LOCUS       c00046_gnlPro..        24639 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JGDDBKFI_46.
ACCESSION   c00046_gnlPro..
VERSION     c00046_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:20:49
            Original ID  :: gnl|Prokka|JGDDBKFI_46
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 92910
            Orig. end    :: 117549
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24639
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[102910:107549]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14639
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..24639
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24639
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             241..1755
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 267.2; E-value:
                     6.8e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_69"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-81, bitscore:
                     267.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSSQKDIINDILSAMQCYPENEAFIIDDKHYTYAQLGEIIASI
                     THSLSEIKDEKIGIVAENRIETYAAILAVLAGGKTYVILHPAYPKERNLKIAALAGLRT
                     LLCTSDTDRSAFGTGHFRIIDTDRLPGKALSEQQSHSSDEERNAYIIFTSGSTGEPKGV
                     PITRANLNAFYRAYSSLDWNLDEHDRMLQMFELTFDVSVVSLLYPLTLGAAVYTVGHQD
                     VKHFKVFELLEKYQLTFATVTPSLLQLLSPYFDEINLPSLKYLGVSAEASQTELLERFR
                     KSAPNATFINLYGPTEATIYCTCYRIPASDKCKHYNGMVAIGKPFPGIRAIIADEEGNE
                     LPQGETGELWVSGRQVMKGYLDDPEKSTLVLIHRPDGQIYYRTGDLCILDSDGDIIYCG
                     RKDYQVKIQGFRIELSEIEYTAQSFFKTPCSVAAVPLLCDGICNELHLAVETTECTQSA
                     LIEYLKEKLPKYMLPKQIHCISQFPVTNSNKTDRKKIAELIKEKKL"
     CDS             1770..2012
                     /locus_tag="ctg46_70"
                     /transl_table=11
                     /translation="MNREEVLKQLQSIFRDILKKDNVCIDESSTSKDVDGWDSLTHMQI
                     IAQIEKHFGVRFNFREVIKFKNVGDLCSALLTKME"
     CDS             2016..3398
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MBOAT"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_71"
                     /sec_met_domain="MBOAT (E-value: 5.2e-21, bitscore: 68.6,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFLSFSFLALFTLCFFLYYAVKGRARNLIQLVTSCIFIGWYYLP
                     FLLTAVVVALFTFFWAQWMESRAKAGKKTKPVYIAGIIALIGGWLLLHGTVIDDIIFPL
                     GMSFYTFQAISYLTDVYWQEQRSERNWVDFLIYMLFFMKFLSGPIERGGDLLPQLKDPR
                     PFIYSNAVTGLKYILLGLIKKLLIANQISPQTDVMFHSIHDLSGVQLLMTCLLYPIELY
                     ADFSGYTDIAIGGAYMFGIKLSPNFNRPFAARSTADFWRRWHMSLSFWVRDYLYVPLTA
                     GTRNWGQWGIYFSLLITFLALGLWHGAGLTFAIYGLIQGVLICWEMKTAAFRNNLPQYI
                     GKYAADSLLIVRTYLLFALSLIFFRVQSLSDAWYFLRNISFEVHSSWKEMNIGIRDHNC
                     IVAGSALLLVLIYEYYASKYNLMETLERQPAWLRWSVYYLLVFALLMLGKFDTETFIYL
                     QF"
     CDS             3417..4457
                     /locus_tag="ctg46_72"
                     /transl_table=11
                     /translation="MLHHSSRISPKTRFCLKLLLLILPLIPIVVVYFMFDPYRVLHPYK
                     RFNDSPMLLNEAHVGWQNYLQNRDSIAYNSFILGNSCTMAFLTGEWEKYLDKNDHAVRF
                     YDNGESLGGVRQKLQLLDSVGAPLKNVLIVLDKKSLDKNAPLSGNNHLFSAEAAGISQL
                     GFQLRFLQEFLYPDRMIPYIDYLIRHKYAPYMKGVINPGDPVREPYTNNFINPREKEIA
                     QDGEIYWSRHEKEFKKRTNAGMEELPVIFASQIQVLRSIKKICDKHHTNLKFVIGPDYY
                     QKKASREDIKILKAILGDSAVWDFTGINEYTADIHHYYEPGHYRPLLGARLLKAIYQDQ
                     DTCHRQ"
     CDS             4562..4954
                     /locus_tag="ctg46_73"
                     /transl_table=11
                     /translation="MKKILLLLSVCISFSSCCTLFSSSKQDITFTGMNGTKIYEASTKQ
                     KIAEIKEDNSVTVQIKKKREDKQLVAKKEGYQTTPFVLESTFNNACLWNILFWPGFLVD
                     LGTQKMNKWDNTIINIEMEKENTENK"
     CDS             complement(5144..5773)
                     /locus_tag="ctg46_74"
                     /transl_table=11
                     /translation="MLSDGDFQYIPYLFISMLANLDRYKIVLASNSPRRKELMTGLGVD
                     YVVKTLPDVDESYPDTLQGEEIPLFIAREKAAAYQSMIGPEELLITADTIVWHEGKALG
                     KPVGRQDAIEMLRSLSGKSHQVITGVCLTTREWQKCFAAVTDVRFAILDEDEIAYYVDH
                     YQPMDKAGSYGVQEWIGFVGVESISGSYFNVMGLPIQKLYRELKQL"
     CDS             complement(5757..6278)
                     /locus_tag="ctg46_75"
                     /transl_table=11
                     /translation="MSTINYDLTRIKALAFDVDGVLSANVIPLHPSGEPMRTVNVKDGY
                     AIQLAVKKGLRIAIITGGRSDVVRKRFIGLGVSDLYFGSAVKIHDYRGFRDKHGLTDEE
                     ILYMGDDVPDMEVMRECGLPCCPKDAVPEVKAIARYISYADGGYGCGRDVVEQVLKAQG
                     QWLSDDAFGW"
     CDS             complement(6299..7090)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_76"
                     /sec_met_domain="F420_oxidored (E-value: 2.5e-13, bitscore:
                     43.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTEESAR
                     ELAQKVEAEYTTDLAEVNPYAKLYIVSLKDSAFAELLQGIVEGKREEALMVHTAGSIPM
                     NVWEGHVSHYGVFYPMQTFSKQREVDFKEIPFFIEASSAEDAAFLKAIASTLSNRVYDA
                     DSEQRKSLHLAAVFTCNFTNHMYALAAELLKKYNLPFDVMLPLIDETARKVHELEPKTA
                     QTGPAIRYDENVIGNHLRMLADDPAMQRLYELLSRSIHERQ"
     CDS             complement(7087..7356)
                     /locus_tag="ctg46_77"
                     /transl_table=11
                     /translation="MGVLYLIDKLIHFSTLGIPWVMNKDNLLLYTAVIFLFIKRDKSVG
                     LVLLGLWLVLNIGLIVSLLGSMSGYLLPLALLIIGGILYLISTR"
     CDS             complement(7422..7919)
                     /locus_tag="ctg46_78"
                     /transl_table=11
                     /translation="MRKFTGEELSQEDVVALLKAALMAPTSKRSNSWQFIAVDDKKLLS
                     ELSHCKEQASAFIADAALAIVVTADPLASDVWIEDASIASIMIQLQAEDLGLGSCWVQV
                     RERYTATGIPSDEFVRGVLDIPLQLQVLSVIAIGHKGMERKPFNEDHLQWEKIHINKFG
                     GK"
     CDS             complement(8125..8667)
                     /locus_tag="ctg46_79"
                     /transl_table=11
                     /translation="MLEEILEFNKKFVENRGYEKYITNKYPDKKIAILSCMDTRLTELL
                     PAALGIHNGDVKIIKNAGAVISHPFGSVIRSLLVAIIELGVEEVMVIAHSDCGACHMNS
                     DEMIAHMKKRGIKSETIDMIRYCGVDFNSWLGGFDDPVKSVRGTVRSIENHPLIPKDVR
                     VHGFIIDSLTGELTRVE"
     CDS             8785..9768
                     /locus_tag="ctg46_80"
                     /transl_table=11
                     /translation="MPLKLTTYYQGSEIPDFPGTNTFHSKELFQIYEETPGYTPLLIMA
                     SEDGKPVARLLAAIRKSIRIFPPAFIKRCEIYGTGEYLIAEADKERIFGEMLEHLTTEA
                     LRNSFLIEFRNLENAMFGYKYFRSNRYFPVNWLRVRNSLHGIENAEQRFSPSRIRQIKK
                     GLKNGAKVDEARTVEEIREFSNMLRHLYSSRIRKHFPNIIFFQHMDTRLIHSRQAKIFI
                     VRYKDKIIGGSACIYSGNDAYLWFSGGMRKTYALQYPGILAVWKALQDAHQNGFRHMEF
                     MDAGLPFKKHGYRDFVLRFGGKQSSTRRWFRFRWQWLNDLLIKIYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_81"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.3e-23, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10531..12084
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_82"
                     /sec_met_domain="CT_Btheta (E-value: 3.1e-290, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             12105..13019
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_83"
                     /sec_met_domain="OAD_gamma (E-value: 1.9e-15, bitscore:
                     50.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     VAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             13045..13476
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 69.7; E-value:
                     4.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_84"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.2e-21, bitscore:
                     69.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKRGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             13479..14639
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_85"
                     /sec_met_domain="OAD_beta (E-value: 6.1e-153, bitscore:
                     502.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALLIGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRALTTKHERLIRMKPPRIVSHTEKVIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASQFLTWDSILIFILGAFSFIIATASGVMFVKFFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             14788..16119
                     /locus_tag="ctg46_86"
                     /transl_table=11
                     /translation="MRTRTMKPLFLIFCLCLSPLLMGQNQNKIQEAMANYDYETAVELI
                     NKEPPTIPLLMQKAKALKGIGSNAEALRSIRQVIAEDSTNQQAHIEAAECCKAMAKYND
                     ALDYYRKAISLNPKNKYARLQFINLLCNTKNYAEAFGESSMMSETDSSAVVLHLQAQSL
                     EGMQQILPAIGCYEVIQDKYPDDYLAAAKLGNLNIVAGYPEYAIQATERYRERDSTNLI
                     VNQQNALAYCHAEQYPTAIKRYEKLCQQGDSSTQTLYYLGVSYYADEYYYEAHACFSKL
                     QKEMEENPNLLYYLGRCCAKTSWKKEGIEHLEKAIELTIPKDSTMIRLYKGLVDCCKLA
                     QDTPKQIQALRELYKYDKTNHKLLYDIAWNYSYQLKDNKSAERYLQAFLKTRKANARKE
                     EPVSEKGELVLGLENYYNAAENWLKDLQKEKFFKEGIPLESQKQ"
     CDS             16133..17425
                     /locus_tag="ctg46_87"
                     /transl_table=11
                     /translation="MKHWILLLYLGFSVMLRAQNTASVQEAMANYDYKTVIRLIDEESA
                     SPQLLIQKAKALKGLGRTAEALSTLQHIIIELPENQQALVEAAECCRQLSKFNEALGYY
                     RKVMELNPEHIYAHLQYTRLLYNYQRYGDALRESIALARKDSSATVLRLMAESMEGAGM
                     PVESMFCYLSIIRKYPSDYLSVAKLGSIFNTMKDYEGAIALTEAYRRTDSTNVEVNRQN
                     ALAYCLRKEYPTAIKRYQDLTARGDSTLLTCYYLGVSYYATKEYYKARDWLLKAKSCQS
                     PGANLLYYLGRSCSKTLWKQEGIGYLNQAIALTIPADSIMERLYSGLADCYRQTKQIRD
                     QIKATKEQYKYAPDKHILLYNLAFLSDKIEDTKATEHYLQAFLRTKSKQNAVLQQPDDD
                     EEEPTPYIDYYKSATNKLESIRKEKFLKGEK"
     CDS             18099..19949
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_88"
                     /sec_met_domain="Alpha-amylase (E-value: 8.4e-63, bitscore:
                     206.2, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLLLLGSFLLSLTTYAAMNISKIDPPFWFTGMNNPELQLMVY
                     GEGIGQASVSVNYPGVSLSSVVKLESNNYLLVYLHLDKEVKPGKMPITFTVGKKKLVKE
                     YELKARSKAGVDHKGFDVSDALYLLMPDRFANGNPDNDRIEGMAEYKVDRNDPNARHGG
                     DLAGIEQNLDYFTDLGVTALWFTPVLENNMKGGSYHGYATTDYYKVDPRFGTNEEYRSL
                     IAKAHNRGIKVVMDMIFNHCGVEHPWIKDMPSKDWFNHADFKNNFVQTSYKLTPHVDPY
                     ASEYDFDQMNNGWFVEAMPDLNQKNPHVYKYLLQNSLWWIEYADIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPRNSHLKTVMDFSFFDKV
                     NTAKNEQTDTWFKGLDRVYNNFVYDYLYPNPASVLAFIENHDTDRFLGEGENLDMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWADDKENALTPEGRTRLQNE
                     SYNFYRNLLNWRKGNDVIAKGSMKQFMVQHGVYAYARQYKGKTVFVLLNGTDKEVKLPL
                     KYYAEVLKDKTQGKDVISGKVTALNEELTMAPRQSMVIEL"
     CDS             20107..20547
                     /locus_tag="ctg46_89"
                     /transl_table=11
                     /translation="MTNNESERELVLQTLRTWMAFRQAVQRVLKRHNVDMTFEMLQVMN
                     CLWNKQGISQQSLAEKTAKDKACLTNLINNLEKKNWVIRKEGPSDRRNRLIFLTPQGEE
                     LALTVKPLINDIYAQTGAEMEASRITECIEDLKRLHEVLNEI"
     CDS             20560..21627
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_90"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 3.4e-11,
                     bitscore: 36.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTHQIKLKQLRRLKFRNIFLNTVCILLALAGISWTVNYFWKYAR
                     YEITNDAVVDQYIAPLNIRIPGYIKEVRFTEHQYVHAGDTLLILDDREYRIRLKDAEAA
                     LMDALGSKEVLNSGIRTSGVNVAVQEANIAETLARLSQQEAELNRYTRLLKKQAVSQQD
                     YELAKANFEATQARYNALLRQKEAAQSQYSETSKRSTGAEANILRKEADLEMAKLNLSY
                     TVVTAPYDGYTGRRTLEPGQFVQGGQTLSYLVRGNDKWVTANYKETQIAHIYIGQKVRI
                     KVDAFSGRTFHGTVTAISEATGSKYSLVPTDNSAGNFVKVQQRIPVRIDLNDASPEEME
                     CLRAGMMVETEAVRP"
     CDS             21632..23227
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_91"
                     /sec_met_domain="MFS_1 (E-value: 5.8e-13, bitscore: 41.7,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNLPTRPWVPQWLGIVTMFIVIFPITLLNGAYTGSMVEVSNT
                     LGVLSEDITMAYYSASVGMAVAYPIVPKIRTIATPKTLLLTDLLLQIFFSLVCAKTGSM
                     DVIMVCSFYMGFLKAFVMLEFIILIRPLFSPKNVRSEFYAYFYPIVFSGGQLSMAITAQ
                     LAYHYQWQHMYYFVTILLLIALLFVICFFRYARRPMHIPFKEMDGRSMFIIATAFLLTL
                     YTFTYGKTLDWFASPKIRVYVFVIPLLIVLFIHRQRTQGKPFVSLKPLFLHKSIIGYGF
                     MVLAMFLTATSSLVTNYMNSIIRVDSIHANSLSLWLLPGYVVGAVICFWWFRWQRWRFR
                     FLISGGMFCYVIYLAILYFGITPYGTYEMLYLPILFRGVGMMVIFIAFGVFVVEDLDPR
                     LTLSNAFFLISFRSVLAPVLSASFFNNMLYYLQAKGMNILSENMTLTNPLAEQKYNQAL
                     SNALAQGHEFSEAGQLAANSLYSTLQQQSLLLALKTLIGYVLILALVIAVIAAFIPFHK
                     TLKVAVVKTGDDMV"
     CDS             complement(23322..24326)
                     /locus_tag="ctg46_92"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKNPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYDENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTEPDEVVDFVTKTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFDVLDGV
                     MKELPGFPIVLHGSSSVPEEEVATINQFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAE"
ORIGIN
        1 taagtatcaa taaagtatcg tgttgtctat cccattcaaa gtcgtcggct atgaagccaa
       61 cgctatttcc ccttccgaaa gagggaaagc gagaccgggc acgtgcgtac cacacaatta
      121 acattcttta atcgattgtg cgtagggaga tcagaccatt tcactgtcat cttaataaac
      181 gatctcaaga agatatataa agaaccccta aacccaaaac atgaataaaa actaatggat
      241 atgacaacat cttcccagaa ggatattatc aatgatattc tttccgccat gcaatgttat
      301 cccgaaaacg aagcattcat tattgacgat aaacattata cttatgccca actcggtgaa
      361 ataatagctt ctatcaccca ttcgctatca gaaataaaag atgaaaaaat cggaatcgta
      421 gcggaaaacc ggattgaaac ctatgcggct attctggcag tactggccgg tggaaagacc
      481 tatgttatcc tgcatcctgc ctacccgaaa gagcgtaatc tcaaaatagc cgctctggcc
      541 ggactgcgta ctttgctctg tacaagtgac actgaccggt cagcattcgg caccggacac
      601 ttcagaatca tcgatacgga ccggctaccg ggaaaagcac tgtcagaaca gcagtcccat
      661 tcatcggacg aagaaaggaa cgcttatatc atttttacat cgggaagcac aggcgagccc
      721 aaaggagtgc ccatcacacg ggctaacttg aacgcctttt accgggcata cagttcgctc
      781 gactggaatc tggatgaaca tgatcgcatg ttgcaaatgt tcgaacttac attcgatgta
      841 tccgttgtat ccttactgta tcctcttact ttaggtgctg ccgtttatac ggtaggccat
      901 caggatgtaa agcacttcaa ggtgtttgaa cttctggaga agtatcaact gacctttgcc
      961 actgtcactc cctcactgct acaactcctt tcaccctact tcgatgaaat caatctgccc
     1021 tctctgaaat atctgggagt atcggcagaa gcatcgcaaa ccgagctgtt ggagcgattc
     1081 agaaaatcgg cacccaacgc aacgttcatc aacctatacg gaccgaccga ggctacgatt
     1141 tactgcacct gttaccgtat tccggcttcg gacaaatgca agcattacaa cggaatggtg
     1201 gctatcggaa aaccatttcc cggcatccgc gccatcattg ccgacgaaga aggaaacgag
     1261 ctacctcaag gagagacggg agaactttgg gtatccggcc ggcaggtaat gaaaggttat
     1321 ctggacgacc cggaaaaatc gacattggtt ctgatacacc gtcccgacgg acaaatctat
     1381 taccggaccg gagacttgtg tattctggat agcgacgggg atattattta ttgcggacgt
     1441 aaagactatc aggtgaaaat acagggtttc aggatagaac tgagtgaaat agaatatact
     1501 gcgcagtcgt ttttcaagac tccctgcagc gtggctgccg ttccgttgct ctgcgacgga
     1561 atctgtaacg aattacatct ggccgtcgag acaactgaat gtacccaaag cgcattgata
     1621 gaatatctga aagaaaagct gcccaaatac atgctgccga agcagattca ttgtatttcc
     1681 caatttccgg tgaccaatag taataaaaca gaccgtaaaa agattgccga actgataaaa
     1741 gagaagaaac tctaaaaaca ataataaata tgaatcgaga agaagtatta aaacaactac
     1801 aaagcatttt ccgtgatatc ttaaaaaagg acaacgtatg tatcgacgaa tcatctacct
     1861 caaaagatgt agatggctgg gactcgctga cccacatgca aattatagct caaatcgaga
     1921 aacatttcgg agtacgtttc aatttcaggg aggtcattaa gttcaagaat gtcggcgatt
     1981 tgtgcagtgc cttattaacc aaaatggaat aaacgatgca gttcctctct tttagtttcc
     2041 tggccctgtt taccctctgt ttcttcctct actatgcagt caaaggccgt gcccgcaacc
     2101 ttatacaact ggtaaccagt tgtattttca tcggatggta ctatctgcct ttcctgttga
     2161 cggcagtagt ggtagcactg ttcaccttct tttgggcaca atggatggaa agcagggcaa
     2221 aagccggaaa aaagaccaaa cccgtctata tcgcaggaat catcgccctg atcggcggat
     2281 ggctccttct tcatggcacg gtcatagatg atatcatctt tccacttggg atgtcatttt
     2341 acacatttca agccatcagt tatctgacag acgtgtactg gcaagagcaa cgcagcgaaa
     2401 gaaactgggt ggatttcctg atctatatgc ttttcttcat gaagtttctc tccggcccta
     2461 tcgaacgggg tggagacctg ttgccacaat tgaaagatcc ccgtccgttc atctactcaa
     2521 acgcggtgac cggactgaaa tatattttac tcggactgat caagaaactg ctgatagcca
     2581 atcagatctc cccacaaaca gatgtcatgt ttcattcgat ccatgacctc tcgggtgtac
     2641 aactgctaat gacttgccta ctctacccta tcgaactgta tgccgatttt tcgggttata
     2701 cggatattgc tatcggaggg gcctatatgt tcggcatcaa gttgtcgccc aacttcaacc
     2761 gcccgtttgc agcacgctcg actgccgact tctggcgccg ttggcacatg tcactctcct
     2821 tctgggtacg cgattatctc tatgtaccgc taaccgccgg tacccgtaac tggggacagt
     2881 ggggaatcta cttcagcctc ctcatcacct ttctcgcatt gggtttgtgg catggggccg
     2941 gattgacttt cgccatatac ggcctgattc agggtgtcct tatctgctgg gaaatgaaaa
     3001 cagctgcttt ccgcaataat ctgccccaat atataggaaa atatgcggcc gacagcttgc
     3061 tgattgtccg gacttatcta ttgttcgcac tctcgcttat attctttcgt gtacaatcgc
     3121 tgagcgatgc ctggtatttc ttacggaaca tctcgttcga ggtacattct tcctggaaag
     3181 aaatgaacat cggcatacgc gatcataatt gcatcgtagc aggttcggcc ctattactgg
     3241 tattgatcta cgaatattat gcatctaagt acaacctgat ggaaacactt gaacgccaac
     3301 ccgcatggtt acggtggagt gtctactatc tgttggtatt cgctctgctg atgttaggca
     3361 aatttgacac ggaaactttc atctatttac aattttaacc gaaacccttt acgcgcatgc
     3421 tacatcattc atcgagaatc tcccccaaga cacgtttttg cctgaagttg cttttactga
     3481 tcctgccgct gatcccgata gtggttgtct attttatgtt tgatccttat agggtattac
     3541 acccctacaa acgattcaac gactctccca tgctactcaa cgaagcccat gtgggatggc
     3601 agaattatct gcagaatcgc gattcgatag cctataactc ctttatactc ggcaactcct
     3661 gtaccatggc attcctgaca ggagaatggg aaaagtacct ggataagaac gaccatgccg
     3721 tacgcttcta tgacaacgga gaaagcctgg gcggcgtccg tcaaaagctt cagctgctcg
     3781 actctgtagg tgcacccctg aaaaatgtac taatcgttct ggataaaaaa tcactggaca
     3841 aaaacgctcc tttatcgggc aacaatcatc tgttttcggc cgaagcagcc ggcatcagcc
     3901 aattgggatt ccagttgaga ttcctgcagg agttccttta tccggacaga atgattcctt
     3961 acatagatta tctgatccga cataagtatg ctccttatat gaaaggggtt ataaatccgg
     4021 gagatcccgt cagggagcct tacacgaaca attttatcaa tcccagagaa aaagagatcg
     4081 cgcaagatgg cgaaatatac tggagccgtc atgaaaaaga attcaagaag cgaacgaatg
     4141 cgggtatgga agaacttcct gttatatttg ccagccagat tcaggtactt cgctccatca
     4201 aaaaaatctg cgataagcac cacacgaacc tgaagttcgt catcggtccg gattactatc
     4261 agaaaaaagc cagccgggaa gacataaaaa tattgaaggc tatactaggt gattccgctg
     4321 tctgggattt cacgggaatc aacgaataca cagccgacat acatcattat tacgaacccg
     4381 gtcattatcg tccgctgctg ggagcacgct tactgaaagc catttatcag gatcaagaca
     4441 cctgccacag gcaataaaag ttcctcccat aacagtagca cacacagaag aagagcatcc
     4501 tcgatccgaa agaaataatt atatcaaaga aaacaattat atcacattaa aaacttagat
     4561 tatgaaaaag attttattat tgctatccgt ctgtatttca ttttcatcat gctgtacatt
     4621 attcagcagt tccaaacaag atatcacctt tacgggaatg aatggaacta aaatctacga
     4681 agcatcgacc aaacagaaaa tagcggaaat caaagaagac aatagtgtca ctgtacaaat
     4741 caaaaagaaa agggaagaca aacaactagt agccaaaaag gaagggtacc aaacgactcc
     4801 ctttgtcctg gaatctacat ttaacaatgc ctgcctgtgg aacattctat tttggccggg
     4861 ctttctggta gatttgggta cgcaaaagat gaacaaatgg gataacacaa ttatcaatat
     4921 cgaaatggag aaagaaaata cagaaaacaa atgatcaaac tacaatttcg catggcactc
     4981 ttctccttcc acggagggag tcgccatacg gaatcatgcg acctacaagg aaggcataat
     5041 tcaccacaag tcaacacaga gttttttata aaagttcttt agagaatact actctgtgag
     5101 actctgtgct actccgttgt atatacgagt ttcggcacac tctctatagt tgtttcaatt
     5161 ccctgtataa tttctgaatg ggaagtccca ttacattgaa gtagctgccg gatatggatt
     5221 ctactccgac aaaaccgatc cactcctgca caccatacga accggctttg tccatgggct
     5281 gatagtgatc gacataataa gcgatttcat cttcatcaag aatcgcaaaa cggacatccg
     5341 tcacggcagc aaaacatttt tgccattctc gggtagtgag acacacaccg gtaatcactt
     5401 ggtgcgattt accggagagg ctccgcaaca tctctatggc atcctgcctt ccgacaggtt
     5461 tgccgagcgc tttgccttca tgccagacaa tggtatcggc tgtgatcaaa agctcttccg
     5521 gtccgatcat cgactgatag gcggctgcct tctcacgggc tatgaaaaga ggaatctctt
     5581 caccttgcaa cgtatcggga taagattcgt ccacatccgg caaagttttt actacataat
     5641 cgacacccaa gcccgtcatc agttctttgc gacgcggaga attagaggcc aatacgattt
     5701 tataacgatc taagttagca agcatactga taaataaata aggtatatac tggaaatcac
     5761 catccgaaag catcatcgga caaccattgg ccttgtgctt taagcacctg ctccaccaca
     5821 tcgcgtccac agccgtatcc tccatcggca tacgaaatgt aacgggcaat cgctttcacc
     5881 tcgggaaccg catctttggg acagcagggc aatccgcact cacgcatcac ttccatatcg
     5941 ggaacgtcat cgcccatgta gagtatctcc tcgtccgtaa gtccgtgttt gtcacggaaa
     6001 ccacgataat cgtgtatctt caccgcagag ccgaagtaca gatcggatac ccccaaccct
     6061 ataaaacgtt tccgcacgac atcgctccgc ccacctgtaa taatagcgat acgaagccct
     6121 ttttttacgg ccaattggat ggcataaccg tcttttacat ttaccgtacg catcggttca
     6181 cccgacggat gcaaagggat gacattggcg ctcagcactc cgtctacatc gaaagcaagt
     6241 gcctttatcc gggtaaggtc gtaattgatt gtgctcattt ttatttaatg tttcgggatt
     6301 attgtctttc gtgaatgctt cggctaagca actcgtataa ccgctgcatg gcaggatcat
     6361 cggcaagcat ccgcaagtga ttgccgatca cattctcgtc ataacggatg gccggcccgg
     6421 tctgggccgt cttaggttcc agttcgtgca ccttacgggc ggtttcatca atcaacggca
     6481 acatcacgtc aaacggcaga ttgtatttct taagcaactc ggcagcaagg gcatacatgt
     6541 gattggtgaa gttacatgta aacacggcag ccagatggag acttttacgc tgctccgagt
     6601 cggcatcgta cacacggttg gacagtgtag aggcaatggc tttcagaaac gcggcatctt
     6661 ctgctgaaga agcctctatg aagaaaggaa tctccttaaa atctacctcc cgctgcttgc
     6721 tgaaagtctg catgggatag aacacaccgt aatgcgagac atgtccttcc cagacattca
     6781 tcgggatgct acctgccgta tgcaccatca atgcctcttc ccgcttacct tcgacaatgc
     6841 cctgaagaag ttcggcaaag gcggaatctt tcagtgaaac aatatacagc ttcgcatacg
     6901 ggttcacctc tgcgaggtct gtcgtatatt cggcttccac tttctgtgcc agctcgcggg
     6961 ccgactcttc cgtacggcta tacacctgta cgatacgaaa acctttccga tataaggctt
     7021 ttgccagatt agtggcaaga tttccggcac cgataaatac gatcggcgta tcttctatac
     7081 ttcttttcat cgtgttgaaa tcaaatacaa tatacctccg attatcaata aagccaaagg
     7141 cagcagataa ccggacatcg aaccaagcaa cgaaacaatc aggccgatgt tcagcaccaa
     7201 ccacaatccg agcaatacca agccgacgga tttatcccgc ttaataaaca ggaaaatcac
     7261 cgcagtgtaa agcaaaagat tatccttatt catcacccag ggtatcccca aagtggaaaa
     7321 gtgtatcagt ttgtcgatca gatagagcac ccccatcaca ataagggtga ctgctgtggc
     7381 tttgtaggta tctttattgt ttgcttttac cgcactcacc gttacttacc tccgaactta
     7441 ttaatatgga ttttttccca ttgcaaatgg tcttcattaa agggtttacg ttccatccct
     7501 ttatgcccga tcgctatgac ggacaacacc tgcaactgca aaggaatgtc gagcacaccg
     7561 cgcacaaatt catcggaagg tatcccggtg gcagtatatc gctcacgcac ctgcacccag
     7621 caacttccca atcccaagtc ttcggcctga agctgaatca taatagaggc aatggaagcg
     7681 tcctcaatcc atacatcgct cgccaaggga tcggcagtaa cgacaatggc caatgccgcg
     7741 tcggcaataa aggccgaagc ctgctctttg caatgtgaaa gttcactgag caacttttta
     7801 tcatcgactg caataaactg ccagctgtta ctgcgctttg aagtaggagc catcagggcc
     7861 gctttcagca aagcgactac atcttcctga gaaagttctt ctccggtaaa tttccgcatg
     7921 ctgcggcgat tttttattag ttcactgaaa ttttccatgt atctatactt tgcattattt
     7981 gaatataccg ccagtcacca tagaatgcac aaacacacgc gaaccgaggt accgcccggc
     8041 atgcctgtct atataaggta tgccctgcag gactttgcat gaatcggcgc gctccgtggc
     8101 gattcgagcg caaagatagg caatttattc cactctcgtc aactcgccgg tcagtgaatc
     8161 gatgataaaa ccatgcaccc ggacatcttt cggaataagc ggatggttct ctatggaacg
     8221 aaccgtgccc ctgacggact tcaccggatc gtcgaatccg cccagccacg aattaaaatc
     8281 gaccccgcag tagcgtatca tgtcgattgt ttcggacttg attccccgct ttttcatgtg
     8341 agctatcatt tcgtcgctgt tcatgtggca agcaccgcaa tcagaatggg caatgaccat
     8401 cacttcttct actcccaact cgatgatagc caccagcaga ctacggatga cactgccgaa
     8461 aggatgggaa atgacggcac cggcattctt tataatcttt acgtctccgt tgtgaatccc
     8521 caaagcggcg ggcaacagtt ctgtcaggcg ggtatccata caggaaagga tggcgatttt
     8581 cttatcagga tacttgttag tgatatactt ttcgtatccc ctgttctcaa cgaacttttt
     8641 gttgaattca agaatttctt ctaacataat caaaaacgga ttttattgta gtatctccac
     8701 aaagatagtc acaaaacgac agctcaacaa aataagccct gcaaatgttg taaagagaaa
     8761 taaaaaatgt aaatttgtcc cgatatgcca ttaaaactga ctacatatta ccaaggaagt
     8821 gagattccgg attttcccgg aaccaatacg tttcattcga aagagctatt tcagatctac
     8881 gaagaaactc cgggctacac cccactcctg attatggctt cggaagacgg aaaacccgtt
     8941 gcgcgactgc ttgctgccat ccgcaaaagc atccgcatat ttcctcccgc tttcatcaaa
     9001 cgctgcgaaa tctatggcac gggcgaatat ctgatagcgg aagccgacaa ggaaaggata
     9061 ttcggcgaaa tgctggagca cctcaccacg gaggctttgc ggaactcgtt tctaatagaa
     9121 ttccgcaatc tggagaacgc catgttcggc tacaaatatt tccggtccaa cagatacttc
     9181 cctgtcaact ggctgcgggt acgaaactcg cttcacggca tcgaaaacgc cgaacagcgt
     9241 ttcagcccct cccgtatccg ccagatcaaa aaaggcctga aaaacggagc aaaagtagac
     9301 gaggcacgta cggtagaaga gatacgcgaa ttttcgaata tgctgaggca tctctattcg
     9361 tcccgcatcc gtaaacattt tcccaacatc atctttttcc aacacatgga cacccggctg
     9421 attcacagcc ggcaggcaaa gattttcatc gtccgctaca aagacaaaat tatcggaggc
     9481 tctgcctgta tctattcggg aaacgatgcc tatctctggt tttcgggagg tatgcgaaag
     9541 acctatgcct tgcaataccc gggtatactg gctgtatgga aagccctcca ggatgcccat
     9601 caaaacggat tccgtcacat ggagttcatg gacgccggac tcccatttaa gaagcacggc
     9661 tatcgtgact tcgtgctccg cttcggtggc aagcaaagca gcacccggcg atggttccgt
     9721 ttccgctggc aatggctgaa cgacctgctg atcaaaatat acgtctgaac atccgcctgt
     9781 ctcagggatc agcgccaacc ctctccgtct tttaaaccac cccccttagg ttttaaacca
     9841 acgatacctg ccttttaaac ccatgcacct taggttttaa acctattttc accataatta
     9901 attgcagaaa aatttcttta ttaaacaaga attgattttc tttgtgctgt tttataccat
     9961 tccgaaaaga cgattaatac caaaatttaa aaatatagtt atgaagattt cacacattga
    10021 acatttgggc attgccgtaa aaagtatcga agaagccctt ccgtattatg aaaacgtttt
    10081 aggtttgaaa tgctacaaca tcgaaactgt agaagatcaa aaagtaagaa cagccttcct
    10141 gaaagtaggt gataccaaaa tcgaattact ggaacccaca tgtccggaaa gtaccatcgc
    10201 gaaattcatt gaaaacaaag gtgcaggtgt tcatcacgta gcattcgcca ttgaagacgg
    10261 cgtagccaat gccctggccg aagccgaaag caaagagatc cgcctgatcg acaaagctcc
    10321 gcgcaaaggt gccgaaggcc tgaacattgc tttccttcac ccgaaatcaa ctctgggcgt
    10381 actgacagaa ctctgcgaac actaaaaaga tgtacgattc ggacgatccg cgccacggac
    10441 aaacggaatt tttctttgca ttaaattccc catccgggtt gtcaatcgtc ctgttgtaaa
    10501 tattataacc ctttaaatta agaaaaactc atgagtaacc agcttgaaaa agtaaaagag
    10561 cttattgaac ttcgtgctca ggctcgttta ggtggtggcg aaaaggctat tgaaaaacaa
    10621 cacgccaaag gcaaatatac agcccgcgag cgtattgcac agttgcttga cgaaggtagt
    10681 ttcgaagaac tggatatgtt tgtccaacac agatgtacca atttcggaca agagaaaaaa
    10741 catttcctcg gcgacggtgt ggtaaccggt tatggaacga tagaaggtag attagtatat
    10801 gttttcgcac aagatttcac agtattcggt ggttcactgt cggaaaccat ggcacaaaag
    10861 atctgtaaag taatggatat ggccatgaag atgggtgccc ctgttatcgg tatcaacgac
    10921 tcgggtggcg cacgtattca ggaaggcatc aacgccctgt ccggttatgc tgaaatcttc
    10981 cagcgcaaca tcatggcttc gggtgtcatc ccacagattt caggtatttt cggtccgtgt
    11041 gccggcggtg cggtttactc tcccgccctg acggacttca cgctgatgac ggaaggtaca
    11101 tcttacatgt tcctcaccgg accggctgtt gtgaaaacag taacgggtga agacgtgtct
    11161 caggaagatc tgggtggtgc aagcgtacat gccagcaagt ccggtgtaac tcacttcact
    11221 gccgaaaccg gtgaagaagg tctggcgatt attcgcaagc ttctcagctt tattccgcaa
    11281 aacaacctgg aagaagctcc attggtgaac tgtaccgacc ccatcgaccg tatggacgac
    11341 ctgctgaacg agatcatccc cgacagcccg aacaaaccgt acgatatgta cgaagtgatc
    11401 ggcgccatca tcgataacgg agaattcctg gaagtacaga aagactatgc gaaaaatctt
    11461 attatcggtt ttgcccgtat gaacggacaa tcggtaggtg tggttgccaa tcagcctaaa
    11521 tacctcgccg gagtactcga cagcaatgct tcacgcaaag gtgcacgctt cgttcgcttc
    11581 tgcgacgcat tcaacattcc gctggtgaca ttggtagacg ttccgggatt ccttccgggt
    11641 acgggtcagg aatataatgg tgtaatcctt cacggagcca agttgctgta cgcttatggt
    11701 gaagccactg tgcccaaggt aactgttacc ctgcgtaaat cttacggtgg ttcgcacatc
    11761 gtaatgagtt gcaagcaact ccgcggcgac atgaactatg catggccgac agccgaaatc
    11821 gccgtaatgg gcggtgccgg tgcagtagcg gtattgtatg ccaaagaagc caaagatcag
    11881 gaaaaccctg ctcaattcct ggcagacaag gaagccgagt acactaaact gttcgccaac
    11941 ccgtacaatg cagccaaata cggttacatc gacgatgtta tcgaaccgag aaacactcgt
    12001 ttccgcgtga tccgcgccct gcaacagctg cagaccaaaa aattaaccaa ccctgctaaa
    12061 aagcacggta atattccatt gtaacaaatt aaacatcgat tgttatgaat aagaaaagaa
    12121 tcgggatatt tatcgctctg ctggcaatgg tttgcatggg gctcagggcg caaagtgcca
    12181 ccagtctgag aatcaatgag gttttggtcg tcaacgacca gaactatcag gatgactacg
    12241 gactgcacaa tgcgtggata gagatattca acacctcttt cgcttctgta aatctggaag
    12301 gttgctttct gacgaacgat aaaaacaatc cgaccaaata tcctattccc aaaggcgacg
    12361 tgctgactct gatcaagccg cgccaacatg ctttgttctg ggcagacgga atgcctaacc
    12421 ggggtacgtt ccacgtgaac tttacgctcg acccgaacaa agagaattac attgctttgt
    12481 atgactctaa cggtaaaact ctgattgacg aagtaaccat acccgccggt cagcttgccg
    12541 accgttcata cgctcgcgaa aaagacggaa gtgccaactg ggtagtaaaa ggtgaaggag
    12601 aacacagcta tgtcactccg agcaccaaca atatgactat cgacaaaaac ccgaagatcg
    12661 agaacttcaa gaaacacgac tctatcggta tcggtatggc catcatcgcc atgtcggtcg
    12721 tattcatagg tttggtactc ttgtatcttt cattcaaggc ggtaggtaac gtagctgtca
    12781 gactgggtaa gaaaaacgcg atgaaagcca ccggtatcac cgacaagacg gaagcgaagg
    12841 aaaagaacct gggtagccac acaggtgaag aaaccgccgc gatcgccatg gctttgcatg
    12901 aatacctgaa tgacgctcac gacgttgaag acatgatttt gactatcaac aaagtgaaac
    12961 gcacctactc cccctggagt tcgaagatct acacactgcg tcagactccg aaaagataat
    13021 tactaaccct aataaaatga agcaatgaaa caatataaat ataaaatcaa cggcaacctt
    13081 tacaacgtta cagtgaacga tgtagaagat aacatagcca acgttgaagt gaacggaacc
    13141 tcttataaag tagagttgga caagcctgtc aaagccgctc cgaaaccggt gacccgtccg
    13201 gcagccgctc cgaaaacgga aacaggtgct ccggtagtaa ccaaacaacc gacagcttcc
    13261 aaaaaagacg gtgtgaaatc tccgcttccg ggcgttatcc tcgacataaa agtgaaagaa
    13321 ggggataccg tgaagagagg ccagacgatc atcatccttg aggctatgaa gatggaaaac
    13381 aacatcaatg ccaataaaga cggaaaagta gcagaaatta aagttaataa aggagattct
    13441 gtacttgaag gtacagacct cgtaatcatt gaataattat gggagatttc gtatcattct
    13501 tagggaataa ccttgttgac ttctggggat acaccggttt tgcgaacgcg acacccggac
    13561 atcttttcat gttgctaatc ggtctcttct ttatctacct tgccgtagcc aaagaatttg
    13621 aaccgatgct gctgatcccc attggcttcg gtattctgat cggtaatatt ccattcaata
    13681 tggaagccgg attaaaagtg ggtatttacg aagaaggttc ggtactgaac atcctttatc
    13741 aaggagtaac ctccggctgg tatccgccgc tcattttcct gggtatcgga gccatgacgg
    13801 acttctcggc gctgatctcc aaccccaaat tgatgctgat cggagctgct gcgcaattcg
    13861 gtatcttcgg cgcgtatatc attgccctgc tcattgggtt cgaacccaac caggcgggtg
    13921 ctatcggtat cattggcggt gccgacggac cgacggccat cttcctttcg tccaaactgg
    13981 ctcccaacct gatgggtgcc atcgctgtgt cagcctattc ttacatggcg ctggtgccgg
    14041 tgatacagcc acctatcatg cgtgcgctaa ccaccaaaca cgagcgtctg atccgcatga
    14101 aaccaccgag aatcgtatcg catacggaaa aagtaatctt ccccatcgtg ggtctgttgc
    14161 ttacatgctt cctggttcct tcgggtctgc ctttgctggg tatgctgttc ttcggtaatc
    14221 ttctgaaaga aagtggagta acccgtcgtt tggcaaatac ggccagtggt ccgttgatcg
    14281 atgtgatcac tatcctgttg ggactgactg tgggagcttc tacccaagct tcacaattcc
    14341 tcacctggga ttctatcttg atctttatcc tcggtgcatt ctctttcatc atcgcaacag
    14401 cgtcaggtgt catgtttgtc aaattcttca atctattctt gaagaaaggc aataagatca
    14461 atccgctgat tggtaatgca ggtgtatccg ccgtacccga ctcggcacgt atttcacagg
    14521 taatcggttt ggaatatgat ccgaccaact atctgctgat gcacgccatg ggtcctaacg
    14581 tagcgggggt tatcggttcg gctgtagctg ccggtatcct gctcggattc ctcatgtaaa
    14641 cgatattttt ttcattagta aggtagacgc ccttcttttc gcaaagaagg gcgtcttttt
    14701 tttgcgttaa tctatctaaa agacattacg aacctttcgt agaatggata tttttactaa
    14761 cttgcggaca ataaaacaat acgtcctatg agaacaagaa caatgaaacc actcttcctt
    14821 attttctgtc tttgcctcag tcccctactg atgggccaga atcaaaacaa aattcaggaa
    14881 gcaatggcaa actatgacta cgagactgcc gttgaactga taaacaagga acctcccacc
    14941 atcccactgt taatgcagaa agcaaaagcc ctgaaaggaa tcggcagcaa tgcggaagct
    15001 ctacgttcca tccgccaagt gatagcggaa gactccacca accaacaggc acacatcgaa
    15061 gcagcggaat gctgtaaagc aatggccaag tacaacgatg cgctggacta ctaccggaaa
    15121 gccatcagcc tgaatcccaa aaacaagtat gcccgtttgc aattcatcaa cctactttgc
    15181 aacaccaaaa actatgctga agcttttgga gaaagttcaa tgatgtccga aacggacagt
    15241 tcggccgtag tgctccacct acaggctcaa agccttgaag ggatgcaaca gatactaccg
    15301 gctatcggtt gctatgaagt cattcaggat aaatatccgg acgattatct ggctgcggcc
    15361 aaactcggaa acctgaacat tgtagctgga tatcccgaat atgccatcca agctaccgaa
    15421 cgctataggg aacgggactc caccaacctg attgtcaacc agcaaaacgc tctcgcctac
    15481 tgccacgccg aacaatatcc gacagccatc aagcgctatg aaaagctgtg ccaacagggg
    15541 gacagcagta cacagacctt atactatctg ggagtcagct attacgcgga tgaatattat
    15601 tacgaagcgc acgcgtgttt cagcaaactg caaaaagaga tggaagaaaa tcccaatctg
    15661 ctctattatc tgggacgttg ctgcgccaag acttcctgga aaaaagaagg catcgaacac
    15721 ctggagaaag ctatcgaact aaccattccc aaagacagca ccatgatccg actttacaaa
    15781 ggcttggtgg attgttgtaa actggctcag gatactccaa agcaaatcca ggctctcaga
    15841 gaactgtaca aatatgacaa gacgaaccat aaacttcttt atgacatcgc ctggaactat
    15901 tcatatcaac tcaaagacaa caaatcggcc gaacgttatc tgcaggcttt cttaaaaacc
    15961 cgaaaggcga atgccaggaa agaagaaccg gtgagtgaga aaggggaact tgtactcgga
    16021 cttgaaaatt attacaacgc tgccgaaaat tggctgaaag acttacagaa agaaaagttc
    16081 ttcaaagaag gaataccgtt agaaagtcag aaacaataga atctgtcccc ccatgaaaca
    16141 ttggatactc ctcctctatc tgggcttcag cgtaatgctg cgagctcaga acaccgcctc
    16201 cgttcaagaa gcaatggcaa actatgacta taaaacggtg atcagactga ttgatgaaga
    16261 aagtgcatca ccacagttac tcatacagaa agccaaagct ttaaaaggtt tagggcgtac
    16321 cgccgaagcc ctgtccactt tgcaacatat cattatcgag ctgcccgaaa atcagcaggc
    16381 attggtagag gctgcagaat gttgcaggca attgagcaaa tttaacgagg ccttggggta
    16441 ttatcggaag gtgatggaac tcaatcccga acatatttac gcacacttgc aatacacccg
    16501 cttgttatac aactatcagc gatacggcga tgcattgcgt gagagtatcg cattggccag
    16561 gaaagacagt tccgccaccg tattgcgact gatggcggaa agcatggaag gagccggcat
    16621 gccggtagaa agtatgtttt gctatctttc catcatcagg aaatatccct ccgactatct
    16681 ctcggtagct aagctgggca gtatcttcaa tacaatgaaa gattacgaag gggcaattgc
    16741 cctgacagaa gcataccgcc ggacggacag caccaatgta gaagtgaacc gtcaaaacgc
    16801 actggcgtat tgtctgcgca aagaatatcc caccgccatc aaacgttatc aggatctgac
    16861 cgcccgggga gacagcacac tgctgacatg ttattacctg ggagtcagct actacgctac
    16921 gaaagaatac tataaagcgc gcgattggct gctcaaagca aaatcatgcc agtcacccgg
    16981 cgccaaccta ctctactatt tgggacgttc gtgctccaag acattatgga aacaagaggg
    17041 aataggatat ctgaaccagg ctatcgccct gactatcccc gccgacagta tcatggagcg
    17101 cttatactca ggcttggcag actgctacag gcaaaccaag caaatccggg accaaatcaa
    17161 ggctaccaaa gaacaataca aatatgcccc tgacaagcat attttacttt ataacttggc
    17221 gttcttatcg gacaaaattg aagatactaa agccacagag cattacttgc aggcttttct
    17281 gcgaacaaaa tccaaacaaa atgcagtact acagcagccg gatgatgacg aagaagaacc
    17341 cacaccctac atagattact acaaaagtgc caccaataaa ttggaaagca tccgaaaaga
    17401 gaaattctta aagggagaaa agtgaattga tcggatagat gcatcgtttc ggacaattca
    17461 ccactgagtg cagacagagt ttcacagagg gagaataatg gaaaataaat ttgaagatgt
    17521 gcggtagaag gcacagtggc acgtaaccga agtcacatcg gcacgcagcc gaaattacgg
    17581 tgctgtgtag ataaagttac ggtgctgcgt agccgaagtt acggtgctgc gtagccgaag
    17641 ttacggtgct gcgtaatcaa agttacggtg ctgcgtaatc aaagttacgg tgnnnnnnnn
    17701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnggtgctgc gtaatcaaag ttacggtgct
    17821 gcgtaatcaa agttacggtg ctgcgtaatc aaagttacgg tgctgcgtag ccgaagttac
    17881 ggtgctgcgt agccgaagct atgacggcat ctccttttcc ggacgtcacg ttcacctgat
    17941 tgcatcgaaa agtgctcctt atcggttgag ctccatcccg gagaattctc caatgaaaac
    18001 gtttgcataa atagatggca cacagtaaga aagaaaacgg aaaacaatcc gatgatttac
    18061 cctatattag caacattaaa taataacgag ctaatatcat gaaaaaatta ttgttactct
    18121 taggttcatt cctactgtca ttaaccactt atgcagccat gaacatatcc aaaatcgatc
    18181 cgcccttctg gttcaccggt atgaacaatc cggaactcca gttaatggta tacggtgaag
    18241 gcatcggcca ggcatccgta tcagtaaatt atcccggtgt atcgctcagc agcgtcgtga
    18301 aactggaaag caacaattac ctgcttgtct acctacatct cgataaagaa gtaaagccgg
    18361 gcaagatgcc catcacattt acggtcggaa agaagaaatt ggtgaaagag tacgaattga
    18421 aagcacgcag caaagccgga gtcgatcaca aaggttttga cgtatcggat gcattatacc
    18481 tgctgatgcc ggaccgtttt gccaatggca atccggataa cgaccggata gaaggcatgg
    18541 ccgaatataa agtggaccgc aacgacccga acgcacgtca cggaggcgac ctggccggta
    18601 tcgaacaaaa tctggactat tttaccgact tgggagtgac cgcactctgg ttcaccccgg
    18661 tactcgaaaa taatatgaaa ggcggctcat atcacggata tgcaacaacc gattattaca
    18721 aggtagaccc acgtttcggc actaacgagg aatatcgctc actgatagcg aaagcccaca
    18781 accggggcat taaggtcgtg atggacatga tcttcaatca ttgcggagta gaacatccct
    18841 ggatcaagga catgccttca aaggactggt tcaaccatgc ggacttcaag aacaactttg
    18901 tgcaaacttc ctacaagctg actccacatg tagatccgta tgcctcggag tacgatttcg
    18961 accagatgaa caacggctgg ttcgtggaag ccatgcctga cctcaaccaa aagaaccctc
    19021 acgtatacaa atacctcttg cagaacagcc tgtggtggat tgagtacgcc gatatcgacg
    19081 gcatccggat ggacacctac ccgtatgccg attacgatgc catgagcaac tggatgaaag
    19141 aactgaacga agaatacccc aactacaaca cggtgggcga aacctgggtt accgaaccgg
    19201 cctatacagc ctggtggcag aaagactcca agctctccgc cccgcgcaac agtcacttga
    19261 aaacagtcat ggatttcagc ttcttcgaca aagtcaacac ggccaagaat gaacaaacgg
    19321 acacttggtt caaaggattg gaccgtgtct acaacaattt tgtatacgat tatctgtatc
    19381 ccaatccggc ttccgtactg gctttcatcg aaaatcatga caccgaccgt ttcttgggtg
    19441 aaggcgaaaa cctcgatatg ctgaaacagg cctccaccct tttattgacc acccgacgca
    19501 tcccgcaact ctattatgga acggaggtga tgatgaacgg agtaaagagt aaaagcgacg
    19561 gctatgtacg aaaggacttc ccgggcggat gggcggacga taaagagaat gccctgactc
    19621 ccgagggacg tacccgattg cagaatgaaa gctataactt ctaccgcaac ctgctgaact
    19681 ggcgtaaggg caacgatgtg atcgccaaag gcagcatgaa acagttcatg gtacagcacg
    19741 gcgtatatgc ttatgcacgc caatataaag ggaaaacggt attcgtcctg ttgaacggta
    19801 cggataaaga agtgaaactt cccctgaaat actatgccga agtgctgaaa gacaagactc
    19861 aaggaaaaga cgtcattagc ggaaaagtaa cggcactcaa tgaagaactg acaatggcac
    19921 cccgccaatc gatggttata gagctttaat ctcacaccgg ttataaccgc ataagcaaag
    19981 ggcacaaagg atttcacccg acatcctctg tgccctttgt gtagcctaat gcgaataata
    20041 atagtcaaac atttgactat tatcggagaa tattcctacc tttgcagcga ctaaaagaat
    20101 acgacgatga caaacaacga atcggagcgc gagctcgtcc tacaaacctt acgaacctgg
    20161 atggcattcc gccaggccgt tcagcgggta ctcaaacgcc acaacgtgga tatgaccttc
    20221 gagatgctgc aagtaatgaa ctgcctgtgg aacaaacaag gcatcagcca gcaatccctg
    20281 gctgagaaaa cagcaaagga caaggcttgc ctgaccaatc tgattaataa tctggaaaag
    20341 aaaaactggg tgatacggaa agaaggcccc tccgaccgcc gaaaccgcct gattttcctg
    20401 acgccccaag gcgaagaact tgccctcacc gtgaaacccc tgatcaacga tatctatgcc
    20461 caaaccggag cagagatgga ggcaagccgg ataacggaat gcatcgaaga cctgaagaga
    20521 ctgcatgaag tgctcaatga gatctaaaag aaatccgcca tgtccaccca tcagataaag
    20581 ctaaaacaat tgagaagact gaagttcagg aacatctttc tcaacacagt atgcatcctg
    20641 ctggcattgg caggtatttc atggacagta aactacttct ggaaatacgc ccgctacgag
    20701 ataaccaatg atgccgtagt ggatcaatac atcgctccgc taaacatccg gataccgggc
    20761 tatatcaaag aagtacgttt taccgaacac cagtatgttc atgccggcga cacgttactg
    20821 atactggacg accgggaata ccggatccgg ctgaaagacg cggaagcggc cttgatggat
    20881 gccttgggat caaaggaagt gttaaactcc ggcatccgga cttcaggagt aaatgtagcc
    20941 gtacaagaag ctaacatagc cgaaacactg gcacgccttt cacaacaaga agcggaactg
    21001 aaccgatata cccggctcct gaaaaagcag gccgtcagcc aacaggatta tgaactggcc
    21061 aaagcgaact tcgaagcgac tcaggcaaga tacaacgccc tgttgcgaca aaaagaagcg
    21121 gcccaatcgc agtattccga aaccagcaaa cgcagtacag gcgccgaagc caatatcctc
    21181 cggaaggagg ccgacctgga gatggccaaa ctaaacctgt cgtataccgt tgtcaccgca
    21241 ccctatgacg gatacacggg acgacgtaca cttgaaccgg gacagttcgt acaaggcgga
    21301 caaactcttt cctacctggt acggggcaat gacaagtggg tgacagccaa ttataaagag
    21361 acacaaatag cccatatcta tatcgggcaa aaagtccgca tcaaagtaga tgctttcagc
    21421 ggacgcactt ttcacgggac cgtaaccgcc atttccgaag ccaccggatc gaaatactcc
    21481 ctggtaccga ccgacaattc ggcagggaac ttcgtcaaag tgcagcaacg cattccggtc
    21541 cgcatcgatc tcaatgacgc ctcacccgaa gagatggaat gcctccgtgc agggatgatg
    21601 gtagaaacgg aagcggtccg cccttaggct tatggtgaag ctcaatctgc ctacccgtcc
    21661 ctgggtgcct caatggttgg gcatcgtgac catgtttatt gtcatctttc ccatcaccct
    21721 gctcaacggt gcctacacag gaagtatggt cgaagtatcg aacacgctgg gagtattgag
    21781 cgaagatatt accatggctt actattcagc ttcggtaggg atggctgttg cctatcccat
    21841 cgtaccgaaa atacgcacca tagccactcc gaaaacctta ctgctcactg acctgctgct
    21901 acagatattc ttcagcctgg tatgcgccaa aaccggtagt atggacgtca tcatggtatg
    21961 cagtttctat atgggatttc tcaaagcctt cgtcatgttg gagttcatca tcctgatccg
    22021 cccgctcttc agtccgaaaa acgtacgaag tgaattctat gcctacttct accccatcgt
    22081 tttctccgga ggtcagctat cgatggctat caccgctcaa ctggcctatc actaccaatg
    22141 gcagcacatg tactattttg tcaccatcct cttgctgatc gcccttctgt tcgtcatctg
    22201 tttcttccgc tatgcaaggc gtcccatgca cattccgttc aaagaaatgg acggaagaag
    22261 catgttcatc atcgccaccg ctttcctgct aacgctctat acatttacct acgggaaaac
    22321 actcgattgg ttcgcatccc cgaagatcag agtatatgta ttcgtcatcc cgctcctgat
    22381 agttctcttc atccatcggc agcgtacaca aggcaaaccc tttgtcagcc tgaaaccact
    22441 ctttctgcat aaatccatca tcggatatgg cttcatggta ctcgccatgt tcctgacagc
    22501 caccagttca ctggtaacca actatatgaa cagcatcatc cgggtagaca gcatacacgc
    22561 caattcgctg agcctgtggc tattgcccgg atatgtggta ggagccgtca tttgcttctg
    22621 gtggttccga tggcaacgat ggcggtttcg cttcctcatt tcaggaggta tgttctgcta
    22681 cgtcatctat ctggctatcc tctactttgg tatcacccct tatggaactt atgaaatgct
    22741 ctacctcccc atcctgttcc ggggagtggg gatgatggtc atattcattg cgttcggtgt
    22801 gtttgttgtc gaagatttag acccgcgcct gacgttgtcc aatgccttct tcctgatttc
    22861 attccgctca gtattagctc cggtcctatc cgcttcgttc tttaacaaca tgctttacta
    22921 tctgcaggca aaggggatga acattctttc ggaaaacatg acgctgacca atccgctggc
    22981 cgaacaaaaa tacaatcagg cattgagcaa tgccctggcg caagggcacg aattcagcga
    23041 ggccggacaa ttggcagcca acagcctgta ctccactttg cagcagcaat ccctgctgct
    23101 tgccctgaaa accctaatcg gctatgtact gatactggca ctggtgattg ctgtcatcgc
    23161 agcgttcatt cctttccata aaacgctgaa ggtggctgta gtgaagacgg gtgacgatat
    23221 ggtataatga gaagggatac aaaaaagcca cccaattgct tgagtggctt cttaaaatat
    23281 aaattaaatc aagtaaaact tttaaatact agatttggaa tttattcagc taacttgttg
    23341 tcagaaccca gcacgttgat aattttgtgc ttgtagagtt tttccatatt gtcgcgagcc
    23401 ggtcccagat atttacgcgg atcgaactca gccggttttt ctgcgaatac cttacggata
    23461 gcagcagtca tagccaggcg agagtctgag tcgatgttga ttttgcaaac agcagactta
    23521 gcggctttac gcagttcctc ttcaggaata ccgatagcag ctttcagtgc accaccaaac
    23581 tggttgatag ttgcaacctc ttcttcagga actgaagatg atccgtgaag aacgataggg
    23641 aatcccggaa gttctttcat tacaccgtcc aatacgtcga atgccaacgg aggaggaacc
    23701 atacggcctg tcttcggatc gatgtggcac tgttccggag taaatttgta agcaccgtga
    23761 gaagtaccga tagagatagc caatgaatcg caacctgtct tggtaacgaa atcaactact
    23821 tcgtccggtt cagtatatgt gtggtggtca gaagaaactt cgtcttctac acctgccaat
    23881 acgccaagtt caccttctac agttacatcg aactggtgag cgtattcaac aactttctta
    23941 gtcagagcaa cgttttcgtc gtaaggaagg tgagaaccgt cgatcattac agaagagaag
    24001 cctgagtcga tacagctttt gcaagtttcg aaagtatctc cgtggtcgag gtgcaaaacg
    24061 atttcaggat ttttgcagcc gagttctttt gcatattcta cagcaccctg agccatgtaa
    24121 cgcaacaatg tagcgttagc atactgacga gcaccttttg aaacctgcaa aataaccgga
    24181 gattttgttt ctactgcagc tttgatgata gcctgcatct gttccatatt gttgaagttg
    24241 aatgcaggaa ttgcatatcc acctttgata gccttagcaa acatatctct agtgtttacc
    24301 agacctaaat ctttgtaatt aaccattttg tttaaaagtt tattgttagt gaattaaaaa
    24361 ttctatgcaa aagtaagaat aatcctttga atagagaaac cctcgggcgg aaatatccgt
    24421 ttgaggagcg taattcaatt ctatttcaaa ttatttccca tcctttaaga gctgtttgta
    24481 atgtctacgt agcaaataaa ggttttttat tgtttcctca tatatataat ggtaggcaaa
    24541 tgatcgctgt aaccatccaa ccacactctg ccaccatatg tacgcagggg tgcaccctta
    24601 tatttaccat cctgctgaaa caggtaatcg cgcatgaaa
//
