LOCUS       c00192_gnlPro..        13341 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AFKDHDOF_192.
ACCESSION   c00192_gnlPro..
VERSION     c00192_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:54:30
            Original ID  :: gnl|Prokka|AFKDHDOF_192
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6066
            Orig. end    :: 19407
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13341
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[16066:19407]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13341
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13341
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13341
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(453..1796)
                     /locus_tag="ctg192_8"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFRELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             complement(1822..2997)
                     /locus_tag="ctg192_9"
                     /transl_table=11
                     /translation="MQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQAVVNAAVQKAYGG
                     KRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLNVALRQ
                     TLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEKFYQFL
                     KNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTE
                     GGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVS
                     DQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVMMLEYL
                     GWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK"
     CDS             complement(3027..5270)
                     /locus_tag="ctg192_10"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DLKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDDFMKIGAVIMANACGPCIGQWKRHTDDPTRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPVGDELPLRGFTSGNEG
                     YITPGGTKTAINVNPASQRLQLLTPFPAWDGQDILNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNNVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQEHD
                     LLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             5337..7280
                     /locus_tag="ctg192_11"
                     /transl_table=11
                     /translation="MKYIFVSEGRFTTFASIMNNHPKSPIIDLQQQQLLLRVEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHSAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLITYIKQSSLS"
     CDS             complement(7338..9200)
                     /locus_tag="ctg192_12"
                     /transl_table=11
                     /translation="MRSYSCILKVIVVYALLGIVIASCIDKDTDYSRPDDPQTPNDFDY
                     STTQQVQLNVQYEVPEGYQVLFDVYFENPFEIDEEGQVVKRTDVVPKVTRMTDGNGKYA
                     GLEVIPGYLDGDIYIYSSYIGVPTLYKTTLQGNKIQADISWDTMYDFVSAAPTRVESNF
                     TYPKAFNILGDWDENGRPDYLDSEGALSLSQPIMNAINRTLPEDGKCPQKYRQSVDFEI
                     KEPAHVKVRFIGGKSSAYSTFGYYCYKADASIGEIKKAKKYIVFPNTRTGIGLKGGECV
                     ALHYIDENGVDRGTDFPKGIKIGWFIRNAAFWKGNIGEGKGMFYSTPKLNTDGRTHTVA
                     FRINDFVVLSFEDWTDQDYNDVMFNVWSDPIEAIVTPDLPEVIPPGDPDDSSIAYSMTY
                     KGILAFEDNWPSKGDYDLNDVVVKYNSVLSFNTKNEVLSTKDTFTVLWSGASYSNSFIY
                     QLNTDKSNVESSLEVDKDLALATIPVFVDVKTETGDNTKTSTVNVTNKFKTPVDHEVLG
                     GAPYNPFISVFKYTGYDRTEVHLVNHKPTEKAKKALFHTGEDLSDLNAGIYYVSASKYP
                     FAINLSDAEVYSTEEREAVDKTYPRFVSWAESNGAKDKDWYLGK"
     CDS             complement(10001..11044)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg192_13"
                     /sec_met_domain="IlvN (E-value: 5.2e-47, bitscore: 149.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.8e-40, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(11108..11851)
                     /locus_tag="ctg192_14"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGNELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             complement(11851..12414)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg192_15"
                     /sec_met_domain="ALS_ss_C (E-value: 8.8e-20, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             complement(12433..13341)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg192_16"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-47, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="NLGPNINTNKCDVLIAVGMRFDDRVTGNLATYAKQAKVIHFDIDP
                     AEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVEEEKVIRPELHPA
                     TDSLSMGEVVRAVSEATRHEAILVTDVGQNQMISARYFKYTRERSIVTSGGLGTMGFGL
                     PAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLNNNYLGNVRQWQA
                     MFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLSTDGAFLLEACVVE
                     EGNVLPMTPPGGSVNQMLLEC"
ORIGIN
        1 aatggccaca aaaaactgaa agaactattc gtattgaccg gacaggaaac ttatgaatat
       61 cacaattatc ttttttccat cccgtgttct ctttcatatg acaccatggg cttttagcac
      121 atagttcact gatatccaaa gaaatagaat gtataattca tcggttgtag aaacgccctt
      181 ttaacgtagc gttaaaaggg cgtttctacc tgccaggctg tgccctttct accaacgata
      241 aatgccttag cctccatcgg atgaaaaata cagcaaccgc aaagtgttaa atgttaaatg
      301 aacatcggat gttcttcctg aaacaagtca ccccagacgt acaaccgggt actaccaaga
      361 tgtacaactg gggattacca agacgtacat gcagggatta ccgagatgta cgtctgaggt
      421 tagttattat tgcataaaag gatttgttct tatcagcgtt tcttgatggg gatataagcc
      481 agatcatcaa gaacattttt ataagccgga cggataatgc gtttgccttc gaagttcagt
      541 tcctcattgc ggtgcgcaca ccagccgaca atacgagcca tggcaaacag cggagtgaaa
      601 atctcctgcg gcaaaccaat catctcatat acgaagcccg aatagaagtc gatattgctg
      661 gaaaccgtct ttccgttgtt cttcacacgt ccgaaagtag cgatggcacg ctcttcaagc
      721 agttcgagga aagcgaactc ctcttctttt cctttctcac gggcaaggtc acgagccagt
      781 tctttcagca acagcgcacg aggatcagaa attgtgtaaa cagcatgacc gataccgtaa
      841 atcaatccgg tcttattata cacttcctta ttcagcatcc gtgtgaaata ggtatctatc
      901 tcgtccacgc tcttccagtc cttgatgttc tcctgcaagt gatggaacat atcggccacc
      961 tggatattcg cgcctccgtg aagcgggcct ttcaacgaac cgatacctgc ggcgatggcc
     1021 gaatatgtat ctgttccggt ggaagaagtc acacgaaccg tgaaagtcga gttgttacca
     1081 ccgccgtgtt ctgcctgcaa aatcaatagc aagtcgagcg tacgagcatc cagttccgta
     1141 taatcttttt tgagcatata gaggaaattc tcggcaatag agagtttctc ctgcggatga
     1201 cggatgtgca gggaacggcc gaatgtagca tggcggagca tattataagc atacgcaatg
     1261 atggtcggaa acttggagat aagatcgata ctctggcgca tcagattatc gcgggaagta
     1321 tcgtcggcat cgggatcgaa acggtacatt tcgagtacgc tgcgcgaaag aatattcatg
     1381 atattatttc cctccagctc gataatattc attttcgtct tctgttcgag cgccatattg
     1441 tcattgatca gttcgcggaa agaagccagt tcttccttgt ccggcaggcg accggaaagc
     1501 agcagataag ccacttcttc gaagccgaaa cgtttttcct tgatgatggc gtgggaaatg
     1561 tcttccacat cgtagccccg atagaacaat tttcccggaa ttggcttcag accgccgccg
     1621 gggatacgtt cgtaacctac cacattacca atctttgtca gacctaccaa tacaccggtg
     1681 ccgtcttcat tacgcagtcc acgcttcacg tcaaacttgg ggaacaattc attgtcaatc
     1741 cgggttgcct ctttcatctc ctcggagagc ttgtaaatca aatactcttt cttcataata
     1801 cttcgttttt aatcgttaca tttacttttc gattctttcc acaatttcgc gtgtgaaagc
     1861 ggtggtagac agggatgtac ctcccggcat aaagcgagcc agatcgtgcg tggcacgggc
     1921 atcgaggaaa ctctgttcca acgccttttc gataagcgcg gccgcttctt tccatcccag
     1981 atattcaagc atcatcaccg ccgaaagaat gatagaacaa ggattcacga catcctttcc
     2041 ggcaatgttg ggggcggttc catgagtcgc ttcaaaaatg gcgtgccccg tcttgtagtt
     2101 aatatttgct cccggagcaa tgccgatgcc gcctaccatt gccgccaact ggtcggaaac
     2161 atagtctccg ttcaggttca gcgtggcaat cacggaatac tcttcgggaa tcagtaatgt
     2221 attttgcagg aaagcatcgg cgatgcagtc ctttatcacc agccggccgt ctgccagcgc
     2281 gtcgccaaac tcacgttgcg ccagctcata gccccatttc ttgaagcctc cttcggtgaa
     2341 cttcatgatg tttcctttgt gcaccagtgt cacggaaggc agatgatggt cgagcgcata
     2401 ctggcaggca gcccgcacaa gacgttccgt gccctcacgg gaaacaggtt tcactccaaa
     2461 agaagaggtc tcggggaagc ggactttcgt cactcccatc tcgtttttca ggaattgata
     2521 gaacttctcg gcttcgggag tacctgcctc ccactcgatt cctgcatata tatcctccgt
     2581 attttcacgg aacacgcaca tgttcacttt ttccggtgct ttcaccggag aatgaacgcc
     2641 ttgataccaa cgaaccggac gcagacaaac atataaatcc agagtttggc gcaaagccac
     2701 gttcaaagaa cggattccac cgccgacagg ggtcgtcagc ggacccttga tgccgatcaa
     2761 atattcttgg aaagccttca tcgtttcatc cggcaaccac gaacctgtct cgttgaaagc
     2821 gcgttcgccc gccagcactt ctttccattc aatccggcgt ttgccgccat atgctttctg
     2881 aacagccgcg ttcacaacgg cttgcatcga cggagttact tccgctccta ctccgtctcc
     2941 ggtaatataa ggtacgacag gcacatcggg caccgacagc gtaccatctt tttgcatggt
     3001 tattttgttc atttctatca ttttaattat ctggcattca aggcagagcc ggcacggaac
     3061 caagcaatct gctgttcgtt gtatgtatgt tgcgcttcaa aactctcttt cgttccgtct
     3121 tcatgatgga gaacgacggt cagattccgt cccggagcaa agtccggcaa accgatgact
     3181 gaaaggaggt cgtgctcctg tatcttgtca taatccgctt tgtccgcaaa ggtaagagca
     3241 agcatgccct gctttttcag attcgtttcg tggatacggg cgaagctctt ggcgagaatc
     3301 acacgcacat tcaggaaacg gggttccatt gccgcgtgct cgcgactgga gccttctcca
     3361 tagttttctt cggccacgac aatggagggg attccttcgg atttatacat tttggctgtg
     3421 cccgaaacgg ttccgtaagt gtttgttgaa cggttccaca cgttgttcgt ttcgccattg
     3481 aaggcattca cggctcccat cagcatatta tccgaaatat tctccaaatg tccgcggaaa
     3541 cgcagccacg gtcccgccat cgaaatatgg tcggtagtac atttgccctg cgccttaatc
     3601 agcagaggca tattgagtat atcttgtccg tcccaagcag ggaaaggagt cagcagttgc
     3661 aggcgttggg aagccgggtt gacgttgatc gctgttttcg tcccgccggg ggtgatatag
     3721 ccttcattgc cggaggtgaa acctctcaag gggagttcat ctcctacggg ttcggccagt
     3781 ttcactttct cgccgtcatg gttcatcagt ctgtctttca gcggattgaa gcaaagatca
     3841 ccggcaatgg tcagtgccat cgtcagttcg ggagaagcaa caaaggcgta tgtgttcgga
     3901 ttgccgtccg cacgtttggc aaagttacgg ttgaaggagg tgacgatcga gttcttccgc
     3961 gtcgggtcgt ccgtatgacg tttccactga ccgatgcaag ggccgcaggc atttgccatg
     4021 atcacggcgc cgatcttcat gaagtcatcc atcattccgt ctctttcggc agtagcgcgg
     4081 atttgttcgg aacccggatt gataatcagc ggggaagcca cactcagatt cttttccttc
     4141 acctgccttg caagggatgc ggcacggctg agatcttggt aagaagagtt ggtacacgaa
     4201 ccgatcagtc cgacttccat cttacgcgga tagccgttca gtaatacttt ttctgcaaat
     4261 tcagagatag gggtagcggc atccggtgtg aaagggccgt tgatataagg ttcgagcgta
     4321 gacaaatcga tgtcgatgac acggtcgtag tacttttccg gttcgtccgt cacctgttgg
     4381 tccgcacgga gctcacagtc cacggcttcc gccagttcca cgatacgatc tctgccggtg
     4441 gctctcagat aagtagccat gcgcccgtcg aacgggaaaa gcgaagtggt agctcctact
     4501 tccgcaccca tattgcaaat ggtcgctttg ccggtagccg acagggaagc tgttcccggt
     4561 ccgaaatatt cgatgatgga gttcgttcct ccttttacgg tcagaatccc tgcaagtttc
     4621 aggatgacat ctttcgggga agtccagccg ctcagttttc cggtcaggcg gacaccgata
     4681 atccttggca ttttcagttc ccattccata cccgtcatca cgtctacggc atccgcaccg
     4741 ccgacaccga tggccaccat gcccagtcct ccggcattcg gagtgtgaga gtcggttcct
     4801 accatcatcc cgccggggaa agcgtagttt tcgagcacta cctggtgaat gataccggca
     4861 cccggcttcc agaagccgat gccgtaacga gaggatacat cgcgcaaaaa gtcgtaaact
     4921 tcttcgtttg ttttggttgc cgtagcgatg tcctcctttg ctcctttgta cgcctgtatc
     4981 aagtggtcac agtgcacggt ggagggaaca gccacttttt cttttcctgc attcatgaat
     5041 tgaagcaatg ccatctgggc agtcgcgtcc tgcatagcga cgcggtcggg acggaaattt
     5101 acgtagtctt caccccgctt gtagtttttc agatcgccct cattgaacag atgggcatac
     5161 agaattttct cggctaacgt caatgggcgt ttcaaaacag cccgcacgtg ttccactttt
     5221 cctttataag cagaataaaa agcctctaac atagtcaaat catacaccat attgctttta
     5281 ttttttttag tctatctata aaaataacga acggcgttcg aggaatgttt aacaaaatga
     5341 aatatatttt cgtctcagaa ggaagattta ctacctttgc atctattatg aataatcatc
     5401 cgaaaagtcc aatcatcgac cttcagcaac agcaactcct gctacgcgtg gagtatgaac
     5461 acgaaaagga ggaattcaag cggcagactg aaacaatggg tgtcgcccgc aaagtgaaac
     5521 gtggtctgtg ctggtatccc gcctctcccg gtcgaagtta ctataattct ctaaatcaac
     5581 ttgtaataga tattacacgc accgaaaata aagaaatcga gcattccttc gaattcggtc
     5641 gtcccgtctg ctttttccgg cagtcatttg acggaaaagt gaattacatg aatttcattg
     5701 caacggtgag ttatgcggac gacgaacgga tggtggtcgt gcttcccagt gcgggcgcct
     5761 tactggaact gcaaacggaa gaggtgctgg gtgtacaact ttatttcgat gaaacgtcct
     5821 atcgtgccat gttcgaagcg ctggaagaca caatccgcgc taagggcaac cgccttgccg
     5881 aactccggga caccttgctg ggaacacaaa agccgggatt ccgcgaatta tatcccgtcc
     5941 gtttcccgtg gctgaacagc acgcaggaaa cagccgtaaa caaagtgtta tgcacacgcg
     6001 atgtcgccat cgttcacggc cctccgggaa ccggaaagac taccacgctc gtggaagcca
     6061 tttacgaaac gcttcaccgc gaaccgcagg tgctggtctg cgcccaaagt aatacggctg
     6121 tggactggat ttgcgagaaa ctggtagacc ggggtgtgcc tgtcctccgc attggtaacc
     6181 ctacacgtgt taatgacaaa atgctttctt tcacttacga acgccgcttt gagaatcatt
     6241 cggcctaccc cgaactttgg ggaatccgaa aatcgatccg tgaaatgggc agccggatgc
     6301 gtcggggaag ttactccgaa agggaaggaa tgcgcagccg gatgagccgc ctccgcgacc
     6361 gtgccaccga actggaaatc ctgatcaacg ccgatctttt cgacagtgcc cgtgtgattg
     6421 cttctacgct ggtcagcagc aatcaccgtt tgctcaacgg aaggcgtttc cccaccttat
     6481 ttatcgatga agccgcccag gcactcgaag ccgcctgttg gatcgccatc cgaaaggccg
     6541 accgtgtgat tcttgccggc gaccattgcc agctccctcc tacaatcaaa tgtatcgaag
     6601 ccgcccgtgg cggactggac catactttaa tggaaaaagt cgtgcagcaa aaaccttctg
     6661 ccgtctcgct gctcaaagtg caataccgga tgcacgaggc aatcatgcgc tttccctccg
     6721 aatggttcta caacggagaa ctggaagccg caccggaagt gcgcaaccgg ggtatccttg
     6781 acttcgacac tcccatgaac tggatagata cctcggaaat ggacttccac gaagagtttg
     6841 taggcgagag cttcgggcgc atcaacaagc aggaagccaa cttgttactg caagaactgg
     6901 aagcctatat cagccggatc ggcaaagcac gcatcctgga cgagagcatc gactttggtc
     6961 tgatttcgcc ctacaaggcg caagtgcaat acctgagaag taaaatcaga ggaagcagtt
     7021 ttctccgccc tttccgcagc ctcatcacgg tcaacacggt agacggcttt cagggacagg
     7081 aacgggatgt cgtctttatc agcctcgtcc gggcgaacga ggacggacag atcggttttc
     7141 tgaatgattt aagacgaatg aacgtagcca ttacccgcgc ccggatgaaa cttgtgattt
     7201 tgggagatgc aaccactctt accaagcatg cgttctaccg gaaattaatt acatatatca
     7261 aacaaagcag cctatcataa aataagagag cctccttcag tcgaaggaag ccccacttac
     7321 aaacaaaaca aactatatta ttttcccaaa taccaatctt tgtcctttgc tccattagac
     7381 tcagcccagg agacaaaacg gggataagtc ttgtctactg cctccctttc ctccgtcgaa
     7441 tagacctccg catcagataa gttgattgca aacggatatt ttgaagcaga tacataataa
     7501 atcccagcat tcaaatcgga taaatcctca cctgtatgga acaaggcttt cttcgctttc
     7561 tccgtaggtt tatgattgac taaatgtact tctgtccggt catatcccgt atacttaaaa
     7621 acgctgataa atggattata tggagctcct cctaagacct cgtgatcgac gggagtctta
     7681 aatttattcg tgacattcac tgttgatgtc ttcgtattat cacctgtctc agttttaaca
     7741 tccacaaata ccggaatagt agcaagagcc aaatccttat ctacctcaag agacgattcg
     7801 acattcgatt tatctgtatt taactgataa ataaaactat tgctataaga ggctccggac
     7861 cacaatacag tgaacgtgtc tttcgtagaa agcacttcat tctttgtatt aaaacttaat
     7921 acagaattgt attttacaac tacatcattc aaatcgtaat cccctttgga cggccagtta
     7981 tcctcaaaag ccaaaatacc tttgtaggtc atactatatg caattgaact atcgtcagga
     8041 tctccgggag gaataacctc aggcaaatcc ggagtaacaa tagcttcaat agggtctgac
     8101 catacattaa acatcacgtc attataatcc tggtcagtcc agtcttcaaa agagagaaca
     8161 acaaaatcat taattctaaa agcaacagta tgagtacgtc catcagtatt caactttgga
     8221 gttgagtaga acattccttt cccttcacca atatttcctt tccaaaaagc tgcattccta
     8281 atgaaccagc ctatttttat acctttagga aaatctgttc cacgatccac cccattttca
     8341 tcaatataat gtaacgcgac acattcccct ccttttagcc ctattccagt tcttgtatta
     8401 ggaaaaacaa tatacttctt ggctttctta atttctccaa tagaagcatc cgctttgtaa
     8461 caataatatc caaatgtact gtaagcgcta ctcttgccgc caataaaacg tacctttaca
     8521 tgggcaggct cttttatttc aaaatcaacc gactgacgat atttttgcgg acatttccca
     8581 tcttccggaa gtgtacggtt tattgcattc attattggtt gagacaagct tagcgctccc
     8641 tcactatcca aataatcagg acgaccattt tcatcccagt cacccaatat attaaaagcc
     8701 tttggatacg taaaattact ttccactcgt gttggagccg cagaaacaaa atcatacata
     8761 gtatcccagg atatatcagc ttgaatctta tttccctgaa gagttgtctt ataaagcgta
     8821 ggcactccga tataagaaga ataaatataa atgtcaccat ccaaataacc gggaatcact
     8881 tccaagccgg catatttacc atttccatca gtcattctag tcactttcgg cacaacatca
     8941 gtacgtttta caacttggcc ttcttcatct atttcaaatg gattctcaaa atagacatca
     9001 aagagtactt gataaccttc aggaacctca tactgcacat ttaactgtac ctgttgagtt
     9061 gtactgtaat caaagtcatt aggagtttgg gggtcatccg gacgagaata gtctgtatct
     9121 ttatcgatac aacttgcaat aacaatacca agtaaggcat aaacaactat tactttcaaa
     9181 atacatgaat agcttctcat ttttaaaatt tgttttagtt tgttgaagca aagataaata
     9241 caaacttgca tatcttatgc ataattctaa tattttttca ataaaagacg aaaatatata
     9301 ttctccaacc tttcgtgaag ttataaaata taaccatatt tactgttttt cagactcaat
     9361 ctccccttga gcaactccgg caggagttga tgcaatccta gtgcctacca caacaccaac
     9421 gttcagatat ttatggatga gaggaatcaa tcctaaaaca tgcacctatg ttgagcatat
     9481 caaaaagaag ccccctttct cacgaaagag gactcccatt tacaaacaaa acaaacaatg
     9541 ttattttccc actaaattct gttccaaaag ctctgtctta aattcaattt aacgcatact
     9601 ttttcctgct acagaataaa attctgcatc atatcaacga atcactaatg gaacacgaaa
     9661 tataaaaagg acttgaaatg gtattacagc taccattcgg tagagaataa cttaaatatc
     9721 ttttaatgta acattctgat atactattta ttaaagaaga aatcatcttc atacgtatcg
     9781 atcttctgta agtaaaaagt ttcttcattg cctattctgt tttatttgtt gccgtaaagg
     9841 taatcataaa tgctcttttt cacctatatt atcagtatct tttaatcttt ttttctactt
     9901 tcatcctttt tctattactc aaaagaccgg tatctacata gaaaaggcgg gaaaatacgc
     9961 ttttcccgcc ttttgaaaaa cttatatagt ataagtctga ttaattattt tccggacgaa
    10021 gtttacgaac tgtcacggca gtctgccaca tttcgctttc gcgcaatgct ttcagttctt
    10081 cttccagttt ctcacgataa tccggtttgg agttagagtc gattgaaatc tgtgcttcgt
    10141 taccagtctt cacactgtga tacaactttt caactaccgg tttgatagca tcgtggaagg
    10201 ggcccatcca gtcgagagca ccacgttgag ctgtagtaga gcagttagca tacatccagt
    10261 ccataccgtt ctttgcaaac aacggcatca atgactgagt cagctcttct acagtttcgt
    10321 tgaatgcttc ggaaggagtg tgaccgtttt cacgtaacac ttcgtattgt gccagcaaca
    10381 gaccctggat agctcccatc aatgaaccac gttcgcctgt caggtcggaa gtagcttcgc
    10441 ggatgaaagt tgtttcgaac aaataacctg aaccgatacc gatacccaat gcgattgttc
    10501 tgtccatagc gttgcctgtt gcatcctgat agatagcgta tgaagagttc aacccgcgac
    10561 cttcaaggaa catagtacgc aaggatgtac ccgaaccttt aggagcaacc atgattacgt
    10621 cgatatctgc aggaggaact acacctgtgc ggtcactcca tgtaatagca aaaccatgag
    10681 agaaataaag agcttttcct gcagtcaggt aaggcttgat agtaggccat acagacatta
    10741 ctgctgcatc agacaacagg cacataatga tcgtaccttt ttcgcaagct tcttcaatac
    10801 cgaacaaagt ttcacccgga acccatccgt cagcaaccgc tttgtcatat gtctttccct
    10861 ggcgttgacc aacgattaca ttgaaaccgt tatcacgaag gttcagagcc tgtccgggac
    10921 cttgtacgcc ataaccgatt acagcgattg tttcattttt caatacttca cgagcttttt
    10981 ccaatggaaa ttcatcacgg ataactacat tttctacagt tccgccaaaa ttcaactgtg
    11041 ccattttttt tgtttttttg ttttgatgac ttgcgccatc tgttattaat tgattttata
    11101 ctctatatta ttcaaatatc actttggaac ggcatactac ctcgctgccg tttttcttca
    11161 cctctacatg aaactcgttt tcactcacct catcacagaa gaaagagagt tcatttccga
    11221 aataactttc agccacatac gccatttcaa accggcggat acgtttcgtc tgatacagtt
    11281 ctatcggaaa caagtcaagt atgtgctcga tataacgaat actgtttacg tgtccgttaa
    11341 tatcgatatc actgtatttt gccgtcagcg tcgcaacagg ctgattgctt gtcaccttga
    11401 tacgcgaagg cttttctatc gggcagggtt catcgcatat ataatcgacg atgcttcctc
    11461 catgcaatgc caacagatcg gcaggcttac gagtattcag attgatcatc gcccatacgg
    11521 aacgggcata gccgatcttc tttccatcct tgtcaatgac ggcaaagtta cggtcggtaa
    11581 agagacgata gacattctcc acccatgtct gaaccgagaa cttctcgtat tggtaaggca
    11641 tctcgtccag ctcgatcgcc agacgggaaa gcacccatgt gtaattgtcc tcgttcagcg
    11701 tagcaatacc aaatccacgg tcgctggcat gaaaacctgc gcaattcagc agatgattcc
    11761 ccagcacgcc catggtcagg cggccgttaa aatctacgtg aaacggctct gccacaaact
    11821 gataagtccc tattttattt tcttcactca ttactcctgt tcctttttac tttgcttata
    11881 cttcgcttcc tgtccgtcca ggaactcatt cacacgttcg aaacagctgg tagtaatagc
    11941 cacacggccc gaacggacaa attgcagcac acatttcaaa gcccgaagtt cttcgtaaag
    12001 ggaagtaatc tcttcactca tgccgttctt ctcgacgata gagaataccg gattcacctc
    12061 tacaatgcgg gcattatatc tgcggatcac tttagatgct tccggagtct cctgaaaagc
    12121 aggagtagat accttatata aggctatctc atggaaataa atctcgtctt ccgtaaaata
    12181 gtgcgcctga atcacatcaa tcttcttttc gatctgcttc accacctttt cgatagtgtc
    12241 cttatcagtc cacgctgtaa tcgtatattt atgtactcct ttaatggaag aagcagaaac
    12301 gttcaaactc tcgatgttta tttgccgacg ggtaaataca gcggtcacct gattcagcaa
    12361 tccggctata ttttcagaat gaactataat cgtatataat gtcttatcac tcataacttt
    12421 ctaaattaag gattaacatt ccagcaacat ctgattgact gaaccgcccg gaggggtcat
    12481 cgggaggaca ttgccttctt ctaccacaca ggcttcgagc aggaacgccc cgtctgtcga
    12541 gagcatttcg tcgatggccg ctttcaattc ttcccgtgaa aagacacgtt tggaaggaat
    12601 atcgtaggcg gaagcgattt tcatgtaatc cggattcagc atcggagtaa atgaataacg
    12661 gcgattaaag aacatagcct gccattggcg cacgttgccg agataattgt tgttcaggca
    12721 gataatcttc accggagctt tctgttccat gatcgtaccc agttcctgaa tgttcatttg
    12781 cagtccgccg tcacccataa atacacatac agtgcggtcg ggacggccga aagtagctcc
    12841 gatagctgcc ggaaggccaa aacccatcgt gccaagtcca cccgaagtaa cgatactacg
    12901 ttccctggta tatttaaagt agcgggcaga gatcatctga ttctgaccta catctgtcac
    12961 caatatggct tcgtgacggg tcgcttcgct taccgcacgc accacttcgc ccatactcag
    13021 tgaatccgtt gcaggatgaa gttcgggacg aatgactttt tcttcctcta ccgcttcata
    13081 ttccttgaaa ctatcgaccc actcggtgtg ccggttcttt ttcaatagtc cggtcacagc
    13141 agccagcgtc tttttgcagt cgcccaaaac ggcaatatct acctttacat tcttatttac
    13201 ttccgccgga tcaatgtcaa aatggatcac tttcgcttgt ttggcgtaag tagctagatt
    13261 accggtcaca cggtcgtcga aacgcatacc gacagcaatc agtacatcac atttgttagt
    13321 attgatattc ggtcccagat t
//
