LOCUS       c00005_gnlPro..        16248 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BHFMIGBI_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:15:21
            Original ID  :: gnl|Prokka|BHFMIGBI_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16248
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16248
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3255:6248]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3256..6248
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16248
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16248
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(492..1679)
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MKKKIFILLLCVVLIATCILCGVTGIFGNDSQNSPKPQTPDTAVT
                     ENMTFPSKVDSLTLKVGESKLIELSSEKAKSVTKWTSSDSKIVTVDDGGRVDALKEGTA
                     LISAISKDKSKSEFQVTVAKSTTKKQQSYSTCITANLDKLENNKRNTAKNLYAIKVNRT
                     ANCVTVYTYDEKGKYTIPVRAMICSTGLDNSTITGDYTIGIKSEWLSLVGDVFGRYISG
                     ISGDYLFHSVPYYSMSEEDLELEEFNKLGEQASQGCVRLAVSDAKWVYDNCPTGTNVSI
                     YDDAENAGPLGKPDAIKITDFTNKWDPTDSNKKCPYAKATPIISGANDYTIKSGGEFYA
                     LAGVTAVDTCGNDITSNIEVFGNVVTTRKGKYKVTYSVTDVLKRTSSVTITVTVQ"
     CDS             1856..2380
                     /locus_tag="ctg5_2"
                     /transl_table=11
                     /translation="MAHPIKHFRTITRHRHKVIANCARAGILRQGLIHDLSKYSPTEFI
                     PGAKYFQGTRSPNEKERELYGYSQAWLHHKGRNRHHYEYWNDYNPKTKQIENVEMPVKY
                     VIEMFCDRVAASKIYNGKNYTDGAPFTYFCRIRGKHRMHPNTEALLEKLLVMLRDEGEE
                     KTFAYIRSMKK"
     CDS             2498..2989
                     /locus_tag="ctg5_3"
                     /transl_table=11
                     /translation="MKTDRVITAMIEYFGSDKKRIHHFLKVYSFAKTIGESENLLPDDQ
                     ELLEISAIVHDIGIKVSEEKYNSSAGKYQELEGPHEAEKLLAALGYEKTFIDKVCYLVG
                     HHHTYGNIDTLPYRILVESDFLVNLYEDDSSRSAAEQAYDKIFRTNTGKNLLKIMFLIP
                     "
     CDS             3256..5493
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_4"
                     /sec_met_domain="Gly_radical (E-value: 5.5e-41, bitscore:
                     131.3, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 1.6e-271, bitscore:
                     893.7, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREEWTNFAGGKWESDIDVRDFIQRNYTPYDGDQSFLEGPTEATD
                     KLWGELKELQKEERAKGGVLDMETEVVSGITAYGAAYLDKDLEKVVGLQTDKPLKRAFM
                     PYGGIKMAEQSCQMYGYTPSPKLHEIFTKYHKTHNQGVFDIYTPEMKLARHNKILTGLP
                     DTYGRGRIVGDYRRVALYGIDRLIEGKKEDFAETNRQGMRRGDFQLREEIADQIRALND
                     MKEMALSYGFDISQPAKNAAEAVQWLYFGYLAAIKTQNGAAMSVGRVSTFLDIYIERDL
                     ENGTLTESQAQELVDHFVMKCRMVKFARIESYNQLFSGDPVWATLEVAGLGIDGRSMVT
                     KNDYRFLHTLENMGPSPEPNLTVLYSSRLPENFKKYAAHISVTTSSIQYENDDVMRPVW
                     GDDYSICCCVSATQTGKEIQFFGARANLAKCLLYAINGGIDEKTKMQVGPEYTPITSEY
                     LDYDEVIKKYDTMMDWLAHLYVGTLNMIHYMHDKYYYEAAEMALIDTDVRRTFATGIAG
                     FSHVVDSLSAIKYAKVKVIRDEDGIAVDFETEGDFPRYGNNDERADKIAVDLLKTFMAK
                     LKYCHTYRDSEPTTSILTITSNVVYGKATGSLPDGRKAGEPLSPGANPSYGAEQNGLLA
                     SLNSVAKLPYEYALDGISNTQTINPGALGHNDDERVDNLVNVMDGYFDQGAHHLNVNVF
                     GTEKLIDAMEHPEKEEYANFTIRVSGYAVKFIDLTREQQLDVIARTCHDRM"
     CDS             5493..6248
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 76.2;
                     E-value: 1e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_5"
                     /sec_met_domain="Radical_SAM (E-value: 3.8e-30, bitscore:
                     97.2, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDNAVKGFVHSIETFGSVDGPGVRFVIFLSGCAMRCQFCHNPDT
                     WKHDENTVEYTADELLNKALAYRPYWKNKGGITVSGGEPLLQIDFLLDLFKKAKKQGVN
                     TCIDTSANPFTTKEPFYSKWKELMEYTDLLLLDIKHIDNEQHKILTGQPNTNILEMARQ
                     LSDMGKPVWIRHVLVPERNDKDEYLFRLADFIRSLKNVERVEVLPYHTLGVYKWKALGY
                     DYPLEGIEPPTKERVKNAEMILNGEKTRD"
     CDS             6793..7011
                     /locus_tag="ctg5_6"
                     /transl_table=11
                     /translation="MDKNKKLFYTIIGAISALAAATAAFLALKKHRCAEQKLIEEIDDI
                     VSEKEPEEAAKEEPQAEVTADELAEEE"
     CDS             complement(7323..8474)
                     /locus_tag="ctg5_7"
                     /transl_table=11
                     /translation="METLIIGKPKIEKLDNRARLCSKISENGKPSYTLWFDVDAKYADY
                     LTESADAFVVALLPYAMNNSLNISAEAKMSKQLCFQLNEIFIPVLTKNSKLFNKISISA
                     KELTQENYCCKNASATGFSRGVDSFDTICSLSENSMEKLSHLTFFNVGSHRSTANYTPE
                     QSAELYENRLEIAKKSAKIFDMPLIDINSNLGEHLTLPYVKVHHYCSFSAVLCMQKFFK
                     NYYYASGYPISSFSIKQCDTGSAHYEAFTASMLSTESTDFYITGLEKTRLEKVDFISKF
                     PITYDNLNVCYYGENNCGHCEKCVRTQFELMALGKLELYKNVFDIPKFYRDKNKYMDYV
                     LKHQNKDYYAEILSLMKKKGFKLTPIQKIKKAVYAIYLKFRGN"
     CDS             complement(8490..9674)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) UDPG_MGDP_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) UDPG_MGDP_dh"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_8"
                     /sec_met_domain="UDPG_MGDP_dh_N (E-value: 3.1e-37,
                     bitscore: 119.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="UDPG_MGDP_dh (E-value: 9.1e-29, bitscore:
                     91.4, seeds: 679, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAIAGTGYVGLSNAVLLSQKHEVTAVDVVESKVKLINEKKSPI
                     ADREIEEYLADKKLNLVATVDAKSAYKNADFVIISTPTNYDDERHFFDTSSVEAVIKLV
                     IECNPNAVIVIKSTIPVGYTKSVIEKYKYTKILFSPEFLREGKALYDNLYPSRIIVGVD
                     MANEELKKSAETFATALADCAIKENIDTLFMDYTEAEAVKLFANTYLAMRVSFFNELDT
                     YAEMKNLNTKSIIDGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLKANFSDVPNDIISA
                     VVTSNKTRKEFITSQIMNKNPKAVGIYRLTMKSNSDNFRQSSIQSVMELLKNNGIELII
                     YEPTLKVDLFEGFSVENDFEKFVTKSDVIVANRYSSVLDCVKEKVYTRDLFFRD"
     CDS             complement(9689..11452)
                     /locus_tag="ctg5_9"
                     /transl_table=11
                     /translation="MYSTIKSIQLLTALLKKYNINKLVLSPGGSDIPIIHSLENDDFFE
                     CHSVVDERSAVYYGIGLAQQTKSPVACICTSGTAVSNYLPGMTEAFYQDVPIVAITADK
                     DPYRLNQLMLQKTQQVNIFESVTKKSVNLPVVRGGNDRWYCERLINEALSELDHHGTGP
                     VHINIPIVENSAVYDCENLPQVRKINRISPDMPSEKWREYAERLSKYKKILVIAGQNNC
                     FSEDDRACVEKFFEKYNCLISVEHMSNLKCKGCLMTYPLSECSMQGMFGELCPDLIISF
                     GNNIASYKLKPMIKAHKEKFVHWQIDTAGRIRDFSDKLTDVFECTPQYFFNCFAENAPQ
                     NSKNDMTYYNMWNDDIKMLDYSSNLPFSNMYVAKKLAEIIPDRSVLHLAILSSTRTMQF
                     FDLKPNVKVYSNIGALGIDGCMSSFFGQASATDELAFCVVGDLSFFYDMNSAGIRGIKN
                     NARIILLNNGGGSEFHFFMGKEKIPTINQYICAEHHKGAKGWIESLGYDYYSATTKEEV
                     DNIIPTLAEESDRPIFVEIFTDMEEDAKLINRLFHDNRMKFGGMKLKMMEKAKSILSPS
                     QIQKAKKLLKK"
     CDS             complement(11628..12707)
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MKKVGIVTFHRALNYGAVLQSYALQKTVSSLGAECEIVDYICPKI
                     TADYKPFRIYKNDLLKSFAKSCVMVRRRAKRRDAFKSFFNNYLVKSKKSYTPQNIRELK
                     NDYDLFISGSDQVWSPRCVGFDPAYFLTFADDKQKYSYAASFAVPTLPDEFIDEYKKRL
                     NGFQKFSVREPSGEKLVKELTGRTAETHLDPTLLISADEWKKIAVSKIDKPYILIFTAN
                     PAVSLVDFAIKLSKEKNLPVYCINDAPHPVSHGINYIVAPTVEEFVGCFKNAEYVVTNS
                     FHGTAFSVIFNKNLFVEFKNKSGRNIRSEGLLKSLGINREIVDGNCRETEINWYDVNEK
                     IKNQTIISLDYLKSFVSGG"
     CDS             complement(12707..13621)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.8e-30,
                     bitscore: 97.8, seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEYTFSVFTPSYNRAKTLPRLYEALKKQTYRNFEWIIVDDGSAD
                     NTKETVEKFISDRPDFNITYKYQTNKGKHIATNVAAQIAKGEFFITIDSDDSVKDDALE
                     TFINEWNKIPDEDRSKYKGISCRTCNESGKTNGCPLPSERFDCSDLDLRLKYKIDGEMW
                     GMTKLEIIRANPYPCVSGLHFYPENIYWDNIGRKYITRFIDTPLRYYINDQENSLTGNA
                     YSAHRETIFVRLHFINECWDYAKSNPKFFIKQFVGLSRDGLLNGKRFSEIKKMPDTFSK
                     RALAVIFYPMGYFLYKKQSGGSR"
     CDS             complement(13645..15189)
                     /locus_tag="ctg5_12"
                     /transl_table=11
                     /translation="MKKLSTSKQMAINMVAAIVSFLIGTGINFVLAPYLVKELGSETYG
                     FIGLANNFVQYATIVTSALNSMSGRFISIEYSKGNIDKASRYFSSVLVADLIIAGVLLL
                     VSSIITFNIEFILNVPENLVDSVKILFALTFATFIISVITAIFTTAAFVKNKLYINSLR
                     DIASNTLKLLLVVILFSFFPAKVYFLAMASLASGIFLLLTNIKVKNKILPEVKMNFNLF
                     SFKLVKVLISAGIWSSIGYLSTALNRGLDLLICNLTLGAGLMGLLSIANTVPHCIDNLI
                     TTIANIFTPRFTILYAKDNTDLLVEETKFSSKIMSFLMTAPLAGFIAFGNKFYTLWQPT
                     KSPDEITIIQILSVLVCISYLFTCHTRTLSSLFTVCNKLKASVLISLVCGVLTVIIVLL
                     LIHFTPLGVYAIAGVSSVFIGLKAIVFVPLYAAHILKIKLTTYYRSIFRGWFCFAVVIT
                     MFIFINSFVHANSWMSFLLLCAASGLAGYAVSVPLIFSRKELVLIKDKIKKKFKKS"
     CDS             complement(15213..16037)
                     /locus_tag="ctg5_13"
                     /transl_table=11
                     /translation="MVYKIMYPPIPNMGDLLNKDMLEELFNIKVVRKDLKSCNLIAIGS
                     ALDHIMYSTYPRIRAKQKIEHFMNDNVHIWSTGFIRGNAELDLGLMFRHIHIHALRGRL
                     SLQRMENILGKKLDVPTGDGGLLAERWLGFYPEKKYRVGIIPHFKEQDHPVVKKLLDNY
                     ENSTLIDLKENPKKVVEKIGECEYIISSSLHGMIVADSFHIPNMHITLTNNMFGDGNKY
                     NDYLSAFDITHTPFDCSNGDMPTISEVKNNYRIDPDVVELKKEQLFNAFPKF"
ORIGIN
        1 taaaactgta tactatgtct ttgcactgtt gtattctatg ttactacact gcacacatcg
       61 gccgcccgcc ttgatgaaat attttgttta atcatatatg ttttgatgtg attataattg
      121 tgtattgaac cttgcacgca ttgcgtgcaa tcgtatgcgt tgcatacgaa cgggcgaaca
      181 cggttccccc taaaacatac attgcaaaaa taattggaat gttatacttg gtcaaaatat
      241 gtatgttgct gtgtggttga tttggctttg caaccaaatc aaatggcggt cactgaccgc
      301 cgctactgta tgtacaaaca attgctatgt tatgctcggg caacatttgt aatttactat
      361 taaaaccgtc tgcacgaaca cacgaacata aaaaatgcgg tggcacattg ccaaccgcat
      421 ttttatttta cattttcaat tttccacttt caatttaaaa gctccgctcg gagaacagtg
      481 gcgcaccatg tttattgcac cgttaccgta atcgttacgc ttgatgttct tttaagcaca
      541 tcggtgactg aatatgttac cttgtacttg ccttttcggg tggttactac attgccgaaa
      601 acttcgatat tcgatgttat gtcgttgccg caggtgtcaa cggctgttac tcctgcaagg
      661 gcgtaaaatt cgccgccgct tttgattgtg taatcgtttg caccgctgat tattggtgtt
      721 gctttggcat acgggcattt tttattgctg tctgtcggat cccatttgtt ggtaaaatcg
      781 gtgattttga ttgcatccgg ttttccgaga gggcctgcat tttctgcgtc gtcatatatg
      841 cttacatttg tgcctgtggg gcagttgtca taaacccact ttgcatccga aaccgcaagt
      901 cttacgcatc cttgtgacgc ctgttcgcca agcttgttga actcctcaag ctccaaatct
      961 tcttcgctca ttgagtagta gggaacggag tggaaaagat aatcgccaga aattccgctg
     1021 atgtatcttc cgaaaacatc gcccacaagg gaaagccatt cggacttgat tccgattgtg
     1081 tagtcacccg tgattgtcga attgtcaaga cctgtggagc aaatcatcgc ccttacgggg
     1141 attgtgtact tgcccttttc gtcatatgtg taaaccgtca cgcagtttgc cgtgcggttg
     1201 accttgattg cgtacaggtt ttttgccgtg ttacgcttat tgttttcaag cttgtcaaga
     1261 tttgccgtta tacaggttga gtagctttgc tgttttttcg tggttgattt tgccaccgta
     1321 acctgaaatt ccgactttga tttgtctttt gaaatggcag aaatcagagc cgtaccctct
     1381 ttgagagcgt caacccttcc accgtcatca acggtaacaa ttttactgtc cgagcttgtc
     1441 catttggtaa cggattttgc tttttcggat gacagttcaa taagctttga ttcgccgact
     1501 tttaatgtga gcgaatcgac cttgctcgga aatgtcatat tttcggttac tgccgtatcg
     1561 ggcgtctgcg gttttggaga attttgagaa tcatttccga aaattcccgt cacaccgcat
     1621 aatatgcagg ttgcaatgag gacaacacaa agtaaaagaa tgaaaatttt ctttttcata
     1681 gattacctat ccttatagaa tttaacatta aatggttaca aaattttaac ctttgtatat
     1741 tataactttt tttcgacaat cttgcaagtg ctattttaaa tcggcgagaa atgtggtaaa
     1801 atgtcagtcg gagaatgttt tgtattttcc aaactaacaa tttatggtga taattatggc
     1861 acatccgatt aaacatttca gaacaataac ccgtcacagg cacaaggtaa ttgccaactg
     1921 tgcaagggca ggaattctca gacagggatt aatacacgat ttgtcaaagt attcgcctac
     1981 agaatttatt ccgggtgcaa agtattttca gggcacgaga agtcccaatg aaaaggaaag
     2041 agagctgtac ggctattcac aggcgtggct gcatcacaag ggcagaaacc gtcaccatta
     2101 cgaatactgg aacgattaca acccaaagac aaagcagatt gaaaatgttg aaatgcctgt
     2161 aaaatatgtt atcgaaatgt tctgcgaccg agttgccgca agcaaaatct acaacggcaa
     2221 aaattacacg gacggcgctc cgtttacata tttttgcaga atcagaggca aacaccgtat
     2281 gcaccccaac accgaggctt tgcttgaaaa attattggtt atgctgagag atgagggtga
     2341 agaaaagacc tttgcatata taagaagtat gaaaaagtga ttgtttgtgc gaatcctccc
     2401 gtctgaaata tagtcgcaag gctaccccta cagaattgca caaacaaaaa ctatctacac
     2461 gaatagggta cggcggctcg ccgtaaggag tgataatatg aaaaccgaca gggttataac
     2521 tgctatgatt gaatattttg gaagtgacaa gaaaaggatt caccattttc tcaaggttta
     2581 ttcattcgca aagacaatcg gtgaaagtga aaatcttttg cccgacgatc aggagcttct
     2641 tgaaatctcc gcaatcgttc acgacatcgg cataaaggtg agcgaagaaa agtacaattc
     2701 gtctgcagga aagtatcagg aacttgaagg tcctcacgag gctgaaaagt tgcttgccgc
     2761 tctcggttac gaaaaaacat ttattgacaa agtttgttac cttgtgggac accatcacac
     2821 ctatggaaat attgatactt tgccgtaccg aattttggta gagtcagact tccttgtgaa
     2881 cctttatgag gacgattcaa gccgcagtgc agcagagcag gcatatgaca aaatattccg
     2941 cacaaataca ggaaaaaatc tgctgaaaat aatgttcctc ataccctaaa attgtactca
     3001 tttaccatag tgttttgagc gtgaaaaagt ggtgtaaaaa gtatcccaaa atgcttgaca
     3061 acgcccttaa aaagtgttat tttaatggtg ttggttatat gattataaaa gtgaataaat
     3121 gacagaatac aaggatgtat gacgattttt tcaaggagct gaccttaccg ggcgtctgct
     3181 tggaattgag tcggcatttt tttgtgtcat atacaaaatt cagtattaat tatcattatc
     3241 ggaggtttta cagtaatgag agaagaatgg acaaattttg caggtggcaa atgggagtcc
     3301 gacattgatg tcagagactt cattcagaga aactacacac cttatgacgg cgaccagtct
     3361 ttccttgaag gtcctacaga agctacagac aagctctggg gcgagctcaa ggaactccag
     3421 aaggaagaaa gagccaaggg cggcgttctt gatatggaaa ctgaggttgt aagcggcatc
     3481 acagcttacg gcgctgcata tcttgataaa gaccttgaaa aggttgtagg tcttcagaca
     3541 gacaagcctc tcaagcgtgc atttatgcct tacggcggta tcaaaatggc tgagcagtca
     3601 tgccagatgt atggctacac tccaagccct aaactccacg aaatctttac aaaatatcac
     3661 aagactcaca accagggtgt attcgatatc tacactcccg agatgaagct tgcccgtcac
     3721 aacaagattc ttacaggtct tcccgacaca tacggcagag gcagaatcgt cggtgactac
     3781 agaagagttg ctctttacgg tattgaccgt cttatcgaag gcaagaaaga ggactttgca
     3841 gaaacaaacc gtcagggtat gagaagaggc gacttccagc ttcgtgaaga aatcgctgat
     3901 cagattcgtg ctcttaacga tatgaaggaa atggcacttt cttacggctt tgatatttca
     3961 cagcctgcta agaatgccgc agaagcagtt cagtggctct atttcggcta tcttgctgct
     4021 atcaagactc agaacggcgc tgcaatgagc gttggtcgtg tatcaacatt cctcgacatc
     4081 tacatcgagc gtgaccttga gaacggtaca cttacagaat cacaggctca ggaacttgtt
     4141 gaccactttg ttatgaagtg ccgtatggtt aagtttgcaa gaattgagtc ttacaaccag
     4201 ctcttctcgg gcgaccctgt atgggctaca ctcgaagttg caggtcttgg cattgacggc
     4261 cgttcaatgg ttacaaagaa cgactaccgt ttcctccaca cacttgagaa tatgggacct
     4321 tcacctgagc caaacctcac agttctttat tcttcaagac ttccggagaa cttcaagaag
     4381 tatgctgctc atatttcagt tacaacaagc tcaattcagt acgagaatga tgatgtaatg
     4441 cgtcctgtat ggggcgatga ttactcaatc tgctgctgcg tatccgcaac acagacaggt
     4501 aaggaaatcc agttcttcgg cgcaagagct aaccttgcta agtgccttct ctacgctatc
     4561 aacggcggta ttgatgaaaa gacaaagatg caggttggtc ctgaatatac acctatcaca
     4621 tcagagtacc ttgattatga cgaagttatc aagaagtatg acacaatgat ggattggctt
     4681 gctcacctct atgtaggcac acttaacatg attcactaca tgcatgataa gtactactat
     4741 gaggcagcag aaatggctct tatcgataca gatgtaagaa gaacatttgc aacaggtatt
     4801 gcaggcttct cacatgttgt tgactcactc agcgctatta agtacgctaa ggttaaggtt
     4861 atccgtgacg aggacggcat tgctgttgac tttgaaacag agggcgactt cccaagatac
     4921 ggtaacaatg acgagagagc agataagatt gccgttgatc ttctcaagac attcatggct
     4981 aagctcaagt attgccacac atacagagat tcagagccta caacttctat ccttacaatc
     5041 acatcaaatg ttgtttacgg taaggctaca ggttcacttc ctgacggcag aaaagcaggc
     5101 gaaccacttt cacctggtgc taacccaagc tacggtgcag agcagaacgg tcttcttgct
     5161 tcacttaact ctgttgctaa gcttccttac gagtacgctc ttgacggtat ttcaaatact
     5221 cagacaatca acccgggtgc tctcggacac aacgatgacg agcgtgttga caacctcgta
     5281 aatgttatgg acggctactt tgatcagggc gcacaccacc tcaatgtaaa tgtattcggt
     5341 acagaaaaac tcattgacgc tatggagcat cctgagaagg aagagtatgc taacttcaca
     5401 atccgtgtat cgggttatgc tgttaagttc atcgacctta caagagagca gcagctggat
     5461 gttattgcca gaacctgcca cgacagaatg tgatgtcgga caacgctgtt aaaggctttg
     5521 tacactcaat agaaactttt ggctctgttg acggtccggg tgtgagattt gtgatttttc
     5581 tgagcggttg cgcaatgcgt tgccagttct gccacaatcc cgacacctgg aaacacgatg
     5641 aaaacaccgt ggaatatacc gccgacgagt tgcttaataa agcgcttgca taccgcccct
     5701 attggaaaaa taagggcggt atcacagtaa gcggaggtga gccgctttta cagattgact
     5761 ttttgcttga tttgttcaag aaggctaaaa agcagggcgt taatacctgt attgacacaa
     5821 gcgccaaccc gtttacaacc aaagagccgt tctattcaaa gtggaaagag ctaatggaat
     5881 atacggattt gctgttgctt gatataaagc atatcgacaa cgaacagcac aaaatcctta
     5941 caggacagcc aaacaccaat attcttgaaa tggcaagaca gctttccgat atgggcaagc
     6001 ccgtatggat aagacatgtt cttgtgcctg aaagaaatga taaggacgag tatcttttca
     6061 gacttgccga ctttatccgt tcgctcaaga atgttgagcg tgtagaggtg cttccgtatc
     6121 acacactcgg tgtgtacaag tggaaggctc tcggttatga ctatcctctc gagggcattg
     6181 agcccccgac aaaagagcgt gttaagaatg cggaaatgat tcttaacggc gaaaaaacaa
     6241 gagattaatt tcttatataa caacggcagt accgattttt tggtactgcc gtttttgttt
     6301 tgatttttat ttgttattct gcttttgttg ttttttcttc agcaaaattg atgaatcaaa
     6361 ggtgtattca aagattttta agccgtcctt gttgagaaat cgtcaccgtc ggaagaatcg
     6421 accgctactc aggaacagac tgttcagact gctccgacgg gtgagcctgc aactgtcggt
     6481 acaatctctg caaatccgac ttcggcaaca ggcagtgccg caacatcgga cagcactcct
     6541 tcacagcctg ataaaaacgg cagtgttcag acaggagtga cagcaacggc tgttatgatg
     6601 cttgttgtaa tttcgggcgg agtgcttttt gcccttgcag agcgtaaaaa gagaatataa
     6661 cacactgaca gccatttgtg caaagattat cagttgccta ttgaaaaatt tgtaaaaatg
     6721 atataaaata gcaataagta gaaaaatacg gtttttccgc tgatttatat taatactgaa
     6781 agaggtgccg gaatggataa aaacaaaaaa ttattctaca caatcatcgg tgcaatctct
     6841 gcacttgcgg ctgccacagc agcatttctc gctttaaaaa agcacagatg cgcagaacag
     6901 aagcttattg aggaaattga cgatattgtt tccgaaaaag agcctgagga ggctgcaaag
     6961 gaagaaccgc aggcagaagt tacagccgat gagcttgctg aggaagaata agcaacaagt
     7021 tgttgcaccc aattcgggta gcagtatttg catatgcaaa agttaaatac ccgagcggtg
     7081 ctttcaatta agaattgaaa gttgaaaaca gataatgatg tcggcggtgt gccaccgcag
     7141 tctattcaag aaaacagttt aaaaaagaaa aatgcatcag ttgcccgaaa agctctgatg
     7201 catttttgtt ttgtgcgaag taaccgccaa acccacagcc gtgaggcatt ataaaaacgc
     7261 agacatcatc tgatatctgc tatacctcct caatggcttg tcggttaaag caaccgtaag
     7321 ccttaattcc ctctgaattt aagataaatg gcatagacag cctttttaat tttttgaatt
     7381 ggcgtaagct tgaaaccctt ctttttcata agactgagaa tttctgcata atagtccttg
     7441 ttctgatgtt tgagaacata gtccatatat ttgttcttgt ctctgtaaaa tttcggaata
     7501 tcaaaaacat tcttatacag ttcaagtttt ccgagtgcca taagctcaaa ttgcgttctg
     7561 acgcactttt cacagtgacc gcagttgttc tcaccgtagt aacacacatt gaggttatca
     7621 tatgtaatcg gaaattttga aatgaagtca accttttcaa gcctagtctt ttcaagccct
     7681 gtaatgtaaa aatcggtact ttcggtactc agcatacttg ccgtaaatgc ctcatagtgt
     7741 gccgagccgg tgtcgcattg ttttatcgaa aaactgctta tcgggtatcc cgacgcatag
     7801 taatagtttt tgaaaaattt ctgcatacat aagaccgccg aaaagctgca ataatgatga
     7861 acctttacat acggcagggt aagatgttca ccgagatttg aattaatgtc aatcaacggc
     7921 atatcaaaga tttttgcgga tttttttgca atttcaagac gattttcgta cagctcggca
     7981 gattgttcgg gtgtgtaatt agccgtactc ctgtgggagc cgacattgaa aaaggtaaga
     8041 tgactcagct tttccatgct gttttcggaa agactgcaaa ttgtgtcaaa tgaatccaca
     8101 cctctcgaaa atcctgttgc cgatgcattt ttgcagcagt agttttcctg tgtaagctct
     8161 tttgcagata tcgaaatttt gttgaataat tttgaatttt ttgtaagaac gggaatgaaa
     8221 atttcattaa gctgaaaaca cagttgcttc gacatctttg cttctgccga aatattcaga
     8281 ctgttgttca ttgcatacgg caacagcgca acaacgaatg cgtcggcact ttcggtcaga
     8341 tagtcagcat actttgcatc aacatcaaac cagagagtgt aggaaggctt tccgttttcg
     8401 ctgatttttg aacagagtct ggcacgatta tcaagttttt caattttcgg tttgccgata
     8461 atcaatgttt ccatactttt accctcaaat taatctctga aaaacaaatc tcttgtgtaa
     8521 accttttctt ttacacagtc aaggacggag ctgtatctgt ttgcaacgat tacatccgat
     8581 tttgtgacga acttttcaaa gtcgttttca acgctaaagc cctcgaataa atcgacttta
     8641 agtgtcggtt cgtagataat taactcgata ccgttatttt tcaaaagctc cataacgctc
     8701 tgaattgagc tttgtctgaa gttatcggaa tttgacttca ttgtaaggcg gtaaattccg
     8761 acagcttttg gatttttatt cattatctgt gatgtaataa attcttttct tgtcttgtta
     8821 gatgttacaa cagcgctgat tatgtcgttc ggaacatccg aaaaattggc cttgagctgt
     8881 tttgtgtcct ttggcagaca gtaaccgccg tagccaaagg acggattgtt gtagtgattt
     8941 ccgattctcg gatcaagaca cacaccgtca atgatacttt tagtgttaag gttcttcatt
     9001 tcggcatatg tgtcaagctc gttgaaaaag ctgacacgca ttgcaaggta tgtatttgca
     9061 aaaagcttta ccgcttctgc ctctgtgtag tccataaaga gagtgtctat gttttcctta
     9121 attgcacagt ctgcaagtgc cgttgcaaaa gtctcggcag attttttcag ttcttcattt
     9181 gccatatcaa caccgacaat gattcttgac ggatagaggt tatcatagag agccttgccc
     9241 tcacgcaaaa attcgggact gaaaaggatt tttgtgtatt tgtatttttc aataacactt
     9301 tttgtgtatc caaccggtat agtggatttg ataactataa ccgcatttgg gttgcattca
     9361 attacaagct taattacagc ctcaacggac gatgtatcaa aaaagtgtct ttcgtcatcg
     9421 taattggtag gagtagagat aattacaaaa tcagcatttt tgtacgcaga ttttgcatcg
     9481 acggttgcaa ccaaatttaa ttttttgtca gcaagatatt cttcgatttc cctgtcggca
     9541 atcggagatt tcttttcatt gattaacttt accttgcttt caactacatc aacagcggtt
     9601 acctcgtgtt tctgcgaaag aagtacagcg tttgaaagac ccacataccc tgtcccggca
     9661 attgctattt tcatttggtt tcacctgatt acttttttaa taattttttt gccttttgaa
     9721 tctgtgacgg actgagaatt gactttgctt tttccatcat cttgagcttc attccgccaa
     9781 atttcattct gttgtcatga aaaagcctgt taataagctt tgcgtcctct tccatatcgg
     9841 tgaaaatctc aacaaaaatc ggtcggtcgg attcttctgc gagtgtggga ataatgttgt
     9901 caacttcttc cttggttgtt gcgctgtaat agtcatatcc gagtgattca atccagccct
     9961 ttgcgccctt gtgatgttcg gcgcagatgt actgattgat tgtaggaatc ttttccttgc
    10021 ccataaagaa gtgaaattct gaaccgccgc cgttgttgag aagaataatt ctcgcattgt
    10081 tcttgattcc tctgatgcct gcggagttca tatcatagaa gaaactgagg tcgcccacaa
    10141 cgcaaaaggc aagctcgtct gttgccgatg cctgtccgaa aaacgaagac atacagccgt
    10201 caatacccag agcgccgata ttgctgtaaa ccttgacatt cggtttcaaa tcgaagaact
    10261 gcatagttct tgtactgctg agaattgcaa ggtgcagaac agaacggtcg ggaataattt
    10321 cagcaagctt tttggcaaca tacatatttg agaacggaag attgcttgaa taatcaagca
    10381 ttttgatatc gtcattccac atattgtagt atgtcatatc attttttgaa ttctgcggtg
    10441 cgttctctgc aaagcagtta aagaaatact gcggtgtaca ttcaaataca tctgtcagct
    10501 tgtcggaaaa atctctgatt cttcccgcag tatcaatttg ccagtgaaca aatttttcct
    10561 tgtgagcctt aatcataggc ttgagtttat atgaagcaat attgttgccg aacgaaataa
    10621 taagatcggg gcataactcg ccgaacattc cctgcattga gcattctgac aaaggatagg
    10681 tcataaggca gcccttgcac ttgaggtttg acatatgctc aaccgatata aggcaattgt
    10741 atttctcaaa gaacttctcg acgcacgctc tgtcatcttc cgagaaacag ttgttctgac
    10801 cggcaatgac aagaattttc ttatattttg aaagcctttc tgcatattca cgccacttct
    10861 cggagggcat atcgggagaa attctgttga ttttcctaac ctgaggaaga ttttcacaat
    10921 catatacagc cgagttttca acaatcggaa tattgatatg cacaggtcct gttccgtgat
    10981 ggtcaagctc cgaaagagcc tcgttaataa gtctttcgca gtaccatctg tcatttccgc
    11041 cacgcacaac gggaagatta acggattttt ttgtaaccga ttcaaaaata ttgacctgct
    11101 gggttttctg cagcataagc tgatttaatc tgtacgggtc tttgtcagcg gtaattgcga
    11161 caatcggaac atcctgataa aatgcctctg tcatacccgg aagatagttg cttacagccg
    11221 tacccgaggt acagatacag gcaacggggg attttgtctg ctgtgcaagt ccgatgccgt
    11281 aatacacggc acttctctcg tcaacgaccg aatgacactc aaaaaaatcg tcattttcaa
    11341 gtgaatgaat tataggaata tcactgcctc cgggagaaag caccaatttg ttgatattat
    11401 attttttcag aagtgcagtg agcaactgaa tgctttttat tgtagaatac atacgctttc
    11461 ctccgcttta gtttttgata attccggaac cgcctgtaat cagagcggtt ttgccgtcaa
    11521 gaatattgtt gttctccttc tgcacataca cgggaacaac attttttgct ttaaaggttt
    11581 tgattatgcc ctgtctgact ttttttagtg tatttttaag actcatttta accaccgctg
    11641 acaaaggatt taagataatc caaagatatt attgtctggt tcttgatttt ttcgttcaca
    11701 tcgtaccagt ttatttcggt ttctcggcag tttccgtcaa caatttcacg gttgattcca
    11761 agacttttca aaagaccttc ggagcggatg tttcttccgc ttttgttctt gaattcaaca
    11821 aaaagattct tgttgaaaat aacagaaaac gctgttccgt gaaacgagtt tgtaacaaca
    11881 tattcggcat ttttgaaaca gccgacaaat tcctcaacag taggtgcaac aatataattt
    11941 ataccgtgac ttacagggtg aggtgcatcg tttatgcagt aaacgggaag gttcttttct
    12001 tttgacagtt taatggcaaa atccacaagc gaaactgccg gattagccgt aaaaatgagg
    12061 atatacggtt tgtcaatttt tgaaacggca atctttttcc attcgtctgc cgaaatcagc
    12121 agggtaggat caagatgagt ttcggcggtt ctgcccgtga gttcttttac aagcttttct
    12181 ccgctcggtt cacgaactga gaacttctga aaaccgttca gccttttttt atattcatca
    12241 ataaattcat cgggcaatgt cggaacggca aagcttgccg catatgaata cttctgtttg
    12301 tcatcggcaa atgtcagaaa ataagcggga tcaaaaccga cgcatctcgg actccatacc
    12361 tgatcgcttc ccgaaatgaa caagtcataa tcgtttttaa gctctctgat attttgcgga
    12421 gtatacgact ttttactctt tacaagatag ttattgaaaa acgacttaaa agcgtctctg
    12481 cgttttgctc ttcttcttac catgacacag ctttttgcaa aggatttcag aaggtcgttt
    12541 ttataaatgc gaaagggttt gtagtcggct gtgattttcg gacagatata gtcaacaatt
    12601 tcacactccg caccgagcga tgaaacggtt ttttgcaacg catagctctg aagcacagcg
    12661 ccgtagttca atgcacggtg aaatgttaca atgcctacct ttttcattat ctgcttcccc
    12721 ctgattgttt tttgtacaaa aaatatccca tgggataaaa tatgaccgca agagccctct
    12781 ttgaaaatgt gtcgggcatc ttttttattt cggaaaatct tttaccgttg agtaagccgt
    12841 cacgggaaag tcccacaaat tgtttgataa agaacttagg attgctcttt gcgtaatccc
    12901 aacattcgtt tataaagtgg agtcttacga aaatagtttc cctgtgagcc gagtaagcgt
    12961 tacccgtcaa agaattttcc tgatcgttta tgtaatatcg caacggtgtg tcaataaaac
    13021 gggttatata ttttcttccg atattgtccc aatagatatt ttcgggataa aaatgaagtc
    13081 ccgaaacaca cggataaggg ttggctctga ttatttcaag ttttgtcatt ccccacatct
    13141 caccgtcaat tttatacttc aatctcaggt caaggtcgga acagtcaaat cgttctgacg
    13201 gcagaggaca accgtttgtt ttgccgcttt cgttacaggt gcggcacgaa attcccttgt
    13261 attttgatct gtcttcatcg ggaattttgt tccattcgtt tataaatgtt tcaagggcat
    13321 cgtcttttac gctgtcatcg gagtcaatcg ttataaagaa ttcacccttt gcaatctgtg
    13381 ccgcaacatt tgttgcaatg tgttttcctt tgttggtctg atatttatag gttatgttaa
    13441 agtcaggtct gtcgctgatg aatttctcaa ccgtttcttt tgtgttgtcg gctgaaccgt
    13501 catcaacaat tatccattca aaatttctgt atgtctgttt tttcagcgcc tcatataatc
    13561 tgggcagagt ttttgccctg ttatatgacg gtgtaaaaac ggaaaaagta tattcagtca
    13621 ttgcaacctc aaaatgataa taatttagct tttcttaaac ttcttcttaa ttttatcctt
    13681 gataagaacg agttcttttc ttgagaaaat gagcggaacg gaaacggcat atcctgccag
    13741 tccgcttgct gcacagagaa gaaggaatga catccagctg tttgcgtgta caaagctgtt
    13801 gataaagatg aacatggtga taacaacagc aaagcagaac catcccctga aaatagacct
    13861 gtaatatgtt gtaagcttta ttttcaaaat atgtgcggcg tacaacggaa caaatactat
    13921 cgctttaaga ccgataaaaa cagagctgac gcctgcaata gcataaacac cgagcggtgt
    13981 aaagtgtatg agcagtaaaa cgataataac cgtaagaaca ccgcacacaa gcgagataag
    14041 aacggaggcc ttgagcttgt tgcatacggt gaaaaggcta gaaagagttc ttgtgtgaca
    14101 ggtaaatagg tatgaaatac atacaagcac cgacaaaatc tgaattatgg taatttcgtc
    14161 cggagatttg gtcggctgcc acaatgtata gaacttgttg ccaaacgcaa taaatcccgc
    14221 aagaggtgca gtcatgagaa aactcataat ctttgacgaa aactttgttt cttcaacaag
    14281 taagtccgtg ttgtcctttg cataaaggat tgtaaatctg ggagtgaata tatttgcaat
    14341 ggttgtaata aggttatcaa tgcagtgcgg aacggtgttt gcaatcgaca aaagtcccat
    14401 gagtcccgct ccgagagtca ggttacagat taacaggtca agacctctgt tcagagctgt
    14461 gctgagataa ccgattgacg accaaattcc tgcggaaatc agaactttta ccagcttgaa
    14521 actgaaaagg ttgaagttca tctttacttc cggcagaatt ttattcttga ctttgatatt
    14581 ggtaagcaaa agaaaaattc cgcttgcaag tgacgccata gcgagaaaat atacttttgc
    14641 gggaaaaaac gagaacaaaa ttactacaag caagagcttg agcgtatttg acgcaatatc
    14701 acggagggaa ttgatataca gcttgttttt tacaaatgcc gcagtagtaa atattgccgt
    14761 gataacgctg attataaatg ttgcaaaagt gagcgcaaac aatatcttta cgctgtcaac
    14821 aagattttcg ggaacattca gtataaattc aatgttgaat gtaataattg acgaaaccaa
    14881 aagtaaaacg ccggcaataa tcaggtcggc aaccagaacc gagctgaaat atcttgatgc
    14941 cttgtcaatg tttcctttgc tgtattcaat tgaaataaat ctgcccgaca ttgagttgag
    15001 agcagatgtt acaatggtgg catactggac aaagttgttt gcaagtccga taaatccgta
    15061 ggtttcagaa ccgagttcct ttacaagata gggtgcaaga acaaagttaa ttcctgttcc
    15121 tatcaagaaa gacactatgg cggcaaccat atttattgcc atttgtttac ttgttgataa
    15181 ttttttcata atatgacctt agttttaact gattaaaatt ttggaaaagc attgaagagc
    15241 tgttctttct tcagttcaac aacatccgga tcgattctgt aattattttt cacctcgctg
    15301 attgtaggca tatcgccgtt tgaacaatca aagggtgtgt gtgtaatgtc aaaggcggag
    15361 aggtaatcat tgtacttgtt tccgtcaccg aacatattgt ttgtaagggt tatgtgcata
    15421 ttgggaatgt ggaaactgtc ggcaacaatc ataccgtgaa ggctgcttga aataatgtat
    15481 tcgcactcgc ctattttttc gacaaccttt tttgggtttt ccttcaggtc aataagcgtt
    15541 gaattttcgt agttatcaag aagttttttc acaacagggt gatcctgttc cttaaagtgc
    15601 gggataattc cgacacgata ctttttttcg ggataaaatc caagccacct ttcggcaaga
    15661 agtcctccgt cacctgtcgg cacatcaagc tttttgccga gaatattttc cattctctgc
    15721 aatgaaagtc tgcccctcag agcgtgtata tgtatatgtc tgaacatcag ccccaaatca
    15781 agctcggcat tgcctcggat aaagcccgta ctccatatgt ggacattatc attcataaaa
    15841 tgctcaattt tctgctttgc tctgatcctc ggatatgttg agtacattat gtggtcaagt
    15901 gcagaaccga ttgcaatcag gttacagctt ttaaggtctt ttcttacaac cttgatgtta
    15961 aacagttctt caagcatatc tttattaaga agatctccca tattcggaat cgggggatac
    16021 attatcttat ataccattgt attttctccg ttgtattatt tgcgccgtga gcagaagctc
    16081 tgattaagag atataaatat cggatttgtc ttgcatatgt atatcagcga ataagtaata
    16141 agcatccata tcgatgttgt tgcccatggt tcggtggaaa tcagaagttt tggaagtgtt
    16201 acgcacacaa gcgtacagca caacgcaaat tctgacttat ctttgatt
//
