LOCUS       c00004_gnlPro..        15253 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JLJPLKGI_4.
ACCESSION   c00004_gnlPro..
VERSION     c00004_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:47:41
            Original ID  :: gnl|Prokka|JLJPLKGI_4
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15253
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15253
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:5253]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..5253
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15253
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15253
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..1076
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_1"
                     /sec_met_domain="ILVD_EDD (E-value: 2e-126, bitscore:
                     415.0, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="YEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHE
                     AGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGGLIDTSVL
                     RVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYKELDKDRANGC
                     IRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACEGILG
                     GRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIG
                     HVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRYVPKSLKA
                     YASMVSSADKGAVRLID"
     CDS             1124..2821
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-46, bitscore:
                     150.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRTFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTKERSIVTSGGLGTMGFGLPAAIGATFGRPDRMVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKAAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             2840..3403
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_3"
                     /sec_met_domain="ALS_ss_C (E-value: 4.6e-19, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             3403..4146
                     /locus_tag="ctg4_4"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGGIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEA
                     NENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             4210..5253
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_5"
                     /sec_met_domain="IlvN (E-value: 1.2e-46, bitscore: 150.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.5e-39, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFSIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(5789..7735)
                     /locus_tag="ctg4_6"
                     /transl_table=11
                     /translation="MKYIFVSGRRFITFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHPAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKMQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWVDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYINRIGKARILNESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLAKHAFYR
                     KLIQYIRQEAVSS"
     CDS             7802..10045
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DLKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDDFMQIGAVIMANACGPCIGQWKRHTDDPTRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPVGDELPLRGFTSGNEG
                     YITPGGTKTAINVNPASQRLQLLTPFPAWDGQDILNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNNVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQEHD
                     LLSVIGLPDFAPGRNLTVVLHHEDGTKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             10060..11250
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQSVVNAAVQ
                     KAYGGKRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLN
                     VALRQTLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEK
                     FYQFLKNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNI
                     MKFTEGGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLN
                     GDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVM
                     MLEYLGWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK"
     CDS             11276..12619
                     /locus_tag="ctg4_9"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFRELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             complement(12635..12763)
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="MFFLKQVTPDVQPGTTKMYNWGLPRRTCRDYRDVRLRLVIIA"
     CDS             complement(13016..13651)
                     /locus_tag="ctg4_11"
                     /transl_table=11
                     /translation="MGFLFEKCTFAVLDEDTIKECDPFSCGHQDLDDFFHNDAPLYNAQ
                     LLGKSYCFRSDKKPSDIVCAFTVSNDSIRVNILPNSREKKVQKDIPRAKQMHRYPGVLI
                     GRLGINKEYKHQGIGSDLMTFIKSWFIDAGNKTGCRFLIVDAYNENIPLNYYLKNGFKY
                     LFSTEAQEVEYTGFETGTHLKTRLMYFDLIDIIPYPNNSSKDAIDGNY"
     CDS             complement(13655..13807)
                     /locus_tag="ctg4_12"
                     /transl_table=11
                     /translation="MEIKAIPTLKGKEAEHFVKAADKAYKNQNKQDFSKHVLEARAVLK
                     KAKML"
     CDS             13985..14746
                     /locus_tag="ctg4_13"
                     /transl_table=11
                     /translation="MSIAAFNLFLGVMSLTALIVFIALYFVKAGYGIFRTASWGVAISN
                     KLAWILMEAPVFLVMCWMWIHSERRFDPVILTFFVFFQIHYFQRAFVFPLLLTGKSKMP
                     LAIMSMGILFNLLNGYMQGEWIFYLSPEGMYHSGWFTSAWFIAGSLLFFAGMLMNWHSD
                     YIIRHLRKPGDTRHYLPQKGMYRYVTSANYLGEIIEWAGWAILTCSLSGLVFFWWTVAN
                     LVPRANAIWHRYREEFGSEVGERKRVFPFIY"
ORIGIN
        1 attatgaaga aggtgacgaa agtgtacttc cccgcagcat agctacccgt caggcattcc
       61 tcaatgccat gacgctggat attgcgatgg gcggttctac caatacggtg cttcacctgt
      121 tggccgtggc acatgaggca ggagtcgatt tcaagatgga cgacatcgat atgctgtcac
      181 gcaagacacc ctgcctgtgt aaagtcgctc cgaatactca aaaatatcat attcaggacg
      241 ttaaccgtgc gggtggcatc attgctatcc tggcagagtt ggcaaaaggc ggtctgattg
      301 atacttccgt tctccgtgtg gatggcatgt cgctggcgga agcgatcgat caatattcaa
      361 ttaccagccc gaacgtaaca gaaaaagcaa tgagtaagta ttcaagtgcg gcgggaaaca
      421 gattcaatct cgtacttggt tctcagggag cttattataa ggaattagat aaagatcgtg
      481 cgaacggatg tatccgtgat ctggagcacg cctatagcaa ggacggaggc ttggcggtac
      541 tgaaaggaaa tatcgctcag gacggttgcg tagtaaaaac ggcgggtgta gacgaaagca
      601 tctggaagtt taccggacct gccaaagtat tcgactcaca agaagcagcc tgtgaaggca
      661 tcctcggagg ccgagtcgtc agcggcgacg ttgtcgtcat cacgcacgaa ggtccgaagg
      721 gcggtcctgg tatgcaggaa atgctttacc cgacttctta tatcaaatcc cgtcacctcg
      781 gcaaagaatg tgccttgatt accgacggac gtttcagtgg tggaacttcc ggattgagta
      841 tcggacacgt ttctcccgaa gccgctgccg gaggtaatat aggaaaaata gtagatggag
      901 atatcatcga aatcgacatt cccgcccgaa cgattaacgt gcgactaaca gatgaagaac
      961 tggctgcccg cccgatgact cccgtcaccc gtgaccgtta cgtgccgaag agcctgaaag
     1021 catacgccag catggtaagc tctgccgata agggagcagt gagattaata gactgatcca
     1081 cttcattatc cattatgaat catccattat ccattaaaga actatgagta aggacttaat
     1141 aacaggcgca gaggcaatga tgcgctctct ggaacatcag ggagtgacta ccattttcgg
     1201 ttatcccggc ggttcaatca tgcctacgtt cgatgccctg tacgaccatc aaaatacatt
     1261 gaaccatatc ttggttcgcc atgaacaggg agctgcccat gcggcacaag gctacgcccg
     1321 tgtatcgggt aaagtcggtg tttgcttggt gacaagcggc cccggagcaa ccaatacgat
     1381 cacaggtatt gcagatgcaa tgatagacag tacgcctatc gttgtcattg caggacaggt
     1441 gggaacaggc tttcttggaa cagacgcttt tcaggaagtc gatctcgtag gtatcactca
     1501 gccaatcgct aaatggagct atcagattcg ccgtgccgaa gacgtagcct gggcaatagc
     1561 acgtgctttc tacattgcca gtagtggtcg tcccggtccg gtggtactcg actttgccaa
     1621 gaatgcgcag gttgaaaaaa cgaaatacga gccgacaaag caggagttta tccgcagcta
     1681 tgttccggtt cccgatacag acgaagaatc ggtaaaggct gccgccgaac tgatcaataa
     1741 cgccgaacgc ccgcttgtct tggtaggaca gggagtggaa ctgggaagcg ctcaggaaga
     1801 actgcgtacc tttatcgaaa aggcggatat gcccgcaggt tgtaccttgc tcggactttc
     1861 cgcattgcct accgaccatc cgttgaataa aggaatgctg ggtatgcacg gaaatctggg
     1921 accgaatatc aatactaaca aatgtgatgt actgattgct gtcggtatgc gtttcgacga
     1981 ccgtgtgacc ggtaatctgg ctacttacgc caaacaagcg aaagtgatcc attttgatat
     2041 tgatccggcg gaagtaaata agaatgtaaa ggtagacatt gccgttttgg gcgactgcaa
     2101 aaagacgctg gctgctgtga ccggactgct gaaaaagaac cggcacactg agtgggtcga
     2161 tagtttcaag gaatatgaag cggtagagga agaaaaagtc attcgtcccg aacttcatcc
     2221 tgcaacggat tcactgagta tgggcgaagt ggtgcgtgcg gtaagcgaag cgacccgtca
     2281 cgaagccata ttggtgacag atgtaggtca gaatcagatg atctctgccc gctactttaa
     2341 atataccaag gaacgtagta tcgttacttc gggcggactc ggcacgatgg gttttggcct
     2401 tccggcagct atcggagcta ctttcggccg tcccgaccgc atggtatgcg tatttatggg
     2461 tgacggcgga ctgcaaatga atattcagga gctgggtacg attatggaac agaaagctcc
     2521 ggtgaagatt atctgcctga acaataatta tctcggcaac gtgcgccaat ggcaggccat
     2581 gttctttaat cgccgttatt catttactcc gatgctgaat ccggattaca tgaaaatcgc
     2641 ttccgcctac gatattcctt ccaaacgtgt cttttcacgg gaggaattga aagcggccat
     2701 cgacgaaatg ctctcgacag acgggccgtt cctgctcgaa gcctgtgtgg tagaagaagg
     2761 caatgtcctc ccgatgaccc ctccgggcgg ttcagtcaat cagatgttgc tggaatgtta
     2821 atccttaatt tagaaagtta tgagtgataa gacattatat acgattatag ttcattctga
     2881 aaatatagcc ggattgctga atcaggtgac cgctgtattt acccgtcggc aaataaacat
     2941 cgagagtttg aacgtttctg cttcttccat taaaggagta cataaatata cgatcacagc
     3001 gtggactgat aaggacacta tcgaaaaggt ggtgaagcag atcgaaaaga agattgatgt
     3061 gattcaggcg cactatttta cggaagacga gatttatttc catgagatag ccttatataa
     3121 ggtatctact cctgcttttc aggagactcc ggaagcatct aaagtgatcc gcagatataa
     3181 tgcccgcatt gtagaggtga atccggtatt ctctatcgtt gagaagaacg gcatgagtga
     3241 agagattact tccctttacg aagaacttcg ggctttgaaa tgcgttctgc aatttgtccg
     3301 ttcgggtcgt gtggctatta ctaccagctg tttcgaacgt gtgaatgagt tcctggacgg
     3361 acaggaagcg aagtataagc aaagtaaaaa ggaacaggag taatgagtga agaaaataaa
     3421 atagggactt atcagtttgt ggcagagccg ttccacgtag attttaacgg ccgcctgaca
     3481 atgggcgtgc tgggaaatca tctgctgaat tgcgcaggtt ttcatgccag cgaccgtgga
     3541 tttggtattg ctacgctgaa cgaggacaat tacacatggg tgctttcccg tctggcgatc
     3601 gagctggacg agatgcctta ccaatacgag aagttctcgg ttcagacatg ggtggagaat
     3661 gtctatcgtc tctttaccga ccgtaacttt gctgtcattg acaaggatgg aaagaagatc
     3721 ggctatgccc gttccgtatg ggcgatgatc aatctgaata cccgtaagcc tgccgatctg
     3781 ttggcattgc atggaggagg catcgtcgat tatatatgcg atgaaccctg cccgatagaa
     3841 aagccttcgc gtatcaaggt gacaagcaat cagcctgttg cgacgctgac ggcaaaatac
     3901 agtgatatcg atattaacgg acacgtaaac agtattcgtt atatcgagca catacttgac
     3961 ttgtttccga tagaactgta tcagacgaaa cgtatccgcc ggtttgaaat ggcgtatgtg
     4021 gctgaaagtt atttcggaga tgaactctct ttcttctgtg atgaagcgaa tgaaaacgag
     4081 tttcatgtag aggtgaagaa aaacggcagc gaggtagtat gccgttccaa agtgatattt
     4141 gaataatata gagtataaaa tcaattaata acagatggcg caagtcatca aaacaaaaaa
     4201 acaaaaaaaa tggcacagtt gaattttggc ggaactgtag aaaatgtagt tatccgtgat
     4261 gaatttccat tggaaaaagc tcgtgaagta ttgaaaaatg aaacaatcgc tgtaatcggt
     4321 tatggcgtac aaggtcccgg acaggctctg aaccttcgtg ataacggttt caatgtaatc
     4381 gttggtcaac gccagggaaa gacatatgac aaagcggttg ctgacggatg ggttccgggt
     4441 gaaactttgt tcagtattga agaagcttgc gaaaaaggta cgatcattat gtgcctgttg
     4501 tctgatgcag cagtaatgtc tgtatggcct actatcaagc cttacctgac tgcaggaaaa
     4561 gctctttatt tctctcatgg ttttgctatt acatggagtg accgcacagg tgtagttcct
     4621 cctgcagata tcgacgtaat catggttgct cctaaaggtt cgggtacatc cttgcgtact
     4681 atgttccttg aaggtcgcgg cttgaactct tcttacgcta tctatcagga tgcaacaggc
     4741 aacgctatgg acagaacaat cgcactgggt atcggtatcg gttcaggtta tttgttcgaa
     4801 acaactttca tccgtgaagc tacttccgac ctgacaggcg aacgtggttc actgatggga
     4861 gctatccagg gtctgttgct ggcacaatac gaagtgttac gtgaaaacgg tcacactcct
     4921 tccgaagcat tcaacgaaac tgtagaagag ctgactcagt cattgatgcc gttgtttgca
     4981 aagaacggta tggactggat gtatgctaac tgctctacta cagctcaacg tggtgctctc
     5041 gactggatgg gccccttcca cgatgctatc aaaccggtag ttgaaaagtt gtatcacagt
     5101 gtgaagactg gtaacgaagc acagatttca atcgactcta actccaaacc ggattatcgt
     5161 gagaaactgg aagaagaact gaaagcattg cgcgaaagcg aaatgtggca gactgccgta
     5221 acagttcgta aacttcgtcc ggaaaataac taatcagact tatactatat aagtttttca
     5281 agaggcggga aaatcatctt ttcccgcctc ttctatgtgt ataccactct tttgaacgac
     5341 agaataagga tgaaagtagc aaaaaagatt aaaagacatg ggtagtatgg atgaaaaaaa
     5401 gcatttattg ttacctttgc gtcaacaaat aaaacagaat gagcaatgaa gacacttttt
     5461 actttcagaa gatcggtacg tgtgcagatg atttcttctt taataaatag tatatcagaa
     5521 cgttacatca aaagatattt aagttattct ctaccgaatg gtaggagtaa tgccatttca
     5581 agtcctttta atatttcgtg ttctattagt aattcatggg tatgatgcag aatttcattc
     5641 tgtagcagga atgagtatgc gttaaattgt atttaagaca gagcttttgg aacagaattt
     5701 agtgggaaaa taacattgtt tgttttgttt gtaagtggga gtcctctttc gtgagaaagg
     5761 gggcttcctt gtattttatc cctatgattc aggaagatac cgcttcctgc cggatatact
     5821 gtatcagttt ccggtagaac gcatgcttgg caagcgtcgt tgcatcccct aaaatcacga
     5881 gtttcatccg ggcgcgggta atggctacgt tcattcgtct taaatcattc agaaaaccga
     5941 tctgtccgtc ctcattcgcc cggacaaggc tgataaatac gacatcccgt tcctgtccct
     6001 gaaagccgtc taccgtgttg accgtgatga ggctgcggaa agggcgtaga aaactgcttc
     6061 ccctgatttt acttctcaga tattgcactt gcgccttgta gggcgaaatc agaccgaagt
     6121 cgatgctctc gttcaggatg cgtgctttgc cgatccggtt gatataggct tccagttctt
     6181 gtagtaacag gttggcttcc tgcttgttga tgcgtccgaa gctctcgcct acaaactctt
     6241 cgtggaagtc catttccgag gtatctaccc agttcatggg agtgtcgaag tcaaggatac
     6301 cccggttgcg cacttccggt gcggcttcca gttcaccgtt gtagaaccat tcggagggaa
     6361 agcgcatgat tgcttcgtgc atccggtatt gcattttgag cagcgagacg gcagaaggtt
     6421 tttgctgcac gaccttttcc attaaagtgt ggtccagtcc gccacgggcg gcttcgatac
     6481 atttgattgt aggagggagc tggcaatggt cgccggcaag aatcacacgg tcggcctttc
     6541 ggatggcgat ccaacaagcg gcttcgagtg cctgggcggc ttcatcgata aataaggtgg
     6601 ggaaacgcct tccgttgagc aaacggtgat tgctgctgac cagcgtggaa gcaatcacac
     6661 gggcactgtc gaaaagatcg gcgttgatca ggatttccag ttcggtggca cggtcgcgga
     6721 ggcggctcat ccggctgcgc attccttccc tttcggagta acttccccga cgcatccggc
     6781 tgcccatttc acggatcgat tttcggattc cccaaagttc ggggtaggca ggatgattct
     6841 caaagcggcg ttcgtaagtg aaagaaagca ttttgtcatt aacacgtgta gggttaccaa
     6901 tgcggaggac aggcacaccc cggtctacca gtttctcgca aatccagtcc acagccgtat
     6961 tactttgggc gcagaccagc acctgcggtt cgcggtgaag cgtttcgtaa atggcttcca
     7021 cgagcgtggt agtctttccg gttcccggag ggccgtgaac gatggcgaca tcgcgtgtgc
     7081 ataacacttt gtttacggct gtttcctgcg tgctgttcag ccacgggaaa cggacgggat
     7141 ataattcgcg gaatcccggc ttttgtgttc ccagcaaggt gtcccggagt tcggcaaggc
     7201 ggttgccctt agcgcggatt gtgtcttcca gcgcttcgaa catggcacga taggacgttt
     7261 catcgaaata aagttgtaca cccagcacct cttccgtttg cagttccagc aaggcgcccg
     7321 cactgggaag cacgaccacc atccgttcgt cgtccgcata actcaccgtt gcaatgaaat
     7381 tcatgtaatt cacttttccg tcaaatgact gccggaaaaa gcagacggga cgaccgaatt
     7441 cgaaggaatg ctcgatttct ttattttcgg tgcgtgtaat atctattaca agttgattta
     7501 gagaattata gtaacttcga ccgggagagg cgggatacca gcacagacca cgtttcactt
     7561 tgcgggcgac acccattgtt tcagtctgcc gcttgaattc ctccttttcg tgttcatact
     7621 ccatgcgtag caggagttgc tgttgctgaa ggtcgatgat tggacttttc ggatgattat
     7681 tcataataga cgcaaaggta ataaatcttc ttcctgagac gaaaatatat ttcattttgt
     7741 taaacattcc tcgaacgccg ttcgttattt ttatagatag actaaaaaaa ataaaagcaa
     7801 tatggtgtat gatttgacta tgttagaggc tttttattct gcttataaag gaaaagtgga
     7861 acacgtgcgg gctgttttga aacgcccatt gacgttagcc gagaagattc tgtatgccca
     7921 tctgttcaat gagggcgatc tgaaaaacta caagcggggt gaagactacg taaatttccg
     7981 tcccgaccgc gtcgctatgc aggacgcgac tgcccagatg gcattgcttc aattcatgaa
     8041 tgcaggaaaa gaaaaagtgg ctgttccctc caccgtgcac tgtgaccact tgatacaagc
     8101 gtacaaagga gcaaaggagg acattgctac ggcaaccaaa acaaacgaag aagtttacga
     8161 ctttttgcgc gatgtatcct ctcgttacgg catcggcttc tggaagccgg gcgccggaat
     8221 cattcaccag gtagtgctcg aaaattacgc tttccccggc gggatgatgg taggaaccga
     8281 ctctcacact ccgaatgccg gaggactggg catggtggcc atcggcgtcg gcggtgcgga
     8341 tgccgtagac gtgatgacgg gtatggaatg ggaactgaaa atgccaagga ttatcggtgt
     8401 ccgcctgacc ggaaaactga gcggctggac ttccccgaaa gatgtgatcc tgaaacttgc
     8461 tgggattctg accgtaaaag gaggaacgaa ctccatcatc gaatatttcg gaccgggaac
     8521 agcttccctg tcggctaccg gcaaagcgac catttgcaat atgggtgcgg aagtaggagc
     8581 taccacttcg cttttcccgt tcgacgggcg catggctact tatctgagag ccaccggcag
     8641 ggatcgcatc gtggaactgg cggaagccgt ggactgtgag ctccgtgcgg accaacaggt
     8701 gacggacgaa ccggaaaagt actacgaccg tgtcatcgac attgacttgt ccacgctcga
     8761 accttatatc aacggccctt tcacaccgga tgccgctacc cctatctctg aatttgcaga
     8821 aaaagtatta ctgaacggct atccgcgtaa gatggaagtc ggactgatcg gttcgtgtac
     8881 caactcttct taccaagatc tcagccgtgc cgcatccctt gcaaggcagg tgaaggaaaa
     8941 gaatctgagt gtggcttccc cgctgattat caatccgggt tccgagcaaa tccgcgctac
     9001 tgccgaaaga gacggaatga tggatgactt catgcagatc ggcgccgtga tcatggcaaa
     9061 tgcctgcggt ccttgcatcg gtcagtggaa acgtcatacg gacgacccga cacggaagaa
     9121 ctcgatcgtc acatccttca accgtaactt tgccaaacgt gcggacggca atccgaacac
     9181 atacgccttt gttgcttctc ccgaactgac gatggcactg accattgccg gtgatctttg
     9241 cttcaatccg ctgaaagaca gactgatgaa ccatgacggc gagaaagtga aactggccga
     9301 acccgtagga gatgaactcc ccttgagagg tttcacctcc ggcaatgaag gctatatcac
     9361 ccccggcggg acgaaaacag cgatcaacgt caacccggct tctcaacgcc tgcaactgct
     9421 gactcctttc cccgcttggg acggacaaga tatactcaat atgcccctgc tgattaaggc
     9481 gcagggcaaa tgtactaccg accatatttc gatggcggga ccgtggctgc gtttccgcgg
     9541 acatttggag aatatttcgg ataatatgct aatgggagcc gtgaatgcgt tcaatggcga
     9601 aacgaacaac gtgtggaacc gttcgacaaa cacctacgga accgtttcgg gcacagccaa
     9661 aatgtataaa tccgaaggaa tcccctctat tgtcgtggcc gaagaaaact atggagaagg
     9721 ctccagtcgc gagcacgcgg caatggaacc ccgtttcctg aatgtgcgtg tgattctcgc
     9781 caagagcttc gcccgtatcc acgaaacgaa tctgaaaaag cagggcatgc ttgcccttac
     9841 ctttgcagac aaagcggatt atgacaagat acaggagcac gacctccttt cagtcatcgg
     9901 cttgccggac tttgctccgg gacggaatct gaccgtcgtt ctccatcacg aagacggaac
     9961 gaaagagagt tttgaagtgc aacatacata caacgaacag cagattgcct ggttccgtgc
    10021 cggctctgcc ttgaatgcca gataattaaa atgatagaaa tgaacaaaat aaccatgcaa
    10081 aaagatggta cgctatcggt gcccgatgtg cctgtcgtac cttatattac cggagacgga
    10141 gtaggagcgg aagtgactcc gtcgatgcag tccgttgtga acgcggctgt tcagaaagca
    10201 tacggcggca aacgtcggat tgaatggaaa gaagtgctgg cgggcgaacg cgctttcaac
    10261 gagacaggtt cgtggttgcc ggatgaaacg atgaaggctt tccaagaata tctgatcggc
    10321 atcaaggggc cgctgacgac ccctgtcggc ggtggaatcc gttctttgaa cgtggctttg
    10381 cgccaaactc tggatttgta tgtttgtctg cgtccggtcc gttggtatca aggcgttcat
    10441 tctccggtga aagcaccgga aaaagtgaac atgtgcgtgt tccgtgaaaa tacggaggat
    10501 atatatgcag gaatcgagtg ggaggcaggt actcccgaag ccgaaaagtt ctatcaattc
    10561 ctgaaaaacg agatgggagt gacgaaagtc cgcttccccg agacctcttc ttttggagtg
    10621 aaacctgttt cccgtgaggg cacggaacgt cttgtgcggg ctgcctgcca gtatgcgctc
    10681 gaccatcatc tgccttccgt gacactggtg cacaaaggaa acattatgaa gttcaccgaa
    10741 ggaggcttca agaaatgggg ctatgagctg gcgcaacgtg agttcggcga cgccttggca
    10801 gacggccggt tggtgataaa ggactgcatc gccgatgctt tcctgcaaaa tacattactg
    10861 attcccgaag aatattccgt gattgccacg ctgaacctga acggagacta cgtttccgac
    10921 cagttggcgg caatggtagg cggcatcggc attgctccgg gagcaaatat taactacaag
    10981 acggggcacg ccatttttga agcgactcat ggaaccgccc ccaacattgc cggaaaggat
    11041 gtcgtgaatc cttgttctat cattctttcg gcggtgatga tgcttgaata tctgggatgg
    11101 aaagaagcgg ccgcgcttat cgaaaaggcg ttggaacaga gtttcctcga tgcccgtgcc
    11161 acgcacgatc tggctcgctt tatgccggga ggtacatccc tgtctaccac cgctttcaca
    11221 cgcgaaattg tggaaagaat cgaaaagtaa atgtaacgat taaaaacgaa gtattatgaa
    11281 gaaagagtat ttgatttaca agctctccga ggagatgaaa gaggcaaccc ggattgacaa
    11341 tgaattgttc cccaagtttg acgtgaagcg tggactgcgt aatgaagacg gcaccggtgt
    11401 attggtaggt ctgacaaaga ttggtaatgt ggtaggttac gaacgtatcc ccggcggcgg
    11461 tctgaagcca attccgggaa aattgttcta tcggggctac gatgtggaag acatttccca
    11521 cgccatcatc aaggaaaaac gtttcggctt cgaagaagtg gcttatctgc tgctttccgg
    11581 tcgcctgccg gacaaggaag aactggcttc tttccgcgaa ctgatcaatg acaatatggc
    11641 gctcgaacag aagacgaaaa tgaatattat cgagctggag ggaaataata tcatgaatat
    11701 tctttcgcgc agcgtactcg aaatgtatcg tttcgatccc gatgccgacg atacttcccg
    11761 cgataatctg atgcgccaga gtatcgatct tatctccaag ttcccgacca tcattgcgta
    11821 tgcttataat atgctccgcc atgctacatt cggtcgttcc ctgcacatcc gtcatccgca
    11881 ggagaaactc tctattgccg agaatttcct ctatatgctc aaaaaagatt atacggaact
    11941 ggatgcccgt acgctcgact tgctattgat tttgcaggca gaacacggcg gtggtaacaa
    12001 ctcgactttc acggttcgtg tgacttcttc caccggaaca gatacatatt cggccatcgc
    12061 cgcaggtatc ggttcgttga aaggcccgct tcacggaggc gcgaatatcc aggtggccga
    12121 tatgttccat cacttgcagg agaatatcaa ggactggaag agcgtggacg agatagatac
    12181 ctatttcaca cgaatgctga ataaggaagt gtataataag accggattga tttacggtat
    12241 cggtcatgct gtttacacga tttccgatcc tcgtgcgctg ttgctgaaag aactggctcg
    12301 cgaccttgcc cgtgagaaag gaaaagaaga ggagttcgct ttcctcgaac tgcttgaaga
    12361 gcgtgccatc gctactttcg gacgtgtgaa gaacaacgga aagacggttt ccagcaatat
    12421 cgacttctat tcgggcttcg tatatgagat gattggtttg ccgcaggaga ttttcactcc
    12481 gctgtttgcc atggctcgta ttgtcggctg gtgtgcgcac cgcaatgagg aactgaactt
    12541 cgaaggcaaa cgcattatcc gtccggctta taaaaatgtt cttgatgatc tggcttatat
    12601 ccccatcaag aaacgctgat aagaacaaat ccttttatgc aataataact aacctcagac
    12661 gtacatctcg gtaatccctg catgtacgtc tcggtaatcc ccagttgtac atcttggtag
    12721 tacccggttg tacgtctggg gtgacttgtt tcaggaagaa catccgatgt tcatttaaca
    12781 tttaacactt tgcggttgct gtatttttca tccgatggag gctaaggcat ttatcgttgg
    12841 tagaaagggc acagcctggc aggtagaaac gcccttttaa cgctacgtta aaagggcgtt
    12901 tctacaaccg atgaattata cattctattt ctttggatat cagtgaacta tgatctttcc
    12961 ctttgctgga ggagagatta tggacaggtg acctgttgag aacaaacttg ttattttaat
    13021 aattaccgtc gattgcgtct ttgctgctat tattgggata aggtataatg tctattaaat
    13081 caaaatacat taagcgtgtt tttagatgcg ttccggtttc aaagcctgta tattccactt
    13141 cttgcgcttc cgtagagaaa aggtatttga aaccgttttt cagataatag ttcagaggaa
    13201 tattttcatt gtaagcgtca acaattaaaa agcgacaccc tgttttgttt cccgcatcaa
    13261 tgaaccatga ttttatgaaa gtcatcagat cactgcctat gccctgatgc ttgtattctt
    13321 tattgattcc aagtctgccg attaatacac ccggatagcg gtgcatttgt ttggctcggg
    13381 gaatgtcttt ctgaactttc ttttccctgc tgttggggag gatatttact ctgatactat
    13441 cgttagaaac agtgaaggca catactatgt ccgaaggctt tttatctgaa cgaaaacagt
    13501 aactttttcc taatagctgt gcattataga gaggagcatc gttatgaaag aagtcgtcta
    13561 agtcttggtg cccacatgag aaagggtcac attctttaat cgtatcttca tcaagtacgg
    13621 caaaagtaca tttctcaaaa agaaatccca tgttttataa cattttagcc tttttgagca
    13681 cagcacgggc ttccagcaca tgtttgctga agtcttgttt gttttgattt ttataagcct
    13741 tgtccgctgc cttaacgaag tgttccgctt cttttccttt taaggtcggt atggctttaa
    13801 tttccattgc cattgctttt tctattattt agttcataac caactgcaaa gatagctgat
    13861 ttttaatgaa taaacaaaga atgccggaag tctgttgtcg tttgatctgt tttttatttg
    13921 agttattttt gtgaccattc ttttcttttt ttgttatttt tgtgaatctc aaaagaaaat
    13981 caagatgagt atagctgcct ttaatctatt tttgggcgtc atgagtctga ccgctctgat
    14041 tgttttcatc gccctctact ttgtgaaagc cggttacggg atatttcgca ccgcctcctg
    14101 gggagttgcc atttccaaca agctggcgtg gatactgatg gaagcccccg tatttctggt
    14161 catgtgctgg atgtggatac actcggaacg tcgttttgat ccggtcatac tgacattctt
    14221 tgtcttcttt cagattcatt attttcagcg cgccttcgtc tttcccctgc tactgaccgg
    14281 aaagagtaaa atgccgctgg caatcatgtc gatgggaatc ctgttcaatc tattgaacgg
    14341 ctatatgcag ggtgaatgga tattttatct ctcacccgag ggaatgtatc attccggctg
    14401 gttcacttcc gcatggttta ttgcgggcag tctgcttttc tttgcgggca tgttgatgaa
    14461 ctggcattcg gactatatca tccgccattt gcgcaaaccg ggggataccc gtcattatct
    14521 gccacaaaaa gggatgtacc gctatgtcac ttccgccaat tatctgggcg aaatcattga
    14581 atgggcaggc tgggcaatac tgacttgttc actatccgga cttgtattct tctggtggac
    14641 agtggccaat ctcgtccccc gtgccaatgc aatctggcat cgctaccgtg aagaatttgg
    14701 ctcggaagta ggcgaacgca aacgtgtatt tccttttatc tattgatttg aaataaatta
    14761 tctattgaca taaaatagcg tactatggaa tctaaacttt tcacccctgt tactttcggt
    14821 ccattgacgc tgcggaatcg tacgatccgc tctgccgctt ttgaaagcat gtgtcccggt
    14881 aacgcccctt cacaaatgct gctcgattac caccgctcgg tggctgcggg cggagtcggg
    14941 atgacgactg tagcctatgc agccgtgaca caaagcggac tttccttcga ccgtcagttg
    15001 tggctgcgtc cggaaatcat ttccggtttg cgtgaagtga ccggagctat acacacggaa
    15061 ggtgcggcag caggcatcca gatagggcac tgcggaaata tgtcccataa aaagatttgc
    15121 ggaaccactc ccatttcagc ttctaccggt ttcaatctct attctcctac attcgtgcgt
    15181 ggcatgaaga gagaagagtt gccggagatg gccagagcct acggacgggc tgtccacttg
    15241 gcacgggaag ccg
//
