LOCUS       c00146_gnlPro..        16682 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LIPMHIIC_146.
ACCESSION   c00146_gnlPro..
VERSION     c00146_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:14:45
            Original ID  :: gnl|Prokka|LIPMHIIC_146
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16682
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16682
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3232:6790](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3233..6790
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16682
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16682
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(660..1814)
                     /locus_tag="ctg146_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1994..3199
                     /locus_tag="ctg146_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3233..6790
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg146_3"
                     /sec_met_domain="PFOR_II (E-value: 5e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6915..7103
                     /locus_tag="ctg146_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(7114..7974)
                     /locus_tag="ctg146_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(8002..8832)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg146_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8829..10055)
                     /locus_tag="ctg146_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10528..11814
                     /locus_tag="ctg146_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPIPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11777..12109)
                     /locus_tag="ctg146_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12137..14890)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg146_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15223..16449)
                     /locus_tag="ctg146_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGHRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 caggaataat aaataataaa gtaaacagct gccagggtta gtaatatttc tagtcaacac
       61 atagcagcta ttagagataa acaagtcaac cattattagg gaagtacaca gtattaccac
      121 aatatgactt ttccgatgtt caccaattcc aatttagcag tatcttcaaa gagtttccat
      181 tgcttgaaac cagagtttca tcggtgtgaa actgtagttt catcggtgag aaactagagt
      241 ttcatacgct tgaaacttta gttccaaacg ctcgaaacta tctgaaacta ctgttgattt
      301 gattgactta accgcatgtt ccaatcacat tgaacgcatc agctacttca atagtactgc
      361 tctctctgaa aacattaaat catatatcag tcaataatac ataaattatc agtccttaat
      421 acttgatttc tcaattatta atatctgaga aatcaaacgt taacagttga gatatcagat
      481 attaacatcc tgtaaatcaa agaataacac agtaaaaacg gtatttatca ggacgatgca
      541 gagtgagagc aagtccttgc tctcactctg ctaccactgg atctctaaca gctaaaacat
      601 cgatgaataa agggatacag acgaactgtt agagcatgag agcaaaagca ctatcttttt
      661 cactggggga gagtaagcaa aagaaacgca cgataccggc tttgaggcgt caccggtact
      721 aacggcaaat atccggcaca cacccgatta ttctctacgg acaaagggaa cgaagccgac
      781 atctgccgat gttcctccaa agcctgaccg gctaaaggat aataatcaat ccgaaaaact
      841 ccttccgcat ccgcagccaa ataacgatcc gtcaagagcc atgccaccac ccccatattc
      901 attcgcagat taatttcgac acaaggatga atccggtaaa caggcgcttc atccggaaaa
      961 tgacaaatca tcatatccac tcccaagtat ccatgataaa agccaccgaa caaagctgac
     1021 aattcttctt ccaaacgagt ccgcagcctg ataaattctt cttgtggcac ataagccgat
     1081 agtttctgca gaatcttctc gtcagacagc aagtcattcc ctgcatacat cccactccca
     1141 cccgtgtgga agaccgaata tccggcaaaa acaacccttc ctctcccgtc agcataaaac
     1201 tccatagcga aatcttccac cttattatat ataggttcgc ctaccacccc accctgagaa
     1261 gcagcgacac gggcacacca accggaaata aaagtagtaa atatgccttt acaccaattc
     1321 aatcctttcc cgcttccgga aagcggagct tttaacaagc acgcttcccg cccttcgacg
     1381 aacgcactgc actccgccaa agtactcaaa taaaaagatt ctccacagaa gtattcattc
     1441 aaccgcaacc caggcaacaa ctttaccgcc tgcagacgat gcgaatgctc tctcagaata
     1501 ttcatataat ccgcagaagg cagctccgtc tgatctgccc ccaatgtcat caaacgcttc
     1561 cgcaaagcag ggtcccaccc ccacggagag aacttccggt ctttaccgtc agccacttcc
     1621 ggttccgtca acaaggccac atccatgccc aaaagttcac tctttgtttt caggaagtcc
     1681 gcattataag cagacggtgc aagcaccgca cttcccgctt cggcatacca cataggaagc
     1741 aacgccaggt cactcgccat ctgtcgggcg gaagccggcg ccatatagtt cgtctcaccg
     1801 cttgccaacg ccatatcatg ctccggattg aatatataaa caggtctttt cgtcatgtca
     1861 aagatggatt caacacatta ttctgcaaat atatacagga aataatcagg aacttacaca
     1921 ataaagagaa acttataaat taaagcacat ttttgctatc tctactttgc aaatcctaaa
     1981 aaaagcacta tatttgccag ccgaaaaaca aagaaacgaa atggaatcat tctatcgcac
     2041 acacgcctac ctcgttgagc acaccaatgc ccccgttcgc cgcgatctta tggacgagat
     2101 cgactggagt gaccgtctga ttggtatcaa agggacacgt ggcgtaggaa aaaccacttt
     2161 cctcctgcag tacgccaaag agaaattcgg caccgaccgt tcctgtctgt tcatcaatat
     2221 gaacaacttt tatttctccg gtcacagcct tgttgacttc gccaacgagt ttcagaaacg
     2281 tggcggaaaa gtactgctga tcgaccaggt gttcaaacat cccgaatgga gcaaagagct
     2341 acgaatgtgc tatgaccgtt tccccagcct gaagattgtc ttcaccggtt cttccgtcat
     2401 gcgactcaaa gaggaaaacc tcgaattgcg tgacattgcg aaaagttata acctgcgcgg
     2461 attctctttc cgtgaatttc tgaacctgca gacaggaatg aaattccggg catacagcct
     2521 cgaagaaatc ctcagtacac atgaacagat agccaaagga gtactttcca aagtacgacc
     2581 gctggattat tttcaggatt acctgcatca tggtttctac cctttcttcc ttgaaaaacg
     2641 taatttctcg gagaatctgc tgaaaacaat gaacatgatg gtagaagtgg atatcttgct
     2701 gatcaaacaa attgagctga aatatctttc aaagataaaa aaattactat atttgttggc
     2761 tgtggacgga ccgaaagctc cgaacgtgag ccaactggca agtgacgtac agacatcccg
     2821 cgctacggta atgaactata tcaagtatct ggcagacgcg cgtctgatta atctggttta
     2881 cccgaaagga gaagaattcc caaagaaacc gtcaaagatt atgatgcaca actctaacct
     2941 gatgtactcc atttatccgg tgaaagtgga agaacaggat gtactcgaca cgttcttcgt
     3001 taacacttta tggaaagacc ataaggtaca taaaggagat aaaaacgtct ctttcatggt
     3061 agacgaagtg atgccgttca aaatttgtgc ggaaggtaca aaaataaaga ataacccgga
     3121 cgtgacgtat gcgttgcaaa aggctgagat aggccgcggc aaccaaatac ctctttggat
     3181 gttcggattc ttatactaaa aagatttatt tacttaaata tttaatttag ttatgactaa
     3241 acagaagaaa ttcatcacat gtgatggtaa ccaagctgca gcacatatct cgtatatgtt
     3301 ctctgaagta gcagctatct accccatcac tccttcttcg actatggctg agtacgtaga
     3361 cgaatgggct gccgcaggac gtaagaacat cttcggcgaa acagtattgg tacaggaaat
     3421 gcaatctgaa ggtggtgctg ccggtgcagt tcacggttct cttcaggctg gtgcattgac
     3481 tactacttac actgcttctc agggtcttct tttgatgatc cctaacatgt acaagattgc
     3541 cggtgaattc ttgccttgtg tattccacgt ttctgctcgt acactggctt ctcacgcatt
     3601 gtgtatcttc ggtgaccatc aggacgtaat gtcagctcgt caaaccggct tcgctatgtt
     3661 ggcagaaggt tctgtacagg aagttatgga tttggcaggt gttgctcatc tggctactat
     3721 caaatcacgc gttccgttca tgaacttctt cgatggtttc cgtacttctc acgaaatcca
     3781 gaagatcgaa atgttggaaa acgacgacct cgctccgctg atcgaccagg aagctttggc
     3841 tgaattccgt gcccgtgcac tgaatccgat gaagccggtt gcccgtggta tggctgaaaa
     3901 ccccgaccac ttcttccaac atcgtgaatc atgcaataac tactatgaag cagttcctgc
     3961 tatcgtagaa gaatacatga acgaaatttc caagatcaca ggccgcaaat acggtttgtt
     4021 cgattactac ggtgcagaag atgcagaacg cgtaattatc gcaatgggtt ctgtaactga
     4081 agctgcccgc gaagctatcg accacttggt agcaaacggc gaaaaagtag gtatggttgc
     4141 cgtacacttg tatcgtccgt tctctgctaa acacttcctg gctgctgtac ccaagactgc
     4201 aaagagcatc gcagtgcttg accgtacaaa agaaccgggt gctaacggcg aacctcttta
     4261 ccttgacgtt aaagactgct tctatggcgc agaaaatgct cctgttatcg ttggcggtcg
     4321 ctacggtctg ggttcaaaag atacaactcc ggcacagatc atctctgtat tcgaaaactt
     4381 ggctatgcca atgccgaaga accacttcac tatcggtatc gtagacgacg ttacgttcac
     4441 ttctcttcct cagaaagaag aaatcgctct gggcggtgaa ggtatgttcg aagctaaatt
     4501 ctacggtctg ggtgctgacg gtactgtagg tgccaacaag aactctgtta agattatcgg
     4561 tgacaacacc gacaaacact gtcaggctta tttctcttac gactccaaga agtcgggtgg
     4621 tttcacttgt tctcacttgc gtttcggtga tactccgatc cgttctactt acttggtaaa
     4681 tactccgaac ttcgttgctt gtcacgttca ggcttacctg cacatgtacg acgtaacacg
     4741 tggtttgcgt aagaacggtt ctttcttgct gaataccatc tgggaaggcg aagaactggc
     4801 taagaacctg cctaacaagg tgaagaaata ctttgcacag aacaacatct ctgtatacta
     4861 tatcaacgca actcagattg caatggaaat tggtttgggc aaccgtacca atacaatcct
     4921 tcagtctgca ttcttccgta tcacaggcgt aatccctgta gatcaagctg ttgaacagat
     4981 gaagaaattc atcgttaagt cttacggcaa gaagggtgaa gacgttgtta acaagaacta
     5041 cgctgctgta gaccgcggtg gtgaatacaa gactctgact gtcgatcctg cttgggctaa
     5101 cctgccggat gatgcaaaag cagaaaacaa tgatcctgct ttcatcaacg aagtagttcg
     5161 tccgatcaat gcacaggacg gtgacttgct gccggtatct gcattcaagg gtatcgaaga
     5221 cggtacttgg tatcaaggta cttccaaata cgaaaaacgt ggtgtagctg cattcgttcc
     5281 cgaatggaat gctgaaaact gtattcagtg taacaagtgt gcttacgttt gtcctcacgc
     5341 ttctatccgt ccgttcgtac tcgatgctga agagcagaag ggtgctaagt tcgagcaact
     5401 gaaagctgta ggtaaagcat tcgatggtat gacattccgt attcaggtag acgttctcga
     5461 ttgtctgggt tgcggtaact gtgccgacat ctgtccgggt aatccgaaga agggtggcaa
     5521 ggcattgacc atgaaacacc ttgaaagcca gttggccgaa gctgataact ggacttactg
     5581 cgctgaaaac gtgaagagca aacaacacct ggtagacatc aaggctaacg tgaagaactc
     5641 tcagttcgca actccgttgt tcgagttctc aggcgcttgc tccggttgtg gtgaaactcc
     5701 gtacgtgaaa ctgatttctc agttgttcgg tgaccgtgaa atggttgcta acgctacagg
     5761 atgttcttct atctactccg gttcagttcc ttctactccg tacactatga acgaaaaggg
     5821 tcacggtcct gcatgggcta actccttgtt cgaagacttc tgtgaatttg gtctgggtat
     5881 ggaactggct aacgaaaaga tgcgtgcccg tctggtgaaa gtaatgaacg aagctatcgc
     5941 ttctgattgc tgcccggctg aatacaaaga agtatttgct gaatggatca acaatatgct
     6001 ggatgcagaa aagactaagg aactggccga aaagatcatt ccgatggtag aagctgctaa
     6061 agataaatgc aaccactgca agcaaatcgc tgatctgcaa caatatcttg ttaaacgcag
     6121 ccaatggatc atcggtggtg acggtgcttc ttatgatatc ggttacggtg gtcttgacca
     6181 tgtaatcgct tccggtaagg acgttaacat ccttgtattg gatactgagg tttactctaa
     6241 cacaggtggt cagtcttcta aagctactcc ggtaggcgct atcgctaagt ttgctgctgc
     6301 aggtaagcgt gtacgtaaga aagacctcgg tctgatggct actacttacg gttatgtata
     6361 tgttgctcag attgctatgg gtgctgacca ggctcagact ctgaaagcta tccgtgaagc
     6421 tgaagcatat ccgggaccat cactgatcat cgcttacgct ccatgtatca accacggtct
     6481 gaaagccggt atgggtaaga gccaggaaga agaagaaaag gctgttaagt gcggttactg
     6541 gcacttgtgg cgttacaacc ctgctttgga agaagaaggc aagaatccgt tccaactgga
     6601 tagcaaagaa cctaactggg aagacttcca aggtttcttg aagggtgaag ttcgttacgc
     6661 ttctgtaatg aaacaatatc ctgctgaagc tgaagaactg tttaaagctg ctgaagaaaa
     6721 cgctaaatgg cgttacaaca gctacaaacg tcttgccaga gaaaactggg gagctgatac
     6781 agctgaataa taagtagaaa tactttgtac ataataaaag gcaggaatcc tggaaacaga
     6841 ttcctgcctt ttttgtttat atcttagaag taacgattac ttctcacgaa gatattcatt
     6901 aaaactctaa agatatgatc ggatttgtta tttggattat cggtttgata ctgactttca
     6961 gagctgccat agagatttgg aatataaatg cggctgtaga gaaaagactt atagcgattg
     7021 tattaatcgt tcttaccagc tggctgggac tacttttcta ctacttctat ggtaaagaaa
     7081 gaatggcggg atggttgaag tagtgtttgc atatcaatct ttctcaggaa tccaactgtt
     7141 caccagttcc tgatgttctt ccatccattg acgggcagcc tgtctttccg ttgtctgcgc
     7201 ctcttccaga gcagtcatta aggagctgat ttccgcatct gtcagacgaa tgttgcccaa
     7261 aagttcggca gcaaaagggt ctttctcgct aaaacctttc catgctatgg tatgaatgga
     7321 ttccgtattt ccatatatca gcttcgggtc ctgaagaact ttcagcttga aacggtcgaa
     7381 catccagtga ggcgtccatc ccgtcacgac aatccagtct ttcttatcaa tcgctttctt
     7441 tagggaagca gtcatggcag gtccgctcga agtcatcagt ttataatcca atccatagtc
     7501 tttgatggcc tgatcggtag ctttcataat accggctccg gcatcaatac cgacaatctg
     7561 accggagaaa cgttcctttt ccgcgttcag ttcttcgatt gagttgatcg taacgtaatc
     7621 cggaaccacc agcccgatac gggcaccatc ataaatatcc ccgataactt cgagtttatc
     7681 cccgtattgt ttcatataat cttccatagt gacaggcatc cagacatcca taaatacgtc
     7741 tgctttctta cgggagatag aggtaaatat aggtgcaagg tcggcattca gcaactttac
     7801 atcgtacccc tgatcttcaa aaatcgcttt ggcaaggttt gtcattgcaa taccttccga
     7861 ccagttggca taagcgatac ttatcttctt actctttccg ttgtctccgc aggaaacgaa
     7921 ggttaagagt atgccggcaa taaacattgc cgcaatcatt tttatcttat tcattgatta
     7981 ttcctttctt tggtgtgatt cttatttctt tttacttttt ctgttatctg ccataccctg
     8041 agtgatgcgg tccagcacga tcgccaatat cacgactgcg ataccgcctt caaatccgag
     8101 tccgattttc atttgggtga tacctttcag cacgatttct cccaatcctc cggcagaaat
     8161 catggcagca atcactacca tcgaaagtga catcatgatc gtctggttga ttcccgtcag
     8221 aatagtaggc aacgccaaag gcaattgcac cttataaaga agctgccagg gagtagctcc
     8281 aaaagagcgg gaggcttcta ctacgttttt aggaacctga cgaatgccca gaccggtcag
     8341 acgaaccaca ggaggcattg caaagatgat ggtggcaaaa gctcccggca cagttcccaa
     8401 tccgaagaat agaacggcag gaatcagata gacaaaggca ggcattgtct gcataaagtc
     8461 gaggacaggg cgcattatct tgttacaacg atcactgttg gcagtccaga ttcccaacgg
     8521 aacgcctaaa agcaatgcca gacaagtgga agaaagtacc aatgccaatg tctgcatcgt
     8581 ttcttcccaa aagcccatgc cgtaaataag caataaaccc aagagggtaa atacggctgt
     8641 ccccttaccc gacttaaacc aggcgagcgc agccagcact gcaattgtga tataaaaagg
     8701 tattccaaac agtacgtgct gaaaaccgtc tatgaatcct ccgatcccca tgctgagagc
     8761 atcaaaaaag gaagcaaaat gttctgtgag ccaattaatg gcagtctcta tatattgtcc
     8821 gatatttatc ataattctat tgcgttttga atgatttcat taatttcttc tttatctttt
     8881 cccgttactt cgatgatcaa tgaggaaagt ggcactacgc cttcaaactc ccgattctca
     8941 tttacgaccc agattggcga gttcgttttt gtcatcaacg gaagaatatc ttccagcact
     9001 gtatcaccca gcactgaatg aacttcatgc cttactacgg actcgatgga gcggatttgc
     9061 tcttttcgta gtttcagcaa gtcattcaac cgcacctctc ctactaacag attattggaa
     9121 tcgactaccg gaagaacggt cagattccgt tcgcgcatct tacggatcag cacctccggg
     9181 ccttctttct tcaaacgtgc cactatgggt ttatctacca taacagagga agctgttata
     9241 atcttgcttc gatctacatt ctccacaaat cgttctacat aagcgttggc aggttcggtc
     9301 aggatttctt ccgatgtacc gatttgtaca atttctccat ccttcatgat agcaatccgg
     9361 tcacccaatt taatcgcttc actcaggtcg tgagtaataa agacaatcgt ttttttcatc
     9421 ttcgactgca aagtcagcag ttcatcctgc atctgcacac ggatcaaagg atcgagtgcc
     9481 gagaaggcct catccatcaa caggacttcg ggattattgg ccaaagcccg cgccagcccg
     9541 acacgctgct gcatcccacc cgacagttca cttaccatct gattctcgta gcctttcagc
     9601 cccaccagtt gcatactttc catcgctttc tgctcccgtt ctcccttttt tactccctgt
     9661 agttcgagcc cgaaagctat attatgcaag acagaacggt gaggaagcag accgaagttc
     9721 tgaaagacca tagccagttc tttccggcga atctgcaaca gttccttatc cgacactttg
     9781 gctatgtctg ttccattgat aatcacttct ccggaagtag ggcgtatcaa acggttgatg
     9841 cagcggagta aagtggactt tccactaccg gacagcccca taatgacgaa tatttcgcct
     9901 tcattaatgg aaagattcgc atctttcacc gcaactgtac atccggtcgc tttcaatatt
     9961 tcactttttg ttttaccttc tttcaacatc ttcaaagcct tctgcttctc attgccaaaa
    10021 accagataga gatctttaat ttctatttta ctcatacaat aaaatggttt aggttattaa
    10081 aataatatac acagcaagac aagaacaaac gataacagga atctttcttt atatcgtata
    10141 aagttctgat ttaaataagg gacaaataac aatgaatccc gaaataatta ataaaatgat
    10201 tattgacaga ctgagtaatt aaaaaaggaa tagaatttga taagataatc ctttcaacga
    10261 atagcaaaaa atagcatttt tatgtataaa aacagcctgt tccagtatct tgctggcaca
    10321 aagatacaaa aaacggatta aacatacaaa ttatattcaa aatccggggc atacagaggg
    10381 ctttatttgt aatgatatgg aaagtttccg ggtaatattc ccctatcact cagcaaaata
    10441 gaacaaaccg gcagataaat ataaaataag tttgaatatt tcacttaaac accgtatatt
    10501 tggcgtcaat aactaaacta gatttatatg ttcaacaggg ctattacaat tttcctgggg
    10561 aaggataatt gtcattacac aacaaaagaa aaacaaacag gtactgccac actagacgac
    10621 aaaagccaag tacagttcct tagtaaaaag aaccccaaaa tgccgttttt ctatagccgg
    10681 cggaatctct acatgatagg tttcctgctc gcttttatag tgactctgct cgaatttata
    10741 cgaggacggc atcaaaactt tatggtcttc tcggacgcta ctcaattctt ctggcaaggc
    10801 atcagcccat acacaactga atttgtagaa gctcacggac gctacttcct ttattctcca
    10861 gttttcacgg tattgttcgc tccgtttgcg tatctgcctg catggctggg acctttcgcg
    10921 tggaatctat tcaattattc gctgttcttt atggcgatct tcacgctgcc ccaacaattc
    10981 acccagcagc agaaatgccg tatgttcctt tttctgttac tgattttagg acaaagttta
    11041 ctttcatttc agtataacat aacggtagcc tatttattct tattcgccta tacgttattg
    11101 gaaaaagacc gtggatttct ggctgttctg ttaatcatga tttcgggatg taccaaagta
    11161 tatggaattt tcgaactggc attgttgctg tgctatcctc acgtatggcg taactttggc
    11221 tatgccgtta caatgggcat tgtattgctt gcattaccgt taatcaaaat agctcctgca
    11281 gatttgctcc cctattatga agaatggtgc catagtcttg ctgttcatca gtccgccgga
    11341 gcttatgatt catttttcta tgcccgcccc attgcagcat ggacattgcc acacttccgt
    11401 gcacttcaga taggaatgct cggcttgctg actctgctct ttttggggaa tttccgcaaa
    11461 tggtcgtctt ttgccttccg tgcccaggct ttgggcattc tcatgggctg ggtagtatta
    11521 ctgagtgact ccgccgagaa gcatacctat attatcgcat tggcaggttt catgctctgg
    11581 tattggagca gaccaacacg taccgcaaca gacaagattc tattttggtg ctgttttgtg
    11641 ctgttatgta tcgttcctat cgacatattc gtccctatac ccatcagaga tttcattacc
    11701 aggaccttat ggcttcatgt atgggttttc tttattgtat ggatacggat gatatggctt
    11761 accttccttg catccttcat tcatccacgt gccacaaatg ttctttcaga ttaacgcatc
    11821 cgttagcttt gaaagaaact tcttctgcca gcaagagttg tttttgttcc acccaaccgg
    11881 gcaccagcct tccggtggaa tttacaactc tatggcaggg aatggataat tcatccggca
    11941 cttctttcaa tgcacgtccc accatccgcg agcattgggg tgcccccaac agcaaagcaa
    12001 tacctccata agtagatact tttcccacag gtatctggga tacgacttcg tacacttcct
    12061 tccgaaagga ttcggaaaag ctctctttat ctactttata atctttcata tatccctctt
    12121 tacgatatca atgaaatcat cctttccttt tcaggaaatc tgtcgggctc tctccaaact
    12181 gctctttata gcacttggcg aaataagaag gtgaactgaa accgacttca taaccaatct
    12241 ccgctacggt catgtccgaa gaagcaagca aagaagctgc cttcttcaaa cgggcgatac
    12301 ggagcaattc attcggagag tagttagtca atgatttaat cttgcgataa agctgcacac
    12361 ggcttagtcc catgtctttg cccaagtcct ccacattcaa accggagtct cccattttct
    12421 cttcaatcaa tgacttgaat ctttctacaa aatccttgtc catatcgcag acatcttctt
    12481 ttgccaatgt ctgcccgtca ccaaagaact gtttcagacg acggtgagaa tcgatcagat
    12541 tgcggacacg tgccagcaac agctgtgaac tgaacggctt tgaaatataa gaatccgcac
    12601 caccgtcata tccctgaata cgctgttcgt ccagtgaaca cgctgtcagc agaataaccg
    12661 gaatatgaca ggtctgtaac tcacttttca gccggcggca acattcaatg ccatcaatgc
    12721 ccggcatcat cacatcagaa atgatcaggt ccggaacata cttcatagcc ttacggattc
    12781 cttcggagcc gtctgccgct tcaatcaccg tatagtctgt atgcaacaac gtatggacat
    12841 acgaacggat atcctcatta tcatcaataa tcagtacgga cggtttggaa gagtcatatc
    12901 ctttttccag ttcttcctct tccgccaata gaacatctgt tgtacgggaa tccgcagaaa
    12961 caagggtggt atccggttcg gcagcaacag cctcacaaga ctgtacaggc agttcaacgg
    13021 taaagaccgt gccctgtttc tcatcgctct ctacggagat cataccaccg tgcatttcta
    13081 cgaaggcttt taccaatgcc agtccgattc ccgaaccggt atggtgcata tcgatcttat
    13141 agaaacggtc gaatacattg cgaatatgtt cggcagaaat catagaaccg gtatttgcca
    13201 ccgtgaaacg tatccatcgc ttgtcctctt tactaaggga agacagacgg acggctattt
    13261 tcccgttttc cggtgtaaac ttaaaggcat tggacagaag attgaaataa atacgttcca
    13321 gcttctccat gtctgccagt gtatgataat ccgtatccgg catactatca aaagaaaaat
    13381 ggatatgctt cttacgggct gccgcctgaa aagactcatt ccatccttcg aaagaagaaa
    13441 ggacatccac cgtaaccgga gtatattcca tcttgccgtt ttcatattta cggaaatcca
    13501 gaatctgatt gaccagacgc agaagaatgt tcacattccg ctgaatcagc atgagcatcc
    13561 ggtgctgatc tccgctcagt gtcttgtccg ccaacaaatg ttctaccggg tcggcaacca
    13621 atgtcaacgg agtacggaag tcgtgagaaa tattggtgaa aaagaccagc ttggcatggg
    13681 tagcttcttc cagttgatga gagagctgta tcaattggtc acgctgttct tccagtttgt
    13741 cacgctgctc ttccaattgc tgcttctgct taaaaagctc tttattcaag cgattcttag
    13801 agcggagtga tttataaacg accaataata agccggctac caataaaagg ataatcagac
    13861 tgccgtataa aacgacctgt tgtgtagcta cctgagagag atagccaccg atacgtccgt
    13921 tgagcgtttc aatctttttg tcgagttcgg aaatgtgtgt ggtctgcaac tgcatgacgt
    13981 gtgcgttggt acggtccaca acagcggtat tcatcaccgt ttctttggga tagggtttct
    14041 tctccagaat gtccatagcc agttgcagta ccttatcgcc attggtcgga tagataaagg
    14101 tggcatccag cacactgtcc agtaccagtt ccagtccgtt tcccttaccc ggcaaggcat
    14161 ctatgccgac aaaaatcatt tccttctccc gccctgccat ctttgctgcc tgataggcac
    14221 ccggagcgat acggtcatta tgggcataca cagcatcaat cttaggatgc ctccgaagca
    14281 tactatccat ttctatctct gccggaccac gttcccacgc agcatccgct ttatcaatca
    14341 gctttatatc cgggaattta ctgatggcag ccataaatcc ctgatgccgt tccattgcag
    14401 gagtcgaacc gctcaatcct gtcagttcta ctatatttcc cttccctttc agactggagg
    14461 caatatagtt tcctaccgaa cgaccgattt cataattatc ggctccgata taggcagtat
    14521 atttatccga aagaatcttc cggtctacaa gaataacggg gatgcctttc tgataagctt
    14581 cttctacaat cggagtcata ggagcagctt cgttagcgga aataatcagc agatcgactc
    14641 cttcgtccat aaaataatgg acatcttccg cctgcttact gttatcatcc cctgccgaac
    14701 ggatttccac cgaaacacca ttataaaaca tcgcttcccg aagaatctca tcattcatct
    14761 tatgtcgcca tgaatcatcg ctgcattgag ccaccccaat acgaaaacgg ggtgtatcct
    14821 gccggcaagc cgtcatcccg attaaaccaa acagcaccag catccacttc agatatctca
    14881 tcgtcttcat ccatctcatc atttcatagt tctttctgta atccaattaa gaacaaaaat
    14941 aagaaataat actgtaaagt tctctaactt cagctattta ttattctaaa aagaaggaaa
    15001 gcagtcctct ttcagaccat cggaaagtat taacaaaagt ataaagcgta aaacaaacac
    15061 ttaatcaatg ttataaaaca tagcgtttta cttggataat ttgcagattt cacagaagtc
    15121 cgtatctttg cactgtgttt ttcatagtat tagatttaag gttaacaaag gttggagcaa
    15181 ggcgttgctc ctttttttat gctctgacct ttcatctacc ggttagtttt catcccattc
    15241 cttttccagt ttaccatcaa tagtgtagcg tttccatcgt cctacacggt gaccattctt
    15301 atattcccca cattcacgaa gctggtcatt ctttacataa cgagcttcga acggtccgtt
    15361 ctgccttccg ttcacatagg tagaagtttc ccaataatca aagcggttgc tcactatcag
    15421 ccgtcgttcc ttgccatgca atctgccggc ctgataggta gcttcatatc tcaattcacc
    15481 attttccaaa ttatattcac ggtataaacc gtctttacga tcgttcttca tataatattc
    15541 tttctgcctt accccacttc cgttggcaaa tgagacatgg agtccatctt cttttccatc
    15601 cagataggtt tcaatcatca gcgtatctcc gctttcagca aaagtagtcc aacgaccatt
    15661 cttctttcca ttcttataac tacccagtat acgtggcgag ccaaacgtaa acacggacga
    15721 atattcaccg tcctgaaaac cttcttcatt gaaataaacg gtctcataca aatcatatgt
    15781 acctttcaga aaagtatact gtttgcctac ctgcttcccg tccttgtaat tatgctcttt
    15841 ccgcaaagta ccgtcagatt cgtacgacag ttgcttcccg tgctctttcc ccatccggaa
    15901 gtttctttca ctttccactt ttccggtagt aaagtaactt ttgctcgtac cgtccagctt
    15961 accttcctta taggactttt cttctttcag cttaccgtca aacttggagt taatcttgaa
    16021 gaggccatcc ttccgccctt ctttataact tccttccgtt attaatatat tgtccacata
    16081 ttctttgtat ccgccatcat aaaaaccatc tttaaaagat gccagcacat aggcggaatg
    16141 ataaccatct atgatgcgat gttcgccatt caatgctttt tccgttttca gttcctgaaa
    16201 caacagtctg ccatcgccta cattaacaac agatacctga tcgatcttat attccttttg
    16261 cgcaaacaaa ggaagagcaa gatataaaaa caaaaatacg ttccagcttt ttgatctgag
    16321 gaagttcgaa atgtgtttca taaagtagtt ttctcttttt gatttattat ttaaaaacct
    16381 gccgcaaaga taggcaatcg gcttataaaa caaggcaaga aagaggggga caattagaaa
    16441 aaagaacatc tgttattatc attctaataa ttaacagatt aagtagtaaa tcaaaacaca
    16501 gggaaggggg acatttactg aaataagaaa cagaaaagaa gatgtgtcaa aagcaactaa
    16561 attcccctcc ttcaggaagg aggagagttt agttactttt gacttttgac acatttacat
    16621 ttgcagtatt aaatatcaca acaaaatata agtgtatatt tgaaaagtag agttgcagtg
    16681 aa
//
