LOCUS       gnlProkkaPDLMHNFB_9    12458 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PDLMHNFB_9.
ACCESSION   gnlProkkaPDLMHNFB_9
VERSION     gnlProkkaPDLMHNFB_9
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:11:46
            Original ID  :: gnl|Prokka|PDLMHNFB_9
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12458
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12458
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3144:7458]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3145..7458
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12458
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12458
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..1922
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="MISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTT
                     DPTSDIRLTLGNIRTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQL
                     VRNGKNIATIDVYEFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKD
                     ENLATLIKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAIL
                     NRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSE
                     VVQIDIKSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTL
                     EDLIIQAGGLKEAASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFIL
                     EPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRG
                     AKLTRVANASEKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNA
                     DLVLREGDVISIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKF
                     IVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIAN
                     LIKK"
     CDS             1933..3081
                     /locus_tag="ctg9_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3145..3864
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 8.8e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3885..5186
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_4"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.1e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5203..5856
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     65.9, seeds: 75, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEY"
     CDS             5860..6327
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.9e-19, bitscore:
                     62.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEQGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFI
                     MHLGAISNIGDLSPKNYYHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCT
                     KVEIEEAMKQLPKLCGPVLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6337..7458
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg9_7_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_7"
                     /sec_met_domain="Aminotran_5 (E-value: 8.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6427..7434
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg9_7_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg9_7_Aminotran_5.1"
                     /locus_tag="ctg9_7"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7455..7598
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             7801..9285
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_9"
                     /sec_met_domain="Polysacc_synt (E-value: 7.4e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFLLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9239..10498
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             10507..11256
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11256..12296
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 agcaaatctc tcctgaaggt actatcaaca ttcagaagat cggccctgtc aaccttagcg
       61 gtatgacagt ctctgccgcc aatgactatc tgaagaacgc cctgaataaa atatataacg
      121 gtctgaataa tactaccgat cctacttccg acatccgtct gacgttaggt aatatccgta
      181 ctatccagat taatgtgatg ggagaagtcg tacagcccgg tacctacgcc ctttcttcct
      241 tctctaccgt cttccatgcg ctttatcgtg caggcggtgt gagtgatatc ggtagcctcc
      301 gaaacgttca gttggtacgc aacggaaaga atattgccac catcgacgtc tacgaattca
      361 ttatgaaagg caacacacag gatgacatcc gcctacagga aggtgacgtt gtgattgttc
      421 ctgcctatga tgtattggta aagattagcg gcaaggtaaa acgtcctatg cgttttgaaa
      481 tgaagaaaga cgagaacctt gctactctca ttaaatatgc cggcggcttt gaagctgatg
      541 cctacacccg ttcattacgt gttgtccgtc agaatggtga ggaatacgaa gtcaacacag
      601 tcaaagatat agattacaac atttataaaa tgcgtaacgg tgacgtagta accgccgaag
      661 ccatccttaa ccgcttcaca aacaaactgg aaatccgtgg cgctgtctat cgtcccggta
      721 tctaccagct cagcggtaaa ctgaacacga tccgcgaact tgtccatgaa gctcagggtc
      781 tgaccggtga cgctttcctg aatcgtgccg tcctctatcg ccagcgtgaa gacctgacca
      841 gtgaagttgt tcagatagac attaagtcta tcatggacgg cacttcccca aaccttgccc
      901 taatgaagaa tgacatcctc tacattccaa gtatccatga cctggaagac cggggtaatg
      961 tcacagttca cggtgaggtt gcccaccctg attcctatcc ttatgcggat aacatgacac
     1021 ttgaggatct gatcattcag gccggtggct tgaaagaagc cgcctctact gtccgtattg
     1081 atatatcgag acgaatcaag aatcctcgta gtactgcgga taatgatacg attggtcaga
     1141 tgtatacctt ctctttaaag gatggttttg taatagatgg tcagcccggt tttatccttg
     1201 agccttatga tcaggtttat gtccgtcgca gtccgggcta tcaggcacaa cagaatgtag
     1261 ccattgaagg tgaaatcctt ttcggaggaa attacgccat gaccagccgt gaggaacgtc
     1321 tttccgattt agtgaataaa gccggtggtc cgaccaatta tgcctatctg cgtggtgcga
     1381 aactgacccg tgtggctaac gctagtgaaa agaaacgtat gggtgatgta attcgcctta
     1441 tgagcaggca attgggcgaa gccatgattg actctttggg tattcgtgtt gaagatactt
     1501 ttacggttgg aatagatttg gaaaaagcct tgagcaatcc taaaagtaat gccgatcttg
     1561 tcttacgtga aggtgatgtg atctccatac ctaagaatac taatactgta actatcaatg
     1621 gtgctgtcat ggttccgaat acggtttctt atatgaaggg aaagaatgtg gattattacc
     1681 tgaatcaggc cggtggctgt tctgataatg caaggaagag taagaagttc attgtttaca
     1741 tgaatggtca ggtgacgaag gttaagggta gtggtaagaa acagattgag ccggggtgtg
     1801 agattattgt gcctggtaag gctaagaaga aagggaacat agctaatatt ttaggttatg
     1861 ctacttcctt cagttctttg ggaatgatga ttgcttctat tgctaatttg ataaagaaat
     1921 aaatgaccta ttatgattga aaagcaatct tatcaagaac cgttttctga agtggataaa
     1981 aggaaagatg atgaaatgga aatagacttg atggctattt tttataagat tattactgtt
     2041 cgtggagtac tatgcaaagc tgctggagtg ggagtaataa ttgctatagt ggtggcattg
     2101 agcattccca agcaatatac agtaaaggtt accctttctc ctgaaatggg taatgcgaag
     2161 ggaagtaatg gtttagccgg acttgctgcc tcgtttttgg gagatggggc tctaataggg
     2221 gaaagcacag atgccttgaa cgcttctctt tcagcagata ttgtttcttc aactcctttt
     2281 ttattggaac ttttagaaat ggaagtctcc gtttctaaaa aggatgataa aatgactttg
     2341 gggtcttatc tcgatgaaga gtcatctcct tggtgggatt atcttatagg ttttccgggc
     2401 atagtaatag gaggagttaa atcattattc ggagaagata cggttcctgc cagtggaggg
     2461 cggcaaggaa ctatcgaatt gacgaaagaa gtaaatgaga agattaattt tcttaaaaag
     2521 aagattagtg catccattga taagaaaacc gccataacga gcattacggt caccttacaa
     2581 aatccgcaga tcactgcggt tatagcagat tctgtcgttc ataaattaca ggaatatatt
     2641 attgggtatc gaacttcaaa agtaaaagaa gactgtgcgt atttggaacg gttgtttaaa
     2701 gaacgtcagc aggaatatta tgctgctcaa agaaaatatg cggattatgt agacgcccat
     2761 gataatgtgg ttcttcaaag tgtacgtgct gagcaggagc gtttacagaa cgacatgagt
     2821 ttggcttatc agatatatag tcaggttgct aatcagttgc aggtatccag agccaaagta
     2881 caggaggaaa agccagtctt tgcagtagtt gagcctgccg ttgtaccttt gaaaccttca
     2941 ggtatgggac tcaaaattta tattttatta tttgtgttcc tgtccgtatc tggtactctc
     3001 gtgtgggtgt tttttggcaa aagtctgctg gctagcttga gaaaagaact gaaaaataag
     3061 gagatagaac aggataaatg atgctaaaac gtcgtttaca acattcttac atcaattaaa
     3121 ttcacttact atattattaa acgaatgata cgtacagcta tgataatggc tgcgggcatg
     3181 ggaacccgtt ttggccaata tacagaattg atacctaaag ggttcgtcaa agtgggaggt
     3241 attccaatga tagttcgttc tattgatact ttgttatcat gtgacattga gcgaattgta
     3301 atcggtacag gatataaaca agaagtttat gaagaattga agacagacta tcctatgctt
     3361 gaaacctgtt ttagtcctcg ttatgctgaa acaaatagta tgtatacttt atataatacg
     3421 cgggagattc tgggcaatga tgatttttta ttgttagagt cagatttgat ttttgagaaa
     3481 caagcaataa tgagcttatt ggagtgtcct gcggcagatg caatgctaat aactccagtg
     3541 acaaagtttc aagatcagta ttatgtggaa catgatgata attttcgcct ttcttcatgt
     3601 tctgtcaata agaataaact aaacgctaaa ggcgaattgg tcggcatcca taaactatcc
     3661 ggttcctttt acaaaataat gtgtgctgat tatgcgagta ttgttgatga acaacccaat
     3721 ttgggatatg agtatgaatt actacgaata tcttgttctc aatctcctgt ttatgtgcat
     3781 aaagtagaag ggctgaaatg gtatgaaatc gatgacatat cagatttgga atatgcagag
     3841 aaatatattg ttccgtattg ttaattaaaa taatatatca aattatgagt aagacagttt
     3901 atattgggat gactgcggat attatgcatc caggacttat ccgcattatt aatgaggcta
     3961 ctaaatacgg tgatgttata attggtcttc ttacagataa agctattgcg gagcataaac
     4021 gccttcctta tctgacctat gaacaacgaa aagaggtagt tcagaatatt aaaggcgtat
     4081 gtaaagttgt tcctcaagaa gaatggagct atgttgagaa tctcaaacgc attaaacctg
     4141 actatataat tcatggtgac gactggaaaa ccgggccttt acgtgaagaa cgtgtgcgcg
     4201 tatttgaagt gatgaatgaa cagggaggaa aggttatcga aattccatat actttgggaa
     4261 ttaattcatc ttctttggat aaagatatta aggctatagg tacaacccct gatgtacgtt
     4321 taaaatcact tcgtcgtttg ataaatgcca aacccgtagt tcgtattttg gaagctcatg
     4381 atggactatg tggcttgata attgaaaatc aggaaatatt aaaaggggat aagagggaag
     4441 tatttgacgg aatgtggtct agtagcctta cggattcaac cagtaaaggt aaacctgata
     4501 ttgaggcggt tgatttaact acccgattgc aagatttgaa taatattctg gagtgtacta
     4561 ctaaacctat tatttttgat ggagatacag gtggtaaaat tgaacatttc gtatttacag
     4621 tacgcacttt agaacgtcat ggaatttcag ctataataat tgaagataaa gttggattaa
     4681 aaaagaattc attgtttggt acagatgtta ttcaaactca agatacaatc gaaggtttct
     4741 gtaataagat caaagcagga aaggcatctc agattactga tgattttatg attatcgctc
     4801 gtattgagag ccttatagcg ggaaagccgg taagtgatgc tttagagaga gcttttgcat
     4861 atgtccaagc gggagcggac ggtattatga tacatagcaa aaataagtcg ggtgaagata
     4921 taaaagaatt ttgtttggcg tttcgaaaac agtatgctca tgtacctatc gtggttgtgc
     4981 ctactacata tgatcatatt tatgagtctg aattgtgtga ttggggtgtg aatataatta
     5041 tttatgctaa tcatatgctt cgtgccgctt atcctgctat gatgaatgtc gcaaagataa
     5101 tattagagaa tgaacgtgct ttagaggtgc gcgaactgtg tatgcccata aaagaaatat
     5161 tggaactgat tccaggtact aaataaaaag aggaatatca ttatgttaag cgtagaaaaa
     5221 gtttatgaaa cgtttctgag tcatgacgtt gattttttta caggagttcc agactcatta
     5281 ctaaaaaata tttgtgccta tatcacagac catacttcac gtgagaaaca tatcatagct
     5341 gctaatgaag gtgcggctgt aggaattgct tcaggttatt atatggcatc aggtaaggtt
     5401 cctgtggttt atatgcaaaa ttccggcttg ggtaatactg ttaatcctct gctgtctctt
     5461 gcagatgaac aagtatacag ttttccaatg cttttgatga ttggctggcg tggtgaaccg
     5521 ggaacaaaag atgaacctca gcataaaaaa cagggtgagg taactttaga tttgttgaaa
     5581 gcaatgcgga ttccttatat aattcttgat tcaaatgaga atgatgcatt tattcagctc
     5641 catgatatca tacaatcagc aaaaactaag aatattcctc atgcaataat tattcggaaa
     5701 gatgtttttg gcaaatataa acttcaaaaa gagttcggat gtaattatcc tttatctcgt
     5761 gaggatgctt tgcaaatagt tgtggattat ctgcctgaaa attcagtggt cgtttctact
     5821 actggcaagc tttctcgtga gttatttgaa tattgagaaa tgaaagagca aggtcatgaa
     5881 catgattttc tcacggtagg ctctatggga catagttcat caatctcttt gggtattgct
     5941 atagcaaagc aagatagacc tgtttattgc ttggatggtg atggagcatt tattatgcat
     6001 ttaggggcaa ttagtaacat tggcgattta tctcctaaaa actattatca tattttgttt
     6061 aacaatggtg ctcacgagtc tgtaggagga cagcctactt taggatttag tttagatatt
     6121 ccggctattg tccgggggag cggatataag catacttata ctgtttgtac aaaagttgaa
     6181 attgaagaag caatgaagca gcttccaaag ttatgtggtc ctgttttgtt ggaaataaag
     6241 gttaaaatag attctcggga gaatttggga cgtcccacga ctactcctat agagaataag
     6301 gagcatttta tggatttttt aaaataaata tattcgatga aaatagaaag aaaaatatta
     6361 ttaaatcctg ggcctgccac tactactgac agtgtaaaaa tggcacaagt tgttccggat
     6421 atttgtcctc gcgagaaaga attcgcaggt atgatgaaac aacttcggga cgatttggtc
     6481 agagttgctc atgggaattt ggaaaaacat accgctgtat tattttgtgg ctcaggaacc
     6541 atcaatattg atatatgtct aaattctctt cttcctgaag acaaaagggt gcttatagtg
     6601 aataatgggg catatagtac ccgtgctgta gaagtgtgtc aatattatgg tttgcctcat
     6661 attaatttgg aattttccgt ttacgaacgt cctgatttat cggtggtgga aaatgtgttg
     6721 caagaaaatc ctgatatagc tatggtttat actactcatc acgagacggg tacaggaatt
     6781 ctgaacccta ttcgcgagat gggcgctata gctcataaat atcaggctaa atttgtcgtc
     6841 gatactactt cttctttggg catgattcct tttgatatag agaaagataa tgtggatttt
     6901 tgtatggcat ctgctcaaaa aggacttcaa gcgatgacag gtctttcttt tattataggc
     6961 aatgaggaac agattaagtt ttcaaaaaaa tatcccaagc gttcttacta ttgtaatctt
     7021 tatttgcagt atgagaattt tgagagaaca ggtgaaatgc attttactcc accggtacaa
     7081 actatttacg ccactcgtca ggcattaaat gaatattttg aagtgggtga agaagctaag
     7141 tttgcccgtc acaaaagagt ttttgaggct attcattcag gtataaatga aattggtctt
     7201 aaaagtgtaa taaagcgtga atggcagtca ggactggttg tctcagttca atacccagaa
     7261 gatcccaact gggattttga gaaaatacat gattattgtt atgagcgtgg atttacgatt
     7321 tatccaggta agatatcaac tgaggatact tttagaatct gtgctttagg agagatagaa
     7381 gtagatgata ttgagaactt ctttaaagta ctaaaagctg cattaaatca ttataacgtc
     7441 acattaccga tgtcatgatt gcagaaatat tattgaagat tcgtcatttt tatttttccc
     7501 ttcgtggtat acacttccat ccggaaagtg ttatttctgg agtgcctatt cgtagctttc
     7561 gcttagtagg caaatatggc aatattaatt tgaggtgatg cattaggagt tctttattct
     7621 tataaaaagg catcggtagt tataggagat aatgtttgtg tagggtaatt tgcttttagt
     7681 gggagagacc atattagaat tgcggtaagg ggcgaagaag ataataacca attagtgaga
     7741 atattggaaa aatataattg atatcggtaa atgtagttgt ttttatactg tatttaagta
     7801 atggaaaatc taaagcagaa aactgtatca ggaataatgt ggagcgctat agaacgtttc
     7861 tctttacaag gagtacagtt tataattcaa ataatattag ctcgtttgtt actaccatcg
     7921 gattatggta tgatcgggat gttagctatt tttcttcaag tcgctcaagt atttatagat
     7981 agcggtttta caaatgcttt aatccagaaa aaagatagaa ctgaagagga ttttgccact
     8041 gtcttttatt ttaatattct tgtcgcagta ttattctatg gtatattgtt tttttcggct
     8101 tctttgattg cagactttta taatatgccg actttagttc ttgtaattcg ttttatagca
     8161 ttgtcgttga taataaatgc tttatcggct attcacagaa cgaaattaat tatttctgta
     8221 aactttaaaa ctcaatctaa aatttcatta ggtgcagctt ttatatcagg cgtgattgga
     8281 atatggatgg cttatgtcgg ttgcggggtt tgggctttag tttggcaaac tctcttaaat
     8341 agtataattt tgacaatttt gttttactgt ttagttcatt ggaaaccttt acatactttc
     8401 tccaaaagtt cttttgaaag attattcaat ttcggatcta aattattgat ctcaagtctt
     8461 atcaatacag tatatcgtaa tctgtatacc attgtaatag gaaaaaagtt ttctgttgta
     8521 gagcttggtt actatacaag agcagaacaa tttgctattt ttccttccaa taatttaaat
     8581 gctttagttt ctagagtagc gtatcctatt ttaagttcca ttcaagatga tgataaatgt
     8641 ttaacaaacg catatcgaaa ttatatcaga ttatcctcat atataatttt tcttttaatg
     8701 gtaggtttac ttgttttggc taatcctatt attagtctat tgttaacaga taaatggtct
     8761 ggggttgtta ttcttttaca gatattatgt ttggattgga tgtttgatca tttgagccaa
     8821 attaatttga atttattatg ggttaaagga agatctgatc tgtcgttacg tcttgaaata
     8881 ataaaaaaga cgattgctat attcattctt tttgtgtcaa ttccatttgg gcttgaggtg
     8941 atgtgttggg gtagagttat ttactctctg atagcgacat atttgaatac atattatact
     9001 aattctctta ttgatttgac cttaaagttg caagttaaag atgtatttcc aagtttaata
     9061 ctctctttca taatgggggg gatcgttttt atatgtattt ctttctttga aactgatata
     9121 gtaaaaattg tgattggatg tattactggg atgtccttct atattttact ttcttttctt
     9181 tttaagctag attctttttt ttgtatttta acattgatca ttaaaactaa aaacatagat
     9241 gaaaatatta aaaaagattt ttcaagtaat agtaaagata attaaccatt gtgtgccagt
     9301 tgatagtaga tcattgtatt ttattcctca tcctaattgt agaacagata aatatgatat
     9361 tataaattat tcgtcagata atgttctcgt tctgttaaat tatttgctaa aaaaagatag
     9421 tgctgaatat tataaaatat atgttgaaat ttatgattct tctcgtattt cagaatatca
     9481 agaatatatt tatggcataa atcctaatat taggtgtact tttttatgtg catgtgttgg
     9541 acgttttttc tttaataaag tatcttttaa ggatatgttg tatgcctttt tttgtttttg
     9601 tagagcaagt aaatgtttta cagctacttt ttattatgat ttttcattta aaaaacgctc
     9661 tcaacagatt atttgtttgg ggtattatac tccattcaaa gatgattatc atatgggaga
     9721 tcattcttat gataaatttc gtaatacaac atgtaactca tttgattact ctattgctac
     9781 ttcttgttta agtgctagaa taatttcaat agattgtgga atctcatatg ataaattcaa
     9841 agtcttagga tttcccagaa atgatttgtt gatatcgaaa aataattgca atgttattaa
     9901 aagagaaatt tcgaaatttg cgggatatga tgtaactaaa tatatagttt atactccaac
     9961 ttttcgtgat tatgagactg ttactgaagg taatttgcgt tcaatactcg gatatgttga
    10021 ttgtgatttg ttgaagttat cgaaaatact attgaagttt aatgcggctt taattcttaa
    10081 attacatcct ttgcagaata aaacagtctt aaaaaaagat ttacccaaag gtatacttgt
    10141 ttttgaacaa acatataaat atggattgta tgatcttttg tcattttcag atggaatgat
    10201 tactgattat acttctacct attttgattt tttattggta aataagccag tcatatttaa
    10261 tttctacgat attgaagaat atcgtagagt aagaggtttc tcatttgagc caatagaatt
    10321 tttttgtgca ggtgatattg tttacaatta taatgaattg atagatgctg tgatgggact
    10381 tctggctggg aaagatattc atgctgaaca tcgacgtcat atttctttat tgatgaatca
    10441 atttcaagat gataattcaa caaagagaat atgtgacata tttttaaatg aaatataata
    10501 aataaaatga attatgcatt tgtggtgcag gcacgtttag gttctacacg tttgcctgga
    10561 aaaatattga aacctttcta tggtaatcaa tcgattcttg acttaatggt tcataagctt
    10621 tctgctatat cgaatattcc agtaattatt gctacaacaa attctgttat caatgaacct
    10681 attgaaaaga aggcacttgc attaggggta aagtgcttca gaggtgagga gaatgatgtt
    10741 ttaaaacgat tcattgatgt tgctgaatat tttgatatac agggtatatt ccgaatatgt
    10801 tctgataatc catttttaga tgtacatgcg gcaaggcaat tggtcgaaat agcaatgaaa
    10861 tcttgtaacg attatataag ttttgatatt gatggtactc catcaattaa aactcatttc
    10921 ggtttttggg gagaatttgt aacgcttgat gcgctgaagc gagttatagg atttactgat
    10981 gatttattgt atcgtgaaca tgttactaat tatatatata gtcatcctga actttttaat
    11041 attcaatgga tttcaggatc tccagtcgtg tcaaaacatc ataatattcg actcacgatt
    11101 gatacgttag aagatttttc tgtagcacag agaatatata gggatttaca agaaaaaaga
    11161 gtggaaatat cgatagaagt gattgtagac tatgttcgaa gacatgcaga atacattcaa
    11221 ctgatgaaac aacaaataaa aaaaaattct aaataatgaa gaatacttat attattggtg
    11281 aaatagggca gaatcataat ggttctgttg acttggctaa gttgattatt gaattaatct
    11341 cacgacctgt acatgaggat gtttttggta tggatttcat gccaatgaat gctgttaaaa
    11401 tgactaaaag agatttatca gaagaattgg ctgtttctca aatgaatcaa atatatgaca
    11461 atcctaattc ttttgggcgt acttatggtg aacatcgtgc ttttcttgag cttgatgatc
    11521 aagcgcattt tgagatttat aaatatgcta agtcattagg attagatttt atcgagacgt
    11581 tatgtgccaa aggatgtctg tctttgctta aactgttcac accggatagg ctaaaagttg
    11641 ctagtcgtga tttgactaac ttaccattgc ttgaagcatt agcagaaact catattccta
    11701 ttatattatc gacaggaatg gctggtcaaa gagaacttga caatgcatta gatgtgataa
    11761 cgagatatca tagtaatata gctattctac attgtgtatc tcagtatcca actcatccaa
    11821 ataatttgaa tctacgtaca ataacatatt tgaagaagca ttacaataag tttgagatag
    11881 gtttttctga tcatacaata ggtatttctg ctgctacagc tgctgtagcg atgggagcgg
    11941 aaattataga aaagcatgta acaattgatc ggcatatgaa aggaacagac cagcttggct
    12001 ctttaggtcc agatggggtt aatcgtatga ttcgagatat tcgcatagca gagtgttggc
    12061 ttggtactga agatctttat atagaaaaag gggtggagaa gtctaagata aaacttgaac
    12121 gttctattgc cactcgaaaa tatattccag caggtagtat tattcaagag tcggacattc
    12181 atttactgag tcctggtgat ggttataaat ggatagataa aaaaaatgta attggtcatt
    12241 ttgctaaaca agatatatca gcgaatgaaa taatatatcc tgattttatt gaatagatat
    12301 attcctactg caacttgtat tacggtatag agtactgcct gctataagct aagtagtgat
    12361 taataaataa gggtaaaata ctaaaaaaat gaaagagata aagcttatac ttacagatat
    12421 tgatggcgtt tggactgatg gcggaatgtt ttatgatc
//
