LOCUS       c00048_gnlPro..        15063 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCBGJHOB_48.
ACCESSION   c00048_gnlPro..
VERSION     c00048_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:18:24
            Original ID  :: gnl|Prokka|KCBGJHOB_48
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15063
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15063
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8459:11485]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8460..11485
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15063
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15063
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             3..893
                     /locus_tag="ctg48_1"
                     /transl_table=11
                     /translation="TYMGFSDDEHNALADADLKKALEVTTNKSETQYNIAKLIYSYIIS
                     LGDKKPYGDWSYDKALSIIHDAMQADNQPIYTQLEGDILFAMKKYPEAYAAYEKVNQSS
                     IASAATFYSAAKTKQLIEGTDMNEVIALMDSAVARFTKPYTSEAAPYFYERAEIKAQTG
                     KYREAVIDYDTFYDAIGGRVTAAFYLQREQAEIQCKMYQQAINDINKAVEMTPEDVAMW
                     VEKGSVHLRVGQHNEAIEALEKAISLDPKAAAAYRMLGYCQIQLKKNKEACANFAKAKE
                     LGDEVVDGLIQKYCK"
     CDS             complement(1032..2336)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP_bind_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_2"
                     /sec_met_domain="ATP_bind_3 (E-value: 2.6e-52, bitscore:
                     167.0, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFHWNIQKYIEEKQLFTLHDKVLVALSGGADSVALLRVLLVLGYH
                     CEAAHCNFHLRGEESDRDERFVNELCKGLGVALHVTHFDTVTYASRHHVSIEMAAREMR
                     YDWFEQLRKERGGAVIAVAHHRDDSVETFLLNLIRGAGINGLKGISPHNGCIVRPLLEV
                     SRQDILDYLRCLRQGYVTDSTNLQDEYMRNKIRLNILPMLRELNPSVSESIAETSRRLT
                     DVSLIYNKEIEAGKERVMEKSGHILISRLMEESAPAALLFEILHPLGFNSVQAGDVFRS
                     LSAQSGKRFVSAGWEVLRDRTELIIRRRKLADEEVEENVPPFRLAMETQEIMPDFVIPK
                     NKDTACLDADKVVLPLTVRKWRQGDKFVPFGMKGKKKISDYLTDRKFSLFQKENQYVVC
                     SAGQIVWLVGERSDDRFRVTEDTKRVLIIQQLWDK"
     CDS             2457..4925
                     /locus_tag="ctg48_3"
                     /transl_table=11
                     /translation="MRLSELRTGEKGVIVKVLGHGGFRKRIVEMGFIKGKTVEVILNAP
                     LKDPIKYRLLGYEISLRRQEADMIEVVSEQEARTMQNPYHGSITEDVPVPESELVALAK
                     GKRRTINVALVGNPNCGKTSLFNIASGAHEHVGNYSGVTVDAKEGFFDFQGYHFRIVDL
                     PGTYSLSAYTPEELYVRKHIIEETPDVIINVVDSSNLERNFYLTTQLIDMNVRMVIALN
                     MYDELEASGNKLDYTQLSQLIGVPMVPTVCRRGEGVDKLFHVIIGIYEGGDFLSQKGEI
                     RSEILEDLRDWHKTYVPDHEFGSHKEEEDARPRGYMRHIHINHGPELERSIEEVKKAIS
                     QNEDIRHKYSTRFLSIKLLENDREIENFISTLPNGKEIIAIRNKETLRIRKVMNEDSEQ
                     AITDAKYGFITGALKETFTDNHLEKEQTTRVIDSIVTHRIWGYPIFFLFLYIMFEGTFV
                     LGDYPMQGIEWLVDQLGNLIRNNMAEGPLKDLLIDGIIGGVGGVIVFLPNILILYFFIS
                     ILEDSGYMARAAFIMDKIMHRMGLHGKSFIPLIMGFGCNVPAIMATRTIEDRKSRLITM
                     LVNPLMSCSARLPIYLVMIGAFFPNCASFMLLCIYTAGILLAVIMARIFSKFLVKGEDS
                     PFVMELPPYRMPTSKSIMRHTWEKGAQYLKKMGGIIMIASIIIWFLGYYPRHDTHESVA
                     EQQENSYIGQIGKAIEPVIKPLGFDWKLGIGLISGVGAKELVVSTLGVLYTNEGDVENV
                     NLSDRIPITPLVALAYMLFVLIYFPCIATFAAIKQESGSWKWAIFAAGYTTGLAWLVAF
                     TVFQIGSIII"
     CDS             5187..5381
                     /locus_tag="ctg48_4"
                     /transl_table=11
                     /translation="MSYLCNRNRETKIDNNKVPWMSGLVSGLQNRVRRFESARNLLITS
                     KINMQKGIIHRLFPFAYNI"
     CDS             complement(5490..6170)
                     /locus_tag="ctg48_5"
                     /transl_table=11
                     /translation="MKEYRLRVKEKIMKADLATIRREYTKGGLKRSDLPDNPLVLFTKW
                     LQEAIDAEVNEPTAMLVGTVSPEGKPAIRTVLLKDLHDGKFIFYTNYGSRKGKHLAHNP
                     SISISFVWHELERQIHIEGIAAKVSPQESDEYFRKRPYKSRIGARISPQSEPIESRIQL
                     IRDFVKETTRWIGKEIDRPEYWGGFAVMPVRVEFWQGRVNRLHDRFLYMLQSDGVWKIE
                     RLAP"
     CDS             6596..7690
                     /locus_tag="ctg48_6"
                     /transl_table=11
                     /translation="MKILLIGEYSNIHWTLAKALRNMGHRVDVLSHSNLWLNNSDYLYP
                     NRSSIRWGVLKNTFNLLKTLPQLRGYDVVQLVNPYFLELKPELLQYVFQYLKKNNKKIF
                     LGGFEYDFYWIYMCLNKNALRYNDFYANGTFRDTIDNKMAIINWMHGFRGKLNRIIANN
                     CNGIITSLYESYLAYQPYFSGKTKYIPFPIESLPHPQIPFKKIEKVKFYISLKHHREEW
                     KGKDELYSALYKLYYRHPSACEIKQTVFTPYDECEHFMDGCDVMLDQLYSYSPGLNALY
                     AMSKGIVVVGGAEEEHYNLLGEDRLRPIINVRPEGNDIYNKLESLLANTNKISQLSADS
                     IEYIKKHHCPIKVAKECLDFWEKN"
     CDS             7663..7854
                     /locus_tag="ctg48_7"
                     /transl_table=11
                     /translation="MFGFLGEKLIPPINTSLSAPYYFHQKIYLKKRAKGLHISIYPLIF
                     VLRLRDNASDKKEVWVSG"
     CDS             8460..10688
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_8"
                     /sec_met_domain="Gly_radical (E-value: 8.7e-48, bitscore:
                     151.2, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1171.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMNKVFKDGLWSKEINVSDFVHTNITPYEGDASFLAGPTERTKK
                     VWNECLKALEEERANNGVRSLDNVTVSTITSHKAGYIDRENELIVGLQTDELLRRAIKP
                     YGGIKVVEKACHENGVEVDEKVKDIFTHYRKTHNDGVFDAYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGIDRLIEAKQEDLHNITSPMTDARIRLREEVAEQIKALKEIK
                     ILGEYYGLDLGRPATNAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYIQYDLDH
                     GKIDESFAQELVDQFIIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKEFCAQVSIDTSSIQYENDTLMREVRNC
                     DDYGIACCVSYQAIGKQIQFFGARCNLAKALLLAINGGRCENTGTVMVKDIPVLTGDLL
                     NFEEVWSNYKKVLMQIARVYNDAMNIIHYMHDKYYYEKAQMAFIDTDPRINLAYGVAGL
                     SIAIDSLSAIKYGKVRAKRNDIGLTEGFDIENAYPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKHPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDAQDGISNTFSIVPKSLGVDQETRIENLVTMMDGYFTKGAHHLNVNVLN
                     REMLEDAMEHPEKYPQLTIRVSGYAVNFIKLSREHQLEVISRSFHERM"
     CDS             10757..11485
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 77.8;
                     E-value: 3.2e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_9"
                     /sec_met_domain="Radical_SAM (E-value: 2.4e-28, bitscore:
                     89.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIDTKGE
                     STETTIDEIVRMAVSQKAFFGKKGGVTFSGGEPTLQAKALIPLFQRLKEQSIHICIDTN
                     GSIWNEEVKELLQWTDLVLLDIKEFNNVRHRQLTERSNEQTIRTAGWLEKNGKPFWLRY
                     VLVPGYSSFEEDIRALGEHFKNYQMIQRVEILPYHTLGVHKYEAMGKEYKLNGIKENTL
                     KQLETAKTLFGEYFNTVYLN"
     CDS             11587..12336
                     /locus_tag="ctg48_10"
                     /transl_table=11
                     /translation="MKRLLLLCLTYIMCVGNHQMAAQDSSESPGIFNSLAVGVSASTTG
                     IGIDVASPIGSYLAVRAGVSFMPNFTYSTDVDVDIEGSYEGNIPTSIDVEGGMGRTAGE
                     ILLNVYPFKSSSFFVCGGAYFGGGKLIKIKGHSDELAELIKEGQEVGIEIGNYRIPVDQ
                     NGNISGGLKVSSFRPYLGLGFGRAIPKKRIGFMFEMGVQFHNTPKVYTNNGDLSDLTAE
                     ADNDFTDIIDKLTVYPVLKFRLCGKIF"
     CDS             complement(12415..13002)
                     /locus_tag="ctg48_11"
                     /transl_table=11
                     /translation="MSSREDILQSIRRATHVKYEKPDLKPLEDMALTYPSKVEQFYLIM
                     KQVGGEAILLEKEEDVNDFIKKAYPGAKRIASNLKTITCATFNPDDVEDPAELNGTDLA
                     VIDGKIGVAENGAVWIEQDVKQRAIYFIAEKLVILLNKNKIVNNMHEAYKLIDTGEYGF
                     GTFISGPSKTADIEQALVMGAHGARDVMVVLI"
     CDS             complement(13005..14372)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_12"
                     /sec_met_domain="Fer4_8 (E-value: 1.9e-12, bitscore: 37.4,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.9e-06, bitscore: 16.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTKHSKAAAEFLKNKKQAAWHDETLWLVRAKRDRLSKEVPEWEE
                     LRNMACATKLYSNSHLDELLVEFENNARANGAHVYWAKDADEYCNIVYNILNQHGVKHF
                     IKSKSMLAEECELNPFLENKGIEVVESDLGERILQLMHLKPSHIVLPAIHIKREQVGEL
                     FEREMGTEKGNFDPTYLTHAARKNLRQKFIHAEAAMTGANFAVASTGEIVVCTNEGNAD
                     MGTSQPKLQIAAFGMEKIVPDRESLGVFTRLLARSATGQPITTYTSHYRKPREGGELHI
                     IIVDNGRSKILADQKHIKTLNCIRCGACMNTCPVYRRSGGYSYTYFIPGPIGINLGMLK
                     APLHYYDNVSACSLCYSCSFVCPAKVDLAEQIYLWRQDLDKLGKADRMKRVMSGGMEFM
                     MNRPLIFNMALKWAPLVNGMPRFLIYNGLNDWGKGREMPKFAKESFNEMWKKGKVK"
     CDS             complement(14369..15061)
                     /locus_tag="ctg48_13"
                     /transl_table=11
                     /translation="QVGIASYKLLKSLGVDVDYPLNQTCCGQPMANAGFENKAVDLARH
                     FDEQFKNYDYIVGPSASCVVFVRDNYSRLLKEDKHRCASGGKIYDICEFIHDIVRPSSL
                     KAKFPHKVSLQNSCHGVRLMKLSSASELNIPYFSKLRDLLSLVEGVEVVEPERKDECCG
                     FGGMFAVEEDAVSVQMGHDKVMRHIATGAEYIVGADSSCLMHQNGIIARDKLPIKTLHI
                     VEILAAGL"
ORIGIN
        1 ctacttatat gggatttagt gatgatgaac acaacgcttt ggcagatgct gacctgaaga
       61 aagcactgga agtgactacc aacaagagtg agacgcaata taatatcgct aaattaattt
      121 attcgtatat catctcttta ggtgacaaga aaccatacgg tgactggagt tacgacaaag
      181 ctctctccat cattcatgat gccatgcaag ccgacaacca acccatttac acacaattgg
      241 agggagatat tctgtttgct atgaagaaat atcctgaggc atacgccgct tatgagaaag
      301 tgaaccagtc ttccatagcc tctgccgcta cattttactc ggcagccaaa accaaacaac
      361 tgattgaagg aacagatatg aacgaggtta ttgccttgat ggatagtgct gtggcacgtt
      421 tcaccaagcc ttatacatcg gaagctgctc cttatttcta tgaacgggca gaaataaaag
      481 cccagacagg taaataccgt gaagcggtaa tagattatga tactttttat gatgctatcg
      541 gtggacgggt tacagccgcc ttttatctgc aacgcgaaca ggcggaaata caatgtaaga
      601 tgtatcagca agctatcaat gacattaata aagcagtaga aatgactcct gaggatgtag
      661 ccatgtgggt ggaaaaaggt tcggtgcatc tacgtgtagg gcaacataac gaagcaatag
      721 aagcattgga aaaggctatc tctttagacc cgaaagccgc agccgcatac cgcatgctgg
      781 gatactgcca gatacaatta aagaaaaaca aagaagcctg tgcaaacttt gccaaagcaa
      841 aagaactggg cgatgaagtg gtagacggac tgatacagaa gtattgcaaa taataccgga
      901 aagctccatc caaaatccgc gaatcttgct acgtgatttc tgaaatcttg ttgcatgatt
      961 cgcggatttt tgctacaaga tttcagggag cattccctgc cattcatgaa aaagcaggaa
     1021 aggaaaaaat tctacttatc ccacaactgc tgtataatca gtacccgttt cgtatcttcc
     1081 gtcacccgga aacggtcatc gctacgctct cctaccagcc atacaatctg gcctgcagag
     1141 caaaccacat attgattttc tttctggaaa agagaaaact tacgatctgt cagataatcg
     1201 ctgatcttct ttttcccttt cattccgaaa ggaacaaatt tatccccctg ccgccattta
     1261 cgcaccgtga gaggtagcac caccttgtct gcatccaaac aggccgtatc cttattctta
     1321 gggatgacaa agtctggcat tatttcctgc gtttccattg caagccggaa cgggggcaca
     1381 ttttcctcca cttcctcatc cgccagcttc ctcctgcgaa taatcaactc cgtcctgtcg
     1441 cgcagtacct cccatccggc agaaacaaac ctttttcccg actgggcaga caaactgcgg
     1501 aatacatctc ctgcctggac agaattgaaa cctaacggat gaagaatctc aaacagcaaa
     1561 gccgccggag cactctcttc catcaaacga gaaataagaa tatgaccgga cttttccatc
     1621 accctttctt ttcctgcctc tatctcctta ttatatataa gagaaacatc agtcagacgc
     1681 cttgatgttt cagctatact ttcactgaca gaaggattca gctcacgcaa catcggaaga
     1741 atattcagac ggattttatt acgcatatat tcatcttgca aattggtact gtctgtaaca
     1801 taaccttgac gcaaacaacg caaataatcc aaaatatcct gacggctcac ctccaacaaa
     1861 ggccgtacaa tgcagccgtt atgcggacta atacctttca agccattgat tcccgcgcca
     1921 cgtatcaaat tcaataaaaa agtttccaca ctatcgtccc ggtgatgggc tacggcaata
     1981 acagcccccc ccctctcctt acgcagttgt tcgaaccaat catagcgcat ttcgcgagcc
     2041 gccatctcaa tagaaacatg atgcctcgaa gcataagtga ccgtatcaaa atgagtaaca
     2101 tgcaaagcca ctcctaatcc tttacacaac tcattgacaa acctttcatc tctatcggat
     2161 tcctcaccac gaaggtgaaa attacaatgg gcagcctcac aatgataccc taaaacaagc
     2221 aagacacgca acaaagctac cgaatctgcc ccgccactca atgccactaa caccttatca
     2281 tgcaaggtga aaagttgttt ctcctctata tacttctgaa tattccaatg aaacatggca
     2341 caaagataag agttctgcaa gacaaaaaca aagtgcccgt tctttattta aaaacaatct
     2401 aaataatttg catacttcta agtaataact tatctttgca aaaaatttaa aacaaaatgc
     2461 gtttatccga attaagaaca ggagaaaaag gcgtaatagt caaggtttta ggccacggtg
     2521 gtttccgcaa gcgaatcgtt gaaatgggtt ttattaaagg aaaaaccgta gaggtaatct
     2581 tgaacgcccc tttgaaagac cctataaaat acagactact aggttacgag atctccctcc
     2641 gaagacaaga ggcagatatg attgaggtgg taagcgagca ggaagcacgc acgatgcaaa
     2701 acccttacca tggttccata acagaagatg tacccgtgcc cgaatcagaa ctggtggcac
     2761 tggcaaaagg caaacgccgt acaatcaatg tagccttagt aggtaatccc aattgtggaa
     2821 agacttcgct attcaatatt gcatctggcg cccacgaaca tgtaggaaac tacagtggtg
     2881 tgacagtaga tgccaaggaa ggttttttcg acttccaagg ttatcatttc cgtattgtag
     2941 atttacccgg aacctattct ctttcagcct atactccgga agaactttat gtacgcaaac
     3001 atatcattga agaaactccg gatgtaatta tcaatgtggt agactcttct aacttggaac
     3061 gtaatttcta tcttaccacc caattgattg atatgaatgt gcgtatggtt atcgccttga
     3121 atatgtacga tgagctggaa gccagcggaa ataaattgga ttatacccaa ttaagccagc
     3181 tgatcggggt gcctatggta cctactgtct gccgacgggg agaaggtgta gacaaactgt
     3241 tccatgttat catcggtatt tacgaaggag gagatttcct gtcacaaaag ggcgaaatac
     3301 gttctgaaat tctggaagac ctgagagact ggcacaaaac ctacgtaccc gaccacgaat
     3361 tcggaagcca caaagaagag gaagatgccc gcccacgcgg atatatgcgt catattcata
     3421 ttaaccacgg tcctgaactg gagcgcagta tcgaagaagt caagaaagca atcagtcaaa
     3481 acgaagacat acgccataaa tattccaccc gcttcctatc catcaaatta ctggaaaacg
     3541 atagggaaat agaaaatttc atctctacac tgcctaatgg caaagaaatc atagcgatac
     3601 gcaacaagga aacattacgt atccgtaaag tgatgaacga agacagcgag caagctatta
     3661 cggatgctaa atatggtttt atcaccggag ctttgaaaga aacattcacc gacaatcatt
     3721 tggaaaaaga acaaacgacc cgcgtgatag acagtattgt gacacatcgc atttggggat
     3781 atcctatttt tttcctgttt ctttatatca tgtttgaggg aacctttgtt ttgggtgact
     3841 atcctatgca aggtattgaa tggctagtag accaattagg caacctgata cgaaacaata
     3901 tggctgaagg tcctttgaaa gacttactga tagatggtat tatcggtgga gtgggcggtg
     3961 ttatcgtttt cctgccgaat atcctcatat tatacttttt tatttctata ttggaagatt
     4021 cggggtatat ggcacgcgcc gcatttatca tggataaaat aatgcaccgg atgggactgc
     4081 atggcaagtc ctttatccca ctgattatgg gattcggttg taatgtacct gccataatgg
     4141 caacacgtac tatagaagat cgaaagtcca gactaatcac catgttggtg aatcctttaa
     4201 tgtcctgtag tgcgcgtctt cccatatatt tagttatgat aggtgctttt ttccctaact
     4261 gcgccagctt tatgttactt tgtatctata cagcaggtat tttattagca gtaataatgg
     4321 cccgtatttt cagtaaattt ctagtgaaag gagaagattc tccatttgtg atggaactcc
     4381 ccccctatcg tatgcctact tctaaaagta tcatgcgtca tacatgggaa aaaggagcac
     4441 aatatctgaa aaagatggga ggcattatca tgattgcctc aattattatt tggtttctag
     4501 ggtattatcc acggcatgat actcatgaaa gcgtagccga acaacaagaa aattcatata
     4561 tcggacaaat aggcaaagca atagagcctg ttatcaaacc gctaggattt gactggaagt
     4621 taggaatcgg acttatttca ggtgtaggcg ctaaagaatt ggtagtaagt acactaggag
     4681 tattatacac aaatgaagga gatgtggaaa atgtgaatct ttctgaccgt attcccatta
     4741 ctccactggt tgcattagct tacatgttgt ttgtattgat ctacttcccc tgtattgcca
     4801 ctttcgcagc aatcaagcaa gaatccggca gttggaaatg ggccatattc gcagcaggat
     4861 acaccactgg attggcttgg cttgttgcat ttaccgtatt ccaaatagga agtattatca
     4921 tttaataaac ctaaacctaa aattatttgt ttatcaagca tggaattaca acaaattata
     4981 gttattgcaa tcgtatgcct ctgtacaata tggataagta tacgtatctt tcagtatttc
     5041 aagcgcataa agaacaatag caatccgtgt gaatgctgta attctgattg cgccatgaag
     5101 tctatgcaca acaagccaaa gtgcggttgc gaaaaaaatg cagaaaagtg agaaaaaaat
     5161 agcaaaatat ttgcagatta aaaaaaatgt cgtacctttg caaccgcaat cgagaaacaa
     5221 agattgataa caataaggtt ccttggatga gtggcttagt cagcggtctg caaaaccgtg
     5281 tacggcggtt cgaatccgcc aggaacctcc tcatcacttc aaaaataaat atgcaaaagg
     5341 gaataatcca tagattattc ccttttgcat ataatatata aaaagcaacg ccttcaatta
     5401 ctcaaaagta ttcctattta cacctacatt caaaaggttt ctcggctcag tttgaaaaag
     5461 aacctggaat tatttctcta ttccgaagat taaggagcga gtctttctat tttccaaaca
     5521 ccatcagatt gaagcatata gagaaaacga tcatgcaaac gatttaccct accctgccag
     5581 aattcaacac gaacaggcat aacagcaaag cctccccagt attcagggcg atctatctct
     5641 ttccctatcc agcgcgtggt ttctttcaca aaatcacgaa taagttgtat cctgctttct
     5701 atcggttcgc tttgaggaga aatacgggcg ccaatacgac tcttgtaagg cctttttcta
     5761 aaatattcat ctgattcctg tggagatact ttagccgcaa taccttctat atgaatttgc
     5821 ctttccagtt catgccatac aaacgatata gagatagatg ggttatgagc cagatgttta
     5881 cccttgcgac ttccatagtt agtataaaaa ataaatttgc catcatgcaa atctttcaac
     5941 aacacagtcc gtattgccgg tttcccttcc ggagaaacag tacctaccaa catagccgta
     6001 ggctcattta cctccgcatc tatcgcttct tgcagccact ttgtaaaaag gacaagtgga
     6061 ttatcaggaa gatcactcct tttgagacca ccctttgtat attccctcct gattgtcgcc
     6121 aaatcagcct tcattatttt ttctttaact cttaacctat attctttcat taacacttaa
     6181 atattcttta ctcaataaat tccccaaaag accatatcaa aatggacacc atacctcaca
     6241 taagtatgaa aacaatcttc taaaagaaaa ggtttagcaa tttctcaccg ctatgcataa
     6301 ttgaagaagg acttattttc atttttttga aatacaaaat ctttttgcaa accatacatt
     6361 ttcaatcatt ccactacaca catttttctg taatacaaga agatatattt ttgatagatt
     6421 taattttcat agacaatact agctacaaca gaagacaaat tatccttttt tattgcaaaa
     6481 tcaccctaca ataagaacta aagcctacac ttgtttgtta aatagaaaaa taagaatagc
     6541 aaaacgactt gctaccaatg cacaaactat ttaattaaat aatgattgac tgtttatgaa
     6601 aatcttatta ataggagagt atagcaatat acattggact ttagcaaaag ccttaagaaa
     6661 tatgggacat agagtcgatg tattatccca cagcaattta tggctaaaca actctgacta
     6721 tctctatccc aaccggtcat caatccgttg gggagttctt aaaaacacgt tcaatttact
     6781 gaaaaccctt ccccaactca gaggatatga tgtggtacaa cttgtcaacc cttacttttt
     6841 agaattaaaa cccgaactgc ttcagtacgt attccaatat cttaaaaaga acaacaagaa
     6901 gatattttta ggagggtttg aatatgattt ttactggatt tacatgtgct taaataaaaa
     6961 cgctctccga tataatgatt tttatgccaa tggcactttt cgtgacacca ttgacaacaa
     7021 aatggcaatt ataaattgga tgcatggatt cagaggaaaa ttaaaccgta tcatcgcgaa
     7081 caattgtaat ggaatcatca ccagtcttta cgaatcctat ttagcctacc aaccctattt
     7141 ctctggaaaa accaaataca ttcctttccc gatagaatca ttgcctcacc cacaaatccc
     7201 ttttaaaaaa atagaaaaag taaaattcta tatcagtcta aaacatcatc gtgaagaatg
     7261 gaagggaaaa gacgaacttt atagcgccct ctataaatta tattacagac atccatctgc
     7321 atgcgaaatc aaacaaaccg ttttcactcc gtatgatgaa tgtgaacatt ttatggacgg
     7381 gtgcgatgta atgttagatc agctttattc ttattctccg ggattaaatg cattatacgc
     7441 catgagcaaa ggaattgtag tggtgggagg tgcagaagag gaacattaca acttattagg
     7501 cgaagacaga cttcgcccta tcatcaacgt acgccccgaa ggaaatgaca tttataacaa
     7561 actagagagt ttattagcca atacaaataa aatttctcaa ttatccgccg acagcattga
     7621 atatattaaa aaacaccatt gtccaataaa ggtggctaaa gaatgtttgg atttttggga
     7681 gaaaaattaa ttccacctat taacacttca ctatcagcac cttattattt ccatcaaaaa
     7741 atatatctaa aaaaaagagc aaaaggtttg catatttcaa tttatcccct tatctttgta
     7801 ctgcgtttga gagataacgc ttctgataag aaggaagttt gggtgagtgg ctgaaaccac
     7861 cagtttgcta aactgacgta cgggtaaccg taccgggggt tcgaatcccc cagcttccgc
     7921 gaataagtcg taaattaatt ttacgactta ttttttatat tcatttttca acagtttgct
     7981 gtcaaggctt tcgggaggaa gagtaaaggt gctttttaga ctttcaattt tactacataa
     8041 aacatatgat acttcttcat agaaattaaa ttccgattta taatagtaat agcataaaaa
     8101 aaatcatttt ttattttgca gattaaaaac aaacttctaa ctttgcaccg tcttagaaaa
     8161 agaattaaga ctaactgatg gcggtatcgt ctagtggcct aggacgcagc cctctcacgg
     8221 ctgaaactcg ggttcgattc ccggttccgc tacttttaga agctaattgg tttattgcca
     8281 ccaattagct ttatttttta tggaattgtt ataaagagtc cttattgttt tttcatttat
     8341 tgaccacttt atacttaaaa atgcacaagt attcgcatta tacctactaa tagtgatgca
     8401 tagctcacaa aaaaggagta cctttgcagc cctaaatctc ttaataatgg aataacagta
     8461 tggaaatgaa caaagttttt aaggatggat tgtggagtaa ggaaattaat gtttcagact
     8521 tcgtacatac caacattacc ccttatgagg gcgatgcctc atttctggca ggccccacag
     8581 agcgaactaa aaaagtgtgg aacgaatgcc tcaaggcact agaagaagaa cgtgccaata
     8641 acggagttcg ttcccttgat aatgtaacag tatctaccat cacctcacat aaagcaggat
     8701 acattgaccg tgaaaacgaa ctgattgtag gtcttcaaac ggatgaactt ctgcgccgtg
     8761 ccatcaaacc ttatggtggt atcaaagtcg tagaaaaagc ctgccatgaa aacggtgtgg
     8821 aagtagatga aaaagtaaag gatatcttta ctcattatcg caaaacccat aatgatggcg
     8881 tatttgatgc ttacaccgaa gaaatccgct ctttccgttc actcggtttc ctgaccggtc
     8941 tgcccgataa ttatgcacgc gggcgtatca tcggtgacta ccgccgtttg gcactgtatg
     9001 gtatcgaccg actgattgaa gcaaaacaag aagatttgca caatatcacc agtccgatga
     9061 ccgatgcccg tatccgcctg cgcgaagaag tagccgaaca aatcaaagca ctgaaagaaa
     9121 taaagatatt gggtgaatat tacggactcg acttgggtcg tcccgctact aatgcacaag
     9181 aagctgttca gtgggtttat atggcatatc ttgctgccgt gaaagaacaa gatggagcag
     9241 ctatgtcatt gggcaacgtt tcttcattcc tggatatcta tattcaatat gatttggatc
     9301 atggtaaaat tgacgagtca tttgcgcagg aactggtaga ccagttcatt atcaagttgc
     9361 gtatggtccg tcatctgcgt atgcaatcat acaacgatat ctttgcaggt gatcccacct
     9421 gggtaaccga gtctatcggc ggacgcttca acgacggacg taccaaggtt acaaaaactt
     9481 ccttccgttt cttgcagaca ctatacaatc tgggtccgtc acccgaacct aatatgactg
     9541 tactgtggag tccggaattg ccggaaggtt tcaaagaatt ctgtgcacaa gtttctatcg
     9601 acacttcttc tatacaatac gaaaacgaca cgctgatgcg cgaagtgcgt aactgtgatg
     9661 attatggtat cgcctgctgc gtttcttatc aggctatcgg caaacaaatc cagttcttcg
     9721 gagcacgttg caatctggct aaagccctat tgctggctat caatggcgga cgttgtgaga
     9781 atacaggaac tgtaatggtg aaagatattc ctgtattgac aggggacttg ctgaactttg
     9841 aagaagtatg gtctaattat aagaaagtat taatgcaaat tgcacgtgtg tataatgatg
     9901 cgatgaatat cattcactat atgcacgata aatattatta tgaaaaggct caaatggcat
     9961 tcattgatac cgatccacgt atcaatctgg catatggcgt agccggtctg tccattgcca
    10021 ttgactcatt gtctgccatc aaatacggca aagtacgtgc caaacgtaat gatataggtt
    10081 tgaccgaagg ctttgatatt gaaaatgcat atccttgctt cggtaatgat gatgaccgcg
    10141 tagaccactt aggggtagat ttggtttatt tcttcagtga agaattaaag aaacatccgg
    10201 tatacaaaaa tgcccgccct accctgtcac tgctgactat cacctccaat gtaatgtacg
    10261 gcaagaaaac aggtgccact cctgatggtc gtgccaaagg agtggctttc gctccgggtg
    10321 ccaacccgat gcacggacgt gacaagaacg gtgccatcgc ctcattgagt tctgtagcca
    10381 aactacgcta tcgtgatgcc caggacggca tcagtaacac gttctctatc gtaccaaaat
    10441 cactaggggt agaccaggaa acccgtatag agaacctggt aaccatgatg gacggttatt
    10501 tcaccaaagg agcacatcat ctgaatgtaa atgtgctgaa ccgtgaaatg ttggaagatg
    10561 caatggaaca tcctgaaaaa tacccgcaac taaccatccg cgtatcaggt tatgccgtaa
    10621 acttcatcaa attgagccgt gaacatcagc tggaagtaat cagccgttct ttccacgaaa
    10681 gaatgtaaca tcacatatac attcatcgta ggggcgggtt ttaaacctgc ccttaccagt
    10741 ttaaagacaa accattatga tcagagtcca ttcttacgag tcaatgggga cgtttgacgg
    10801 tcccggttta cgcttagtcg tatttttaca aggatgcaat ttccgatgcc tctattgtgc
    10861 caaccccgac acaattgaca ccaaaggtga aagtacggaa acaacaatag acgaaattgt
    10921 gcgtatggcc gtcagccaaa aagctttttt cggtaaaaaa ggaggtgtga ctttcagcgg
    10981 cggcgagcct acattgcaag caaaagcact gattccgtta ttccagcgat taaaagaaca
    11041 aagcatccac atctgtatag ataccaacgg cagtatatgg aatgaagaag taaaggaact
    11101 gctacaatgg acagacctcg tattattaga catcaaggaa tttaataatg tgcgccatcg
    11161 gcaactgaca gaacgcagca acgaacaaac catacgtacc gccggatggc ttgaaaaaaa
    11221 cggaaagcct ttttggttgc gctatgtatt agttccaggc tatagttcct ttgaggaaga
    11281 tatacgggca ttaggagagc acttcaagaa ttatcaaatg attcaaagag tagaaatact
    11341 accttatcat acattaggcg tacacaaata tgaagccatg ggaaaagaat acaaactaaa
    11401 cggaataaaa gaaaatactc taaaacaatt ggaaacagcc aaaacgttat ttggtgaata
    11461 tttcaatacc gtatatttaa attagaaata tactgaagac aagatgttgc tataaatcaa
    11521 tggaaatatt tcatcatttc aataaaatta tctaatttcg catctaaaac ataaattatt
    11581 ataaatatga aaagactact attactctgc ctaacttaca ttatgtgtgt aggcaaccat
    11641 cagatggctg ctcaagactc ttctgaaagt cctggtattt ttaattcatt agctgtaggc
    11701 gtcagtgcaa gtaccacagg tataggtatt gatgtagcca gtcctatagg aagttacttg
    11761 gctgtacgtg caggagtttc ttttatgccg aactttactt attctacaga tgtggatgta
    11821 gatattgaag gttcttatga aggaaatata cctaccagca tagatgtaga aggaggaatg
    11881 ggacgtactg ccggtgaaat attgctgaat gtatatcctt tcaaatcatc tagttttttt
    11941 gtatgcggtg gtgcttattt cggaggagga aaactcatca agattaaagg gcacagcgat
    12001 gagttggcag aactgattaa agaaggacaa gaagtaggta ttgaaatcgg aaactatcgt
    12061 atacctgtag atcagaacgg aaatatatct ggtggtttga aggtttcttc attccgtcct
    12121 tatcttggac taggtttcgg aagagcgatt cctaagaaac gaattggctt catgttcgaa
    12181 atgggtgtgc aattccataa cactcccaaa gtatatacca ataacggaga tttgtctgat
    12241 ttaacagcag aagctgataa tgatttcact gatatcatag acaaacttac tgtctatccg
    12301 gtacttaagt tccgtttgtg tggcaaaata ttctaataat attctataaa ataaaaggag
    12361 atgagcccta taattttcgc ctcatctcct ttttatatat aagaaacaat acacttatat
    12421 cagcaccacc atcacatcac gtgccccatg agcacccatt accaaagcct gctcaatatc
    12481 agccgtcttt gacggaccgg aaataaaggt tccgaagcca tattcgcctg tatcaatcag
    12541 tttatatgct tcatgcatat tgttcacaat cttattcttg tttagaagaa taaccaattt
    12601 ttcggcaata aaataaatgg cacgctgctt tacatcctgt tctatccata ccgcaccatt
    12661 ctccgcaacc ccaatctttc catctataac ggccaaatcc gtcccattca gttctgcagg
    12721 gtcttccaca tcatcgggat taaatgtcgc acatgtaata gtcttcagat tagaagcgat
    12781 gcgtttggct ccaggataag cctttttaat gaaatcattc acgtcctcct ctttctccaa
    12841 aagaatggct tcccctccta cctgcttcat gatgagataa aactgttcca ccttactggg
    12901 ataagttaat gccatatctt ccaatggctt taaatccggt ttctcatatt ttacatgtgt
    12961 agcacgccgg atgctctgca atatatcttc tctgctgctc ataattactt cactttacct
    13021 ttcttccaca tttcattgaa actctcctta gcaaatttcg gcatctcacg cccttttccc
    13081 cagtcattca atccgttata gataagaaaa cgtggcattc cgtttaccaa tggcgcccat
    13141 tttaatgcca tattgaatat caaagggcga ttcatcatga attccatgcc accggacatt
    13201 acccttttca tccggtctgc cttacccaat ttatccaaat cctgacgcca cagatagatc
    13261 tgctccgcca aatccacctt agccggacac acaaacgaac aggaataaca caaagaacaa
    13321 gccgacacat tgtcataata atgcaacggc gccttcaaca ttcccaggtt aatcccgata
    13381 gggccgggaa taaaataagt ataagagtac cccccactac gtctatatac aggacatgta
    13441 ttcatacagg ctccacaacg gatacaattc aaagttttga tatgcttttg gtcggccaat
    13501 atcttactac gtccgttatc tacaataata atgtgaagct ccccaccctc tctaggcttt
    13561 cggtaatgag aagtatatgt agtaatgggt tgtcctgtag ccgaacgggc caacaagcgg
    13621 gtgaacactc ctaaagattc acggtccggc acaatttttt ccataccaaa agctgcaatc
    13681 tgtaatttag gctgggaagt acccatatcc gcatttcctt cattggtaca taccacaatc
    13741 tcaccagtag aagctacagc aaagttagca cctgtcatag ccgcctcagc atgaataaat
    13801 ttctgacgga gattcttccg ggctgcatgt gtaaggtaag tagggtcaaa atttcctttc
    13861 tccgtaccca tctctcgctc gaaaagctca cctacctgtt cacgtttgat atgaatagcg
    13921 ggtaatacaa tatggcttgg cttcagatgc atcaattgca agatacgctc tcccaagtca
    13981 ctttctacca cttcaattcc tttgttttcc aaaaaagggt tgagttcgca ttcctcggcc
    14041 aacatggatt tgctttttat aaaatgcttc actccgtgct ggttcagaat attgtagaca
    14101 atattacaat actcatccgc atcctttgcc caatagacat gggctccatt agcacgcgca
    14161 ttgttttcaa actccaccaa taattcatcc aaatggctgt tactatatag tttagtagca
    14221 catgccatat tacgcaattc ctcccattcg ggaacttctt tactcagtct gtcacgcttt
    14281 gccctaacca gccaaagtgt ttcgtcatgc catgcggcct gtttcttgtt tttcagaaac
    14341 tccgcagccg cttttgaatg tttcgtactc ataatcctgc cgctaagatt tcaacaatgt
    14401 gcaatgtctt gataggaagt ttgtcacggg caatgatgcc attctgatgc atcaggcacg
    14461 aactgtcggc ccccacaatg tattcagcac cggtagcgat atgacgcatc accttgtcat
    14521 gccccatctg cacggaaacc gcatcttcct ctacggcaaa cataccgccg aaaccgcaac
    14581 attcgtcttt acgttccggt tccacaactt ccactccttc taccaaagag agcaaatcac
    14641 gcagtttgct gaaataagga atattaagtt cgctggcaga agaaagtttc atcaatctca
    14701 ctccatgaca actgttttgc agactcactt tatgtggaaa cttggctttc aacgaagaag
    14761 gtctgacgat atcatgaata aactcacaga tatcatatat cttacctccg ctggcgcacc
    14821 gatgtttgtc ttctttcaac aaacgactgt agttatcacg cacaaaaacg acgcaactgg
    14881 ccgaaggacc tactatataa tcgtaattct taaactgttc gtcaaaatgg cgggctaaat
    14941 ctaccgcttt attctcgaaa cctgcattcg ccatcggttg accgcaacaa gtctggttga
    15001 gaggataatc cacgtccact cccagacttt tcagcagctt gtacgaggct atccccacct
    15061 gcg
//
