LOCUS       gnlProkkaNDLLCADB_28   10524 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NDLLCADB_28.
ACCESSION   gnlProkkaNDLLCADB_28
VERSION     gnlProkkaNDLLCADB_28
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:30:57
            Original ID  :: gnl|Prokka|NDLLCADB_28
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10524
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10524
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1889:6203]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1890..6203
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10524
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10524
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(2..109)
                     /locus_tag="ctg28_1"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRT"
     CDS             complement(63..1547)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_2"
                     /sec_met_domain="Polysacc_synt (E-value: 1.2e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             complement(1750..1893)
                     /locus_tag="ctg28_3"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             complement(1890..3011)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg28_4_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_4"
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(1914..2921)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg28_4_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg28_4_Aminotran_5.1"
                     /locus_tag="ctg28_4"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(3021..4145)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.2e-21, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8e-21, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(4162..5463)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_6"
                     /sec_met_domain="CTP_transf_like (E-value: 1.7e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.7e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(5484..6203)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_7"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.4e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(6267..7415)
                     /locus_tag="ctg28_8"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(7426..9837)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg28_9"
                     /sec_met_domain="Poly_export (E-value: 9.2e-19, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(9855..10223)
                     /locus_tag="ctg28_10"
                     /transl_table=11
                     /translation="MDAIILQENIEGLLSLVRMLLPGGGSAGCVYLDDLSALQGSIHEK
                     INDLYSQRGETPEQDATLCLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLL
                     KQQLSAVCHGMQELCEIN"
     CDS             complement(10234..10524)
                     /locus_tag="ctg28_11"
                     /transl_table=11
                     /translation="MRYMVMRGESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGE
                     KVRVIKGPLTGLVGELVNVDGRSKIAVRLNMLGCACVDMPVGYVEPIMAAV"
ORIGIN
        1 ctgttctaca attaggatga ggaataaaat acaatgatct actatcaact ggcacacaat
       61 ggttaattat ctttactatt acttgaaaaa tcttttttaa tattttcatc tatgttttta
      121 gttttaatga tcaatgttaa aatacaaaaa aaagaatcta gcttaaaaag aaaagaaagt
      181 aaaatataga aggacatccc agtaatacat ccaatcacaa tttttactat atcagtttca
      241 aagaaagaaa tacatataaa aacgatcccc cccattatga aagagagtat taaacttgga
      301 aatacatctt taacttgcaa ctttaaggtc aaatcaataa gagaattagt ataatatgta
      361 ttcaaatatg tcgctatcag agagtaaata actctacccc aacacatcac ctcaagccca
      421 aatggaattg acacaaaaag aatgaatata gcaatcgtct tttttattat ttcaagacgt
      481 aacgacagat cagatcttcc tttaacccat aataaattca aattaatttg gctcaaatga
      541 tcaaacatcc aatccaaaca taatatctgt aaaagaataa caaccccaga ccatttatct
      601 gttaacaata gactaataat aggattagcc aaaacaagta aacctaccat taaaggaaaa
      661 attatatatg aggataatct gatataattt cgatatgcgt ttgttaaaca tttatcatca
      721 tcttgaatgg aacttaaaat aggatacgct actctagaaa ctaaagcatt taaattattg
      781 gaaggaaaaa tagcaaattg ttctgctctt gtatagtaac caagctctac aacagaaaac
      841 ttttttccta ttacaatggt atacagatta cgatatactg tattgataag acttgagatc
      901 aataatttag atccgaaatt gaataatctt tcaaaagaac ttttggagaa agtatgtaaa
      961 ggtttccaat gaactaaaca gtaaaacaaa attgtcaaaa ttatactatt taagagagtt
     1021 tgccaaacta aagcccaaac cccgcaaccg acataagcca tccatattcc aatcacgcct
     1081 gatataaaag ctgcacctaa tgaaatttta gattgagttt taaagtttac agaaataatt
     1141 aatttcgttc tgtgaatagc cgataaagca tttattatca acgacaatgc tataaaacga
     1201 attacaagaa ctaaagtcgg catattataa aagtctgcaa tcaaagaagc cgaaaaaaac
     1261 aatataccat agaataatac tgcgacaaga atattaaaat aaaagacagt ggcaaaatcc
     1321 tcttcagttc tatctttttt ctggattaaa gcatttgtaa aaccgctatc tataaatact
     1381 tgagcgactt gaagaaaaat agctaacatc ccgatcatac cataatccga tggtagtaac
     1441 aaacgagcta atattatttg aattataaac tgtactcctt gtaaagagaa acgttctata
     1501 gcgctccaca ttattcctga tacagttttc tgctttagat tttccattac ttaaatacag
     1561 tataaaaaca actacattta ccgatatcaa ttatattttt ccaatattct cactaattgg
     1621 ttattatctt cttcgcccct taccgcaatt ctaatatggt ctctcccact aaaagcaaat
     1681 taccctacac aaacattatc tcctataact accgatgcct ttttataaga ataaagaact
     1741 cctaatgcat cacctcaaat taatattgcc atatttgcct actaagcgaa agctacgaat
     1801 aggcactcca gaaataacac tttccggatg gaagtgtata ccacgaaggg aaaaataaaa
     1861 atgacgaatc ttcaataata tttctgcaat catgacatcg gtaatgtgac gttataatga
     1921 tttaatgcag cttttagtac tttaaagaag ttctcaatat catctacttc tatctctcct
     1981 aaagcacaga ttctaaaagt atcctcagtt gatatcttac ctggataaat cgtaaatcca
     2041 cgctcataac aataatcatg tattttctca aaatcccagt tgggatcttc tgggtattga
     2101 actgagacaa ccagtcctga ctgccattca cgctttatta cacttttaag accaatttca
     2161 tttatacctg aatgaatagc ctcaaaaact cttttgtgac gggcaaactt agcttcttca
     2221 cccacttcaa aatattcatt taatgcctga cgagtggcgt aaatagtttg taccggtgga
     2281 gtaaaatgca tttcacctgt tctctcaaaa ttctcatact gcaaataaag attacaatag
     2341 taagaacgct tgggatattt ttttgaaaac ttaatctgtt cctcattgcc tataataaaa
     2401 gaaagacctg tcatcgcttg aagtcctttt tgagcagatg ccatacaaaa atccacatta
     2461 tctttctcta tatcaaaagg aatcatgccc aaagaagaag tagtatcgac gacaaattta
     2521 gcctgatatt tatgagctat agcgcccatc tcgcgaatag ggttcagaat tcctgtaccc
     2581 gtctcgtgat gagtagtata aaccatagct atatcaggat tttcttgcaa cacattttcc
     2641 accaccgata aatcaggacg ttcgtaaacg gaaaattcca aattaatatg aggcaaacca
     2701 taatattgac acacttctac agcacgggta ctatatgccc cattattcac tataagcacc
     2761 cttttgtctt caggaagaag agaatttaga catatatcaa tattgatggt tcctgagcca
     2821 caaaataata cagcggtatg tttttccaaa ttcccatgag caactctgac caaatcgtcc
     2881 cgaagttgtt tcatcatacc tgcgaattct ttctcgcgag gacaaatatc cggaacaact
     2941 tgtgccattt ttacactgtc agtagtagtg gcaggcccag gatttaataa tatttttctt
     3001 tctattttca tcgaatatat ttattttaaa aaatccataa aatgctcctt attctctata
     3061 ggagtagtcg tgggacgtcc caaattctcc cgagaatcta ttttaacctt tatttccaac
     3121 aaaacaggac cacataactt tggaagctgc ttcattgctt cttcaatttc aacttttgta
     3181 caaacagtat aagtatgctt atatccgctc ccccggacaa tagccggaat atctaaacta
     3241 aatcctaaag taggctgtcc tcctacagac tcgtgagcac cattgttaaa caaaatatga
     3301 taatagtttt taggagataa atcgccaatg ttactaattg cccctaaatg cataataaat
     3361 gctccatcac catccaagca ataaacaggt ctatcttgct ttgctatagc aatacccaaa
     3421 gagattgatg aactatgtcc catagagcct accgtgagaa aatcatgttc atgaccttgc
     3481 tctttcattt ctcgatattc aaataactca cgagaaagct tgccagtagt agaaacgacc
     3541 actgaatttt caggcagata atccacaact atttgcaaag catcctcacg agataaagga
     3601 taattacatc cgaactcttt ttgaagttta tatttgccaa aaacatcttt ccgaataatt
     3661 attgcatgag gaatattctt agtttttgct gattgtatga tatcatggag ctgaataaat
     3721 gcatcattct catttgaatc aagaattata taaggaatcc gcattgcttt caacaaatct
     3781 aaagttacct caccctgttt tttatgctga ggttcatctt ttgttcccgg ttcaccacgc
     3841 cagccaatca tcaaaagcat tggaaaactg tatacttgtt catctgcaag agacagcaga
     3901 ggattaacag tattacccaa gccggaattt tgcatataaa ccacaggaac cttacctgat
     3961 gccatataat aacctgaagc aattcctaca gccgcacctt cattagcagc tatgatatgt
     4021 ttctcacgtg aagtatggtc tgtgatatag gcacaaatat tttttagtaa tgagtctgga
     4081 actcctgtaa aaaaatcaac gtcatgactc agaaacgttt cataaacttt ttctacgctt
     4141 aacataatga tattcctctt tttatttagt acctggaatc agttccaata tttcttttat
     4201 gggcatacac agttcgcgca cctctaaagc acgttcattc tctaatatta tctttgcgac
     4261 attcatcata gcaggataag cggcacgaag catatgatta gcataaataa ttatattcac
     4321 accccaatca cacaattcag actcataaat atgatcatat gtagtaggca caaccacgat
     4381 aggtacatga gcatactgtt ttcgaaacgc caaacaaaat tcttttatat cttcacccga
     4441 cttatttttg ctatgtatca taataccgtc cgctcccgct tggacatatg caaaagctct
     4501 ctctaaagca tcacttaccg gctttcccgc tataaggctc tcaatacgag cgataatcat
     4561 aaaatcatca gtaatctgag atgcctttcc tgctttgatc ttattacaga aaccttcgat
     4621 tgtatcttga gtttgaataa catctgtacc aaacaatgaa ttctttttta atccaacttt
     4681 atcttcaatt attatagctg aaattccatg acgttctaaa gtgcgtactg taaatacgaa
     4741 atgttcaatt ttaccacctg tatctccatc aaaaataata ggtttagtag tacactccag
     4801 aatattattc aaatcttgca atcgggtagt taaatcaacc gcctcaatat caggtttacc
     4861 tttactggtt gaatccgtaa ggctactaga ccacattccg tcaaatactt ccctcttatc
     4921 cccttttaat atttcctgat tttcaattat caagccacat agtccatcat gagcttccaa
     4981 aatacgaact acgggtttgg catttatcaa acgacgaagt gattttaaac gtacatcagg
     5041 ggttgtacct atagccttaa tatctttatc caaagaagat gaattaattc ccaaagtata
     5101 tggaatttcg ataacctttc ctccctgttc attcatcact tcaaatacgc gcacacgttc
     5161 ttcacgtaaa ggcccggttt tccagtcgtc accatgaatt atatagtcag gtttaatgcg
     5221 tttgagattc tcaacatagc tccattcttc ttgaggaaca actttacata cgcctttaat
     5281 attctgaact acctcttttc gttgttcata ggtcagataa ggaaggcgtt tatgctccgc
     5341 aatagcttta tctgtaagaa gaccaattat aacatcaccg tatttagtag cctcattaat
     5401 aatgcggata agtcctggat gcataatatc cgcagtcatc ccaatataaa ctgtcttact
     5461 cataatttga tatattattt taattaacaa tacggaacaa tatatttctc tgcatattcc
     5521 aaatctgata tgtcatcgat ttcataccat ttcagccctt ctactttatg cacataaaca
     5581 ggagattgag aacaagatat tcgtagtaat tcatactcat atcccaaatt gggttgttca
     5641 tcaacaatac tcgcataatc agcacacatt attttgtaaa aggaaccgga tagtttatgg
     5701 atgccgacca attcgccttt agcgtttagt ttattcttat tgacagaaca tgaagaaagg
     5761 cgaaaattat catcatgttc cacataatac tgatcttgaa actttgtcac tggagttatt
     5821 agcattgcat ctgccgcagg acactccaat aagctcatta ttgcttgttt ctcaaaaatc
     5881 aaatctgact ctaacaataa aaaatcatca ttgcccagaa tctcccgcgt attatataaa
     5941 gtatacatac tatttgtttc agcataacga ggactaaaac aggtttcaag cataggatag
     6001 tctgtcttca attcttcata aacttcttgt ttatatcctg taccgattac aattcgctca
     6061 atgtcacatg ataacaaagt atcaatagaa cgaactatca ttggaatacc tcccactttg
     6121 acgaaccctt taggtatcaa ttctgtatat tggccaaaac gggttcccat gcccgcagcc
     6181 attatcatag ctgtacgtat cattcgttta ataatatagt aagtgaattt aattgatgta
     6241 agaatgttgt aaacgacgtt ttagcatcat ttatcctgtt ctatctcctt atttttcagt
     6301 tcttttctca agctagccag cagacttttg ccaaaaaaca cccacacgag agtaccagat
     6361 acggacagga acacaaataa taaaatataa attttgagtc ccatacctga aggtttcaaa
     6421 ggtacaacgg caggctcaac tactgcaaag actggctttt cctcctgtac tttggctctg
     6481 gatacctgca actgattagc aacctgacta tatatctgat aagccaaact catgtcgttc
     6541 tgtaaacgct cctgctcagc acgtacactt tgaagaacca cattatcatg ggcgtctaca
     6601 taatccgcat attttctttg agcagcataa tattcctgct gacgttcttt aaacaaccgt
     6661 tccaaatacg cacagtcttc ttttactttt gaagttcgat acccaataat atattcctgt
     6721 aatttatgaa cgacagaatc tgctataacc gcagtgatct gcggattttg taaggtgacc
     6781 gtaatgctcg ttatggcggt tttcttatca atggatgcac taatcttctt tttaagaaaa
     6841 ttaatcttct catttacttc tttcgtcaat tcgatagttc cttgccgccc tccactggca
     6901 ggaaccgtat cttctccgaa taatgattta actcctccta ttactatgcc cggaaaacct
     6961 ataagataat cccaccaagg agatgactct tcatcgagat aagaccccaa agtcatttta
     7021 tcatcctttt tagaaacgga gacttccatt tctaaaagtt ccaataaaaa aggagttgaa
     7081 gaaacaatat ctgctgaaag agaagcgttc aaggcatctg tgctttcccc tattagagcc
     7141 ccatctccca aaaacgaggc agcaagtccg gctaaaccat tacttccctt cgcattaccc
     7201 atttcaggag aaagggtaac ctttactgta tattgcttgg gaatgctcaa tgccaccact
     7261 atagcaatta ttactcccac tccagcagct ttgcatagta ctccacgaac agtaataatc
     7321 ttataaaaaa tagccatcaa gtctatttcc atttcatcat ctttcctttt atccacttca
     7381 gaaaacggtt cttgataaga ttgcttttca atcataatag gtcatttatt tctttatcaa
     7441 attagcaata gaagcaatca tcattcccaa agaactgaag gaagtagcat aacctaaaat
     7501 attagctatg ttccctttct tcttagcctt accaggcaca ataatctcac accccggctc
     7561 aatctgtttc ttaccactac ccttaacctt cgtcacctga ccattcatgt aaacaatgaa
     7621 cttcttactc ttccttgcat tatcagaaca gccaccggcc tgattcaggt aataatccac
     7681 attctttccc ttcatataag aaaccgtatt cggaaccatg acagcaccat tgatagttac
     7741 agtattagta ttcttaggta tggagatcac atcaccttca cgtaagacaa gatcggcatt
     7801 acttttagga ttgctcaagg ctttttccaa atctattcca accgtaaaag tatcttcaac
     7861 acgaataccc aaagagtcaa tcatggcttc gcccaattgc ctgctcataa ggcgaattac
     7921 atcacccata cgtttctttt cactagcgtt agccacacgg gtcagtttcg caccacgcag
     7981 ataggcataa ttggtcggac cgccggcttt attcactaaa tcggaaagac gttcctcacg
     8041 gctggtcatg gcgtaatttc ctccgaaaag gatttcacct tcaatggcta cattctgttg
     8101 tgcctgatag cccggactgc gacggacata aacctgatca taaggctcaa ggataaaacc
     8161 gggctgacca tctattacaa aaccatcctt taaagagaag gtatacatct gaccaatcgt
     8221 atcattatcc gcagtactac gaggattctt gattcgtctc gatatatcaa tacggacagt
     8281 agaggcggct tctttcaagc caccggcctg aatgatcaga tcctcaagtg tcatgttatc
     8341 cgcataagga taggaatcag ggtgggcaac ctcaccgtga actgtgacat taccccggtc
     8401 ttccaggtca tggatacttg gaatgtagag gatgtcattc ttcattaggg caaggtttgg
     8461 ggaagtgccg tccatgatag acttaatgtc tatctgaaca acttcactgg tcaggtcttc
     8521 acgctggcga tagaggacgg cacgattcag gaaagcgtca ccggtcagac cctgagcttc
     8581 atggacaagt tcgcggatcg tgttcagttt accgctgagc tggtagatac cgggacgata
     8641 gacagcgcca cggatttcca gtttgtttgt gaagcggtta aggatggctt cggcggttac
     8701 tacgtcaccg ttacgcattt tataaatgtt gtaatctata tctttgactg tgttgacttc
     8761 gtattcctca ccattctgac ggacaacacg taatgaacgg gtgtaggcat cagcttcaaa
     8821 gccgccggca tatttaatga gagtagcaag gttctcgtct ttcttcattt caaaacgcat
     8881 aggacgtttt accttgccgc taatctttac caatacatca taggcaggaa caatcacaac
     8941 gtcaccttcc tgtaggcgga tgtcatcctg tgtgttgcct ttcataatga attcgtagac
     9001 gtcgatggtg gcaatattct ttccgttgcg taccaactga acgtttcgga ggctaccgat
     9061 atcactcaca ccgcctgcac gataaagcgc atggaagacg gtagagaagg aagaaagggc
     9121 gtaggtaccg ggctgtacga cttctcccat cacattaatc tgaatagtac ggatattacc
     9181 taacgtcaga cggatgtcgg aagtaggatc ggtagtatta ttcagaccgt tatatatttt
     9241 attcagggcg ttcttcagat agtcattggc ggcagagact gtcataccgc taaggttgac
     9301 agggccgatc ttctgaatgt tgatagtacc ttcaggagag atttgctggc ggatcgtgtt
     9361 ctggctcgca ccccagatat caatgatgac ttcatcaccg ggaccaagac ggtaattggc
     9421 aggagtggca aggttgacac taggctcgaa cgtcaggttg cgggtattga agatgttacg
     9481 tccgaagacc tgatcaccac gggcaaggtc ctgagtagtc ggatgatcct ccagcatatc
     9541 ggaagtattc ttcttagtct cttcacgcag gcgggattcg ttgatgtccg tgcccgttga
     9601 tttcgaggta tttacattgt tctgctgctc gtatagctgc ttcacacgca ttgcctgttc
     9661 tttggttaca cccttacggg ctagttcgga agcaagctgc ttctgttcct tgccttggcg
     9721 gatgccgtct tttacatatt ccagtacctg tgagtcactc atggactgag ccataagcga
     9781 gccacttccc agcatcaaac aaaatagtag aatgctaaaa agtcgttgta ttttcattga
     9841 caaataaaaa agtttcagtt gatttcacac agttcctgca tcccatgaca gacggcagat
     9901 aactgttgct taagaagaga agggggaaga acatcgagaa gagacagaga acgggtcaaa
     9961 acagcctgtt ttctttcttc gtcttccgga ttggcgtaca tcgacacatt atatccctga
    10021 aggatggcca aacacagggt agcatcctgc tccggtgtct ccccccgttg agaatataaa
    10081 tcgttaatct tttcgtggat ggatccttgt aatgctgaaa gatcatccag atacacgcag
    10141 cctgcactcc ccccaccagg aagcagcata cgtaccaaac ttaataaacc ctctatgttt
    10201 tcttgtaaaa taatagcatc catatccctt gccttaaaca gccgccataa tcggctctac
    10261 ataaccgaca ggcatatcaa cacaggcgca tcccagcata ttcaagcgaa cagcaatctt
    10321 acttctgcca tccacattaa ccagttcgcc aacaagaccc gtcaacggac ctttaatcac
    10381 gcgaaccttt tcgccacggg ccaaaggaga actgttcatg cttatcgatt cttccgaata
    10441 atcaagcatg aaacggaaac gagccatctg ctcgtcagga attacagcag gactactctc
    10501 accgcgcatc accatgtaac gact
//
