LOCUS       gnlProkkaDJLGNHJO_81   14314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DJLGNHJO_81.
ACCESSION   gnlProkkaDJLGNHJO_81
VERSION     gnlProkkaDJLGNHJO_81
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:46:02
            Original ID  :: gnl|Prokka|DJLGNHJO_81
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 835
            Orig. end    :: 15149
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14314
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14314
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14314
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             394..972
                     /locus_tag="ctg81_2"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPRERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSAPLARGEKVRVIKGPLTGLVGELVHVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             983..1351
                     /locus_tag="ctg81_3"
                     /transl_table=11
                     /translation="MDAVILQENIEGLLNLVRMLLPGGGSAGCVYLDDLSALQRSIHKQ
                     INDLYSQRGKTPEQDATLCLAILQGYNVSMYANSEDEDRKRSVLQRSLTLLDVLPPSLL
                     KQQLSAVCHGMQELCETN"
     CDS             1367..3778
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg81_4"
                     /sec_met_domain="Poly_export (E-value: 1.4e-18, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCSMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSQSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3789..4937
                     /locus_tag="ctg81_5"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_6"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.8e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_7"
                     /sec_met_domain="CTP_transf_like (E-value: 2.6e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.1e-121, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             7059..8183
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.4;
                     E-value: 1.2e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_8"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.4e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-21, bitscore:
                     65.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIARGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8193..9314
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 1.6e-33.
                     Score: 107.9. Matches aSDomain:
                     nrpspksdomains_ctg81_9_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 75.5; E-value:
                     6.4e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_9"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-30, bitscore:
                     96.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLLVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKVSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8283..9290
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg81_9_Aminotran_5.1"
                     /evalue="1.60E-33"
                     /label="ctg81_9_Aminotran_5.1"
                     /locus_tag="ctg81_9"
                     /protein_end="366"
                     /protein_start="30"
                     /score="107.9"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLLVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKVSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9311..9784
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_10"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             9781..11226
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_11"
                     /sec_met_domain="Polysacc_synt (E-value: 1.1e-32, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             11226..11948
                     /locus_tag="ctg81_12"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             11962..12975
                     /locus_tag="ctg81_13"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             12980..13939
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_14"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.3e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 gtgaaccgga tgaatttgtc ttacgtaaag cggtgcggag taggtcagtg tatctgattt
       61 agaagcttga tatacagtgt ttatcggtgt gcgttacttc ttaggtaacg gaatgattca
      121 tggcgcaaag atggacatat ttatgaaaat acgcaaacaa aaatgaaatt aatttcggaa
      181 aatgaatcaa atgcaggcat aacaggcgga aaatgacaat atccgtgtta tgtctttttt
      241 ttattccaat tcatgaaaaa caccttcact tctgccttat ttcctgaata ccagtcctct
      301 tccgatgttt tcgttgaaaa aagttccctg tttcgcttgt cctttgtttg tgagttacct
      361 aagaagtaac ggataaacat ggggtaaaaa aacatgattt taagaaaaaa gaaatcactc
      421 aatgctgggc ctattaatgg gacaggggaa ggcgtagcac actcaaaacg ctggtatgtt
      481 gctttggttc ggatgcatca tgaaaagaag gtttccgagc atctggacaa gatgggtatc
      541 gagaatttcg ttcccgttca acaggagttc caccaatgga gcgaccgtcg caagctggtc
      601 acctccgtct tgcttcctat gatggtcttc gtacacgttg accctaggga acgcatggaa
      661 gtcctgagtt tttctactgt gagccgttac atggtgatgc gcggcgagag tagtcctgct
      721 gtaattcctg acgagcagat ggcccgtttc cgtttcatgc ttgattattc tgaagaatcg
      781 atcagcatga acagtgcccc tttggcccgt ggcgaaaagg tccgcgtgat taaaggcccc
      841 ctgacgggtc ttgttggcga actggttcat gtggatggca agagtaagat cgccgttcgc
      901 ctgaatatgc tgggatgtgc ctgtgtggat atgcctgtcg gttatgtaga gcctattatg
      961 gcggctgttt aaggcgaggg atatggatgc tgttatttta caggaaaaca tagagggttt
     1021 attaaatttg gtacgcatgc tgcttcctgg tggggggagt gcaggctgcg tgtatctgga
     1081 tgacctttcc gccttacaac gatccatcca caaacagata aacgatttat attcacaacg
     1141 ggggaagaca ccggaacagg atgctaccct gtgtttggcc atccttcagg gatataatgt
     1201 gtcgatgtac gccaattcgg aagacgagga tagaaaacgg tctgtcttgc agcgttctct
     1261 gaccctcctt gatgttcttc ccccttctct tcttaaacaa cagttgtctg cggtctgtca
     1321 cggtatgcag gaactgtgtg aaaccaacta acttttttat ttgtcaatga aaatacaacg
     1381 actttttagc attctacttt tttgttctat gctgggaagt ggctcgctta tggcccagtc
     1441 catgagtgac tcacaggtac tggaatatgt gaaggacggc atccggcaag gcaaggaaca
     1501 gaagcagctt gcttccgaac ttgcgcgtaa aggtgtgacc aaggaacagg ctatgcgtgt
     1561 gaagcagctc tatgagcagc agaacaatgt aaacacctcc caatccacgg gcacggacat
     1621 caacgaatcc cgcctgcgtg aagagactaa gaagaatact tccgatatgc tggaggatca
     1681 tccgactact caggaccttg cccgtggtga tcaggtcttc ggacgtaaca tcttcaatac
     1741 ccgcaacctg acgttcgagc ctagtgtcaa ccttgccact cctgccaatt accgtcttgg
     1801 tcccggtgat gaagtcatca ttgatatctg gggtgcgagc cagaacacga tccgccagca
     1861 aatctctcct gaaggtacta tcaacattca gaagatcggc cctgtcaacc ttagcggtat
     1921 gacagtctct gccgccaatg actatctgaa gaacgccctg aataaaatat ataacggtct
     1981 gaataatact accgatccta cttccgacat ccgtctgacg ttaggtaata tccgtactat
     2041 tcagattaat gtgatgggag aagtcgtaca gcccggtacc tacgcccttt cttccttctc
     2101 taccgtcttc catgcgcttt atcgtgcagg cggtgtgagt gatatcggta gcctccgaaa
     2161 cgttcagttg gtacgcaacg gaaagaatat tgccaccatc gacgtctacg aattcattat
     2221 gaaaggcaac acacaggatg acatccgcct acaggaaggt gacgttgtga ttgttcctgc
     2281 ctatgatgta ttggtaaaga ttagcggcaa ggtaaaacgt cctatgcgtt ttgaaatgaa
     2341 gaaagacgag aaccttgcta ctctcattaa atatgccggc ggctttgaag ctgatgccta
     2401 cacccgttca ttacgtgttg tccgtcagaa tggtgaggaa tacgaagtca acacagtcaa
     2461 agatatagat tacaacattt ataaaatgcg taacggtgac gtagtaaccg ccgaagccat
     2521 ccttaaccgc ttcacaaaca aactggaaat ccgtggcgct gtctatcgtc ccggtatcta
     2581 ccagctcagc ggtaaactga acacgatccg cgaacttgtc catgaagctc agggtctgac
     2641 cggtgacgct ttcctgaatc gtgccgtcct ctatcgccag cgtgaagacc tgaccagtga
     2701 agttgttcag atagacatta agtctatcat ggacggcact tccccaaacc ttgccctaat
     2761 gaagaatgac atcctctaca ttccaagtat ccatgacctg gaagaccggg gtaatgtcac
     2821 agttcacggt gaggttgccc accctgattc ctatccttat gcggataaca tgacacttga
     2881 ggatctgatc attcaggccg gtggcttgaa agaagccgcc tctactgtcc gtattgatat
     2941 atcgagacga atcaagaatc ctcgtagtac tgcggataat gatacgattg gtcagatgta
     3001 taccttctct ttaaaggatg gttttgtaat agatggtcag cccggtttta tccttgagcc
     3061 ttatgatcag gtttatgtcc gtcgcagtcc gggctatcag gcacaacaga atgtagccat
     3121 tgaaggtgaa atccttttcg gaggaaatta cgccatgacc agccgtgagg aacgtctttc
     3181 cgatttagtg aataaagccg gcggtccgac caattatgcc tatctgcgtg gtgcgaaact
     3241 gacccgtgtg gctaacgcta gtgaaaagaa acgtatgggt gatgtaattc gccttatgag
     3301 caggcaattg ggcgaagcca tgattgactc tttgggtatt cgtgttgaag atacttttac
     3361 ggttggaata gatttggaaa aagccttgag caatcctaaa agtaatgccg atcttgtctt
     3421 acgtgaaggt gatgtgatct ccatacctaa gaatactaat actgtaacta tcaatggtgc
     3481 tgtcatggtt ccgaatacgg tttcttatat gaagggaaag aatgtggatt attacctgaa
     3541 tcaggccggt ggctgttctg ataatgcaag gaagagtaag aagttcattg tttacatgaa
     3601 tggtcaggtg acgaaggtta agggtagtgg taagaaacag attgagccgg ggtgtgagat
     3661 tattgtgcct ggtaaggcta agaagaaagg gaacatagct aatattttag gttatgctac
     3721 ttccttcagt tctttgggaa tgatgattgc ttctattgct aatttgataa agaaataaat
     3781 gacctattat gattgaaaag caatcttatc aagaaccgtt ttctgaagtg gataaaagga
     3841 aagatgatga aatggaaata gacttgatgg ctatttttta taagattatt actgttcgtg
     3901 gagtactatg caaagctgct ggagtgggag taataattgc tatagtggtg gcattgagca
     3961 ttcccaagca atatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggaa
     4021 gtaatggttt agccggactt gctgcctcgt ttttgggaga tggggctcta ataggggaaa
     4081 gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat
     4141 tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt
     4201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     4261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     4321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgctttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttatatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtgg cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaatagct ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca acccccgatg tacgtttaaa
     6181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     6241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     6301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga
     6361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     6421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     6481 cactttagaa cgtcatggaa tctcagctat aataattgaa gataaagttg gattaaaaaa
     6541 gaattcattg tttggtacgg atgttattca aactcaagat acaatcgaag gtttctgtaa
     6601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     6661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     6721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     6781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     6841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     6901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agacaatatt
     6961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaagg aaatattgga
     7021 actgattccg ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     7081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     7141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     7201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     7261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     7321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     7381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     7441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     7501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     7561 tttttggcaa atataaactt caaaaagaat tcggatgtaa ttatccttta tctcgtgagg
     7621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     7681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     7741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     7801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     7861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     7921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     7981 ctattgcccg ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg
     8041 aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta
     8101 agatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc
     8161 attttatgga ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa atattattaa
     8221 atcctgggcc tgccactact actgacagtg taaaaatggc acaagttgtt ccggatattt
     8281 gtcctcgcga gaaagaattc gcaggtatga tgaaacaact tcgggacgat ttggtcagag
     8341 ttgctcatgg gaatttggaa aaacatacag ctgtattatt ttgtggctca ggaactatca
     8401 atattgatat atgtctaaat tctcttcttc ctgaagacaa aagggtgctt atagtgaata
     8461 atggggcata tagtacccgt gctgtagaag tgtgtcaata ttatggtttg cctcatatta
     8521 atttggaatt ttctgtttat gaacgtcctg atttattggt agtggaaaat gtgttacaag
     8581 aaaatcctga tatagctatg gtttatacta ctcatcacga gacgggtaca ggaattctga
     8641 accctattcg cgagatgggc gctatagctc ataaatatca ggctaaattt gtcgtcgata
     8701 ctacttcttc tttgggcatg attccttttg atatagagaa agataatgta gatttttgta
     8761 tggcatctgc tcaaaaagga cttcaagcga tgacaggtct ttcttttatt ataggcaatg
     8821 aggaacagat taaggtttca aaaaaatatc ccaagcgttc ttactattgt aatctttatt
     8881 tgcagtatga gaattttgag agaacaggtg aaatgcattt tactccaccg gtacaaacta
     8941 tttacgccac tcgtcaggca ttaaatgaat attttgaagt gggcgaagaa gctaagtttg
     9001 cccgtcacaa aagagttttt gaggctattc attcaggtat aaatgaaatt ggtcttaaaa
     9061 gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc agttcaatac ccagaagatc
     9121 ccaactggga ttttgagaaa atacatgatt attgttatga gcgtggattt acgatttatc
     9181 caggtaagat atcaactgag gatactttta gaatctgtgc tttaggagag atagaagtag
     9241 atgatattga gaacttcttt aaagtactaa aagctgcatt aaatcattat aacgtcacat
     9301 taccgatgtc atgattgcag aaatattatt gaagattcgt catttttatt tttcccttcg
     9361 tggtatacac ttccatccgg aaagtgttat ttctggagtg cctattcgta gctttcgctt
     9421 agtaggcaaa tatagcaata tctacttggg taaaaatgct gaaatacgtt caggctgtta
     9481 tctgattgct cgtgataaaa tcattattgg agaaaactca acactcgcct atggaacgac
     9541 tatattgaca actgctgatc ctaatggacc gtataatgca ttagcagttc tttatcctta
     9601 taaaaaggca ccggtagtta taggagataa tgtttggatt ggggctaatg ttaccatcct
     9661 tcctggagta actattggtg attacgttgt agtagcagct ggagctgttg taacaaaaga
     9721 tgtaccttca ggagtattgg tagctggtgt accagctatt gtgaaaaaac gttttaataa
     9781 atgaaagaaa aaacttcttt aaagaacaaa gccatatgtg gaatcttttg gagtgcagtt
     9841 gaacgatttt tatcacaggg gatacagttt gtagttacag tcattatggc gcgttttcta
     9901 ttgccatctg attatggaat ggtaggaatg ttagcaatag ttcttcaatt atctcaaacg
     9961 ttaatggata gtggttttac taatgccctt attcgttata aggaacgtac tgaaattgat
    10021 tattcaacag ttttcttttt taatatatta gcatcattag ttatttattt tctaattttt
    10081 tttctagctc cttatatatc gtggttttat aaaataggtc aattagttga gattactaga
    10141 attttatcta ttgttattgt tttaaattcc tttgcgatta ttcctaaaac taaattaata
    10201 atagctgtag attttaaaac tcaatcaaaa gtctcattta ttgcagcttt ggtttcaggt
    10261 attattggca tttgggctgc atatttagat tttggagttt gggctttagt tggacaaact
    10321 ttagtaaacg gattgttgat tgtagttttg tatgcatatt tttgtagatg gaaaccattg
    10381 tggatatttt cattgaaatc gtttcgttta ttatttgctt ttgggtcaaa attagtatta
    10441 gctaatattc ttaatacttt atataaaaat ctgtatgcta tagttatagg aaagaagttt
    10501 tcgtcggttg atttaggatt ttatactcgt gcggaacaat ttgctcagtt tccttcatat
    10561 aatttgagtg caataatttc tagagtgaca taccccatat tgagccttgt gcaaaatgat
    10621 aatgatagat tatctgcttt atataggaaa tatgtccgtt tatcttctgc ttttatcttt
    10681 ccattgatga ttttgttaat tgtcatagct cagccactgg tattattgct tttgacagaa
    10741 aaatggatag gagtagttgt attgcttcaa atattgtgtt tagattggat gtttgatcat
    10801 ttgagtagta taaatttgaa tttactatat gtaaagggac gttcagactt ggctttacgt
    10861 ttagaagtta taaaaaaagt gttagcgacg gggatccttc ttctatctat tccttggggg
    10921 attgtaggta tgtgttgggg gcgtgttatg tattcattga ttgctgtgta tttgaatact
    10981 tattatacag aatcattgat taaattaagt cttattagac agatgagaga tatactacca
    11041 agcttttttt tagcattaat aatgggagga ggtacttggt atatgatttt attgttagag
    11101 ggtgaaattg ttcaaattgt agtaggaagt gttattgctt tattgctata tggaacgttg
    11161 ttgtattgct tttctcgatc cttgtttgat gaaatatggg cggttatatt aaaaataaaa
    11221 aggtaatgga taaactgagt ttgattatta gtaaaatacg acggaatcat tggtatagaa
    11281 cctatatgcg tcctatatat ttatttgttt atggcaatag aaaattgaag aatagaaata
    11341 gaatattttt gcagtattca caagagctgc taactaactt tcatcaagca atgaatgaag
    11401 tgggaattcc ttattggtta gaatttggaa ctcttttagg tgctgttaga gaacacagtt
    11461 ttataagtca tgattttgat cttgatgtgg gcctttttaa ggaagattat tcagatataa
    11521 taagagaggt cttaaaaaaa tatggtttca aaagaataag gtgtataacc gcccttgatt
    11581 ttattgatgc ttatgaggaa acttatcttt ataaaggtgt gacaattgat cttttccttt
    11641 tttcaagaga gaaaaattgt gatggggtct attgttatga ttttgttcca gtatattcag
    11701 atataaagag aactaaaaaa ggtgataatg caatccggag aattcatttt cctagaattg
    11761 atttgattga atattcattt attggaatta atacttttgt tcctgaaaat tatgaggaac
    11821 atctttgtat gcattatggt aaagactata tgattccaaa tcctcattgg aaagattcag
    11881 atgcgcaaca tactgatatc ttttatggta gagagattag aattgaattg tttgataaaa
    11941 gtaaataata gtagataata catgttctat ctattttttt tactaattgt gctatttttg
    12001 ttatatatac aaagtaggaa aagacaatat tctactgtag cgggaatttg tgttcctatt
    12061 attataattt ttgttgtaat ttgtcgttat agagtggggt atgactattt aacgtattat
    12121 acattaattg aaaatgaaga agaggcacag attttatact tattttctcc tttaagcatt
    12181 gtttgggcag agattgcttt atattttgaa tctccacaga tgttatttgt tctttttggg
    12241 cttccaacat ttgctcttct aatatttact ttaaaaaaat attcaaaaga ttatgcgtta
    12301 tcagtaacta ttttaatttg tttcttcttt tttacatcac tcagtattat tcgacaagct
    12361 ttggctttgg ctatttgttt ttatggttat cgttttatag taaaacgttc actaattaaa
    12421 tatatattat gtatattgat tgcagcttta ttccatcctt ctgcaggagt agcgattatt
    12481 atatattggt tgccatttct aaagtttaga ttagttgtat tattatctat aatatcaata
    12541 gtagccaaac ctttattttt ttatatgcta aatatattag gggtgtatac ctcttatctt
    12601 gatggcaaga tggatattga aggtgggaaa tatactcaat taatatactt tttgttgttt
    12661 attatttgtt ttgttttggg aagtaaaaac atagataaaa acaagtgtaa tttatttaat
    12721 gttttattgt taagttttgt tttcgtatct tttttaggag ctcatttagg cgggagaata
    12781 gcgttttatt ttaatatata ttattgtttg ttgattccta aagtggttaa aggattggat
    12841 gggcaactaa gagagcaagt gaagcttctt tcttattttc tatgtatttc ttatttctta
    12901 ttgtacctat tcgttccatt cataaaaggt gtaccctcat attatatccc atataagttt
    12961 atatttttca aatagtaaaa tgttgatatc tataattgtc ccttgttata attctgaaag
    13021 atatttgtct gattgtttat tgtctatatt gaatcaaacc tatgttaatt gggaggtgat
    13081 ttgtatagat gatggaagtc aagataatac attatctatt ttaaatcatt acgctacatt
    13141 ggatgagcgt tttaaaatta tttctcagtc taatgcagga gtgtctgtcg caagaaataa
    13201 ggctctatcc cagtgtcaag gagagtatat ttgctttgtt gatagtgatg acctgataga
    13261 acctaatttt ttgataacac ttttacagct tataagtcat caggctgatt tggcaatctg
    13321 tggttttact cgttctatgg ttttctgtat ggatgatgct caaggatata tagaaatgag
    13381 tggtaaacgt tgtatagaaa gaattattct agataaaagt ttcaatcctc agatttgttg
    13441 tatgttattt cgacataata ttataaaaga gaaacaatta gaatttgtga tagggtgtac
    13501 tcgtggtgaa gatcgtgaat ttatattgaa atatttagtt tattctaata aggtttgtta
    13561 tacaaacaat cttctttatc actatcgtgt aaatgatcag tcagccatgg caatcttttc
    13621 tattaaaagt ttgacaagta tagaagcttc acaacgcacg gtcaactact ataaaaaagt
    13681 gaattattct gttagagggc ttgaatttga attttcacgt acattgtgga aattcatgat
    13741 tttagctatt ttgtctgggc aaaatgattt atatcaaatc attcgagaaa agtatgatct
    13801 aaaaagacaa atggaacatc tttattctca tccaggacta tccgaaaaac ttacagcgag
    13861 attgtttgtt tggaatgagg cactttttaa atgggtattt tctattatta gatatctata
    13921 taaaaaaaga tggagatgaa taaacgaaat agattatctg aacaagaaat aaaaaaagta
    13981 gaacttgacg ctttattgta tattcggaaa atttgtcagc aatatcatct tcgctattat
    14041 ttagcttggg gtactttgtt gggagccgtt aggcataaag gatttattcc ttgggatgat
    14101 gatattgata taatgatgcc acgttcagat tatgagcgat tattggagtt agttccttcc
    14161 ttgagacata gttattataa aatcttaagt aatccaaaga atgaggatta ttattatact
    14221 catgcaaaaa tgatagatac tcgtactttg tgtgtggaaa atgatttgca aactattcaa
    14281 aatatgggga tttgggttga tattttcccc ttag
//
