LOCUS       c00196_gnlPro..        12016 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LFPJPPAG_196.
ACCESSION   c00196_gnlPro..
VERSION     c00196_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:01:01
            Original ID  :: gnl|Prokka|LFPJPPAG_196
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12016
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..780
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg196_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-47, bitscore:
                     150.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNRHTEWVDSFKEY
                     EAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMISARYFKYTRE
                     RSIVTSGGLGTMGFGLPAAIGATFGRPDRIVCVFMGDGGLQMNIQELGTIMEQKAPVKI
                     ICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDE
                     MLSTDGAFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     protocluster    1..12016
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3212]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..3212
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12016
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12016
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             799..1362
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg196_2"
                     /sec_met_domain="ALS_ss_C (E-value: 4.9e-20, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             1362..2105
                     /locus_tag="ctg196_3"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEA
                     NENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             2169..3212
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg196_4"
                     /sec_met_domain="IlvN (E-value: 2.9e-47, bitscore: 149.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.6e-40, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             4013..5875
                     /locus_tag="ctg196_5"
                     /transl_table=11
                     /translation="MRSYSCILKVIVVYALLGIVIASCIDKDTDYSRPDDPQTPNDFDY
                     STTQQVQLNVQYEVPEGYQVLFDVYFENPFEIDEEGQVVKRTDVVPKVTRMTDGNGKYA
                     GLEVIPGYLDGDIYIYSSYIGVPTLYKTTLQGNKIQADISWDTMYDFVSAAPTRVESNF
                     TYPKAFNILGDWDENGRPDYLDSEGALSLSQPIMNAINRTLPEDGKCPQKYRQSVDFEI
                     KEPAHVKVRFIGGKSSAYSTFGYYCYKADASIGEIKKAKKYIVFPNTRTGIGLKGGECV
                     ALHYIDENGVDRGTDFPKGIKIGWFIRNAAFWKGNIGEGKGMFYSTPKLNTDGRTHTVA
                     FRINDFVVLSFEDWTDEDYNDVMFNVWSDPIKAIVTPNLPEVIPPGNPDDSSIAYSMTY
                     KGILAFEDNWPSKGDYDLNDVVVKYNSVLSFNTKNEVLSTKDTFTALWSGASYSNSFIY
                     QLNTDKLNVESSLEVDQDLALATIPVFVDVKTATGDNTKTSTVNVTNKFKTPVDHEVLG
                     GAPYNPFISVFKYTGYDRTEVHLVNHKPTEKAKKALFHTGEDLSDLNAGIYYVSASKYP
                     FAINLSDAEVYSTEEREAVDKTYPRFVSWAESNGAKDKDWYLGK"
     CDS             complement(5934..7877)
                     /locus_tag="ctg196_6"
                     /transl_table=11
                     /translation="MKYIFVSGGRFTTFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHPSYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLITYIKQSSLS"
     CDS             7944..10187
                     /locus_tag="ctg196_7"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DVKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDEFMQIGAVIMANACGPCIGQWKRHTDDPMRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPEGEELPLRGFTSGNEG
                     YIAPGGTKTAINVNPASQRLQLLTPFPAWDGQDILNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNNVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQEHD
                     LLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             10217..11392
                     /locus_tag="ctg196_8"
                     /transl_table=11
                     /translation="MQKDGTLSVPDVPVVPYIIGDGVGAEVTPSMQAVVNAAVQKAYGG
                     KRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLNVALRQ
                     TLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEKFYQFL
                     KNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTE
                     GGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVS
                     DQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVMMLEYL
                     GWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK"
     CDS             11418..12014
                     /locus_tag="ctg196_9"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFCELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIR"
ORIGIN
        1 gatccggcgg aagtaaataa gaatgtaaag gtagatattg ccgttttggg cgactgcaaa
       61 aagacgctgg ctgctgtgac cggactgttg aaaaagaacc ggcacaccga gtgggtcgat
      121 agtttcaagg aatatgaagc ggtagaggaa gaaaaagtca ttcgtcctga acttcatcct
      181 gcaacggatt cactgagtat gggcgaagtg gtgcgtgcgg taagcgaagc gacccgtcac
      241 gaagccatat tggtgacaga tgtaggtcag aatcagatga tctctgcccg ctactttaaa
      301 tataccaggg aacgtagtat cgttacttcg ggtggactcg gcacgatggg ttttggcctt
      361 ccggcagcta tcggagctac tttcggccgt cctgaccgca ttgtatgtgt atttatgggt
      421 gacggcggac tgcaaatgaa cattcaggaa ctgggtacga tcatggaaca gaaagctccg
      481 gtgaagatta tctgcctgaa caacaattat ctcggcaacg tgcgccaatg gcaggctatg
      541 ttctttaatc gccgttattc atttactccg atgctgaatc cggattacat gaaaatcgct
      601 tccgcctacg atattccttc caaacgtgtc ttttcacggg aagaattgaa agcggccatc
      661 gacgaaatgc tctcgacaga cggggcgttc ctgctcgaag cctgtgtggt agaagaaggc
      721 aatgtcctcc cgatgacccc tccgggcggt tcagtcaatc agatgttgct ggaatgttaa
      781 tccttaattt agaaagttat gagtgataag acattatata cgattatagt tcattctgaa
      841 aatatagccg gattgctgaa tcaggtgacg gctgtattta cccgtcggca aataaacatc
      901 gagagtttga acgtttctgc ttcttccatt aaaggagtac ataaatatac gatcacagcg
      961 tggactgata aggacactat tgaaaaggtg gtgaagcaga tcgaaaagaa gattgatgtg
     1021 attcaggcgc actattttac ggaagacgag atttatttcc atgagatagc cttatataag
     1081 gtatctactc ctgcttttca ggagactccg gaagcatcta aagtgattcg cagatataat
     1141 gcccgcattg tagaggtgaa tccggtattc tctatcgtcg agaagaacgg catgagtgaa
     1201 gagattactt ccctttacga agaacttcgg gctttgaaat gtgtgctgca atttgtccgt
     1261 tcgggccgtg tggctattac taccagctgt ttcgaacgtg tgaatgagtt cctggacgga
     1321 caggaagcga agtataagca aagtaaaaag gaacaggagt aatgagtgaa gaaaataaaa
     1381 tagggactta tcagtttgtg gcagagccgt ttcacgtaga ttttaacggc cgcctgacca
     1441 tgggcgtgct ggggaatcat ctgctgaatt gcgcaggttt tcatgccagc gaccgtggat
     1501 ttggtattgc tacgctgaac gaggacaatt acacatgggt gctttcccgc ttggcgatcg
     1561 agctggatga gatgccttac caatacgaga agttctcggt tcagacatgg gtggagaatg
     1621 tctatcgtct ctttaccgac cgtaactttg ccgtcattga caaggatgga aagaagatcg
     1681 gctatgcccg ttccgtatgg gcgatgatca atctgaatac ccgtaagcct gccgatctgt
     1741 tggcattgca tggaggaagc atcgtcgatt atatatgcga tgaaccctgc ccgatagaaa
     1801 agccttcgcg tatcaaggtg acaagcaatc agcctgttgc gacgctgacg gcaaaataca
     1861 gtgatatcga tattaacgga cacgtaaaca gtattcgtta tatcgagcac atacttgact
     1921 tgtttccgat agaactgtat cagacgaaac gtatccgccg gtttgagatg gcgtatgtgg
     1981 ctgagagtta tttcggagac gaactctctt tcttctgtga tgaggcgaat gaaaacgagt
     2041 ttcatgtaga ggtgaagaaa aacggcagcg aggtagtatg ccgttccaaa gtgatatttg
     2101 aataatatag agtataaaat caattaataa cagatggcgc aagtcatcaa aacaaaaaaa
     2161 caaaaaaaat ggcacagttg aattttggcg gaactgtaga aaatgtagtt atccgtgatg
     2221 aatttccatt ggaaaaagct cgtgaagtat tgaaaaatga aacaatcgct gtaatcggtt
     2281 atggcgtaca aggtcccgga caggctctga accttcgtga taacggtttc aatgtaatcg
     2341 ttggtcaacg ccagggaaag acatatgaca aagcggttgc tgacggatgg gttccgggtg
     2401 aaactttgtt cggtattgaa gaagcctgcg aaaaaggtac gatcattatg tgcctgttgt
     2461 ctgatgcagc agtaatgtct gtatggccta ctatcaagcc ttacctgact gcaggaaaag
     2521 ctctttattt ctctcatggt tttgctatta catggagtga ccgcacaggt gtagttcctc
     2581 ctgcagatat cgacgtaatc atggttgctc ctaaaggttc gggtacatcc ttgcgtacta
     2641 tgttccttga aggtcgcggc ttgaactctt cttacgctat ctatcaggat gcaacaggca
     2701 acgctatgga cagaacaatc gcattgggta tcggtatcgg ttcaggttat ttgttcgaaa
     2761 caactttcat ccgcgaagct acttccgacc tgacaggcga acgtggttca ttgatgggag
     2821 ctatccaggg tctgttgctg gcacaatacg aagtgttacg tgaaaacggt catactcctt
     2881 ccgaagcatt caacgaaact gtagaagagc tgactcagtc attgatgccg ttgtttgcaa
     2941 agaacggtat ggactggatg tatgctaact gctctactac agctcaacgt ggtgctctcg
     3001 actggatggg ccccttccac gatgctatca aaccggtagt tgaaaagttg tatcacagtg
     3061 tgaagactgg taacgaagca cagatttcaa tcgactctaa ctccaaaccg gattatcgtg
     3121 agaaactgga agaagaactg aaagcattgc gcgaaagcga aatgtggcag actgccgtga
     3181 cagttcgtaa acttcgtccg gaaaataatt aatcagactt atactatata agtttttcaa
     3241 aaggcgggaa aagcgtattt tcccgccttt tctatgtaga taccggtctt ttgagtaata
     3301 gaaaaaggat gaaagtagaa aaaaagatta aaagatactg ataatatagg tgaaaaagag
     3361 catttatgat tacctttacg gcaacaaata aaacagaata ggcaatgaag aaacttttta
     3421 cttacagaag atcgatacgt atgaagatga tttcttcttt aataaatagt atatcagaat
     3481 gttacattaa aagatattta agttattctc taccgaatgg tagctgtaat accatttcaa
     3541 gtccttttta tatttcgtgt tccattagtg attcgttgat atgatgcaga attttattct
     3601 gtagcaggaa aaagtatgcg ttaaattgaa tttaagacag agcttttgga acagaattta
     3661 gtgggaaaat aacattgttt gttttgtttg taaatgggag tcctctttcg tgagaaaggg
     3721 ggcttctttt tgatatgctc aacataggtg catgttttag gattgattcc tctcatccat
     3781 aaatatctga acgttggtgt tgtggtaggc actaggattg catcaactcc tgccggagtt
     3841 gctcaagggg agattgagtc tgaaaaacag taaatatggt tatattttat aacttcacga
     3901 aaggttggag aatatatatt ttcgtctttt attgaaaaaa tattagaatt atgcataaga
     3961 tatgcaagtt tgtatttatc tttgcttcaa caaactaaaa caaattttaa aaatgagaag
     4021 ctattcatgt attttgaaag taatagttgt ttatgcctta cttggtattg ttattgcaag
     4081 ttgtatcgat aaagatacag actattctcg tccggatgac ccccaaactc ctaatgactt
     4141 tgattacagt acaactcaac aggtacagtt aaatgtgcag tatgaggttc ctgaaggtta
     4201 tcaagtactc tttgatgtct attttgagaa tccatttgaa atagatgaag aaggccaagt
     4261 tgtaaaacgt actgatgttg tgccgaaagt gactagaatg actgatggaa atggtaaata
     4321 tgccggcttg gaagtgattc ccggttattt ggatggtgac atttatattt attcttctta
     4381 tatcggagtg cctacgcttt ataagacaac tcttcaggga aataagattc aagctgatat
     4441 atcctgggat actatgtatg attttgtttc tgcggctcca acacgagtgg aaagtaattt
     4501 tacgtatcca aaggctttta atatattggg tgactgggat gaaaatggtc gtcctgatta
     4561 tttggatagt gagggagcgc taagcttgtc tcaaccaata atgaatgcaa taaaccgtac
     4621 acttccggaa gatgggaaat gtccgcaaaa atatcgtcag tcggttgatt ttgaaataaa
     4681 agagcctgcc catgtaaagg tacgttttat tggcggcaag agtagcgctt acagtacatt
     4741 tggatattat tgttacaaag cggatgcttc tattggagaa attaagaaag ccaagaagta
     4801 tattgttttt cctaatacaa gaactggaat agggctaaaa ggaggggaat gtgtcgcgtt
     4861 acattatatt gatgaaaatg gggtggatcg tggaacagat tttcctaaag gtataaaaat
     4921 aggctggttc attaggaatg cagctttttg gaaaggaaat attggtgaag ggaaaggaat
     4981 gttctactca actccaaagt tgaatactga tggacgaact catactgttg cttttagaat
     5041 taatgacttt gttgttctct cttttgaaga ctggactgac gaggattata acgacgtgat
     5101 gtttaatgta tggtcagatc ctattaaagc tattgttact ccgaatttgc ccgaggttat
     5161 tcctcccgga aatcctgacg atagttcaat tgcatatagc atgacttaca aaggtatttt
     5221 ggcttttgaa gataactggc cgtccaaggg ggattacgat ttgaatgatg tagttgtaaa
     5281 atacaattct gtattaagtt ttaatacaaa gaatgaagtg ctttctacga aagacacgtt
     5341 tactgcattg tggtccggag cctcttatag caatagtttt atttatcagt taaatactga
     5401 taaattgaat gtcgaatcgt cacttgaggt agatcaggat ttggctcttg ctactattcc
     5461 ggtatttgtg gatgttaaaa ctgcgacagg cgataatacc aagacatcaa cagtgaatgt
     5521 cacgaataaa tttaagactc ccgtcgatca cgaagtctta ggaggagctc cgtataatcc
     5581 atttatcagt gtttttaagt atacgggata tgaccggaca gaagtacatt tagtcaatca
     5641 taaacctacg gagaaagcga agaaagcttt gttccataca ggtgaggatt tatccgattt
     5701 gaatgctggg atttattatg tatctgcttc aaaatatccg tttgcaatca acttatctga
     5761 tgcagaggtc tattcgacgg aggaaagaga ggcagtagac aagacttatc cccgctttgt
     5821 ctcctgggct gagtccaatg gagcaaagga caaagattgg tatttaggaa aataatatag
     5881 tttgttttgt tagtaagtgg ggtttttctt cgactgaagg agaccccctt attttatgat
     5941 aggctgcttt gtttgatata tgtaattaat ttccggtaga acgcatgctt ggtaagagtg
     6001 gttgcatctc ccaaaatcac aagtttcatc cgggcgcggg taatggctac gttcattcgt
     6061 cttaaatcat tcagaaaacc gatctgtccg tcctcgttcg cccggacgag gctgataaag
     6121 acgacatccc gttcctgtcc ctgaaagccg tctaccgtgt tgaccgtgat gaggctgcgg
     6181 aaagggcgga gaaaactgct tcctctgatt ttacttctca ggtattgcac ttgcgccttg
     6241 tagggcgaaa tcagaccaaa gtcgatgctc tcgtccagga tgcgtgcttt gccgatccgg
     6301 ctgatatagg cttccagttc ttgcagtaac aagttggctt cctgcttgtt gatacgcccg
     6361 aagctctcgc ctacaaactc ttcgtggaag tccatttccg aggtatctat ccagttcatg
     6421 ggagtgtcga agtcaaggat accccggttg cgcacttccg gtgcggcttc cagttctccg
     6481 ttgtagaacc attcggaggg aaagcgcatg attgcctcgt gcatccggta ttgcactttg
     6541 agcagcgaga cggcagaagg tttttgctgc acgacttttt ccattaaagt atggtccagt
     6601 ccgccacggg cggcttcgat acatttgatt gtaggaggga gctggcaatg gtcgccggca
     6661 agaatcacac ggtcggcctt tcggatggcg atccaacagg cggcttcgag tgcctgggcg
     6721 gcttcatcga taaataaggt ggggaaacgc cttccgttga gcaaacggtg attgctgctg
     6781 accagcgtag aagcaatcac acgggcactg tcgaaaagat cggcgttgat caggatttcc
     6841 agttcggtgg cacggtcgcg gaggcggctc atccggctgc gcattccttc cctttcggag
     6901 taacttcccc gacgcatccg gctgcccatt tcacggattg attttcggat tccccaaagt
     6961 tcggggtagc tcggatgatt ctcaaagcgg cgttcgtagg tgaaagagag cattttatca
     7021 ttaacacgcg taggattacc aatgcggagc acaggaacac cccggtccac cagtttctca
     7081 caaatccagt ccacggccgt attactttgg gcgcagacca gcacctgcgg ttcgcggtga
     7141 agcgtttcgt aaatggcttc cacaagcgtg gtagtctttc cggttcccgg agggccgtgt
     7201 acgatggcga catcgcgtgt gcataacact ttgtttacgg ctgtctcctg cgtgctgttc
     7261 agccacggga aacggacggg atacaattcg cggaatcccg gcttttgtgt tcccagcaag
     7321 gtgtcccgga gttcggcaag gcggttgcct ttggcgcgga tcgtgtcttc cagcgcttcg
     7381 aacatggcac gataggacgt ttcatcgaaa taaagttgta cacccagcac ctcttccgtt
     7441 tgcagttcca gcaatgcgcc tgcactggga agcacgacca ccatccgttc atcgtctgca
     7501 taactcaccg ttgcaatgaa gttcatataa ttcacttttc cgtcaaatga ctgacggaaa
     7561 aagcagacgg gacgaccgaa ttcgaaggaa tgctcgattt ctttattttc ggtgcgtgta
     7621 atatctatta caagttgatt tagagaatta tagtaacttc gaccgggaga ggcgggatac
     7681 cagcacagac cacgtttcac tttgcgggcg acacccattg tttcagtctg ccgcttgaat
     7741 tcctcctttt cgtgttcata ctccatgcgt agcaggagtt gctgttgctg aaggtcgatg
     7801 attggacttt tcggatgatt attcataata gatgcaaagg tagtaaatct tcctcctgag
     7861 acgaaaatat atttcatatt gttaaacatt cctcgaacgc cgttcgttat ttttatagat
     7921 agactaaaaa aaataaaagc aatatggtgt atgatttgac tatgttagag gctttttatt
     7981 ctgcttataa aggaaaagtg gaacacgtgc gggctgtttt gaaacgccct ttgacgttag
     8041 ccgagaagat tctgtatgcc cacctgttca atgagggcga tgtgaaaaac tacaaacggg
     8101 gtgaagacta cgtaaatttc cgtcccgacc gcgtcgctat gcaggacgcg actgcccaga
     8161 tggcattgct tcaattcatg aatgcaggaa aagaaaaagt ggctgttccc tccaccgtgc
     8221 actgtgacca cttgatacaa gcgtacaaag gagcaaagga ggacattgct acggcaacca
     8281 aaacaaacga agaagtttac gactttttgc gcgatgtatc ctctcgttac ggcatcggct
     8341 tctggaagcc gggcgccgga atcattcatc aggtagtgct cgaaaattac gctttccccg
     8401 gtggaatgat ggtaggcacc gactctcaca ctccgaatgc tggaggattg ggcatggtgg
     8461 ccatcggtgt cggcggtgcg gatgccgtag acgtgatgac aggtatggaa tgggaactga
     8521 aaatgccaag gattattggt gtccgcctga ccggaaaatt gagcggctgg acttccccga
     8581 aagatgtcat cctgaaactt gcagggattc tgaccgtaaa aggaggaacg aactccatca
     8641 tcgaatattt cggaccggga acggcttccc tgtcggctac cggcaaagct accatttgca
     8701 atatgggtgc ggaagtagga gctaccactt cgcttttccc gttcgacggg cgcatggcta
     8761 cttatctgag agccactggc agagatcgta tcgtggaact ggcggaagcc gtggactgtg
     8821 aactccgtgc ggaccaacag gtgacggacg aaccggaaaa gtactacgac cgtgtcattg
     8881 acattgactt gtccacgctc gaaccttaca tcaacggccc tttcacaccg gatgccgcta
     8941 cccctatctc tgaatttgca gaaaaagtat tactgaacgg ctatccgcgt aagatggaag
     9001 tcgggctgat cggttcgtgt accaactctt cttaccaaga tctcagccgt gccgcatccc
     9061 ttgcaaggca ggtgaaggaa aagaatctga gtgtggcttc cccgctgatc atcaatccgg
     9121 gttccgaaca aattcgcgcc actgccgaaa gagacggaat gatggatgaa ttcatgcaga
     9181 tcggcgccgt gatcatggca aatgcctgcg gtccttgcat cggtcagtgg aaacgtcata
     9241 cggacgaccc gatgcggaag aactcgatcg tcacctcctt caaccgtaac tttgccaaac
     9301 gtgcggacgg taatccgaac acatacgcct ttgttgcttc tcccgaactg acgatggcac
     9361 tgaccattgc cggtgatctt tgcttcaatc cgctgaaaga cagactgatg aatcatgatg
     9421 gcgaaaaagt gaaactggcc gaaccggaag gcgaagaact ccccttgaga ggatttacct
     9481 ccggtaatga aggctatatc gcccccggcg ggacgaaaac tgcgatcaac gtcaacccgg
     9541 cttcccaacg cctgcaactg ctgactcctt tccccgcttg ggacggacaa gatatactca
     9601 atatgcccct gctgattaag gcgcagggca aatgtactac cgaccatatt tcgatggcgg
     9661 gaccgtggct gcgttttcgc ggacatttgg agaatatttc ggataatatg ctgatgggag
     9721 ccgtgaatgc tttcaatggc gaaacgaaca acgtgtggaa ccgttcgaca aacacctacg
     9781 gaaccgtttc gggcacagcc aaaatgtata aatccgaagg aatcccctcc attgtcgtgg
     9841 ctgaagaaaa ttacggagaa ggctccagtc gcgagcacgc ggcaatggaa ccccgtttcc
     9901 tgaatgtgcg tgtgattctc gccaagagct tcgcccgtat ccacgaaacg aatctgaaaa
     9961 agcaaggcat gcttgccctt acttttgcgg acaaagcgga ttatgacaag atacaggagc
    10021 acgatctcct ttcagtcatc ggcttgcccg actttgctcc gggacggaat ctgaccgtcg
    10081 ttctccatca cgaagacgga acgaaagaga gttttgaagc gcaacataca tacaacgaac
    10141 agcagattgc ctggtttcgt gccggttctg ccttgaatgc cagataatta aaatgataga
    10201 aatgaacaaa ataaccatgc aaaaagatgg tacgctatcg gtgcccgatg tgcctgtcgt
    10261 accttatatt atcggagacg gagtaggagc ggaagtgacc ccgtcgatgc aagccgttgt
    10321 gaatgcggct gttcagaaag catacggcgg caaacgtcgg attgaatgga aagaagtgct
    10381 ggcgggcgaa cgcgctttca acgagacagg ctcttggctg ccggatgaaa cgatgaaggc
    10441 tttccaagaa tatctgatcg gcatcaaggg tccgctgacg acccctgtcg gcggtggaat
    10501 ccgttctttg aacgtagctt tgcgccaaac cttggattta tatgtttgtt tgcgtccggt
    10561 tcgttggtat caaggcgttc attctccggt gaaagcaccg gaaaaagtga acatgtgcgt
    10621 gttccgtgaa aatacggagg atatatatgc aggaatcgag tgggaggcag gtactcccga
    10681 agctgaaaag ttctatcaat tcctgaaaaa cgagatggga gtgacgaaag tccgcttccc
    10741 cgagacctct tcttttgggg tgaaacctgt ttcccgtgag ggcacggaac gtcttgtgcg
    10801 ggctgcctgc cagtatgcgc tcgaccatca tctgccttct gtgacactgg tgcacaaagg
    10861 aaacattatg aagttcaccg aaggaggttt caagaaatgg ggctatgagc tggcgcaacg
    10921 tgagtttggc gacgcgctgg cagacggccg gctggtgata aaggactgca ttgccgatgc
    10981 ttttctgcaa aatacattac tgattcccga agagtattcc gtgattgcca cgctgaacct
    11041 gaacggagac tatgtttccg accagttggc ggcaatggta ggcggcatcg gcattgctcc
    11101 gggagcaaat attaactaca agacggggca cgccattttt gaagcgactc atggaaccgc
    11161 ccccaacatt gccggaaagg atgtcgtgaa tccttgttct atcattcttt cagcggtgat
    11221 gatgcttgaa tatctgggat ggaaagaagc ggccgcgctt atcgaaaagg cgctggaaca
    11281 gagtttcctc gatgcccgtg ccacgcatga tctggctcgc tttatgccgg gaggtacatc
    11341 cctgtctacc accgctttca cacgcgaaat tgtggaaaga atcgaaaagt aaatgtaacg
    11401 attaaaaacg aagtattatg aagaaagagt atttgattta caagctctcc gaggagatga
    11461 aagaggcaac ccggattgac aatgaattgt tccccaagtt tgacgtgaag cgtggactac
    11521 gtaatgaaga cggcaccggt gtattggtag gtctgacaaa gattggtaat gtggtgggtt
    11581 acgaacgtat ccccggcggc ggtctgaagc ctattccggg aaaattgttc tatcggggct
    11641 atgatgtgga agacatttcc cacgccatca tcaaggaaaa acgtttcggc ttcgaagaag
    11701 tggcttatct gctactctcc ggtcgcctgc cggacaagga agaactggct tcgttctgcg
    11761 aactgatcaa tgacaatatg gcgctcgagc agaagacgaa aatgaatatt atcgagcttg
    11821 agggaaataa tatcatgaat atcctttcgc gcagcgtact cgaaatgtat cgtttcgatc
    11881 ccgatgccga cgatacttcc cgcgacaatc tgatgcgcca gagtatcgat cttatctcca
    11941 agttcccgac catcattgcg tatgcctata atatgctccg ccatgctaca ttcggccgtt
    12001 ccctgcatat ccgtca
//
