LOCUS       gnlProkkaEAIKPGOG_65   15717 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EAIKPGOG_65.
ACCESSION   gnlProkkaEAIKPGOG_65
VERSION     gnlProkkaEAIKPGOG_65
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:35:55
            Original ID  :: gnl|Prokka|EAIKPGOG_65
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 30800
            Orig. end    :: 46517
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15717
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15717
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15717
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2233..3201
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_20"
                     /sec_met_domain="PF04055 (E-value: 3e-18, bitscore: 57.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGFAAKQIASWLYEKKVASIDDMTNLSLKHRELLKQNYEVGAEA
                     PVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGCKMNCKFCMTGKQGY
                     TANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALELLTATYGYAWSPKR
                     ITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAFSITEMVELLKNYDF
                     SKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAIPGVDLEGADMDTMT
                     RFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             3220..4260
                     /locus_tag="ctg65_21"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4265..5359
                     /locus_tag="ctg65_22"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5369..6610
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg65_23"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6597..7124
                     /locus_tag="ctg65_24"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7130..7903
                     /locus_tag="ctg65_25"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETIKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7910..8308
                     /locus_tag="ctg65_26"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVIMSIATAYVVPHSSAVKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTDATAPAESAPATETPAPAETPAPAAE"
     CDS             8558..9955
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.2; E-value: 4.5e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg65_27"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSKVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGALLFGFKMQVALAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDEAGAFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAQGLEPEEPFRMKDIVYIVTNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMTIGAVMLIFVHTMFAL
                     PILNVWWFATIIMIVLGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAVFGVLALIVSLMLKAENRKKGYGLEEA
                     NIKKESV"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_28"
                     /sec_met_domain="PqqD_RRE (E-value: 3.8e-10, bitscore:
                     30.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.5e-17, bitscore: 54.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLDVIPCRSEHITVEREGETIVLSFPRFKYTWMQRFL
                     VPKGMSKELHVHLEEHGTVVWELIDGKRTVREIIEKLADHFQNEAGYESRVSTYLYQLQ
                     KDGFIKFHFPTE"
     CDS             complement(10424..10708)
                     /locus_tag="ctg65_29"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLSEGREASRLRRERNNEKLKHLNRSNEHYPLP
                     NTTSEEMERIIRDSEKKKERDNSYFVWGTLIIMGVLIASAVILWAIFIK"
     CDS             complement(10732..11796)
                     /locus_tag="ctg65_30"
                     /transl_table=11
                     /translation="MKKLIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVSYIPGEFSKYADRYLRLTNVSAEPDEYWELNSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKSINVPYSKSNETKKAAPVIPATVKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNTPSDGAQLKIMLDNLNAQEDAMTKMFSGTRDK
                     EEKTFTIRLTPDKELNNEVAFRFSKKLGVVANNDLAGTPFYITLKDLKTVKIPQDDGKK
                     KKEPEGIAYNVPGQAQITLTDGKKKLYEGEVPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     NTGGLLKVDREEGK"
     CDS             complement(11870..13381)
                     /locus_tag="ctg65_31"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYIIEHEPIASIDLMERAATALTKAIMNRWSR
                     ETPVTVFAGPGNNGGDALAVARMLSEKGYKTEVYLFNPKGELSPDCQTNKELVEMAEEV
                     TFHEISTQFVPPTLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKNNIIRADVTFSLQLPKLAFLFAENTEYVGEWDLLNIGLSEEGIEETET
                     NYEMLELEDIRSLIKLRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPICNNDILQTSVPEAMVETDANETCFAIPTDTDDYQAVGIGPGLGRSEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLTKAC
                     ELAHAANVHIILKGAYSAIITPAGKCYFNPTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDFAQKKQGMIGLIASDIITCLPTAWRLVSE"
     CDS             13884..14105
                     /locus_tag="ctg65_32"
                     /transl_table=11
                     /translation="MEKTRIGLNAGKVWRILNEKGELSMFDLCRELGLTFEDVALAIGW
                     LARESKVFLRKREGMLFASIENVEFTFG"
     CDS             14444..14980
                     /locus_tag="ctg65_33"
                     /transl_table=11
                     /translation="MDSIQIKDKQFTVSIKEQDIQKEVIRVANEINRDLADKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGVTSTGVIKEVIGLNEDIAGRTVVIVEDI
                     VDTGLTMQRLLETLGTRNPESIHIASLLVKPEKLKVDLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             15014..15583
                     /locus_tag="ctg65_34"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLEVPEDELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAIDKL"
ORIGIN
        1 cgtcatccac tgcctacctg ccctttgttc agaatggcta tgctcatttc cagttgaatg
       61 gcttttcaca ggcggatgcc aagtcgttct caaagcaata tttgtctact tactccaagg
      121 ctttgtctgc acagcaggaa gatattcttg cttcgtgggt gctggctaaa caaccgcgct
      181 gtttgagtgt attgctcaac gagctggttt cgttcggtca gtacgatgct ctcaatgaat
      241 atatgcgtgg atattgccgg ctcaatgagg ttgggcaatt ctatgacagt gtgctacggc
      301 gtttgtcggc tgattatggt tccgaagaga ttggaagaac gcttctgatg ctttcactta
      361 ctttagaagg atttaccgaa gatgaagtga agagcatggc agacattaat cagatacttt
      421 ggtcgcagtt gagagtggaa atgagcagct ggctcaccaa caaaggagga cgatattgca
      481 ttggtgacac acaaatggta gaggcgatcg aacgctattt cgctcaagat gacgaatgta
      541 tagatgatag tcgccatgaa attatttccg ctctgctgga tgaggaagag atcctttccc
      601 atccgttgac ttttgccgat tataactatc gcatgaaaca gttctgctac catgattcgt
      661 atcgctataa agtggagatt acctatcaat gctataagat gcaagaatgg gatatattga
      721 aggattggat ttgtgatgtg gagattttcg agattctgta tcgcacgaat cgttctctgt
      781 tggaagatag ctggaaggcg atcatgaacg acaatcctga agttacgcct gaagtctatg
      841 ccgaattgga ctttgatgag atcgattctt ttttaattcc tgtcattgct aatgatatgg
      901 ctactttctt gagcagttct ttccatctga cgaaggcggc agctgctgtg agtgagaaga
      961 gtatggaagg tgctgccatg ccactcattg ccaagtcggt attgaagatg aatgagggat
     1021 gtcggtatgc ccgtaatgaa gaatacgaaa cggcatgcga ctgtttcctg aaagcattgg
     1081 tgatgcagga gaacatagta ccgactccgg aactggagat tgccaacacc tgtcgaaatc
     1141 tagctttggc atattactac aatgagcaat acaatgaagc ggcgatctat ttgaataggg
     1201 cgcttgatta tcatgcggct tctgctgacg agaagagtca ggcagaagtc attgaacttt
     1261 ccgaatatct ggcttattgt gattactata aggatgagga agagagtgct gccgagaaat
     1321 tccggaaagt agctgaaatg cacgagtcgt tgaatggcag actgtccggt ggagtggcta
     1381 aatgtttgcg tatgcagggt aaatgtcttt attatatcaa acgatacgat gaagcatgga
     1441 tgctgatgaa tcaggcgttg gacattgcta tacagataga taataaaaaa cagatcgtcg
     1501 cttgtcataa acagttgtat tatctgtgca gggaattcaa acggatgatg aatgaacgtg
     1561 gcgatgagca ggcgtctact ttattcttcc gtgagtctct tctgcatgaa atgtatttca
     1621 gcgaaaaacc gcgtctggcg gaactgactg tccgatatga ggcattgaga tgtgatatta
     1681 tgcagcagta ttacatgaat aaagactatg ataacgtgat tcgtattgcg acgtctttgg
     1741 atattcacga tgatgctgac cctaatgctt cctgtctggt atattattac aaagcacagg
     1801 cttatgtgaa gttggagaat tatccaatgg cgaaagaggc tttcttcaga gagttcgaac
     1861 tgcgaaagaa gtatttggga tgggaggaag aagatacgat tctggcttgt cagaacttag
     1921 gggttttgta cagcttttgt aatgaacggg aagaggcgct ggcttgtttc cgtgaggcgt
     1981 acggtcatga agtgaaaaag aatggcgagg attctgaaat ggcgcaaaag ctacttcaat
     2041 atatcagcgt ggttgaatca taacggaggc atacttccct tttttgttaa cttttacatt
     2101 cctgctatac ggaaatcgac tttatttcct tacatttgca gatataaact atcaacagaa
     2161 agaagaatgt ctaaatatcc ccttttagga atgactcttg tagagcttca atcattgaca
     2221 aaaagactgg gtatgcccgg ctttgctgcc aagcagattg catcctggct ttacgaaaag
     2281 aaggtagcct cgattgatga tatgactaat ttgtcattga aacaccggga gttgctcaag
     2341 cagaactatg aggtgggagc agaagctccg gtagatgaaa tgcgctctgt agatggtacg
     2401 gtgaagtatc tttataaagt gggtgagaac cattttgtag agtcggttta tataccggat
     2461 gatgaccggg caacgttgtg cgtgtcgtca caagtaggtt gcaagatgaa ttgtaagttc
     2521 tgtatgaccg gtaaacaggg gtataccgct aacctgaccg ccagccagat catgaatcag
     2581 attcattcgc tgccggaacg ggacaaactg actaatgtcg taatgatggg aatgggcgaa
     2641 ccgctcgata acctggatga ggtattgaag gcattggaac tactgaccgc tacctacggt
     2701 tacgcatgga gtccgaagcg tatcacgctt tctactgtcg ggctacggaa aggattgcag
     2761 cgttttattg aagaaaacga ctgccacctt gccatcagcc ttcactctcc gctgaccgtt
     2821 cagcgtgctg aattaatgcc ggcggaaaag gcgttttcaa tcaccgaaat ggtggaactg
     2881 ttaaaaaact atgattttag taaacaacgt cgactttcgt ttgaatatat tgtttttaaa
     2941 gggctcaatg attcgcaggt ctatgccaaa gagttgctga aacttcttcg cgggctggat
     3001 tgcagggtga atctgattcg ttttcatgcc ataccggggg tagacctcga gggggcggat
     3061 atggatacga tgacccgttt tcgtgattat ctgacatcac acggactttt caccactatc
     3121 cgttcatcca ggggcgaaga tatttttgcc gcttgcggta tgctgtcgac agcgaaacag
     3181 gagaaaaata atgaaagtta atatataaaa ccgaacatca tgaaaaagta ttcttttatt
     3241 ttatgcatcg ctttggtagc ctttgtcgtt gcatcttgtg gtctgaaagg aaatcacacc
     3301 tctagtggtc gtgcttacga gcttttggtt gtagtagatc acggtgtttg ggatcgtgct
     3361 gccggaaggg ctttacatga tgcgctcgat gctgatatgc ccggtttgcc gcagtcggaa
     3421 ccttctttcc ggattatgta tacttcgccg aaagattatg attctacgct gaagttgata
     3481 cgtaacatta ttattgtaga tatacaggat atatatacga aagcctcgtt caaatatgcg
     3541 aaggacgtat atgccaatcc gcagatgata ttgactatcc aggctccgaa cgaagaagag
     3601 ttcgagaagt ttgtggaaga gaacaaaaag acgattgtcg acttctttac ccgtgcggaa
     3661 atgaaccgtc agattacgtt cctggaaggg aaacacagta atttcatttc gcagaaagtg
     3721 gacagtttgt tcggatgcga catctgggtg gatgccgaac tggctaattc aaagaccggg
     3781 gatgatttct tctgggcttc taccaacaca ggtactgccg accgtaactt tgtgatgtac
     3841 tcttatccgt acactgacaa ggatacgttt accaaagaat attttgtgca caaacgtgac
     3901 tccgtgatga aagccaatat ccccggattc aaggaaggcg tttatatgtc gaccgatagt
     3961 ttgctgaccg atgtccgtcc gatcaatgta cagaacagct acacaatgga agcacgtggc
     4021 ctgtggcgta tgaagggcga ctttatgggt ggtccgtatg tgtctcatac tcgtctggac
     4081 gagaaaaacc aacgaattat tacagcagaa atatttgttt attcacctga taaaatgaaa
     4141 cgcaacctgg tacgccagat ggaagcatct ctgtatacac tgaaacttcc gaatgaagtt
     4201 cagcagaagc agattccatt gggagaagca tctaaggaag cggaacaaac taataaataa
     4261 aaacatggaa gataacaaga taaggatagg tatcacccaa ggagatatta acggggtggg
     4321 ctatgaggtg attcttaaga cattttccga ccctacgatg ttggaactat gtactccgat
     4381 tatttatggc tcaccgaaag tagcggctta tcatcgcaaa gcgctggata tacagaccaa
     4441 tttcagcatt gtcaactctg ctaccgaagc ggggtacaac cgtttgagcg tggtgaactg
     4501 tacggatgat gaggtgaaag tggaattttc caaacccgat cccgaagccg gtaaagctgc
     4561 gctgggggct ttggaacgtg ccatcgaaga atatcgcgaa gggttgatag atgttatcgt
     4621 aacagctccg atcaacaaac atacgattca gtcggaagag ttctccttcc ccggacatac
     4681 ggaatatatc gaagaacgtc tgggcaatgg tgataagtca ttgatgattt tgatgaagaa
     4741 tgacttccgg gtggctttgg tgacgacaca tatccctgtc agagagatcg cgactacgat
     4801 taccaaagaa ctgattcagg agaaactgat gatattccat cgttgtctga aacaggattt
     4861 cggtatcggc gctccgcgta ttgcggtgct ctctctcaat cctcatgccg gagacggtgg
     4921 tttgttggga atggaagagc aggaagtgat tatccctgcc atgaaagaaa tggaagagaa
     4981 aggaatcctt tgctacggtc cttatgcggc cgacggcttt atgggttcgg gcaattatac
     5041 tcattttgac ggtatcctgg cgatgtatca cgatcagggg ctggctccgt tcaaggcctt
     5101 ggctatggaa gacggggtga actatacggc aggcctgccg gtagtacgta cttctccggc
     5161 tcatggaacg gcatacgata ttgcaggcaa gggattggct tgtgaagatt ctttccgtca
     5221 ggcaatctat gttgccatcg atgtgttccg taatcgtcag cgggaaaaag tggctcgtgc
     5281 caatccgttg cgtaaacagt attacgagaa acgtgacgat agtgataaac tgaagctgga
     5341 tacagtagac gaagattaaa aacgagtgat gacgagagca gagatacaac aagtgaaaca
     5401 gcgtttcggt attattggaa atactgaagc attgtcgcgc gccatagatg ttgccattca
     5461 ggtagctcct accgatttgt ctgtgctgat taccggagaa agtggagtcg gaaaagaaag
     5521 ttttccgcag attattcatc aatatagccg gaggaagcac ggacagtata ttgctgtcaa
     5581 ctgtggtgct attccggagg gcacgattga ttccgaactg ttcgggcatg agaagggtgc
     5641 gtttaccggt gcgattggcg aacggaaagg gtactttggc gaagccgacg gcggtactat
     5701 ttttcttgat gaagtagggg agttgccgat gtctacccag gcacgtttgc tccgtgtact
     5761 ggagagtggt gagtttatga aagtaggttc gtccaaagta caaaaaacgg atgtgcgtgt
     5821 ggtggcagct accaacgtca atctgacaca agcgattgca gaaggacgtt tccgtgaaga
     5881 tttatattac cggttgaata cggtgcctat ccagataccg cctttgcgtg aacgtggtga
     5941 cgatgtactc ttgttgttcc gtaagttttc cgcagacttt gcagagaaat accggatgcc
     6001 tgctatccag ttgacggagg atgcgaagaa agagttattg gcttacccgt ggcccggcaa
     6061 cgttcgtcag ttgaagaaca tcaccgagca aatatctatc attgaaacca acagggagat
     6121 ctctgctgct atcttgcaga attatcttcc tgcacaaaat acgcaacgtc ttcccgcgct
     6181 gatgggaacg cgtgagagta aaggctttga gagcgaacgg gagattcttt attctgttct
     6241 gttcgatatg cgccaggaag tggcggagct gaagaagatg gtgcacaacc tgatggcgga
     6301 acgtgccgga caggtggggc aggtagggca aatgggaacg gtggttacta ctccggtagt
     6361 gacggcgcat caaccttcgg tacctgctat cattcacacc atgcagccta cggtttgcaa
     6421 ggatgacgat gacatacaag acacggaaga atatgtagaa gaatctcctt tgtcactgga
     6481 cgaagtggag aaagaaatga tacgcaaggc acttgagagg catcatggaa agcggaagag
     6541 tgcggccaag gacttgaata tttccgagcg tacactttat agaaaaataa aagaatatga
     6601 attggattaa gaaaataata cgccctttgc tactgttcgg cttgccgttg gtagtcattg
     6661 cgtgcactgt ttcctataag tttaacggat cgtctatcaa ttatgataag gtaaagacca
     6721 tttcgatagc cgacttcccg atcaagtcgg agtatgtata tgctccgttg gcaaccaaat
     6781 tcaatgagga cctgaaagat atcttcatcc ggcagacccg tctgcaactg ctcaagccga
     6841 gtcaaaatgc cgacttgcag attgacggag aaatcacagg gtacaatcag tacaaccagg
     6901 cagtatctgc cgacggttat tcttcggaga cgaagttgac tatcaccgtc aatgtgcgtt
     6961 ttgtcaacaa caccaatcat gccgaagact ttgaacaaca gttttctgcg ttccgtacct
     7021 acgactctac ccagttgttg actgccgtac aggacggatt gattgctgaa atgtctaaag
     7081 agatcaccga ccaaattttt aatgcaactg tagcaaactg gtaatataaa tgacttctgt
     7141 taactttcaa caatggattc agcatcccga gacgctgaat agggatactt tgtacgaact
     7201 gcgcaatctt cttgcgaggt atccgtattt tcagtcactt cgtctgttgt atctgaagaa
     7261 tctgtatatt ctccatgata ttagtttcgg tggagaactg cggaaagcag ttctttacat
     7321 tgcagacaga cggcagttgt tccggttgat tgaaggtgac cgctatgatg tgcaggcacg
     7381 gaaaaaggga gtacctctca cggaggtgct gaaagacgaa ccgtccgtag accgcacatt
     7441 agcattgatc gacgctttct tgtccacagt acccgaagag gtgactgccc ggaccagttt
     7501 cgactattcg atggattaca cctctttcct tttggaggag actccggcca cggaacagcc
     7561 ggctgaagaa acgcccaaac tcaaaggctt cgaactgatt gacgatttta tagaaaagag
     7621 cgagagcgac tctcccctct gcatgaaacc tttaagagaa gaaatgccat cttcgccaac
     7681 ctcttcggac gaacttaccg aagaagaaac gataaaggaa gaagaggaag atgacagctg
     7741 ttttacggaa actttggcaa aaatctatgt taaacagcaa cgatattcaa aagctcttga
     7801 aataattaaa aaattaagct tgaaatatcc aaaaaaaaat gcttactttg cagaccaaat
     7861 cagatttttg gagaaattga ttattaacgc taattcaaaa taactaaaaa tgtacttatt
     7921 attcgttatc ttaatggtta ttgcagccct gttgatgtgc tttatcgtgc tgattcagaa
     7981 ctcaaaagga ggcggacttg cttccggatt ctcttcatcc aacgctatta tgggcgtacg
     8041 caaaactacc gattttctgg aaaaagcaac ttggggctta gctatcttca tggttatcat
     8101 gagtattgct accgcttatg tcgttcctca ttcttctgct gttaaagatg cagtgttgga
     8161 acaggctcag aaagaacaac agactaaccc gtataacttg cctgctggta ctgctgcacc
     8221 gcaaacagat gctactgctc cggcagagtc tgcacctgca acagaaactc cggcaccggc
     8281 tgaaactccg gctcctgctg ctgaataatc cattcggatt gcagagaggg attgggtgaa
     8341 accatttaag agggggcaga aggttttctg tatttctcta tatttgggcg cagattacac
     8401 ggattacacg gatttgttaa tgaatccgtg caattcatgt aatccgcgcc taactttttt
     8461 tctaaaaaca aatctctttg tgaggtatac aatggagatt taactatctt tgttggtcgt
     8521 aaaaaataaa attattaact actatttaaa tataacaatg acagaacaat taaaacagaa
     8581 attgaatgac tccaaggtgt tgcgttggag cgttctagca ttggtcgctt ttaccatgtt
     8641 atgcggctac ttcctcacgg acgttatgtc cccgctgaaa cctatgcttg agaaagaact
     8701 actctgggat agtttggatt acggattctt taccagcgct tacgggtggt tcaatgtatt
     8761 cttgctgatg ttgattttcg gcggtattat tctggataaa atgggagtac gctttactgg
     8821 aatgggcgcc tgtctgttaa tggtgttcgg ttgtggactg aaatattatg ctatctctac
     8881 cactttcccg gaaggtgccc tgcttttcgg attcaagatg caggtagcat tggcagcatt
     8941 gggatatgct atctttggtg ttggtgtgga aattgccggt attaccgtct ctaagattat
     9001 tgtgaaatgg tttaaaggca aggaaatggc gttggctatg ggacttgaaa tggcaacggc
     9061 acgtatcggt acaactctgg caatggtgct gactgtacct ttggctgact tcttcggatc
     9121 tactgacgag gcaggtgctt ttcataccaa tatccctgcg ccgattcttt tctgcctggt
     9181 tatgctttgt gtaggtacga ttgctttctt tatttacaca ttctatgata agaagttgga
     9241 tgcttcactt gacgcacaag ggcttgaacc cgaagaacct ttccgtatga aagatatcgt
     9301 atatatcgtt actaacaagg ggttctggct gattgcattg ctgtgcgtat tattctattc
     9361 ggctgtattc ccgtttatca agtatgcggc ggacttaatg gtacagaaat ataatgtaga
     9421 cccgaaattg gcggggacga ttccgggatt gttaccgatc ggtgcgatca tcctgactcc
     9481 gttgttcggt tctctgtatg accgtatcgg caaaggtgca acgttgatga ctattggtgc
     9541 agtgatgctg atattcgtgc atactatgtt tgcacttcct atcctgaatg tgtggtggtt
     9601 tgccacgatc attatgattg tgttaggctt cgctttctca ttggttcctt cagctatgtg
     9661 gccttccgtt ccgaagatta ttcctgagaa acagttgggt acggcttatg cattgatttt
     9721 ctgggtacag aactggggat tgatgggggt gcctttgctg atcggttggg tgctgaactc
     9781 ttattgcaag gggccggtgg tagacggtgc acagacgtat gattacacgt tacctatggc
     9841 tatttttgct gtcttcggtg tacttgcgtt gattgtatct ttgatgttga aggcagagaa
     9901 caggaaaaaa ggttatgggc tggaagaagc taatattaaa aaagaatcgg tataatatta
     9961 aagactcagt ataatattct tgaaataagg agatcaaagt atggcagcga aagagaaaat
    10021 caatctgttg gatgtaattc cctgtcgcag tgaacatatt accgttgaaa gggaagggga
    10081 gacgattgtg ctctccttcc ctcgttttaa atatacgtgg atgcaacgct ttcttgttcc
    10141 gaaggggatg tcgaaggagc ttcatgtgca tttggaagaa cacggaacgg ttgtatggga
    10201 actgattgac gggaaacgga cggtgcgtga aatcatagaa aaactcgcag accattttca
    10261 gaatgaagca ggctacgagt cacgtgtatc tacttatctt tatcagttac agaaagacgg
    10321 ttttataaaa tttcatttcc ccacagagta acacagtgtc tctcactgaa tcctctcttt
    10381 acggtaagat taaaaggctc tgtgttactc tgcggggaat aaattattta ataaagatag
    10441 cccatagtat aacggcactt gcaatcagga cgcccatgat aatcagtgtc ccccatacga
    10501 agtagctgtt gtcccgttcc tttttcttct cggaatcacg gatgatacgt tccatttctt
    10561 ccgacgtggt attgggcaac gggtaatgtt cgttgctacg gtttaaatgt tttagcttct
    10621 cgttgtttcg ctcgcgacgc aggcgggagg cttctcttcc ttcgctaagc cgacgtatca
    10681 tgtcgagcat gtgtccttca ccgcccatat tcttttcttt ttagagtttc attatttccc
    10741 ttcttcccgg tctactttaa gaagtccgcc ggtattcggg tcgaaataca ccttgatagt
    10801 tgagttcttg ttgaacaata ccggagccaa gtattcgata atgccgaatt gcgttacagg
    10861 tacttctcct tcatacagtt tctttttgcc gtcggtcagc gtgatttgcg cttgtccggg
    10921 gacgttgtag gcaattcctt ccggttcttt tttcttcttc ccatcgtctt gtggtatttt
    10981 gactgttttc aagtctttca gagtgatata gaaaggagtg ccggccaggt cgttgttggc
    11041 aactaccccc agctttttag agaaacggaa agcaacttcg ttattcagtt ccttatccgg
    11101 tgtaagtcgg atcgtaaatg tcttttcctc tttgtcacgt gtgcccgaga acatcttggt
    11161 catggcgtct tcctgtgcgt tcagattgtc gagcatgatt ttgagttggg cgccgtccga
    11221 aggagtgttg tccgcttggc cgcgtaaaag ggcatttttg ctttcgcgga tattatagat
    11281 ctctttggct accagttcgg ccattttggc ggtggagctg gccattagga tttcttcggt
    11341 aaggaaatca cgaggattcg cttttacggt ggcgggaatg acgggagcag cttttttagt
    11401 ctcgttactc ttgctgtaag ggacgttgat tgatttcaca attccgtcct cagtcagttc
    11461 catgagaggg gctactgttt tatcctttag tttgacaaag taagtcgttt cgctgttagg
    11521 gactcctact gatttaactt ttacgctgtt cagttcccaa tattcgtcgg gctcggcaga
    11581 tacgttggtc agtcgcagat aacgatctgc gtatttactg aattcacccg gtatatagct
    11641 gactttgttg gcttttattt cgagttctat ctgtgttttg ggaaggctgt acaccactcc
    11701 gtagtctttt cctcgggtaa cgcctgtcaa cacttctgtt tgtgcatagg cggaagtagc
    11761 cattagtagt cccgttgcta taatcaactt tttcatattc ggttcttttt taactggttt
    11821 tgaaaacaaa gttaatgaag ttattgaaaa aactgtaagt tcttaacttt tattcgctta
    11881 caagtcgcca tgccgtgggc agacaggtga tgatgtcgct ggcaatcagt ccgatcatcc
    11941 cctgcttttt ctgggcgaaa tctccggcca gtccgtggat gtaagtaccg attttagctg
    12001 catcctcggc gggatagcct tgggctagca gagctaggat cactccggtc aatacatcgc
    12061 cactgcctcc ggttgccatt cccggatttc cggtcgggtt gaaataacat tttcctgccg
    12121 gggtgataat ggcggaatag gcgcctttca ggatgatatg tacgttggcg gcatgagcca
    12181 gttcgcaggc tttggtcagt cgttcgtatg aatcctgaca cttgccggtc agccgttcca
    12241 gttccttcgg gtgtggggtg aggatagaac ctttcggcag gtgtgtcagt gtgtggcggt
    12301 ggttggcaag gatgttgagt gcgtcagcgt ccactactac gggagtctgg caatgttcga
    12361 gctgttcgag cagggcagct tccgtttcct cgcttcttcc cagtccgggg ccgatgccga
    12421 cggcttggta atcgtccgtg tcggtaggta tggcaaagca ggtttcattg gcatcggttt
    12481 ctaccatagc ttcggggacg gaggtttgaa gaatgtcgtt gttgcatatc ggtgcgtgta
    12541 cagtcagcag tcctactccc gaacggagac aggcacgagc tgccaatacc gatgcacccg
    12601 ccataccttt cgagccggca atcaggaggg catgaccgaa attccctttg tgggcaaact
    12661 gttggcgtag tttgatgagt gaacgtatat cttccagttc cagcatctcg tagtttgttt
    12721 ccgtctcttc aataccctct tcgctcaatc cgatattcaa taaatcccat tcgcctacat
    12781 attcggtgtt ttcggcaaaa aggaaagcga gtttcggaag ctgcaggctg aacgttacgt
    12841 cggcgcggat aatgttgttt ttcacgttga atgtattttc ttctcccata agtccggaag
    12901 ggatgtcaat ggctactacc atagccggag aagaattgat atatttcaca acggctgcga
    12961 atcctccgct caacggtttg ttcagtcccg aaccgaaaag cccgtcgata accaagtggt
    13021 ccggtgtcag ggtgggaggg acgaattggg tgctgatttc gtggaatgtc acttcctctg
    13081 ccatttccac cagttccttg ttggtctggc agtctgggga gagttcacct ttcgggttaa
    13141 agagatatac ctctgtttta tatccttttt cggatagcat acgagccacg gcgagggcgt
    13201 ctccaccgtt gttgcccggt ccggcaaata cggtgacggg agtttcccgg ctccacctgt
    13261 tcattatggc ttttgtcagt gcggttgcgg cacgttccat gaggtctatt gaggcaatcg
    13321 gctcgtgctc aatgatatat gcgtccagtt tctttatact gctgcttgga aatattttca
    13381 ttgtgatgtt cttttaagtt ttcgccctac aaatgtacat gattattctg acttttcccg
    13441 tttgttatgg gaagaaaaac gtgtcaatca tagatagatg agttacagga gataggtcgg
    13501 aaaattcttc tttatggaaa gtaaagttgt tttgtatagg tagcaaagtt cctgttgaca
    13561 ggcgaagaac tataaacgca agctttgatt atagattgta atgcatgaag tgaaactttt
    13621 cagcaagttt acatttaatg gggagtaact tctctatgaa tgtaccggac ataagatata
    13681 gcctgttcgc acaaggatga cgaagaagcg cttcagtcag tatcggagat agtaggagaa
    13741 ttgagtatta tggtgctgat tatttgcttt tttcgagaag aatgttatct ttgtaggtag
    13801 gtaatgtgca taacattatt ttcctgtgct cacaatgatt aaatcataga taacggattg
    13861 tttaatcttc taaagtttgc attatggaaa agactagaat tggtttgaat gccggaaaag
    13921 tatggcgtat cttaaatgaa aaaggtgaac tgtcaatgtt cgatttgtgc cgtgagttag
    13981 gtttgacgtt tgaagacgta gctcttgcta tcggctggtt ggcaagggaa agcaaggtct
    14041 ttctgaggaa aagggaagga atgctttttg ccagcattga gaatgttgaa tttacttttg
    14101 gctaaggtgg aaaccaatgt acatttaagg tgggaatccg ctttattatc tacccgacta
    14161 aaaatttaat gaagtggatc agtgggggtg tttgcgtcta aaatatgatt actcttattt
    14221 ctttccggct attcttttta ttgtctattt attcttatcc gataggctgt taaatagctt
    14281 ttttatttat ttcataaagg gatattctgt ggactgctta gtggaggaac atcgctaact
    14341 atctcaccga ttctgcttct tctttcaaag aaattgcaga agaagatgta cagagtggaa
    14401 taaaaattgt atttttgcga caactttttt aaaataaccg gttatggata gcattcagat
    14461 aaaagacaag cagttcactg tttccattaa agaacaagat attcagaaag aagtgattcg
    14521 cgtggcgaac gaaatcaatc gcgatttggc agataagaac ccactattcc tcagcgtgtt
    14581 gaatggttcg tttatgttta cggccgactt gctgaaacac atcacaatcc cttgcgaaat
    14641 atcgtttgtc aagctggctt cttatcaggg agtgacttcc accggagtta tcaaagaagt
    14701 aatcggactg aacgaggaca ttgccggacg tacggttgtt atcgtagaag atattgtaga
    14761 cacggggctg actatgcagc gactgctcga aacattgggt acgcgtaatc ccgaatctat
    14821 ccacatcgct tcattattgg tgaaaccgga aaaactgaag gtggacctga acattgaata
    14881 tgtagcaatg gaaattccga acgactttat cgtgggatat ggattggatt atgacggttt
    14941 cgggcgaaat taccccgaca tttacacggt agtagactaa attcaaatac aaattaattt
    15001 ttaggtaaaa aagatgttga acattgtaat tttcggtgct ccgggttctg gaaaagggac
    15061 acagagcgag cgtattgtag aaaagtatgg tatcaatcac atctcaacag gagatgtatt
    15121 gcgtgcagaa atcaagaacg gtacagaact gggtaaaact gctaaaggtt atatcgacca
    15181 gggacagttg attccggatg aactgatgat tgatattctg gcaagcgtat tcgatagctt
    15241 caaagatagc aaaggtgtaa ttttcgacgg tttccccaga acaatagcac aggcggaagc
    15301 attaaagaag atgttggccg agagaggaca ggatgtttct gtaatggttg accttgaggt
    15361 gccggaagat gaacttatgg tacgtctgat taagcgtggc aaagactccg gccgtgctga
    15421 cgataacgaa gaaactatca aaaaacgtct gcatgtatat cattcacaga ctgctccgct
    15481 gattgactgg tacaagaacg aaaagaaata ccagcatatc aacggtctgg gtactatgga
    15541 aggtatcttc gctgaaattt gcgaagcaat agacaagtta taataatatt attagaaaag
    15601 tatggctgaa tcgaattttg ttgattacgt aaagatttac tgccgctcgg gtaagggcgg
    15661 aagaggctct acgcacatga ggcgcgagaa atattgtccc aacggaggtc ccgacgg
//
