LOCUS       c00023_gnlPro..        12764 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GHOPMKBK_23.
ACCESSION   c00023_gnlPro..
VERSION     c00023_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 19:41:48
            Original ID  :: gnl|Prokka|GHOPMKBK_23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12764
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12764
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:2764]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..2764
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..12764
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12764
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             2..1972
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 201.7; E-value:
                     7e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_1"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.2e-61, bitscore:
                     201.7, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.9e-36,
                     bitscore: 117.7, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="IDSKIPEGPVAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLAGAS
                     AAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDY
                     RAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGTLDNRSFGGAQVSRTFYAKGQTGQQ
                     LLLGAYSALSRQVNVGTVKLYTRYEMQDVVIVDGRARGIIAKNLVTGELERFAAHAVVI
                     ATGGYGNAYFLSTNAMGCNCTAAISCYRKGAVFANPAYVQIHPTCIPVHGDKQSKLTLM
                     SESLRNDGRIWVPKKKEDAVKLQKGEIKGSDIPEEDRDYYLERRYPAFGNLVPRDVASR
                     AAKERCDAGFGVNNTGLAVFLDFSEAINRLGIDIVLQRYGNLFDMYEEITDVNPGELAK
                     EINGVKYYNPMMIYPAIHYTMGGIWVDYELQTTIKGLFAIGECNFSDHGANRLGASALM
                     QGLADGYFVLPYTIQNYLADQITVPRFSTDLPEFAEAEKAVQAKIDKFMSIQGKESVDS
                     IHKKLGHVMWEYVGMGRTAEGLKKGIAELKEIRKEFETNLFIPGSKEGMNVELDKAIRL
                     YDFITMGELVAYDALNRNESCGGHFREEYQTEEGEAKRDDENFFYVACWEYQGDDEKAP
                     VLYKEPLVYEAIKVQTRNYKS"
     CDS             2009..2764
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_2"
                     /sec_met_domain="Fer4_7 (E-value: 7.9e-12, bitscore: 38.5,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 5.7e-25, bitscore: 80.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.5e-06, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQAGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISERKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFQDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             complement(2886..3725)
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MPSICQGTWDCQICPKAVSNAITHVIYQRGFHKPAQRCEENFILF
                     LIKGEMLVNSKEYAGTMLKEGEFILQAIDSTFEMLAMLECECIYYRFIQPELFCDSRFN
                     HIMKDVSPPLIYSPIKIVPELQYFLQGSITYLKGNKVCRDLLSLKRKELAFVLGYYYSD
                     YDLSSLVHPLSKYINSFHYFVIQNYKKVKTVEELAQLGGYTLSTFRRIFNNVFHEPVYE
                     WMLARRKEGILDDLNNSAYSISEICYKYGFESLPHFSNFCKKSFGASPRNLRGQNRS"
     CDS             complement(4024..5022)
                     /locus_tag="ctg23_4"
                     /transl_table=11
                     /translation="MKKILLAVTAALAIMSCSQNEEFEAPNQQTKIDFTSVVRKATRAT
                     DTNSNNFLGFTVSSYITDGDYNGTDALGAAYMDGISYTKDNAAAPWTTTDKGTYYWPSI
                     SSGKKVQFFAYPTTDPTSYSLPDASYPTISFTVDGTPADQKDLVVAHATNVTSESSKVA
                     DGTLTLDFKHVLTRINFAFIPDDPLLTYAVTAVSIADVKGGTGKYSFNADNGEWNLAAA
                     ATSSYSYAVKQSADKVENKNYYSLADTNASWMLFPQEVNGKVISITYSTKQGAMEVFSG
                     TKKVTLPSDAKWTVGQNVLYVLTLPAGAAKVGLNTEVSEWNTADEKEETAK"
     CDS             complement(5078..6061)
                     /locus_tag="ctg23_5"
                     /transl_table=11
                     /translation="MLLVLLSSLLVLNGCSRRDILDDYPVSGVEISLNWDGVTDKLPEG
                     IRVIFYPKDGEGKKVDRYLSVRGGEMKVPPGRYSVVAYNYNTESIRIRGEESYETIEAY
                     TGNCNGLGITGTEKMVWSPDSLYVLNIDELKIDKSEEVLSLDWKLESVVKKYSFAIEVK
                     GLEYVTAIVGCINGLSDCYHIGKGYGASSSQPIYFEVKKDGNKVVAYFTAFKQAKEMSV
                     PTRISESRSATSRGVGDIKLILRFIKTDNTVQEAAIDVTEIIETLEDTGTGDDGKQDPP
                     PEIELPSDDKIEVDKPELPPNPDGGGGMDGNVDGWGPEDNVELPVI"
     CDS             complement(6089..7366)
                     /locus_tag="ctg23_6"
                     /transl_table=11
                     /translation="MKHGIFILAILMALLSLPESGYAAVPFFTVINDTIRRVVIYFDAN
                     ETNVNHCYRSNKEAIITLDSLLSGNSDTKYITALNVVSFVSPDGDESYNKSLVTKRNNS
                     IKEFLRRYELVNNVDKIHFCSKGEDWLEFRKLVASDTNLPDREEVLMLIDYHKDDIAKR
                     KQLLRKLNRGAAYRYMVRNVFPELRRSVITIVGETGIIDREAFEPVSSVSGLFVSNQEE
                     ALPKNQPDKPVGESEDKQTCEVDMSEAEEPVKSKTVLAVKNNLLYDLALAPNIEVEIPI
                     GKRWSLNTEYKCPWWLNSKHDFCYQLLSGGMEGRFWLGNRQKRDRLTGHFIGLYAEGGI
                     YDFQLRGDGYQGKYYGAAGVTYGYAKQLAQHFSLEFSLGIGYLTTEYKKYTPYEGDIVW
                     TNSGRYNFIGPTKAKVSLVWLITTKR"
     CDS             complement(7600..8088)
                     /locus_tag="ctg23_7"
                     /transl_table=11
                     /translation="MGLEYVVTKRVFGFDKDKNEKYVAKSVRSGKVNFAKMCRKVSELC
                     GVHRKVVDLVVSGLVDKMAEDIDDGKSVQMGEFGIFTPTIRAKSTDDEKEVSSKSIVQR
                     KILFYPGKIFKNTLEDMSITRRAEIETDYTDGSSNGGNNGGNPDSGDDGKGEAPDPAA"
     CDS             8303..8446
                     /locus_tag="ctg23_8"
                     /transl_table=11
                     /translation="MFNTLTYQWIAIEILTAKSLPVTFTLNVYKQRRLQPHHRLQPDLF
                     IK"
     CDS             complement(8473..10248)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_9"
                     /sec_met_domain="HMGL-like (E-value: 5.1e-18, bitscore:
                     58.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 3e-18, bitscore: 59.0,
                     seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKEIKFSLVYRDMWQSSGKYQPRVDQLVRIAPLIVEMGCFTRVE
                     TNGGAFEQVNLLYGENPNKAVRAFTAPFREAGIQTHMLDRGLNALRMYPVPADVRKLMY
                     KVKHAQGVDITRIFCGLNETRNIIPSIKYALEAGMIPQATLCITYSPVHTVEYYARIAD
                     QLIEAGAPEICLKDMAGIGRPGMLGQLVRTIKEKHPDVLIQYHGHSGPGLSMASILEVC
                     ENGADIIDVAMEPMSWGKVHPDVISVQAMLKDLGFQVPDINMKAYMKARAMTQEFIDDF
                     LGYFMDPTNKYMSSLLLKCGLPGGMMGSMMADLKGVHSGINMILRSKNEPELSLDDLLV
                     MLFDEVEYVWPKLGYPPLVTPFSQYVKNVALMNLMQLVKGEERWTMIDNHTWDMILGKS
                     GRLPGTLAPEIIELAKSKGYEFVDTDPQLNYPDALDDYRKEMDENGWEYGEDDEELFEL
                     AMHDRQYRDYKSGVAKKRFEDELQHAKDASMAKSGYSEEDIKKLKRAKADPVIAPDNGQ
                     VLWEVSVEGPSIAPFIGRKYQHDEVFCYLSTPWGEYEKILTGFTGRVVEICAQQGATVR
                     KGDVIGYILRSDIFA"
     CDS             complement(10482..10874)
                     /locus_tag="ctg23_10"
                     /transl_table=11
                     /translation="MDTLKLHSHFENLLYVGRSVLTNTSSRIQRLFFKKEMCIYEYLFK
                     EEASKGIEIVVDNAVLVCVFENDICNKSILYLNDSTNVTSYINYCNSTFEYDKLRDRWI
                     MPDGYLTLFMPNDDFEKRFAFVQTLV"
     CDS             complement(11369..11590)
                     /locus_tag="ctg23_11"
                     /transl_table=11
                     /translation="MRRILSFAVLAALYFPGCTTSKNAVRCLSRWIKDCNPLTKELVPT
                     GYMPYNHRYLTMKQYKIITKHLGDPYED"
ORIGIN
        1 gatagattca aaaattccag aaggcccggt ggctgagaaa tggaccaact ataaagctca
       61 ccagaaattg gtgaaccccg ctaataaacg ccgtttggac atcatcgttg tgggtacggg
      121 tctggcaggt gcttctgccg ctgcttcact cggtgaaatg ggtttcagag tattcaattt
      181 ctgtattcag gattctcccc gtcgtgcaca ctctatcgct gcacagggtg gtatcaatgc
      241 tgcaaagaat tatcaaaatg acggtgactc cgtttaccgt ctgttctacg atactgtaaa
      301 aggtggtgac tatcgtgccc gtgaagctaa cgtatatcgt ctggctgaag tgtctaacgc
      361 tatcatcgac caatgtgtag cacaaggtgt tcctttcgct cgcgaatatg gtggtacact
      421 ggacaaccgt tctttcggtg gtgcacaggt atcccgtact ttctacgcta aaggccagac
      481 cggtcagcag ttgttgctgg gtgcttactc tgcattgagc cgtcaggtaa acgtaggtac
      541 tgtaaaactg tacactcgtt atgaaatgca agatgtggtg atcgttgacg gacgtgctcg
      601 cggtatcatc gctaaaaatc ttgtaacagg tgaactggaa cgctttgccg ctcacgctgt
      661 agttatcgct accggtggtt atggtaatgc ttacttcctg tctaccaacg ctatgggatg
      721 taactgtaca gctgctatct cttgctaccg caagggtgct gtattcgcta accctgctta
      781 cgttcagatt cacccgactt gtatcccggt acacggtgac aagcagtcta aactgacttt
      841 gatgtctgaa tctctccgta acgacggtcg tatctgggtt ccgaagaaga aagaagatgc
      901 tgtgaaactt caaaaaggcg aaatcaaagg aagtgatatt cctgaagaag accgcgacta
      961 ttacttggaa cgccgctatc cggcattcgg taacctggtt ccgcgtgacg ttgccagccg
     1021 tgctgctaaa gaacgttgcg acgcaggttt cggtgtaaac aacactggtt tagccgtatt
     1081 ccttgacttc tctgaagcta tcaaccgctt gggtatcgac atcgttctcc aacgttatgg
     1141 taacctcttc gatatgtatg aagaaatcac tgacgttaat ccgggagaac tggcaaaaga
     1201 aattaatggc gtaaaatatt ataatccgat gatgatttat ccggctatcc actatacaat
     1261 gggtggtatc tgggtagact acgaactgca aaccactatc aagggtctgt tcgctatcgg
     1321 tgaatgtaac ttctccgacc acggtgcaaa ccgcctcggt gcttctgcat tgatgcaagg
     1381 tttggctgac ggttacttcg tattgcctta tacaatccag aattatctgg cagatcaaat
     1441 cactgttcct cgtttctcta ctgatcttcc tgaatttgct gaagcagaaa aggcagttca
     1501 agctaagatc gacaagttca tgagcatcca gggtaaagaa tctgttgatt ctatccacaa
     1561 gaaactgggt catgttatgt gggaatatgt aggtatggga cgtacggcag aaggcttgaa
     1621 gaaaggtatt gccgaactga aagaaatccg caaggaattc gaaacgaatc tgtttatccc
     1681 cggttctaaa gaaggtatga acgtagagct tgacaaagca atccgtctgt acgacttcat
     1741 cacaatgggt gagcttgttg cttacgatgc attgaaccgt aacgaaagtt gtggtggtca
     1801 cttccgtgaa gaataccaga ctgaagaagg agaagctaaa cgtgatgacg aaaacttctt
     1861 ctatgtagca tgctgggaat atcaaggtga cgatgaaaaa gctccggtgt tgtacaaaga
     1921 accgctggta tacgaagcta tcaaggttca aacccgtaac tacaagagct aatcggtgaa
     1981 gttaaacatt taaaagaatt agaagaaaat ggataaaaat atatcattta cactgaaggt
     2041 atggcgccaa gctggtccga aggctaaagg tgcttttgaa acctaccaaa tgaaagatat
     2101 ccccggcgat acttccttcc tcgaaatgct ggatattctg aacgaacagc tcatcagcga
     2161 aagaaaagaa ccggtagtat tcgaccacga ttgccgcgaa ggtatctgcg gtatgtgttc
     2221 tctttacatc aatggacacc cgcacggtcc tgcaacaggt gctactactt gtcagatcta
     2281 tatgcgtcgt ttccaggatg gtgatacgat tactgttgaa ccttggcgtt cggccggttt
     2341 ccctgtaatc aaggacttga tggtagaccg tactgcttat gacaagatta tgcaagctgg
     2401 tggttacgtg agcgtacgta caggtgctcc gcaggatgct aacgctatcc tgattccgaa
     2461 gcctatcgct gacgaagcta tggatgctgc ttcttgtatc ggttgtggtg cttgtgtagc
     2521 tgcatgtaag aatggttctg ctatgttgtt cgtttctgca aaagttagcc agttgaactt
     2581 gctgccgcaa ggtaaaccgg aagctttgcg tcgtgcaaaa gctatgttgt caaagatgga
     2641 tgaactggga ttcggtaact gtacaaacac tcgtgcttgt gaggctgaat gtccgaagaa
     2701 catctctatc agcaacatcg cccgcttgaa ccgtgacttc atcatcgcaa aattaaaaga
     2761 ctagaaattg ctagatttcg agagcgagag cttaatttga ttaatgacag aatcccctgc
     2821 cggctagtcc gacaggggat ttctttatat atgaatggat catgattatt attaataatc
     2881 agttatcatg aacggttttg tccacgcaaa ttacgtggag aagcgccgaa agatttctta
     2941 cagaaattag agaaatgggg taaggactca aaaccatatt tatagcatat ctcggaaata
     3001 ctataagcag aattattcaa gtcatcgaga ataccctctt tacggcgtgc cagcatccat
     3061 tcataaactg gttcatgaaa gacattattg aaaatacgac ggaatgtgct aagggtatat
     3121 cctcctaatt gggctagttc ttctacagtc tttactttct tatagttttg aataacaaag
     3181 tagtggaaac tattgatgta cttagagagc ggatgcacca gactcgagag gtcataatca
     3241 gaataataat accccaacac aaatgccaac tctttccgct tgagagacaa caaatcccgg
     3301 cagactttat ttccttttaa ataagtgatg gaaccctgca aaaaatattg tagttcagga
     3361 actatcttta ttggggaata gataagtgga ggcgatacat ctttcattat atgattgaaa
     3421 cgagaatcac aaaacaattc cggttgaata aaacggtaat agatgcactc acattcgagc
     3481 atggcaagca tctcaaatgt agaatcaata gcttgaagta taaattcacc ttctttgagc
     3541 atggtaccgg catattcctt actattaacc agcatttctc ctttaatcaa gaaaagaata
     3601 aaattttcct cacacctctg agctggttta tgaaaaccac gctgataaat aacatgagta
     3661 atagcattgc tcactgcttt cggacatatt tgacaatccc aagttccttg acaaatagat
     3721 ggcataagct ggctgtgttt gtatttgttt atgctgccaa caaaaatata tgaaagattt
     3781 catattgcca taaaaaaagg gaagaaaagt gaaaaagaag ttgcacgaag aatctaaaac
     3841 atatctagtt ttgaaaactg aactaaatct ccatataaaa gataaataac ctcacaagat
     3901 ctcatacaaa gttctgtgtt aataaagaaa ccctagctcc tcgaaaagaa gagctaggat
     3961 ttaaaatatg cttaacctag aaataattct catttatgct aaatcatgga cagtgccatt
     4021 ttatcattta gcagtctcct ctttttcgtc tgcagtattc cattcgctaa cctctgtatt
     4081 aagcccaact ttagcagcac cggcaggtaa tgttaataca tatagcacat tttgaccaac
     4141 tgtccatttg gcatcactag gaagagttac ttttttagtt cctgaaaaga cttccatcgc
     4201 accctgtttc gttgaatatg ttattgatat aaccttacca tttacttctt gaggaaatag
     4261 catccaagat gcattagtat cagccaaaga ataataattc ttattttcaa ccttatctgc
     4321 tgattgttta acagcataac tatatgatga agtagcagca gcagccaaat tccattcacc
     4381 attatctgca ttaaaactat atttacctgt tccaccttta acatcagcta tactaacagc
     4441 agtcactgca taagtaagca aaggatcatc aggaataaac gcaaaattta tacgggttag
     4501 aacatgttta aaatctaggg tcagtgtacc atcagctact ttactcgact ctgaagtaac
     4561 attagttgca tgtgcaacaa ccaaatcttt ttgatccgca ggagtgccat caacagtgaa
     4621 agatattgta gggtagctag cgtcaggaag agaataggac gtaggatctg tcgttgggta
     4681 tgcaaagaat tgtacttttt ttcctgaact tattgatggc caataatacg ttcctttatc
     4741 ggtagtagtc caaggtgcag cagcattatc tttcgtatat gagattccat ccatgtatgc
     4801 agctcctaaa gcatctgttc cattatagtc accatctgta atataagaac ttacagtgaa
     4861 ccctaaaaag ttattactat ttgtatctgt agctcttgta gctttcctta ctactgaagt
     4921 aaaatcaatc tttgtttgtt gattcggcgc ctcaaattcc tcattttgtg agcaactcat
     4981 aattgctaaa gcagctgtta ctgccaataa aattttcttc ataactgtat tttttaaaag
     5041 tttataatat tgttctattt tgtttataac atctatttta aatcacaggt aattcaacat
     5101 tatcttccgg tccccaccca tcaacattgc catccattcc tccaccccca tcaggattcg
     5161 gcggtaactc tggcttatca acctcaatct tatcatcaga cggtaactca atctccggtg
     5221 gagggtcctg ttttccatca tctcctgttc cagtatcttc aagtgtctct attatttcag
     5281 taacatcaat tgctgcttct tgcaccgtat tatccgtttt gataaatctc aagatcaact
     5341 ttatatcgcc tacaccacgg gaagttgcgc tccttgattc tgatattcgt gtcgggactg
     5401 acatttcctt tgcctgcttg aaagctgtga aatacgccac taccttatta ccatctttct
     5461 ttacctcaaa atagataggc tgcgaggaag atgctccata acctttacca atgtggtaac
     5521 aatcagatag tccgttaata caccctacga ttgctgttac gtactccaaa cccttgacct
     5581 ctatcgcaaa agaatacttc ttcactaccg attccagttt ccaatccaaa gaaagcacct
     5641 cttcactctt atctattttc agttcatcaa tattcagcac atacagtgag tccggtgacc
     5701 aaaccatctt ttccgttcct gtaatcccta aaccattgca gtttcctgta taagcctcta
     5761 tcgtttcata ggactcttct cctcggatac gtatggactc cgtattatag ttgtaagcta
     5821 caaccgaata tcgtcccgga ggaactttca tttctccacc tcgtaccgaa aggtacctgt
     5881 ccactttttt accctcacca tctttcggat aaaatataac ccggatacct tctggtaatt
     5941 tatctgttac tccatcccag tttaatgaaa tttctacccc acttacagga taatcatcca
     6001 atatatcgcg acggctacac ccgtttagca ccagcagcga ggacagaagc acaagaagca
     6061 tgaatcttgc atttcgcata acgccctcct atctctttgt tgttatcaac cataccaaag
     6121 aaacttttgc tttggtagga ccaataaagt tataacgccc actatttgtc catacaatat
     6181 ccccctcata aggagtatat ttcttatatt ctgttgtcaa ataccctatg ccaagactga
     6241 attcaaggga aaagtgctgt gctaattgct ttgcatatcc ataagtcact ccagcagctc
     6301 catagtactt accctgatac ccatctccac gtaactggaa atcgtatatt ccaccttcag
     6361 cataaagtcc aataaaatgt ccagtcaatc ggtcgcgctt ctgccggttt cccagccaaa
     6421 aacgtccttc catgcctcca gaaaggagct gatagcagaa atcgtgttta ctattcaacc
     6481 accacggaca tttatattca gtattcaaag accacctctt acctatcgga atttctactt
     6541 ctatattcgg tgccaatgcc aaatcatata atagattgtt ctttactgca agcactgttt
     6601 tgcttttcac cggctcttct gcctccgaca tatcgacctc acaggtctgt ttatcttcac
     6661 tttctcccac aggcttatca ggttgattct tcggaagcgc ctcttcctga ttcgaaacaa
     6721 acaacccgga gacagaagat accggttcaa aagcctctct atctattatc ccagtttctc
     6781 cgacaatcgt tataacagac cgcctcaatt ccggaaatac attacgaacc atatatcggt
     6841 aggcggctcc ccgatttagc ttacgcaaca gttgctttct tttggcgata tcatccttat
     6901 gatagtcaat caacatcagc acttcttccc ggtcgggtaa gttggtgtca gatgccacca
     6961 acttacgaaa ctccaaccaa tcctctccct ttgaacagaa atgaatctta tcaacattat
     7021 taactaattc atatcgcctc aagaattcct ttatcgagtt atttctctta gtaaccaaac
     7081 ttttattata agattcgtca ccatcaggag aaacaaaact cactacattt aacgctgtta
     7141 tatatttcgt atccgaattt ccggacaaca aggaatctaa tgttataatt gcctctttat
     7201 tactcctata acaatgattc acattcgttt cattcgcatc gaaatatatc accacccgtc
     7261 ggattgtatc attaataaca gtaaaaaatg gtaccgcagc atacccactt tctggaaggc
     7321 ttaacaaagc cataagaata gccaagataa agataccatg tttcattgtc gttcgtttct
     7381 gttgacaaat atagaagtta gaaaataaat caaatcatac tttcaggaga aaatacaggc
     7441 cctgaaaggt tctgtgaaac gattgaaacg attttgcaag tttgaggagt ataaaaggca
     7501 gaaaatcata taaaaagaat gcacagataa ccaatctatc gatcgattct ctgtgcattc
     7561 actaattaaa ggcttgcttt aatacaaagt tcagtccaat tatgcagccg ggtccggtgc
     7621 ttcccctttg ccatcatcgc ccgaatcagg gttaccccca ttattccccc cattactact
     7681 tccgtccgta taatccgttt caatttccgc acggcgggta atactcatat cttccagcgt
     7741 atttttgaag atttttcccg gatagaataa gatctttctc tgaacgatcg acttggatga
     7801 gacctccttt tcgtcatccg tactcttagc acggatagta ggagtgaaga taccaaactc
     7861 acccatctgc acgctctttc catcatcaat atcctccgcc atcttatcca ccagaccact
     7921 gacgaccaaa tctaccacct tacgatggac accacaaagc tcacttactt tccgacacat
     7981 ctttgcaaaa ttcaccttac cggaacgaac cgattttgcc acatactttt cgtttttgtc
     8041 cttgtcaaaa ccgaacactc tttttgttac tacgtactct aaacccataa ttgttaaagt
     8101 ttaattggtt aaaaaaataa aggttatctg tttgtcattc tctttgtttg aatgactctg
     8161 caaaggtata tcaaccgtaa aacgtccggt ccccttttgt ctcctttcat cgtttggaat
     8221 caattattat cggaagagaa tattgctagt tatcaacagg atatatcaaa gaattatttt
     8281 tttcataaaa tgcgtatttt ccatgttcaa cactctaact tatcaatgga tagccattga
     8341 aattctaaca gctaaaagcc ttcctgtaac ttttacattg aatgtctaca aacaaagaag
     8401 gctgcaacct catcacagat tgcagcctga cctttttata aagtaaccta tagtctaact
     8461 ctcatagaaa tctcacgcaa agatatcgct ccgcagaata taaccgataa catctccctt
     8521 acgtacggta gcgccttgtt gtgcacatat ttccaccaca cgtccggtaa atccggtcag
     8581 aatcttttca tattctcccc atggagtaga aaggtagcaa aagacttcgt catgctgata
     8641 tttacgtccg atgaatggcg caatggatgg tccctctacg gaaacttccc aaagtacctg
     8701 cccgttgtcg ggagcaataa ccggatccgc cttggcacgt ttcaatttct tgatatcttc
     8761 ctcggaataa ccactctttg ccatggatgc atccttagca tgttgtaatt catcctcaaa
     8821 acgtttcttg gcaacaccgg acttataatc gcgatactga cgatcgtgca tagccagttc
     8881 aaaaagttct tcgtcatcct ctccatactc ccagccattc tcatccattt ccttgcgata
     8941 atcatccaaa gcatccggat aattcaactg cggatcagta tcgacaaact catatccttt
     9001 agacttcgcc aattctataa tctccggagc aagcgtaccc ggcagacgtc cactcttacc
     9061 cagaatcata tcccaggtat ggttgtctat cattgtccag cgctcttccc cttttaccaa
     9121 ttgcataaga ttcatcaatg caacattctt cacatactga ctgaaaggag tcaccaaagg
     9181 aggataaccc aacttaggcc acacatattc cacttcgtcg aaaagcatta ccagcaaatc
     9241 gtcaagacta agttcaggtt cgttcttact ccgtaatatc atattgatac cggaatgtac
     9301 ccctttcaaa tctgccatca tagaacccat cataccaccc ggcaaaccac atttcaataa
     9361 aagcgaagac atatatttgt tggtaggatc catgaagtaa cccaaaaagt catctatgaa
     9421 ttcctgcgtc atcgcacgag ccttcatata tgctttcata ttaatatcgg gaacctgaaa
     9481 acctaaatct ttcaacattg cctgtaccga gatcacgtcc ggatgcactt taccccaaga
     9541 catgggctcc atagccacat caataatatc cgcaccattc tcgcaaacct cgagaataga
     9601 tgccatagac aatcccggtc cgctatgacc atgatattgt atcaatacat ccggatgttt
     9661 ttccttgata gtcctgacca attgccccaa catacccggg cgaccgatac ctgccatatc
     9721 tttcaaacat atttcaggtg caccggcctc aatcagttga tcggcaattc gggcataata
     9781 ctcaacggta tgcaccggag aatatgtgat gcaaagagtc gcctgcggaa tcatacccgc
     9841 ttccagagca tatttaatgg agggaattat gtttctcgtc tcattcagtc cacagaagat
     9901 acgggtgata tccacccctt gtgcatgctt gactttatac atcaatttac gcacatctgc
     9961 cggaaccgga tacatacgca atgcattcaa accacgatcg agcatatgcg tttgaatgcc
    10021 cgcttctcta aaaggtgcgg taaaagcacg gacggcttta ttaggatttt cgccgtacaa
    10081 tagattcact tgctcaaaag cacctccatt cgtttcaact cttgtaaaac agcccatctc
    10141 aacaatcaat ggagctatac gtacaagctg gtcaacccga ggttgatact taccggaaga
    10201 ttgccacata tcccgataaa caagactgaa tttgatttcc tttttcatca tagccaataa
    10261 taagtgattt ttttctttgg ttaacttcac atatacaaat ataaaggttt gttttgacat
    10321 atagtcaaaa atagccttta aaaaatgggt aaatagagat gttttacatc ataatgaaag
    10381 caaacaatgc ctacactctt ccaattataa taaataacaa atcaaattgt ctaatgttca
    10441 gatatatccc cttaagaatc caaaggcttc acgaagttta ttcatactaa ggtttgcacg
    10501 aatgcaaatc gcttttcaaa gtcatcattc ggcataaaaa gggtaagata accatcaggc
    10561 ataatccatc tatcacgaag tttatcatat tcaaaagtac tattgcaata attaatataa
    10621 gatgttacat tagtggagtc attaagataa agaatagatt tattacagat atcattttca
    10681 aaaacacaaa ctaagacagc attgtccact acaatttcaa tgcctttact tgcttcctct
    10741 ttaaacaagt attcatatat acacatctct tttttaaaaa acaatctttg aatgcggcta
    10801 cttgtattag tgagcacgct tcttcccaca tacagcaaat tttcaaagtg tgaatgcaat
    10861 ttaagagtat ccatttcatc atttttttat tgttattact ttgctaaata ttttatgact
    10921 gatctctctc atttaagatt cttgatttgc cagacataat ttattctcca aagtaacata
    10981 ttcacattca tatactcaca atcatatatg attgtatgat aagtttcaat taaaataaag
    11041 aattacaaga agaaacatct acccattcaa ggttacacaa ataaagatga aatgagactg
    11101 tctttaataa tgtagtgatt attaaccaaa cacacaagga tttcgtatat ttctcatttc
    11161 agtacaccga aaaaagttta tcttttctgt ataaacgact tttgagtttc taataaattc
    11221 tcaaggagtt tattagaaac ggtatccaag tttattaaaa acccgaatgt agctttcaga
    11281 agggtataca ttgaatttat gcaacaaaaa aggctgcaaa tcctataaaa ggttgcagcc
    11341 tcaagctttt tatcgggtcg tctataccct aatcctcata aggatctcct agatgttttg
    11401 ttataatctt atactgtttc atcgtcagat aacgatgatt atacggcata taaccggtcg
    11461 gtacaagttc tttggtcaac gggttacagt ctttaatcca tcggcttaga caacgcactg
    11521 catttttact ggtcgtacat ccggggaagt acaatgcagc taatacagca aaagataaga
    11581 ttcgtctcat ttcgttttta aagttttaat ttgtcgtttc attgtttctt tcgttataca
    11641 aatatacaac atcaaaaagc gtttgtcaag tcttttgggc ttttgccgtt aatataaagg
    11701 attatttatc catacaaagc tgattttcaa tcaattaagc tatcatttta ttttttcaat
    11761 atttgacatt aaaattattg caaagcactt aaaataaagc aatatctttc ctttaaaagg
    11821 aacaccccat tggttttaaa ggaacgatgc cttggtttta aaccaacggg gcgttccttt
    11881 taaaccaaga aaacacttat attcagacct tattttctaa ttttcctaga agctgcaata
    11941 gtattcagga agacttactt tcctccccat tacttacccc aaaagcattc tactttagcc
    12001 attaagagtg catcgtgtac gataacagtg aaaatcagtg aaagaattta aaagagaaac
    12061 aaatacaaca gaattatttg gaggttagtt tgcaaagaca tacatttgtc atgtgatttt
    12121 tttcatagta ttagatttaa ggttaacaaa ggttggagca aggcgttgct ccttttttta
    12181 tatccatata tgaggttagt ttatacgagt taattcaata actgatacat tcctcctgcc
    12241 aatacacgaa ctactccttt catttccagt tcaaaaagaa tagcatttat tttatgtacg
    12301 ggaatatctg cttctactac cagagaatta atctgtaaat tcccctgttt ctccaggata
    12361 gagacaatct tctgttcttc ttcggacaag tcgagaaaaa gactacgttg cacatttact
    12421 ttctcggaag aagttgccgg tatattccat cccattgcct gtacaagatc ttcagccgat
    12481 aatagtaagg aagccttatt atccctaatc aatcgattac atccctttga atattcatca
    12541 tttatccggc cgggaaaagc aaaacaatca cggtgataac tttcagcaag ttcagcagtg
    12601 attaatgagc ctcctttttc tgccgattca atgacaactg tagcatcaca catacctgcg
    12661 acaatacggt tacgactgac gaaattatgt ttgtcgggat tcgtaccgga cagaaattca
    12721 gtcaatagtc ctcctttttc gagcatatca atggctgttt ttcg
//
