LOCUS       gnlProkkaAKIJKAMB_78   10568 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AKIJKAMB_78.
ACCESSION   gnlProkkaAKIJKAMB_78
VERSION     gnlProkkaAKIJKAMB_78
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 16:02:52
            Original ID  :: gnl|Prokka|AKIJKAMB_78
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10568
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10568
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1254:5568]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1255..5568
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10568
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10568
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             43..1191
                     /locus_tag="ctg78_1"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1255..1974
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.9e-17, bitscore:
                     52.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             1995..3296
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2e-13, bitscore:
                     40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 8.4e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3313..4437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.1e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.4e-21, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4447..5568
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg78_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_5"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4537..5544
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg78_5_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg78_5_Aminotran_5.1"
                     /locus_tag="ctg78_5"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5565..6038
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6035..7480
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_7"
                     /sec_met_domain="Polysacc_synt (E-value: 8.4e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7480..8202
                     /locus_tag="ctg78_8"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8216..9229
                     /locus_tag="ctg78_9"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9234..10193
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_10"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1e-42, bitscore:
                     135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 ttctattgct aatcttataa agaaataata gaatttactt ttatgtcaga acaacgacag
       61 gataaaaact tgctctctga accacacaag acagaaagtg atgagataga aattgatttg
      121 gtcgatatct ttcgcaagat tattgctatt cgtaaaaaat tatacaaagc cgttggaatt
      181 ggttttatta ttggaataat tgtagcggta agtatcccta aacagtatac agtaaaggtt
      241 accctttctc ctgaaatggg taatgcgaag gggagtaatg gtttagccgg acttgctgcc
      301 tcgtttttag gagatggggc tctaataggg gaaagcacag atgccttgaa cgcttctctt
      361 tcagcagata ttgtttcttc aactcctttt ttattggaac ttttagaaat ggaagtctcc
      421 gtttctaaaa aggatgataa aatgactttg gggtcttatc tcgatgaaga gtcatctcct
      481 tggtgggatt atcttatagg ttttccgggc atagtaatag gaggagttaa atcattattc
      541 ggagaagata cggttcctgc cagtggaggg cggcaaggaa ctatcgaatt gacgaaagaa
      601 gtaaatgaga agattaattt tcttaaaaag aagattagtg catccattga taagaaaacc
      661 gccataacga gcattacggt caccttacaa aatccgcaga tcactgcggt tatagcagat
      721 tctgtcgttc ataaattaca ggaatatatt attgggtatc gaacttcaaa agtaaaagaa
      781 gactgtgcgt atttggaacg gttgtttaaa gaacgtcagc aggaatatta tgctgctcaa
      841 agaaaatatg cggattatgt agacgcccat gataatgtgg ttcttcaaag tgtacgtgct
      901 gagcaggagc gtttacagaa cgacatgagt ttggcttatc agatatatag tcaggttgct
      961 aatcagttgc aggtatccag agccaaagta caggaggaaa agccagtctt tgcagtagtt
     1021 gagcctgccg ttgtaccttt gaaaccttca ggtatgggac tcaaaattta tattttatta
     1081 tttgtgttcc tgtccgtatc tggtactctc gtgtgggtgc tttttggcaa aagtctgctg
     1141 gctagcttga gaaaagaact gaaaaataag gagatagaac aggataaatg atgctaaaac
     1201 gtcgtttaca acattcttac atcaattaaa ttcacttact atattattaa acgaatgata
     1261 cgtacagcta tgataatggc tgcgggcatg ggaacccgtt ttggccaata tacagaattg
     1321 atacctaaag ggttcgtcaa agtgggaggt attccaatga tagttcgttc tattgatact
     1381 ttgttatcat gtggcattga gcgaattgta atcggtacag gatataaaca agaagtttat
     1441 gaagaattga agacagacta tcctatgctt gaaacctgtt ttagtcctcg ttatgctgaa
     1501 acaaatagta tgtatacttt atataatacg cgggagattc tgggcaatga tgatttttta
     1561 ttgttagagt cagatttgat ttttgagaaa caagcaataa tgagcttatt ggagtgtcct
     1621 gcggcagatg caatgctaat aactccagtg acaaagtttc aagatcagta ttatgtggaa
     1681 catgatgata attttcgcct ttcttcatgt tctgtcaata agaataaact aaacgctaaa
     1741 ggcgaattgg tcggcatcca taaactatcc ggttcctttt acaaaataat gtgtgctgat
     1801 tatgcgagta ttgttgatga acaacccaat ttgggatatg agtatgaatt actacgaata
     1861 tcttgttctc aatctcctgt ttatgtgcat aaagtagaag ggctgaaatg gtatgaaatc
     1921 gatgacatat cagatttgga atatgcagag aaatatattg ttccgtattg ttaattaaaa
     1981 taatatatca aattatgagt aagacagttt atattgggat gactgcggat attatgcatc
     2041 caggacttat ccgcattatt aatgaggcta ctaaatacgg tgatgttata attggtcttc
     2101 ttacagataa agctattgcg gagcataaac gccttcctta tctgacctat gaacaacgaa
     2161 aagaggtagt tcagaatatt aaaggcgtat gtaaagttgt tcctcaagaa gaatggagct
     2221 atgttgagaa tctcaaacgc attaaacctg actatataat tcatggtgac gactggaaaa
     2281 ccgggccttt acgtgaagaa cgtgtgcgcg tatttgaagt gatgaatgaa cagggaggaa
     2341 aggttatcga aattccatat actttgggaa ttaattcatc ttctttggat aaagatatta
     2401 aggctatagg tacaacccct gatgtacgtt taaaatcact tcgtcgtttg ataaatgcca
     2461 aacccgtagt tcgtattttg gaagctcatg atggactatg tggcttgata attgaaaatc
     2521 aggaaatatt aaaaggggat aagagggaag tatttgacgg aatgtggtct agtagcctta
     2581 cggattcaac cagtaaaggt aaacctgata ttgaggcggt tgatttaact acccgattgc
     2641 aagatttgaa taatattctg gagtgtacta ctaaacctat tatttttgat ggagatacag
     2701 gtggtaaaat tgaacatttc gtatttacag tacgcacttt agaacgtcat ggaatttcag
     2761 ctataataat tgaagataaa gttggattaa aaaagaattc attgtttggt acagatgtta
     2821 ttcaaactca agatacaatc gaaggtttct gtaataagat caaagcagga aaggcatctc
     2881 agattactga tgattttatg attatcgctc gtattgagag ccttatagcg ggaaagccgg
     2941 taagtgatgc tttagagaga gcttttgcat atgtccaagc gggagcggac ggtattatga
     3001 tacatagcaa aaataagtcg ggtgaagata taaaagaatt ttgtttggcg tttcgaaaac
     3061 agtatgctca tgtacctatc gtggttgtgc ctactacata tgatcatatt tatgagtctg
     3121 aattgtgtga ttggggtgtg aatataatta tttatgctaa tcatatgctt cgtgccgctt
     3181 atcctgctat gatgaatgtc gcaaagacaa tattagagaa tgaacgtgct ttagaggtgc
     3241 gcgaactgtg tatgcccata aaagaaatat tggaactgat tccaggtact aaataaaaag
     3301 aggaatatca ttatgttaag cgtagaaaaa gtttatgaaa cgtttctgag tcatgacgtt
     3361 gattttttta caggagttcc agactcatta ctaaaaaata tttgtgccta tatcacagac
     3421 catacttcac gtgagaaaca tatcatagct gctaatgaag gtgcggctgt aggaattgct
     3481 tcaggttatt atatggcatc aggtaaggtt cctgtggttt atatgcaaaa ttccggcttg
     3541 ggtaatactg ttaatcctct gctgtctctt gcagatgaac aagtatacag ttttccaatg
     3601 cttttgatga ttggctggcg tggtgaaccg ggaacaaaag atgaacctca gcataaaaaa
     3661 cagggtgagg taactttaga tttgttgaaa gcaatgcgga ttccttatat aattcttgat
     3721 tcaaatgaga atgatgcatt tattcagctc catgatatca tacaatcagc aaaaactaag
     3781 aatattcctc atgcaataat tattcggaaa gatgtttttg gcaaatataa acttcaaaaa
     3841 gagtttggat gtaattatcc tttatctcgt gaggatgctt tgcaaatagt tgtggattat
     3901 ctgcctgaaa attcagtggt cgtttctact actggcaagc tttctcgtga gttatttgaa
     3961 tatcgagaaa tgaaagagca aggtcatgaa catgattttc tcacggtagg ctctatggga
     4021 catagttcat caatctcttt gggtattgct atagcaaagc aagatagacc tgtttattgc
     4081 ttggatggtg atggagcatt tattatgcat ttaggggcaa ttagtaacat tggcgattta
     4141 tctcctaaaa actattatca tattttgttt aacaatggtg ctcacgagtc tgtaggagga
     4201 cagcctactt taggatttag tttagatatt ccggctattg tccgggggag cggatataag
     4261 catacttata ctgtttgtac aaaagttgaa attgaagaag caatgaagca gcttccaaag
     4321 ttatgtggtc ctgttttgtt ggaaataaag gttaaaatag attctcggga gaatttggga
     4381 cgtcccacga ctactcctat agagaataag gagcatttta tggatttttt aaaataaata
     4441 tattcgatga aaatagaaag aaaaatatta ttaaatcctg ggcctgccac tactactgac
     4501 agtgtaaaaa tggcacaagt tgttccggat atttgtcctc gcgagaaaga attcgcaggt
     4561 atgatgaaac aacttcggga cgatttggtc agagttgctc atgggaattt ggaaaaacat
     4621 accgctgtat tattttgtgg ctcaggaacc atcaatattg atatatgtct aaattctctt
     4681 cttcctgaag acaaaagggt gcttatagtg aataatgggg catatagtac ccgtgctgta
     4741 gaagtgtgtc aatattatgg tttgcctcat attaatttgg aattttccgt ttatgaacgt
     4801 cctgatttat cggtggtgga aaatgtgttg caagaaaatc ctgatatagc tatggtttat
     4861 actactcatc acgagacggg tacaggaatt ctgaacccta ttcgcgagat gggcgctata
     4921 gctcataaat atcaggctaa atttgtcgtc gatactactt cttctttggg catgattcct
     4981 tttgatatag agaaagataa tgtggatttt tgtatggcat ctgctcaaaa aggacttcaa
     5041 gcgatgacag gtctttcttt tattataggc aatgaggaac agattaagtt ttcaaaaaaa
     5101 tatcccaagc gttcttacta ttgtaatctt tatttgcagt atgagaattt tgagagaaca
     5161 ggtgaaatgc attttactcc accggtacaa actatttacg ccactcgtca ggcattaaat
     5221 gaatattttg aagtgggcga agaagctaag tttgcccgtc acaaaagagt ttttgaggct
     5281 attcattcag gtataaatga aattggtctt aaaagtgtaa taaagcgtga atggcagtca
     5341 ggactggttg tctcagttca atacccagaa gatcccaact gggattttga gaaaatacat
     5401 gattattgtt atgagcgtgg atttacgatt tatccaggta agatatcaac tgaggatact
     5461 tttagaatct gtgctttagg agagatagaa gtagatgata ttgagaactt ctttaaagta
     5521 ctaaaagctg cattaaatca ttataacgtc acattaccga tgtcatgatt gcagaaatat
     5581 tattgaagat tcgtcatttt tatttttccc ttcgtggtat acacttccat ccggaaagtg
     5641 ttatttctgg agtgcctatt cgtagctttc gcttagtagg caaatatagc aatatctact
     5701 taggtaaaaa tgctgaaata cgttcaggct gttatctgat tgctcgtgat aaaatcatta
     5761 ttggagaaaa ctcaacactc gcctatggaa cgactatatt gacaactgct gatcctaatg
     5821 gaccgtataa tgcattagca gttctttatc cttataaaaa ggcaccggta gttataggag
     5881 ataatgtttg gattggggct aatgttacca tccttcctgg agtaactatt ggtgattacg
     5941 ttgtagtagc agctggagct gttgtaacaa aagatgtacc ttcaggagta ttggtagctg
     6001 gtgtaccagc tattgtgaaa aaacgtttta ataaatgaaa gaaaaaactt ctttaaagaa
     6061 caaagccata tgtggaatct tttggagtgc agttgaacga tttttatcac aggggataca
     6121 gtttgtagtt acagtcatta tggcgcgttt tctattgcca tctgattatg gaatggtagg
     6181 aatgttagca atagttcttc aattatctca aacgttaatg gatagtggtt ttactaatgc
     6241 ccttattcgt tataaggaac gtactgaaat tgattattca acagttttct tttttaatat
     6301 attagcatca ttagttattt attttctaat tttttttcta gctccttata tatcgtggtt
     6361 ttataaaata ggtcaattag ttgagattac tagaatttta tctattgtta ttgttttaaa
     6421 ttcctttgcg attattccta aaactaaatt aataatagct gtagatttta aaactcaatc
     6481 aaaagtctca tttattgcag ctttggtttc aggtattatt ggcatttggg ctgcatattt
     6541 agattttgga gtttgggctt tagttggaca aactttagta aacggattgt tgattgtagt
     6601 tttgtatgca tatttttgta gatggaaacc attgtggata ttttcattga aatcgtttcg
     6661 tttattattt gcttttgggt caaaattagt attagctaat attcttaata ctttatataa
     6721 aaatctgtat gctatagtta taggaaagaa gttttcgtcg gttgatttag gattttatac
     6781 tcgtgcggaa caatttgctc agtttccttc atataatttg agtgcaataa tttctagagt
     6841 gacatacccc atattgagcc ttgtgcaaaa tgataatgat agattatctg ctttatatag
     6901 gaaatatgtc cgtttatctt ctgcttttat ctttccattg atgattttgt taattgtcat
     6961 agctcagcca ctggtattat tgcttttgac agaaaaatgg ataggagtag ttgtattgct
     7021 tcaaatattg tgtttagatt ggatgtttga tcatttgagt agtataaatt tgaatttact
     7081 atatgtaaag ggacgttcag acttggcttt acgtttagaa gttataaaaa aagtgttagc
     7141 gacggggatc cttcttctat ctattccttg ggggattgta ggtatgtgtt gggggcgtgt
     7201 tatgtattca ttgattgctg tgtatttgaa tacttattat acagaatcat tgattaaatt
     7261 aagtcttatt agacagatga gagatatact accaagcttt tttttagcat taataatggg
     7321 aggaggtact tggtatatga ttttattgtt agagggtgaa attgttcaaa ttgtagtagg
     7381 aagtgttatt gctttattgc tatatggaac gttgttgtat tgcttttctc gatccttgtt
     7441 tgatgaaata tgggcggtta tattaaaaat aaaaaggtaa tggataaact gagtttgatt
     7501 attagtaaaa tacgacggaa tcattggtat agaacctata tgcgtcctat atatttattt
     7561 gtttatggca atagaaaatt gaagaataga aatagaatat ttttgcagta ttcacaagag
     7621 ctgctaacta actttcatca agcaatgaat gaagtgggaa ttccttattg gttagaattt
     7681 ggaactcttt taggtgctgt tagagaacac agttttataa gtcatgattt tgatcttgat
     7741 gtgggccttt ttaaggaaga ttattcagat ataataagag aggtcttaaa aaaatatggt
     7801 ttcaaaagaa taaggtgtat aaccgccctt gattttattg atgcttatga ggaaacttat
     7861 ctttataaag gtgtgacaat tgatcttttc cttttttcaa gagagaaaaa ttgtgatggg
     7921 gtctattgtt atgattttgt tccagtatat tcagatataa agagaactaa aaaaggtgat
     7981 aatgcaatcc ggagaattca ttttcctaga attgatttga ttgaatattc atttattgga
     8041 attaatactt ttgttcctga aaattatgag gaacatcttt gtatgcatta tggtaaagac
     8101 tatatgattc caaatcctca ttggaaagat tcagatgcgc aacatactga tatcttttat
     8161 ggtagagaga ttagaattga attgtttgat aaaagtaaat aatagtagat aatacatgtt
     8221 ctatctattt tttttactaa ttgtgctatt tttgttatat atacaaagta ggaaaagaca
     8281 atattctact gtagcgggaa tttgtgttcc tattattata atttttgttg taatttgtcg
     8341 ttatagagtg gggtatgact atttaacgta ttatacatta attgaaaatg aagaagaggc
     8401 acagatttta tacttatttt ctcctttaag cattgtttgg gcagagattg ctttatattt
     8461 tgaatctcca cagatgttat ttgttctttt tgggcttcca acatttgctc ttctaatatt
     8521 tactttaaaa aaatattcaa aagattatgc gttatcagta actattttaa tttgtttctt
     8581 cttttttaca tcactcagta ttattcgaca agctttggct ttggctattt gtttttatgg
     8641 ttatcgtttt atagtaaaac gttcactaat taaatatata ttatgtatat tgattgcagc
     8701 tttattccat ccttctgcag gagtagcgat tattatatat tggttgccat ttctaaagtt
     8761 tagattagtt gtattattat ctataatatc aatagtagcc aaacctttat ttttttatat
     8821 gctaaatata ttaggggtgt atacctctta tcttgatggc aagatggata ttgaaggtgg
     8881 gaaatatact caattaatat actttttgtt gtttattatt tgttttgttt tgggaagtaa
     8941 aaacatagat aaaaacaagt gtaatttatt taatgtttta ttgttaagtt ttgttttcgt
     9001 atctttttta ggagctcatt taggcgggag aatagcgttt tattttaata tatattattg
     9061 tttgttgatt cctaaagtgg ttaaaggatt ggatggacaa ctaagagagc aagtgaagct
     9121 tctttcttat tttctatgta tttcttattt cttattgtac ctattcgttc cattcataaa
     9181 aggtgtaccc tcatattata tcccatataa gtttatattt ttcaaatagt aaaatgttga
     9241 tatctataat tgtcccttgt tataattctg aaagatattt gtctgattgt ttattgtcta
     9301 tattgaatca aacctatgtt aattgggagg tgatttgtat agatgatgga agtcaagata
     9361 atacattatc tattttaaat cattacgcta cattggatga gcgttttaaa attatttctc
     9421 agtctaatgc aggagtgtct gtcgcaagaa ataaggctct atcccagtgt caaggagagt
     9481 atatttgctt tgttgatagt gatgacctga tagaacctaa ttttttgata acacttttac
     9541 agcttataag tcatcaggct gatttggcaa tctgtggttt tactcgttct atggttttct
     9601 gtatggatga tgctcaagga tatatagaaa tgagtggtaa acgttgtata gaaagaatta
     9661 ttctagataa aagtttcaat cctcagattt gttgtatgtt atttcgacat aatattataa
     9721 aagagaaaca attagaattt gtgatagggt gtactcgtgg tgaagatcgt gaatttatat
     9781 tgaaatattt agtttattct aataaggttt gttatacaaa caatcttctt tatcactatc
     9841 gtgtaaatga tcagtcagcc atggcaatct tttctattaa aagtttgaca agtatagaag
     9901 cttcacaacg cacggtcaac tactataaaa aagtgaatta ttctgttaga gggcttgaat
     9961 ttgaattttc acgtacattg tggaaattca tgattttagc tattttgtct gggcaaaatg
    10021 atttatatca aatcattcga gaaaagtatg atctaaaaag acaaatggaa catctttatt
    10081 ctcatccagg actatccgaa aaacttacag cgagattgtt tgtttggaat gaggcacttt
    10141 ttaaatgggt attttctatt attagatatc tatataaaaa aagatggaga tgaataaacg
    10201 aaatagatta tctgaacaag aaataaaaaa agtagaactt gacgctttat tgtatattcg
    10261 gaaaatttgt cagcaatatc atcttcgcta ttatttagct tggggtactt tgttgggagc
    10321 cgttaggcat aaaggattta ttccttggga tgatgatatt gatataatga tgccacgttc
    10381 agattatgag cgattattgg agttagttcc ttccttgaga catagttatt ataaaatctt
    10441 aagtaatcca aagaatgagg attattatta tactcatgca aaaatgatag atactcgtac
    10501 tttgtgtgtg gaaaatgatt tgcaaactat tcaaaatatg gggatttggg ttgatatttt
    10561 ccccttag
//
