LOCUS       c00129_gnlPro..        15708 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FDKCFOPL_129.
ACCESSION   c00129_gnlPro..
VERSION     c00129_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 19:31:16
            Original ID  :: gnl|Prokka|FDKCFOPL_129
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15708
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15708
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:5708]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..5708
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15708
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15708
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..772)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_1"
                     /sec_met_domain="IlvN (E-value: 4.3e-47, bitscore: 150.7,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 9.4e-18, bitscore: 55.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFA"
     CDS             complement(836..1501)
                     /locus_tag="ctg129_2"
                     /transl_table=11
                     /translation="MGVLGNHLLNCAGFHASDRGFGIATLNEDNYTWVLSRLAIELDEM
                     PYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGKKIGYARSVWAMINLNTRKPADLLALH
                     GGSIVDYICDEPCPIEKPSRIKVTSNQPVATLTAKYSDIDINGHVNSIRYIEHILDLFP
                     IELYQTKRIRRFEMAYVAESYFGDELSFFCDEANENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             1879..2127
                     /locus_tag="ctg129_3"
                     /transl_table=11
                     /translation="MEINLVFRKIVRLNHINLLFDLLHHLFNSVLISPRCDRIFMYSFN
                     GRSRNVQTLDVYLPTGKYSGHLIQQSGYIFRMNYNRI"
     CDS             complement(2161..3858)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.6e-47, bitscore:
                     149.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTQQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNHRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKVAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(3906..5708)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_5"
                     /sec_met_domain="ILVD_EDD (E-value: 1.1e-217, bitscore:
                     714.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGG
                     LIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRLID"
     CDS             6183..6758
                     /locus_tag="ctg129_6"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTVEDGEKELFEETNAEHPFQFISGLGTTL
                     ESFENQITALSKGDKFDFTIPADEAYGAYDEQHVFDLPKNIFEIDGKFDSERVTEGSIV
                     PLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEVIESRPATNEEIQELVKMM
                     SGEGCGCGCDSCGSDCGDDCGCEGGHCH"
     CDS             complement(6890..8179)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg129_7"
                     /sec_met_domain="SDH_alpha (E-value: 3.1e-62, bitscore:
                     201.5, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIESERKQIIDLIKKEVIPAIGCTEPIAVALCVAKAAETLGMKPE
                     KIEVLLSANILKNAMGVGIPGTDMVGLPIAVALGALIGRSEYQLEVLRDCTPEAVEQGK
                     LFIAEKRICISLKEDITEKLYIEVICTAGSQKATAVIAGGHTAFVYIATDEKVLLDKQQ
                     TANEEEEDASLELNLRKVYDFALTSPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKTEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SIRNLTRIGSQAMNETDKMVLDIMTHKGGC"
     CDS             8433..9398
                     /locus_tag="ctg129_8"
                     /transl_table=11
                     /translation="MTTSPIITNNSINIFVGPGTDISSLAPEFTLTPGATIDPPSGTAR
                     DFHSPQQYTVTAADGFWKKKYTVSVIDTELATIYNFEDTLGGQKYYIFVEREGEKVVME
                     WASGNAGYAMTGVPKTADDYPTFQFANGKTGKCLSLVTRSTGFFGSIMGMPIAAGNLFI
                     GSFDVGNAMSNPLKATKFGLPFRHIPTYLAGYYKYKAGDQFTEGGKPVSGKRDICDIYA
                     IMYETSESVPTLDGTNAFTSPNLVSIARIDDAKETDEWTYFKLPFHMLSGKYIDKEKLT
                     AGKYNVAIVFTSSLEGDHFNGAIGSTLLIDEVELIYRSED"
     CDS             9489..10274
                     /locus_tag="ctg129_9"
                     /transl_table=11
                     /translation="MKIHSYIFSLLACLVIALPGYSQVDRNETLIRSALHGLEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWFAVQNKLGVIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTSGLTIPLMATYKLSNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREGDPVGPKVEFTDGKIATYDFSDDLRHFQWGLQIGAGWRAFKH
                     LNIYADLTWGLNDIFRNDFQTITFAMYPIYLNIGFGYAF"
     CDS             complement(10290..10853)
                     /locus_tag="ctg129_10"
                     /transl_table=11
                     /translation="MKKNLLYLWALICSVSLLTACSSDDDNTVNDETTPPEEEAVVTAP
                     DVVGTYWGNLDISMLPDGSDQEVVIADGLPKFITFSQVSDTEVKMELKEFELFINGNIL
                     KFGDIVIDKCAVKKETDVSTFTGQQDLTFQGDAAALGTCATSIEGTVQSGNATMNIQVK
                     VPALKQTVKVAFSGVKQVEESGKD"
     CDS             11012..12088
                     /locus_tag="ctg129_11"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGVGGVIDGFPAGITIDEEFVQQELN
                     RRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHSNDYNNLKEVYRPS
                     HADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGISITAYTSQVGAIKL
                     EGTYSDYDLDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQ
                     PVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFFNNNGRIETHTNHSGG
                     IQGGISNGQDIYFRVVFKPIATLLMEQETVNIDGVDTTLKARGRHDACVLPRAVPIVEA
                     MAAMTILDYYLLDKTTQL"
     CDS             12190..13554
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg129_12"
                     /sec_met_domain="Peptidase_M20 (E-value: 9.9e-39, bitscore:
                     124.1, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIQKYIAANEPKIMEDLFSLIRIPSISALPEHHDDMLACAQRW
                     AQLLLEAGVEEALVMPSKGNPIVFAQKIVDPNAKTVLVYAHYDVMPAEPLELWKSQPFE
                     PEVRDGYIWARGADDDKGQSFIQVKAFEYLVKNELLKNNVKFIFEGEEEIGSPSLEAFC
                     EEHKELLKADVILVSDTSMLGAELPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVAN
                     PINVLCEIISKVTDKDGRITVPGFYDDVEEVPQAEREMIAHIPFDEKKYKEAIGVKELF
                     GEKGYSTLERNSCRPSFDVCGIWGGYTGEGSKTVLPSKAYAKVSCRLVAHQDHHKISQM
                     FADYILQMAPDTVQVKVTPMHGGQGYVCPISLPAYQAAEKGFEIAFGKKPLAVRRGGSI
                     PIISTFEQVLGTKTVLMGFGLESDAIHSPNENFSLDIFRKGIEAVVEFHQEYAKR"
     CDS             complement(13676..14734)
                     /locus_tag="ctg129_13"
                     /transl_table=11
                     /translation="MKKKLTGVALVLAAVSLMGIQPAEACTRAVYLGPDGMVVTGRTMD
                     WKEDIMSNIYVFPRGMQRAGHNKEKTVNWTSKYGSVIATGYDIGTCDGMNEKGLVASLL
                     FLPESVYSLPGDTRPAMGISIWTQYVLDNFATVREAVDEMKKETFRIDAPRMPNGGPES
                     TLHMAITDETGNTAVIEYLDGKLSIHEGKEYQVMTNSPRYELQLAVNDYWKEVGGLQML
                     PGTNRSSDRFVRASFYIHAIPQTADAKIAVPSVLSVMRNVSVPFGINTPEKPHISSTRW
                     RSVSDQKNKVYYFESTLTPNLFWLDLKKIDFSPKAGVKKLSLTKGEIYAGDAVKDLKDS
                     QSFTFLFETPVM"
ORIGIN
        1 ttgcaaacaa cggcatcaat gactgagtca gctcttctac agtttcgttg aatgcttcgg
       61 aaggagtatg accgttttca cgtaacactt cgtattgtgc cagcaacaga ccctggatag
      121 ctcccatcaa tgaaccacgt tcacctgtca ggtcggaagt agcttcgcgg atgaaagttg
      181 tttcgaacaa ataacctgaa ccgataccga tacccaatgc gattgttctg tccatagcgt
      241 tgcctgttgc atcctgatag atagcgtaag aagagttcaa gccgcgacct tcaaggaaca
      301 tagtacgcaa ggatgtaccc gaacctttag gagcaaccat gattacgtcg atatctgcag
      361 gaggaactac acctgtgcgg tcactccatg taatagcaaa accatgagag aaataaagag
      421 cttttcctgc agtcaggtaa ggcttgatag taggccatac agacattact gctgcatcag
      481 acaacaggca cataatgatc gtaccttttt cgcaagcttc ttcaataccg aacaaagttt
      541 cacccggaac ccatccgtca gcaaccgctt tgtcatatgt ctttccctgg cgttgaccaa
      601 cgattacatt gaaaccgtta tcacgaaggt tcagagcctg tccgggacct tgtacgccat
      661 aaccgattac agcgattgtt tcatttttca atacttcacg agctttttcc aatggaaatt
      721 catcacggat aactacattt tctacagttc cgccaaaatt caactgtgcc attttttttg
      781 tttttttgtt ttgatgactt gcgccatctg ttattaattg attttatact ctatattatt
      841 caaatatcac tttggaacgg catactacct cgctgccgtt tttcttcacc tctacatgaa
      901 actcgttttc attcgcctca tcacagaaga aagagagttc atctccgaaa taactttcag
      961 ccacatacgc catttcaaac cggcggatac gtttcgtctg atacagttct atcggaaaca
     1021 agtcaagtat gtgctcgata taacgaatac tgtttacgtg tccgttaata tcgatatcac
     1081 tgtattttgc cgtcagcgtc gcaacaggct gattgcttgt caccttgata cgcgaaggct
     1141 tttctatcgg gcagggttca tcgcatatat aatcgacgat gcttcctcca tgcaatgcca
     1201 acagatcggc aggcttacgg gtattcagat tgatcatcgc ccatacggaa cgggcatagc
     1261 cgatcttctt tccatccttg tcaatgacgg caaagttacg gtcggtaaac agacgataga
     1321 cattctctac ccatgtctga accgagaact tctcgtattg gtaaggcatc tcatccagct
     1381 cgatagccag gcgggaaagc acccatgtgt aattgtcctc gttcagcgta gcaataccaa
     1441 atccacggtc gctggcatga aaacctgcgc aattcaacag atgatttccc agcacgccca
     1501 tggtcaggcg gccgttaaaa tctacgtgaa acggctctgc cacaaactga taagtcccta
     1561 ttttattttc ttcactcatt actcctgttc ctttttactt tgcttatact tcgcttcctg
     1621 tccgtccagg aactcattca cacgttcgaa acagctggta gtaatagcca cacggcccga
     1681 acggacaaat tgcagcacac atttcaaagc ccgaagttct tcgtaaaggg aagtaatctc
     1741 ttcactcatg ccgttcttct cgacgataga gaataccgga ttcacctcta caatgcgggc
     1801 attatatctg cggatcactt tagatgcttc cggagtctcc tgaaaagcag gagtagatac
     1861 cttatataag gctatctcat ggaaataaat ctcgtcttcc gtaaaatagt gcgcctgaat
     1921 cacatcaatc ttcttttcga tctgcttcac caccttttca atagtgtcct tatcagtcca
     1981 cgctgtgatc gtatatttat gtactccttt aatggaagaa gcagaaacgt tcaaactctc
     2041 gatgtttatt tgccgacggg taaatacagc ggtcacctga ttcagcaatc cggctatatt
     2101 ttcagaatga actataatcg tatataatgt cttatcactc ataactttct aaattaagga
     2161 ttaacattcc agcaacatct gattgactga accgcccgga ggggtcatcg ggaggacatt
     2221 gccttcttct accacacagg cttcgagcag gaacggcccg tctgtcgaga gcatttcgtc
     2281 gatagccact ttcaattctt cccgtgaaaa gacacgtttg gaaggaatat cgtaggcgga
     2341 agcgattttc atgtaatccg gattcagcat cggagtaaat gaataacggt gattaaagaa
     2401 catagcctgc cattggcgca cgttgccgag ataattgttg ttcaggcaga taatcttcac
     2461 cggagctttc tgttccatga tcgtacccag ctcctgaatg ttcatttgca gtccgccgtc
     2521 acccataaat acacatacag tgcggtcggg acggccgaaa gtagctccga tagctgccgg
     2581 aaggccaaaa cccatcgtgc cgagtccacc cgaagtaacg atactacgtt ccctggtata
     2641 tttaaagtag cgggcagaga tcatctgatt ctgacctaca tctgtcacca atatggcttc
     2701 gtgacgggtc gcttcgctta ccgcacgcac cacttcgccc atactcagtg aatccgttgc
     2761 aggatgaagt tcaggacgaa tgactttttc ttcctctacc gcttcatatt ccttgaaact
     2821 atcgacccac tcggtgtgcc ggttcttttt caacagtccg gtcacagcag ccagcgtctt
     2881 tttgcagtcg cccaaaacgg caatatctac ctttacattc ttatttactt ccgccggatc
     2941 aatgtcaaaa tggatcactt tcgcttgttt ggcgtaagta gccagattac cggtcacacg
     3001 gtcgtcgaaa cgcataccga cagcaatcag tacatcacat ttgttagtat tgatattcgg
     3061 tcccagattt ccgtgcatac ccagcattcc tttattcaac ggatggtcgg taggcaatgc
     3121 ggaaagtccg agcaaggtac aacctgcggg catatccgcc ttttcgataa agatacgcag
     3181 ttcttcctga gcgcttccca gttccactcc ctgtcctacc aagacaagcg ggcgttcggc
     3241 gttattgatc agttcggcgg cagcctttac cgattcttcg tctgtatcgg gaaccggaac
     3301 atagctgcgg ataaactcct gctgcgtcgg ctcgtatttt gttttttcaa cctgcgcatt
     3361 cttggcaaag tcgagtacca ccggaccagg acgaccacta ctggcaatgt agaaagcacg
     3421 tgctatcgcc caggctacgt cttcggcacg gcgaatctga tagctccatt tagcgattgg
     3481 ctgagtgata cctacgagat cgacttcctg aaaagcgtct gttccaagga agcctgttcc
     3541 cacctgtcct gcaatgacaa cgataggcgt actgtctatc atcgcatctg caatacctgt
     3601 gatcgtattg gttgctccgg ggccgcttgt caccaagcaa acaccgactt tacccgatac
     3661 acgggcgtag ccttgtgccg catgggcagc tccctgttca tggcgaacca agatatggtt
     3721 caatgtattt tgatggtcgt acagggcatc gaacgtaggc atgatggaac cgccgggata
     3781 accgaaaatg gtagtcactc cctgatgttc cagagagcgc atcattgcct ctgcgcctgt
     3841 tattaagtcc ttactcatag ttctttaatg gataatggat gattcataat ggataatgaa
     3901 gtggatcagt ctattaatct cactgctccc ttatcggcag agcttaccat gctggcgtat
     3961 gctttcaggc tcttcggcac gtaacggtca cgggtgacgg gagtcatcgg gcgggcagcc
     4021 agttcttcat ctgttagtcg cacgttaatc gttcgggcgg gaatgtcgat ttcgatgata
     4081 tctccatcta ctatttttcc tatattacct ccggcagcgg cttcgggaga aacgtgtccg
     4141 atactcaatc cggaagttcc accactgaaa cgtccgtcgg taatcaaggc acattctttg
     4201 ccgaggtgac gggatttgat ataagaagtc gggtaaagca tttcctgcat accgggaccg
     4261 cccttcggac cttcgtgcgt gatgacgaca acgtcgccgc tgacgactcg gcctccgagg
     4321 atgccttcac aggctgcttc ttgtgagtcg aatactttgg caggtccggt aaacttccag
     4381 atgctttcgt ctacacccgc cgtttttact acgcaaccgt cctgagcgat atttcctttc
     4441 agtaccgcca ggcctccgtc cttgctatag gcgtgctcca gatcacggat acatccgttc
     4501 gcgcgatctt tatctaattc ctgataataa gctccctgag aaccaagtac gagattgaat
     4561 ctgtttcctg ccgcacttga atatttgctc attgcttttt ccgtaacgtt cgggctggta
     4621 attgaatatt gatcgatcgc ttccgccagc gacatgccat ccacacggag aacggaagta
     4681 tcaatcagac cgccttttgc caactctgcc aggatagcaa tgatgccacc cgcacggtta
     4741 acgtcctgaa tatgatattt ttgagtattc ggagcgactt tacacaggca gggtgtcttg
     4801 cgtgacagca tatcgatgtc gtccatcttg aaatcgactc ctgcctcatg tgccacggcc
     4861 aacaggtgaa gcaccgtatt ggtagaaccg cccatcgcaa tatccagcgt catggcattg
     4921 aggaatgcct gacgggtagc tatgctgcgg ggaagtacac tttcgtcacc ttcttcataa
     4981 tatttcattg cattttccac aatcagtttg gcagcatctt caaacagttt cgtacgattt
     5041 tcgtgcgtag ccacgattgt gccgtttccc ggaagagcca agccgatagc ttcattcaga
     5101 cagttcatcg agtttgccgt aaacattccg gaacaacatc cgcaggtagg acaggcattc
     5161 tgttcgatat tcgctacttc ctgatcgctt acactgtcgt ccgccgattt aatcatggca
     5221 tcgatcaagt ccagatgctg accgttccac tctccggctt ccatcggtcc gccggataca
     5281 aatacggtag ggatattcag gcgcatggca gccatcagca tccctggggt aatcttatcg
     5341 cagttgctga tacataccat tgcatccgcc ttgtgcgcat tgaccatata ttctacgctg
     5401 tccgctatga tatcacggga aggaagcgag taaagcattc cgtcatgtcc catagcgata
     5461 ccgtcatcaa tagcaatcgt attaaattcc gcagcgaagc atcccagctt ctcaatttcc
     5521 gccttcacca actgcccgat ttcatgcagg tgcacgtgtc ccggaacaaa ttgtgtaaac
     5581 gaattgacga tagcgataat gggttttccc atctgatttt tcttcatgcc gttggctgcc
     5641 cataatgcgc gggctcccgc catgcgacgg ccttgtgtac taaacgaact gcgtaattgc
     5701 tttttcattt caatctatct tttaattaaa gagcctccct cacatcagtg agaaaggctc
     5761 caaattctat cttttatggt acgaatacat acacaaaacc tttctcacgc tcttgatggc
     5821 accaccacga cgcgaataat atgcagaact gctaggttaa tagatgtatg taatatattc
     5881 atatcttctt ttctttattt tcgtgctgca aaggtaaggg cttttttatt atctccaaac
     5941 aaatcgaaga aaaaaatcac taaaaagcga ataatcgtaa gaaaagaacg gtaataaacc
     6001 taaattttat cacttaaagg ttgaatttgc aactatcagt tagtagagaa tgactgtcca
     6061 tttctgacaa aagcgcttaa taatctgaaa tttactccgt atgcacccgg tagcaagcaa
     6121 attattcgta tctttgtcca ccctaaataa gggatttatt aattagaaac tataaatatc
     6181 agatggaaac agtagaaaac aagtacatca ccgttgcata taagctatat acagtggaag
     6241 atggtgaaaa agaattgttc gaagaaacaa atgcagaaca tccttttcag ttcatttcag
     6301 gattaggcac aacgctcgaa agcttcgaga accagataac agctctttct aagggtgata
     6361 aattcgattt taccattccg gcagatgaag cttacggagc ctacgatgag caacatgtat
     6421 ttgatcttcc taaaaatatc tttgaaatag atggcaagtt cgacagcgaa cgcgtaacag
     6481 aaggcagcat tgtacctttg atgaccggag acggtcaacg cgtaaacgcc agcgtcgtag
     6541 aaatcaaacc ggatgtagta gtagttgacc ttaaccaccc attggcaggc gctgacctga
     6601 tctttgaagg tgaagtaatc gaaagccgtc ctgctaccaa cgaagaaatt caggaactgg
     6661 tgaagatgat gagcggtgaa ggttgcggtt gcggatgcga cagctgcggc agcgactgtg
     6721 gcgatgactg cggttgcgaa ggcggacact gccactaatt ttaagtaata ggtaataagt
     6781 attaagtatt aattccatgc ggatataggc ggaagttaat acttaatact ttttttatgc
     6841 cgttattcca gctattacct attacttatt acttgttact tattacctgt taacatcctc
     6901 ctttgtgcgt catgatatca agcaccatct tatccgtttc gttcatggcc tgcgagccga
     6961 ttcttgtcaa gttacgaatg ctttgatcga catcttcgtc aataatgcct tctacagaag
     7021 tcacacaacg gtcctccatt gccatcatag cagataatac ggctgttgag actccggttg
     7081 ttactttgag tgcgcagctc ggttttgcac cgtcgcaaat cattcccgtc aggttggcaa
     7141 tcatgttttg aacggcaaag gctacctgat tatagtttcc acccatcagc caggtgattc
     7201 cgcaactgga acccgtggca gctactacac agccacacaa ggcagagaga cgtcccaaac
     7261 tttgtttaat atagattaca gtgagatgac tcagcattaa ggcgcgaatc agttcctctt
     7321 cggttttacc attttcttcg gcaaatacga caacgggaag tgtggcggat atgccctgat
     7381 tgccactgcc ggagttactc atgacgggaa tcattgcacc ggccattctg gcgtcgcaag
     7441 cggcggaagt ataagatagt atatgagaga atacgctgtc acccatcact ttatgttcat
     7501 acgttccacg gagcatctta cctaaagaat gcccataatt gcctttaaag gcttgctcgg
     7561 cggctgcttt gttcagacgt gccgtatcga gaataaaacg gatttcatcc agaggggatg
     7621 tcagggcaaa atcatagact ttgcgcagat tcagttccag tgaagcgtct tcttcctctt
     7681 cattggcagt ctgttgcttg tcaagcagta ctttttcatc cgtagctata tagacaaagg
     7741 cagtatgtcc gccggcaatc acagccgtcg ctttttggct gccggctgtg cagattactt
     7801 cgatgtacag tttttccgta atatcttctt tgagagaaat acagattcgc ttctctgcga
     7861 taaacagttt gccttgttct actgcctccg gtgtgcagtc tctcaacact tccaattgat
     7921 attccgatcg gccgatcaac gctcccaagg ctacagctat aggaagtccg accatatctg
     7981 tgccggggat accgactccc attgcattct ttaatatatt ggcactcaat aacacttcaa
     8041 tcttttccgg tttcattcct aatgtttcgg cagctttagc tacacaaagc gctaccgcaa
     8101 tgggttccgt acaccctatc gccggaatca cctctttttt gatcaagtct attatctgtt
     8161 ttctttccga ttcaatcata ccctataagg ctttagtttc cacaaaagta gaaaattctt
     8221 ttttatcaaa catccattag tgaacaaata aaattgcaaa ttgttataaa atcttccaag
     8281 aaccgaactt taacagttag aatagtagaa aaatgaaagc aaaacacggt attctttatt
     8341 tgctgctagc cattttctct tcttcttgca ttcgcgaaga agctcccaat gcagaggcag
     8401 acatactcag ttgcagattg ccgggagtag tcatgacaac gagtccgatt atcactaata
     8461 attccatcaa tatatttgta ggaccgggaa cggacatttc atcccttgca cccgaattta
     8521 cattgactcc gggagccact atcgatcctc ccagtgggac ggctagagat ttccattcgc
     8581 ctcagcaata taccgttacg gctgccgatg gcttttggaa gaagaagtac accgtatccg
     8641 ttattgatac ggaacttgct actatttaca attttgagga tacgctcggc ggacagaaat
     8701 actacatctt cgtagaacgg gaaggagaaa aagtggtgat ggaatgggcc agcggaaacg
     8761 caggttatgc aatgaccgga gttcccaaga cagccgacga ctatccgact tttcagtttg
     8821 caaacggaaa aaccggaaaa tgcctgtcct tagtaacccg cagtaccgga ttcttcggta
     8881 gcattatggg aatgcctatc gcagccggga acctgtttat cggctctttt gatgtaggaa
     8941 atgcaatgag caatccactg aaagcgacca aattcggtct gcctttccgg catataccaa
     9001 cttatctggc aggctattac aagtataaag ccggagatca gtttacagaa ggcggcaaac
     9061 ccgtcagtgg caaacgggat atatgcgata tttatgccat catgtatgag accagtgaat
     9121 ctgtgccgac tcttgacgga acgaatgctt tcaccagtcc caacctggtt tcaatagcac
     9181 gcattgacga cgccaaagag acggacgagt ggacatactt taaacttccc ttccatatgt
     9241 tatccggaaa atacatagat aaagagaagc taacagcagg aaagtataat gtagctatcg
     9301 tattcacttc cagcctggaa ggagatcatt ttaacggagc tatcggaagt acattgttga
     9361 ttgatgaagt cgaactaatc tatcgctcgg aagactgatt ccattcgacc aacgatctga
     9421 tagcagctat ggaaggcaga acagagcaac tataatgaaa taactaatga tttaataata
     9481 atgaaaagat gaaaatccat tcctatatat tcagtttact cgcctgtctg gtaatagccc
     9541 tccccggcta ttcacaggtt gacagaaacg aaacgcttat ccgttccgct cttcacggac
     9601 tggaatatga aatcaaagca gggttcagca tcggcggtac agccccgctc ccgctgcctg
     9661 tcgaaatccg ttcgattgac ggctacaacc caacgctggc tatcagcatc ggaggagaag
     9721 taaccaaatg gtttgccgtt caaaacaagc tcggagtcat tgtagggctg cggctggaga
     9781 ataaagccat gacaacggaa gccaccgtca aaaactataa tatggaaatc ctcggacagg
     9841 gaggagaaag aatcagcggt gtctggacag gaggagtcaa aaccaaagtc cacacttccg
     9901 gactgacaat tcctctaatg gctacttaca agttgagcaa ccgttggaat attaaagccg
     9961 gaccttattt ttcgtatctg ctttcaagag aattttcggg gcacgtatat gaaggatacc
    10021 tgcgtgaagg cgaccccgta ggccccaaag tcgaatttac ggatggtaaa atcgctactt
    10081 atgacttctc ggacgacctg agacattttc agtggggcct gcaaatagga gccggatgga
    10141 gagcattcaa acatctcaat atatatgcag acctcacctg gggattgaat gatatcttca
    10201 gaaatgactt tcagaccatt acttttgcta tgtatccgat ctacttgaat atcggattcg
    10261 gatatgcttt ctagctgacc aaagacggat taatccttac cggattcctc cacctgcttc
    10321 acaccggaga aagcaacttt cacggtctgc ttcaatgcag gtacttttac ctgaatattc
    10381 attgtagcat ttccactttg caccgttcct tctatactgg tggcacaggt acccagagca
    10441 gcggcatccc cctgaaaagt aaggtcttgc tgtccggtga aagtcgaaac gtccgtttcc
    10501 tttttcactg cacacttgtc tatcacgata tcgccgaact ttaatatgtt tccgtttata
    10561 aacagttcaa attccttcag ttccatcttt acttccgtat cactgacctg ggagaaagta
    10621 ataaacttcg gaagtccgtc ggcaatcaca acttcctggt cagagccatc gggcagcatt
    10681 gaaatatcga gatttcccca atacgttccc accacatcgg gagcagtcac cacagcctct
    10741 tcttccggag gagtcgtttc atcattgacc gtattatcat catcactgct acaagccgtc
    10801 aaaagagaga cagagcatat caatgcccac aaatacaata gattcttttt cataattttc
    10861 gggtttagtt attaaataat cgtcatttat aaactaaaaa gaggaaaaaa ggttcaattt
    10921 gcttcctttt ccgaagatat tttgaattca caaccttctt atcaaaaact ttgttatatt
    10981 tgcatagagt aattttaaaa aagccacaac tatgtttaat tcatttggca acatctttcg
    11041 gctcaccagc ttcggcgagt ctcatggaaa aggagttggg ggagtaattg acggatttcc
    11101 tgccggaatc acaatcgacg aagaatttgt acaacaagaa ctaaatcgac gccgtccggg
    11161 acaatccatc ctcaccacac cacgcaagga agcggataaa gtggagtttc tttcaggcat
    11221 cttcgaaggc aaatcaaccg gatgtcctat cggatttatc gtttggaacg agaatcaaca
    11281 ttccaatgac tacaataacc tgaaagaggt ataccgccct tcacacgcgg attacaccta
    11341 caaagtgaag tacggcatcc gtgatcatcg cggcggcgga cgttcttctg cccgcgagac
    11401 tatttcacgc gtagtagccg gcgcattggc taaattagcc cttcgccagt taggaatcag
    11461 catcacagct tatacatcgc aagtcggtgc catcaaattg gaaggcactt attccgacta
    11521 tgatctcgac ctgatcgaaa caaacgatgt acgttgtccg gaccctgaaa aggcgaagga
    11581 aatggcagac cttatatata aggtaaaagg cgaaggcgat accatcggag gtacgctgac
    11641 ctgtgtcatc aaaggatgtc ctatcggatt ggggcaaccc gtgttcggca aactgcacgc
    11701 cgccttgggc aacgccatgc tcagtatcaa tgccgccaaa gccttcgaat atggagaagg
    11761 attcaaggga ctgaagatga aaggctccga gcagaacgac gtattcttca acaacaacgg
    11821 acggattgaa acgcatacca accactccgg aggtattcag ggaggaatca gtaacggaca
    11881 ggatatttac ttccgtgtag tattcaaacc gattgctacc ctgctgatgg agcaggaaac
    11941 ggtgaacatc gacggcgtag atacgacact gaaagcccgc ggacgtcatg acgcctgtgt
    12001 actgccacgt gccgtaccta tcgtagaagc aatggctgcc atgaccatcc ttgattatta
    12061 tctgttggat aagacaacgc agctttaata agtatcaata tgtcaatcta cccatgtgcc
    12121 aatacctgca ctaaaaatct gtcaggctat tggcacatag gctaaataac cgccagtaaa
    12181 ctattcatta tgaacgaaat tcaaaaatat atcgcagcga acgaaccgaa gattatggag
    12241 gacctgttca gcctcatccg tattcccagt atcagcgccc tgccggaaca tcacgacgat
    12301 atgctggctt gcgcccaacg ctgggcacaa ctactgctcg aagccggagt ggaggaagca
    12361 ttggtgatgc cttccaaggg taacccgatt gttttcgcac aaaagatcgt tgacccgaat
    12421 gccaaaacag tattggtcta cgcccactac gacgtaatgc ctgccgaacc gctggaactg
    12481 tggaaaagcc agcccttcga acccgaagta cgggacggat acatctgggc acgcggagcg
    12541 gatgatgaca aaggacaatc ctttatccag gtcaaagcct tcgaatatct cgtcaagaac
    12601 gaactgctga aaaataacgt caagtttatc ttcgaaggag aagaggaaat cggctctccc
    12661 agcctggaag ccttctgcga agagcataaa gagctgttga aagcagacgt tatcctggtt
    12721 tcggatacca gcatgctggg tgccgaactt ccatccctca ccaccggtct gcgcggactg
    12781 gcttactggg aaatagaagt gaccggaccg aaccgtgacc tgcattcggg acacttcgga
    12841 ggtgcggtag ctaatccgat caatgtactt tgcgaaataa tcagcaaagt aacagataaa
    12901 gacggaagaa tcaccgtccc cggattctac gatgacgtag aagaagtgcc acaagcagaa
    12961 cgggaaatga tcgcccatat tccgtttgat gagaagaaat acaaagaagc catcggagtg
    13021 aaagaactct tcggagaaaa gggatacagc acactggaac gcaacagttg ccgcccgtct
    13081 ttcgatgtat gcggcatttg gggaggatat acgggtgaag gctccaagac agtccttcct
    13141 tcgaaagcgt atgcgaaagt ttcctgccga ctggttgcgc atcaggatca tcacaagatt
    13201 tcgcagatgt ttgctgacta tatcttacaa atggcccccg acactgtcca ggtaaaagta
    13261 actccgatgc acggaggaca agggtatgtc tgcccgattt cccttcctgc ctatcaggct
    13321 gcggaaaaag gttttgagat agctttcggc aaaaaaccgc tggcagtgcg tcgcggcgga
    13381 agcattccta tcatttcgac attcgaacag gtattgggaa ccaaaaccgt attaatgggc
    13441 ttcggactcg aatcggatgc aatccattca cccaacgaaa acttctcgct ggacattttc
    13501 cggaaaggaa tagaggcggt ggttgagttc catcaggaat atgcgaaaag ataaaggctg
    13561 cctatagccg cacgcaggac acgaaattaa aagaagaacg gtagacaagc ggataaatcc
    13621 tttgcctacc gttccttttt attcaaaaaa agacatctta ccacataact aacaattaca
    13681 tcaccggagt ttcgaaaagg aaggtaaatg attgactatc cttcaaatcc ttcacggcat
    13741 ctcctgcgta aatttctcct ttggtcaggg acaacttctt caccccagcc ttcggactaa
    13801 aatcaatctt cttcaaatcc agccaaaaca ggttcggagt taaagtagat tcaaagtaat
    13861 acactttatt cttctgatcg gaaacggaac gccagcgagt agaagaaata tgaggcttct
    13921 ccggtgtatt gataccaaac ggaacggaga cattgcgcat cacactcagc acactgggga
    13981 cggctatctt tgcatcggca gtctgcggaa tggcgtgaat gtagaaagag gcacgcacaa
    14041 aacggtcgct cgaacggttc gttcccggca acatctgtaa tccgcccact tctttccagt
    14101 aatcattgac agccaactgc aattcataac gcggagaatt ggtcatcacc tgatattcct
    14161 tcccctcatg gatactcagt ttgccatcca gatattcgat cactgccgtg ttacccgttt
    14221 catcggtaat agccatgtgc aaagtagatt ccggtccccc gttcggcata cggggagcgt
    14281 caatgcggaa agtctctttt ttcatttcat ctaccgcttc acgcaccgtt gcaaaattgt
    14341 caagtacata ttgagtccag atactgattc ccattgccgg acgggtatct ccgggaagtg
    14401 aataaacaga ttccggcagg aaaagcaggc ttgccaccag ccctttttca ttcattccgt
    14461 cacaagtacc tatatcatag cctgttgcga ttacgcttcc atatttggaa gtccagttta
    14521 ctgttttttc tttattgtgt cccgcacgct gcattccacg tggaaacaca tagatattcg
    14581 acatgatgtc ttctttccag tccatcgtgc gaccagtgac caccattccg tccggtccca
    14641 gatatacggc acgcgtacat gcttccgccg gctgtatgcc catcaaagag acggcagcta
    14701 acaccaatgc aacacccgta agttttttct tcatattcct tccaaattaa atagttgata
    14761 ctcttatatc tataataaca aatatacaac gaatattgcc tgagagagag aagaatttaa
    14821 gggaaaaaag ggaatttatt cagaaaaaat cttatccgct cttatttgag ttaaaaaagc
    14881 ctgcggatgg aaggaaacat tacacattat ttgcttttca aatgggattt cattattttt
    14941 gtacataacc tatcataaaa actaaggagg gcaaatgcgt atgagacaaa aagttagcat
    15001 atcacagctt ccaattcgtt tgggaatctt tcttttgctg tattttgttc cgcaatcact
    15061 ctctgcgcaa gaaaacaacg acagtacgca catacttcgt aacggtgcat ccataacgcc
    15121 ggacgacgta ctaaaacagg ccaacattaa cttgtttcca gaaaagagca ctacatattc
    15181 tttatattca cccggacagt tggagcatat accccgcttt tcactcaaaa gggatatttc
    15241 cctaccttat cagaccaatc cttccctact cttccgaggt gattacagta cgggcggggt
    15301 attgcatcaa ttcgatcgtg gagcactgtt cggttccgga agtcagacaa gtatggcagg
    15361 catcgggcgt ttcaacagtg cttcactagg ttatcagcat attttcaatg agcaattcga
    15421 gttacaagtc cgtgccaatg cgctgaaggt caacatgtcc cacatcaccg gacaggcttt
    15481 cagcacttcg ggcgccttcc tttaccatcc ttccgaccgt gtcaccttga aagtcttcgg
    15541 atcatacgac atcagaaact cttacggaat gagcacccat agctacggag ctacgatgtc
    15601 cgtcgatatg tccgaccgct tcgggatgga aatgggagta cggcgatact atgatgcgat
    15661 gagcggacgt tgggaaacgg ttcccgttat gattccttac taccattt
//
