LOCUS       gnlProkkaLDLFKFLK_1224 13125 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LDLFKFLK_1224.
ACCESSION   gnlProkkaLDLFKFLK_1224
VERSION     gnlProkkaLDLFKFLK_1224
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 15:05:17
            Original ID  :: gnl|Prokka|LDLFKFLK_1224
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13125
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13125
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3811:8125]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3812..8125
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13125
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13125
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..160
                     /locus_tag="ctg1224_1"
                     /transl_table=11
                     /translation="MNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLLKQQLSAVCHGM
                     QELCEIN"
     CDS             178..2589
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg1224_2"
                     /sec_met_domain="Poly_export (E-value: 1.8e-18, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2600..3748
                     /locus_tag="ctg1224_3"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3812..4531
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1224_4"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.8e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4552..5853
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1224_5"
                     /sec_met_domain="CTP_transf_like (E-value: 3.4e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.5e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.9e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5870..6994
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1224_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.8e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.6e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             7004..8125
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg1224_7_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1224_7"
                     /sec_met_domain="Aminotran_5 (E-value: 2.6e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        7094..8101
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1224_7_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg1224_7_Aminotran_5.1"
                     /locus_tag="ctg1224_7"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             8122..8265
                     /locus_tag="ctg1224_8"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8468..9952
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1224_9"
                     /sec_met_domain="Polysacc_synt (E-value: 2.3e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9906..11165
                     /locus_tag="ctg1224_10"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             11174..11923
                     /locus_tag="ctg1224_11"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11923..12963
                     /locus_tag="ctg1224_12"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 atataatgtg tcgatgtacg ccaatccgga agacgaagaa agaaaacagg ctgttttgac
       61 ccgttctctg tctcttctcg atgttcttcc cccttctctt cttaagcaac agttatctgc
      121 cgtctgtcat gggatgcagg aactgtgtga aatcaactga aactttttta tttgtcaatg
      181 aaaatacaac gactttttag cattctacta ttttgtttga tgctgggaag tggctcgctt
      241 atggctcagt ccatgagtga ctcacaggta ctggaatatg taaaagacgg catccgccaa
      301 ggcaaggaac agaagcagct tgcttccgaa ctagcccgta agggtgtaac caaagaacag
      361 gcaatgcgtg tgaagcagct atacgagcag cagaacaatg taaatacctc gaaatcaacg
      421 ggcacggaca tcaacgaatc ccgcctgcgt gaagagacta agaagaatac ttccgatatg
      481 ctggaggatc atccgactac tcaggacctt gcccgtggtg atcaggtctt cggacgtaac
      541 atcttcaata cccgcaacct gacgttcgag cctagtgtca accttgccac tcctgccaat
      601 taccgtcttg gtcccggtga tgaagtcatc attgatatct ggggtgcgag ccagaacacg
      661 atccgccagc aaatctctcc tgaaggtact atcaacattc agaagatcgg ccctgtcaac
      721 cttagcggta tgacagtctc tgccgccaat gactatctga agaacgccct gaataaaata
      781 tataacggtc tgaataatac taccgatcct acttccgaca tccgtctgac gttaggtaat
      841 atccgtacta ttcagattaa tgtgatggga gaagtcgtac agcccggtac ctacgccctt
      901 tcttccttct ctaccgtctt ccatgcgctt tatcgtgcag gcggtgtgag tgatatcggt
      961 agcctccgaa acgttcagtt ggtacgcaac ggaaagaata ttgccaccat cgacgtctac
     1021 gaattcatta tgaaaggcaa cacacaggat gacatccgcc tacaggaagg tgacgttgtg
     1081 attgttcctg cctatgatgt attggtaaag attagcggca aggtaaaacg tcctatgcgt
     1141 tttgaaatga agaaagacga gaaccttgct actctcatta aatatgccgg cggctttgaa
     1201 gctgatgcct acacccgttc attacgtgtt gtccgtcaga atggtgagga atacgaagtc
     1261 aacacagtca aagatataga ttacaacatt tataaaatgc gtaacggtga cgtagtaacc
     1321 gccgaagcca tccttaaccg cttcacaaac aaactggaaa tccgtggcgc tgtctatcgt
     1381 cccggtatct accagctcag cggtaaactg aacacgatcc gcgaacttgt ccatgaagct
     1441 cagggtctga ccggtgacgc tttcctgaat cgtgccgtcc tctatcgcca gcgtgaagac
     1501 ctgaccagtg aagttgttca gatagacatt aagtctatca tggacggcac ttccccaaac
     1561 cttgccctaa tgaagaatga catcctctac attccaagta tccatgacct ggaagaccgg
     1621 ggtaatgtca cagttcacgg tgaggttgcc caccctgatt cctatcctta tgcggataac
     1681 atgacacttg aggatctgat cattcaggcc ggtggcttga aagaagccgc ctctactgtc
     1741 cgtattgata tatcgagacg aatcaagaat cctcgtagta ctgcggataa tgatacgatt
     1801 ggtcagatgt ataccttctc tttaaaggat ggttttgtaa tagatggtca gcccggtttt
     1861 atccttgagc cttatgatca ggtttatgtc cgtcgcagtc cgggctatca ggcacaacag
     1921 aatgtagcca ttgaaggtga aatccttttc ggaggaaatt acgccatgac cagccgtgag
     1981 gaacgtcttt ccgatttagt gaataaagcc ggcggtccga ccaattatgc ctatctgcgt
     2041 ggtgcgaaac tgacccgtgt ggctaacgct agtgaaaaga aacgtatggg tgatgtaatt
     2101 cgccttatga gcaggcaatt gggcgaagcc atgattgact ctttgggtat tcgtgttgaa
     2161 gatactttta cggttggaat agatttggaa aaagccttga gcaatcctaa aagtaatgcc
     2221 gatcttgtct tacgtgaagg tgatgtgatc tccataccta agaatactaa tactgtaact
     2281 atcaatggtg ctgtcatggt tccgaatacg gtttcttata tgaagggaaa gaatgtggat
     2341 tattacctga atcaggccgg tggctgttct gataatgcaa ggaagagtaa gaagttcatt
     2401 gtttacatga atggtcaggt gacgaaggtt aagggtagtg gtaagaaaca gattgagccg
     2461 gggtgtgaga ttattgtgcc tggtaaggct aagaagaaag ggaacatagc taatatttta
     2521 ggttatgcta cttccttcag ttctttggga atgatgattg cttctattgc taatttgata
     2581 aagaaataaa tgacctatta tgattgaaaa gcaatcttat caagaaccgt tttctgaagt
     2641 ggataaaagg aaagatgatg aaatggaaat agacttgatg gctatttttt ataagattat
     2701 tactgttcgt ggagtactat gcaaagctgc tggagtggga gtaataattg ctatagtggt
     2761 ggcattgagc attcccaagc aatatacagt aaaggttacc ctttctcctg aaatgggtaa
     2821 tgcgaaggga agtaatggtt tagccggact tgctgcctcg tttttgggag atggggctct
     2881 aataggggaa agcacagatg ccttgaacgc ttctctttca gcagatattg tttcttcaac
     2941 tcctttttta ttggaacttt tagaaatgga agtctccgtt tctaaaaagg atgataaaat
     3001 gactttgggg tcttatctcg atgaagagtc atctccttgg tgggattatc ttataggttt
     3061 tccgggcata gtaataggag gagttaaatc attattcgga gaagatacgg ttcctgccag
     3121 tggagggcgg caaggaacta tcgaattgac gaaagaagta aatgagaaga ttaattttct
     3181 taaaaagaag attagtgcat ccattgataa gaaaaccgcc ataacgagca ttacggtcac
     3241 cttacaaaat ccgcagatca ctgcggttat agcagattct gtcgttcata aattacagga
     3301 atatattatt gggtatcgaa cttcaaaagt aaaagaagac tgtgcgtatt tggaacggtt
     3361 gtttaaagaa cgtcagcagg aatattatgc tgctcaaaga aaatatgcgg attatgtaga
     3421 cgcccatgat aatgtggttc ttcaaagtgt acgtgctgag caggagcgtt tacagaacga
     3481 catgagtttg gcttatcaga tatatagtca ggttgctaat cagttgcagg tatccagagc
     3541 caaagtacag gaggaaaagc cagtctttgc agtagttgag cctgccgttg tacctttgaa
     3601 accttcaggt atgggactca aaatttatat tttattattt gtgttcctgt ccgtatctgg
     3661 tactctcgtg tgggtgtttt ttggcaaaag tctgctggct agcttgagaa aagaactgaa
     3721 aaataaggag atagaacagg ataaatgatg ctaaaacgtc gtttacaaca ttcttacatc
     3781 aattaaattc acttactata ttattaaacg aatgatacgt acagctatga taatggctgc
     3841 gggcatggga acccgttttg gccaatatac agaattgata cctaaagggt tcgtcaaagt
     3901 gggaggtatt ccaatgatag ttcgttctat tgatactttg ttatcatgtg acattgagcg
     3961 aattgtaatc ggtacaggat ataaacaaga agtttatgaa gaattgaaga cagactatcc
     4021 tatgcttgaa acctgtttta gtcctcgtta tgctgaaaca aatagtatgt atactttata
     4081 taatacgcgg gagattctgg gcaatgatga ttttttattg ttagagtcag atttgatttt
     4141 tgagaaacaa gcaataatga gcttattgga gtgtcctgcg gcagatgcaa tgctaataac
     4201 tccagtgaca aagtttcaag atcagtatta tgtggaacat gatgataatt ttcgcctttc
     4261 ttcatgttct gtcaataaga ataaactaaa cgctaaaggc gaattggtcg gcatccataa
     4321 actatccggt tccttttaca aaataatgtg tgctgattat gcgagtattg ttgatgaaca
     4381 acccaatttg ggatatgagt atgaattact acgaatatct tgttctcaat ctcctgttta
     4441 tgtgcataaa gtagaagggc tgaaatggta tgaaatcgat gacatatcag atttggaata
     4501 tgcagagaaa tatattgttc cgtattgtta attaaaataa tatatcaaat tatgagtaag
     4561 acagtttata ttgggatgac tgcggatatt atgcatccag gacttatccg cattattaat
     4621 gaggctacta aatacggtga tgttataatt ggtcttctta cagataaagc tattgcggag
     4681 cataaacgcc ttccttatct gacctatgaa caacgaaaag aggtagttca gaatattaaa
     4741 ggcgtatgta aagttgttcc tcaagaagaa tggagctatg ttgagaatct caaacgcatt
     4801 aaacctgact atataattca tggtgacgac tggaaaaccg ggcctttacg tgaagaacgt
     4861 gtgcgcgtat ttgaagtgat gaatgaacag ggaggaaagg ttatcgaaat tccatatact
     4921 ttgggaatta attcatcttc tttggataaa gatattaagg ctataggtac aacccctgat
     4981 gtacgtttaa aatcacttcg tcgtttgata aatgccaaac ccgtagttcg tattttggaa
     5041 gctcatgatg gactatgtgg cttgataatt gaaaatcagg aaatattaaa aggggataag
     5101 agggaagtat ttgacggaat gtggtctagt agccttacgg attcaaccag taaaggtaaa
     5161 cctgatattg aggcggttga tttaactacc cgattgcaag atttgaataa tattctggag
     5221 tgtactacta aacctattat ttttgatgga gatacaggtg gtaaaattga acatttcgta
     5281 tttacagtac gcactttaga acgtcatgga atttcagcta taataattga agataaagtt
     5341 ggattaaaaa agaattcatt gtttggtaca gatgttattc aaactcaaga tacaatcgaa
     5401 ggtttctgta ataagatcaa agcaggaaag gcatctcaga ttactgatga ttttatgatt
     5461 atcgctcgta ttgagagcct tatagcggga aagccggtaa gtgatgcttt agagagagct
     5521 tttgcatatg tccaagcggg agcggacggt attatgatac atagcaaaaa taagtcgggt
     5581 gaagatataa aagaattttg tttggcgttt cgaaaacagt atgctcatgt acctatcgtg
     5641 gttgtgccta ctacatatga tcatatttat gagtctgaat tgtgtgattg gggtgtgaat
     5701 ataattattt atgctaatca tatgcttcgt gccgcttatc ctgctatgat gaatgtcgca
     5761 aagataatat tagagaatga acgtgcttta gaggtgcgcg aactgtgtat gcccataaaa
     5821 gaaatattgg aactgattcc aggtactaaa taaaaagagg aatatcatta tgttaagcgt
     5881 agaaaaagtt tatgaaacgt ttctgagtca tgacgttgat ttttttacag gagttccaga
     5941 ctcattacta aaaaatattt gtgcctatat cacagaccat acttcacgtg agaaacatat
     6001 catagctgct aatgaaggtg cggctgtagg aattgcttca ggttattata tggcatcagg
     6061 taaggttcct gtggtttata tgcaaaattc cggcttgggt aatactgtta atcctctgct
     6121 gtctcttgca gatgaacaag tatacagttt tccaatgctt ttgatgattg gctggcgtgg
     6181 tgaaccggga acaaaagatg aacctcagca taaaaaacag ggtgaggtaa ctttagattt
     6241 gttgaaagca atgcggattc cttatataat tcttgattca aatgagaatg atgcatttat
     6301 tcagctccat gatatcatac aatcagcaaa aactaagaat attcctcatg caataattat
     6361 tcggaaagat gtttttggca aatataaact tcaaaaagag ttcggatgta attatccttt
     6421 atctcgtgag gatgctttgc aaatagttgt ggattatctg cctgaaaatt cagtggtcgt
     6481 ttctactact ggcaagcttt ctcgtgagtt atttgaatat cgagaaatga aagagcaagg
     6541 tcatgaacat gattttctca cggtaggctc tatgggacat agttcatcaa tctctttggg
     6601 tattgctata gcaaagcaag atagacctgt ttattgcttg gatggtgatg gagcatttat
     6661 tatgcattta ggggcaatta gtaacattgg cgatttatct cctaaaaact attatcatat
     6721 tttgtttaac aatggtgctc acgagtctgt aggaggacag cctactttag gatttagttt
     6781 agatattccg gctattgtcc gggggagcgg atataagcat acttatactg tttgtacaaa
     6841 agttgaaatt gaagaagcaa tgaagcagct tccaaagtta tgtggtcctg ttttgttgga
     6901 aataaaggtt aaaatagatt ctcgggagaa tttgggacgt cccacgacta ctcctataga
     6961 gaataaggag cattttatgg attttttaaa ataaatatat tcgatgaaaa tagaaagaaa
     7021 aatattatta aatcctgggc ctgccactac tactgacagt gtaaaaatgg cacaagttgt
     7081 tccggatatt tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac ttcgggacga
     7141 tttggtcaga gttgctcatg ggaatttgga aaaacatacc gctgtattat tttgtggctc
     7201 aggaaccatc aatattgata tatgtctaaa ttctcttctt cctgaagaca aaagggtgct
     7261 tatagtgaat aatggggcat atagtacccg tgctgtagaa gtgtgtcaat attatggttt
     7321 gcctcatatt aatttggaat tttccgttta cgaacgtcct gatttatcgg tggtggaaaa
     7381 tgtgttgcaa gaaaatcctg atatagctat ggtttatact actcatcacg agacgggtac
     7441 aggaattctg aaccctattc gcgagatggg cgctatagct cataaatatc aggctaaatt
     7501 tgtcgtcgat actacttctt ctttgggcat gattcctttt gatatagaga aagataatgt
     7561 ggatttttgt atggcatctg ctcaaaaagg acttcaagcg atgacaggtc tttcttttat
     7621 tataggcaat gaggaacaga ttaagttttc aaaaaaatat cccaagcgtt cttactattg
     7681 taatctttat ttgcagtatg agaattttga gagaacaggt gaaatgcatt ttactccacc
     7741 ggtacaaact atttacgcca ctcgtcaggc attaaatgaa tattttgaag tgggtgaaga
     7801 agctaagttt gcccgtcaca aaagagtttt tgaggctatt cattcaggta taaatgaaat
     7861 tggtcttaaa agtgtaataa agcgtgaatg gcagtcagga ctggttgtct cagttcaata
     7921 cccagaagat cccaactggg attttgagaa aatacatgat tattgttatg agcgtggatt
     7981 tacgatttat ccaggtaaga tatcaactga ggatactttt agaatctgtg ctttaggaga
     8041 gatagaagta gatgatattg agaacttctt taaagtacta aaagctgcat taaatcatta
     8101 taacgtcaca ttaccgatgt catgattgca gaaatattat tgaagattcg tcatttttat
     8161 ttttcccttc gtggtataca cttccatccg gaaagtgtta tttctggagt gcctattcgt
     8221 agctttcgct tagtaggcaa atatggcaat attaatttga ggtgatgcat taggagttct
     8281 ttattcttat aaaaaggcat cggtagttat aggagataat gtttgtgtag ggtaatttgc
     8341 ttttagtggg agagaccata ttagaattgc ggtaaggggc gaagaagata ataaccaatt
     8401 agtgagaata ttggaaaaat ataattgata tcggtaaatg tagttgtttt tatactgtat
     8461 ttaagtaatg gaaaatctaa agcagaaaac tgtatcagga ataatgtgga gcgctataga
     8521 acgtttctct ttacaaggag tacagtttat aattcaaata atattagctc gtttgttact
     8581 accatcggat tatggtatga tcgggatgtt agctattttt cttcaagtcg ctcaagtatt
     8641 tatagatagc ggttttacaa atgctttaat ccagaaaaaa gatagaactg aagaggattt
     8701 tgccactgtc ttttatttta atattcttgt cgcagtatta ttctatggta tattgttttt
     8761 ttcggcttct ttgattgcag acttttataa tatgccgact ttagttcttg taattcgttt
     8821 tatagcattg tcgttgataa taaatgcttt atcggctatt cacagaacga aattaattat
     8881 ttctgtaaac tttaaaactc aatctaaaat ttcattaggt gcagctttta tatcaggcgt
     8941 gattggaata tggatggctt atgtcggttg cggggtttgg gctttagttt ggcaaactct
     9001 cttaaatagt ataattttga caattttgtt ttactgttta gttcattgga aacctttaca
     9061 tactttctcc aaaagttctt ttgaaagatt attcaatttc ggatctaaat tattgatctc
     9121 aagtcttatc aatacagtat atcgtaatct gtataccatt gtaataggaa aaaagttttc
     9181 tgttgtagag cttggttact atacaagagc agaacaattt gctatttttc cttccaataa
     9241 tttaaatgct ttagtttcta gagtagcgta tcctatttta agttccattc aagatgatga
     9301 taaatgttta acaaacgcat atcgaaatta tatcagatta tcctcatata taatttttcc
     9361 tttaatggta ggtttacttg ttttggctaa tcctattatt agtctattgt taacagataa
     9421 atggtctggg gttgttattc ttttacagat attatgtttg gattggatgt ttgatcattt
     9481 gagccaaatt aatttgaatt tattatgggt taaaggaaga tctgatctgt cgttacgtct
     9541 tgaaataata aaaaagacga ttgctatatt cattcttttt gtgtcaattc catttgggct
     9601 tgaggtgatg tgttggggta gagttattta ctctctgata gcgacatatt tgaatacata
     9661 ttatactaat tctcttattg atttgacctt aaagttgcaa gttaaagatg tatttccaag
     9721 tttaatactc tctttcataa tgggggggat cgtttttata tgtatttctt tctttgaaac
     9781 tgatatagta aaaattgtga ttggatgtat tactgggatg tccttctata ttttactttc
     9841 ttttcttttt aagctagatt cttttttttg tattttaaca ttgatcatta aaactaaaaa
     9901 catagatgaa aatattaaaa aagatttttc aagtaatagt aaagataatt aaccattgtg
     9961 tgccagttga tagtagatca ttgtatttta ttcctcatcc taattgtaga acagataaat
    10021 atgatattat aaattattcg tcagataatg ttctcgttct gttaaattat ttgctaaaaa
    10081 aagatagtgc tgaatattat aaaatatatg ttgaaattta tgattcttct cgtatttcag
    10141 aatatcaaga atatatttat ggcataaatc ctaatattag gtgtactttt ttatgtgcat
    10201 gtgttggacg ttttttcttt aataaagtat cttttaagga tatgttgtat gccttttttt
    10261 gtttttgtag agcaagtaaa tgttttacag ctacttttta ttatgatttt tcatttaaaa
    10321 aacgctctca acagattatt tgtttggggt attatactcc attcaaagat gattatcata
    10381 tgggagatca ttcttatgat aaatttcgta atacaacatg taactcattt gattactcta
    10441 ttgctacttc ttgtttaagt gctagaataa tttcaataga ttgtggaatc tcatatgata
    10501 aattcaaagt cttaggattt cccagaaatg atttgttgat atcgaaaaat aattgcaatg
    10561 ttattaaaag agaaatttcg aaatttgcgg gatatgatgt aactaaatat atagtttata
    10621 ctccaacttt tcgtgattat gagactgtta ctgaaggtaa tttgcgttca atactcggat
    10681 atgttgattg tgatttgttg aagttatcga aaatactatt gaagtttaat gcggctttaa
    10741 ttcttaaatt acatcctttg cagaataaaa cagtcttaaa aaaagattta cccaaaggta
    10801 tacttgtttt tgaacaaaca tataaatatg gattgtatga tcttttgtca ttttcagatg
    10861 gaatgattac tgattatact tctacctatt ttgatttttt attggtaaat aagccagtca
    10921 tatttaattt ctacgatatt gaagaatatc gtagagtaag aggtttctca tttgagccaa
    10981 tagaattttt ttgtgcaggt gatattgttt acaattataa tgaattgata gatgctgtga
    11041 tgggacttct ggctgggaaa gatattcatg ctgaacatcg acgtcatatt tctttattga
    11101 tgaatcaatt tcaagatgat aattcaacaa agagaatatg tgacatattt ttaaatgaaa
    11161 tataataaat aaaatgaatt atgcatttgt ggtgcaggca cgtttaggtt ctacacgttt
    11221 gcctggaaaa atattgaaac ctttctatgg taatcaatcg attcttgact taatggttca
    11281 taagctttct gctatatcga atattccagt aattattgct acaacaaatt ctgttatcaa
    11341 tgaacctatt gaaaagaagg cacttgcatt aggggtaaag tgcttcagag gtgaggagaa
    11401 tgatgtttta aaacgattca ttgatgttgc tgaatatttt gatatacagg gtatattccg
    11461 aatatgttct gataatccat ttttagatgt acatgcggca aggcaattgg tcgaaatagc
    11521 aatgaaatct tgtaacgatt atataagttt tgatattgat ggtactccat caattaaaac
    11581 tcatttcggt ttttggggag aatttgtaac gcttgatgcg ctgaagcgag ttataggatt
    11641 tactgatgat ttattgtatc gtgaacatgt tactaattat atatatagtc atcctgaact
    11701 ttttaatatt caatggattt caggatctcc agtcgtgtca aaacatcata atattcgact
    11761 cacgattgat acgttagaag atttttctgt agcacagaga atatataggg atttacaaga
    11821 aaaaagagtg gaaatatcga tagaagtgat tgtagactat gttcgaagac atgcagaata
    11881 cattcaactg atgaaacaac aaataaaaaa aaattctaaa taatgaagaa tacttatatt
    11941 attggtgaaa tagggcagaa tcataatggt tctgttgact tggctaagtt gattattgaa
    12001 ttaatctcac gacctgtaca tgaggatgtt tttggtatgg atttcatgcc aatgaatgct
    12061 gttaaaatga ctaaaagaga tttatcagaa gaattggctg tttctcaaat gaatcaaata
    12121 tatgacaatc ctaattcttt tgggcgtact tatggtgaac atcgtgcttt tcttgagctt
    12181 gatgatcaag cgcattttga gatttataaa tatgctaagt cattaggatt agattttatc
    12241 gagacgttat gtgccaaagg atgtctgtct ttgcttaaac tgttcacacc ggataggcta
    12301 aaagttgcta gtcgtgattt gactaactta ccattgcttg aagcattagc agaaactcat
    12361 attcctatta tattatcgac aggaatggct ggtcaaagag aacttgacaa tgcattagat
    12421 gtgataacga gatatcatag taatatagct attctacatt gtgtatctca gtatccaact
    12481 catccaaata atttgaatct acgtacaata acatatttga agaagcatta caataagttt
    12541 gagataggtt tttctgatca tacaataggt atttctgctg ctacagctgc tgtagcgatg
    12601 ggagcggaaa ttatagaaaa gcatgtaaca attgatcggc atatgaaagg aacagaccag
    12661 cttggctctt taggtccaga tggggttaat cgtatgattc gagatattcg catagcagag
    12721 tgttggcttg gtactgaaga tctttatata gaaaaagggg tggagaagtc taagataaaa
    12781 cttgaacgtt ctattgccac tcgaaaatat attccagcag gtagtattat tcaagagtcg
    12841 gacattcatt tactgagtcc tggtgatggt tataaatgga tagataaaaa aaatgtaatt
    12901 ggtcattttg ctaaacaaga tatatcagcg aatgaaataa tatatcctga ttttattgaa
    12961 tagatatatt cctactgcaa cttgtattac ggtatagagt actgcctgct ataagctaag
    13021 tagtgattaa taaataaggg taaaatacta aaaaaatgaa agagataaag cttatactta
    13081 cagatattga tggcgtttgg actgatggcg gaatgtttta tgatc
//
