LOCUS       gnlProkkaNDKJPDAE_69   12579 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NDKJPDAE_69.
ACCESSION   gnlProkkaNDKJPDAE_69
VERSION     gnlProkkaNDKJPDAE_69
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:09:04
            Original ID  :: gnl|Prokka|NDKJPDAE_69
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12579
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12579
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2231:2579]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2232..2579
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12579
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12579
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             113..508
                     /locus_tag="ctg69_1"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEASATETPAPAAE"
     CDS             799..2187
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 90.5; E-value: 1.4e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg69_2"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKVENKKKGYGLEEA
                     NIQK"
     CDS             2232..2579
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_3"
                     /sec_met_domain="PF05402 (E-value: 6.2e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 2.3e-09, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(2569..2856)
                     /locus_tag="ctg69_4"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNNYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(2878..3942)
                     /locus_tag="ctg69_5"
                     /transl_table=11
                     /translation="MKKLIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             complement(4016..5527)
                     /locus_tag="ctg69_6"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVETDVSETCFAVPTDTDDYQAVGIGPGLGRNEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     CDS             complement(5993..6826)
                     /locus_tag="ctg69_7"
                     /transl_table=11
                     /translation="MTTKKLTGILSLFLCIICLVSCNDNDDNFSPITLEYEDPQIKFDN
                     ESRSYTLTPFSKETTPLFIKGGDGTYKVTNENEKVVQVNYHNGSLTLKAKEIGRASIKI
                     EDSSNNMYILSVVVKYRTLTHKAFTAKVIVKGDELTSEEHTELMNKVGNSYPINKYVFT
                     FMNAEDSKGTVDLYYSDNNMKTGNFEKEHIVLDEENAIPIKGEYKLSEYYRITIKEDNG
                     KVIDTFYITKNFLPLLNTRMNAHPLIQYCFVRDLTAQYKQDYLALENAYLIQIAE"
     CDS             7099..7323
                     /locus_tag="ctg69_8"
                     /transl_table=11
                     /translation="MMEKKRIGSNAGKVWRILNEKGEQSMFTLCHELGLTFEDVAIAIG
                     WLARENKILLRKKEGMLYASIENVEFTFG"
     CDS             7516..9060
                     /locus_tag="ctg69_9"
                     /transl_table=11
                     /translation="MSSLKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASSLNNTD
                     LAHWLMYGGLGFMILGNGCFKPTVSSLVGQLYEPGDKRLDAAYTIFYMGVNVGSFAAPL
                     ICGFLGDTGNPQDFKWGFLASGIMTLFTVVLFETQKNKYLFSPSGEPIGIVPDARREKK
                     EDKAEHILHPKMDKRTKVRNIIIITALTVALIAFFSYAFSDDWISVGIFTACIVFPVLI
                     LLDGSLTKVERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTDRSIFGWEMPASW
                     FQSFNPLFVVILAYIMPGIWGFLNKRNMEPASPTKQAIGLLLLSLGYLFICFGVKDAIP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEDGKVKSILGYQIATMYDFFMLFVIMSGVASLILFLLSKKLQKMMHGVE"
     CDS             9102..9638
                     /locus_tag="ctg69_10"
                     /transl_table=11
                     /translation="MDTIQIKDKQFTVSIKEQDIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGVTSTGVIKEVIGLNEDIAGRTVVIVEDI
                     VDTGLTMQRLLDTLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             9672..10241
                     /locus_tag="ctg69_11"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMLDLEVPEDELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTSPLIDWYKNE
                     KKYQHINGLGTMDGIFADICEAVDKL"
     CDS             10254..11420
                     /locus_tag="ctg69_12"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKNRSFGKDGADKVIEVPCGTVVYNAET
                     GEYLCDVTDDGQEVILLKGGRGGQGNSHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSAISAAKPKIADYPFTTLEPNLGIVSYRDGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     ITKSDMLDQELMDEIEPTLPEGVPHIFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEELDYEYEEDADDDDDDLDYEYEEEDWEEK"
     CDS             11444..12229
                     /locus_tag="ctg69_13"
                     /transl_table=11
                     /translation="MLGYESLSSYSNISHFVTTRQGGCSEGNYASFNCTPYSGDEAEKV
                     RRNQTLLMEGMSQTPEELVIPVQTHEANCLLIGDAYLSASSQQRQEMLHGVDALITREL
                     GYCLCISTADCVPVLIYDKKHSAIAAIHAGWRGTVAYIVRDTLLRMEKEFGTSGEDVIA
                     CIGPSISLASFEVGEEVYEAFQKNGFDMPRISIRKEETGKHHIDLWEANRMQILAFGVP
                     SGQVELARICTYIHHDEFFSARRLGIKSGRILSGIMIHK"
ORIGIN
        1 tgaaataatt aaaaaattaa gcttgaaata tccaaaaaaa aatgcttact ttgcagacca
       61 aatcagattt ttggagaaat tgattattaa cgctaattca aaataactaa aaatgtactt
      121 attattcatt atcttaatgg tgattgcagc cttgctgatg tgcttcatcg tgctgattca
      181 gaattcaaaa ggaggcggac ttgcttctgg tttttcttca tcaaacgcta tcatgggcgt
      241 gcgcaagact acagattttc tggaaaaagc aacttggggt ctggctatct tcatggttgt
      301 gatgagcgtt gctactgctt acgttgttcc ttcttcttct gcggctaaag atgtattgtt
      361 ggaacaagca cagaaagaac aacaaaccaa cccgtataat atgcctaccg gtactgctgc
      421 tcctcagaca gatgctactg ctcctgcaga gtctgcacca gcaacggaag cttcggctac
      481 tgaaactcct gctcctgcag cagaataatt cagtgacagg atattcggtt taaacttatt
      541 gagtgaacgg gctttttgac ccgttctctt cattataggc gcgaattacg cgaattacaa
      601 gagattctaa tagaatcgtg taatacgtgt agttcgcgcc tgtctttatt attgggcccg
      661 gtctgctctt cttcatacag gaatatccgg tcagatgtcc tttttcttat aaaatgttct
      721 ccttttttag taaaacaaat gataattagt taactttgtt gcccgttacg agattattaa
      781 ctccttttaa atattacaat gacagaacaa ttgaaacaaa agctgaatga ctccgcagtg
      841 ctgcgttgga gtgttctagc attagtcgct tttaccatgt tgtgcggcta cttcctcaca
      901 gacgttatgt ctcctctgaa acccatgctt gaaaaagaac ttctctggga cagtttagat
      961 tacggttttt tcaccagtgc ttatggctgg tttaatgtat tcctgctgat gctcatcttt
     1021 ggtggtatca ttctggataa gatgggagta cgcttcaccg gaatgggtgc ctgtttattg
     1081 atggtgttcg gttgtggatt gaaatattat gctattacta ctactttccc ggaaggtgcg
     1141 atgcttttcg gattcaagat gcaagtcaca ttggctgcat tgggttatgc tattttcggt
     1201 gtaggagtcg aaattgcggg tatcaccgtt tcgaagatta tcgtgaagtg gtttaaaggc
     1261 aaagagatgg ctctcgctat gggactggaa atggcgaccg cgcgtattgg aacgactttg
     1321 gccatggtgc ttaccgttcc tttggcagac ttcttcgggt ctacggatga gagcggcgta
     1381 ttccatacca atattcccgc tcctattctg ttctgtctcg tcatgttgtg cgtaggtacc
     1441 atcgcattct tcatctatac tttctacgat aagaaactgg atgcttcact ggatgcggaa
     1501 ggactggaac cggaagaacc tttccgcatg aaagacattg tctatatcat taccaacaaa
     1561 ggattctggc tgatcgcatt actgtgcgta ttgttctatt cggctgtatt ccccttcatc
     1621 aagtatgcgg ccgatttgat ggtacagaag tacaatgttg atccgaaact tgcgggaacg
     1681 attcccggat tgctgccgat tggcgcgatc atcctgacac cgttgttcgg ttcattatat
     1741 gaccgtatcg gtaagggagc cacgctgatg gtgatcgggt cggtgatgct gattttcgta
     1801 cacacgatgt tcgctcttcc tattctgaat atatggtggt ttgcaacggt gatcatgatt
     1861 attctgggat ttgctttctc attggttcct tcggcaatgt ggccttcggt tccgaagatt
     1921 attccggaga aacagttggg aacggcttat gcgttgatct tttgggtaca gaactgggga
     1981 ttgatgggcg tgcctttgct gatcggatgg gtgttgaatt cttattgcaa aggtccggtt
     2041 gtagatggtg cacagactta tgattatact ttgccgatgg ctatttttgc tatgttcggt
     2101 gtacttgccc tgattgttgc cttgatgctg aaagtggaaa acaagaagaa aggctacgga
     2161 ctggaagaag caaatattca gaaataatca cagtatatat tctatctgaa aagatataaa
     2221 agagaaaaga tatggctacg aaagagaaaa taaacctcct ggaggtgatc ccttgtcgta
     2281 acgaacatat taaagctgaa caggaagggg agactattgt gctctccttc cctcgtttta
     2341 aacgttcgtg gatgagtcgt tatttattgc cgaaaggaat gtccaaagat attcatgtgc
     2401 gtctggaaga acacggtacg gctgtatgga acctgataga cgggcagcgg acggttcgtg
     2461 agattataga aaaactcgca gaccactttc aatatgaagc aggctacgag tctcgtgtat
     2521 ctacctatct ttcccaatta cagaaagacg gatttattaa atggataatt atccattaaa
     2581 aaagattgcc cacaggagga cagcacatcc tatcagtacg cccataatga tgagcgttcc
     2641 ccatacgaaa tagttgttat ctttttcttt tttcttttcc gaatccttga tgatgcgttc
     2701 catctcttcc ggagtcgtat ccggcagaag ataagggtcg ttgtttcttc taagtcgccc
     2761 taacttgtca tttctccgtt cacggcgtaa gcgggaggct tctttgccgt ctttcagccg
     2821 acgtatcatg tcgagcatat gtccttcgcc acccatcgtt ttgttttttt agaggtttta
     2881 tttgctttct tctctatcta ctttcagtag tccaccggtc accggatcaa agtaaacttt
     2941 gatggtcgag ttcttgttga ataataccgg agcaaggtat tctatgatac cgaactgagt
     3001 aacaggtatt tctccttcat acaatttctt tttgccgtcc gtcagcgtca ccattgcctg
     3061 tcccggtacg ttataagcaa tgccttccat ctctttcttc tttttcccgt cctcttgcgg
     3121 aatcttcacc gttttcaggt ctttcagact gatgtagaat ggagtgcctg ccaaatcgtt
     3181 gttggcaact atacccagct tctttgaaaa gcggaaagct acctcattgt cgaattcctt
     3241 atccggagtg aggcggacag taaatgtctt ttcttcttta ttgcggactc ccgaaaacat
     3301 ctcggtcatg gcttcttcct gaagattcag gttgtcgagc atgattttga gctgtgcgcc
     3361 gtccgaaggc atattatctg cttgtccgcg caataatgcg tttttacttt cgcggatatt
     3421 atagatttcc tttgctacca gttcggccat cttggcggtt gaacttgcca tcagaatttc
     3481 ttctgtgaga aagtcgcggg gattggcttt tcgttgggga gcaacggcat tgtttgctgc
     3541 attctttgca ttgttactgc tgtaggggac attgattgat ttgataagac cctcttcagt
     3601 cagttccata agaggagcta cggttttgtc tttcagtttg acgaaataag tagcttcgct
     3661 gtttggtaca cctacaggtt tcactttgac actgttcagt tcccagtatt cttcgggttc
     3721 ggcagagacg ttggtcagtc tcaggtagcg gtcggcgtat ttgctgaatt cacccggctt
     3781 atagttgact ttgtttgctt ttatttctat ttctatctgg gttttgggga gggcgtacac
     3841 tactccgtag tcttttcctc gcgtcactcc tgtcagcact tcggtctgcg cataggcgga
     3901 agttgccatt agtagtcctg ttgctatgat taactttttc atattcggtt ctttttagct
     3961 gattttgaaa aacaaagtta atgaagttat tgaataaacc gtaagttctt aacttttatt
     4021 cgcttacaag tcgccatgcc gtcggcagac aagtcacgat atcacttgcg attaatccga
     4081 tcatgccctg ttttttctgg gcgatgtctc cggccaatcc gtgaatgtaa gtaccgatct
     4141 ttgcggcgtc ttcggcggga tagccttgcg caaggagtgc aaggattact cctgtcagta
     4201 catctccgct gcctcctgtt gccataccgg gattaccggt ctggttgaag taacatttgc
     4261 cttcgggggt gataatggcg gaataagctc ccttcagaat gatatgtact ttggcagtgt
     4321 gcgccagttc gcaggctttc atcagtcgtt cgtatgagtc ctgacatttg ccgaccaggc
     4381 gttccagctc tttcgggtga ggggtgagga tggaaccttt cggcagatgg gtgagcgtat
     4441 gccggtgatt ggccagaata ttgagtgcgt cggcatccag taccgtcgga gtctgacaat
     4501 gttccagttg ttctatcagg gcggcttccg tttcttcgtt gcgaccgagt cccggaccga
     4561 tgccgacagc ttggtaatcg tccgtatcgg taggtacggc aaagcatgtt tcgctgacat
     4621 ctgtttctac catggcttcg ggggcggacg tttgcagaat atcgttgttg cataacggcg
     4681 cgtgtaccgt cagcagacct actcccgatc gcaaacaggc acgggcggcc agtaccgatg
     4741 cacctgccat tccttttgag ccggctatca gcagggcatg tccgaagttt cctttatggg
     4801 cgaattgttg gcgtggtttg atcagtgaac ggatttcttc gatttccagc atttcgtagt
     4861 ttgtttcagt ctcttcgatt ccttcttcgc tcagctggat gtccaataac tcccattcgc
     4921 caacaaattc tgtattttcg gcaaagagga aggccagttt aggaagttgc aggctgaaag
     4981 tgacgtccgc acggataata ttgcttttta cattgaatgt attttcttct cccatcagcc
     5041 cggaagggat gtcgatggag actaccatgg cgggagaggc attgatatat ttcacaacgg
     5101 cagcgaatcc tccgctcaat ggtttgttga gtccggaacc gaataatccg tcgatcacga
     5161 gatgttccgg tgtcagtgtg ggaggtacga actgggtgct gatttcatgg aaagttactt
     5221 cttccatcat ctctaccagt tctttgttgg tctggcagtc gggcgaaagt tcgcctttcg
     5281 tgttgaagag atatacttcg atcttgtatc ctttttccgc catcatgcgg gcgatggcga
     5341 gggcgtctcc gccattattg cccggtccgg caaagatggt gacaggtgtt tccggattcc
     5401 atctgttggt gatggcttta gtcagtgcct gtgcggcacg ttccattaaa tctatggatg
     5461 caatcggttc atgttcaatg gtataggcat ctaacttctt aatgctgctg cttggaaata
     5521 ttttcattgc gatattcttt tagttttcga cgcacaaact tacacaaaaa ctctgaatta
     5581 atcctttatt ccggttggtt ttcggctttt tgggaaggaa cttcaggtat taatacttga
     5641 gttgtcaggt attaatagtt gatgtgtcag ttattaatag ttgagaagtc agatattaat
     5701 gattgttatc tcatttactt ttactctctc cggagaacat tcatggctgt ttgttaacct
     5761 tcccatgcgt gtttctacta ctgtatattc ctctggttca cctctttcac ccgcaatcgc
     5821 cttattcatc aaaggttcag gaaaagggtg gaagaggtga ttgtgataaa tatgctatgg
     5881 gcatattctt gattagctaa tagcttattg ttttttgcta aatctaatgg ggagtttgct
     5941 catataataa atactctatt cactctgcta aagaagaaaa tcagtgtagc tctcattctg
     6001 ctatttgaat cagatatgca ttttccagtg caaggtaatc ttgtttgtac tgtgcggtta
     6061 aatctctgac aaaacagtac tgaattaacg gatgagcatt cattcttgta ttgaggagtg
     6121 gtagaaagtt cttggtaata tagaaagtat caataacttt gccattatct tctttgattg
     6181 ttatacggta atactcactc aatttgtatt cacctttgat gggaatggca ttttcttcat
     6241 ccagcactat atgttctttt tcaaagttgc ctgttttcat gttattatct gaataataca
     6301 aatctactgt tcctttgctg tcttccgcat tcataaaagt aaatacatat ttattaatcg
     6361 gatatgaatt gcccactttg ttcattaact cagtgtgttc ttcagatgta agctcgtctc
     6421 ccttcacaat gacttttgct gtaaacgcct tatgagtaag agtacgatat tttacaacga
     6481 cagacagtat atacatatta ttcgaactgt cttctatctt gatggatgcg cgtcctattt
     6541 cctttgcctt caatgttaaa cttccgttgt ggtagtttac ttgtaccact ttctcattct
     6601 cattggtcac tttgtaagtt ccgtctccac ccttgatgaa gagtggtgtc gtttctttgc
     6661 tgaacggagt cagtgtgtaa gaacggctct cgttgtcgaa cttaatttga ggatcttcat
     6721 attccagagt gattggagaa aagttgtcat cattgtcatt acagctcacg aggcaaataa
     6781 tacaaaggaa taacgaaagt attcctgtta gttttttggt agtcatgcta attaaagttt
     6841 taaatgtgcg atattagttt agttctcgtc tgcaaactta tgaaaaagaa ttgaactgtt
     6901 tctttatttg tgctattttt tagcagagat cggcataaat gattagaatg taactaataa
     6961 tagcagctaa tgctttgatt atttgctttt ttcgaaaaaa atgatatctt tgtagtgcag
     7021 taatgtgctt tacgttattc tcctgtgctc acaatgttta gattataaat ataaattgtt
     7081 taatcttcta aagtttgcat gatggaaaag aaaagaattg gctcaaatgc cgggaaagta
     7141 tggcgcatct taaatgaaaa gggcgaacag tctatgttca ctttgtgcca tgagttaggt
     7201 ttgacgttcg aggatgtagc gattgctatc ggttggctgg caagggaaaa caaaatcctg
     7261 cttagaaaaa aagaaggaat gctctatgcc agtattgaga atgttgaatt tacctttgga
     7321 taaatgggga ctgacccaca tttaaggaga atatccactt gattatttac actgttgaaa
     7381 acataataag gtgggtaact gagacttctt gcacgccatc ctgtattttt ctattccata
     7441 agaatcttct tttttgaggc atttaatcta ctttttagta cctttgcgcc ccataaacta
     7501 ctaaacacat aattcatgag ttcattgaaa gggcacccga aaggccttta cctaattttc
     7561 gcaacgagca cggcagaacg tttcagttac tacggtatgc gtgctatctt tatcctcttt
     7621 ctgacgcagg cattgctttt tgataaagaa gcggcggcct ctatctacgg tagctacacc
     7681 ggactggtct atctgactcc gttgatcggc ggatacattg ccgataaata ttggggtatc
     7741 cgtcgttcgg tattttgggg agcggtgatg atggcagtcg gtcagttcct gatgtttatg
     7801 agtgcctctt cactgaacaa tacagacctt gcccactggc tgatgtatgg cgggctcgga
     7861 ttcatgattt taggtaacgg ttgctttaag cctaccgttt cttcgctcgt cgggcaatta
     7921 tatgaacccg gggacaaacg gttggatgct gcatacacca ttttctatat gggtgttaat
     7981 gtaggttctt tcgccgctcc tttgatttgc ggtttcttgg gagacacagg gaatccgcag
     8041 gactttaaat ggggattcct cgcatccgga atcatgacgc tgttcactgt tgtcctcttt
     8101 gaaactcaga agaataaata ccttttctct ccttccggtg aaccgattgg tatcgtcccc
     8161 gacgccagac gtgaaaaaaa ggaggataaa gccgaacata ttttacatcc gaagatggac
     8221 aaacgtacca aagtacgtaa tatcatcatc attactgccc ttacggttgc cttaatagcc
     8281 ttttttagct atgcctttag cgatgactgg attagtgtgg gtatctttac ggcttgtatt
     8341 gtctttccag tgctcattct gctggatggt tcattgacca aagtagaacg tagccgtatt
     8401 ttcgtaatct atatcgtagc tttcttcgtc attttcttct gggcagctta cgagcaggca
     8461 ggagcttctc tgacattatt cgcttccgaa cagactgacc gcagcatttt cggctgggag
     8521 atgccggctt cgtggttcca gtcattcaat ccgctttttg tagtgatcct tgcctatatt
     8581 atgcccggta tatggggctt tctgaataag cgaaacatgg aaccggcttc ccctaccaaa
     8641 caggcaatcg gtctgttgct gctttctctt ggttatctct tcatctgttt tggagtgaaa
     8701 gatgctattc caggagtaaa ggtgagcatg atctggctga cagggcttta ctttattcat
     8761 acaatgggag aaatcgctct gtcacctatc gggctttcta tggttaataa gttgagtccg
     8821 ttacgtttcg cctccttgat gatggggatc tggtatcttt ctaccgccac cgcaaataaa
     8881 tttgcaggta tgctgagcgg cctctatccc gaagacggaa aagtgaaatc aatccttggt
     8941 tatcagatcg ctaccatgta cgacttcttc atgctgttcg tcattatgtc cggtgttgcc
     9001 tcactgattc tgttccttct ctcgaagaaa ttacagaaga tgatgcacgg ggtagaataa
     9061 aaaattgtat ttttgcgaca acttttttaa aatgaccggt tatggatacc atacagataa
     9121 aagacaagca atttactgtt tccattaagg aacaggatat tcaaaaagaa gtgattcgcg
     9181 tagcgaacga aatcaatcgt gatttggcag gtaagaatcc gctcttcctc agtgtgttga
     9241 acggctcgtt catgtttacc gccgacttgc tgaagcatat tacgattccg tgcgaaattt
     9301 cattcgtgaa gttggcatct tatcaggggg tgacttccac cggagtaatt aaagaagtga
     9361 tcgggctgaa tgaagacatt gccggacgta cggtagtgat cgtagaagat attgtagata
     9421 ccggactgac gatgcagcgt ctgctggata cactgggcac acgcaacccc gaagcgattc
     9481 atatcgcctc tttgctggtg aaaccggaaa agctgaaggt caatctgaac atagaatacg
     9541 tagcgatgga aataccgaat gattttatcg ttggctacgg attggattat gatggtttcg
     9601 gacgcaatta tcccgatatt tatactgtag tagattaaat tcaaatacaa attaattttt
     9661 aggttaaaaa gatgttgaac attgtaattt tcggtgctcc gggttcagga aaaggaacgc
     9721 agagcgaacg tattgtagaa aagtatggaa tcaaccacat ctcgacagga gatgtattgc
     9781 gtgcagaaat caagaacggc acggaactgg gcaaaactgc taaaggttac atcgaccagg
     9841 gacagttgat tccggatgaa ttgatgattg atattctggc aagcgtattc gatagcttca
     9901 aagacagcaa aggtgtaatt ttcgacggtt tcccaagaac aattgcacag gcggaagcat
     9961 taaagaagat gttggcggaa agaggacagg atgtttctgt aatgttggat ctcgaagttc
    10021 cggaagatga actgatggta cgtctgatca aacgtggcaa agactccggt cgtgccgacg
    10081 acaacgaaga aacaatcaaa aaacgtctgc atgtatatca ttcacagaca tctccgctga
    10141 tcgactggta caagaacgaa aagaaatacc agcatatcaa cggtctgggt actatggatg
    10201 gtatcttcgc tgatatctgc gaagcagtag acaaattgta ataaataaaa aatatggctg
    10261 aatcgaattt tgttgattac gtaaagatat actgtcgctc aggcaagggc ggaagaggct
    10321 ctacgcacat gaggcgcgag aaatattgtc ctaacggagg tcccgatggg ggcgatggtg
    10381 gaagaggagg ccatattatc ttgcgcggta accgtaatta ctggacattg cttcacttga
    10441 agtatgaccg tcatgcgatg gcaggtcatg gcgaatcggg cagcaagaac cgtagtttcg
    10501 gaaaagacgg tgcggataaa gtgatcgaag taccctgcgg aacggtagtg tataacgccg
    10561 aaaccggaga atacctttgc gatgtgacgg acgacggaca ggaagtgatc ttgctgaaag
    10621 gcggtcgtgg cggtcagggc aacagtcatt tcaagacggc tacccgtcag gctccgcgct
    10681 ttgcgcagcc gggcgaaccg atgcaggaaa tgacggtgat catggagctg aaactgttgg
    10741 cagatgtagg actggtaggt ttcccgaatg cgggaaagtc tacgttgctt tctgccattt
    10801 cggctgcgaa accgaagatt gccgattacc cgtttacgac actcgaaccg aatctgggaa
    10861 ttgtttccta tcgcgatgga aagtcattcg tgatggcgga cataccgggc atcatcgagg
    10921 gagccagtca gggaaaagga ttgggactgc ggtttctgcg tcatatcgag cgtaactcgt
    10981 tgctgttgtt catggttccg gcagatagcg atgatatccg caaggagtat gaagtattgc
    11041 tgaatgagct gcgtacgttc aatcccgaaa tgctggacaa acaacgtgtg ctggctatca
    11101 cgaagagcga tatgctcgat caggagctga tggacgagat tgaaccgaca ttgcccgagg
    11161 gtgttccgca tatattcatt tcttctgttt ccggtttggg aatctcagtg ttgaaagaca
    11221 ttctgtggga ggaactgaac aaggaaagta ataagataga agacattgtt caccgtccga
    11281 aagacgtgac ccgtctgcaa caggaactca aggacatggg cgaggatgaa gaactcgact
    11341 atgaatatga ggaagacgct gacgacgacg atgatgatct cgactacgaa tacgaagaag
    11401 aggattggga agaaaaatga tttcaatcac aagagataaa agaatgttgg ggtatgagtc
    11461 gttaagctca tactccaaca tttctcattt tgtaactacc cggcagggag ggtgcagcga
    11521 aggaaattat gcgtcattca actgtacgcc ctacagtgga gacgaggcgg aaaaggtccg
    11581 gcggaatcaa acgcttctga tggaaggaat gtcgcagaca cccgaagaac tggtgattcc
    11641 tgtgcagact catgaggcga attgcctgct gatcggggat gcttatttat cggcttcgtc
    11701 tcaacaacga caggagatgc tgcacggagt ggatgctttg attacccgcg agttgggata
    11761 ttgcctttgc atttctactg cagattgtgt tcctgtgttg atatatgata agaaacatag
    11821 tgccatagct gccattcatg ccggatggag agggacggta gcatacatcg tgcgtgatac
    11881 tttgttgcgg atggagaagg agtttggcac aagtggagaa gatgtgatag cctgtatcgg
    11941 tccgagtatc tcattggctt cttttgaagt gggtgaggaa gtgtacgaag catttcagaa
    12001 gaatggtttt gatatgcctc gtatttctat caggaaagag gaaaccggaa aacatcatat
    12061 cgacttgtgg gaagcgaacc ggatgcaaat ccttgctttc ggtgtgccgt ccggacaagt
    12121 ggagcttgcc cggatatgta cgtatattca tcacgacgag tttttctcgg caaggcgttt
    12181 gggcattaag tccggacgga ttctgtcggg gatcatgatt cataaataat agacttgaac
    12241 gtaagttgat ataaacttga ataaaagtat gtttgaaata aaagtatctc aggaaataaa
    12301 gaacgcctgc cctgtttttg ccggagcagc cgtatatgca gcagtgaaga atactgctta
    12361 ttgcgatgga ctttggaaag aaataaatat tttcacagaa gacttgacta ccaccaccca
    12421 aatggcagac attaagttgc aacctgtgat tgctgctacc cgtgaggctt ataagcgttg
    12481 cggaaaagat ccggggcgtt atcgtccgtc ggcagaagcg ctgcgccgtc gcctgatgcg
    12541 tggcatccct ttgtatcaga ttgatacttt ggttgacct
//
