LOCUS       c00031_gnlPro..        16374 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JNOFGKJD_31.
ACCESSION   c00031_gnlPro..
VERSION     c00031_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:38:52
            Original ID  :: gnl|Prokka|JNOFGKJD_31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16374
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16374
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2822:6374](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2823..6374
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16374
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16374
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(249..1376)
                     /locus_tag="ctg31_1"
                     /transl_table=11
                     /translation="MAPASARQMASELALLPMWYAEEGSVVLAPSAYNLDYVKKIQELL
                     GLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLDLGVEESELPSIEQLDKLRFCSHRS
                     CAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESHDTCLLKAPLSGSGKGLNWCKGVYT
                     PSISGWCSRIGKQQGGVIGEPLYNKVEDFAMEFRSSSNGRFGFAGYSQFRTGGSGAYEG
                     NLLISDAAIERNLLEYIPVEEIYKLRDRLEQELSLRFGTIYNGYLGVDMMICRFPESPV
                     YRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAFQISYYPTEGTAWRAHKEMEEAYPL
                     EIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL"
     CDS             1612..2790
                     /locus_tag="ctg31_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2823..6374
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_3"
                     /sec_met_domain="PFOR_II (E-value: 1.3e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.5e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.5e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.1e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 8.2e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.1e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.5e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6527..7393)
                     /locus_tag="ctg31_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7414..8238)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg31_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.5e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8235..9461)
                     /locus_tag="ctg31_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9761..10099)
                     /locus_tag="ctg31_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10183..11478
                     /locus_tag="ctg31_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11618..14458)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 63; E-value: 1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg31_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 3.7e-20, bitscore:
                     63.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKVMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDQLIQLSH
                     QLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQRRMLLLVQRNVNILL
                     RLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAVARKKHIHFSFDYMPDTDYR
                     TLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIRFTVANTGSMISAEH
                     IRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQGTIFTVDLPVQTCET
                     VVSENSPAFSVSATSVTSTDATTSAVAGVPATPATSGYSGSSSLNDALTYEEEELEKSY
                     DSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPG
                     MDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVR
                     NLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGL
                     SRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCY
                     REQFGESPTDLLKRKG"
ORIGIN
        1 tatcttaaat gacaacttat acaggaatta caaagggaca agtaaactta tttaggtttt
       61 aaaaaatatt gagtaaacta acttaggtat aacaagcgaa gttgtcaact aaatccagta
      121 cagtacacac atggcatgtg attacttgtt tcatgcaatg aaactttttg tttctcggtg
      181 tggaaccaat ggtttcacta catgaaacta tcagtttcac accgagaaac cataacttcg
      241 atataatatc acaaaaacac gctttttgag ataaacaccc acgcccgata actactcttt
      301 ttatgagccg gcaccaatga caaatagcct gattttattc ttccttgttc tatttccaaa
      361 ggataagcct cctccatttc tttgtgtgct ctccaggctg ttccttccgt agggtaatag
      421 cttatttgaa aagctcctgt tgaagtagga tagatataat ggtcataaat atgacgcgct
      481 actactccca tattcatcct caagttgatt tccacgcaag gatgaatccg ataaacagga
      541 gattctggaa agcgacagat catcatatcc actcccaaat aaccattata aatggttccg
      601 aaacggaggg ataattcttg ttcaaggcgg tcgcgcaatt tataaatttc ttcgacaggg
      661 atatattcca aaagattccg ttcgatggct gcatctgaaa tcagcagatt accttcgtac
      721 gccccacttc cacccgtacg gaattgagag tatccggcaa agccaaatcg accattactc
      781 gaagaacgaa attccatagc aaaatcttcc accttattat atagaggttc gccaataaca
      841 cctccttgct gtttgccaat gcgtgagcac caaccggaaa tagaaggagt atatacacct
      901 ttgcaccagt tcagcccttt cccgctaccg gataaaggag ctttcagtaa acaagtatca
      961 tgtgattcta caaatgactt ccattcttcg ggaaacgtca ggtaaaaaga ctctccacaa
     1021 aaacaggctc ccagttgtag ctgtggtaat aatcccacag cgcaggaacg atgggaacaa
     1081 aaacgcagtt tatccaattg ctcaatagaa ggaagctcgc tttcttccac tcccaaatcc
     1141 aacagtcgtt ttcttattgc tatatcccag ccccaaggac gaatatccaa attccgctcc
     1201 gaagcaagtt caggttctgt catcaaatca accgaaagtc ctaataattc ctgtatcttc
     1261 ttcacatagt cgagattata agcggaagga gccaatacaa cacttccctc ttctgcatac
     1321 cacatcggca acaaagccaa ttcggatgcc atctgccggg cggaagccgg tgccatatag
     1381 tttgtttcac cgctggctaa cgccaaatca tgttccggat tgaatatata aagagccttt
     1441 tttgtcattt taaacgaatt caaaacttta ttctgcaaat atatacagga aatagtcagg
     1501 aatggctaca ataaacagaa agttctaatt aaactcacaa ttttgccatc tctactttgc
     1561 aaatcctaaa aaaaagcagt atatttgcca cccgaaaaac aaagaactga aatggaatca
     1621 ttctatcgca cacacgccta cctcgttgag cacaccaatg cccccgttcg ccgcgatctt
     1681 atggacgaga tcgactggag cgaccgcctg attggtatca aagggacacg tggcgtagga
     1741 aaaaccactt tccttctcca atacgccaaa gaaaaatttg ggaacgaccg ctcctgcctg
     1801 ttcatcaaca tgaacaactt ctacttctct ggccacagca ttgtagactt tgctaacgaa
     1861 tttcagaaac gtggcggaaa agtattgttg atcgaccagg tgttcaaaca tccggaatgg
     1921 agcaaagagt tacgcatgtg ttacgaccgt tttcctaacc tgaaaattgt cttcaccggc
     1981 tcgtccgtga tgcgactgaa agaagaaaat cttgaattac gtgatatcgc caagagctat
     2041 aacctgcgcg gattttcttt tcgcgaatac ctgaacttac agacaggcat gaaattcagg
     2101 gcatacagcc tcgaagaaat tcttagcact cacgaacaga ttgccaaagg agtactctct
     2161 aaagttcgtc cgctggatta cttccaggat tacctgcatc atgggttcta tccgttcttc
     2221 ctcgagaagc gtaacttctc ggagaatttg ctgaaaacga tgaacatgat ggtggaagta
     2281 gatatacttc tcatcaaaca aattgaactg aaatatcttt caaagataaa aaaattacta
     2341 tatttgctcg ctgtcgacgg gccgaaagct ccaaatgtga gccaactggc aagcgacata
     2401 cagacatctc gcgccacggt gatgaactat atcaagtatc tggcagatgc gcgactcatt
     2461 aatctggttt atccgaaagg ggaagaattc cctaaaaaac cttcgaagat aatgatgcac
     2521 aactccaacc tgatgtattc catctacccg gtgaaagtgg aggagcagga tgtgctcgac
     2581 actttctttg tgaattcttt atggaaagac cataaggtac ataaaggaga taaaaacgtc
     2641 tcttttatgg tggacgaagt aatgccgttc aaaatttgcc aggaaggagc aaagatcaag
     2701 aacaatccga atgtgacgta cgcgttgcat aaggctgaaa taggtcgggg caaccagata
     2761 cctctctgga tgttcggctt tttatattaa aagatttatt tacttaaata tttaatttag
     2821 ttatgactaa acagaagaaa ttcatcactt gtgatggtaa ccaggctgca gcgcatatct
     2881 cgtatatgtt ctctgaagta gctgctatct accccatcac tccttcttcg actatggctg
     2941 agtacgtaga cgaatgggct gccgcaggac gtaagaacat cttcggcgaa acagtattgg
     3001 tacaggaaat gcaatctgaa ggtggtgctg ccggtgcagt tcacggttct cttcaggctg
     3061 gtgcgttgac tactacttac actgcttctc agggtcttct cctgatgatc cctaacatgt
     3121 acaaaattgc cggtgagttc ttgccttgcg tattccatgt atctgctcgt acattggctt
     3181 ctcacgcatt gtgtatcttc ggtgaccacc aagacgtaat gtcagctcgt cagactggct
     3241 ttgcgatgtt ggctgaaggc tctgtacagg aagttatgga tttggctggt gttgctcact
     3301 tggctactat caaatctcgt gttccgttca tgaacttctt cgatggtttc cgtacatctc
     3361 acgaaatcca gaagattgaa atgttggaaa atgatgatct tgctccgctg attgatcagg
     3421 aagctttggc tgaattccgt gcccgcgcac tgaatccgat gaatccggtt gctcgtggta
     3481 tggctgaaaa tcctgaccat ttcttccaac atcgtgaatc atgcaacaac tactatgaag
     3541 cagttcctgc tatcgtagaa gaatacatga atgaaatttc taagattaca ggtcgtaaat
     3601 acggtttgtt cgattattat ggtgcagaag atgcagaacg cgtaattatc gctatgggtt
     3661 ctgtaacaga agctgcccgc gaagctatcg accacttggt agcaaatggc gaaaaagtgg
     3721 gtatggttgc cgtacacctg tatcgtccgt tctctgctaa acacttcctg gctgctgtac
     3781 ctaagactgc caagactatc gcagttcttg accgtactaa agaaccgggc gctaacggcg
     3841 aacctcttta ccttgacgtt aaagactgct tctacggcgc agaaaatgct ccggttatcg
     3901 ttggcggtcg ctacggtttg ggttcaaaag atactactcc tgctcaaatt ctttcagtat
     3961 tcgagaactt ggccatgcca atgccgaaga atcacttcac tatcggtatc gtagacgacg
     4021 ttactttcac ttctcttcct caaaaagaag aaatcgcttt aggcggtgaa ggaatgttcg
     4081 aagctaaatt ctacggtttg ggtgctgacg gtacagtagg tgctaacaag aactctgtaa
     4141 agattatcgg tgacaacact gacaaacact gccaggctta cttctcttat gactctaaga
     4201 agtcaggtgg tttcacttgt tctcacttgc gtttcggtga tactccgatc cgttccactt
     4261 atttggtaaa tactccgaac ttcgttgctt gtcacgttca ggcttacctg cacatgtacg
     4321 atgtaactcg tggtttgcgt aagaacggtt ctttcttgct gaacactatc tgggaaggtg
     4381 aagaactggc taagaacctg cctaacaagg ttaagaaata ttttgcacag aacaacattt
     4441 ccgtatacta tatcaacgca acacagattg cattggaaat tggtttgggt aatcgtacca
     4501 acactatcct tcaatctgca ttcttccgta tcacaggtgt tattcctgta gaccaggctg
     4561 ttgaacagat gaagaaattc atcgttaagt cttacggtaa gaagggtgaa gacgttgtta
     4621 acaagaacta tgctgccgtt gaccgtggtg gtgaatacaa gactttagct gttgatcctg
     4681 cttgggctaa cctgccggat gatgcaaaag ctgaaaacaa cgatcctgca ttcatcaacg
     4741 aagtagttcg tccgatcaat gcacaagatg gtgacttgct gcctgtatct gcattcaagg
     4801 gtatcgaaga cggtacttgg tatcaaggta cttctaaata cgaaaaacgt ggtgtagccg
     4861 cattcgttcc tgaatggaat ccagaaaact gtatccagtg taacaagtgt gcatacgttt
     4921 gtcctcacgc ttctatccgt ccgttcgtac tcgatgctga agagcagaag ggtgctaagt
     4981 tcgaacaatt gaaagcagta ggtaaagtat tcgacggtat gacattccgt atccaggttg
     5041 acgttctcga ctgtctgggt tgcggtaact gtgctgacat ctgtccgggt aatccgaaga
     5101 agggtggcaa agcattgaca atgaaacacc tcgaaagcca attggctgaa gctgacaact
     5161 ggacttactg tgctgaaaac gtgaagacta aacaacatct tgttgatatc aagtctaacg
     5221 tgaagaactc acagttcgct actccgttgt ttgagttctc tggtgcttgc tctggttgtg
     5281 gtgaaactcc gtatgtgaaa ttgatttctc aattgttcgg tgaccgtgaa atggttgcta
     5341 acgctaccgg atgttcttct atctactctg gttcagttcc ttctactccg tatactacga
     5401 acgaaaacgg tcacggtcct gcttgggcta actcactgtt cgaagacttc tgtgaattcg
     5461 gtttgggtat ggaattggct aatgaaaaga tgcgtgctcg tatcgtgaag ttattcaacg
     5521 aaatccttgc tgccgacaac gcttcacctg aagcaaaaga agtgctgaaa gcatggattg
     5581 aaaacatgta cgatgctgac aagactaaag aattggctcc tcaagtgaaa gcagtgattg
     5641 aagaaggtct ttctcacgga tgtcctattt gcaaagaact gaaaggactg actcaatatc
     5701 ttgtaaaacg cagccaatgg atcattggtg gtgacggtgc ttcttacgat atcggttatg
     5761 gtggtcttga ccatgtaatc gcttccggta aggacgttaa catcctcgtt ctggatactg
     5821 aagtttactc taacacaggt ggtcagtctt ctaaggctac tccggtaggt gctatcgcta
     5881 agttcgctgc tgctggtaag cgcgtacgta agaaagacct cggtctgatg gctactactt
     5941 acggttatgt atatgttgca cagatcgcta tgggtgctga ccaagctcaa actctgaaag
     6001 ctatccgtga agctgaagca tatccgggac catctttgat tatcgcttac gctccatgta
     6061 tcaaccacgg tctgaaagca ggtatgggta agagccagga agaagaagaa aaagctgtta
     6121 agtgcggtta ctggcacttg tggcgttaca acccagcttt ggaagaagaa ggcaagaacc
     6181 cattccaatt ggatagcaaa gaaccgaact gggaagattt ccaaggtttc ttgaagggtg
     6241 aagttcgtta cgcttctgta atgaaacaat atcctactga agctgaagaa ctgtttaaag
     6301 ctgctgaaga aaacgctaaa tggcgttaca acagctacaa acgtttggct agagaaaact
     6361 ggggtgctga ataatagtaa taccctataa atataaagcg gtaatcttat caaagattac
     6421 cgctttttta ttgtatgaac tctgtccaac ataaacagta ctcccttttt cccactagag
     6481 ttcatgtcta ttttatattt aaaattaaga ataacaatgc tccaatctat ttattctctg
     6541 acttcggaat ccaactatcc accaacagcc gatgctcatc cctccattta cgggctattt
     6601 cttcttcatc catcctggca tccttcatag ctgtcataaa agagctaagt tcttctgtcg
     6661 ttagtttgat gttgccaaag aattcggcag caaacggatc tttctcactg aatcctttcc
     6721 atgcaatagc atgtatttct tccaagtctc catatacttt cttcggatca tccaagaatt
     6781 tcaagtcaaa ctggtcgaac atccaatgcg gtgtccaccc cgtaatgaca atccattctc
     6841 ctttgtccat cgcttttttc aaagaagcca gcatggtgga actacttgaa gtcatgaggg
     6901 tatacccatc aagtccgtaa gcagcaatgg ccttatcggt cgtcttcatt atccctgctc
     6961 ccgcatcaat tcctactatt tcagaggaaa aacggtcttt attagcttcc agctcattaa
     7021 tagagtggat cgtaacatat tgaggaacaa ccagtccgac gcgagcttct ccgtatacct
     7081 ccccaaaaaa ttcgatgctg tctccatact gatccatata atctttcatc gttattggta
     7141 accatgcatc cagaaacaca tctgatttct ttcctgacat agatacaaaa ataggggcaa
     7201 gatcagcatt ttgcaattca acctcatatc catgctcttc caataccacc ttagccaaat
     7261 gactcatggc aataccttcc agccaattgg cataggctat ttttactttc tttttctcta
     7321 agtctgaatt agtacaggaa gctagcaaaa gcatagctga caatactatt cctactattt
     7381 tatatattct catacgtatt ttatcctttc cgtttagttc ttattttttc gtcctgccat
     7441 tccttgcgtg atacggtcta agatgatagc taaaataaca actgctatac caccttcaaa
     7501 cccaagtccg attttcattt gggtaatacc tttcaataca atttctccca gaccaccggc
     7561 agcaatcatg gcagcaatta caaccataga aagcgacatc attattgtct ggttgacacc
     7621 agtcagaatg gtgggcaacg ccaaaggaag ctgcacttta tacaataact gccaacgggt
     7681 agctccgaac gaacgggaag cttccactac atttttagga acttgccgga ttcccaatcc
     7741 ggtaaggcgg accacaggag gcatagcaaa gataatggtg gcaaacactc ctggcactgc
     7801 tcccaatccg aaaaacaaaa cagcaggaat cagataaaca aaagcaggca tcgtctgcat
     7861 caagtcgaga acaggacgga gtattttctc tgcacgcgaa ctgtttgccg tccatactcc
     7921 taaaggtaca ccaacaatca gggccagaca ggtagatgaa aaaacgagag ctagagtttg
     7981 catggtagcc tcccagaatc ccattccata gatcagtaat aatcccaatg cggtgaaaat
     8041 tgccgtaccg cgtcctgctt tcatccatgc gagtgcagca agtaccaaaa tggttatata
     8101 aaaaggtatt ccgaaaagta tgtgttggaa tcctataata aaactaccga tgcccgcatt
     8161 cacggcatca aagaaagtgg aaaaatgtat catcatccaa ttgatggcca tctctatata
     8221 ttgtcctata tttatcataa atctattgcg ttttgaatta tttcgtttat ttcttcttta
     8281 tctttcccgg tcacttcgat gattaaggat gaaagcggga ttgttcctaa aaactcgcgc
     8341 gtctcatcaa tcacccatac cggcgaattg ctctttgtca ttagaggaag tatatcctcc
     8401 aacaccgtat cctccaacac agaatgtact tctgtacgca caatcgtttc aatggatttt
     8461 tcctgtttgc tacgtaactt aagcaagtcg ttcagacgta cttctccgac cagtttatca
     8521 tcggcgtcta tgacaggtaa tacggtgata ttcttcgcac gcatcttacg aatcaatact
     8581 tcgggacctt ctttcttcag acgggccacc aacggtttgt caatcattaa agaagaggcg
     8641 gtaataattt tgctcctatc cacgttttca acaaaacggg ctacataatc gttagccggt
     8701 tcagtcagga tttcctccga agtacctacc tgcaccactt ctccgtcttt catgatggca
     8761 atacggtcac ctagcttaat tgcttcactc aagtcgtggg taataaaaac aatcgtcttt
     8821 ttcatctttg attgcaaggc cagtagttca tcctgcatct gtacgcgaat cagaggatcg
     8881 agagcagaga aagcctcatc cattaaaagc acttcaggat tattagccag agcgcgagcc
     8941 agtccgacac gctgttgcat tccaccggaa agctcgccta ccatctgatt ttcatatcct
     9001 ttcaatccga caagcttcat gctttccatc gctttcttct cacgttcctc tttcttcact
     9061 ccctgaagtt cgaggccgaa cgcgatattg ctcaatacgg aacggtgagg taacagaccg
     9121 aaattctgga aaaccatcgc cagctctttc cgacgaacct gcaataattc tttttcggaa
     9181 attttagata tatctactcc gtttacaagc acttgcccgg tagtaggacg tatcagacga
     9241 ttgatacaac gcagtaatgt cgattttcca cttcccgaga gtcccattat cacgaaaaac
     9301 tctccttcat taattgaaag attggcatct ttcactccta ccgtacaacc ggtatctttc
     9361 agaatttcct ctttactctt atcttttttc aacatcttga gggctttctg cttctcgtta
     9421 ccaaagataa ggtacaaatc ctttatttct attttactca tataatatat tggtttagat
     9481 tataatattt gttttgtttt caactgccgc attccttatt ctcacttacg ataaacaagt
     9541 tgaatgttcg catggttcag tcatgtcaca tgataacatg acggtccgac gttttttaaa
     9601 tggttaaaaa aaaacagaca gagtagttta aaaggaatag aatttgataa gattatcctc
     9661 ttaatgaaca gtagaaaaca gtattttcat aaataaataa cagtctgttc ttgcatattg
     9721 ttggcacaaa ggtaaggaaa atagattaaa tatgcaaatt tcattcaggt acggagtaat
     9781 tccaaagatg ctttttcaag tctacgcatc cattttgttt gaaagagatc ccttcttcca
     9841 acaagagttg tttctgctct gtccaacccg gaacaagccg tcccgacgca ttgacaaccc
     9901 gatgacaagg cgcagataaa tcatccggaa tctgtttcaa agcacgcccc accatacggg
     9961 aacattgaga cattcccaat aatgctgcaa ttcccccata ggtagaaact ttacctaccg
    10021 gaatttctcg gacaacctga tacacctctt gacaaaagga tgcggaaagg ctcgccttat
    10081 ctactttata atctttcatc actcaaacat tactttattt cagttccaaa actagataaa
    10141 aagaaaagaa tttgcaaata ataaaagcat ttcaaataaa atatgcaact ttatttgctt
    10201 tatttacaaa taatcccgac ctttgtaccc attaaaagca accctattat taacaaaaca
    10261 agcactgctg ttatgaaaaa gaaaactatc ctgttcgctt cttgtttatt gggagcactg
    10321 gctttcagct cctgtgagaa gaacctttat gatgaaagta aacaacccga gaaagaaaag
    10381 aagatgactg acttggaagt acctgccgat ttcgactgga aaggttctca aaatgccaaa
    10441 gtgaaaattg ccagtcaatc aactgctact atttctgtat ttctagaaga aaattgcaat
    10501 gaagaggctt tgatgcttcg aatggatgtc gatgccaaca catcaaaatt ggaactccca
    10561 attgaaattc ctgcatatat aaaaaatgtg tatgtaaaat atggtaatgg ctctgaaata
    10621 caaactgttc ctgttgaaag taatggtact atttctatag tagtacctgc taacgctacg
    10681 gcattatcca gagttaccac aagagctaat aaagaagttg aaacgaacaa catcttcaat
    10741 tatccgggat atggcaacgg aactattatg ttcgaagata tgtatccagc tttaggcgat
    10801 tatgatttta atgattttgt tgcatggtat aatttccaaa ttgacggttt ttattggagt
    10861 cacaatcaat gttatgcaga atacttaatg ataggattcc aaatcagagc tataggaggt
    10921 atatatgact acaatcctta tatccgcttg gcagaagtac aatataatga acttgattta
    10981 gaagaaactc aaatgtatct tgagcgtaac aatcctgaag aggctgaaaa tatcaaaatc
    11041 ctaaaaggcc caaaagggga attgattatt tcactaaaga aaccggccat tcctaacgga
    11101 tacaagtatt ataatacgga ggtaaatgaa aaaacaaagc ctaaaaaaat gatggccatt
    11161 tacttggtgt tcaactcacc tgttaacgtt aaaagcctac aagacagtaa aatggacttt
    11221 tatattgcaa aaactaataa aggacaagaa atccacttaa aaggttatag cccggtttat
    11281 tataacagca acgaaagtta tgtaaatgaa gacaacttta tatggggatt aaaagtacct
    11341 gcatctttac atcatgccag agaagaagta aacttcttgg aagcatatcc agactttgaa
    11401 caatgggtaa catcgggagg tcaagagaac caaagatggt ggaataagcc aaaaacgaat
    11461 aagttgatta tgaattaata aatatacagt aaatcatata ctgaattaaa taagaggtaa
    11521 ggtatgtcaa tagatttcct tacctcttat ttttatcata tgaattctag aagtataaac
    11581 agataaatgc tcaccaccaa attttgcaga ttctatccta tcctttcctc ttcaacaaat
    11641 ctgtcggact ctctccaaac tgttctctat aacatttagt aaaataagaa ggagaactaa
    11701 aaccaacttc ataacctatc tctgccactg tcatatccga cgaagcaagc agggaagcag
    11761 ctttcttcaa acgagctata cgaagcagtt cattcgggga ataattagtt agggatttga
    11821 ttttgcgata gagttgcaca cggcttaatc ccatatcttt acccaagtct tccacattca
    11881 aatttgaatc tcccatcttt gcctcaatca aagctttgaa tttttccaca aagtctttat
    11941 ccatatcaca gacatcctct ttcgccaacg tttgtccgtc accaaaaaac tgtttcaggc
    12001 ggcggtgtga atctatcaga ttacgaacgc gtgccaatag taattgcgaa ctgaaaggct
    12061 tggagatata agaatctgca ccaccatcat acccttgaat tcgttgttca tccaaagaac
    12121 aagctgtcaa taggataaca ggaatatgac aggtttgtaa ttcgcttttc aagcgacgac
    12181 aacattcaat tccatccatt ccgggcatca ttacatcgga gataatcaag tccgggacat
    12241 atttcatagc tttacgaata ccttccgagc cgtctgcagc ttctataaca gtataatcag
    12301 tatgaagcaa tccatgcaca tataagcgaa tatcagcgtt atcatcaata atcagaacgc
    12361 aaggtttgga agagtcgtaa cttttttcca attcctcttc ttcgtaagtt aaagcatcat
    12421 tcaagctcga agaaccggaa taaccggaag ttgcaggagt tgccggaacc ccagcaacgg
    12481 cagaggttgt agcatcggtg gaggttacag aagtagcaga cacagagaat gccggagagt
    12541 tttcagaaac aacagtctcg caagtctgca caggcaaatc aacggtaaag atagttcctt
    12601 gcttttcatc actttccacc gtgatggtac ctttatgcaa ttccacaaaa gcctttacca
    12661 atgccagtcc aatacccgaa ccggcatggt gcatatctat cttatagaaa cggtcgaaaa
    12721 tattccggat atgctccgca gaaatcattg aaccggtatt ggcaacggta aagcgaatcc
    12781 agcaatgatc gtctttagtc agggaagaca agcgtacagt tacttttccg ttttccggag
    12841 taaatttgaa agcgttggaa aggaggttga aatagatgcg ttccaacttt tctacatctg
    12901 ccaatgtgcg gtaatccgta tccggcatat aatcgaatga gaaatgaata tgcttcttcc
    12961 gggctactgc catgaaagat tcgttccatc cttcaaaaga agaaagaatg tctaacgaaa
    13021 taggagtata ttccattttt ccattctcgt atttacgaaa atccagaatc tgattgacaa
    13081 gacgcaaaag gatattcacg tttcgctgaa ctaacaataa cattcggcgc tgatcttcac
    13141 tcaaagacga atcagccagt aaatgctcta ccgggtcggc aactaatgtc agtggagtac
    13201 gaaaatcgtg agatatattt gtgaagaaaa ccagcttggc atgagtcgct tcttccagtt
    13261 gatgagaaag ctggataagc tgatcccgtt gctcttcgag tttatcgcgc tgttgctcta
    13321 cttgtttctt ctgttcggac aactctttat tcaggcgatt cttggaacgg agggatttat
    13381 agactaccaa caacaatccc gctactaata aaagaataac caagccgcca tacatcacga
    13441 cctgctgcgt agctacacgc gacagatacc caccgatacg tccgttcaat gtttcaatct
    13501 tctgatccag ttccgagata tgggtagtct gaagttgcat aacgtgcgcg ttcgtgcggt
    13561 ctacaacggc agtattcatg accgtttcgc gaggataaga cttcttctca agaatattca
    13621 tggccagttg catcactttg tccccattag tcggataaat aaaagttgca tccagcacat
    13681 tgtcaagcac caattcaagc ccgtttcctt tgccgggcag ggcatcaatg ccaacaaaaa
    13741 tcattacctt ttcacgtccg gctttcttcg cagcttgata ggctcccgga gcgatacggt
    13801 cgttatgtgc atataccgca tcaatcttcg gatgacggcg aagcatacta tccatttcca
    13861 cttctgccgg ttcacgttcc caggcagcat ccgctttatc aatcagtttg atatccggat
    13921 aattgctgat agcagccata aatccctgat ggcgttccat ggcaggggtg gaaccaccca
    13981 gtccggtaag ctccactaca ttccctttcc ctttcagact tgatgcgata taatttccta
    14041 ccgcacgacc tatttcataa ttatcggcac cgatataggc agtatattta tcagaaagta
    14101 tcttccggtc tacaagaatg acaggtattc ctttctgata ggcctcctcc acaattggag
    14161 tcatgggagc cgcttcattg gcggaaatta tcagtaaatc aactccttta tctataaaat
    14221 aatgaacatc ttccgcctgc ttacggttat catccgccgc cgagcggatt tcaaccgaca
    14281 ctccatcata aaacatcgct tcgcgaagaa tctcatcatt catcttgtgc ctccaagagt
    14341 catcgctaca ttgggccacc ccaatacgga aacgaggcgc atcctgccga caggccgcca
    14401 agcccaaaag acaaaacaag actgttatcc acttcgtata tttcatcgct tcaatcattc
    14461 cctttctttc gtatatcttt tgtatttctt tctgtaatcc aaatttctct ccccgcatta
    14521 tttgcattca ccaccgggaa atacatcagt tccactttca cagggttcag cgtatatttt
    14581 ccagtaaagc gtggaagcaa aggaaccgta aactgataag tacctaccgg taatttttcg
    14641 ctaaagataa cagttttctc tttaaaatac tcacgatata cttcagaacg ggagaaatta
    14701 acaggttttg aggcataact acaacctgcc ggaacaggaa cttcgagcat cacatattgc
    14761 gcaccctcct gtttcacctg caaggtaact gtcaatgtaa caggtacacc cgccaccaaa
    14821 gagtcttttt ccaaagtcac ctccaccttg aaagcatcac tctgacgagc attcatcaca
    14881 cgcttcattg aatagacact atacaataaa ggctcttttc ccgtttttga aataagcaga
    14941 ctgtcgcttg ctgtcagccg ggcatgataa ggaaattccg taattcgttg atgatcctta
    15001 ccgctcacag acaccgacgt tcctgacatc cctccggaac ctgccagcaa atcggtcaga
    15061 acagttgcca cagccgaaga agcctgatac gtattccatc cgcgctcctt agtccgcaaa
    15121 atatacaatt gcatattttc tttcaactta cacagggaag ggtcattttt aataatccgg
    15181 taggctatca atgtatttat catctgattt ccctcccaat aataagtacg ccgtccgtcg
    15241 tcacagtaaa caccttccag catatccttt ttcagataag gacgtacgct atcacccaca
    15301 ttcaccgaat ccacctgttg cttgatttcc cagagaagca gcttctcttt caagtatgaa
    15361 agaggacgat aatacttgtt tctatttgcc aacgagtctt ctttctgttc caattgccgg
    15421 acgaaaggtt ccaataatct gactgccgaa gaataatccg cctctacttt ccactcatgc
    15481 agagcatgaa gtatttctat atcttccagt ttcattcctc gataaggacg cgtatgagca
    15541 tactccactt tcaaaccatt cagattcaac tccacaggat aacctgcatc ttgcgccatc
    15601 ttcaaagccc gcagaatatg cgcagacatc cagaaagaag tattttcaga gttcccccac
    15661 cacgaccata actgatgttt gttctgatga ttcgtcagtc gatggatgat aggtcgaatt
    15721 gctttatcta ctttcacctt ttcaccctta ctctgcatat actgttggta agccaacaaa
    15781 ccgattaact tggatgccag ctgctcattg cacaaatatt tgtatcctgt caagtaattc
    15841 actgattctt tatagatgtc caactgattg tcagtgatac tcaccatcac ttcttcatcc
    15901 tcgccggatt gcactttaac cgtctttgca tcggacagaa tacccaatgt gccctccgcc
    15961 aattcagttc cctgtgccag tatcggaatc gtatattcct ctccatcctg atagccatcg
    16021 tcgcgagtga aaagatagct gatggtcacg ctatcggcat gaactgcctg catcggcact
    16081 gtttcatgaa atccctccat gaaactcact tcctgccgtt tcaacgtatc cgttccgacg
    16141 cagaactgtg tctttccggc tatgtgctgc ccatccagat aattgcggat agtcccgacc
    16201 accgtactct gatccccctc caccaagaag cggggagttt tcaactccgc catcaacggt
    16261 ttgtaagagc ggacgaaacg tcggaaagta cccgtctgca aacgacggtt catgccataa
    16321 acgacagttt cccatttcgt cacattatcg gggaaagttg tttcaaactg tacc
//
