LOCUS       c00044_gnlPro..        15094 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JDNGEEBH_44.
ACCESSION   c00044_gnlPro..
VERSION     c00044_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 21:01:02
            Original ID  :: gnl|Prokka|JDNGEEBH_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15094
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15094
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1654:5094]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1655..5094
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15094
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15094
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(3..98)
                     /locus_tag="ctg44_1"
                     /transl_table=11
                     /translation="MKKEKSLTRRKGEPYPLEIRLAAIGEYRLGVS"
     CDS             complement(442..1395)
                     /locus_tag="ctg44_2"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPASGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             1655..2329
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_3"
                     /sec_met_domain="SucD_FumR (E-value: 1.8e-66, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             2368..4311
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.5e-59, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 2.9e-37,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             4339..5094
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_5"
                     /sec_met_domain="Fer2_3 (E-value: 1.8e-25, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 5.5e-11, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.8e-05, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             5285..5443
                     /locus_tag="ctg44_6"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(5416..6447)
                     /locus_tag="ctg44_7"
                     /transl_table=11
                     /translation="MKIGTIDLGERPVFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREVRHYLDTGETLPAESFSWYLNILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     IDC"
     CDS             6828..8087
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_8"
                     /sec_met_domain="Peptidase_U32 (E-value: 2.5e-68, bitscore:
                     223.6, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNEKDFEIMAPVGSYESLMAAIQGGADSIYFGIEGLNMRSRSSNN
                     FTTDDLRKIVALCREHGIKSYLTVNTVIYGEDLPLMREIIDAAKEAEVSAIIAADVAAM
                     NYANSIGQEVHLSTQLNISNAEALKFYARFADVVVLARELNLKQVHEIYRQIVDQQITG
                     PKGELIRIEMFAHGALCMAVSGKCYLSLHEMNASANRGACMQICRRAYSVKDKDSNIEL
                     DIENQYIMSPKDLKTIHFMNKMMDAGVRVFKIEGRARGPEYVRLVTECYKEAVRAYCNG
                     TFDEKKVAAWDERLRSVFNRGFWDGYYLGQRLGEWSSKYGSGATKKKVYVAKGIKYFDK
                     IGVAEFEMESGNLKVGDEILITGPTTGAVMQTIEEIRVDLKPVDETVKGERFSLKVNEK
                     IRPSDRLYKMEKVQLEKVFE"
     CDS             8087..8494
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_9"
                     /sec_met_domain="HBT (E-value: 3.6e-08, bitscore: 27.7,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 5.6e-09, bitscore: 30.5,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYIFKLTDKVRDYECDLQGVVNNSNYQHYMEHTRHEFLESLGE
                     NFGKMHEKGVDGFVSRVEIQYKTSLKSGDSYISCLNVYKKGVKLVFEQDIYRASDNALA
                     TKGIVESVIVENGKLTRGEYFDEMLKRIEHT"
     CDS             8491..9606
                     /locus_tag="ctg44_10"
                     /transl_table=11
                     /translation="MTDKRIYQIGLTMINGVGDILARHLLQALGEAEAVFTEKQQLLGR
                     IPGIGSNIAAEIKRPEILQRAEKELAFIEKNNISCYYLTDTDYPVRLRECPDAPILFYF
                     KGNTNLDATRIISIVGTRNATEYGRELTESLIKDLAKVIPDLLVVSGLAYGIDICAHRN
                     ALYNRLPTVAVLAHGLDRIYPSCHRNTAVEMLESGGLLTDFPSGTEPDRPNFLRRNRIV
                     AGISDCTIVVESAEKGGSLVTADIAFSYGRDVYSFPGRIGDSHSKGCNNLIRQNKAGLI
                     TSADDLLSALCWDIQAGATSVQTELFFAEAETFTSEQNPVLAIMRTRNEIHINELASVL
                     EIPVHQLSMLLFELEINGKVKALPGNLYKLS"
     CDS             complement(9857..10747)
                     /locus_tag="ctg44_11"
                     /transl_table=11
                     /translation="MLSFILVLLLGGFMPAGNLLASDKEQNPHYITVKNSRDLQAYFRY
                     APDRPIVISGHRGGMLDGYPENCIESFEKTLSYMESFFEIDPRLTKDGIIVLMHDETID
                     RTTTGKGKVSDYTYAELQQFNLVDRNGNVTAFKIPTLKECLEWSKGKTILNLDIKDVPL
                     EVMADFIETEKPVNVMYTVHNASQARYYLDRKPDAMFSCWCKNREEFDNYEKAGIPWKQ
                     VMAYVGPKMKPEQQPLYDALHRNGVMCMISVAPTHDRAKTETEKTAGYRSEISTRPDVI
                     ETDYPYLFQGLDLTK"
     CDS             11355..11717
                     /locus_tag="ctg44_12"
                     /transl_table=11
                     /translation="MERLTRQEEDVMRWIWQIEPCFIKDILAKYEEPKPPYTTLASIVK
                     NLERKKYVKAKRYGNTYEYRPLIPQEEYKRTFMGSVVNNYFENSYKEMVSFFAKEQKIS
                     TDELKEIIDMIEKGRE"
     CDS             11738..13474
                     /locus_tag="ctg44_13"
                     /transl_table=11
                     /translation="MTPEFAYFLKVNVAFILLYAFYRLFFYKDTFFKLRRTILLAFFGV
                     SLLYPLMNIQDWIREQGPIVEVIQMYSAILPETTITPGNVPQTNWHDLLLPGISYLYWS
                     GVIALSFRFLVQLSSILLLARRSEVTLIRNVRVHLLNKPAGPFSFFRLVFLHPDSHSEK
                     EIDEILVHECTHVSQWHSIDVIICELVCIICWVNPFVWLLKREVRHNLEYLADDTVLES
                     GYDSRSYQYHLLGLAHTNRSVTSLSNNFNMLHLKNRISMMNKKRSRSIGRTKYLIFIPV
                     VGALLILSNVDALARITDELTESTFADVLLPEAILPFPFVGDASPAEKREEYVLSEEGI
                     EAARRARNPVFTVVEVMPEFPGGQGALLKFLATNVRYPESAVKNGIEGRVSCSFVVGKD
                     GAISEAEVIRGVSPELNEEALRVINSMPVWSPGKQRGKVVNVKYTVPVTFRLSGGKKKT
                     SSRIVQRQIKEVDTSGRVFTVVQQMPEFPSGQASLLKYLATRIKYPAIAQENGIQGRVS
                     CSFVVDTDGSLKNIEVIRGIDPSLDREAVRVIREMPKWNPGVQNNMAVAVKYTVPVTFR
                     LQ"
     CDS             13508..15061
                     /locus_tag="ctg44_14"
                     /transl_table=11
                     /translation="MKCKFSLLLFLCVLSLWGQAQSLNLQELVNKKQFQEVVARADSLT
                     PADSADYATMSAIGQAYEGLLRYKEAYQCFSHCLKMDTNNVDALNAVARNAINFGRIAE
                     AKQCYRKVLGTDSMNFYANYQLARLYYQLGDYGRATEHYHILASIEGENPSILTGLADC
                     HIKRGTGPNTMIALSLYARALELNPENVRVASSLINTLLRMGDGQGALQVCDTALFYNP
                     DNSQIRQSKGMALYMTKDYKQADSVYTGLLADGDSSFLNLKYAGAARYMSGHALDGVEL
                     LEKAYEIDSTDVETVMLYGASLGKTYDRKRAYELFDLAETNMQPKKFLVNMLTTFRGDA
                     LERDGRWPEAEKLYYAAWKEDPTQLHFLYKISTQYWDVDPGLFQQEEKLQKTIFSRYTY
                     LTAYMKTDKSQKYLYNYRPFLEAVCEDAFFRNADEVTMLAPDGKKTKLAVADLRALVAQ
                     LPQMPEDERLRREKMQEHIKKAREKEKELRKSGAKLDTLALSKEEKEKARKMLKDADLE
                     "
ORIGIN
        1 cggcttactc ctaagcgata ttcacctata gctgctaggc gaatctccaa aggataaggt
       61 tcacccttgc gacgagtcaa tgacttctct tttttcatct ttgttgactt ttatgaagtc
      121 aacctatttc aggacgagac aatcgctcat ctatctgttt taaatgaata aactccaagc
      181 attttaaggt aaaagtaggg agacaatttt atcaacaccc ccatgtatcc gcccccgaca
      241 cccggatctt acgctcttat agatccgggt gtcgggggcg gatacatggg ggtgttgggt
      301 aagttttatt acgtgttttt cattgatttg tagctgtatt tacataaaag agccttgtct
      361 ttgatgatat aggagaacaa gccctttttc cttttcttgt ttaccttgcc ctgcaaattg
      421 tcagtttgtt ttagtagaaa ttcaatcacg ttcgaaatcg gacagcactt ctgccgtagt
      481 agcgttgatg ttcttgtcca atacataaat gcggtaagac aggctcagtt ctttaccggg
      541 ttccaaggtg aatgccttct gcttggtcgg tgagaaattc cacatgacgt caccggcagg
      601 cttgttgaca gttttgtccc atacgcgtaa aggctcagga tagttcaggt tggaagggga
      661 ggcaacgatt aggatacagg ccttttcgtt tccggctttc ccttggtagt agcaccaacg
      721 ggctctcgaa ccgtcagctt cgtcgcggga aaggccttcc gaggtgagca tttcggctgt
      781 ctgatcgttc cagtcttcgc gcgtacggat gcatatgccg ccataacggt aagcttccat
      841 ggtgatcggg ctggggctgg cgaggcggat agtggtatga tagtcgatgt aataacctgg
      901 taaggatgtt gtcccgatgt tgatctccag gcgttcgttc attgctactt tttctgcggg
      961 agaatcgggg tagaccacat ggtccagtgt cgcaacaaaa ccgttgtcgg atacgtgttc
     1021 gaagttgcgg aagcgaactg ttccttgttt tttgtggaga ttccagaagt cgatctcgtt
     1081 tccttcgaac gtggttttcg tccaggcata ccacaaaccg aaatgatggt aatggtcggc
     1141 gggagaacaa ttggtcatca cttcgcctcc caatgtcttc aaaggatgga tgaaaccgct
     1201 gcgtttatag accgagtcaa cgccagaggc tgggtaaact gtggtatagt tgtaagagaa
     1261 caacagttta tctcctatct tatagtctaa ggttttcccc gtgtcgacga cggaacagga
     1321 tgtttcggaa ggctgacaag agcctaagaa cagagaaatc aaaaaaacac caatagaaaa
     1381 aatagcagtt ttcataatat gacaattaaa taataatcag ttatccggca agaccttgcc
     1441 tgtatcggct acaaaaaaac gaaatttttt cgtttcgcac aatccgtttg tgatatctga
     1501 tgcaaataaa accagccagc aagcagcgtt ctaattgatg aaatatttct ttaatcgttt
     1561 gcgtgatatg gggatttagc atacctttgc acgataataa ccatagattg gaggaaattt
     1621 ctaaatacaa ttaaataact taaattatta tcttatgtgg ttacttaatt cttctatcgg
     1681 gaagaagctg ataatgagta tatcaggtct ttttctcatt ctgttcttgg tgttccactt
     1741 atgtatgaac attgcggcag tattttctgg tgaagcgtat aacgtgattt gcggtttgct
     1801 gggttctaac tggtatgctt tgctcggtac attggtgttg gctgcaggtg tagtcgtgca
     1861 cttcgtgtat gctattatct tgactctgca gaatcgtaag gctcgcggta acgaccgtta
     1921 tgccatcaac gctcgtccga aaggtgttga atgggcttct cagaacatgt ttgttttggg
     1981 tgtgatcgtt atcctgttca tggttctgca ctttactcag ttctggtaca acatgatgtt
     2041 tgccgaactg gcaggtattc atggtgacat tcatccgcag gatggtgcag cgtttatcaa
     2101 tttctacttc cagggcaatg tcgtgaatac ggtgttgtat ctgatctggt tcgttgctct
     2161 gtggtttcac ctgactcacg gtttctggtc tgcgattcac acaattggct ggaacaatac
     2221 cgtttggtta agccgttggg aatgtatctc taaatgggtt gccactatta tttgtggctt
     2281 attcgctgtt atcacagtta tcttctacct gaacggtgta ggtgcttaat ttcggatatt
     2341 attttttcaa tttgaaaata aaacattatg actcaaatag attctaaaat tcctcaaggc
     2401 ccgttggctg agaagtggac aaattataaa aatcaccaga aattggtgaa tcccgcaaac
     2461 aaacgtcgtt tggacataat tgtagtaggt actggtctgg cgggtgcttc tgctgctgcc
     2521 tctctggctg aaatgggatt caatgtattg aatttctgta ttcaggactc tccccgtcgt
     2581 gcacactcta tcgctgcaca gggcggtatc aatgcggcaa agaattatca gaatgatggt
     2641 gactcggttt atcgtctgtt ctacgataca atcaaaggtg gtgactaccg tgcccgcgaa
     2701 gcaaacgtct atcgtctggc tgaagtgtca aactctatta tcgaccagtg cgtagcacag
     2761 ggtgtaccat tcgctcgcga atatggtggt ctgttggata accgttcatt cggtggtgct
     2821 caggtatccc gtacgttcta tgcccgtggt cagaccggac agcagctgct gttgggtgct
     2881 tactctgcat tgagccgtca gattggtttg ggaaaggtga agatgtacac acgccatgaa
     2941 atgctggatg ttgtgaaggt tgacggacgt gctcgcggta ttattgcccg taatttgatt
     3001 accggtaaga tcgaacgttt tgccgctcac gcagtcgttg ttgcgacagg tggttatgta
     3061 aatacattct tcttgtctac taacgcgatg gcgtctaacg gttctgctgc atggcagtgc
     3121 tacaagaaag gggcttactt tgctaatcct tgtatggtgc agatccaccc gacttgtgtg
     3181 ccggtgaaag gtgacttcca gtctaaactg actttgatgt ctgaatcact gcgtaacgat
     3241 ggtcgcatct gggttccgaa gaagctggaa gatgcgaagg cattgcaggc cggaacaaaa
     3301 aagggaaagg atattcctga agcagatcgc gactactatc tggaacgtcg ttatccggca
     3361 ttcggtaact tggttcctcg tgatgtggct tcacgtgccg ctaaagaacg ttgtgatgcc
     3421 ggtttcggtg taaatagcac gggcttggct gtattcctgg atttctccga cgctatcaac
     3481 cgtctgggta aggaagtggt taaacagaaa tatggtaacc tgttcgatat gtacgaagag
     3541 atcacgaacg atgatccgta cgaaactccg atgatgattt atcctgcatt gcactactca
     3601 atgggtggtt tgtgggtaga ctatgaattg atgacttcta ttccggggct gttcgcaatt
     3661 ggtgaagcca acttctctga ccatggcgct aaccgtctgg gtgcttctgc tttgatgcag
     3721 ggattggctg atggttactt tgtattgcct tacacgatcc agaactatct gtctgaccag
     3781 atccaggttc cgcgctttag cactgacctg cctgaatttg tggaagcaga aaaggctatt
     3841 aacgcccgta tcgcgaagtt gatgaacgtg aagggtaaag aaactgtcga ttctatccac
     3901 cgtaagctgg gacatatcat gtgggaacac gtcggtatgg cacgcgacgc ggaaggcttg
     3961 aaagaagcta tccaaatgtt gaaagacctg aagaaggaat tctggagcaa tgtattcatt
     4021 ccgggtgaag cgaacagctt gaacgtggaa ttggacaagg cattgcgttt ggctgacttt
     4081 atcgaaatcg gtgcattgat ggcacacgat gcgttagacc gcgcagaatc ttgtggtggc
     4141 cacttccgta cggaacatca gaccgaagaa ggcgaagcta tgcgtcatga cgataagttc
     4201 atgtacgtct cttgttggga ataccagggt gaagacaaag acccggttat gctgaaggaa
     4261 gatttgaact atcagttcgt tgttcctcaa acacgtaact acaagaagta ataatcatca
     4321 atcacaaaaa ttagaatcat ggataaagat ataaaggtaa cacttaaagt ttggcgtcag
     4381 aaaggtccga aagataaagg acagtttgag acttaccaaa tcgacaaaat caatcagagt
     4441 gtttctttct tggaaatgtt agacattttg aatgaacgtt tggttagcga aggtaaagaa
     4501 cctatcgtat tcgaccacga ctgccgtgaa ggtatctgcg gtatgtgttc attgtatgta
     4561 aacggacatc cgcacggacc ggcaacaggt gcaacaacct gtcagctcta tatgcgccgt
     4621 ttcaatgatg gtgagacgat tacgatcgag ccgtggcgtt ctgccggttt cccggtaatc
     4681 cgcgacttga tggtagaccg ttatgcttat gataagatta tccaggcagg tggtttcgtt
     4741 tctgtaaaca caggtggggt tcctgatgct aatgcaattc ctatttctaa ggctgatgcg
     4801 gatttggcta tggatgctgc tgcttgtatc ggctgcggtg cttgtgctgc tgcttgtaag
     4861 aacggttcag ctatgctgtt cgtctctgca aaggttagcc agctggctct tttgcctcag
     4921 ggtaaggtgg aagctgctcg tcgtgcaaaa gcaatggttg ctaagatgga tgaactgggc
     4981 tttggtaact gtacgaacac tcgcgcttgc gaaatggaat gtccgaagaa catctccgtt
     5041 agcaacatcg ctcgcttgaa ccgcgagttc atctctgcta agttacaaga ctaatacatt
     5101 atatatatgt atatggaaaa gcccgtcgtc aatggcaacg ggctttcttt atgttcgttc
     5161 aaacccacaa aaaagccgca ctccctataa taaaagtgga tgcggctttt ttgttgcttt
     5221 ccagtgaaac agtctctcga ttccctctct gcaaagactt tgttaacctt agatctaaaa
     5281 tactatgaaa aaaactcact gcaaatataa agtatattta ctgaatacgc aagagtttgt
     5341 aattacattt tattgcaaat ttgctacttt ttgttttaaa attgacactg tgtgcggatt
     5401 cacactgtta ttatatcaac aatcgatcga ttctgacact tgagagtcgc tttgaaatcc
     5461 gtatcctgta tgaaatttgt cggggatgga atccagaatg tcgaataatg cttccactgt
     5521 ttccgcacgt agcatggcga cgcgtgtctg cttgaagtct gcaatacctt taaacagcgg
     5581 agttgcagcc aaatggcggc gaatgtggag aattccccgg cgctcatcca aacgttccac
     5641 gctttgttcc acctgctttt tcagtatgtt cagataccat gaaaaagatt cggcaggcaa
     5701 tgtctcgcct gtatccagat aatgcctcac ttctctgaaa atccaggggc ggcctatgct
     5761 gccccggcca atcataacgg catccacgcc atattgttcg aaacgttgtt tgcagatttc
     5821 ggcggaagtc acatcgccat tgccgatgat gggaatttgt atgcggggat tgttttttac
     5881 ttcaccgatc agtgtccagt ctgcctctcc tgtatacatc tgtgcccggg tacgtccgtg
     5941 gatggaaagg gctgcgatac cgcaatcctg tagctgttcg gccaagtcta cgatgatccg
     6001 gttgtcggca tcccagccca agcgggtttt tacggtgaca gggatgttca ccgctttgac
     6061 gacttcacgg gtgatgtcca gcatcagtgg aatattgcgc agcatgccgg cgcctgctcc
     6121 tttgcctgcc actcgtttga cagggcaacc gaaattgata tcgagaatgt ccggatgagc
     6181 ggcttcgcaa atttgcgcgg cttcgaccat tgtcggaaca tcacggccat atatttgtat
     6241 ggcgaccgga cgttcttcat ccgccacatt cagcttttgc tgtgttttat ttacactgcg
     6301 gatcagggcg tctgctgaaa cgaattcggt ataaaccata tcggcaccaa aacgtttgca
     6361 catcaaccgg aaagaaatat ctgtaacgtc ttccatcgga gctaagaaga cggggcgttc
     6421 gcctaaatct attgtaccta ttttcatatt tatattatca atgacgggga caaaggtact
     6481 gatttcctgc taaaaacagg gataaaagga tatctactaa aaagtgtagt aattgatcaa
     6541 tagaaagtac aaatgtcata ctgtcaatga tatagataaa atgataagct gaaatcatga
     6601 tagttgcatg atagtagtat gatagttaaa aatagaaact atcatgtctt aaggtattga
     6661 ataacagatt ctaaaggaca acaatgacag tatgatggtt gttttgcaaa tctttataga
     6721 aaatggtatt tgatcacgat tttgatgctc tgagaaacgg atacccatgc aattcttctc
     6781 ggatattatt cctacctttg cgaacgaacc agtaaatgta taagaacttg aacgagaaag
     6841 attttgaaat aatggcgcct gtcggttcgt acgaatcact gatggcggct atccaagggg
     6901 gagccgattc tatctatttc ggtatcgaag gattgaatat gcgttcgcgc tcttccaata
     6961 actttacgac agacgatttg cgcaagatcg ttgcgctttg tcgtgagcac ggtattaaga
     7021 gctatttgac cgtcaatacg gttatttatg gggaagacct gcctctgatg cgcgagatta
     7081 tcgatgcggc gaaggaggcg gaagtttcag cgatcattgc ggccgatgtg gcagctatga
     7141 actatgccaa cagcatcgga caggaggtgc atctttccac acagctcaac atttccaatg
     7201 cggaagcact gaaattctat gcccgttttg ccgatgttgt cgtcttggcg cgtgagctga
     7261 atttgaaaca ggtgcatgaa atctatcggc agatcgtcga ccagcagatt acgggaccga
     7321 aaggagaact gatccgtatc gaaatgtttg cccacggagc tctctgtatg gccgtttccg
     7381 gtaaatgtta cctgagcctg cacgaaatga acgcttccgc caaccgggga gcttgcatgc
     7441 agatttgtcg gcgtgcttat tcggtaaaag ataaagacag caatatcgaa ctggatatcg
     7501 aaaaccagta tattatgtcg cctaaagacc ttaagacaat tcatttcatg aataagatga
     7561 tggatgcagg tgtacgggta ttcaagatcg aaggacgtgc ccgcggtccc gaatatgtcc
     7621 gcctggtgac cgaatgctat aaggaagctg tgcgtgctta ttgcaatggc acgttcgatg
     7681 aaaagaaagt tgccgcttgg gacgaacgcc tgcgcagtgt gttcaaccga ggattctggg
     7741 acggctatta tttggggcaa cggttgggtg agtggagtag caaatatggc tccggcgcga
     7801 ctaagaagaa agtgtatgtt gccaaaggaa tcaaatattt cgacaagatc ggcgtggcgg
     7861 agttcgaaat ggaatccggt aacctgaaag tgggtgatga gatcctgatt accggaccga
     7921 caacgggtgc ggttatgcag acgatagaag aaatccgtgt ggacttgaag ccggtggacg
     7981 agaccgttaa aggtgaacgg ttctctctca aggtgaacga gaagattcgg ccgtctgacc
     8041 gattgtataa aatggaaaag gttcaacttg aaaaggtatt tgaataatga aagagtatat
     8101 ttttaaactg acagacaagg tccgtgacta cgaatgcgac ctgcaaggag tggtcaacaa
     8161 ctccaattat cagcattata tggaacatac tcggcatgaa ttcttggagt cgcttggcga
     8221 gaacttcgga aagatgcacg aaaaaggggt tgacggattt gtatcgcggg tagaaatcca
     8281 gtataagacc tcgctcaaga gcggcgacag ctatatctct tgcctcaatg tctataaaaa
     8341 aggagtcaag ctcgtattcg agcaggatat atatagggct tctgacaatg cattggcgac
     8401 gaaaggaatc gtcgagtcgg ttatcgttga gaacggaaag ttgacacgcg gtgaatattt
     8461 cgacgaaatg ctaaaaagaa tagaacatac atgactgaca aacggattta ccaaatcggc
     8521 cttactatga taaacggcgt gggagatatc ctggcgcgtc atctcctgca ggctttggga
     8581 gaagcagagg ctgtgtttac tgaaaagcaa cagttgttag gaaggatccc tggtatcggc
     8641 agcaatattg ctgccgaaat caaacgcccg gaaatcttgc aacgggcgga aaaagagttg
     8701 gcttttatcg agaaaaacaa tatttcctgt tattatctga ctgatacaga ttatccggtg
     8761 cgcttgagag aatgtccgga tgcccctata cttttctatt ttaagggaaa tactaacctt
     8821 gatgcgaccc gtatcatcag tattgtgggt actcgcaacg cgaccgaata tggtcgggag
     8881 cttaccgaat cccttataaa agacttggca aaagtgatcc cggacttgtt ggtcgtgagt
     8941 ggattggctt acggcatcga tatctgtgcc caccggaacg ctttgtacaa ccgacttccg
     9001 actgttgctg tgctggcgca tggcttggat cgtatctatc cttcctgcca tcggaatacg
     9061 gctgtcgaaa tgctggaatc gggcggtctg ttgaccgatt ttcccagcgg tacagaacca
     9121 gaccgtccaa atttcctccg gaggaaccgg attgtcgccg gaatctcgga ttgtacgatc
     9181 gtggttgaat cggcagaaaa aggaggctct ttggtaactg ccgatattgc attctcttat
     9241 ggccgggatg tctatagctt tccagggcgc atcggtgaca gccattccaa aggatgcaac
     9301 aatttgatcc gacaaaataa agccggcctg atcacttctg cggacgatct gctctccgct
     9361 ctttgttggg atatccaagc tggggctact tccgttcaaa cggagttgtt tttcgccgag
     9421 gcggaaacat tcacctcgga acaaaatccg gttttagcca ttatgcgaac gcggaatgag
     9481 atccatatca acgagcttgc ctcagtgttg gagataccgg tacatcaact ctctatgcta
     9541 ttgttcgaac tggaaataaa cgggaaggta aaagcgttgc cgggaaatct ctataagctg
     9601 tcctgaccgg ctttttcgta tacgatttgt atgtgggaga agaaacggaa cctctataaa
     9661 caattaaagg ctgtctcacg acaaccccta accaactttg ttaaccttaa atctaatact
     9721 attatgaaaa aaccacattg caaagataca ctcgtcaaga gcgtttgtca agcattttgt
     9781 cgctaatact tgttaatcag atgagcataa atagcaaaaa gattttaatc ggctataaag
     9841 agtcctttaa actgcgttat tttgttaaat cgagtccttg aaacaggtac ggatagtccg
     9901 tttcgatcac gtcgggacga gtgctgatct ctgaccggta accggcggtt ttctctgttt
     9961 ccgttttcgc gcgatcatgt gtcggagcaa cggaaatcat gcacatgact ccgttacggt
    10021 gcagagcgtc atacagtggt tgctgttcag gcttcatctt cgggcctaca taagccatta
    10081 cctgtttcca ggggatgccg gctttttcat aattatcgaa ttcttcccga ttcttacacc
    10141 agcaagaaaa catcgcatcc ggtttccggt cgagataata gcgggcttga ctggcgttat
    10201 gtaccgtgta catgacgtta acaggctttt ctgtttctat aaaatcagcc ataacttcta
    10261 aaggtacatc cttgatatcc aaattcagga ttgttttgcc tttgctccat tccaggcatt
    10321 cttttaaagt tggaattttg aaggctgtca cgttgccgtt tcggtccacc agattgaatt
    10381 gttgcagttc tgcataagtg taatctgaaa cctttccttt cccggtagtt gtccggtcga
    10441 tggtttcgtc gtgcatcaat acgattatcc cgtcttttgt caaacgcgga tctatctcga
    10501 aaaacgattc catataggac aaggtctttt cgaatgattc gatgcagttc tccggatagc
    10561 cgtctagcat tccaccacga tgtccactga ttacaatcgg gcgatcggga gcataccgga
    10621 aataggcttg tagatcccgg ctgttcttca cagtaatgta atgaggattt tgttctttgt
    10681 ctgaagccaa aagattcccg gcaggcataa aaccccctaa aaggagtacc aaaataaaag
    10741 atagcatttt catgatattg tatttatata gattctttgt caattatgcg gcttaaaagt
    10801 aagacttttt tatcagtggc gtactataaa agcactataa aaacatgaaa atatgacagg
    10861 caacaagatg tgcaaagaaa gaggcaggta tataaaaaat taaggattgt catctcgaca
    10921 acccctaacc aactttgtta accttaaatc taatactatt atgaaaaaac cacaatgcaa
    10981 aaatacacta gctaagcttg tttgtcaaac cttttacgga taatatatgt taagctctaa
    11041 tagctatttt gtcaaaaaat gttggttatt tataaactat acagattcca tgtaaaaact
    11101 gctaattcaa atacttttta tcgtcggaaa aagtgaaatc ccatgcttaa aaagtgtccc
    11161 cttggagtat ataaaatcat taattaatat aggggatgct ttggtgtggc tgcttataga
    11221 taaattcctt tttggcgcat gcagcgaata gatgatagat tattaattgt taatacaaat
    11281 taacgcatta tttcttgcac atttacgatg tattcgtaga tttgcgatac gatcgtaaaa
    11341 aataatatag aaacatggaa agattaacaa gacaggaaga ggatgtaatg cgctggatct
    11401 ggcagatcga gccgtgtttt atcaaagaca tcctggcgaa gtatgaagag cctaagcctc
    11461 cttatacgac actcgcttct attgtgaaga atctggaacg taagaaatac gtgaaagcga
    11521 aacgttacgg aaatacttac gaatacaggc cgctgatccc acaggaggaa tataaacgga
    11581 cgtttatggg aagtgtggtg aacaactatt tcgagaactc ttacaaggaa atggtctcct
    11641 tttttgctaa agaacagaag atatcgaccg atgagttgaa agagattatc gatatgattg
    11701 aaaaaggacg agaataaact gttaaataca taatgccatg acaccggaat ttgcctactt
    11761 cttgaaggta aatgtagctt ttatactcct ttatgccttc taccggctgt tcttttataa
    11821 ggacaccttc tttaaactac gccgtaccat cttgttggca tttttcgggg tgtcattgct
    11881 ttatccgctg atgaatattc aggattggat ccgggagcag gggccgatag tggaagtcat
    11941 acaaatgtat tcagccattt tgcccgaaac gacaataacc cccggcaatg ttccccaaac
    12001 aaattggcat gatttgttac ttcccggtat ttcttatctt tattggagcg gtgtaattgc
    12061 cttatcgttc cgttttttag tgcagttgag cagcatcttg ttactggcac ggcggtcgga
    12121 agtgactttg atccgtaacg tacgtgtaca tctgttgaat aaaccggccg gtcctttttc
    12181 ttttttccgg ctggtatttc tgcatcccga cagccattcc gagaaagaga tcgatgagat
    12241 tttggtacac gagtgtacgc atgtcagcca gtggcattcg attgacgtga ttatttgcga
    12301 attggtttgt atcatctgtt gggtgaatcc gtttgtctgg ctgttgaaaa gagaggtacg
    12361 tcataatctg gaatatttgg cggatgatac ggtacttgaa tcgggctatg acagtcgtag
    12421 ctaccaatat caccttttgg ggttggcaca taccaataga tcggtgacct ctttatctaa
    12481 taactttaat atgctgcatc tgaaaaatcg gatcagcatg atgaataaga aacgttcccg
    12541 gagcataggt aggacgaaat acttgatttt tataccggtt gtgggcgcct tgctgatttt
    12601 aagcaatgtc gatgcattgg cccggatcac ggacgaactg acggaaagca cgtttgccga
    12661 tgtcttgcta ccggaggcta tcttgccgtt cccttttgtc ggtgatgctt ctcctgctga
    12721 aaaacgtgag gagtatgtgc tatcggagga aggtattgag gctgccagac gtgcccgtaa
    12781 cccggtgttt accgttgtgg aggtaatgcc ggaattccct ggcggacagg gtgctctgct
    12841 gaaattcctg gcgacgaatg tcagataccc ggaatcggcc gttaaaaatg gtatagaggg
    12901 acgggttagc tgttctttcg ttgttggaaa agacggggct atctcggagg cagaagtgat
    12961 tcgtggggta agtccggaac tgaatgagga ggctttgcgt gtgataaact ccatgccggt
    13021 atggtcgccg gggaaacagc ggggcaaagt ggttaatgtc aaatatacgg taccggtaac
    13081 tttccggctt tccggtggaa agaaaaaaac atcctctcgt atcgtgcaga ggcagattaa
    13141 agaagtcgat acgtccggtc gtgtctttac ggtagtgcaa cagatgccgg aatttccgag
    13201 tggacaggct tcgttgttga aatatctggc aacacgcata aaatatccgg ctattgctca
    13261 ggagaatgga atacaaggac gtgtctcttg ctctttcgtt gtcgacacgg atggaagttt
    13321 gaaaaatatt gaagtgatcc gtggaatcga tccttcgctg gacagggagg ctgtccgggt
    13381 gatccgggaa atgccgaaat ggaatcctgg cgtacaaaac aatatggctg tagccgtaaa
    13441 atatacggtt ccggttactt tccgtttgca gtaattgacc agaatcggtc attaatacga
    13501 taccattatg aaatgtaagt tttctctatt actgtttctt tgcgtactgt ccctttgggg
    13561 acaggcgcag agtcttaatc ttcaggaatt ggtcaataaa aaacaatttc aggaagttgt
    13621 agcacgtgcg gatagtctta ctcctgccga ttcagccgat tatgctacaa tgtcggcaat
    13681 cgggcaggcg tatgagggac tgttgcgcta taaggaggcc tatcagtgtt tttctcattg
    13741 cttgaagatg gatacgaaca atgtggatgc attgaacgcc gttgccagga atgcgatcaa
    13801 tttcggaagg atagcggaag ctaaacaatg ttatcgtaaa gtattgggaa ccgacagcat
    13861 gaacttctat gccaactatc agttggcgcg tctctattat cagttgggag attatggtcg
    13921 agcgacggaa cactatcata tacttgcttc catcgaaggt gaaaatcctt ctatcctgac
    13981 cgggctggct gattgccata ttaaaagagg gaccggtcct aatacgatga tcgctctttc
    14041 tttgtatgcc cgtgctttgg agctgaaccc ggaaaatgta cgtgtggcat cttctctgat
    14101 aaatacgtta ttgcggatgg gggacggaca gggagctttg caggtgtgcg ataccgcctt
    14161 gttctataat ccggataaca gccagatacg gcagagtaaa gggatggctc tctatatgac
    14221 gaaagattat aagcaggccg attcagtcta taccggtcta ttggccgatg gcgattcttc
    14281 ttttttgaat cttaaatatg cgggggcggc ccgctatatg tccggtcatg cacttgatgg
    14341 ggtcgagctg ctggagaagg cctatgaaat agattcgacg gatgtggaaa cagtcatgtt
    14401 gtatggcgct tccctgggaa aaacatacga ccgtaaacgg gcttatgagc ttttcgatct
    14461 ggcggaaacg aatatgcagc cgaaaaaatt cctagttaat atgttgacga ccttccgagg
    14521 tgatgccttg gaaagggacg gccgttggcc cgaagcggaa aagctgtatt atgccgcatg
    14581 gaaggaagac ccaacccagt tgcacttcct gtataagatc agtacacaat actgggatgt
    14641 cgatccggga ctctttcagc aggaggaaaa attgcaaaag acgattttca gtagatacac
    14701 ttacctgaca gcctatatga agacagacaa gtcgcaaaag tatctttata attaccgccc
    14761 tttcttggaa gcggtttgtg aagatgcctt tttccggaat gccgatgaag tgacgatgtt
    14821 ggctcccgat gggaagaaga cgaagttggc tgtcgctgat ctgcgtgcct tggtcgccca
    14881 actgccgcag atgccggaag atgaacgttt gaggcgcgag aagatgcagg aacatattaa
    14941 aaaagccagg gaaaaagaaa aggaattgcg taaaagcggt gctaaactcg atacgctcgc
    15001 cctgagtaag gaagaaaaag agaaagcacg gaaaatgttg aaagacgccg acttggaata
    15061 gatagaatat ctgaacaata taatcgatat aaat
//
