LOCUS       c00033_gnlPro..        12863 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HMNNPHKN_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:29:18
            Original ID  :: gnl|Prokka|HMNNPHKN_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12863
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..240
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 62; E-value:
                     1.2e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_1"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.3e-20, bitscore:
                     62.0, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PAPAPAAAGAGDVPSPLAGKVVSLDVAAGASVKAGDQILTLEAMK
                     MNTIIYAPASGTLTAFCVNPGDTVQEGQALAKIG"
     protocluster    1..12863
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2860:12863]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2861..12863
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..12863
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12863
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             358..1983
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OAD_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_2"
                     /sec_met_domain="OAD_beta (E-value: 1.1e-159, bitscore:
                     520.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTSTSLNNVGYLRVHVAPLQQTPAKVPANLTTPEAR
                     AQYLETMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLKNGEGTTVVRQQGVNYFDTSGNRVPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFNPNEAASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERVIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQAETLLIILLGIVAF
                     GVATAGGVIAAKLMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             2021..2800
                     /locus_tag="ctg33_3"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARSLPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPADTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVSALQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             2861..4357
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hyd_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hydro"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_4"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 6.8e-47,
                     bitscore: 148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 4.8e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             4477..5178
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGAGATAAALIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSRITRNLSMLAFLPALYALLIPFAGM
                     PVPSQYTEMDRVWEAFLLLASVISFFSFPYTAGYGAAGRRLFLAWGIAAAGCGSQSALF
                     FLALLLRQFLSTAVPSLAAPISWLAVLLSCGLEIMLAALSVILARRLFKEVMSIASMPE
                     PIDPSMPGNLP"
     CDS             5237..5485
                     /locus_tag="ctg33_6"
                     /transl_table=11
                     /translation="MNTRTAHGSLLPTRLPHPGMKGFYGFEQTTAGNFRKYGHRMESIA
                     GKQTAPTENRGICRVAPSISLADPRQPYFTNSSKYRP"
     CDS             complement(5452..6315)
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLR
                     PKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISPETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(6325..7377)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_8"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 8.3e-99, bitscore:
                     320.7, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYRFLHADVRDASLMRRTLREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQAALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPALITNCSNNYGPYQFPEKLIPVVILKALGGESIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWIPRQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             complement(7509..8453)
                     /locus_tag="ctg33_9"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKKRNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDIAGTDYCLGVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             8582..9313
                     /locus_tag="ctg33_10"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFEAPVHVTYNPLTYAWGPHEQY
                     VRTYGNGEKSHLFLGMNPGPFGMAQTGVPFGEVDAVVNWLHIRGEVGRPEHTHPKRPVE
                     GFSCPRSEVSGRRLWGLFAEAFGTAENFFRHNYVANYCPLIWMGATGANITPDKLPTEQ
                     RAAVDAVCMEHLLSLITILNPHTLVGVGAYATQKLRDAASRLPGKSFTIGTLLHPSPAS
                     PIANKLWPERPIQQLKELGIL"
     CDS             9678..11144
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MAISDYIVTIGLEVHCQIKTKSKMFCSCETGFGFEPNTRVCPTCL
                     GLPGALPVLNEFAIERTLLTGLMLGCSSPEISQWDRKNYFYPDMAKNYQTSQLDLPLCL
                     GGEVPLYPWSYPNDVIKAGVPPFRTVKLTRIHLEEDAAKITHHANYSLIDYNRAGSALM
                     EIVSEPDIDTPEEAYAYLKSLQQILNYGDISDADMEKGQMRCDVNISLRPHGQEELGAK
                     VEMKNINSMSAVRRALHYEIRRQAEELDMGIPQIQSTRRWDDERGESVVMRTKEDAHDY
                     RYFPCPDLVPVRTAPLVEKVRGQIPELPQERQKRFMEEYGLSEYDANVLVGDLELAHFF
                     EEAARGTASGKKIANWVINNISAVLNEKGMRPSECPVKPGAIRELIAIIDDGTVSNNQA
                     KDVFAKMWDEPALAAAQAAKLLGFEKADSSFLDGIVREVISANPDKVAEIQGGNEKLLN
                     WLTGQVMKAAKGKVNPKIVTEALKKALSME"
     CDS             complement(11199..12863)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_12"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.4e-33, bitscore:
                     104.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="IVGDSLNPVTDALRRRKTIEWIHVRHEEVAAFAASAEAQLSGNLA
                     VCCGSSGPGNLHLINGLFDAHRNHAPVLAIASHIPQSQVGMEYFQATHPEQLFKECSAY
                     AELVSEASQAPCILMSAIQHAWARRDVGVVVLPGDIADAPAEMKNLVHPPSYTRENVVP
                     EHESVSLLARMLDDHRRITFFCGAGCAGAEDKVVRLAHRLKAPIAYTWRGKDYFEHDNP
                     LGIGMTGLLGWGDAYKAMHESDMLVLWGTDFPYFNFIPTKPEIVQIDRRGEVLGRRCRL
                     DLGICGDVSVTAEALLNMVQEKTDSGHLDAALKRHARDVKEMNAYMEGNDKESPIRPEQ
                     LTTALNRHAASDAVFTVDTGTPCIWSARFLCATLGRRTLASFNHGSMANAMPMAIGAQM
                     EYPGRQVIALCGDGGLSMLLGDLITIVQYRLPVKIVVYNNDCLDFIQLEMQAAGLIPWQ
                     INLNNPSFAAVADAVGIKGFLLDKSSQVDQMVNMFLNYPGAALLDAHVDRDALALPPYI
                     SMGQAADFSLAMMKQTLAGEVKQVWNTLAGNRKLFKP"
ORIGIN
        1 cctgctccgg ctccggccgc cgccggcgcc ggagacgtgc ccagcccgct tgccggcaag
       61 gttgtttccc tggacgtggc cgctggcgcc tccgtgaagg ccggcgacca gattctgacg
      121 ctggaagcca tgaagatgaa taccatcatc tacgctcccg cctccggcac gctcaccgct
      181 ttctgcgtaa acccgggtga tacggttcag gaaggacagg ctctggccaa aattggttaa
      241 tcccggcggc aaccgcccgg aacctccaac agttcctggc tccgactcag ataacaaacc
      301 gctacaataa cattccgtat gagtcttttt gattcattaa tcaccttttt acaggggatg
      361 ggcatcttct ccctatcatg gcaaatggta gggatgtggg gcattgccat cctgctcctg
      421 tatctgggtg tagccaagca atacgaacct ctcctgatgg ttcccattgc tttcggcgcc
      481 ctcatcgcca acattccgga caacggaatg ctcatcaccc agctgaacca gcaggtcatc
      541 tcctccaatg aacaggggga agtaacctcc acgtccctga acaacgtggg ctacctgcgc
      601 gttcatgtgg ctcctctgca gcagacgccc gccaaggtgc cggccaatct gaccacgccg
      661 gaagcccgcg cccagtatct ggaaaccatg cagcagccca tgcaggttta tcccggcagc
      721 cagctgaccg tttccaaaat caagtccgtg cgggaatccc aggaaaaagc caaagctgac
      781 gccgcccgcc tgggagacga cagtctgacg gtggatccca acctgaagga cttccagaac
      841 gtgacggagg acaacggcaa tgagccggtc ttcctgctca agaacggaga aggaaccacc
      901 gtcgtccgcc agcagggcgt caattacttt gacaccagcg gcaaccgtgt tcccgtggac
      961 ctgaaaacgc agaagctgga acccctggtg gtttccgccg caggcaaata cgtggccgta
     1021 ggccaacata cccaggaact gctggtcacc tccatccacg ggggcctgta tgactggatc
     1081 gggctgggca tcaaggctga aattttcccg cccatcatct tcctgggcgt aggagccctg
     1141 acggacttcg gcccgctgct cgccgcaccg cgcaccctgc ttctgggcgc ggcggcccag
     1201 gtgggcgtag ccgccacgtt cttcatggcc ctgttcatgg gcttcaaccc gaatgaagcc
     1261 gcctccatcg gcatcatcgg cggagctgac ggccccactt ccatcttcct gacgatgaag
     1321 ctggctccgc acctgctggg cgccgtggcc gtggccgcat acacgtacat gtccctggtt
     1381 ccgctgatac agccgcccat catggcgttg ctgacgacca agaaggaacg cgtcatccgc
     1441 atgaaatccc tgcggacggt cagcaagagc gaaaaactgt tcttcgccgt gctggtaacc
     1501 attgtcacca ttctgctgat tccggacgca tccccgctca tcggcatgct gatgctcggc
     1561 aacttcctgc gcgaatgcaa ggtgacggaa cgcctggttc aggcctccca gaatgaaatc
     1621 atcaacatcg tcaccatctt cctgggaacc tccgtgggtc tcacgatgca gggagaccgc
     1681 ttcctgcagg cggaaacgct gctgatcatt ctgctgggca ttgtcgcctt cggcgtagcc
     1741 actgcgggcg gcgtcatcgc cgccaagctc atgaacctca tctggcgcaa gaatccggtc
     1801 aaccccctca tcgggtccgc aggcgtctcc gctgtcccga tggcagcccg cgtctcccac
     1861 aatgtgggcc agaagtacga cccctccaac tatctgctca tgcacgccat gggcccgaac
     1921 gttgcaggcg tgatcggcac cgcagtcatc gcgggctact acatcgccac tctggcgaaa
     1981 taaccagaat tgaaaattac tcccggcctc ggcccgtccc atgaattccg cagcctcatt
     2041 ttccacccct ccggaggagg aaggaccatg cggcgactgg acttatcatg aatgggccga
     2101 ggctttttcc accaatgacc tggcccgctc cctgcccccg ggacatattg ccgtctgccg
     2161 cgttcagaca ggaggccgcg gcaggttcaa ccgcaaatgg ataggggagg aaggcggcct
     2221 gtgggcatcc ttcaccgttc ccctgtccgc tcctgcggat acagcggccg gcgtgcactg
     2281 gggccatttg cccctggttg cggggctggc cctgttcaac atgctccgcg gcatggggct
     2341 ggattccgtg cgcctgcgct ggccgaacga cctgctggcg ggcaaatcca aactggcggg
     2401 aatactggtg gaacgcccgg cggagaacat ggccgtcatc ggcatcggca tcaatgtttt
     2461 caatgatgta tcctccatcg ccggggaaat caaggaccct ccggcaaggc tggcggatct
     2521 tgttcgggac tgcccttccc tgcacgccgt catggcttct ctgggcagtc atttgaacca
     2581 ggttctttcc gtcttttccc acggcggcgt ctctgccctt caggagggtc tgtcccgggc
     2641 atgggccgga gaaaggccgg tttccattct tacggatgac gaaaccgtcc ggggcatttt
     2701 tacagggatt gacgatcagg gcaatcctgt gctatccctt ccggccggca ccgtccgcac
     2761 cattccggcg cacctgatca acaggctcct cgaagaatga gcctaccgct ccgttgttac
     2821 acggggtttc tttctttttc atccaacaaa aatcactgac atgagttaca aggtactgac
     2881 accagaagaa gcagcaagcc tgatcaagca tggccaccat attgggctga gcggattcac
     2941 gcccgccgga acggccaagg ccgttacggc tgcgctggca aaaatcgcag aagcggaaca
     3001 tgagaagggg aaccctttcc aggtgagcgt cttcaccggt gcttccaccg gcgattcctg
     3061 cgacgggatc ctttcccggg ccaaggcaat ccgctaccgc gctccctaca ccaccaacgt
     3121 tgatttccgc aaggcggtga acaacgggga aatcgcctat aatgacatcc atttgtccca
     3181 gatggcccag gaagtgcgct acgggttcat gggcaacgtg gacatcgcca ttattgaagc
     3241 ctgtgaagtc acggccgacg gcaaaattta cctgacggcc gcgggcggga tcgctcccac
     3301 catctgccgc ctggcagaca aaattatcgt ggaattaaac gccgcccaca gcaagagcgc
     3361 catgggcctg cacgacgttt acgaacccct ggatcctccc taccgccgcg aaatttccat
     3421 cttcaaacct agcgaccgca tcggcaagcc gtacatccag gttgacccga aaaagattgt
     3481 gggcgttgtg gaaaccaact ggccggatga agcccgttcc ttcgccgcag cggatcccct
     3541 gaccgataaa atcgggcaga acgtggccga tttcctggct gccgacatga aacggggcat
     3601 cattccctcc acgttcctgc ctctccagtc cggcgtgggc aacatcgcaa acgcggtgct
     3661 gggcgccctg ggccgcgaca agacgattcc cgcgttcgag atgtacacgg aagtcatcca
     3721 gaattccgtc atcggcctga ttcgggaagg ccgcgtgaaa ttcggcagcg cctgctccct
     3781 gaccgtgacg aacgactgcc tggaaggcat ttacagggat atggactttt tccgcgacaa
     3841 actggtgctc cgtccctcgg aaatatccaa cagcccggaa gttatccgcc gtctcggcgt
     3901 catctccatc aacaccgcca ttgaagccga catttacggg aacgtcaact ccacgcacat
     3961 tggcggcacg aagatgatga acggcatcgg cggatccggc gacttcacgc gcaacgccta
     4021 catctccatt ttcacctgcc cgtccgttgc caaggacggc aagatcagcg ccatcgtccc
     4081 catggtttcc caccatgacc atacggaaca tgacgtcaat atcattatta ccgagcaggg
     4141 ggtcgcggac ctgcgcggca agagcccgaa agaacgggcc cagaccatta ttgaaaactg
     4201 cgtccacccg gattacaaaa acatcctctg ggattacctg aagctgtccg acggcaaagc
     4261 ccagacaccg caatccatca gggccgcttt gggcatgcac gccgaactgg ccagaagcgg
     4321 agacatgaag aatgtcgact gggcccagta taagtaattc cgcatgccgt cattcgcatt
     4381 ggcatccatg aattcacgtt aacccctcag gaccgcttcc gcaaagggag cggtcctttt
     4441 cctttttccc atcccctcta ctctcttctc ttcaccatga actggatgat ttacccggca
     4501 gccagggctt tcatcaaagt ctgcgccgtt cttttcggcg cgggcgcaac agcagcagcc
     4561 ctcatccatc tgttcatgcc ttttttcctc cgctctcccc ggacagccgc gcccttcctg
     4621 cttttgggaa caggggcgga attgctctcc atcctttccc tgtccttcct catgttctgg
     4681 ggcgccagag tcctgctggc ctcccgcgga agcagaataa caagaaatct gagcatgctg
     4741 gccttcctgc ccgccctgta cgccctcctc attccgtttg cgggcatgcc cgtcccatcg
     4801 caatatacgg aaatggacag ggtttgggag gccttcctcc ttctggcgtc cgtcatttct
     4861 ttcttttcct tcccttatac ggcgggatac ggcgccgcag gcaggagatt attcctggcc
     4921 tggggcatcg cggcggcagg atgcggttcg cagagcgccc tgttttttct tgccctcctg
     4981 ttgcgtcagt tcctgtccac agcagttccc tccctggcag cgccaatttc atggctggcc
     5041 gttctcctgt cctgcggcct agaaatcatg ctggcggccc tttccgtcat tctggcgcgg
     5101 cgcctgttta aagaggtcat gtccatagcc tccatgccgg aaccgattga tccctccatg
     5161 ccgggcaacc ttccctgact tcccccctgc cttcatgttt gcagccagtt ggaagggatt
     5221 acccccagtc cgcggcatga atacgcgaac cgctcacggc agccttcttc caacccggct
     5281 gccgcatccc ggcatgaaag gcttttacgg ttttgagcaa acaacggccg gaaatttccg
     5341 caagtacggc caccgcatgg aaagcatcgc cgggaagcaa accgccccca cggaaaaccg
     5401 cgggatttgc agggtcgccc cttccatttc ccttgcagac cccagacagc cctatttcac
     5461 caattcatcc aaataccggc cataaccgtt attattcatg gctccggcct gggaacgcag
     5521 cgtttccggg gaaatccagc cgttattaaa ggcaatctcc tccaggcacg ccaccttgaa
     5581 cccctggtgg tgctccaacg tgcgaacgaa catggaagcc tccagaaggg tatcgtgcgt
     5641 gcccgtatcc agccacgtat agccgcgcgc cagcttttcc acgcgcaaca ggccctgctt
     5701 caggtattcc tgattcacgg aggtaatttc caactcgccc cgggaggact tgggaatcct
     5761 tttggctatc tccaccaccc ggttgtcgta aaaatagagg cccgtcaccg caatatccga
     5821 tttgggccgg agcggttttt cctcaatgga aaccgccttc ccctcctcat tgaattccac
     5881 taccccgaaa cgctgcgggt catgcacctg gtaaccgaaa atggtcgctc cgctcgtcag
     5941 ttcggcggcc cgcctcagct tctccgtcag gccgcgcccg taaaaaatat tgtcccccag
     6001 caccagggct acggaatcct ttcctatgaa ctcctctcca ataataaagg cctgagccaa
     6061 tccctccggc ctgggttgtt ccctgtattc aaaggaaacg ccgaacctgc tgccgtcccc
     6121 cagcaaatcc cggtacaggg gcagatcccg gggcgtggaa ataacaagga tttcccgtat
     6181 tccggccagc atcagcacgg agatgggata ataaaccatt ggcttatcat aaacgggcag
     6241 caattgcttg ctgacggaaa gcgtaacggg atgcagccgc gtgccgcttc ccccggccag
     6301 aacaataccc ttcatatcaa attcctagcc attggttcca agacgttcca ggcggtattc
     6361 cccggacagg atgccccgcc accattcctc atggtccaga taccactgaa tggtctttct
     6421 gaatccggaa gaatggtcct ggcgcggaat ccatcccaat tccctccgta ttttggaagc
     6481 gtcaatcgca tagcgcaggt catggcccgg cctgtcctgc acaaaggaga tttgctcccg
     6541 gtagctccgg ccgtccggcc ggggccgcag ttcatccaga tgggaacaca gcagctccac
     6601 cagctccaga ttggttttct cgttattgcc gccgatgttg tacgtttccc ccggttttcc
     6661 gcaggaaacg accgtcagca gcgcctcgca gtgatccccc acatacagcc agtcccgcac
     6721 gttttcccct ttgccgtata caggaatgga ttccccgccc agcgctttca ggataacgac
     6781 ggggatcagc ttttccggga actggtaggg gccgtaattg ttggaacagt tggtgatcag
     6841 cgcgggaagc ccgtacgtat cgtgccaggc gcgcaccagg tggtcgctgg aggccttgct
     6901 ggcggaatac ggggaatggg ggcgatacgg cgtggactcc gtgaacaggc cttcctttcc
     6961 cagggagccg tacacttcat ccgtggaaat gtggtggaag cggaaacgct cctttttctc
     7021 tccctccagg gaacggtaat attccagagc ggcctgaagc atggaaaaag tgcccatgac
     7081 gttggtggtc ataaaatttc ccggatcgtc aatggaacgg tccacatggg attccgccgc
     7141 caggtgcatc acccagtccg gagcgtactc ccgcaaagtg cgccgcatca gggaagcgtc
     7201 ccggacgtcg gcgtgcagaa agcggtatgc cggagaatcc gccgagccgt ccagggaatg
     7261 gatgttgccg gcataggtca gggcgtcaat attcaggact tcatggccgc gctccagcag
     7321 cagcctgacc agattggagc cgatgaatcc ggcgccgccc gtaacgataa ctttcatagc
     7381 actgttttca gggaaagatg cggcgccatc atacagcaac ggtgtttttt ttcaaaacaa
     7441 atccgcccat gccgcgggaa cgtggcggca tgggcgggaa aaagcgggtt ccgtaaccgc
     7501 tgagacggct agcagctcag ctcccggcaa aggttgatga tatcctggtt cacggagtac
     7561 tgctgcccgg caacggaatc cagggaggca tagccgtact ggccgtcatg atacaccatg
     7621 atctggttga tgtccccgtt gttcagagct tccacggcgc gggtggcaaa acgggtgccc
     7681 atcaggcggt cacgggcagt gggggaaccg ccgcgctgca catggcccag cacggtcagg
     7741 cgggtatcca tgccggcgcg ttccgtcagc cagcgggtca ggtactgcgc cacgcgggtg
     7801 ccttccgcca ccacggcaat gatgcagctt ccttcctcat tgatgacagg ctggaggcgc
     7861 ttgtaaatgg attccaggtc atacggaatt tcagggacaa tgcagatatc cgccgcgctg
     7921 caaagagcgg tggtcatcgc cagatagccg cagtcccggc ccatcgtttc aatcacgaaa
     7981 gcgcggtgat gggaacgggc cgtatcacga acggaatcaa tgcaatccag aatcacgttc
     8041 tgggccgtat ccacgcccag gcagtagtcc gtgccggcaa tgtcgttgtc aatcgtggcc
     8101 ggaataccgg caaaaggcac ttcaaaatca ttgaaaaagt cgttcagggc gcggaaggaa
     8161 ccgtccccgc ccatgatgat gagcttgtcg atgttgcgtt tcttcagatg ctcgtaggcc
     8221 tgcttgcgga attcgtagtc gaaaaagcgc ttggatcgtg aggaacggag gagagttccg
     8281 cccctgtaga tcatatcgtt ggtcagttcc cgggtggctt ccttgatttt tccatcgatc
     8341 agcccttcca agccgtcata aacaacgtac gggttcatcc caagctggcg ggcatgatcc
     8401 actgccgcct tgatcgccgg gttcattccg gcggcatcac cgccagatgt cataatggct
     8461 attccactca taagtaataa ggttaacttg tccgggggga aatgttaccg ggcggaacaa
     8521 ataatgcaag cgcggagttt ttactggcgc aataaacggc aacgcttcat gatgcggagg
     8581 catgaacgac actgcagcag ccattctgaa agccacggcc gccctccggg acggcacgga
     8641 gaagctccgg ttcgaagccc cggtccatgt tacctacaac cctctcacct atgcatgggg
     8701 gccgcatgaa cagtatgtgc gcacctacgg aaacggggaa aagagccatc tgttcctggg
     8761 catgaatccc ggccccttcg gcatggctca gacaggcgtc cccttcgggg aagtggacgc
     8821 cgtcgtcaac tggctgcaca tccgcggaga agtcgggcgg ccggaacata cccaccccaa
     8881 acgtcccgtg gagggtttca gctgccccag gtcggaagtc agcggccgcc gcctctgggg
     8941 acttttcgcg gaagctttcg gcactgcgga aaatttcttc cgtcacaatt acgtggccaa
     9001 ttactgtccg ctgatctgga tgggagccac cggagccaac atcacgccgg acaaactgcc
     9061 gacggaacag cgcgccgccg tggacgcagt atgtatggaa cacctgcttt ccctcatcac
     9121 catcctgaat ccccacacgc tggtgggggt gggtgcctac gccacgcaga agctgcggga
     9181 cgccgcctcc cggctccccg gcaaaagctt caccatcggc acgttgctcc acccaagccc
     9241 cgccagcccc atcgccaaca agctctggcc ggaacgtccc atccagcagc ttaaggaact
     9301 gggcatctta taaaaagagt agaggaggca gagtggagaa ctccgtgaca tggaaggaat
     9361 caccagagca acaggccgga aatcggcagt tcatcttgtt cccctccaaa actacatcgc
     9421 tttgaaggaa tatccggccc ccttcactgg cttgattcgc ccagggacac ggccttcctg
     9481 acggaagaaa tgcacgccgg catctaccgg gacggagaag aacttaaacg cctccccacc
     9541 tccgccacaa aatcccccct ccaaatcaat catcattctt agtctgaaaa ccctccgctc
     9601 tcccccgcag gcctttttac tggacaggga gaaaagggtt ccgtacagtt tccgcgatct
     9661 tcaagcgttc cgaatttatg gcaatttcag attacatcgt gaccattggc ctggaagtcc
     9721 actgccagat caagacaaag agcaaaatgt tctgctcctg cgagaccggc tttggctttg
     9781 aacccaatac gcgcgtgtgc cccacctgcc tggggctgcc gggcgccctg cccgtcctga
     9841 atgaattcgc cattgaacgc acgctgctga ccggcctgat gctgggatgt tccagcccgg
     9901 agatttccca atgggaccgc aagaattatt tctatccgga catggctaaa aattaccaga
     9961 cctcccagct ggatcttccg ctgtgcctgg gaggggaagt gcccctgtac ccctggtcct
    10021 atccgaatga cgtgatcaaa gccggcgtcc ctcctttccg caccgtgaag ctgacccgca
    10081 tccatctgga agaagacgcg gcgaagatta cccatcatgc caattattcc ctgatcgact
    10141 acaaccgtgc ggggtccgcc ctgatggaaa tcgtttccga gccggacatc gacaccccgg
    10201 aagaagccta cgcctacctc aagtccctcc agcagattct gaattacggg gatatctccg
    10261 acgcggacat ggaaaagggc cagatgcggt gcgatgtgaa tatttccctg cgtccccacg
    10321 ggcaggagga attgggtgcc aaggtggaaa tgaagaacat caactccatg tccgccgtcc
    10381 gcagagccct tcattatgaa atccggcgcc aggcggaaga actggacatg ggcattcctc
    10441 aaatccagtc cacccgccgc tgggacgacg aacgcggaga aagcgtcgtc atgcgaacca
    10501 aggaagacgc gcacgattac cgttacttcc cctgtccgga tctggttccc gtacgcacgg
    10561 ctccgctggt ggagaaagtg cgcggtcaga ttcccgaact gcctcaggaa cggcagaaac
    10621 gcttcatgga agaatacggc ctgagcgaat acgacgccaa cgtgctggtg ggagacctgg
    10681 aactggcaca cttttttgaa gaagcggcgc ggggaaccgc cagcggcaaa aaaatcgcca
    10741 actgggtgat taacaacatt tccgccgtgc tgaatgaaaa aggcatgcgc ccgtctgaat
    10801 gcccggtgaa acccggcgcc atccgggagc tgatcgccat tattgacgac ggcaccgttt
    10861 ccaacaacca ggccaaggac gtattcgcca aaatgtggga tgagccggcc ctcgccgcag
    10921 cgcaggccgc caagctgctg ggctttgaaa aggcggattc ctcttttctg gacggcatcg
    10981 tgcgggaagt catttccgcc aatccggaca aggtggcgga aatacagggg ggcaatgaaa
    11041 aactcctgaa ctggcttacc ggccaggtca tgaaggccgc caaaggcaaa gtcaacccga
    11101 aaatcgtgac ggaagcgctg aaaaaagccc tttccatgga gtaaccataa acaaagagcc
    11161 gcttcccttc ccggtgtcct ctccttgccc gcagggcatc acggtttgaa cagcttcctg
    11221 tttccggcca gggtgttcca tacctgcttc acttccccgg ccagcgtctg cttcatcatg
    11281 gcaagggaaa agtccgccgc ctggcccata ctgatatagg gaggcagggc aagggcgtcc
    11341 ctgtccacat gcgcgtccag cagagcggcg cccggataat tcaggaacat gttcaccatc
    11401 tggtccacct ggctggattt gtccaataaa aatcccttga tgccgacggc atccgccacg
    11461 gcggcaaaag agggattgtt caggttgatc tgccacggaa tcagcccggc cgcctgcatt
    11521 tccaattgga tgaaatccag acagtcattg ttatacacca cgattttcac cggcagcctg
    11581 tactggacaa tcgtgatgag atcccccagc agcatggaca ggccgccatc tccgcacagg
    11641 gcaattacct gccgtccggg gtattccatc tgcgccccaa tagccattgg cattgcattg
    11701 gccatggagc catgattgaa ggaagccagc gtcctcctgc caagcgtagc gcacaggaac
    11761 cttgcgctcc agatacaggg ggtgccggta tctaccgtaa atacggcgtc ggatgccgca
    11821 tgcctgttca gggcggtcgt gagctgttcc ggccggatgg gagattcctt gtcatttcct
    11881 tccatatagg cgttcatctc tttcacgtcc ctggcgtggc gtttcagggc ggcgtccaaa
    11941 tgcccggaat ccgtcttttc ctgcaccatg ttcagcaacg cctccgccgt gacggaaaca
    12001 tccccgcaaa tacccaggtc caggcggcag cggcggccca gcacttcccc gcgcctgtca
    12061 atctgcacga tttcaggttt ggtgggaatg aaattgaaat agggaaaatc cgtcccccac
    12121 aacacgagca tgtcgctttc atgcatggcc ttgtaggcat ctccccatcc cagcagcccc
    12181 gtcatgccga tgcccagggg attgtcatgt tcaaaataat cctttcccct ccatgtgtag
    12241 gcaatcggag ctttcaggcg gtgcgcgagc cggacgacct tgtcttccgc tcctgcgcag
    12301 ccggcgccgc aaaagaaagt aatgcggcgg tggtcgtcaa gcatccgtgc cagaagggat
    12361 acggattcat gttcaggaac aacattctcc cgcgtgtagg aaggaggatg caccagattc
    12421 ttcatctccg caggggcgtc cgcaatgtct ccgggcaaga cgacgacgcc tacgtcgcgc
    12481 ctggcccacg cgtgctgaat ggcggacatc aaaatgcacg gggcctggga agcttccgaa
    12541 accagttccg catatgcgct gcattccttg aaaagctgtt ccggatgcgt ggcctggaaa
    12601 tattccatgc ctacctggct ctgtgggata tgggaggcaa tggccagcac cggggcatgg
    12661 ttccggtggg cgtcaaacag gccgttgatc aaatggaggt ttccggggcc gctgctgccg
    12721 cagcatacag ccagattccc gctcagctgg gcttccgcgc tcgcggcaaa agccgccact
    12781 tcctcatgcc tcacatgaat ccattcaatg gtcttcctcc tcctcaaagc gtccgtaacg
    12841 gggttcaggc tatcccccac aat
//
