LOCUS       c00075_gnlPro..        11317 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KJHFNGNC_75.
ACCESSION   c00075_gnlPro..
VERSION     c00075_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 21:10:50
            Original ID  :: gnl|Prokka|KJHFNGNC_75
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11317
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11317
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:9872]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..9872
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11317
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /kind="single"
                     /product="GR_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11317
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="GR_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..1021)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PFL_acetate2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_1"
                     /sec_met_domain="PFL_acetate2 (E-value: 1.6e-135, bitscore:
                     441.9, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFEQWNGFKGNRWKEKIDVRNFIGMNYTPYDGDASFLEGPTEA
                     TNKLWGKLQALQKEERAKGGVLDMETEVVTSLTAYGPGYIDEETKDLEKVVGLQTDKPL
                     KRAFMPYGGIKMAEQACETYGYKVSDKIKDVFHNYEFKTHNQGVFDIYTPEMKVARHNK
                     ILTGLPDTYGRGRIVGDYRRVALYGIDALIEGKQKDFAACDRQGMRRYDFQLREEIADQ
                     IRALKGMKVMAESYGYDISKPAKDAREAFQWLYFGYLAAIKTQNGAAMSVGRISTFLDI
                     YIERDLQNGTLTEKEAQELVDHMVMKFRMVKFARIPSYNQLFSGDPVWATLEVAGMGQD
                     "
     CDS             complement(1428..3083)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg75_2"
                     /sec_met_domain="HMGL-like (E-value: 1.7e-76, bitscore:
                     246.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNPSKYQRQYFMPPVKCMKWAEKEYVDKAPVWCSVDLRDGNQAL
                     VIPMSLEQKIEFFKLLVKIGFKEIEVGFPAASETEYEFLRTLIEQNLIPQDVTIQVLTQ
                     AREHIIRKTFEAVKGAPKAIVHVYNSTSVAQREQVFKKSKEEILKIAVDGAALLKKLAD
                     ETEGNFQFEYSPESFTGTEPEYALEVCNAVLDVWQPTADNKCIINLPVTVQHSMPHVYA
                     SQVEYMCENLKYRENVIVSLHPHNDRGCGVADSEMGLLAGADRIEGTLFGNGERTGNVD
                     IVTLGMNMYSQGVDPKLDFSDMPHICEIYEECTGMKVGERSPYSGALVFAAFSGSHQDA
                     IAKGMHWRDDKDPDHWNVPYLPIDPTDVGRNYDADVIRINSQSGKGGVGYILETKFGLN
                     LPPKMREAMGYATKAVSDHKHKELHPDEIFNLFKQTFENITEPYSINEVHFQQKDGGIV
                     TKVTSTFRGKTITTEASGNGRLDAVSNALKKAYELKYSLETYQEHALERSSSSKAIAYV
                     GIKKPDGTLAWGAGVDADIIRASIDALVTAINNR"
     CDS             complement(3773..4162)
                     /locus_tag="ctg75_3"
                     /transl_table=11
                     /translation="VEDAELRNILFSIQGSIAGFQNDMSDVKNDIADMRTDIANMKTDI
                     TNMKADITNMKTDITNMKSDIVQLKGSVKTIELKLENEIDRKISALFDARMDELRYRKE
                     NKETREKVFELDMRVDNLEKAIMPA"
     CDS             complement(4287..5528)
                     /locus_tag="ctg75_4"
                     /transl_table=11
                     /translation="MAVFHAFRALRPTPEKAADVAALPYDVVNREEAKSIGDENPLSFL
                     HIDRPEMDLEPETDLYDDRVYEKAKENLDNMEEKGILVQDQKACYYIYELVRKGKTQTG
                     IVGCSSIDDYMNGVVKKHELTREDKEQDRIHHVDSCNANTGPIFLACRYPDSLLTLMNN
                     WKDHHEAAYDFTEEDQITHRVWVIDEDEVISEINKEFAGIDSLYIADGHHRAASAVKVG
                     LKRREQNPGYTGEEEFNYFLSVVFPYDQLCILPYNRIVKDLNGLTVKAFLGALKFNFEL
                     MLMPGFPCKPVEKHCMGMYVDGQWYHLKAWPDIYEKKDVVGQLDVSILQEKVLRPVLGI
                     EDPRTDQRISFVGGSHKAAELAEIADRTGGVAFVMYPTSMEDLMKIADENKLMPPKSTW
                     FEPKLRSGLFIHKL"
     CDS             5787..7016
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_5"
                     /sec_met_domain="PALP (E-value: 4.1e-52, bitscore: 166.4,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEGLKWTVNEVPKSDDKHLELMSEENVKKANEFHRSFPQYSVTP
                     LQNLSSLAKYLGVKNIFCKDESYRFGLNAFKVLGGSYAMGRYIAKELGRDISELPYNVL
                     SSDKLREEFGQATFFTATDGNHGRGVAWAANRLGQKAVVRMPKGTTKTRFDNIVKEGAT
                     VTIEEVNYDDCVRMAAAEAAKTEHGIIVQDTAWDGYEEIPSWIMQGYGTLVLEADQQLK
                     EMGVERPTHVFVQAGVGSLAGAVVGYFAHKYKDNPPVMAVCEASAADCLYRSAVAKTGN
                     LVNVTGDLQTIMAGLACGEGNTIGWDILKNHVDVFASCPDWMSAKATRIYANPLGDDPH
                     VVSGESGSVPLGFCFTALHDEDAKDLKEALKLDENSVVLVISTEGDTDPVRYREIVWDG
                     LYGTNESLSK"
     CDS             7162..8472
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg75_6"
                     /sec_met_domain="Peptidase_M20 (E-value: 2.3e-25, bitscore:
                     78.6, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYAKINEAAMGYKDDMTKFLRDLVRIPGESCGEKGHIMRIKEEM
                     EKVGFDKVQIDPMGNILGYMGTGKTLIGFDAHIDTVGIGNIKNWEFDPYEGFESDEEIG
                     GRGTSDQMGGIVSAVYGAKIMKDLGLLNDKYQVLVTGTVQEEDCDGLCWQYIIHEDGVR
                     PEFVVSTEPTDGGIYRGQRGRMEIRVDVKGVSCHGSAPERGDNAIYKMADILQDIRALN
                     ENDAADTTEIKGLVKMLDEKYNPEWEEARFLGRGTVTTSEIFFTSPSRCAVADSCSVSL
                     DRRMTAGETWESCLDEIRALPAVQKYGDDVTVSMYEYNRPSYTDLVYPIECYFPTWVIP
                     KDHKVTQALEEAYKGLYGEERLGNAETEGMRKARPLTDKWTFSTNGVTIMGRNSIPCIG
                     FGPGAEAQAHAPNEKTWKIDLVRCAAVYAALPTAYCK"
     CDS             8679..9872
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: OTCace"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_7"
                     /sec_met_domain="OTCace (E-value: 9.9e-50, bitscore: 157.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 2.7e-31, bitscore:
                     97.7, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLQDYIDKLNSLNFKEMYNNDFFWTWDKTDDELEAVFTVADAL
                     RFMRENNISTKVFESGLGISIFRDNSTRTRFSFASACNLLGLEVQDLDEKKSQIAHGET
                     VRETANMVSFMADVIGIRDDMYIGKGHAYQKEFMEAVTEGNKDGILEQRPTLVNLQCDV
                     DHPTQCMADMLHIIHEFGGVENLKGKKIAMTWAYSPSYGKPLSVPQGVIGLMTRFGMDV
                     VLAHPEGYDVMPEVEEIAKKNAEKNGGSFTKTNDMAEAFKDADIVYPKSWAPFAAMEKR
                     TDLYAEGDFDGIDKLEKELLAQNAQHKDWACTEELMKTTKDGKALYLHCLPADITGVSC
                     ETGEVDASVFDRYRIPLYKEASFKPYIIAAMIMLSKFENPQDILKKLEVKAAPRILK"
     CDS             10074..11018
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_kinase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg75_8"
                     /sec_met_domain="AA_kinase (E-value: 4.7e-37, bitscore:
                     116.9, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFTRKRIVIALGGNALGNTLPEQMVAVKTTAKALCDLIEEGHQVV
                     VVHGNGPQVGMINNAMSALSREDENQPNTPLSVCVAMSQAYIGYDLQNALREELRIRGF
                     VRTPVVTVVTQVRVDPNDPAFENPSKPIGKFLTKEEADHQAKAYGHIMKEDAGRGYRRV
                     VASPKPVEIVEQDAINSLVDANKIVICCGGGGIPVVLNGHHLKGASAVIDKDYASCLLA
                     KELDADMLIILTAVEKVAVNFGKENEEWLDDITVDDAKKYINEGQFAPGSMLPKVQAAV
                     DFASSKEGRTAMITLLQKAKDGIQGKTGTKIHL"
ORIGIN
        1 cgtcctgtcc catacctgct acttccagag ttgcccatac cgggtcaccg gagaataact
       61 ggttgtaaga agggatacgt gcaaatttaa ccatacggaa tttcattacc atgtggtcaa
      121 caagctcctg agcttctttc tctgtaagag ttccgttctg aagatctctt tcaatataaa
      181 tatcaaggaa tgtggaaata cgtccgacac tcattgcagc accgttctga gttttgatgg
      241 ctgcaagata tccgaagtac agccactgga aagcttctct tgcatctttg gccggtttgg
      301 agatatcata tccataagat tcagccataa ctttcatgcc tttcagagca cggatctgat
      361 cagcgatctc ttcacgaagc tggaagtcat aacgtctcat accctgacgg tcgcatgctg
      421 cgaagtcttt ctgttttcct tcgatcagag cgtcgattcc gtacagagcc acacgtctgt
      481 agtcgccaac gatacgtcca cgtccgtaag tatccggaag acctgtaagg atcttgttgt
      541 gacgtgctac tttcatctca ggtgtgtaga tatcaaatac accctggttg tgagttttaa
      601 attcatagtt gtggaaaaca tctttaatct tgtcacttac tttatatccg taagtttcac
      661 aagcctgctc tgccattttg ataccgccgt atggcatgaa agcacgtttc agaggtttat
      721 ctgtctgaag accaacaact ttttcaaggt cttttgtttc ttcatcaata tatccgggac
      781 catatgctgt cagagatgta actacctctg tctccatatc aagaactccg cctttggcac
      841 gttcttcttt ctgaagtgcc tggagcttgc cccacagttt gtttgtagct tctgtaggtc
      901 cttccaggaa agaagcatca ccgtcatatg gtgtatagtt cattccaata aagttacgta
      961 catcgatttt ttctttccaa cggttgccct taaagccatt ccactgttcg aaatttttca
     1021 ttcttttacc tctttctcta aaatatttcc gcgcatttct cactggcctg gagtgagata
     1081 ataaaatgta aattgtactt atttaggaca cttttctgcc cacgctgtca gtatacgtaa
     1141 acatgagtgt tatgtcaatt aatttccctt atgattttaa ttaaatacaa ttctgatagc
     1201 ttttcatcgg agtttgcttc tttattgtac tttatcgcgt acattaagac tttcttgtat
     1261 ttttataaat acaaaaaaaa taccggtcag gaagtcctct ggacaatctg accggtatct
     1321 gatttttgat attttatgta aactatatta ttccctgcca agcggatatt agcctgacct
     1381 gcagaagtca aaaaacagca ggaaaaaatc gggcgtgtcg gaacaatcta acggttattg
     1441 atcgctgtta caagtgcatc aatagatgcg cgaatgatat ccgcgtctac gcctgcaccc
     1501 caggcaaggg ttccatccgg ctttttgata ccgacataag caatagcttt ggaacttgaa
     1561 ctgcgctcca gcgcatgttc ctgatatgtt tccagggaat atttcagctc atatgccttc
     1621 ttcagtgcat tgctgactgc atcaagacgt ccgttaccgg atgcctctgt agtgattgtc
     1681 tttccgcgga aagtagaggt aacttttgtt acaataccac catctttctg ctggaaatgt
     1741 acttcattga tgctgtacgg ttctgtgata ttctcaaagg tctgtttaaa cagattgaaa
     1801 atttcgtcag gatgaagctc tttatgtttg tggtctgaaa cagcttttgt ggcatatccc
     1861 attgcctcac gcattttcgg aggaaggttc agaccgaatt tggtctcaag aatatatcct
     1921 acgccgcctt taccggactg gctgttgatg cggataacat ctgcgtcata atttcttccc
     1981 acatctgtcg ggtcgatcgg aagatacgga acattccagt gatccggatc cttgtcatct
     2041 ctccagtgca tacccttggc aattgcatcc tgatgagagc cggaaaatgc ggcaaataca
     2101 agtgcaccac tgtacggact tctttcgcct actttcattc cggtacattc ttcatatatt
     2161 tcacagatat gcggcatatc agagaagtca agttttggat ctacaccctg agaatacata
     2221 ttcataccaa gtgtaacaat atctacattt ccggtacgct caccgtttcc gaacagagta
     2281 ccctcgattc tgtctgcacc tgcaagtaat cccatttcag aatctgcaac accgcatcct
     2341 ctgtcattgt gcggatggag agatacgatt acattctcgc ggtatttcag attttcacac
     2401 atatattcta cctggcttgc atatacatgc ggcatggaat gctgtacagt tacaggcaga
     2461 ttgatgatgc atttgttatc tgctgtaggc tgccatacat caagaactgc attgcatact
     2521 tccagagcgt attccggttc tgtgcctgta aagctttcag ggctgtactc aaactggaaa
     2581 tttccttctg tttcatcagc cagtttcttt aataatgcgg caccatccac tgcaatcttt
     2641 aagatttctt ctttggattt cttaaatacc tgttctctct gagctacaga ggtggaattg
     2701 tacacatgta caattgcctt cggtgcgcct ttgacagctt caaaagtttt gcggatgata
     2761 tgctctctgg cctgagtcag aacctgaata gttacatcct gtgggatcag attctgctcg
     2821 atcagggtac gcagaaattc atattctgtt tcagaagcag ccgggaaacc tacttcaatt
     2881 tctttgaaac cgatttttac aagaagttta aagaattcaa ttttctgttc cagactcatc
     2941 ggaatcacca gtgcctgatt accgtcacga aggtctacag aacaccagac aggtgctttg
     3001 tccacatatt ctttttctgc ccatttcatg catttaacag gcggcataaa atactgtctc
     3061 tgatatttgc ttggattcat cattttttct tcctccgtta tgtaaatatt atgtttggac
     3121 tgtggggatt gactgtaaaa agacataaaa aaatcttcca tctccacaga cttatctgca
     3181 agagacgaaa gatattatca tcttacgcgg taccactctt atttatgaac aatgtcatac
     3241 actcatggga tacggaatct ccggatatcc ggtattctta tatcctctcc atataacggt
     3301 ggaaaccgtc tgcacctact cttgtataat ttcaggcagc tgctcaaagg cgagttccac
     3361 aatttccttc cactgcttct cagcaaccag cagttctctg tgctccggtc cgggtgtact
     3421 attccttatc attgcatttt acttataact ttatttggct tttttgaaat gaaatgaaca
     3481 tacgtctgaa tcattcattg taaatatact acaaacgatt taaccatatg tcagtcgggg
     3541 caacaggatt tgaacctgcg acctcacggc ccccagccgt gcgcgctacc aagctacgcc
     3601 ataccccgta acgcaagtta gtataacaaa ttatttctgt gatttcaact gttttttgaa
     3661 aaattcacaa aaattataca aatttagcag gaagaaattt catgtacttt tttatgttat
     3721 aaaatttctt cctgtttatc ctatgtacaa gccttacaat catctgttac agttacgctg
     3781 gcatgatggc tttttccaaa ttgtctacac gcatatccag ttcaaaaact ttctctcgag
     3841 tttccttatt ctcctttcta tagcgaagct catccatacg tgcatcaaat agggcagata
     3901 tttttctgtc aatttcattt tccagtttaa gttctatagt ttttacgctt cccttgagtt
     3961 gcacaatatc tgatttcatg ttcgtgatat ccgtcttcat gtttgtgata tctgccttca
     4021 tgttcgtgat atctgtcttc atgtttgcaa tatctgtcct catatctgcg atatcgttct
     4081 ttacatcgga catatcattt tgaaaaccgg caatgcttcc ctgtatagaa aaaaggatat
     4141 ttctcaattc cgcatcttcc acattcttcc ctcctttcgt tatagtacgt ttcgttctct
     4201 tttgtataga accaattgta ccattgaagg aagaaaaagt ctacagcgaa attattataa
     4261 tatttttata agacatcttc ggcaaattat aacttatgta taaacagccc actccgaagt
     4321 tttggctcaa accaggtgga ttttggaggc attaatttgt tctcgtctgc aatcttcatc
     4381 aggtcttcca tagatgtcgg gtacatgaca aaggctacac cgccggttct gtccgcaatc
     4441 tctgccagct ctgctgcctt atggcttccg cccacaaagg agattctctg gtctgtgcgc
     4501 ggatcttcga ttcccaggac tggtctgagg actttttcct gaagaatgga tacatccagc
     4561 tgtccgacca cgtccttctt ctcatagata tccggccatg ctttcaggtg ataccactgt
     4621 ccgtccacat acattcccat acaatgcttc tctacaggct tgcatggaaa tcccggcatc
     4681 agcatcagtt caaagttgaa cttcagggcg cccagaaatg cctttacagt caggccgttc
     4741 aaatctttta caatcctgtt ataaggaaga atgcagagct ggtcataggg aaatacaaca
     4801 gacaggaaat aattaaactc ttcctcccct gtatatcccg gattctgttc tcttctcttt
     4861 aaacctactt ttacagcgga agctgcgcgg tgatgtccat ctgcgatgta cagagaatca
     4921 atccctgcaa attccttatt tatttcagaa atgacctcat cttcatcaat cacccatact
     4981 ctgtgtgtga tctgatcctc ttctgtaaaa tcatatgctg cttcatgatg atctttccag
     5041 ttattcatca gtgtaagcag agaatccgga tatctgcatg ccagaaaaat aggaccggta
     5101 tttgcattac aggaatctac atggtggatc ctgtcctgtt ccttatcttc tctggtaagc
     5161 tcatgtttct tcactacacc attcatataa tcatcaatgg aactgcatcc tacgataccg
     5221 gtctgtgtct ttccttttct tacaagttca tatatatagt aacaggcctt ctgatcctga
     5281 acaagaattc ccttttcttc catattgtca agattttctt ttgctttttc ataaacccga
     5341 tcatcataca gatctgtctc aggttccaga tccatttccg gtctgtcaat atgaagaaag
     5401 gacaggggat tctcatctcc gattgatttt gcttcttccc ggtttaccac atcatatgga
     5461 agtgctgcca catcagcagc cttttccggt gtaggtcgaa gtgcccggaa tgcatgaaat
     5521 actgccataa tattttctcc tcttctgtat cttttgtatt gctcttttat acccacttta
     5581 ctgtctatcc tgtaaaaata aaacgaacat tactcattat tttatcatat ccaaatcctt
     5641 atatcaatgt acaaattatg aaacctaatt tttttttgaa aaacctaaaa atttttgtat
     5701 ttttctattg caatttttaa aatatatggt atgatagaat cacaagttaa ggaaaccaaa
     5761 tgataatttt taagggaggt cattttatga cagaaggatt aaaatggact gtaaacgagg
     5821 ttccgaaatc agatgataaa cacctggaac tgatgtccga agaaaatgta aagaaagcaa
     5881 atgagttcca cagaagtttc ccacagtaca gtgtgacgcc tcttcagaac ctttcatccc
     5941 ttgcgaaata tttaggagta aaaaatattt tctgtaagga tgaatcctat cgctttggct
     6001 taaatgcttt caaagtactt ggaggttctt atgcaatggg ccgctatatc gcaaaagaac
     6061 ttggacgtga tatcagcgag ctgccataca atgttctctc ttctgataaa ttaagagaag
     6121 aattcggaca ggctacattc tttactgcaa cagacggtaa tcatggacgt ggagttgcat
     6181 gggcagctaa ccgccttgga cagaaagcag ttgtaagaat gcctaaggga acaacaaaga
     6241 ctcgtttcga taacattgtc aaagaaggtg ctactgttac gatcgaagaa gtaaactatg
     6301 atgactgcgt aagaatggct gcagcagaag ctgccaaaac agaacatggt atcatcgttc
     6361 aggataccgc atgggacgga tatgaagaaa ttccatcctg gatcatgcag ggatacggaa
     6421 cactggttct tgaggctgac cagcagttaa aagaaatggg tgttgaacgt ccgacacatg
     6481 tatttgttca ggccggtgtt ggttctttag caggtgccgt agtcggttat ttcgctcata
     6541 aatataaaga taacccgccg gttatggctg tctgtgaagc aagtgctgct gactgcctgt
     6601 accgctccgc tgttgcaaag acaggaaatc tggtaaatgt tacaggtgat cttcagacaa
     6661 ttatggccgg tcttgcatgc ggtgagggaa atacgatcgg gtgggatatc ctgaaaaatc
     6721 acgtagatgt atttgcatcc tgtcctgact ggatgagcgc aaaggcaaca cgtatctacg
     6781 ctaatccact gggagatgat ccacacgttg tctctggtga atccggttcc gttccgcttg
     6841 gtttctgctt cactgctctt cacgatgaag atgcaaaaga cttaaaagaa gcgctgaaac
     6901 tggatgagaa ttccgtagta cttgttattt ccacagaagg tgacactgat cctgttcgct
     6961 accgcgagat cgtatgggac ggattatacg gaacaaacga atctttaagc aaatgatgtt
     7021 tttggtgaac acagacaggt aagtggtatg gttatctcga aaatgatata ccagtaacta
     7081 ataatatgat atcagattag gggcaaaata ccttttgacc ctaacatcat aatattttat
     7141 acatattggg agggtaaaaa aatggattac gcaaaaatta acgaagctgc aatgggttat
     7201 aaggatgata tgactaagtt ccttcgcgat ctggttcgca ttcctggcga aagctgcgga
     7261 gaaaaaggac atatcatgag aatcaaagag gaaatggaaa aagtcggatt cgacaaagtt
     7321 cagatcgatc cgatgggcaa tatcctcggc tacatgggaa caggtaaaac tctcattggt
     7381 tttgacgctc atattgatac agtcggtatc ggtaatatca agaactggga atttgatcca
     7441 tacgaaggtt tcgaatctga tgaagaaatc ggcggacgtg gaacatctga ccagatgggc
     7501 ggtattgttt ctgcagtata cggtgctaag atcatgaaag accttggtct tttaaacgat
     7561 aaatatcagg tacttgtgac aggtactgta caggaagaag actgtgacgg tctctgctgg
     7621 cagtacatca tccatgaaga tggtgttcgt cctgaattcg ttgtttccac agaaccaaca
     7681 gacggcggta tctacagagg acagcgtgga cgtatggaaa tccgcgtaga tgtaaagggt
     7741 gtttcctgcc atggttccgc tccggaacgt ggtgacaatg caatctacaa aatggctgat
     7801 attctccagg atatccgcgc attaaacgaa aacgatgctg ctgataccac agagatcaaa
     7861 ggtcttgtaa aaatgcttga tgagaaatac aaccctgaat gggaagaagc acgtttcctt
     7921 ggacgtggca ctgttactac ttccgaaatc ttcttcacat ccccaagccg ctgtgcagta
     7981 gctgactcct gctctgtatc tcttgaccgt cgtatgacag caggcgaaac atgggaaagc
     8041 tgcctggatg agatccgtgc tcttccggct gtacagaaat atggcgacga cgtaacagta
     8101 tccatgtatg aatacaaccg tccgtcctat acagaccttg tatatccgat cgagtgctac
     8161 ttcccgacat gggtaatccc gaaagatcac aaagtaacac aggctctgga agaagcatat
     8221 aaaggactgt acggcgaaga gcgtctcgga aatgctgaga cagaaggcat gagaaaagct
     8281 cgtccgctta cagacaaatg gacattctct actaacggtg taacaatcat gggacgtaac
     8341 agcattcctt gtatcggatt cggacctggt gcagaagcac aggctcatgc tccgaacgaa
     8401 aaaacatgga agatcgacct tgtaagatgc gctgctgtat acgctgctct tccaactgca
     8461 tactgcaaat aataaataaa ttttcaaatt tttttaggcg acggatttcc tatcatccta
     8521 aaggcttaat atgtgtccgg acagaatccc tgctgtaaca ggcagggaca caagataaac
     8581 agatacagcc ggataaccgg tgttctgcca aacgcagaga ttcaattatt tcatatcagg
     8641 aaaggataag ctatcaaagc atagcaggta ttgattttat gaaaacatta caggattaca
     8701 ttgataaatt aaacagctta aacttcaaag aaatgtacaa caacgatttc ttctggacat
     8761 gggacaaaac agatgatgaa ctggaagctg ttttcacagt tgctgatgct ctccgtttca
     8821 tgagagagaa caatatctcc acaaaagtat tcgagagtgg tcttggaatc tctatcttcc
     8881 gcgataactc cacacgtaca cgtttctctt ttgcttccgc atgtaacctt cttggtctgg
     8941 aagtacagga tcttgatgaa aagaaatctc agatcgctca tggtgaaact gttcgcgaaa
     9001 cagcaaacat ggtgtctttc atggctgatg tgatcggtat ccgtgatgat atgtacatcg
     9061 gaaaaggaca tgcttaccag aaagaattca tggaagctgt tacagaagga aacaaagacg
     9121 gtatccttga gcagagacct actcttgtaa accttcagtg cgacgttgac catccgacac
     9181 agtgtatggc agatatgctc cacatcatcc atgaattcgg cggtgttgag aatctgaaag
     9241 gcaaaaagat cgctatgaca tgggcttact ctccatccta tggtaaacca ctctccgttc
     9301 cgcagggcgt tatcggtctg atgacacgtt tcggcatgga cgttgttctt gctcatccgg
     9361 aaggatatga tgtaatgccg gaagttgaag agattgccaa gaagaatgct gagaaaaacg
     9421 gcggatcctt cacaaagaca aacgatatgg ctgaagcttt caaagatgct gatatcgtat
     9481 atccaaagag ctgggctcca tttgcagcta tggaaaaacg tacagacctt tatgcagaag
     9541 gcgacttcga cggaatcgat aaattagaga aagaacttct tgcacagaat gcacagcaca
     9601 aagactgggc ctgcacagaa gaacttatga aaacaacaaa agacggaaaa gctctttacc
     9661 tgcactgcct gccggctgat attacaggtg taagctgcga aacaggtgag gttgacgctt
     9721 ctgtattcga tcgttacaga atcccgttat acaaagaagc aagcttcaaa ccatacatca
     9781 tcgctgctat gatcatgctt tccaaatttg aaaatccaca ggatatcctg aagaaacttg
     9841 aagtcaaagc agctccaaga atcctgaaat aatcaggcgc agattaacag ttggattgca
     9901 gtaatattcc agctgctttc aaacagatat ttaattttga aagcagtttc agaatttaaa
     9961 tatattgaaa aatagtactc atcatattgt atagcaggcg gggctgtcgc agaaagcaca
    10021 caatctttat tgcggcggcc ctctttgcct ttaaaatcag gaggttttta caaatgttta
    10081 caagaaaaag aatcgttatt gcgctcggtg ggaacgctct gggaaatact ctcccggaac
    10141 agatggtagc tgtaaaaact actgcaaaag cattatgcga tctgatcgaa gaaggtcatc
    10201 aggttgttgt tgtacatgga aacgggccac aggttggcat gatcaacaat gccatgtctg
    10261 ctctctccag agaagatgag aatcagccaa acactcctct ctctgtctgt gttgccatga
    10321 gtcaggctta catcggatat gatctgcaga atgctttgag agaggaactt cgaatcagag
    10381 gatttgtccg cacacctgtc gtcactgttg tcactcaggt tcgtgtagat cccaatgatc
    10441 ctgcttttga aaatccatcc aagccgatcg gcaaattcct gacaaaagag gaagcagacc
    10501 atcaggccaa ggcatatgga catatcatga aagaagacgc agggcgtggt tatcgtcgtg
    10561 tagttgcatc tccaaagcct gttgaaatcg ttgaacagga tgcgatcaac agtcttgtgg
    10621 atgcaaataa aatcgttatc tgctgcggtg gcggcggaat tcccgttgtt cttaacggac
    10681 atcatctcaa aggtgcatca gcagttattg ataaggatta tgcaagctgt ctcctggcca
    10741 aagagctgga tgcagatatg cttatcattc ttacagcagt ggagaaggtt gctgtaaact
    10801 tcggcaagga aaacgaagaa tggctggatg acatcactgt agatgacgct aagaaatata
    10861 ttaatgaggg acagtttgcc ccaggttcca tgctcccgaa agttcaggct gccgttgatt
    10921 ttgcaagctc caaagaagga agaactgcca tgatcacttt acttcagaaa gccaaagacg
    10981 gtatccaggg aaaaaccgga accaaaatcc atctttaatc tgttcagcag atatcttatt
    11041 atatatcagc tgtttaatac tgatatatat aactgccaca tattcaggat atctgctata
    11101 tagcgaaata attgcgcaaa aaaagttccg gtgacctcgc ccggaacttt ttttgtgatg
    11161 agtggaccag agtgtctgga aaatcattcc tgcaatctgc acgccccact tttcggtata
    11221 ttttgacata catcttgcgg aaagcatttt tcagacacac tttagtacat cgttttcgaa
    11281 ataactatac cactcacttg tctgcgaatc cgattgc
//
