LOCUS       c00073_gnlPro..        15601 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BCIHOEHD_73.
ACCESSION   c00073_gnlPro..
VERSION     c00073_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:35:52
            Original ID  :: gnl|Prokka|BCIHOEHD_73
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15601
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15601
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6860:11568]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6861..11568
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15601
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15601
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(167..418)
                     /locus_tag="ctg73_1"
                     /transl_table=11
                     /translation="MKKGIHPENYRPVVFKDMSNGDVFLSRSTCNTKETIEFEGETYPL
                     VKLEISSTSHPFYTGKSKLVDTAGRVDKFMSRYGNRKK"
     CDS             607..1614
                     /locus_tag="ctg73_2"
                     /transl_table=11
                     /translation="MRKLLVLCSFWLCVATLGAQNAERKLYSVAFYNLENLFDTIHDAG
                     KNDYEFLPDGSYQWTAKKYESKLQNLSKVLGSLSRDLVPEGPAFIGVAEAENSRVLEDL
                     VKQPAISNYEFVHYEGPDRRGIDCALLYDPKQFSVTHSKLVLSTPFEGDTVHLTRGFLI
                     VDGQLAGERVCVIVNHWPSRGAKSPVRVHAARQVKALKDSLMRSDKKLKLIVMGDMNDD
                     PMDESMEVLGARKYPKQVKKGEFYNPWWETLEDKGVGTLLYRGKWNLFDQIVISKPLLK
                     AKKGLRYDHNEVFIRDYLIQQDGKYKGSPLRTHGGRTWLNGYSDHLPTIIYLKN"
     CDS             1897..2907
                     /locus_tag="ctg73_3"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVDYAHQFDVTVEGELGVLAGVEDEVSAEHHT
                     YTNPEEVIDFATRTGCDSLAISIGTSHGAYKFKPEQCHVDPATGRLVPPPLEFAVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVDTINKYGGKLEAAIGIPEEQLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSENKLAQLD"
     CDS             complement(3378..5228)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg73_4"
                     /sec_met_domain="Alpha-amylase (E-value: 2.3e-64, bitscore:
                     207.8, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKE
                     YELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMAEYKIDRNDPNARHGG
                     DLAGIEQHLDYFSDLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQL
                     IEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPY
                     TSQYDADQMNDGWFVPSMPDLNQKNPHVYRYLVQNSFWWIEFANIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPKNSNLKTVMDFSFFDKI
                     NTAKNEQTETWFKGLDRIYNNFVYDFLYPNPASVLAFIENHDTDRFLGEGNNLPMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTGDATNALTPAGRTKIQNE
                     CYDFYKTILNWRKGNDVIAKGSMVQFMVQNGVYAYARQYEGKTIFVMLNGTDAETTVPL
                     KFYKEILKNSKQGKDILSGKAITFGEELKMGPRESLVIEL"
     CDS             complement(5339..6691)
                     /locus_tag="ctg73_5"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVAQDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSAYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAISITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVMSRLYVGLADCYKMAF
                     QYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDASKAERYLTAYLKTRPKNSKDK
                     VQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKVDTASVTPIK"
     CDS             complement(6861..8021)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_6"
                     /sec_met_domain="OAD_beta (E-value: 5e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(8023..8346)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 68.4; E-value:
                     1.2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.6e-22, bitscore:
                     68.4, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKAPKVVVKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPL
                     PGVILDIKVNVGDTVKKGQVIIILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLV
                     IIE"
     CDS             complement(8480..9412)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_8"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-17, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(9444..10997)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_9"
                     /sec_met_domain="CT_Btheta (E-value: 1.4e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(11056..11568)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_10"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4.2e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             11762..13249
                     /locus_tag="ctg73_11"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             13393..14754
                     /locus_tag="ctg73_12"
                     /transl_table=11
                     /translation="MILIIDDDSAVRSSLSFMLKRAGYEVKTAPSPREAMDIVRAEAPA
                     LILMDMNFTLSTTGEEGLTLLKQVKVFRPDVPVILMTAWGSIQLAVQGMQAGAFDFITK
                     PWNNAALLQRIETALELTAAPKEVPEEQTTALNRSHIIGKSKGLMEVLNTVARIARTNA
                     SVLITGESGTGKELIAEAIHINSQRVKQPFVKVNLGGISQSLFESEMFGHKKGAFTDAS
                     ADRIGRFEMANKGTIFLDEIGDLDPSCQVKLLRVLQDQTFEVLGDSRPRKVDVRVVSAT
                     NADLRKMVSERTFREDLFYRINLITVKLPSLRERREDIPLLARHFADRQAEVNGLPRTD
                     FSADALNFLSRLPYPGNIRELKNLVERTILVSGKPVLDATDFDAQYLRHDEPAKAAEGT
                     SFAGMTLDEIERQTILQALEQHKGNLSQVAVSLGISRAALYRRLEKYNIQVPCA"
     CDS             14745..15599
                     /locus_tag="ctg73_13"
                     /transl_table=11
                     /translation="VRIKFFFFILVLFLLGLGGMLVYLLSGKPSLYLYVLEGLIGFILI
                     YLIVFYNKIVKPMNTIGSGMELLREQDFSSRLSRVGQYEADRIVNIFNRMMEQLKNERL
                     RMREQNHFLDLLIQASPMGVIILTMDDEVSQLNPMAVKMLGVRMEEAMAKRLDQMDSPL
                     AAELSSIPKDETAVVRLNDANIYKCTHSSFIDRGFKHPFFLIERMTEEVMRAEKRAYEK
                     VIRMIAHEVNNTTAGITSTLDTVEQALSTEDDMEDICDVMRVCTERCFSMSRFITRFAD
                     VVKI"
ORIGIN
        1 gttttcggtt tcgatgatac aaaaatagga aagtgttttt cccctttctt gttttttccc
       61 ctattctgtg ataggagatt ccctatttat cgctcagcgg gaggcggaaa caaaaaaggg
      121 aacctttcag tgaaagactc ccttttttca gtttgcttga aactgattat ttcttacggt
      181 taccgtaacg gctcatgaac ttatcaacac gaccggcagt gtcaaccagc ttagacttac
      241 ctgtgtagaa cgggtgagaa gtgctggaga tttccagctt taccagcgga taagtttcac
      301 cttcgaattc gatagtctct ttcgtgttgc aagtggaacg agacaagaat acatcaccat
      361 ttgacatatc tttaaatact accggacggt aattttcagg atgaatacct tttttcattt
      421 tgatattttc ttttaaaaat ttatattctg ttactatttt ggtaataaat agtgtaatgg
      481 tcttcttttc agagcgcaaa gatagtgcaa gttggagact ctacaaaata aattcagatt
      541 tatttttatt tagtaggttt atcgcatttt atttctgatt tttgcaggac ttaatcttgt
      601 gaatttatga ggaaactact tgtcttatgc tctttctggc tgtgcgtggc aacgctgggg
      661 gcacaaaatg cggaacggaa actgtatagt gttgcgttct acaatcttga gaacttgttt
      721 gatacgattc atgatgcagg taagaatgac tatgagttcc tgcccgacgg cagttaccaa
      781 tggacggcaa agaagtatga gtccaagctg cagaaccttt ccaaagtgtt gggttccctt
      841 tcgcgtgatt tagtgccgga aggtccggca ttcatcggtg tggcagaggc ggagaacagc
      901 cgggtgctgg aagacctcgt gaagcagccg gccatttcca attatgagtt cgtgcattat
      961 gaaggaccgg acagacgggg catcgactgt gccttgctgt acgacccgaa gcagttcagc
     1021 gttacccact caaagttggt gctttctact ccttttgagg gggatacggt gcacttgacg
     1081 cgcggcttcc tgattgtgga cggacaactg gcgggagagc gtgtctgcgt gatagtgaac
     1141 cactggccct cccgtggggc aaagtcaccg gtgcgtgtgc atgcagccag gcaggtaaag
     1201 gccttgaagg actctctgat gcgtagcgac aagaagctga aactcatcgt gatgggggat
     1261 atgaatgacg acccgatgga tgaaagcatg gaggtgctgg gtgcacgcaa atatccgaag
     1321 caggtgaaga aaggcgaatt ctacaatccc tggtgggaga cactggaaga caagggagtg
     1381 gggacattgc tctatcgggg caagtggaac ttgtttgacc agattgtcat ttcgaaaccg
     1441 ttgctgaagg ctaagaaagg gttgcgctat gatcacaatg aagttttcat ccgcgattat
     1501 ctgattcagc aggatggcaa atacaaaggt tcccccttgc gtacgcatgg gggcaggact
     1561 tggctgaacg gttacagtga ccatttgccg accatcatct atctgaaaaa ttagtattac
     1621 ataataatgt gtaaacagat gccggagagc aaacatgttc tccggctttt ttgttgatag
     1681 aagtatagat ggcaaaagta tggctggcag agataaatgc aaagagtttg taatatagag
     1741 attacaataa tctgttaaat gaagccaata gctttaaaat agaatggatt tggtaggatg
     1801 agccggatat tttattcctc tcaagttctt tactttaaag gataatgatt acttttgcgt
     1861 agaattttaa ttcactaaca ataaaattta aacaaaatgg ttaattacaa agatttagga
     1921 ctggtaaaca caagagagat gtttgctaag gctatcaaag gtggatatgc tattccggca
     1981 ttcaacttca acaatatgga acagatgcag gctatcatca aggctgcagt tgaaacaaag
     2041 tctccggtta ttcttcaggt atctaagggt gcccgtcagt atgccaacgc tactctgttg
     2101 cgttacatgg ctcagggtgc tgttgagtac gctaaggaat tgggttgcaa acatcctgaa
     2161 attgttcttc acctcgacca cggagataca ttcgaaactt gcaagagctg tatcgactct
     2221 ggtttctctt cagtaatgat tgacggttca caccttccgt acgaagaaaa cgttgcactg
     2281 actaagaagg tagttgatta tgctcatcag ttcgacgtaa ctgtagaagg cgaactcggt
     2341 gtattggccg gtgtagaaga tgaagtttct gcagaacacc atacatatac taatcctgaa
     2401 gaagttattg acttcgctac ccgtacaggt tgcgattcac tggctatctc aatcggtact
     2461 tctcacggtg catacaagtt caaacccgaa caatgccacg ttgaccctgc taccggtcgt
     2521 ctggttcctc ctcctttgga atttgccgtt ctggatgctg taatggagaa acttccggga
     2581 ttccccatcg ttcttcacgg ttcttcttca gttcctcagg aagaagttga tactatcaac
     2641 aagtatggtg gtaagctgga agctgctatc ggtatccccg aagagcagtt gcgtaaggct
     2701 gccaagtctg ctgtttgcaa aatcaacatc gactctgact cacgtctggc tatgacagct
     2761 gctatccgca agacatttgc tgaaaaaccg gcagaattcg acccgcgtaa gtatctgggt
     2821 ccggctcgtg acaatatgga aaaactgtac aagcataaaa tcatcaacgt gcttggttca
     2881 gagaacaaat tggctcaact ggactaatcg aaagataatc cgaatatagc gtcagccctt
     2941 gcaatattga tgttgcaagg gctgacttgt tgtatatagg ccggtgttgt gggatggtta
     3001 agttcgccgg ttatttcaga agcggatgtt tcaacgtgta caacagtctg tttcctttaa
     3061 caaaacagtc tgtttccctt aactgaacag tttgtttcaa taaagagaac acttcgttcc
     3121 aatatgcaaa aacacttcgt tccaatacgt aagaacactt tgtttctaca tatccgaaca
     3181 ctttgtttct ctatactgga acaaagtgtt caccgttatg aactaacaga ttagctatat
     3241 ttgagaccgg tgaaaagcat atccccgtga cacctattcc atactaaaaa tcccttgcag
     3301 atggctggca ggcgaggtgt ctgcaagcta tctgcaaggg agatttgcaa gaatgagctc
     3361 tctgtgtgga gtgcgcgtta taattctatc actaatgatt ctctggggcc catcttcagc
     3421 tcttcaccga aggtgatggc cttgccgcta agaatatctt ttccctgctt gctgtttttc
     3481 aggatttcct tgtagaattt caaaggaacg gtggtctctg catctgtacc gttcagcatc
     3541 acgaatatcg tcttgccttc gtactggcgt gcgtaggcat aaacaccatt ctgtaccatg
     3601 aactgcacca tgctgccttt ggcaatcaca tcgtttcctt tgcgccagtt caggatggtc
     3661 ttgtagaagt cgtagcactc gttctgtatt ttggtacgtc cggctggggt cagtgcgttt
     3721 gttgcgtcac cggtccatcc gccggggaag tccttgcgga catagccgtc gctcttgctc
     3781 ttcacgccat tcatcatgac ttccgttccg tagtagagtt gcggaatgcg gcgggtggta
     3841 agcagcaggg tagaggcttg cttcagcatc ggaaggttgt tgccttcgcc caggaagcgg
     3901 tcggtgtcgt ggttttcgat gaatgccagt acggaagcgg ggttggggta gaggaagtcg
     3961 tatacgaagt tattgtatat gcggtccagt cccttgaacc aagtttcggt ctgttcattc
     4021 ttggcggtgt ttatcttgtc gaagaagctg aagtccataa cggtcttgag gttactgttc
     4081 ttgggggctg atagcttgga atccttctgc caccaggcgg tgtaggcggg ttcggtaacc
     4141 caggtctcgc ccacggtgtt gtagttggga tattcttcgt tgagctcttt catccagttg
     4201 ctcatggcat catagtcggc atacgggtaa gtgtccatgc ggatgccgtc gatgttggcg
     4261 aattcaatcc accagaaact gttctgtacc aggtagcggt aaacgtgagg attcttctgg
     4321 ttgaggtcgg gcatggaagg tacaaaccag ccgtcgttca tctggtcggc atcgtactgg
     4381 gaagtataag ggtctacgtg cggggtcagt ttgaaggagg tctgcacgaa gttgttttcg
     4441 tggtcggggt tgttgaacca atctttggag ggcatgtcct taatccatac atgctctacg
     4501 ccgcagtggt tgaaaatcat gtccattacg attttgatgc cgcgtgcatg ggctttttca
     4561 atcagctgct tgtattcttc gttggtaccg aagcgcgggt ctaccttgta gtagtctgtg
     4621 gtggcatagc cgtgatagga accgccggtc atgttgtttt ccagtaccgg agtaaaccag
     4681 agggctgtga cgccgaggtc ggagaagtag tccaggtgtt gttcgatgcc ggcaaggtca
     4741 ccgccgtggc gtgcattggg gtcattgcgg tctatcttgt actcggccat gcccgcaatc
     4801 tggtcattgt ccggattgcc attggcaaag cggtcgggca tcagcaggta cagtgcgtcg
     4861 gaggcgtcga aacctttatg ttcgcaacct ttcttgttgc gtgccttcag ttcatattcc
     4921 tttacgagtt tcttttttcc ttcagtgaag gtgaggttga atttgccggg ttttacatcc
     4981 ttgtccagtt tcagatagac caggaggtag ttgttgcttt ccagcttgac ggtgctgctc
     5041 aatgagacgc cgggataatt gacggatact gccgcgttgc cgatgccttc gccatagacc
     5101 atcagctgga gttccgggtt ctgcatgccg gtgtaccaaa acggagggtc gattttgttc
     5161 acattcatag ctgcatacgt actgagggag agtaagagtg ttcccaagat taagaatact
     5221 tttttcatga tagtaacttt acggttaatt tttgcgctaa tttaaaacaa ataacggaga
     5281 aagttaatct ttctccgtta ctgtacctta ttatattatg caaacgtttt cattggggct
     5341 atttgatggg ggttacgctg gcggtatcga cctttccctt gaagaagtcc tctttcttgc
     5401 gcttttctct gatgtccttc agccagtttt cggcggcatt gtatcggttg tcttctccga
     5461 tgatgggaac tccgtccgca tctacttcct gcactttgtc cttgctgttt ttcggacggg
     5521 ttttcaggta ggccgttagg tatctctctg ctttggacgc atctttcaga tagtaataat
     5581 agataaaggc tgcgtcgtag agcagtttgt gtttctgccg gtcgtatttt tcgtattgcg
     5641 tcagaagggt attcgcctgg tcggtgtatt gaaatgccat cttgtagcag tccgcaagcc
     5701 ccacatatag gcgggacatg acactgtcgc tgggcatggc gaggcttacg gcagtttcca
     5761 gataagtcac tccatcctct ttccatgatg tcttggagca ggcgcgtccc agataataga
     5821 gaacgttgat gttggtattg tcatctttaa gagccctttc cagcaggtcg tgtgctgggt
     5881 agaagtcttc gagggcataa tagctgattc cggcgtagaa gcaggtttgg aaagaactgt
     5941 ctttttcctg taacagttgt tcatatcttt ctattgcttt ggggtaatct ttgttcaggc
     6001 aataggcttg ggcattgatg cggttcacaa ggacgttggt ggagtctatg gaacggtatt
     6061 tctccgttat gcttatggcg tcttcatact ggtggcctgc tacatagatg ttgccgagtt
     6121 tggcagcaga caggtaatca ttgggatatc ttttctgtat gtccaggtag gcatctatca
     6181 catgcatgat ttctgtgttg tcatagactt gccccatact ttcggctcta aggtgtagta
     6241 cataggcgga actgtccctt tctgccagca ggttactttc ctttagagac tcacggtatc
     6301 tcttcatgtt catcagcaga ctgatatact ggatgcgtgc gtatttattg tccggattta
     6361 tgtggagcgc attttggtag taatccagtg cctcgctata tttggcaagt gatttgcagc
     6421 attcggcagc ttcaatgtat gcccggggat tgagagaatc ctgagctacg acttcctgaa
     6481 atacgctcag agcttcaagg ttattgccca gccctttcag cgctttccct ttttggtaga
     6541 gtagggggac ggtcggggtt tcttgatcga tcagcatcaa ggctgtttca taatcgtagt
     6601 tggccatcgc ctcttgaatg ggatttgtgg tctgtgccgc cagaagcgaa cagcatgcac
     6661 tgaaacataa ggagataaaa agctttcgca tacagtatat catttatatg aggttaaact
     6721 gactgcaagt tactaaaaag aatgtattta cgaaataatc gtaatctgtt ttagatagat
     6781 taacgaaaaa gcccctccaa aaatgaaggg gctctaaaat agttcagaat tcaagccgga
     6841 taacggaatg aataaatgta ttacattaag aatcccagca ggatacctgc tgctacagcg
     6901 gaaccgatta caccggcaac gttcgggccc atggcatgca tcagcagata gttggtagga
     6961 tcgtattcca gacctactac ttgggagata cgtgcagagt cgggtacggc agatacaccg
     7021 gcattaccga tcaacggatt aatcttgttg cctttcttca ggaagaggtt gaaaatcttc
     7081 acgaagatga caccggatgc tgtggcaatg acaaatgata aggcgcccag accgaatatc
     7141 ttgattgaat caagggttaa gaactcggat gcttgcgtag aagcacctac tgtcaaacca
     7201 agcagaatag taatggtatc aatcagcgga ccactggctg tgtttgccag acgacgtgta
     7261 actccacttt ctttcagtaa attaccgaag aacagcatac ccagcaaagg cagaccggat
     7321 ggtacaagga atgtggttag taacaaaccg ataatcggga acattacttt ttccgtatgt
     7381 gaaaccacac ggggaggttt catacggata agacgttcat ttttactggt cagccaacgc
     7441 ataataggcg gctgtatcac cggtactaat gccatatatg aataggctga taccgcaatg
     7501 gcacccatta agttaggagc cagtttggaa gagaggaaga tggcagtcgg accatcggca
     7561 ccaccaatga taccgattgc accagcctgc atcgggtcaa atcctatggc aagggcaatc
     7621 atataagcac cgaatatacc gaattgggct gctgcaccaa ccaacattaa tttggggttc
     7681 gatatcaaag cagagaaatc cgtcatggca ccgataccca ggaatatgag tggcgggtac
     7741 caaccggagg ttactccctg gtacagaata ttaagtacag aaccttcttc atagataccg
     7801 actttcaatc cggcttccat attgaaaggt atattaccaa tcagcatacc gaaaccgata
     7861 ggaattaata gcatcggctc aaattccttg gctacagcca agtatatgaa aaacaaacct
     7921 accagaagca ttaccacatg tcctaccgtt gcattggcaa aacctgtata agtccagaag
     7981 tcggcaaggt tgtttcctaa aaatgtgata aattctccca tattattcaa taattacgag
     8041 gtcagtacct tcgagaacag agtccccttt gtttacattg atggctgtaa tcttaccgtc
     8101 tttatcagca ttgatattgt tttccatctt catggcttcc aaaatgatga taacttgtcc
     8161 cttctttact gtatcgccga catttacttt gatatcgagg attacaccgg gaagcggaga
     8221 ttttacacct gacttgccgg tagaagcagc ggccggtttt actaccggag tagcaggagc
     8281 agcaggagcg gatgtggctg ccggacgtgc taccggttta acaactacct tcggtgcttt
     8341 ttccatttca actttgtagg gagtaccgtt cacttctaca tgagcgatgt tgtcttcaat
     8401 atctccaatg gcaactttat atacgttacc gttaatttta tatttatatt cttcatcgtt
     8461 ttattttatt atgggtgact tactttttgt gaggagtctc acgcaacgta taaatctttg
     8521 aactccacgg tgagtaactg cgttttacac gggtaatggt aagtatcgtg tcttccacat
     8581 cgtgtacatc gctttggaat tcgtgcatgg ccattgaaat ggcagcaaaa acttctcccg
     8641 gagcctgccc cagttgtttc tcttttgctt cttgtttatc agtaatacct ttagctttca
     8701 tggcattgcg tttgctgagg ttaactgata ttttacctat aatcttgaag gagatgtaga
     8761 gtaatatcag cccgcagaat acaacgctca tggcagaaat agccataccg atacctacgc
     8821 tgtcatgctc ttcgaatttt tccattttgg cattgctgtc gatagtcttg ttgttggtac
     8881 tcggagtgac atatttatct tcgcttccac cctttacttc ccattggtcg gctgcatcac
     8941 tgacacgggc ataggattgg ttggctttta aagtaccggc aggcactatg acttgatcaa
     9001 gcaatttctt gccggaatca tacaacccaa tccagttggc atttgtggca tccagtttga
     9061 agttcgtatg aaatgtaccg cgtcttggtt ctccatcagc ccagaaaagt gcatgctgac
     9121 gtggttttat gagtgtcaga acgtcacctt tgggaatgaa ataactggca gtatcacccg
     9181 gctggctgct gaatttcaga tagcaacctg caaggtcggc gctgccgtat gatctgttga
     9241 atatttcaat ccatgcgctg tgcacaccgt agtcatcctg atagttgctc tcgttgttga
     9301 ccagcacttc attcagcagc agtttgttgt tcgatttctg ttctttgcaa gaagagcaaa
     9361 agcccaacac cagcatcaat gaaaggaata ttccgatttt tgttttattc ataatcgttc
     9421 ttgttttagt gtgaaaagct tgattacaag ggaatattac catgcttctt agccgggtta
     9481 gtcaatttct tggtttgcaa ctgttgcagg gcacgaatga tgcggaaacg tgtgttacgc
     9541 ggttcgataa catcatcaat gtagccatat ttagctgcat tataaggatt ggcaaacaac
     9601 ttggtgtatt cagcctcttt ttcagccagg aattgagccg gattttcctg ctctttggct
     9661 tcgcgggcat ataatacttc tacagcacct gcaccaccca ttacagcgat ttcagcagta
     9721 ggccaagcat aattcatgtc gccacgcagc tgcttacagc tcatcacgat gtgcgaacca
     9781 ccgtaggatt tacgcagtgt gatggtaacc ttgggtacag tagcttcacc gtatgcatac
     9841 agcagtttgg caccgtgcag gatgacgccg ttgtactcct ggccggttcc cggaaggaat
     9901 cccggtacgt ctaccaatga tacgatagga atattgaagg cgtcgcagaa acggacgaag
     9961 cgtgcgccct tgcgggatgc gttgctgtcg agcacacctg ccagatactt cggctggttg
    10021 gcaacaatac ctacggactg tccgttgaaa cgtgcgaaac caataatgat attctttgaa
    10081 taatcttttt ggatttcgag gaactcacca ttatctatga tagcaccaat tacctcgtac
    10141 atatcgtacg gcttgttcgg gttatcagga atgatgtcgt tcagggaatc ttccagacgg
    10201 tcgatagggt ctgtacagtc tacataggga gcttcttcca ggttgttctg gggaatgtag
    10261 ctcaacagtt tgcggataag agccaaacct tcttcttctg tctgtgcagt aaaatgagta
    10321 acaccagatt tggtggagtg aacgctcgcg ccacccaggt tttcctggct tacgtcttct
    10381 ccggttacag tctttactac cttcggaccg gtaaggaaca tgtaggatgt accttccatc
    10441 atcaaagtaa agtctgtcaa ggcaggagag taaacggcgc caccggcaca aggaccgaaa
    10501 ataccggaaa tctgcggaat gacacccgaa gcaagtatgt tacgttggaa gatttcagcg
    10561 tagccagcca aggcattaat accttcctga atacgtgcac cgcccgagtc gttgataccg
    10621 atacacggag cacccatttt catggcttgg tccataatct tacagatttt cagagacatg
    10681 gtttcggaca gtgaaccggc agaaactgtg aagtcctgtg cgaagatata aaccagacgg
    10741 ccttcgattg taccgcaacc ggttactaca ccgtcaccgg ggtagtgttt cttttccatg
    10801 ccgaagttgg tgcatctatg ttctacgaac atgtccattt cttcgaaact gccttcgtcg
    10861 agaagcatgg ctatgcgctc gcgagctgta tatttaccct tctcgtgttg ctttgcaatc
    10921 gctttttcac caccaccgag acgtgctgca gcgcggcggt ctataagctc tttaatcttt
    10981 tcaagttgat tactcatgaa tttatattct ttaagtgttt atacaattta tgatttgatg
    11041 attttacagt cttgcttatt ccggtttctc gcaaagctcg gtcaggacac cgagagttga
    11101 cttcggatgc aggaatgcaa tgttcagacc ttctgcacct ttgcggggag ctttgtctat
    11161 aaggcggata cctttttctt cgacttcggc aagcgcaccg gccactccgt cttcaacggc
    11221 gaatgcgaga tgatgcatgc caccgttacc gttgttcttt tcgatgaact tggcaattgt
    11281 gctttcggga gaagtaggtt ccaacaattc gatctttaca tcgcccactt tcaggaaagc
    11341 ggttctaact ttctgatctt ccacggtttc gatgttgtag catttcaaac ctaaaacgtt
    11401 ttcgtagtac ggaagggctt cttcaatgct cttaacggca atgcccagat gctcaatgtg
    11461 tgaaatcttc ataactatat aaattaatgt tagtattgta tcctttttaa taaaggtata
    11521 aagcagcaca aagaaagaga attcttcctt aataaagaaa tttttcatca attaattaat
    11581 ggttaattga actttagaag gattttttca gactttagat agagaccggt tgttttcttg
    11641 atatcgtccg ctaacggaca tccccactgt ccgaaaatga acacttaccc ctctatgaaa
    11701 cctttccggc cacttggcac actctttgct tttctgtttg cgacaatttt aaagattgaa
    11761 catgaaaaag aatattttac ttgcagtttg ttttttgatg ccgttggcaa ccatggcgca
    11821 gaatgatact ttgggacatg aacgcaatat tacgctgtcg gaggccattg tactggcccg
    11881 tacgcagtct gtggatgctg ctgtggcatt gaatgaattg aaaaccgcgt attgggaata
    11941 ccgtacattc cgtgcggact tgttgccgga agtgaatttc accggtacac tacccaacta
    12001 taacaagtcc tacagtacct accagaattc cgacggctcc tatagctttg tccgcaacaa
    12061 tacactgggg ctgtccggac agctttcggt agaccagaac atttggttta cggggggtaa
    12121 gctgtcactg acttcttcgc tggattatct caaacaactg ggttccggag gagcgaagca
    12181 gttcatgtca gtccccgtga gtctggagtt gacgcaaccg gtcttcggag tgaatacctt
    12241 gaagtggaac cgccgtatag agcccgtacg ctatgccgag gcaaaggccg agttcatttc
    12301 agctacggaa gaggtgacga tgaaaaccat cacttatttc tttgagttgc tgctggccaa
    12361 agaatcgctc gctaccgcca tgcagaacaa gacgaatgcc gaccgccttt atgaagtggc
    12421 catagccaaa cgtaaaatgg gacagatatc cgagaatgat ttgttgcagc ttaaactgaa
    12481 ttcattgcag ggcaaggccg acgtgactga ggcagagagc aacctgaatg caaaaatgtt
    12541 ccagctccgt tctttcctcg gggtgtccga gcaggaaagc ctgaatccgg tgttgcccgc
    12601 cactgttccc gatataaaga tggagtatga ccgtgtgctg aacaaggcac tggaacgcaa
    12661 ctcctttgca cagaacattc gccgccgcca gctcgaagct gattatgaag tggcaacggc
    12721 acgcggaaac ttgcgcagca tcgacctctt tgccagtgtg ggctatacgg ggcagaacca
    12781 tgaattctct tcagcctacc gggacttgct tgataatcag attgtgcagg taggcgtcaa
    12841 gattcctatc cttgactggg gcaagcgccg cggcaaggta agggtggcaa agagcaaccg
    12901 tgaagtggtc ttgtccagaa tccgtcagga acagatggac tttaaccagg acatcttttt
    12961 gctggtggct aacttcaaca accaggcgca acagctggac atagccgaag aggcggatgt
    13021 cattgctgag aagcgttaca agaccagtgt agagaccttt atgataggta aaatcagcac
    13081 cctggacctg aacgatgcac agaactctaa agacgaagcc cgtcaaaagc atatttcaga
    13141 gctgtactac tattggtatt acttctatca gctccgcagc ttgacccttt gggattttga
    13201 acgcgatacg gaattggaag ctgattttga agaggtggta agaggataag tcgacgggtt
    13261 gcaagtgata agttatgaat tatttgccgg taaaagtacc gtatatgcga tattataggt
    13321 gaataactta taacttatca ttcataactc tgctttttta cttatttttg cgggaaacaa
    13381 actacaattt ttatgatact gataatagac gacgatagtg ctgtgcgctc ttccctcagc
    13441 tttatgctga agcgtgccgg atatgaggtg aaaacggctc caagtcctcg cgaagctatg
    13501 gacatagtta gggccgaagc tcccgccttg attttgatgg atatgaactt cactctttcc
    13561 actaccggag aagagggact taccttattg aagcaggtaa aggtgttccg tcccgatgtg
    13621 cccgttattt tgatgacggc atggggaagt atccagcttg ccgtgcaggg tatgcaggcc
    13681 ggcgcattcg atttcataac caagccttgg aacaatgctg ctcttttgca gcgcatcgag
    13741 acggcccttg agcttacggc cgccccgaaa gaggtgccgg aagagcagac taccgcattg
    13801 aatcgcagcc atattatagg taagtccaaa gggctgatgg aagtgctgaa cacagtggct
    13861 cgcatagccc gtaccaatgc ttcggtgctg attacgggcg aaagcggaac gggcaaggag
    13921 ctgattgccg aagccatcca tatcaacagc caacgcgtga agcagccctt tgtcaaggtg
    13981 aaccttggtg gcatctcgca gagcttgttc gagagcgaga tgttcggcca taagaaaggg
    14041 gcgtttaccg atgccagcgc cgaccgtata gggcgttttg aaatggcaaa taaaggtact
    14101 atcttcctcg acgagattgg tgacctcgac ccttcctgcc aggtgaaact gctgcgcgtg
    14161 cttcaagacc agacattcga agtgctgggc gatagccgtc cccgcaaagt cgatgtacgc
    14221 gttgtgtccg ccactaatgc agacctccgc aagatggtgt ccgaacgtac tttccgtgaa
    14281 gacctttttt accgtatcaa cctgattacc gtaaaactgc cctccttgcg ggagcgccgt
    14341 gaagatattc ctttgctggc acgtcacttt gccgaccgtc aggcagaggt gaacggcttg
    14401 ccgcgtacgg atttctcggc cgacgctctg aatttccttt cccgcctgcc ttatccgggc
    14461 aacattcgtg agttgaagaa tctggtggag cgtaccattt tggtcagcgg caagccggtg
    14521 ctggatgcca cggatttcga tgcccaatat ctgcgtcacg acgaaccggc caaagctgcc
    14581 gaaggtactt cttttgcagg tatgaccttg gatgaaatag agcggcagac tatcttgcag
    14641 gcgttggaac agcataaagg gaatctcagt caagtggcag tgtcattagg catcagccgc
    14701 gctgcgcttt acagacgttt ggaaaaatat aatattcaag tcccgtgcgc ataaaattct
    14761 ttttcttcat acttgtcctt tttctgctcg gtctgggtgg aatgctggta tatctgctga
    14821 gtggaaagcc ttctttgtat ctgtacgtgt tggaggggct catcgggttt atccttatct
    14881 atctgatagt attctataat aagatagtga agccgatgaa caccataggc agcggtatgg
    14941 agttgttgcg cgagcaggat ttcagtagcc gtctcagccg ggtagggcag tacgaagcag
    15001 accgcattgt gaatatcttt aaccgaatga tggagcagct caagaatgaa cggttgcgca
    15061 tgcgcgagca gaatcacttc ttggatttgt tgattcaggc atctccaatg ggggttatta
    15121 tcctgacaat ggacgatgaa gtgtcgcaac tgaatccgat ggcggtaaag atgctcggtg
    15181 tccgtatgga ggaggcgatg gcaaagcggc tggaccagat ggactccccg ttggctgccg
    15241 aactttcgtc cattcccaaa gacgagacgg cagtggtccg tctcaatgat gcgaatattt
    15301 ataaatgcac ccattcttct tttattgaca gagggttcaa acatcctttt ttcttgatag
    15361 agcgtatgac ggaagaagtg atgcgtgccg agaaacgtgc ctatgaaaag gtaatccgca
    15421 tgatagctca tgaagtgaac aataccactg cgggcatcac ttccacactc gatacagtgg
    15481 agcaggcact ttctacagaa gatgatatgg aggacatctg cgacgtgatg cgcgtttgta
    15541 cggagcgttg tttctcgatg agccgtttca ttacccgttt tgcagatgtg gtaaagatac
    15601 c
//
