LOCUS       gnlProkkaPAFCBPAC_222  11375 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PAFCBPAC_222.
ACCESSION   gnlProkkaPAFCBPAC_222
VERSION     gnlProkkaPAFCBPAC_222
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:43:01
            Original ID  :: gnl|Prokka|PAFCBPAC_222
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11375
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..729
                     /locus_tag="ctg222_1"
                     /transl_table=11
                     /translation="MLTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEIL
                     MASSTAKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMF
                     SGVRNKEEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIP
                     QEDGKKKKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTI
                     KVYFDPVTGGLLKVDREESK"
     protocluster    1..11375
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1027:1375]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1028..1375
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..11375
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11375
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             751..1038
                     /locus_tag="ctg222_2"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(1028..1375)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg222_3"
                     /sec_met_domain="PF05402 (E-value: 1.4e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 5e-10, bitscore: 29.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(1420..2808)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 91.3; E-value: 8.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg222_4"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(3099..3494)
                     /locus_tag="ctg222_5"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEAPATETPAPAAE"
     CDS             complement(3501..4295)
                     /locus_tag="ctg222_6"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNQLARYPYFQSLRLLYLKNL
                     YILHDINFGAELRKAVLYIADRRKLFHLIEGERFAVESQKKGLPLSEVLKDEPTVDRTL
                     ALIDAFLSTAPEEVTSQTSFDYSMDYTAYLLEETPVVDEPAEAMPKLKGHELIDNFIEK
                     SETDPVVYLKPLKEEEKAKAASSAETNETGRTDETTETNTVEEEDDSCFTETLAKIYVK
                     QQRYSKALEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(4300..4827)
                     /locus_tag="ctg222_7"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(4814..6055)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg222_8"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(6179..7273)
                     /locus_tag="ctg222_9"
                     /transl_table=11
                     /translation="MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDVQANFSIVNTASEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGDGNKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(7278..8315)
                     /locus_tag="ctg222_10"
                     /transl_table=11
                     /translation="MKKYFFYLSMALVAFVVASCGLKGNHTSSGRPYELLVVVDAGVWD
                     RAAGRALHDVLDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIVIVDIKDIYTKGTF
                     KYAKDVYASPQMILTIQAPNEEVFEKFVEENKQTIIDFFTRAEMNRQITLLEEKHNNFI
                     SNKVDSLFGCDIWIPSELNNSKTGEDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGYKEGVYMSTDSLLTDVRPINVHNDYTMEARGLWRMKGDFMGGPFV
                     SHTRLDQKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPQEGQQSQIPLGVTKEA
                     EPTNK"
     CDS             complement(8333..9370)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg222_11"
                     /sec_met_domain="PF04055 (E-value: 1.1e-17, bitscore: 54.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSKYPLLGMTLIELQSLVKRLGMPGFAAKQIASWLYDKKVTSID
                     EMTNLSLKYRELLKQNYEVGAEAPVEEMRSVDGTVKYLYPVGENHFVESVYIPDDERAT
                     LCISSQVGCKMNCKFCMTGKQGYSANLTAHQIINQIHSLPERDKLTNVVMMGMGEPLDN
                     LEEVLKALDILTGSYGYAWSPKRITVSTVGLRKGLRRFIEESDCHLAISLHSPVTAQRA
                     ELMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCR
                     INLIRFHSIPGVALEGADMDTMTRFRDYLTTHGLFTTIRASRGEDIFAACGMLSTAKQE
                     ENNKS"
ORIGIN
        1 gaactgactg aagagggtct tatcaaatca atcaacgtcc cctacagcag taacaatgca
       61 aagaatgcag caaacaatgc cgttgctccc caacgaaaag ccaatccccg cgactttctc
      121 acagaagaaa ttctgatggc aagttcaacc gccaagatgg ccgaactggt agcaaaggaa
      181 atctataata tccgcgaaag taaaaacgca ttattgcgcg gacaagcaga taatatgcct
      241 tcggacggcg cacagctcaa aatcatgctc gacaacctga atcttcagga agaagccatg
      301 accgagatgt tttcgggagt ccgcaataaa gaagaaaaga catttactgt ccgcctcact
      361 ccggataagg aattcgacaa tgaggtagct ttccgctttt caaagaagct gggtatagtt
      421 gccaacaacg atttggcagg cactccattc tacatcagtc tgaaagacct gaaaacggtg
      481 aagattccgc aagaggacgg gaaaaagaag aaagagatgg aaggcattgc ttataacgta
      541 ccgggacagg caatggtgac gctgacggac ggcaaaaaga aattgtatga aggagaaata
      601 cctgttactc agttcggtat catagaatac cttgctccgg tattattcaa caagaactcg
      661 accatcaaag tttactttga tccggtgacc ggtggactac tgaaagtaga tagagaagaa
      721 agcaaataaa acctctaaaa aaacaaaacg atgggtggcg aaggacatat gctcgacatg
      781 atacgtcggc tgaaagacgg caaagaagcc tcccgcttac gccgtgaacg gagaaatgac
      841 aagttagggc gacttagaag aaacaacgac ccttatcttc tgccggatac gactccggaa
      901 gagatggaac gcatcatcaa ggattcggaa aagaaaaaag aaaaagataa cagctatttc
      961 gtatggggaa cgcttatcat tatgggcgta ctgataggat gtgctgtcct cctgtgggca
     1021 atctttttta atggataatt atccatttaa taaatccgtc tttctgtaat tgggaaagat
     1081 aggtagatac acgagactcg tagcctgctt catattgaaa gtggtctgcg agtttttcta
     1141 taatctcacg aaccgtccgc tgcccgtcta tcaggttcca tacagccgta ccgtgttctt
     1201 ccagacgcac atgaatatct ttggacattc ctttcggcaa taaataacga ctcatccacg
     1261 aacgtttaaa acgagggaag gagagcacaa tagtctcccc ttcctgttca gctttaatat
     1321 gttcgttacg acaagggatc acctccagga ggtttatttt ctctttcgtt gccatatctt
     1381 ttctctttta tatcttttca gatagaatat atactgtgat tatttctgaa tatttgcttc
     1441 ttccagtccg tagcctttct tcttgttttc tgctttcagc atcaaggcaa caatcagggc
     1501 aagtacaccg aacatagcaa aaatagccat cggcaaggta taatcataag tctgtgcacc
     1561 atctacaacc ggacctttgc aataagaatt caacacccat ccaatcagca aaggcacgcc
     1621 catcaatccc cagttctgta cccaaaagat caacgcataa gccgttccca actgtttctc
     1681 cggaataatc ttcggaaccg aaggccacat tgccgaagga accaatgaga aagcaaatcc
     1741 cagaataatc atgatcaccg ttgcaaacca ccagatattc agaataggaa gagcgaacat
     1801 agtgtgtacg aaaatcagca tcaccgaccc gatcaccatc agcgtggctc ccttaccgat
     1861 acggtcatac aatgacccga acaacggtgt caggatgatc gcgccaatcg gcagcaatcc
     1921 gggaatcgtt cccgcaagtt tcggatctac attgtacttc tgtaccatca aatcagccgc
     1981 atacttgatg aaggggaata cagccgaata gaacaatacg cacagtaatg cgatcagcca
     2041 gaatcctttg ttggtaatga tatatacgat gtctttcatg cggaaaggtt cttccggttc
     2101 cagtccttcc gcatccagtg aagcatccag tttcttatca tagaaagtat agatgaagaa
     2161 tgcgatggta cctacgcaca gcatgacgag acagaacaga atcggagcgg gaatattggt
     2221 atggaatacg ccgctctcat ccgtagaccc gaagaagtct gccaaaggaa cggtaagcac
     2281 catggccaaa gttgttccaa tacgcgcggt cgccatttcc agtcccatag cgagagccat
     2341 ctctttgcct ttaaaccact tcacgataat cttcgaaacg gtgatacccg caatttcgac
     2401 tcctacaccg aaaatagcat agcccaatgc agccaatgtg acttgcatct tgaatccgaa
     2461 aagcatcgca ccttccggga aagtagtagt aatagcataa tatttcaatc cacaaccaaa
     2521 caccatcaat aaacaggcac ccattccggt gaagcgtact cccatcttat ccagaatgat
     2581 accaccaaag atgagcatca gcaggaatac attaaaccag ccataagcac tggtgaaaaa
     2641 accgtaatct aaactgtccc agagaagttc tttttcaagc atgggtttca gaggagacat
     2701 aacgtctgtg aggaagtagc cgcacaacat ggtaaaagcg actaatgcta gaacactcca
     2761 acgcagcact gcggagtcat tcagcttttg tttcaattgt tctgtcattg taatatttaa
     2821 aaggagttaa taatctcgta acgggcaaca aagttaacta attatcattt gttttactaa
     2881 aaaaggagaa cattttataa gaaaaaggac atctgaccgg atattcctgt atgaagaaga
     2941 gcagaccgga cccaataata aagataggcg cgaaccacac gtattacaca attctattag
     3001 aatctcttgt aattcgcgta attcgcgcct ataatgaaga gaacgggtca aaaagcccgt
     3061 tcactcaata agtttaaacc gaatatcctg tcactgaatt attctgctgc aggagcagga
     3121 gtttcagtag ccggagcttc tgttgctggt gcagactctg caggagcagt agcgtctgtc
     3181 tgaggagcag cagtaccggt aggcatatta tacggattgg tttgttgttc tttctgtgct
     3241 tgttccaaca atacatcttt agctgcagaa gaagaaggaa caacgtaagc agtagcaacg
     3301 ctcatcacaa ccatgaagat agccagaccc caagttgctt tttccagaaa atctgtagtc
     3361 ttgcgcacgc ccatgatagc gtttgatgaa gaaaaaccag aagcaagtcc gcctcctttt
     3421 gaattctgaa tcagcacgat gaagcacatc agcaaggctg caatcaccat taagataatg
     3481 aataataagt acatttttag ttattttgaa ttagcgttaa taatcaattt ctccaaaaat
     3541 ctgatttggt ctgcaaagta agcatttttt tttggatatt tcaagcttaa ttttttaatt
     3601 atttcaagag ctttcgaata tcgttgctgt tttacgtaga ttttggccaa agtttctgtg
     3661 aaacagctgt catcttcctc ttctacggtg ttggtttcag ttgtttcgtc tgttctgccc
     3721 gtttcgtttg tttcagcgga agaagctgcc tttgctttct cttcttcctt caaaggtttc
     3781 aggtatacga ctggatcagt ctcgcttttt tcgataaagt tgtcaatcag ctcgtgtcct
     3841 ttcaacttgg gcattgcctc tgccggctca tcgacgacag gtgtctcttc gagaaggtat
     3901 gccgtatagt ccatggagta atcaaagctt gtctgactgg ttacttcttc gggagccgtc
     3961 gaaaggaaag catcgatcag agccagtgtc cggtcgacgg taggctcatc tttcaatact
     4021 tcagagagag gcagcccttt cttctgggat tcgacagcga agcgttcgcc ttcgatcaga
     4081 tgaaacagtt tccgtcggtc ggcaatatac agaacggctt tccgcagttc cgcaccgaaa
     4141 ttaatgtcgt ggagaatata caggttcttg agatacaaca accggagcga ctgaaaatac
     4201 ggatacctcg cgagctggtt gcgcagttcg tacaaagtat ccctattcag cgtctcggga
     4261 tgctgaatcc attgttgcaa gttaacagaa gtcattaaat taccagtttg ctacagttgc
     4321 attaaatatt tggtcggtta tctctttact catttccgct attaatccat cctgtacggc
     4381 tgtcagcagc tggctggaat cataggtacg aaaagctgag aattgttgtt cgaagtcttc
     4441 ggcgtgattt gtgttgttga caaagcgtac attgaccgtg atggtcagct tcgtttccga
     4501 agagtaacca tcggcagaca ctgcctggtt atactggttg tagcccgtaa tttcaccgtc
     4561 aatctgcaga tccgcattct ggttcggttt tagcagttgc agacgggtct gtctgatgaa
     4621 gatatctttc aggtcttcat tgaacttggt agccagcgga gcatacacat actccgactt
     4681 aatcgggaaa tcagcaatcg aaatggtctt caccttatcg taattgatag aggagccatt
     4741 aaacttatag gacacactac aggcgatgat gactgccggt aaaacaacca atatcagcgg
     4801 tcgtgctatt ttcttaatcc aattcatatt cttttatttt tctgtaaagg gtacgctcgg
     4861 agatattcag atccttcgcc gcacttttcc gcttaccatg atgcctctca agcgctttac
     4921 gtatcatttc tttttccact tcatcgagcg aaagggtttc ttccacatac tcttccgtgt
     4981 cctgaatatc gtcatcgtct tctttgggac aaacagacgg ttgctgcaca gcatggatta
     5041 tggccggcac ggaaggttgg tgcgtcgttg tcactaccgg agtagctact acctgtccca
     5101 tctgtccgac ttgtcccgca cgttcggcca tcatattgtg caccatcttc ttcagttccg
     5161 ccacttcctg acgcatatcg aacaagacag aatatagtat ttcgcgttcg ctctcaaagc
     5221 tcttgctctc gcgtgtgccg aacagtgccg gaaggcgttg ggtattctgt gccggaagat
     5281 aggtctgcag aatcgcagcc gttatctcac ggtttgtttc tataatcgaa atctgctctg
     5341 tgatgttctt caactgccgg acgtttcccg gccacggata agcaagcaat atcttcttgg
     5401 catcttccgt cagctggata gccggcatcc ggtacttttc ggcaaagtct gcggcaaact
     5461 tacggaacaa caacagcaca tcatctccac gctcacgcaa aggtggtatc tgaataggca
     5521 ccgtgttcaa ccgataatac aaatcttccc ggaagcgtcc ttcggcaatg gcttgtgtca
     5581 ggttcacgtt ggtagctgcc acaatacgta catccgtctt ttgcactttg gatgaaccta
     5641 ccttgataaa ttcaccgctt tcaagtacac ggagcagacg cgcctgtgta ggcaacggca
     5701 actctcccac ttcatcaagg aagatggttc caccgtcagc ttctccaaaa tatcctttcc
     5761 gctcaccaat agcaccggta aatgctcctt tctcgtgtcc gaacagttcg gaatcgatcg
     5821 taccttccgg tatggcacca cagttgacag caatatactg cccatgcttt ctccggctat
     5881 attgatgaat gatctgtgga aaactttctt ttccgacacc actttctccg gtaatcagca
     5941 cagacaaatc ggtaggcgct acctgaatgg caacatctat ggcacgtgat aaggcctcgg
     6001 tattgccaat aataccgaaa cgctgtttca cttgttgtat ctctgctttg gtcatctatc
     6061 ttaatattaa gtaataggta ataagtatta agtaataagt attaagtatt accatcacta
     6121 tcatctcgct tctatccgca tggctaatac ttaatactta ttacttaata cctattactt
     6181 aatcttcgtc tactgtatcc agttttagtt tatcactatc gtcccgtttc tcgtaatact
     6241 gcttccgcaa cgggtttacc cgtgctgctt tctcgcgctg gcggttgcgg aatacatcaa
     6301 ttgctacata aatagcctgg cggaaagagt cttcgctggc cagtccttta ccggcgatgt
     6361 cataggctgt tccatgagcc ggagaggtac gtacaaccgg cagtccggcg gtatagttca
     6421 caccgtcttc catagccagg gctttgaacg gagccagtcc ctgatcatga tacatagcaa
     6481 ggattccgtc aaagtgggta taattgcccg aacccataaa accgtccgca gcataaggac
     6541 cgtaacagat gatccctttc tcttccattt ctttcatggc agggataatg atttcctgtt
     6601 cttccatacc cagcagtccg ccgtctcctg catgaggatt cagtgaaagc actgcaatac
     6661 ggggcgcacc gataccgaaa tcctgtttca ggcaacgatg gaaaatcatc agcttttcct
     6721 gaatcagttc cttggtgatc gttgtggcaa tctcccttac cggaatatgc gtcgttacta
     6781 aagccacacg aaaatcgttt ttcatcagga tcatcagtga cttgtttcca tcgcccagac
     6841 gttcttcaat atactccgta tgaccgggga aagagaactc ttccgactga atggtatgtt
     6901 tgttgatcgg agctgtcaca atgacgtcga tcagcccctc acgatactct tctatggcac
     6961 gttctaaagc acccaatgca gccttacctg cttcgggatc gggtttggag aattccactt
     7021 tcacttcgtc atccgtacag ttcactacac tcagacggtt gtatccggct tcggaagctg
     7081 tgttgacaat gctgaaatta gcctgtacat ccagtgcttt acgatggtaa gccgctactt
     7141 taggtgaacc gtagataatc ggagtacata gctcaagcat ggtagggtct gagaatgtct
     7201 tcaagatcac ttcataacct accccgttga tatctccttg ggtaatgccg attcttattt
     7261 tgttttcttc catgttttta tttattagtt ggttccgctt ctttggttac ccccagtgga
     7321 atctggctct gctgaccttc ttgcggaagt ttcagcgtat aaagagatgc ttccatctgg
     7381 cgaaccagat tgcgtttcat tttatcgggt gaatatacaa atatttctgc tgtaataata
     7441 cgttggttct tctgatccag acgagtatgg gaaacgaacg gcccacccat gaagtcaccc
     7501 ttcatgcgcc acaatccacg agcttccatc gtgtagtcat tgtgcacgtt gatcggacga
     7561 acatcggtca gtaacgagtc tgtcgacata tatacgcctt ctttatatcc ggggatattg
     7621 gctttcatca cggaatcgcg cttatgaaca aagtattctt tggtgaatgt atccttgtca
     7681 gtataaggat aagaatacat cacgaaattg cgatccgcgc tgcctgtatt ggtagatgcc
     7741 cagaagaagt cctctcctgt cttggagtta ttcagttcgg aaggtatcca gatatcgcag
     7801 ccaaacagac tatctacctt atttgagata aagttgttgt gcttttcctc cagcaaagta
     7861 atctgacggt tcatttcagc gcgagtgaag aagtcgataa tcgtctgctt gttttcttcc
     7921 acaaacttct caaacacttc ttcgttcgga gcctgaatgg tcagtatcat ctgtggagaa
     7981 gcataaacgt ctttcgcata cttgaaagta cctttggtat aaatatcttt tatatctact
     8041 atcacaatat tacggatcaa cttcagcgta gaatcatagt ccttcggtga agtatacata
     8101 atccggaaag aaggttccga ctggggcagt cccggcatgt cagaatcaag cacatcatgc
     8161 aaggcccttc cggcggcacg gtcccacact cccgcatcta ctacaaccaa cagttcatac
     8221 ggacgaccgc tagaggtatg attccccttt aatccacaag aagcaactac gaaggctacc
     8281 agagccatgc ttaaataaaa aaagtacttt ttcatgatgt tcgattttta tattaacttt
     8341 tattattttc ctcctgtttc gcagtcgaca gcataccgca tgccgcaaaa atatcctctc
     8401 cccgcgaagc acgaatggta gtgaaaagcc cgtgcgtggt cagatagtca cggaaacggg
     8461 tcatcgtatc catatcggct ccttcaaggg ctactcccgg aatagaatgg aaacggatca
     8521 ggttaatccg gcaatccagt ccgcgaagca gtttgagtaa ctccttggca taaacttgcg
     8581 aatcattaag ccccttaaaa acaatatact caaacgaaag tcgacgctgt ttgctaaaat
     8641 catagttttt taacagttcc accatttccg tgatagaaaa ggctttctcc gccggcatca
     8701 gttccgcacg ctgggcggtc accggagaat gcaggctgat ggcaagatga cagtcgcttt
     8761 cttcgataaa gcgccgcaat cctttccgca atccgacagt tgaaacggta atccgcttcg
     8821 gactccatgc ataaccatag gatccagtca gtatgtccaa tgccttcaac acctcttcca
     8881 gattatcgag cggttcgccc attcccatca tgacgacatt cgtcagtttg tcccgttccg
     8941 gcaaggagtg aatctgattg ataatctgat gggcggtcag gttggcagag tagccttgtt
     9001 tcccggtcat acagaacttg cagttcattt tgcagcctac ctgcgaagag atgcataaag
     9061 tcgcccgttc atcatccgga atatacaccg actccacaaa atgattctcg cccacagggt
     9121 acaggtattt caccgtaccg tctacagagc gcatttcctc caccggagct tcagctccta
     9181 cctcatagtt ctgcttcagt aactcccggt atttcaacga caagttagtc atttcatcaa
     9241 tcgaagtcac cttcttatca taaagccagg atgcaatctg tttggctgca aagcccggca
     9301 ttcccagacg tttcaccagt gactgcagct ctataagcgt cattcctaag aggggatatt
     9361 tagacatcat tctttctgtt catggtttat atttgcaaat gtaaggaaat aaagtcgatt
     9421 tccgtatagc aaggatgtaa aagttagcaa aaaaggtcgt tccaaagcat ggaacgacct
     9481 tttgcagtta tcgattttac gactaatctt agaagaacag gtaacgtgta tccttcactt
     9541 ttcctttcag atacaggtcg ttcatcagac ggcttgcgaa gcgtgcgtgc atgttagcca
     9601 atgtagcttc ttcatcttta gcgttgaaag tatcgctcag tttgtctttg ccatacatct
     9661 gaagcacaaa tacaccggca ttacctttga tcggagcgct cagtttgttc atttcagcca
     9721 cagaagcata agcacctacc aacggttcgc tgctgcgcaa tgcagaaaca taagcgggag
     9781 cggcaaatgt aaccagcttc aaagaatcgc tgactgcgcc ggacatagcc ttgtactggt
     9841 cgagagaagt tgcattggca gccttcatgt cagccatgat cttttcggct ttcttatctt
     9901 taacgatttc agctctcaac tgatcctgta cagcttttag cggacgatat ccttccggag
     9961 taacaccaac cagagctact gcaaccatat ggtcgctttc gccacattca tacaaaccgg
    10021 aaacatcacc cggtttagcg gcaaatgccc atctcaatgc ttctttagta cctcttacac
    10081 caccgatagt gtgttctgag ctatacaagt ctcttctgtc aagcagtttg tatccggctt
    10141 cttcagcgtt agcgatcatc ttttcagcag taggattggc agcgatgaac tggctgaaat
    10201 cattgtaagc acgattataa gtctctttgc tgaattcaac ttcacgtttc acaacagcta
    10261 ctttatattt atccttcaca gctttcttgt tagtcacttg caggattaca ttagcttgtc
    10321 ccaacggcag atttactact tcgttcacgc ctgtattatt gatagcagag ataaacttca
    10381 ggttgtcacc atcgatctgt gcgccttcat actgtgcaga gctcatccag ttagtctcac
    10441 ccgtctgacc gtatttctta gccagatctg cgaagttagc accgcctttg atagcagtat
    10501 agatactgtc cgccaaggct tttgtcttca aagcgtcttc tgcaaacacc tgaatctgac
    10561 ggaactcgat tgagtcggca gcagctgttt ttgcaaccac tttgaatgaa ttgatagtat
    10621 tgtcggcacc attatagtac ggaccataaa cagaaccaac ggatgcagag tccagacggg
    10681 caactacatc tgacgggaaa gctgttttat tatagaacaa gtctacataa ggagcttccg
    10741 agcctacaga acggataaaa gaagtatagt catctgttgt agtagccagc tgtgcagtag
    10801 cttcgtctac ttcctgctgg atagcagctc tgtcttccgc acttgcagtc acctgaacat
    10861 caatgtactt gatatcacgg ctttcctgat attgcttgaa ctgttctttt ttcttgttat
    10921 aaaggtcttt cagttccgat tctttcacaa cgattgtaga atctactata gaagaataag
    10981 gaacggcagc catcaacaaa tcatattgat tcactcttgc gtcgaaagcg tcctgtgctt
    11041 ctaccgggtt agagagaagc gcttttgcta ccaatgcctg atatttttct gccaggcggc
    11101 tctgaatcaa tgtcttctgg atgaatgacc agtatttgta catgttgttg tactgttctg
    11161 catactgagc cggcatctga gattcgttca ttttagcgta atctaccagg aacttattga
    11221 gcatatcctt atcgaaagca ccggtctgcg ggttgcggaa aggagtctgt tgcaacaacg
    11281 gatgcacgcc tgctttcagg atatcctgaa tttcagcagc agaaactgtc agtcccaatg
    11341 cttttgcttc tttctcaacc agtttgttat taacg
//
