LOCUS       c00172_gnlPro..        16114 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HNDMMMFM_172.
ACCESSION   c00172_gnlPro..
VERSION     c00172_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:01:37
            Original ID  :: gnl|Prokka|HNDMMMFM_172
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16114
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16114
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1721:6283]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1722..6283
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16114
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16114
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..94
                     /locus_tag="ctg172_1"
                     /transl_table=11
                     /translation="KYLGPARDNMEKLYKHKILNVLGSDNKLAE"
     CDS             complement(174..1508)
                     /locus_tag="ctg172_2"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIITNDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQIDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLLYYLGRACAKTSWKKLGVEYLEKALDLTIPKDSNMVRLYIGMTDCYKMAQMPKE
                     QIESIRERYRKYDKQNHKLLYDMAFIYFYSLKDKKNTERCLEAFLKTRPKEDKEEEAKL
                     NERGELVLGTKNYYNAAANWLKDIQSKQKIEDFFLGGNVPAQKPE"
     CDS             complement(1722..2882)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_3"
                     /sec_met_domain="OAD_beta (E-value: 1.7e-153, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATGGHIAMIIIGLGFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(2884..3318)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1e-21, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKAT
                     PKPAVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             complement(3343..4263)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_5"
                     /sec_met_domain="OAD_gamma (E-value: 4.5e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             complement(4295..5848)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_6"
                     /sec_met_domain="CT_Btheta (E-value: 1e-290, bitscore:
                     954.3, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(5879..6283)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_7"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.7e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(6457..7455)
                     /locus_tag="ctg172_8"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             7704..10898
                     /locus_tag="ctg172_9"
                     /transl_table=11
                     /translation="MRENAFVEAWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     MGARVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNNQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWINAGINVQA
                     SFSNKNSRNAVLERALFATPLGVPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLEWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKAHDLTITGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYNIPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYY
                     VDGSFFKLKNVTLGYTLPGKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSI
                     NFPLSRDCIFGLNLTF"
     CDS             10910..12865
                     /locus_tag="ctg172_10"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDENEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYIFDEYARELCGECGRWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             13052..13594
                     /locus_tag="ctg172_11"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(13708..13893)
                     /locus_tag="ctg172_12"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIKEHGHPVCYKRVHESKKVYNRR
                     KIKAADKKLPYFFHLG"
     CDS             13993..14529
                     /locus_tag="ctg172_13"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDEVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEKLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             14532..14867
                     /locus_tag="ctg172_14"
                     /transl_table=11
                     /translation="MGAVKANNNKDTYKATAVAFIVIGTLFLINKLLPFASIGLPWVMN
                     KDNLLLYASISFLIFKRDKSVGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLALLIIGII
                     LFWVSKR"
     CDS             14875..15669
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Shikimate_DH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg172_15"
                     /sec_met_domain="Shikimate_DH (E-value: 6.8e-11, bitscore:
                     32.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="F420_oxidored (E-value: 3.8e-13, bitscore:
                     40.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPVVFLGAGNLATNLAKALYRKGFRIMQVYSRTEESAR
                     TLANEVEAEYITDLKGVSNEARLYIISLKDAAFVELLPQITDGKQHALLVHTAGSIPMN
                     IWEGHAERYGVFYPMQTFSKQREVDFREVPFFIEAKRPEDAELLKAVAGTLSDKVYEAD
                     SEQRRSLHLAAVFTCNFTNHMYALAAELLEKYHLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNKHLSMLADSQALQEIYKLMSKSIHEHHQL"
     CDS             15650..16114
                     /locus_tag="ctg172_16"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFAALGVKDLYMGSAVKIHDYRDFRDKYGLSDDE
                     ILYMGDDVPDIEVMRECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVV"
ORIGIN
        1 taagtatctt ggtccggctc gtgacaacat ggaaaaactg tacaagcaca aaatccttaa
       61 tgtgctgggt tcagacaaca aattggctga ataatcacag attatcctat tatatagaaa
      121 ggctgcaatc gtttgacggt tgcagccttt tttacgtaat atcctttatc tgcttattcc
      181 ggtttctgag cgggcacatt tcctcccaag aagaaatctt ctatcttttg cttactttga
      241 atgtctttca gccagttggc tgcagcatta taataattct tagtgcctaa aacgagttcg
      301 cctcgttcgt ttagtttcgc ttcttcttcc ttatcttctt tcgggcgtgt ttttaagaat
      361 gcttccagac agcgttcggt gtttttcttg tctttcagcg aatagaaata aatgaaagcc
      421 atatcataga gcagcttatg attttgttta tcgtatttcc ggtagcgttc tctgatcgat
      481 tcaatctgct ctttaggcat ctgtgccatt ttgtagcagt cggtcatgcc aatatagagc
      541 cgtaccatat tactgtcttt gggaatagtc agatcaagcg ctttttcgag atactctacg
      601 cctaacttct tccatgaagt cttggcgcag gcacggccga gataataaag caggtttacg
      661 ttttcaggat catgttttcg ggcggcttcc agaaagtcat gtgcttcgta atatttctct
      721 tccgcataat agctgatacc cagataataa caggtatgaa aagaactgtc gccctggctc
      781 accaggtatt cataacgctg gatagcggta ggataatcct tattcagaca atatgccagt
      841 gcattctggc ggttgacagc gatgttggtg gtgtcaatct gccgatattt ctccgtggct
      901 tcaattgctt cgttgaaata agaaccggct atgttcagtg cggcgagctt ggcggcggca
      961 agatagtcgt cggggtattt ctcctgtata ttatagtagc accccgtggc ggggagaagc
     1021 tctcccatac cttcgaaact ttgggcctgc agatgcaagg cgatggcgga actgtctttc
     1081 tctgtcatca gactactttc tcctaaagca tcctgaaact tctgtaaaga gagcagtagt
     1141 ccgatgtatt gaatacgcac atatttgttt tccggattca gatcaagtgc ctgttcataa
     1201 tatttcagtg cctgttggta tttggccaat gaacggcagc attcggctgc ttcgatatat
     1261 gcacgggtat tggcagtgtc attggttatg atttcctgat aagtggaaag tgcttctgta
     1321 ttcatcccaa gtccccgttg tgctttacct ttttgcaaga gtaggggaat tgtcggcttt
     1381 tctttggcaa tgagagtgag agctgcctcg taatcgtagt ttgctattgc ttcctgaaca
     1441 tgattgatgc gctgcgccat caccagggtg gtggtacaaa ggaaggcgag gagaataatc
     1501 cgtttcataa atatttattt tagtgtgtcg taacaaagac gcaagatgct aaaaaatatc
     1561 gtatttacga attattcgta gcctttttgg aatagattaa cggaatgata agagaagata
     1621 acataatgat aagtgcggat attgcatcta aaacagcaat atccgcacct aatattttgt
     1681 cccggcattc cgaatggaag cctgacaggg gcaccttgtc cctacattaa gaatcctaac
     1741 aggataccgg cagcaacagc tgaaccgatt acacctgcta cgttcggacc catagcgtgc
     1801 atcagcaagt agttggttgg atcatattcc agaccgacaa cttgtgagat acgtgcagag
     1861 tcgggaacgg cagatacacc tgcattaccg atcaacggat tgatcttatt gcccttcttg
     1921 aggaagaggt tgaagatctt aacgaagatc acacctgatg cggtagcaat gataaatgac
     1981 agtgcaccga gggcaaagat cttgatggag tcgagtgtca ggaactcgga agcctgagta
     2041 gaggcaccta ctgtcaaacc taacaggata gtgataacgt caatcagcgg accgctggct
     2101 gtgttagcca gacgacgggt tacaccactt tctttcaaca ggttaccgaa gaacagcata
     2161 cccagcagag gcagaccgga aggaaccagg aagcaggtca gcaacagacc gataatcggg
     2221 aaaatcactt tctctgtatg agaaacggca cgtggcggtt tcatacggat aacgcgttcg
     2281 tgcttggtgg tgagcagacg catgataggc ggctgtatca ccggaactaa cgccatataa
     2341 gagtaggcgg ataccgcaat ggctcccatt aagttaggtg ccagcttgga cgaaaggaag
     2401 atagccgtcg gaccatctgc tccaccgatg ataccgatag caccggcctg catcgggtca
     2461 aatcccattt ccaatgcaat catgtatgca ccgaagatac caaactgggc ggccgcaccg
     2521 atcagcatca gcttcggatt ggagatcagt gccgagaagt ctgtcatggc accgatacct
     2581 aagaagatga gcggtggata ccagccggac gttactccct gatacaatat gttcaataca
     2641 gaaccttctt catatatacc gacttttagt ccggcgtcca tattgaaagg tatattaccg
     2701 atcagaatac cgaatccgat aggaattaac aacatcggct cgaactcttt ggctacagct
     2761 aagtaaataa agcctaaacc gataatgatc atagcaatat gtccacctgt cgcgttggca
     2821 aatcccgtgt aggtccagaa atcggcaagg ttatttccta aaaagttaat aaaatctccc
     2881 atattattca ataattacga ggtcattacc ttcaagaaca gaatctccct tgttgacatt
     2941 gatggcagtc actttaccgt ctttgtctgc attgatattg ttttccatct tcatggcttc
     3001 caatataatg atagtctgtc ctctcttcac tgtatcacct acatttactt tgatgtcaag
     3061 gataacgcct ggcagcgggg acttaacgcc cgatttgccg gtagaaggag cagccggttt
     3121 tactaccggt gtggtaggag cagccggtga gttaggcata gggcgtacta ctgccggttt
     3181 gggagtagct ttcggttgtt tctccatttc tactttgtaa tgcgtaccgt tcacttctac
     3241 atgagcgata ttatcttcaa tatctccgat ggttactttg tatgagttac cgttgatttt
     3301 atatttatat tctttcatcg ttttattttt ttagggaatg atttactttc tgttaggatt
     3361 ttcacgcaag gtgtaaatct tcgaactcca cggtgaataa ctgcgcttca cacgagtgat
     3421 ggtcagcacc gtttcttcta cgtcatgtac ctcatcctgc atttcgtgta atgccattga
     3481 aatagcagca taaacttcac ccggagcctg tgaaagctct ttcgcttcga ctttatcgat
     3541 gcctttagcc ttcatcgcat tgcgtttgct caggttgaca gcaactttac ctaccacctt
     3601 gaaggcaatg aagagaagaa tcaatccgca gaatactacg ctcatggctg aaatagacat
     3661 accgataccg actgagtcat gttcttcgaa cttttccatc ttggcattac tgtcaagggt
     3721 tttgttgttc gtgctcgggg ttacgtattt gtctttgctt ccgcctttta cttcccagtc
     3781 tgctgctccg tcgcttatgc gtgcataaga ctggttggga cctaaagttc ctgctggtat
     3841 gacaacttga tcaagtagct ttctgcctga atcaaaaaga ccgacccaat tggctgtttc
     3901 ggggttcagt ttgaagctgg tatggaaggt accacgatta ggttcgccgt ctgcccaaaa
     3961 taacgcatgt tggcgtggct ttactaatgt aagtatgtca cctttcggga taaaataagt
     4021 tactgtatcg cccggctggc tgcttacttt caataaacaa gctgctaagt ctgcgctacc
     4081 gtatgatttg ttgaatattt caatccatgc actgtgcaag ccgtagtcat cctgaaagtt
     4141 attttgattg tctatcagga cttcattcag caatagctta ttgttcgact tttgctctcc
     4201 gcaggaagtc aatccaatca gcaacagcag agaaaggaat attccgattt tggttttgtt
     4261 cataatcgtt cttgttttaa tgtgaaaagt tggattacaa cggaatatta ccatgtttct
     4321 tcgccggatt agacagtttt ttagtctgca actgctgcaa agcacggatc acgcggaaac
     4381 gtgtgttacg gggttcgatg acatcatcga tgtaaccata cttagctgca ttataaggat
     4441 tggcaaacag ttttgtatat tctgcttctt tttcggcaag gaactgagcc ggattttcct
     4501 gttctttggc ttcacgcgcg tacaatactt ctactgcgcc ggcaccaccc attacagcga
     4561 tttcagctgt tggccaagca tagttcatgt caccacgaag ttgtttacaa ctcatcacga
     4621 tgtgagaacc accgtaagat ttacgcaatg tgattgttac tttaggtaca gtagcttcac
     4681 cgtaagcata cagcagtttg gcaccatgaa ggataacgcc attgtattcc tggcctgttc
     4741 ccggaaggaa tcccggtacg tctaccaacg acacgatagg gatattgaaa gcatcgcaga
     4801 aacgaacgaa acgtgcgcct ttgcgagatg cgttgctgtc gagtacaccg gcaaggaatt
     4861 taggctgatt ggctacaata cctacagact gaccgttgaa acgggcaaaa ccgataatga
     4921 tattcttggc atagtctttc tggatttcca ggaattcgcc gttgtccacg atagcgctga
     4981 taacctcgta catatcatac ggtttgttgg ggctgtcggg gataatatcg ttcagagaat
     5041 cttccagacg gtcgatcgga tctgtgcaat ccacgtatgg agcttcttcg aggttgtttt
     5101 gaggaatata gctcagaagt gtgcggatca atgccagacc ttcttcttct gttttggcag
     5161 tgaaatgagt aacacccgat ttggtagagt gaacgcttgc tccgccgagg ttttcctggc
     5221 ttacgtcttc accggttaca gttttcacta ctttcggacc tgtaaggaac atataagaag
     5281 taccttccat catcagtgtg aagtctgtca gcgccggaga ataaacagca ccgccggcac
     5341 aaggaccgaa gataccggaa atctgcggaa tgacacccga agcgaggata ttgcgctgga
     5401 agatttctgc gtaacctgcc aaagcgttaa taccttcctg gatacgtgca ccgcccgagt
     5461 cattgatacc gatacaagga gcacccatct tcattgcctg atccataatc ttacagatct
     5521 tcagtgacat tgtttccgac agtgaacctg cagtaacggt aaagtcctgt gcaaaaagat
     5581 atacgagacg accttcgata gtaccgcaac cggttactac accatcaccc ggatagtgct
     5641 ttttctccat gccgaagttc gtgcatctgt gctcaacgaa catgtccatt tcttcgaagc
     5701 taccctcgtc aagcagcata gccagacgct cgcgtgctgt gtatttccct ttttcgtgtt
     5761 gcttcgcaat tgctttttca ccgcctccga tacgtgctac ggcacggcgt tcaataagct
     5821 ctttaatttt ttcaagttga ttactcatga gttcttgttg tttttttaga gtttatgatt
     5881 agtgttcgca gagttctgtc agcacaccca gtgttgattt cgggtgaagg aaagcgatgt
     5941 tcagaccttc ggcacctttg cggggagcct tgtcaatcag acggatttct ttgctttctg
     6001 cttctgccaa agcattagct acgccatctt ctacggcaaa tgctacgtga tgaacacctg
     6061 cacctttgtt ttcaataaat ttagcaatgg tgctttcggg gcaagtcggc tccaacaatt
     6121 cgatttttgt ttcacctacc tttaaaaaag cggttcttac tttttgatct tctactgttt
     6181 cgatgttgta acatttcaga cccaatacgt tttcgtagta aggaagggct tcttcgatgc
     6241 tttttacagc aatgcccaga tgctcaatgt gtgaaatctt cataactata tttttttata
     6301 tggtttaatt atgtgcttat atggcataaa acagcacaaa gaaagacatt tcttgtctaa
     6361 taaagaaata tttctgcatt taattattgg ggaataaagc ataaaaaatg ctccggatgg
     6421 gtgacaaaga cgggttttgt aatcttgaga ttacatttag acataaaact tgaccagaag
     6481 attattcagc catggccagc tgatacggaa ccagcggcgg gtactgcttt gtttgcctcc
     6541 gaaacggagt acgaaatcac gataaccatg tttgcggaag ggaagtccta catccatgaa
     6601 ctccatgtga cggaatcccc gttcatgggc atcttcaagt gctttccata ctgccagtat
     6661 gccgggtgac tgcagtgcat aggtctttcg cattcctcct gaaaaccaga taaaagcatt
     6721 ttcgccggaa tagatgcaga cggagccgcc gataatcttt tccttgtatt ttacgatgaa
     6781 tatttttgcc tgttttcctc tgataagcat gctgttcatg tggcggaaaa agtcattggc
     6841 agggaaatat ctccgtattc gtgaagaata aactttgtgc agcatccgcg agaattcctt
     6901 aatctcttcc accgtatggg cttctactac tttggctccg tttttgagcc ctttccggat
     6961 ctgacggata cgtgacgggc tgaaacggtc ttccgctttc tgcgtactat gcagagagtt
     7021 acggacacgc agccagttga ccggaaaaaa gtcgttcttc cggaagaaac ggtaaccgaa
     7081 catggaatta tccagattgc ggaattcaat aagaatgcag gtgcgtgatg cttcttgtgt
     7141 gagatgctcc agcatttcac cgaaaatttc ttcctccttc tctttacttg ccggtagaga
     7201 agtgtccaga aattcacctg caccatatac cacacattgt ttgacaagag aggagggaag
     7261 ccactttttg gtcttgcgta tggcggcaag cagacgtgct acaggtctgc cttcttctgt
     7321 tgccactatc agtagcgggg tatatcccgg agtcgattca tagatctgaa acaactcctt
     7381 ggaatgaaaa gtattggttc ccggtaaatc aggaatgtct tttccgcgat aatatgttgt
     7441 tagtttaagt ggcatccaaa tacaaattta cactttttat tcttcattca acaataaaaa
     7501 agagaatttg ttggcttagc ctaaaatttg tctttttatc ctttgcatat atttgaggaa
     7561 aaaaaggctt ggaaaagcga atttttgtat tattgtcgtc ctttgtgagt acagaagtaa
     7621 aatggaaacg tctatgtaaa agattatgct aattgtattt tactaaacaa aggaaaatta
     7681 atattaactt taaattaaaa cgaatgagag agaatgcatt tgttgaagcg tggaagacac
     7741 agcatagacg cgtttccatg attttagggc tgactttatt gtgtgcccct tctgccatat
     7801 ctgtttatgc agaaaatggt gtgaatgata ttactgtgca agccgtcatg cagacaaaga
     7861 cagtgaaagg aactgtttta gatgaaaatg gagaaccgtt gatcggtgtt tctattgtgg
     7921 tgaaaggtac aagtacaggt acgataactg attttgacgg taagttctcc attaatcttc
     7981 cagccggaag taaagaactg gttgtttctt atatcggata taaagaacag gctattattg
     8041 tgagcggaaa tgccccgctg aatataaaga tggttccgga tacacaggct ttggatgagg
     8101 tagtggtcat cggttacggt acggtaaaga aacgtgattt gacaggtgcg gttgcttctg
     8161 tgaaatcaga ggatatcacc atgaatccgg gcgtgaatcc gatggatgcg ctgcaaggta
     8221 aaattgcagg tctggatatc actaattctt caggtcaggc aggttcgtca ccgacagttc
     8281 agttgcgtgg tacccgctct ttgcagttgg atgaggatgg taatatttct tccgatgcat
     8341 ttaagccgac ttatattatc gatggtatgc cgggtgatat tgctaccctg aatcccaatg
     8401 atattgaatc tatcgaagta ctgaaagatg catcttctac ggctatctac ggttcaagtg
     8461 gtgcgaatgg tgttattatc gtgactacga agggatctaa aagtggaaaa ccggtcatca
     8521 atttcaatgc ttatgccgga acgactatgg gtgcccgagt acctaaaatg cgtacgggtg
     8581 actcatacat taattatata aaagattctt ataagcctgt cggtactacc aatgaggagg
     8641 aaattttcgg tgaaagatac gatgccatca aaaacaacca atgggtaaac tggggagatg
     8701 aagtattaca ctcaggcttg aagcagaact atagtatttc cgttgccgga ggtactgaga
     8761 agacgaaagc ttatttctcg ttgaactata ctgatgagaa gagtatgtat gagaatgatg
     8821 actataaagt gtactctacc cgtgtccgta tagatcagga aatcaataaa tggattaatg
     8881 ccggtattaa tgttcaggca tctttctcca acaagaattc acgtaatgcc gttttagaaa
     8941 gagcattgtt tgctacccca ttgggtgttc cttataatga agatggctct atcacggaat
     9001 tcccgattcc aggttcatca tcagacccta atccgttagc agacgaacag gatggagtat
     9061 ataagaataa tactaaagca ggaagggctt atgttgacgc ttatctggaa tggaaaccgg
     9121 taaaaggatt gtctgtcaag tcacagcttg gaggcagtta ttctcaatct cgtgccggta
     9181 aatttatggg agaaggctct tataatgtgt tgaaaggcag tacggtggca tatggcgaag
     9241 ctaccaataa gacgggatat aattacaaat gggaaaacat agtaacttat cacaatacat
     9301 ttaataaagc tcatgacctg acaattacag gggttacttc ctggaattac aatcagagtg
     9361 aagaatatta tgtctatggt gaaaacccgg cgaccaatga tatgttgtgg tatgcattgc
     9421 agaatgctga taataagaaa ctgaacagca aatatctgat gtcgaagggg atgggcttta
     9481 tcggtcgtgt caactactca tacaaaggta aatacctgtt ctctgcttcc agtcgttatg
     9541 aagcggattc ccgtttgtcg aaagacaata gatggaattt attcccggca gtttctgtag
     9601 gctggagaat ctcggatgaa gcatttatgg ctggtacaaa aagctggttg gataacttga
     9661 aactgcgtgt aggctatggt gttgccggaa ctactgccgg tattgctgaa tacagttcta
     9721 tggcatcttt ggaaaatgtg acaacttctt tgggaggaat gactgttccg tcagccaagt
     9781 ttacggagta tatcactaac cgtaatctga catgggaaaa gactcatgac ttgaatattg
     9841 gtattgacgc cagcttcctc aataatcgta ttgatctgac ggtggatttg tatcggacaa
     9901 aaacaacgga tgtaattctt tcgcaggcat tgccgacatc tattatgggt aattacacag
     9961 gtagcactac ttataaaatg aacaagaatg ctgctgaaac agaaaatcgc ggtattgaac
    10021 ttgctcttaa tacccgtaat attgtgaaga aagattttac ttggagctca acagtgacat
    10081 ttaccgccaa caaagaaaaa attaaatctt tgatcgaagg gcaggatatg atgttcaatg
    10141 caaaaaaggg tgatatggtg ttcaaagtcg gcgaaggagt cggttctttc tatagatata
    10201 aagtgttggg tatctggcaa tatagcgaaa aggaaactgc tgctttgttc ggatgcgaac
    10261 cgggcgatat taagctggat ttacctagtg tgaagaagga cggaaatggt tattattata
    10321 tgaatcctga aggagagcgc gttgatatta cggcagaaaa tccttatggt gtacgtgcgg
    10381 attatgatcg tcaggtaata ggtcgtaata ctccggactg gacattgggc tttaagaata
    10441 atttcagata caaagatttt gatttgtctg tcttccttta tgcacgttgg gggcaaatga
    10501 tgaactatgg cagtgtgata ggtaaatatt cgcctaatcc ggattacaat attcctactt
    10561 attttactta ctatgacaag acgatcgaag cagatcagga tgtcttgttc tatgctatcg
    10621 ataaatccaa ggatagaagt gcttatgaag gatatgattc gatgtattat gtggatggat
    10681 cattctttaa acttaaaaac gtaacattgg gttatacgtt acccggtaaa cttacaaaac
    10741 gttttggtat cagtaatctg agagtttatg cgacaatgac caacctgttt acttattcgc
    10801 caaacaaata tgtgaagaat tacgatccgg aaatgaacgg aagcatcaac ttcccattgt
    10861 ctcgtgattg catatttggt cttaatttaa ctttctaaaa aatagcaata tgaaaaagat
    10921 atatagttta gttctacttg ttgccggtgt tttttcttgg ggctcttgca gtcttgatga
    10981 agtgaacccc aacaactcgg gtcagttctc cgatggttct tatacattgg aaacttataa
    11041 ggcattcacc aactcgtgct atacagcctt gatcaacaac atctatcaga gtagtgacta
    11101 tctggtttgt acggaagcgg gtactgatat ttgggaagaa cccaaatcgg gctccagcta
    11161 tcagcgttat catagttata acggtatgaa aaccgatgat agctattatt ataaagtgtg
    11221 gcaatattct tatctgtgta tcaacagctg taatattgtg attgacggag ctgagaatgt
    11281 gacaggggat gagaatgaaa tcaatgaatg tgtggcacag gccagatgtc tgcgtgctta
    11341 ctattatatg aatttggtgg agcagtttgg aaatgtcgat ttgcagttga aggctgccga
    11401 tagcgagaat atttcttttg atgctcaccg ttctaccgtt cccgaaattt atgctgccat
    11461 tatcgaagac ctgaagtttg ccgtagagaa tctgcccgta agtttcagtg attactatag
    11521 ccgcgttaca aagaaatcgg cgatgggatt attggcacgt gcatatatta atggtgccgg
    11581 ttatgatctg aaagataccg atggtgtcag ctttctggaa aaagcctatg atacggcgac
    11641 aaccatgatt aataataaag cgatttatga gtggtatatg catcctgctt ttgccgatgt
    11701 attcaacgaa aataataatc gtaacaatga agaagctctg ttcattgctg cgggtgccga
    11761 aagaaattcg gacgcttaca ccaatggtaa ctactcacaa agtgaaatgt tccgtcactt
    11821 cttaccttcg ttgggaacat atacggatct gggtttggta gacaagactt caaacttcgt
    11881 ttacggtcgt ccgaacagta atatcttcct gccatccaaa tatctgatgg actgttttgc
    11941 tgctgatatg aacgactctc gttttcgtta ttcatttatc tcagcttact cgtcttattc
    12001 tataccggca tggggggcga cttatgaata tggaggttca gcgtgtgcca aagaaatcac
    12061 aagcacactt gctactaaat ttggtattcc cgcatctaat ataggtaaga aagtttatcc
    12121 tcattttaac ttggaatcca atagtacagc cgatgctaat tactgccagc tggctatctg
    12181 gaatgcagat ggaacagcga agactactca ggataaaaca gatggtaata ttcttcatcc
    12241 tgctatgcct ttagatccgg cagaagctca tcaatatgcc gtttattgtt ctttgaagac
    12301 gctgacagaa gaggaaaaag ctcaatatcc ggggttggtt cttaatgttt tcgatcttta
    12361 cgatgagaat ggaacagcca gggctaccta tgacaagcct agtgctgcca gtgctttgtg
    12421 gttatctatt tatccggctc tttctaaatt caatatgccg ggtaataagt ttgtcggcag
    12481 agacgttcag agaaaaactg tggatgtgat gatcatgcgt atggcggaag tttacctgat
    12541 tgctgctgaa gcatcggtac gcttgaacaa gggagatgct gccaaatata ttaatgtact
    12601 ccgtacgcgt gccggtgccg gtacggtcag tgagtcgcaa gtggatctga attatatttt
    12661 cgatgaatat gcccgtgaac tttgtggcga atgtggccgc tggtatttgc tgaaacgtaa
    12721 tgctgctttt gagactcgtt tggctgctta taataagcgt gctgctgagc actttaagaa
    12781 agaattctat ttgcgtccta ttcctacgaa atatctggat gcgatcaata atccggcaga
    12841 attcggacaa aacgccggtt attaatcagt taattaataa tcaagcataa ttaataggag
    12901 ccgggcagga gatttctctt gtccggctct ttgtttccat acctgtatcc tgcgtaaaag
    12961 tttaaaaagg atttccggta tattttcatt gtttcctgat acagcttttt attattttct
    13021 ttatttttgt gtgtccaaac aaaatagcgc tatgatagaa gaaatgcttg cttataacag
    13081 agagttcgtt aagaacgagg gatataaaga atatataacg aataaatatc ccgataaaaa
    13141 gattgctatc ttatcctgta tggatacacg cctgacagct ttactcccgg ccgcactagg
    13201 cattaagaac ggagacgtta aaatgatcaa gaatgcagga ggtgtcattt cccatccttt
    13261 cggcagtgtg attcgcagtc tgcttgtcgc tatcttcgag ttaggtgtgg aggaaataat
    13321 ggtgattgcc cattctgatt gtggagcctg ccatatgcac agtgaagaaa tgcttgagaa
    13381 gatgaaggca cggggtatta atgccgatta tattcatatg atgagttttt gtggagtcga
    13441 ttttcattct tggctagatg gctttgaaga tacggagaag tcggtaaggg gaacggtcga
    13501 ttttatagtt catcatcctt tgattccgtc ggacgtgaaa gtgcacgggt ttatcataga
    13561 ctccactact ggagaactga cgcgaattgt ataggaaatc gccctttctg cctatcagga
    13621 actgcataaa acatggtgtc actatcgcaa caggatagtg tcactatcac tgtctcatgg
    13681 tgtcactatg tcattgggat accgacacta tcccaaatga aaaaaataag gcagcttttt
    13741 atcggctgcc tttatctttc tgcggttata tactttcttt gactcatgca ctcgtttgta
    13801 acaaacgggg tgtccgtgct ctttgatttc tgcctcacgg ctggctttac gattcgcttt
    13861 gatgtaatcg tcttgtgtaa ttcgtttttt cataatgaat atatttctca gtgcaaagat
    13921 acaatttcat ttcttattac gatcggtttg cgctatcttt gcatacataa atcaaatgaa
    13981 aacggaaata atatggaaaa tttcagtgaa ctgataaaga atcgccgcag tatgcgcaaa
    14041 tttacggatg aggagttaac acaggatgag gttgtggcac tgatgaaagc tgccttaatg
    14101 tctcccagtt ccaaacgtag taatagctgg cagtttgtgg tagtcgatga taaagaaaag
    14161 ttgaaagaac tgtctcactg caaagaacag gcttcttctt tcattgcaga cgctgctttg
    14221 gcgattgtcg tgatggcaga tccattggcg agcgatgtct ggattgaaga tgcttctatt
    14281 gcttccatca tgatacagtt gcaggcggaa gatttggggc tgggaagctg ttgggtacag
    14341 gttcgcgaac gtttcactgc aaccggaatg ccgtctgacg agtttgttca tggaattttg
    14401 gatattcctt tgcaactaca gattctttcc gtgattgcca tcggacataa gggaatggaa
    14461 cgtaagcctt tcaacgaaga acacctccag tgggagaaaa ttcatattaa taagttcgga
    14521 ggaaaataac gatgggagct gtcaaagcaa ataataataa agatacttat aaggctactg
    14581 ccgtcgcttt tattgtcatc ggaactcttt tcctgataaa taaactgctc ccctttgctt
    14641 ctataggttt gccttgggtg atgaataagg acaatttgtt gttgtatgcc tctatcagtt
    14701 ttcttatttt caaacgtgac aagtcggtcg gctttgtgct gttgggactg tggctggtaa
    14761 tgaatatcgg tctggtaatg tcattgctcg gttccttgtc cggttatctg ttgccattgg
    14821 cactgttgat catcggaatt attttatttt gggtttcaaa acgttaaaga aacaatgaaa
    14881 agaagtattg aagatacgcc cgttgtgttt ctcggtgccg gaaatctggc aactaatctg
    14941 gcgaaagcgc tttaccggaa aggattccgt atcatgcagg tgtacagccg aacggaagaa
    15001 tcggctcgta cgttagccaa tgaagtggaa gcggaatata tcactgattt aaaaggcgta
    15061 tcgaatgaag cgagattata tattatttca ttgaaagatg ccgctttcgt cgaactgttg
    15121 cctcagatca ctgatgggaa gcagcatgcg ctgctggtac atacggcagg tagcatcccg
    15181 atgaatattt gggaaggtca tgcggaacgc tacggagtat tttatccgat gcagacgttc
    15241 agcaaacaac gtgaagttga ttttcgggaa gtacctttct ttattgaagc aaaaagaccg
    15301 gaagatgccg agctgctgaa agcggttgcc ggtacgctct ctgataaggt gtacgaagcc
    15361 gattcggagc aacgcaggag tcttcatctg gcagctgtct ttacctgtaa ctttaccaac
    15421 catatgtatg ctcttgccgc cgaattgctg gaaaaatatc atttgccatt tgatgttatg
    15481 cttcccctga ttgacgaaac ggcacgcaaa gtgcatgaac ttgctcctcg tgatgcgcag
    15541 accggaccgg ctgtacgcta tgacgagaat gtgatgaata agcatctttc tatgctggca
    15601 gacagtcagg cattacagga aatttataaa ttaatgagta aaagtatcca tgagcaccat
    15661 caattatgat ctatcccgca tcaaagcact ggcttttgat gttgacggag tattgagttc
    15721 gacaacagtc ccgttgcatc cttccggaga accgatgcgt acggtgaata ttaaagacgg
    15781 ttatgccatt cagctggcag taaagaaagg actccatatt gctatcatta ccggtggacg
    15841 gacagaagcg gtacgtatcc ggtttgcagc attgggtgtg aaggatctgt atatggggtc
    15901 tgcagtgaaa attcatgatt accgtgattt ccgcgataaa tacggtctgt ctgatgacga
    15961 aattctgtat atgggcgatg atgtgcctga tatagaagtg atgcgtgagt gtgggttgcc
    16021 ttgttgtccc aaagatgctg ttccggaagt taagtcggtc gcgaagtata tatcttatgc
    16081 cgatggcggt cgtggctgtg gacgtgatgt ggtg
//
