgatt tattgtatcg tgaacatgtt actaattata tatatagtca tcctgaactt
    11701 tttaatattc aatggatttc aggatctcca gtcgtgtcaa aacatcataa tattcgactc
    11761 acgattgata cgttagaaga tttttctgta gcacagagaa tatataggga tttacaagaa
    11821 aaaagagtgg aaatatcgat agaagtgatt gtagactatg ttcgaagaca tgcagaatac
    11881 attcaactga tgaaacaaca aataaaaaaa aattctaaat aatgaagaat acttatatta
    11941 ttggtgaaat agggcagaat cataatggtt ctgttgactt ggctaagttg attattgaat
    12001 taatctcacg acctgtacat gaggatgttt ttggtatgga tttcatgcca atgaatgctg
    12061 ttaaaatgac taaaagagat ttatcagaag aattggctgt ttctcaaatg aatcaaatat
    12121 atgacaatcc taattctttt gggcgtactt atggtgaaca tcgtgctttt cttgagcttg
    12181 atgatcaagc gcattttgag atttataaat atgctaagtc attaggatta gattttatcg
    12241 agacgttatg tgccaaagga tgtctgtctt tgcttaaact gttcacaccg gataggctaa
    12301 aagttgctag tcgtgatttg actaacttac cattgcttga agcattagca gaaactcata
    12361 ttcctattat attatcgaca ggaatggctg gtcaaagaga acttgacaat gcattagatg
    12421 tgataacgag atatcatagt aatatagcta ttctacattg tgtatctcag tatccaactc
    12481 atccaaataa tttgaatcta cgtacaataa catatttgaa gaagcattac aataagtttg
    12541 agataggttt ttctgatcat acaataggta tttctgctgc tacagctgct gtagcgatgg
    12601 gagcggaaat tatagaaaag catgtaacaa ttgatcggca tatgaaagga acagaccagc
    12661 ttggctcttt aggtccagat ggggttaatc gtatgattcg agatattcgc atagcagagt
    12721 gttggcttgg tactgaagat ctttatatag aaaaaggggt ggagaagtct aagataaaac
    12781 ttgaacgttc tattgccact cgaaaatata ttccagcagg tagtattatt caagagtcgg
    12841 acattcattt actgagtcct ggtgatggtt ataaatggat agataaaaaa aatgtaattg
    12901 gtcattttgc taaacaagat atatcagcga atgaaataat atatcctgat tttattgaat
    12961 agatatattc ctactgcaac ttgtattacg gtatagagta ctgcctgcta taagctaagt
    13021 agtgattaat aaataagggt aaaatactaa aaaaatgaaa gagataaagc ttatacttac
    13081 agatattgat ggcgtttgga ctgatggcgg aatgttttat gatc
//
