LOCUS       c00376_gnlPro..        14457 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LFPJPPAG_376.
ACCESSION   c00376_gnlPro..
VERSION     c00376_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:01:01
            Original ID  :: gnl|Prokka|LFPJPPAG_376
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3556
            Orig. end    :: 18013
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14457
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[13556:17718]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14162
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14457
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14457
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             978..2036
                     /locus_tag="ctg376_4"
                     /transl_table=11
                     /translation="MKKKLTGVALVLAAVSLMGIQPAEACTRAVYLGPDGMVVTGRTMD
                     WKEDIMSNIYVFPRGMQRAGHNKEKTVNWTSKYGSVIATGYDIGTCDGMNEKGLVASLL
                     FLPESVYSLPGDTRPAMGISIWTQYVLDNFATVREAVDEMKKETFRIDAPRMPNGGPES
                     TLHMAITDETGNTAVIEYLDGKLSIHEGKEYQVMTNSPRYELQLAVNDYWKEVGGLQML
                     PGTNRSSDRFVRASFYIHAIPQTADAKIAVPSVLSVMRNVSVPFGINTPEKPHISSTRW
                     RSVSDQKNKVYYFESTLTPNLFWLDLKKIDFSPKAGVKKLSLTKGEIYAGDAVKDLKDS
                     QSFTFLFETPVM"
     CDS             complement(2162..3526)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg376_5"
                     /sec_met_domain="Peptidase_M20 (E-value: 1.2e-38, bitscore:
                     122.9, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIQKYIAANEPKIMEDLFSLIRIPSISALPEHHDDMLACAQRW
                     AQLLLEAGVDEALVMPSKGNPIVFAQKIVDPNAKTVLVYAHYDVMPAEPLELWKSQPFE
                     PEVRDGYIWARGADDDKGQSFIQVKAFEYLVKNELLKNNVKFIFEGEEEIGSPSLEAFC
                     EEHKELLKADVILVSDTSMLGAELPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVAN
                     PINVLCEIISKVTDKDGRITAPGFYDDVEEVPQAEREMIAHIPFDEKKYKEAIGVKELF
                     GEKGYSTLERNSCRPSFDVCGIWGGYTGEGSKTVLPSKAYAKVSCRLVAHQDHHKISQM
                     FADYILQMAPDTVQVKVTPMHGGQGYVCPISLPAYQAAEKGFEIAFGKKPLAVRRGGSI
                     PIISTFEQVLGTKTVLMGFGLESDAIHSPNENFSLDIFRKGIEAVIEFHQEYAKR"
     CDS             complement(3628..4704)
                     /locus_tag="ctg376_6"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGVGGVIDGFPSGITIDEEFVQQELN
                     RRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHSNDYNNLKEVYRPS
                     HADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGISITAYTSQVGAIKL
                     EGTYSDYDLDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQ
                     PVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFFNNNGRIETHTNHSGG
                     IQGGISNGQDIYFRVVFKPIATLLMEQETVNIDGVDTTLKARGRHDACVLPRAVPIVEA
                     MAAMTILDYYLLDKTTQL"
     CDS             4863..5426
                     /locus_tag="ctg376_7"
                     /transl_table=11
                     /translation="MKKNLLYLWALICSVSLLTACSSDDDNTVNDETTPPEEEAVVTAP
                     DVVGTYWGNLDISMLPDGSDQEVVIADGLPKFITFSQVSDTEVKMELKEFELFINGNIL
                     KFGDIVIDKCAVKKETDASTFTGQQDLTFQGDAAALGTCATSIEGTVQGGNATMNIQVK
                     VPALQQTVKVAFSGVKQVEESGKD"
     CDS             complement(5442..6227)
                     /locus_tag="ctg376_8"
                     /transl_table=11
                     /translation="MKIHSYIFSLLACLVIALPGYSQVDRNETLIRSALHGLEYEIKAG
                     VSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWFAVQNKLGVIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTSGLTIPLMATYKLSNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREGDPVGPKVEFTDGKIATYDFSDDLRHFQWGLQIGAGWRAFKH
                     LNIYADLTWGLNDIFRNDFQTITFAMYPIYLNIGFGYAF"
     CDS             complement(6318..7403)
                     /locus_tag="ctg376_9"
                     /transl_table=11
                     /translation="MKAKHGILYLLLAIFSSSCIREEAPNAEADILSCRLPGVVMTTSP
                     IITNNSINIFVGPGTDISSLAPEFTLTPGATIDPPSGTARDFHSPQQYTVTAADGFWKK
                     KYTVSVIDTELATIYNFEDTLGGQKYYIFVEREGEKVVMEWASGNAGYAMTGVPKTADD
                     YPTFQFANGKTGKCLSLVTRSTGFFGSIMGMPIAAGNLFIGSFDVGNAMSNPLKETKFG
                     LPFRHIPTYLAGYYKYKAGDQFTEGGKPVSGKRDICDIYAIMYETSESVPTLDGTNAFT
                     SPNLVSIARIDDAKETDEWTYFKLPFHMLSGKYIDKEKLTAGKYNVAIVFTSSLEGDHF
                     NGAIGSTLLIDEVELIYRSED"
     CDS             7537..8826
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg376_10"
                     /sec_met_domain="SDH_alpha (E-value: 1.2e-62, bitscore:
                     201.8, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIESERKQIIDLIKKEVIPAIGCTEPIAVALCVAKAAETLGMKPE
                     KIEVLLSANILKNAMGVGIPGTDMVGLPIAVALGALIGRSEYQLEVLRDCTPEAVEQGK
                     LFIAEKRICISLKEDITEKLYIEVICTAGSQKATAVIAGGHTTFVYIATDEKVLLDKQQ
                     TANEEEEDASLELNLRKVYDFALTSPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKTEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SIRNLTRIGSQAMNETDKMVLDIMTHKGGC"
     CDS             complement(8951..9526)
                     /locus_tag="ctg376_11"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTVEDGEKELFEETNAEHPFQFISGLGTTL
                     ESFENQITALSKGDKFDFTIPADEAYGAYDEQHVFDLPKNIFEIDGKFDSERVTEGSIV
                     PLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEVIESRPATNEEIQELVKMM
                     SGEGCGCGCDSCGSDCGDDCGCEGGHCH"
     CDS             10001..11803
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg376_12"
                     /sec_met_domain="ILVD_EDD (E-value: 5.6e-218, bitscore:
                     714.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGG
                     LIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRLID"
     CDS             11851..13548
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg376_13"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-47, bitscore:
                     150.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDVAVLGDCKETLASVTKLLKKNT
                     HTEWIDSFKEYEKVEEEKVIRPELHPATNSLSMGEVVRAVSNATQHEAVLVTDVGQNQM
                     ISARYFKYTKERSIITSGGLGTMGFGLPAAIGATFGAPERTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKVASAYDIPSKRAF
                     TREELKEAIAEMLATDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             13605..14162
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg376_14"
                     /sec_met_domain="ALS_ss_C (E-value: 4.5e-19, bitscore:
                     58.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITALTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKLIRRYNARIVEVNPVFSIVEKNGMSEDITSLYGELKALNCVLQFVRSGRVAITTS
                     CFERVNEFLDGREAMYNQSKNQ"
     CDS             14168..14455
                     /locus_tag="ctg376_15"
                     /transl_table=11
                     /translation="MSEENRIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHANDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYENFSVQTWVENVYRLFTDRNF"
ORIGIN
        1 tcgaaatggt agtaaggaat cataacggga accgtttccc aacgtccgct catcgcgtca
       61 tagtatcgct gtactcccat ttccatccca aagcggtcgg acatatcgac ggacatcgta
      121 gctccgtagc tatgggtact catcccgtaa gaatttccga tatcgtatga accgaagacc
      181 ttgaaggtga catggtcgga aggatgataa aggaaggcgc ccgaagtgct gaaagcctgt
      241 ccggtgatat gggacatgtt gactttcagc gcattggcac ggacttgtaa ctcgaattgc
      301 tcattgaaaa tgtgctgata acctagtgaa gcactgttga aacgaccgat gcctgccata
      361 cttgtctggc ttccggaacc gaacagtgct ccatgatcga attgatgcaa taccccgccc
      421 gtgctgtaat cacctcggaa gagtagggaa ggattggtct gataaggtag ggaaatatcc
      481 cttttgagtg aaaagcgggg tatatgctcc aactgtccgg gtgaatataa agaatatgta
      541 gtgctctttt ctggaaacaa gttaatgttg gcctgtttaa gtacgtcgtc cggcgttatg
      601 gatgcaccgt tacgaagtat gtgcgtgctg tcgttgtttt cttgcgcgga gagtaactgc
      661 ggaacaaaat acagcaaaag aaagattccc aaacgaattg gaagccgtga tatgctaact
      721 ttttgtctca tacgcatttg ccctccttag tttttatgat aggttatgta caaaaataat
      781 gaaatcccat ttgaaaagca aataatgtgt aatgtttcct tccatccgca ggctttttta
      841 actcaaataa gagcagataa gattttttct gaataaattc ccttttttcc cttaaattct
      901 tctctctctc aggcaatatt cgttgtatat ttgttattat agatataaga gtatcaacta
      961 tttaatttgg aaggaatatg aagaaaaaac ttacgggtgt tgcattggtg ttagctgccg
     1021 tctctttgat gggcatacag ccggcggaag catgtacgcg tgccgtatat ctgggaccgg
     1081 acggaatggt ggtcactggt cgcacgatgg actggaaaga agacattatg tcaaatatct
     1141 atgtgtttcc acgtggaatg cagcgtgcgg gacacaataa agaaaaaaca gtaaactgga
     1201 cttccaaata tggaagcgta attgcaacag gctatgatat aggtacttgt gacggaatga
     1261 atgaaaaagg actggtggca agcttgctct tcttgccgga atctgtttat tcacttcccg
     1321 gagatacccg tccggcaatg ggaatcagta tctggactca atatgtgctt gacaattttg
     1381 caacggtgcg tgaggcggta gatgaaatga aaaaagagac tttccgtatt gacgctcccc
     1441 gtatgccgaa cgggggaccg gaatctactt tgcacatggc tattaccgat gaaacaggca
     1501 acacggcagt gattgaatat ctggatggca aactgagtat ccatgagggg aaagaatatc
     1561 aggtgatgac caattctccg cgttatgaat tgcagttggc tgtcaatgat tactggaaag
     1621 aagtgggtgg attgcagatg ttgccgggaa cgaaccgttc gagcgaccgt tttgtccgtg
     1681 cctctttcta cattcacgcc attccgcaga ctgccgatgc aaagatagct gtccccagtg
     1741 tgctgagtgt gatgcgcaat gtctccgttc cgtttggtat caatacaccg gagaagcctc
     1801 acatttcttc tactcgctgg cgttccgttt ccgatcagaa gaataaagtg tattactttg
     1861 agtctacttt aactccgaac ctgttttggc tggatttgaa gaagattgat tttagtccga
     1921 aggctggggt gaagaaactg tccttgacca aaggagaaat ttacgcagga gatgccgtga
     1981 aggatttgaa ggatagtcaa tcatttactt tccttttcga aactccggtg atgtagtcga
     2041 tagttagtta tgtggtaaga ggtctttttt tgaataaaaa ggaacggtag gcaaaggatt
     2101 tatccgcttg tctaccgttc ttcttttatc ttcgtgtcct gcgtgcggct ataggcagcc
     2161 tttatctttt cgcatattcc tgatggaact caatcactgc ctctattcct ttccggaata
     2221 tgtccagcga gaagttttcg ttgggtgaat ggatcgcatc cgattcaagt ccgaagccca
     2281 tcaatacggt tttggttcct aatacctgtt cgaatgtcga aatgatagga atacttccgc
     2341 cacgacgtac tgccagcggt tttttgccga aagctatctc aaaacctttt tccgcagcct
     2401 gataggcagg aagggaaatc gggcagacat atccctgtcc tccgtgcatt ggggttactt
     2461 ttacctgtac ggtgtcggga gccatttgta agatataatc tgcaaacatc tgcgaaatct
     2521 tgtgatgatc ctgatgcgca accagtcggc aggaaacttt cgcatacgct ttcgagggaa
     2581 ggactgtctt ggagccttca cctgtatatc ctccccaaat gccgcataca tcgaaagacg
     2641 ggcggcaact gttgcgttcc agtgtgctgt atcccttttc tccgaagagt tctttcactc
     2701 cgatggcttc tttgtatttc ttctcatcga acggaatatg ggcgatcatt tcccgttctg
     2761 cttgcggtac ttcttctacg tcatcgtaga atccgggggc ggtgattctt ccgtctttat
     2821 ctgttacttt gctgattatt tcgcaaagca cattgatcgg attagctacc gcacctccga
     2881 agtgtcccga atgcaggtca cggttcggtc cggtcacttc tatttcccag taagccagtc
     2941 cgcgcagacc ggtggtgagg gatggaagtt cggcacccag catgctggta tccgaaacca
     3001 ggataacgtc tgctttcaac agctctttat gctcttcgca gaaggcttcc aggctgggag
     3061 agccgatttc ctcttctcct tcgaagataa acttgacgtt atttttcagc agttcgttct
     3121 tgacgagata ttcgaaggct ttgacctgga taaaggattg tcctttgtca tcatccgctc
     3181 cgcgtgccca gatgtatccg tcccgtactt cgggttcgaa gggctggctt ttccacagtt
     3241 ccagcggttc ggcaggcatt acgtcgtagt gggcgtagac caatactgtt ttggcattcg
     3301 ggtcaacgat cttttgtgcg aaaacaatcg ggttaccctt ggaaggcatc accaatgctt
     3361 catccactcc ggcttcgagc agtagttgtg cccagcgttg ggcgcaagcc agcatatcgt
     3421 cgtgatgttc cggcagggcg ctgatactgg gaatacggat gaggctgaac aggtcctcca
     3481 taatcttcgg ttcgttcgct gcgatatatt tttgaatttc gttcataatg aatagtttac
     3541 tggcggttat ttagcctatg tgccaatagc ctgacagatt tttagtgcag gtattggcac
     3601 atgggtagat tgacatattg atacttatta aagctgcgtt gtcttatcca acagataata
     3661 atcaaggata gtcatggcag ccattgcttc tacgataggc acggcacgtg gcagtacaca
     3721 ggcgtcatga cgtccgcggg ctttcaatgt cgtatctacg ccgtcgatgt tcaccgtttc
     3781 ctgctccatc agcagggtag caatcggttt gaatactaca cggaagtaaa tatcctgtcc
     3841 gttactgatt cctccctgaa tacctccgga gtggttggta tgtgtttcaa tccgtccgtt
     3901 gttgttgaag aatacgtcgt tctgctcgga gcctttcatc ttcagtccct tgaatccttc
     3961 tccatattcg aaggctttgg cggcattgat actgagcatg gcgttgccca aggcagcgtg
     4021 cagcttgccg aatacgggtt gccccaatcc gataggacat cctttgatga cacaggtcag
     4081 cgtacctccg atggtatcgc cttcgccttt taccttatat ataaggtctg ccatttcctt
     4141 cgccttttcc gggtccggac agcgtacgtc gtttgtttcg atcaggtcga gatcatagtc
     4201 ggaataagtg ccttccaatt tgatggcacc gacttgcgat gtataagctg tgatgctgat
     4261 tcctaactgg cgaagggcta atttagccaa tgcgccggct actacgcgtg aaatagtctc
     4321 gcgggcagaa gaacgtccgc cgccgcgatg atcacggatg ccgtacttca ctttgtaggt
     4381 gtaatccgcg tgtgaagggc ggtatacctc tttcaggtta ttgtagtcat tggaatgttg
     4441 attctcgttc caaacgataa atccgatagg acatccggtt gatttgcctt cgaagatgcc
     4501 tgaaagaaac tccactttat ccgcttcctt gcgtggtgtg gtgaggatgg attgtcccgg
     4561 acggcgtcga tttagttctt gttgtacaaa ttcttcgtcg attgtgattc cggaaggaaa
     4621 tccgtcaatt actcccccaa ctccttttcc atgagactcg ccgaaactgg tgagtcgaaa
     4681 gatgttgcca aatgaattaa acatagttgt ggctttttta aaattactct atgcaaatat
     4741 aacaaagttt tcgataagaa ggttgtgaat tcaaaatatc ttcggaaaag gaagcaaatt
     4801 gaaccttttt tcctcttttt agtttataaa tgacgattat ttaataacta aacccgaaaa
     4861 ttatgaaaaa gaatctattg tatttgtggg cattgatatg ctctgtctct cttttgacgg
     4921 cttgtagcag tgatgacgat aatacggtca atgatgaaac gactcctccg gaagaagaag
     4981 ctgtggtgac tgctcccgac gtggtgggaa cgtattgggg aaatctcgat atttcaatgc
     5041 tgcccgatgg ctccgaccag gaagttgtga ttgccgacgg acttccgaag tttattactt
     5101 tctctcaggt cagcgatacg gaagtaaaga tggaactgaa ggaatttgaa ctgtttataa
     5161 acggaaacat attaaagttc ggcgatatcg tgatagacaa gtgtgcggtg aaaaaggaaa
     5221 cggatgcttc gactttcacc ggacagcaag accttacttt tcaaggagat gctgccgctc
     5281 tgggtacctg tgccaccagt atagaaggaa cggtacaagg cggaaatgct acgatgaata
     5341 ttcaggtaaa agtgcctgca ttgcagcaga ctgtgaaagt tgctttctcc ggcgtgaagc
     5401 aggtggagga atccggtaag gattaatccg tctttgctta gctagaaagc atatccgaat
     5461 ccgatattca agtagatcgg atacatagca aaagtaatgg tctgaaagtc atttctgaag
     5521 atatcattca atccccaagt gaggtctgca tatatattga gatgtttgaa tgctctccat
     5581 ccggctccta tttgcaggcc ccactgaaaa tgtctcaggt cgtccgagaa gtcataagta
     5641 gcgattttac catccgtaaa ttctactttg ggacctacgg ggtcgccttc gcgcaggtat
     5701 ccttcatata cgtgccccga aaattctctt gaaagcagat atgaaaaata aggtccggct
     5761 ttaatattcc aacggttgct caacttgtaa gtagccatta gaggaattgt cagtccggaa
     5821 gtgtggactt tggttttgac tcctcctgtc cagacaccgc tgattctttc tcctccctgt
     5881 ccgaggattt ccatattata gtttttgacg gtggcttccg ttgtcatggc tttattctcc
     5941 agccgcagcc ctacaatgac tccgagcttg ttttgaacgg caaaccattt ggttacttct
     6001 cctccgatgc tgatagccag cgttgggttg tagccgtcaa tcgaacggat ttcgacaggc
     6061 agcgggagcg gggctgtacc gccgatgctg acccctgctt tgatttcata ttccagtccg
     6121 tgaagagcgg agcgaataag tgtttcgttt ctgtcaacct gtgaatagcc ggggagggct
     6181 atcaccagac aggcgagtaa actgaatata taggaatgga ttttcatctt ttcattatta
     6241 ttaaatcatt agttatttca ttatagttgc tctgttctgc cttccatagc tgctatcaga
     6301 tcgttggtcg aatggaatca gtcttccgag cgatagatta gttcgacttc atcaatcaac
     6361 aatgtacttc cgatagctcc gttaaaatga tctccttcca ggctggaagt gaatacgata
     6421 gctacattat actttcctgc tgttagcttc tctttatcta tgtattttcc ggataacata
     6481 tgaaagggaa gtttaaagta tgtccactcg tccgtctctt tggcgtcgtc aatgcgtgct
     6541 attgaaacca ggttgggact ggtgaaagca ttcgttccgt caagagtcgg cacagattca
     6601 ctggtttcat acatgatggc ataaatatcg catatatccc gtttgccact gacgggtttg
     6661 ccgccttctg taaactgatc tccggcttta tacttgtaat agcctgccag ataagttggt
     6721 atatgccgga aaggcagacc gaatttggtc tctttcagtg gattgctcat tgcatttcct
     6781 acatcaaaag agccgataaa caggttcccg gctgcgatag gcattcccat aatgctaccg
     6841 aagaatccgg tactgcgggt tactaaggac aggcattttc cggtttttcc gtttgcaaac
     6901 tgaaaagtcg gatagtcgtc ggctgtcttg ggaactccgg tcattgcata acctgcgttt
     6961 ccgctggccc attccatcac cactttttct ccttcccgtt ctacgaagat gtagtatttc
     7021 tgtccaccga gcgtatcctc aaaattgtaa atagtagcaa gttccgtatc aataacggat
     7081 acggtgtact tcttcttcca aaagccatcg gcagccgtaa cggtatattg ctgaggcgaa
     7141 tggaaatctc tagccgtccc actgggagga tcgatagtgg ctcccggagt caatgtaaat
     7201 tcgggtgcaa gggatgaaat gtccgttccc ggtcctacaa atatattgat ggaattatta
     7261 gtgataatcg gactcgttgt catgactact cccggcaatc tgcaactgag tatgtctgcc
     7321 tctgcattgg gagcttcttc gcgaatgcaa gaagaagaga aaatggctag cagcaaataa
     7381 agaataccgt gttttgcttt catttttcta ctattctaac tgttaaagtt cggttcttgg
     7441 aagattttat aacaatctgc aattttattt gttcactaat ggatgtttga taaaaaagaa
     7501 ttttctactt ttgtggaaac taaagcctta tagggtatga ttgaatcgga aagaaaacag
     7561 ataatagact tgatcaaaaa agaggtgatt ccggcgatag ggtgtacgga acccattgcg
     7621 gtagcgcttt gtgtagctaa agctgccgaa acattaggaa tgaaaccgga aaagattgaa
     7681 gtgttattga gtgccaatat attaaagaat gcaatgggag tcggtatccc cggcacagat
     7741 atggtcggac ttcctatagc tgtagccttg ggagcgttga tcggccgatc ggaatatcaa
     7801 ttggaagtgt tgagagactg cacaccggag gcagtagaac aaggcaaact gtttatcgca
     7861 gagaagcgaa tctgtatttc tctcaaagaa gatattacgg aaaaactgta catcgaagta
     7921 atctgcacag ccggcagcca aaaagcgacg gctgtgattg ccggcggaca tactaccttt
     7981 gtctatatag ctacggatga aaaagtactg cttgacaagc aacagactgc caatgaagag
     8041 gaagaagacg cttcactgga actgaatctg cgcaaagtct atgattttgc cctgacatcc
     8101 cctctggatg aaatccgttt tattctcgat acggcacgtc tgaacaaagc agccgccgag
     8161 caagccttta aaggcaatta tgggcattct ttaggtaaga tgctccgtgg aacgtatgaa
     8221 cataaagtga tgggtgacag cgtattctct catatactat cttatacttc cgccgcttgc
     8281 gacgccagaa tggctggtgc aatgattccc gtcatgagta actccggcag tggcaatcag
     8341 ggcatatccg ccacacttcc cgttgtcgta tttgccgaag aaaatggtaa aaccgaagag
     8401 gaactgatcc gcgccttaat gctgagtcat ctcactgtaa tctatattaa acaaagtttg
     8461 ggacgtctct ctgccttgtg tggctgtgta gtagctgcca cgggttccag ttgcggaatc
     8521 acctggctga tgggtggaaa ctataatcag gtagcctttg ccgttcaaaa catgattgcc
     8581 aacctgacgg gaatgatttg cgacggtgca aaaccgagct gcgcactcaa agtaacaacc
     8641 ggagtctcaa cagccgtatt atctgctatg atggcaatgg aggaccgttg tgtgacttct
     8701 gtagaaggca ttattgacga agatgtcgat caaagcattc gtaacttgac aagaatcggc
     8761 tcgcaggcca tgaacgaaac ggataagatg gtgcttgata tcatgacgca caaaggagga
     8821 tgttaacagg taataagtaa caagtaataa gtaatagctg gaataacggc ataaaaaaag
     8881 tattaagtat taacttccgc ctatatccgc atggaattaa tacttaatac ttattaccta
     8941 ttacttaaaa ttagtggcag tgtccgcctt cgcaaccgca gtcatcgcca cagtcgctgc
     9001 cgcagctgtc gcatccgcaa ccgcaacctt caccgctcat catcttcacc agttcctgaa
     9061 tttcttcgtt ggtagcagga cggctttcga ttacttcacc ttcaaagatc aggtcagcgc
     9121 ctgccaatgg gtggttaagg tcaactacta ctacatccgg tttgatttct acgacgctgg
     9181 cgtttacgcg ttgaccgtct ccggtcatca aaggtacaat gctgccttct gttacgcgtt
     9241 cgctgtcgaa cttgccatct atttcaaaga tatttttagg aagatcaaat acatgttgct
     9301 catcgtaggc tccgtaagct tcatctgccg gaatggtaaa atcgaattta tcacccttgg
     9361 aaagagctgt tatctggttc tcgaagcttt cgagcgttgt gcctaatcct gaaatgaact
     9421 gaaaaggatg ttctgcattt gtttcttcga acaattcttt ttcaccatct tccactgtat
     9481 atagcttata tgcaacggtg atgtacttgt tttctactgt ttccatctga tatttatagt
     9541 ttctaattaa taaatccctt atttagggtg gacaaagata cgaataattt gcttgctacc
     9601 gggtgcatac ggagtaaatt tcagattatt aagcgctttt gtcagaaatg gacagtcatt
     9661 ctctactaac tgatagttgc aaattcaacc tttaagtgat aaaatttagg tttattaccg
     9721 ttcttttctt acgattattc gctttttagt gatttttttc ttcgatttgt ttggagataa
     9781 taaaaaagcc cttacctttg cagcacgaaa ataaagaaaa gaagatatga atatattaca
     9841 tacatctatt aacctagcag ttctgcatat tattcgcgtc gtggtggtgc catcaagagc
     9901 gtgagaaagg ttttgtgtat gtattcgtac cataaaagat agaatttgga gcctttctca
     9961 ctgatgtgag ggaggctctt taattaaaag atagattgaa atgaaaaagc aattacgcag
    10021 ttcgtttagt acacaaggcc gtcgcatggc gggagcccgc gcattatggg cagccaacgg
    10081 catgaagaaa aatcagatgg gaaaacccat tatcgctatc gtcaattcgt ttacacaatt
    10141 tgttccggga cacgtgcacc tgcatgaaat cgggcagttg gtgaaggcgg aaattgagaa
    10201 gctgggatgc ttcgctgcgg aatttaatac gattgctatt gatgacggta tcgctatggg
    10261 acatgacgga atgctttact cgcttccttc ccgtgatatc atagcggaca gcgtagaata
    10321 tatggtcaat gcgcacaagg cggatgcaat ggtatgtatc agcaactgcg ataagattac
    10381 cccagggatg ctgatggcgg ccatgcgcct gaatatccct accgtatttg tatccggcgg
    10441 accgatggaa gccggagagt ggaacggtca gcatctggac ttgatcgatg ccatgattaa
    10501 atcggcggac gacagtgtaa gcgatcagga agtagcgaat atcgaacaga atgcctgtcc
    10561 tacctgcgga tgttgttccg gaatgtttac ggcaaactcg atgaactgtc tgaatgaagc
    10621 tatcggcttg gctcttccgg gaaacggcac aatcgtggct acgcacgaaa atcgtacgaa
    10681 actgtttgaa gatgctgcca aactgattgt ggaaaatgca atgaaatatt atgaagaagg
    10741 tgacgaaagt gtacttcccc gcagcatagc tacccgtcag gcattcctca atgccatgac
    10801 gctggatatt gcgatgggcg gttctaccaa tacggtgctt cacctgttgg ccgtggcaca
    10861 tgaggcagga gtcgatttca agatggacga catcgatatg ctgtcacgca agacaccctg
    10921 cctgtgtaaa gtcgctccga atactcaaaa atatcatatt caggacgtta accgtgcggg
    10981 tggcatcatt gctatcctgg cagagttggc aaaaggcggt ctgattgata cttccgttct
    11041 ccgtgtggat ggcatgtcgc tggcggaagc gatcgatcaa tattcaatta ccagcccgaa
    11101 cgttacggaa aaagcaatga gcaaatattc aagtgcggca ggaaacagat tcaatctcgt
    11161 acttggttct cagggagctt attatcagga attagataaa gatcgcgcga acggatgtat
    11221 ccgtgatctg gagcacgcct atagcaagga cggaggcctg gcggtactga aaggaaatat
    11281 cgctcaggac ggttgcgtag taaaaacggc gggtgtagac gaaagcatct ggaagtttac
    11341 cggacctgcc aaagtattcg actcacaaga agcagcctgt gaaggcatcc tcggaggccg
    11401 agtcgtcagc ggcgacgttg tcgtcatcac gcacgaaggt ccgaagggcg gtcccggtat
    11461 gcaggaaatg ctttacccga cttcttatat caaatcccgt cacctcggca aagaatgtgc
    11521 cttgattacc gacggacgtt tcagtggtgg aacttccgga ttgagtatcg gacacgtttc
    11581 tcccgaagcc gctgccggag gtaatatagg aaaaatagta gatggagata tcatcgaaat
    11641 cgacattccc gcccgaacga ttaacgtgcg actaacagat gaagaactgg ctgcccgccc
    11701 gatgactccc gtcacccgtg accgttacgt gccgaagagc ctgaaagcat acgccagcat
    11761 ggtaagctct gccgataagg gagcagtgag attaatagac tgatccactt cattatccat
    11821 tatgaatcat ccattatcca ttaaagaact atgagtaagg acttaataac aggcgcagag
    11881 gcaatgatgc gctctctgga acatcaggga gtgactacca ttttcggtta tcccggcggg
    11941 tccatcatgc ctacgttcga tgccctgtac gaccatcaaa atacattgaa ccatatcttg
    12001 gttcgccatg aacagggagc tgcccatgcg gcacaaggct acgcccgtgt atcgggtaaa
    12061 gtcggtgttt gcttggtgac aagcggcccc ggagcaacca atacgatcac aggtattgca
    12121 gatgcaatga tagacagtac gcctatcgtt gtcattgcag gacaggtggg aacaggcttt
    12181 cttggaacag acgcttttca ggaagtcgat ctcgtaggta tcactcagcc aatcgctaaa
    12241 tggagctatc agattcgccg tgccgaagac gtagcctggg cgatagcacg tgctttctac
    12301 attgccagta gtggtcgtcc cggtccggtg gtactcgact ttgccaagaa tgcgcaggtt
    12361 gaaaaaacga aatacgagcc gacaaagcag gagtttatcc gcagctatgt tccggttccc
    12421 gatacagacg aagaatcggt aaaggctgcc gccgaactga tcaataacgc cgaacgcccg
    12481 cttgtcttgg taggacaggg agtggaactg ggaagcgctc aggaagaact gcgtatcttt
    12541 atcgaaaagg cggatatgcc cgcaggttgt accttgctcg gactttccgc attgcctacc
    12601 gatcatccgt tgaataaagg aatgctgggt atgcacggaa atctgggacc gaatatcaat
    12661 accaataaat gcgatgtgct gattgctgta ggtatgcgtt ttgacgaccg tgtgaccggt
    12721 aatttggcta cttatgccaa acaggcaaaa gtgattcatt ttgatatcga tcctgcggaa
    12781 gttaataaga atgtaaaggt agatgtagct gtattgggag attgcaagga aacactggct
    12841 tctgtgacga aacttctgaa aaagaacact cataccgaat ggattgatag cttcaaagaa
    12901 tatgagaaag tagaggagga aaaagtaatc cgtcctgaac ttcatcctgc cacaaactct
    12961 ttgagtatgg gggaagtggt acgtgcggta agcaatgcca ctcaacatga agcagttttg
    13021 gtaacagatg taggtcaaaa tcagatgata tctgcacgtt acttcaaata tacgaaagaa
    13081 cgcagtatca tcacttccgg aggacttgga actatgggct tcggtcttcc cgcagctatc
    13141 ggggcaactt ttggagcacc ggaacgtacc gtatgcgtat ttatgggaga tggtggactg
    13201 caaatgaata ttcaggagtt gggtacgatt atggagcaga aagctccggt gaaaattatc
    13261 tgcctgaata ataattacct cggaaacgta cgccagtggc aagctatgtt cttcaatcgc
    13321 cgctattcgt ttactccgat gttgaatccg gattatatga aggttgcttc ggcttatgat
    13381 attccttcca aacgtgcttt cacccgtgaa gaactgaaag aagctattgc agaaatgctg
    13441 gcgacagatg gtccgttcct gctcgaagcg tgcgtagtgg aagaaggcaa tgttttgcca
    13501 atgactcctc cgggtggttc ggtcaatcag atgctgttgg aatgctagga gaagttgaat
    13561 attgagaatg gaagattgaa agttcgcaat taaaatttag gattatgagt gacaagacat
    13621 tatatacgat aatagttcat tccgaaaata tagccggatt gctgaatcag gtaactgctg
    13681 tatttactcg tcggcaaatc aacatcgaga gtctgaatgt atctgcttct tctattaaag
    13741 gtgtacacaa gtatacgatt acagctttga cggataagga caccattgag aaggtagtga
    13801 aacagatcga aaagaagatc gatgtgattc aggcacatta tttcaccgag gatgaaatat
    13861 acttccatga gattgcacta tataaggtat ctactcctgc ttttcaggaa actccggaag
    13921 catccaagct gattcgtaga tacaatgcac gtatagtgga agtcaatccg gtattttcta
    13981 ttgtcgagaa aaatggaatg agcgaagata taacttcgct ctatggtgaa ctgaaggctt
    14041 tgaattgtgt tttgcagttt gttcgttcgg gacgtgtagc gattactacc agctgctttg
    14101 aacgggtgaa tgagtttctc gatggacggg aagctatgta taaccaaagt aagaaccaat
    14161 aagaataatg agtgaagaaa atagaatagg gacttatcag tttgtggcag aaccgttcca
    14221 tgttgacttc aacggacgtc tgactatggg ggtactggga aatcatctgc tgaattgtgc
    14281 aggttttcac gccaatgacc gtggttttgg tattgcaacg ctgaatgagg acaattatac
    14341 atgggtgctt tcacgtctgg ctattgagtt ggatgaaatg ccttatcagt atgagaattt
    14401 ctcggttcag acatgggtgg aaaatgtcta ccgtttgttt acggaccgta attttgc
//
