LOCUS       c00033_gnlPro..        16690 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PDLMHNFB_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:13:34
            Original ID  :: gnl|Prokka|PDLMHNFB_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16690
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16690
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3200:6758](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3201..6758
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16690
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16690
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(628..1782)
                     /locus_tag="ctg33_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDWKFSPWGWDPALRKRLMTLGAGQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1962..3167
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3201..6758
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_3"
                     /sec_met_domain="PFOR_II (E-value: 5e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6883..7071
                     /locus_tag="ctg33_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(7082..7942)
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVIPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7970..8800)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8797..10023)
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10496..11782
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPIPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11745..12077)
                     /locus_tag="ctg33_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12105..14858)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTVCSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15191..16417)
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGHRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 aacataggaa taagaataac aaaagtaaac ctatttagat attaaagtat attgagtaaa
       61 ctaattcagt tataacaaac gaagttgtca actaaaacca gtacacatca ccaattccaa
      121 tttagcagta tcttcaaaga gtttccattg cttgaaacca gagtttcatc ggtgtgaaac
      181 tgtagtttca tcggtgagaa actagagttt catacgcttg aaactttagt tccaaacgct
      241 cgaaactatc tgaaactact gttgatttga ttgacttaac cgcatgttcc aatcacattg
      301 aacgcatcag ctacttcaat agtactgctc tctctgaaaa cattaaatca tatatcagtc
      361 aataatacat aaattatcag tccttaatac ttgatttctc aattattaat atctgagaaa
      421 tcaaacgtta acagttgaga tatcagatat taacatcctg taaatcaaag aataacacag
      481 taaaaacagt atttatcagg acgatgcaga gtgagagcaa gtccttgctc tcactctgct
      541 accactggat ctctaacagc taaaacatcg atgaataaag ggatacagac gaactgttag
      601 agcatgagag caaaagcact atctttttca ctgggggaga gtaagcaaaa gaaacgcacg
      661 ataccggctt tgaggcgtca ccggtactaa cggcaaatat ccggcacaca cccgattatt
      721 ctctacggac aaagggaacg aagccgacat ctgccgatgt tcctccaaag cctgaccggc
      781 taaaggataa taatcaatcc gaaaaactcc ttccgcatcc gcagccaaat aacgatccgt
      841 caagagccat gccaccaccc ccatattcat tcgcagatta atttcgacac aaggatgaat
      901 ccggtaaaca ggcgcttcat ccggaaaatg acaaatcatc atatccactc ccaagtatcc
      961 atgataaaag ccaccgaaca aagctgacaa ttcttcttcc aaacgagtcc gcagcctgat
     1021 aaattcttct tgtggcacat aagccgatag tttctgcaga atcttctcgt cagacagcaa
     1081 gtcattccct gcatacatcc cactcccacc cgtgtggaag accgaatatc cggcaaaaac
     1141 aacccttcct ctcccgtcag cataaaactc catagcgaaa tcttccacct tattatatat
     1201 aggttcgcct accaccccac cctgagaagc agcgacacgg gcacaccaac cggaaataaa
     1261 agtagtaaat atgcctttac accaattcaa tcctttcccg cttccggaaa gcggagcttt
     1321 taacaagcac gcttcccgcc cttcgacgaa cgcactgcac tccgccaaag tactcaaata
     1381 aaaagattct ccacagaagt attcattcaa ccgcaaccca ggcaacaact ttaccgcctg
     1441 cagacgatgc gaatgctctc tcagaatatt catataatcc gcagaaggca gctccgtctg
     1501 acctgccccc aatgtcatca aacgcttccg caaagcaggg tcccaacccc acggagagaa
     1561 cttccagtct ttaccgtcag ccacttccgg ttccgtcaac aaggccacat ccatgcccaa
     1621 aagttcactc tttgttttca ggaagtccgc attataagca gacggtgcaa gcaccgcact
     1681 tcccgcttcg gcataccaca taggaagcaa cgccaggtca ctcgccatct gtcgggcgga
     1741 agccggcgcc atatagttcg tctcaccgct tgccaacgcc atatcatgct ccggattgaa
     1801 tatataaaca ggtcttttcg tcatgtcaaa gatggattca acacattatt ctgcaaatat
     1861 atacaggaaa taatcaggaa cttacacaat aaagagaaac ttataaatta aagcacattt
     1921 ttgctatctc tactttgcaa atcctaaaaa aagcactata tttgccagcc gaaaaacaaa
     1981 gaaacgaaat ggaatcattc tatcgcacac acgcctacct cgttgagcac accaatgccc
     2041 ccgttcgccg cgatcttatg gacgagatcg actggagtga ccgtctgatt ggtatcaaag
     2101 ggacacgtgg cgtaggaaaa accactttcc tcctgcagta cgccaaagag aaattcggca
     2161 ccgaccgttc ctgtctgttc atcaatatga acaactttta tttctccggt cacagccttg
     2221 ttgacttcgc caacgagttt cagaaacgtg gcggaaaagt actgctgatc gaccaggtgt
     2281 tcaaacatcc cgaatggagc aaagagctac gaatgtgcta tgaccgtttc cccagcctga
     2341 agattgtctt caccggttct tccgtcatgc gactcaaaga ggaaaacctc gaattgcgtg
     2401 acattgcgaa aagttataac ctgcgcggat tctctttccg tgaatttctg aacctgcaga
     2461 caggaatgaa attccgggca tacagcctcg aagaaatcct cagtacacat gaacagatag
     2521 ccaaaggagt actttccaaa gtacgaccgc tggattattt tcaggattac ctgcatcatg
     2581 gtttctaccc tttcttcctt gaaaaacgta atttctcgga gaatctgctg aaaacaatga
     2641 acatgatggt agaagtggat atcttgctga tcaaacaaat tgagctgaaa tatctttcaa
     2701 agataaaaaa attactatat ttgttggctg tggacggacc gaaagctccg aacgtgagcc
     2761 aactggcaag tgacgtacag acatcccgcg ctacggtaat gaactatatc aagtatctgg
     2821 cagacgcgcg tctgattaat ctggtttacc cgaaaggaga agaattccca aagaaaccgt
     2881 caaagattat gatgcacaac tctaacctga tgtactccat ttatccggtg aaagtggaag
     2941 aacaggatgt actcgacacg ttcttcgtta acactttatg gaaagaccat aaggtacata
     3001 aaggagataa aaacgtctct ttcatggtag acgaagtgat gccgttcaaa atttgtgcgg
     3061 aaggtacaaa aataaagaat aacccggacg tgacgtatgc gttgcaaaag gccgagatag
     3121 gccgcggcaa ccaaatacct ctttggatgt tcggattctt atactaaaaa gatttattta
     3181 cttaaatatt taatttagtt atgactaaac agaagaaatt catcacatgt gatggtaacc
     3241 aagctgcagc acatatctcg tatatgttct ctgaagtagc agctatctac cccatcactc
     3301 cttcttcgac tatggctgag tacgtagacg aatgggctgc cgcaggacgt aagaacatct
     3361 tcggcgaaac agtattggta caggaaatgc aatctgaagg tggtgctgcc ggtgcagttc
     3421 acggttctct tcaggctggt gcattgacta ctacttacac tgcttctcag ggtcttcttt
     3481 tgatgatccc taacatgtac aagattgccg gtgaattctt gccttgtgta ttccacgttt
     3541 ctgctcgtac actggcttct cacgcattgt gtatcttcgg tgaccatcag gacgtaatgt
     3601 cagctcgtca aaccggcttc gctatgttgg cagaaggttc tgtacaggaa gttatggatt
     3661 tggcaggtgt tgctcatctg gctactatca aatcacgcgt tccgttcatg aacttcttcg
     3721 atggtttccg tacttctcac gaaatccaga agatcgaaat gttggaaaac gacgacctcg
     3781 ctccgctgat cgaccaggaa gctttggctg aattccgtgc ccgtgcactg aatccgatga
     3841 agccggttgc ccgtggtatg gctgaaaacc ccgaccactt cttccaacat cgtgaatcat
     3901 gcaataacta ctatgaagca gttcctgcta tcgtagaaga atacatgaac gaaatttcca
     3961 agatcacagg ccgcaaatac ggtttgttcg attactacgg tgcagaagat gcagaacgcg
     4021 taattatcgc aatgggttct gtaactgaag ctgcccgcga agctatcgac cacttggtag
     4081 caaacggcga aaaagtaggt atggttgccg tacacttgta tcgtccgttc tctgctaaac
     4141 acttcctggc tgctgtaccc aagactgcaa agagcatcgc agtgcttgac cgtacaaaag
     4201 aaccgggtgc taacggcgaa cctctttacc ttgacgttaa agactgcttc tatggcgcag
     4261 aaaatgctcc tgttatcgtt ggcggtcgct acggtctggg ttcaaaagat accactccgg
     4321 cacagatcat ctctgtattc gaaaacttgg ctatgccaat gccgaagaac cacttcacta
     4381 tcggtatcgt agacgacgtt acgttcactt ctcttcctca gaaagaagaa atcgctctgg
     4441 gcggtgaagg tatgttcgaa gctaaattct acggtctggg tgctgacggc acagtaggtg
     4501 ccaacaagaa ctctgttaag attatcggtg acaacaccga caaacactgt caggcttact
     4561 tctcttacga ctccaagaag tcgggtggtt tcacttgttc tcacttgcgt ttcggtgata
     4621 ctccgatccg ttctacttac ttggtaaata ctccgaactt cgttgcttgt cacgttcagg
     4681 cttacctgca catgtacgac gtaacacgtg gtttgcgtaa gaacggttct ttcttgctga
     4741 ataccatctg ggaaggcgaa gaactggcta agaacctgcc taacaaggtg aagaaatact
     4801 ttgcacagaa caacatctct gtatactata tcaacgcaac tcagattgca atggaaattg
     4861 gtttgggcaa ccgtaccaat acaatccttc agtctgcatt cttccgtatc acaggcgtaa
     4921 tccctgtaga tcaagctgtt gaacagatga agaaattcat cgttaagtct tacggcaaga
     4981 agggtgaaga cgttgttaac aagaactacg ctgctgtaga ccgcggtggt gaatacaaga
     5041 ctctgactgt cgatcctgct tgggctaacc tgccggatga tgcaaaagca gaaaacaatg
     5101 atcctgcttt catcaacgaa gtagttcgtc cgatcaatgc acaggacggt gacttgctgc
     5161 cggtatctgc attcaagggt atcgaagacg gtacttggta tcaaggtact tccaaatacg
     5221 aaaaacgtgg tgtagctgca ttcgttcccg aatggaatgc tgaaaactgt attcagtgta
     5281 acaagtgtgc ttacgtttgt cctcacgctt ctatccgtcc gttcgtactc gatgctgaag
     5341 agcagaaggg tgctaagttc gagcaactga aagctgtagg taaagcattc gatggtatga
     5401 cattccgtat tcaggtagac gttctcgact gtctgggttg cggtaactgt gccgacatct
     5461 gtccgggtaa tccgaagaag ggtggcaagg cattgaccat gaaacacctt gaaagccagt
     5521 tggccgaagc tgataactgg acttactgcg ctgaaaacgt gaagagcaaa caacacctgg
     5581 tagacatcaa ggctaacgtg aagaactctc agttcgcaac tccgttgttt gagttctcag
     5641 gcgcttgctc cggttgtggt gaaactccgt acgtgaaact gatttctcag ttgttcggtg
     5701 accgtgaaat ggttgctaac gctacaggat gttcttctat ctactccggt tcagttcctt
     5761 ctactccgta cactatgaac gaaaagggtc acggtcctgc atgggctaac tccttgttcg
     5821 aagacttctg tgaatttggt ctgggtatgg aactggctaa cgaaaagatg cgtgcccgtc
     5881 tggtgaaagt aatgaacgaa gctatcgctt ctgattgctg cccggctgaa tacaaagaag
     5941 tatttgctga atggatcaac aatatgctgg atgcagaaaa gactaaggaa ctggccgaaa
     6001 agatcattcc gatggtagaa gctgctaaag ataaatgcaa ccactgcaag caaatcgctg
     6061 atctgcaaca atatcttgtt aaacgcagcc aatggatcat cggtggtgac ggtgcttctt
     6121 atgatatcgg ttacggtggt cttgaccatg taatcgcttc cggtaaggac gttaacatcc
     6181 ttgtattgga tactgaggtt tactctaaca caggtggtca gtcttctaaa gctactccgg
     6241 taggcgctat cgctaagttt gctgctgcag gtaagcgtgt acgtaagaaa gacctcggtc
     6301 tgatggctac tacttacggt tatgtatatg ttgctcagat tgctatgggt gctgaccagg
     6361 ctcagactct gaaagctatc cgtgaagctg aagcatatcc gggaccatca ctgatcatcg
     6421 cttacgctcc atgtatcaac cacggtctga aagccggtat gggtaagagc caggaagaag
     6481 aagaaaaggc tgttaagtgc ggttactggc acttgtggcg ttacaaccct gctttggaag
     6541 aagaaggcaa gaatccgttc caactggata gcaaagaacc taactgggaa gacttccaag
     6601 gtttcttgaa gggtgaagtt cgttacgctt ctgtaatgaa acaatatcct gctgaagctg
     6661 aagaactgtt taaagctgct gaagaaaacg ctaaatggcg ttacaacagc tacaaacgtc
     6721 ttgccagaga aaactgggga gctgatacag ctgaataata agtagaaata ctttatacat
     6781 aataaaaggc aggaatcctg gaaacagatt cctgcctttt ttgtttatat cttagaagta
     6841 acgattactt ctcacgaaga tattcattaa aactctaaag atatgatcgg atttgttatt
     6901 tggattatcg gtttgatact gactttcaga gctgccatag agatttggaa tataaatgcg
     6961 gctgtagaga aaagacttat agcgattgta ttaatcgttc ttaccagctg gctgggacta
     7021 cttttctact acttctatgg taaagaaaga atggcaggat ggttgaagta gtgtttgcat
     7081 atcaatcttt ctcaggaatc caactgttta ccagttcctg atgttcttcc atccattgac
     7141 gggcagcctg tctttccgtt gtctgcgcct cttccagagc agtcattaaa gagctgattt
     7201 ccgcatctgt cagacgaatg ttgcccaaaa gttcggcagc aaaagggtct ttctcgctaa
     7261 aacctttcca tgctatggta tgaatggatt ccgtatttcc atatatcagc ttcgggtcct
     7321 gaagaacttt cagcttgaaa cggtcgaaca tccagtgagg cgtccatccc gtcacgacaa
     7381 tccagtcttt cttatcaatc gctttcttta gggaagcagt catggcaggt ccgctcgaag
     7441 tcatcagttt ataatccaat ccatagtctt tgatggcctg atcggtagct ttcataatac
     7501 cggctccggc atcaataccg acaatctgac cggagaaacg ttccttttcc gcgttcagtt
     7561 cttcgattga gttgatcgta acgtaatccg gaatcaccag cccgatacgg gcaccatcat
     7621 aaatatcccc gataacttcg agtttatccc cgtattgttt catataatct tccatagtga
     7681 caggcatcca gacatccata aatacgtctg ctttcttacg ggagatagag gtaaatatag
     7741 gtgcaaggtc ggcattcagc aactttacat cgtacccctg atcttcaaaa atcgctttgg
     7801 caaggtttgt cattgcaata ccttccgacc agttggcata agcgatactt atcttcttac
     7861 tctttccgtt gtctccgcag gaaacgaagg ttaagagtat gccggcaata aacattgccg
     7921 caatcatttt tatcttattc attgattatt cctttctttg gtgtgattct tatttctttt
     7981 tactttttct gttatctgcc ataccctgag tgatgcggtc cagcacgatc gccaatatca
     8041 cgactgcgat accgccttca aatccgagtc cgattttcat ttgggtgata cctttcagca
     8101 cgatttctcc caaccctccc gcagaaatca tggcggcaat cactaccatc gaaagtgaca
     8161 tcatgatcgt ctgattgatt cccgtcagaa tagtaggcaa tgccaaaggc aattgcacct
     8221 tataaagaag ctgccaggga gtagctccaa aagaacggga ggcttctact acatttttag
     8281 gaacctgacg aatgcccaga ccagtcagac gaaccacagg aggcattgca aagatgatgg
     8341 tggcaaaagc tcccggcaca gttcccaatc cgaagaatag aacggcagga atcagataga
     8401 caaaggcagg cattgtctgc ataaagtcga ggacagggcg cattatcttg ttacaacgat
     8461 cactgttggc agtccagatt cccaacggaa cgcctaaaag caatgccaga caagtggaag
     8521 aaagtaccaa tgccaatgtc tgcatcgttt cttcccaaaa gcccatgccg taaataagca
     8581 ataaacccaa gagggtaaat acggctgtcc ccttacccga cttaaaccag gcgagcgcag
     8641 ccagcactgc aattgtgata taaaaaggta ttccaaacag tacgtgctga aaaccgtcta
     8701 tgaatcctcc gatccccatg ctgagagcat caaaaaagga agcaaaatgt tctgtgagcc
     8761 aattaatggc agtctctata tattgtccga tatttatcat aattctattg cgttttgaat
     8821 gatttcatta atttcttctt tatcttttcc cgttacttcg atgatcaatg aggaaagtgg
     8881 cactacgcct tcaaactccc gattctcatt tacgacccag attggcgagt tcgtttttgt
     8941 catcaacgga agaatatctt ccagcaccgt atcacccagc actgaatgaa cttcatgcct
     9001 tactacggac tcgatggagc ggatttgctc ttttcgtagt ttcagcaagt cattcaaccg
     9061 cacctctcct actaacagat tattggaatc gactaccgga agaacggtca gattccgttc
     9121 gcgcatctta cggatcagca cctccgggcc ttctttcttc aaacgtgcca ctatgggttt
     9181 atctaccata acagaggaag ctgttataat cttgcttcga tctacattct ccacaaatcg
     9241 ttctacataa gcgttggcag gttcggtcag gatttcttcc gatgtaccga tttgtacaat
     9301 ttctccatcc ttcatgatag caatccggtc acccaattta atcgcttcac tcaggtcgtg
     9361 agtaataaag acaatcgttt ttttcatctt cgactgcaaa gtcagcagtt catcctgcat
     9421 ctgcacacgg atcaaaggat cgagtgccga gaaggcctca tccatcaaca ggacttcggg
     9481 attattggcc aaagcccgcg ccagcccgac acgctgctgc atcccacccg acagttcact
     9541 taccatctga ttctcgtagc ctttcagccc caccagttgc atactttcca tcgctttctg
     9601 ctcccgttct ccctttttta ctccctgtag ttcgagcccg aaagctatat tatgcaagac
     9661 agaacggtga ggaagcagac cgaagttctg aaagaccata gccagttctt tccggcgaat
     9721 ctgcaacagt tccttatccg acactttggc tatgtctgtt ccattgataa tcacttctcc
     9781 ggaagtaggg cgtatcaaac ggttgatgca gcggagtaaa gtggactttc cactaccgga
     9841 cagccccata atgacgaata tttcgccttc attaatggaa agattcgcat ctttcaccgc
     9901 aactgtacat ccggtcgctt tcaatatttc actttttgtt ttaccttctt tcaacatctt
     9961 caaagccttc tgcttctcat tgccaaaaac cagatagaga tctttaattt ctattttact
    10021 catacaataa aatggtttag gttattaaaa taatatacac agcaagacaa gaacaaacga
    10081 taacaggaat ctttctttat atcgtataaa gttctgattt aaataaggga caaataacaa
    10141 tgaatcccga aataattaat aaaatgatta ttgacagact gagtaattaa aaaaggaata
    10201 gaatttgata agataatcct ttcaacgaat agcaaaaaat agcattttta tgtataaaaa
    10261 cagcctgttc cagtatcttg ctggcacaaa gatacaaaaa acggattaaa catacaaatt
    10321 atattcaaaa tccggggcat acagagggct ttatttgtaa tgatatggaa agtttccggg
    10381 taatattccc ctatcactca gcaaaataga acaaaccggc agataaatat aaaataagtt
    10441 tgaatatttc acttaaacac cgtatatttg gcgtcaataa ctaaactaga tttatatgtt
    10501 caacagggct attacaattt tcctggggaa ggataattgt cattacacaa caaaagaaaa
    10561 acaaacaggt actgccacac tagacgacaa aagccaagta cagttcctta gtaaaaagaa
    10621 ccccaaaatg ccgtttttct atagccggcg gaatctctac atgataggtt tcctgctcgc
    10681 ttttatagtg actctgctcg aatttatacg aggacggcat caaaacttta tggtcttctc
    10741 ggacgctact caattcttct ggcaaggcat cagcccatac acaactgaat ttgtagaagc
    10801 tcacggacgc tacttccttt attctccagt tttcacggta ttgttcgctc cgtttgcgta
    10861 tctgcctgca tggctgggac ctttcgcgtg gaatctattc aattattcgc tgttctttat
    10921 ggcgatcttc acgctgcccc aacaattcac ccagcagcag aaatgccgta tgttcctttt
    10981 tctgttactg attttaggac aaagtttact ttcatttcag tataacataa cggtagccta
    11041 tttattctta ttcgcctata cgttattgga aaaagaccgt ggatttctgg ctgttctgtt
    11101 aatcatgatt tcgggatgta ccaaagtata tggaattttc gaactggcat tgttgctgtg
    11161 ctatcctcac gtatggcgta actttggcta tgccgttaca atgggcattg tattgcttgc
    11221 attaccgtta atcaaaatag ctcctgcaga tttgctcccc tattatgaag aatggtgcca
    11281 tagtcttgct gttcatcagt ccgccggagc ttatgattca tttttctatg cccgccccat
    11341 tgcagcatgg acattgccac acttccgtgc acttcagata ggaatgctcg gcttgctgac
    11401 tctgctcttt ttggggaatt tccgcaaatg gtcgtctttt gccttccgtg cccaggcttt
    11461 gggcattctc atgggctggg tagtattact gagtgactcc gccgagaagc atacctatat
    11521 tatcgcattg gcaggtttca tgctctggta ttggagcaga ccaacacgta ccgcaacaga
    11581 caagattcta ttttggtgct gttttgtgct gttatgtatc gttcctatcg acatattcgt
    11641 ccctataccc atcagagatt tcattaccag gaccttatgg cttcatgtat gggttttctt
    11701 tattgtatgg atacggatga tatggcttac cttccttgca tccttcattc atccacgtgc
    11761 cacaaatgtt ctttcagatt aacgcatccg ttagctttga aagaaacttc ttctgccagc
    11821 aagagttgtt tttgttccac ccaaccgggc accagccttc cggtggaatt tacaactcta
    11881 tggcagggaa tggataattc atccggcact tctttcaatg cacgtcccac catccgcgag
    11941 cattggggtg cccccaacag caaagcaata cctccataag tagatacttt tcccacaggt
    12001 atctgggata cgacttcgta cacttccttc cgaaaggatt cggaaaagct ctctttatct
    12061 actttataat ctttcatata tccctcttta cgatatcaat gaaatcatcc tttccttttc
    12121 aggaaatctg tcgggctctc tccaaactgc tctttatagc acttggcgaa ataagaaggt
    12181 gaactgaaac cgacttcata accaatctcc gctacggtca tgtccgaaga agcaagcaaa
    12241 gaagctgcct tcttcaaacg ggcgatacgg agcaattcat tcggagagta gttagtcaat
    12301 gatttaatct tgcgataaag ctgcacacgg cttagtccca tgtctttgcc caagtcctcc
    12361 acattcaaac cggagtctcc cattttctct tcaatcaatg acttgaatct ttctacaaaa
    12421 tccttgtcca tatcgcagac atcttctttt gccaatgtct gcccgtcacc aaagaactgt
    12481 ttcagacgac ggtgagaatc gatcagattg cggacacgtg ccagcaacag ctgtgaactg
    12541 aacggctttg aaatataaga atccgcacca ccgtcatatc cctgaatacg ctgttcgtcc
    12601 agtgaacaca ctgtcagcag aataaccgga atatgacagg tctgtaactc acttttcagc
    12661 cggcggcaac attcaatgcc atcaatgccc ggcatcatca catcagaaat gatcaggtcc
    12721 ggaacatact tcatagcctt acggattcct tcggagccgt ctgccgcttc aatcaccgta
    12781 tagtctgtat gcaacaacgt atggacatac gaacggatat cctcattatc atcaataatc
    12841 agtacggacg gtttggaaga gtcatatcct ttttccagtt cttcctcttc cgccaataga
    12901 acatctgttg tacgggaatc cgcagaaaca agggtggtat ccggttcggc agcaacagcc
    12961 tcacaagact gtacaggcag ttcaacggta aagaccgtgc cctgtttctc atcgctctct
    13021 acggagatca taccaccgtg catttctacg aaggctttta ccaatgccag tccgattccc
    13081 gaaccggtat ggtgcatatc gatcttatag aaacggtcga atacattgcg aatatgttcg
    13141 gcagaaatca tagaaccggt atttgccacc gtgaaacgta tccatcgctt gtcctcttta
    13201 ctaagggaag acagacggac ggctattttc ccgttttccg gtgtaaactt aaaggcattg
    13261 gacagaagat tgaaataaat acgttccagc ttctccatgt ctgccagtgt atgataatcc
    13321 gtatccggca tactatcaaa agaaaaatgg atatgcttct tacgggctgc cgcctgaaaa
    13381 gactcattcc atccttcgaa agaagaaagg acatccaccg taaccggagt atattccatc
    13441 ttgccgtttt catatttacg gaaatccaga atctgattga ccagacgcag aagaatgttc
    13501 acattccgct gaatcagcat gagcatccgg tgctgatctc cgctcagtgt cttgtccgcc
    13561 aacaaatgtt ctaccgggtc ggcaaccaat gtcaacggag tacggaagtc gtgagaaata
    13621 ttggtgaaaa agaccagctt ggcatgggta gcttcttcca gttgatgaga gagctgtatc
    13681 aattggtcac gctgttcttc cagtttgtca cgctgctctt ccaattgctg cttctgctta
    13741 aaaagctctt tattcaagcg attcttagag cggagtgatt tataaacgac caataataag
    13801 ccggctacca ataaaaggat aatcagactg ccgtataaaa cgacctgttg tgtagctacc
    13861 tgagagagat agccaccgat acgtccgttg agcgtttcaa tctttttgtc gagttcggaa
    13921 atgtgtgtgg tctgcaactg catgacgtgt gcgttggtac ggtccacaac agcggtattc
    13981 atcaccgttt ctttgggata gggtttcttc tccagaatgt ccatagccag ttgcagtacc
    14041 ttatcgccat tggtcggata gataaaggtg gcatccagca cactgtccag taccagttcc
    14101 agtccgtttc ccttacccgg caaggcatct atgccgacaa aaatcatttc cttctcccgc
    14161 cctgccatct ttgctgcctg ataggcaccc ggagcgatac ggtcattatg ggcatacaca
    14221 gcatcaatct taggatgcct ccgaagcata ctatccattt ctatctctgc cggaccacgt
    14281 tcccacgcag catccgcttt atcaatcagc tttatatccg ggaatttact gatggcagcc
    14341 ataaatccct gatgccgttc cattgcagga gtcgaaccgc tcaatcctgt cagttctact
    14401 atatttccct tccctttcag actggaggca atatagtttc ctaccgaacg accgatttca
    14461 taattatcgg ctccgatata ggcagtatat ttatccgaaa gaatcttccg gtctacaaga
    14521 ataacgggga tgcctttctg ataagcttct tctacaatcg gagtcatagg agcagcttcg
    14581 ttagcggaaa taatcagcag atcgactcct tcgtccataa aataatggac atcttccgcc
    14641 tgcttactgt tatcatcccc tgccgaacgg atttccaccg aaacaccatt ataaaacatc
    14701 gcttcccgaa gaatctcatc attcatctta tgtcgccatg aatcatcgct gcattgagcc
    14761 accccaatac gaaaacgggg tgtatcctgc cggcaagccg tcatcccgat taaaccaaac
    14821 agcaccagca tccacttcag atatctcatc gtcttcatcc atctcatcat ttcatagttc
    14881 tttctgtaat ccaattaaga acaaaaataa gaaataatac tgtaaagttc tctaacttca
    14941 gctatttatt attctaaaaa gaaggaaagc agtcctcttt cagaccatcg gaaagtatta
    15001 acaaaagtat aaagcgtaaa acaaacactt aatcaatgtt ataaaacata gcgttttact
    15061 tggataattt gcagatttca cagaagtccg tatctttgca ctgtgttttt catagtatta
    15121 gatttaaggt taacaaaggt tggagcaagg cgttgctcct ttttttatgc tctgaccttt
    15181 catctaccgg ttagttttca tcccattcct tttccagttt accatcaata gtgtagcgtt
    15241 tccatcgtcc tacacggtga ccattcttat attccccaca ttcacgaagc tggtcattct
    15301 ttacataacg agcttcgaac ggtccgttct gccttccgtt cacataggta gaagtttccc
    15361 aataatcaaa gcggttgctc actatcagcc gtcgttcctt gccatgcaat ctgccggcct
    15421 gataggtagc ttcatatctc aattcaccat tttccaaatt atattcacgg tataaaccgt
    15481 ctttacgatc gttcttcata taatattctt tctgccttac cccacttccg ttggcaaatg
    15541 agacatggag tccatcttct tttccatcca gataggtttc aatcatcagc gtatctccgc
    15601 tttcagcaaa agtagtccaa cgaccattct tctttccatt cttataacta cccagtatac
    15661 gtggcgagcc aaacgtaaac acggacgaat attcaccgtc ctgaaaacct tcttcattga
    15721 aataaacggt ctcatacaaa tcatatgtac ctttcagaaa agtatactgt ttgcctacct
    15781 gcttcccgtc cttgtaatta tgctctttcc gcaaagtacc gtcagattcg tacgacagtt
    15841 gcttcccgtg ctctttcccc atccggaagt ttctttcact ttccactttt ccggtagtaa
    15901 agtaactttt gctcgtaccg tccagcttac cttccttata ggacttttct tctttcagct
    15961 taccgtcaaa cttggagtta atcttgaaga ggccatcctt ccgcccttct ttataacttc
    16021 cttccgttat taatatattg tccacatatt ctttgtatcc gccatcataa aaaccatctt
    16081 taaaagatgc cagcacatag gcggaatgat aaccatctat gatgcgatgt tcgccattca
    16141 atgctttttc cgttttcagt tcctgaaaca acagtctgcc atcgcctaca ttaacaacag
    16201 atacctgatc gatcttatat tccttttgcg caaacaaagg aagagcaaga tataaaaaca
    16261 aaaatacgtt ccagcttttt gatctgagga agttcgaaat gtgtttcata aagtagtttt
    16321 ctctttttga tttattattt aaaaacctgc cgcaaagata ggcaatcggc ttataaaaca
    16381 aggcaagaaa gagggggaca attagaaaaa agaacatctg ttattatcat tctaataatt
    16441 aacagattaa gtagtaaatc aaaacacagg gaagggggac atttactgaa ataagaaaca
    16501 gaaaagaaga tgtgtcaaaa gcaactaaat tcccctcctt caggaaggag gagagtttag
    16561 ttgcttttga cacatttaca tttgcagtat taaatatcac aacaaaatat aagtgtatat
    16621 ttgaaaagta gagttgcagt gaactaactt tgacactagt cttaaatgac tataggctga
    16681 atcagactgc
//
