LOCUS       gnlProkkaNIMHJIOL_110   9876 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NIMHJIOL_110.
ACCESSION   gnlProkkaNIMHJIOL_110
VERSION     gnlProkkaNIMHJIOL_110
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:19:36
            Original ID  :: gnl|Prokka|NIMHJIOL_110
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9876
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9876
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[5638:6862]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5639..6862
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..9876
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9876
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(2..64)
                     /locus_tag="ctg110_1"
                     /transl_table=11
                     /translation="MKKEDLRIVYMGTPDFAVEAL"
     CDS             complement(99..1892)
                     /locus_tag="ctg110_2"
                     /transl_table=11
                     /translation="MKGEKLSLLQRCIKWREANIKEKQFILILSFLVGIFTAFAALILK
                     FFIHQIQNFLTNNFNATEANYLYLVYPVVGIFLAGWFVRNIVKDDISHGVTKILYAISR
                     RQGRIKRHNIWSSTIASAITIGFGGSVGAEAPIVLTGSAIGSNLGSVFKMEHRTLMLLV
                     GCGAAGAIAGIFKAPIAGLVFTLEVLMIDLTMSSLLPLLISAVTAATVSYIVTGTEAMF
                     KFHLDQAFELERIPFVILLGIFCGLISLYFTRAMNSVEGVFGKLNNPYKKLAFGGVMLS
                     VLIFLFPPLYGEGYDTINLLLNGTSAEEWDTVMNNSMFYGYGNLLLVYLMLIILLKVFA
                     SSATNGGGGCGGIFAPSLYLGCIAGFVFSHFSNDFAFSAYLPEKNFALMGMAGVMSGVM
                     HAPLTGVFLIAELTGGYDLFLPLMIVSVSSYLTIIAFEPHSIYSMRLAKKGQLLTHHKD
                     KAVLTLMKMENVVEKDFVVVHPEMDLGELVKAIAASHRNVFPVTDKKTGELLGIVLLDD
                     IRNIMFRQELYHRFTVNKLMISAPAKIFDTDGMEQVMQTFDDTKAWNLPVVDEEGRYQG
                     FVSKSKIFNSYRQVLVHFSED"
     CDS             complement(1893..2501)
                     /locus_tag="ctg110_3"
                     /transl_table=11
                     /translation="MCYFCVLFLTEINQEMIEDIKKACQVMNEGGVILYPTDTVWGIGC
                     DATNEEAVRRVYEIKKRADSKAMLVLVDSPVKVDFYVQDVPDVAWDLIEVADKPLTIIY
                     SGARNLAPNLLAEDGSVGIRVTNEDFSRRLCQQFRKAIVSTSANVSGQPGAANFSEISD
                     EIKSAVDYIVGFRQDDMNKPKPSSIIKLEKGGVIKIIRE"
     CDS             2771..3202
                     /locus_tag="ctg110_4"
                     /transl_table=11
                     /translation="MEEIVFHHTLPIQLRFNDVDKFGHVNNTVYFSFYDLGKTEYFASV
                     CPGVDWEKIGIVVVHIEADFVKQIFASDHIAVQTAVSKIGTKSFHLIQRVIDTETNEVK
                     CICKSVMVTFDLERHESMPLTEEWIEAICKYEERDLQKA"
     CDS             3359..4882
                     /locus_tag="ctg110_5"
                     /transl_table=11
                     /translation="MIADKSINLDTLYKVLFDNEKLELSKECIRKVEESFDFLQSFSSD
                     KIIYGINTGFGPMAQYRIEDQSLIELQYNIIRSHSTGAGKPLPELYVKAAMIARLYTFL
                     QGKSGVHMELVSLLCEFINRGIYPFIPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGK
                     LRDAATVLEENGLQPFSMRIREGLSVTNGTSVMTGIGIVNLIYAKKLLRWSVAASVMMN
                     EIAASYDDFMAQALNEAKHHKGQQEIAAMMREWVAGSKCVLQRENELYNQVHKEKIFEH
                     KVQPYYSLRCVPQILGPIYDELKNAEEVLINEINSACDNPIVDPDTQNIYHGGNFHGDY
                     ISFEMDKLKIAVTKLTMLCERQINYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATS
                     TTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENSYQVMAIQFMGMAQAI
                     DYLKIQDRLSPKSRQVYEEIRSFFPVFTNDTPKYKEIERMMDYLKKENK"
     CDS             4884..5612
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 1.3e-16. Score:
                     52.9. Matches aSDomain: nrpspksdomains_ctg110_6_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     213.3; E-value: 6.4e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg110_6"
                     /sec_met_domain="adh_short (E-value: 3.3e-36, bitscore:
                     114.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQL
                     VQEKGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEE
                     WNKVLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTAEEVADLVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        4893..5390
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg110_6_PKS_KR.1"
                     /evalue="1.30E-16"
                     /label="ctg110_6_PKS_KR.1"
                     /locus_tag="ctg110_6"
                     /protein_end="169"
                     /protein_start="3"
                     /score="52.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQLVQE
                     KGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEEWNK
                     VLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       4896..4958
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg110_6_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg110_6"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSCKLAEMG"
     CDS             5639..6862
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-405). E-value:
                     2.2e-53. Score: 173.5. Matches aSDomain:
                     nrpspksdomains_ctg110_7_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 295.4; E-value:
                     1.2e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_7"
                     /sec_met_domain="APE_KS1 (E-value: 1.7e-160, bitscore:
                     523.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSILMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRQIKE"
     aSDomain        5834..6853
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg110_7_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.20E-53"
                     /label="ctg110_7_PKS_KS.1"
                     /locus_tag="ctg110_7"
                     /protein_end="405"
                     /protein_start="65"
                     /score="173.5"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     SILMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRQI
                     "
     CDS             6884..7135
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg110_8_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg110_8"
                     /sec_met_domain="PP-binding (E-value: 8.1e-15, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        6905..7108
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg110_8_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg110_8_PP-binding.1"
                     /locus_tag="ctg110_8"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             7138..8073
                     /locus_tag="ctg110_9"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYLFLSLVVLYFIPFA
                     PKATKSTWFYARHILKYNRIRSLKMLLLNYYRLGQILIDKVAIGNGKVNQYQFKFEQYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDR
                     EFKIIPVNEDNLTHVFRITEAINQKEYVCFQGDRYLNKEKLLPGILLGQKAPFPAGPFL
                     LASRMKVPVVFYFAMREPGRTYRFHFIIAEPVVRTKEKKAEMALLEQYTVALEQILKRY
                     PEQWFNYYPFWEPAGKQSPDLKEKQKDATE"
     CDS             8060..9130
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 126.4; E-value:
                     2.4e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg110_10"
                     /transl_table=11
                     /translation="MQQNKYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERKGMTQEEISKACGLPSYGAQVLLEASLTIGTVLLREGRYCLAKAGWFLLNDKMVR
                     VNMDFNHDVNYQGMFHLEEAITNGRPEGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDTVEVTIMDLPQQLEMMRQQ
                     TKELPGATRIHGHGANLLDPEVPFPTRFDAIWMSQFLDCFSEEEVTSILTRAARSMNRE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMQRCIEAAGLEIEEI
                     HDHLGMGHSIVQCRLK"
     CDS             9127..9561
                     /locus_tag="ctg110_11"
                     /transl_table=11
                     /translation="MNREAVIQGEGILNLIPQRPPIVMVDSFFGFEENRSYSGLTVTTD
                     NLFCEAGRLQEPGIIEHIAQSAAARIGFIYTRQGEKVPLGFIGSVDKLKIYNLPEAGMK
                     LFTEITVVQEVFDITLISAQVKTEEELIAECKMKIFIKKE"
     CDS             9558..9875
                     /locus_tag="ctg110_12"
                     /transl_table=11
                     /translation="MKRKTNQQIAALTNRTTFRVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIIETRYIACEAAKIKFEYVI
                     YR"
ORIGIN
        1 gcagggcctc taccgcaaaa tcgggagtcc ccatatatac tattcttaag tcctctttct
       61 tcatcatttt aaatatgtta tcattactta ggcacggatt agtcttcaga aaaatgtacc
      121 agcacttgcc gatacgaatt aaatatcttt gatttagaga caaatccctg atagcggcct
      181 tcctcatcca ctaccggaag attccaggct ttcgtatcgt caaatgtttg cataacctgc
      241 tccattccat ccgtatcgaa gattttggca ggagcagata tcatcaattt attaacagtg
      301 aaacgatgat aaagttcttg tcggaacatg atgttgcgaa tatcgtcgag caatacaatt
      361 cccaacaatt cacccgtttt cttatctgtc accggaaaga catttctatg ggaagctgca
      421 attgctttca ccagttcgcc caagtccatt tccgggtgta cgacaacgaa atctttctcc
      481 accacgtttt ccattttcat cagcgtcaac acagctttat ccttgtgatg tgtcagcaat
      541 tgtcccttct tagccaaacg catcgaatag atactatgag gctcgaaagc aataattgtc
      601 agatatgaac ttacagatac aatcatcaac ggaagaaata aatcatatcc acctgtcagc
      661 tcggctatca ggaacacccc tgtcaatgga gcatgcatga caccactcat tactcccgcc
      721 attcccatca atgcgaaatt cttctccggc aaataagcgg agaaagcaaa gtcattgcta
      781 aaatgagaga aaacaaaacc ggcaatacat cccaaataaa gcgaaggagc aaagatacca
      841 ccacaaccac cgccaccgtt tgttgcactg gaagcaaaca ctttcaataa gataatcagc
      901 atcagataaa ccagcaacaa attgccatag ccataaaaca tagagttgtt catgaccgta
      961 tcccactctt cggcagacgt tccattcaac aaaagattaa tcgtatcata tccttcacca
     1021 taaagaggcg ggaaaaggaa aatcaataca ctcaacatca caccaccaaa cgccagtttc
     1081 ttgtaagggt tattgagttt gccaaataca ccttctaccg aattcatggc acgtgtgaag
     1141 tacaacgaaa tcagcccaca aaaaattccc agcaagataa cgaaaggaat acgctccagt
     1201 tcgaatgcct gatcgaggtg gaacttaaac atagcctccg taccagtgac tatgtacgaa
     1261 acagttgcag ctgtcacagc agaaatcagc aggggaagca aagaagacat ggttaagtca
     1321 atcatcagca cttccaaggt aaataccagt cccgcaatcg gagctttaaa aataccggca
     1381 atggcacctg ccgcaccaca acctacgagc agcatcaacg tgcgatgctc catcttaaac
     1441 acgctcccga gattggaacc gattgccgaa cctgtcagta caattggtgc ctctgctccg
     1501 accgatccac caaatccgat ggttatggca ctggcgatag tagacgacca gatattgtgt
     1561 cgcttgatac gtccctgcct acgggagatg gcatataaaa tcttggtgac cccatgactg
     1621 atgtcatcct ttacaatatt acgcacaaac caacctgcaa ggaaaatacc gactaccgga
     1681 tataccaaat acaggtagtt agcttctgtt gcattgaaat tattagtcag gaaattctgt
     1741 atctgatgga taaagaattt caatattaac gcagcaaacg cagtgaagat tccgaccagg
     1801 aaacttaata tcaggataaa ttgcttctcc tttatgttcg cttcccgcca tttgatacaa
     1861 cgctgcaata aactaagttt ttctcctttc atttattcgc gaattatctt tatcactcca
     1921 cctttttcca acttaataat acttgagggt ttcggcttat tcatatcatc ctgacgaaag
     1981 ccaactatat aatctaccgc cgatttgatt tcatcactga tttcactaaa attagcagca
     2041 cccggctgcc cgctgacatt agccgaagta gaaacaattg ctttacggaa ctgctgacag
     2101 agtcttctgg aaaaatcttc attcgtcaca cgaatcccta cactgccatc ttcggccagc
     2161 agattaggtg ctaaatttcg tgctccggaa taaataatcg tcaacggctt gtcggcaact
     2221 tcaatcaaat cccatgctac atcaggtaca tcctgtacat aaaaatccac tttaaccgga
     2281 gaatccacca acaccaacat agctttgcta tcagcacgtt tcttgatctc atatacccgg
     2341 cgtacagcct cttcattagt cgcgtcacag cctatacccc atacggtatc agtgggataa
     2401 aggatcactc ctccttcatt catcacctga caggcttttt taatatcttc tatcatttct
     2461 tgattaattt ccgttaagaa caagacgcaa aaataacaca tttattccat ttagtgaaat
     2521 ctatcctgac gtttttaaat taccctttaa aatcaactgt tggcagacaa taatttaact
     2581 attacattat tacaagcgtg tttccctaac aggacaaaca tcccaaaact tcgttttaaa
     2641 cgattattaa cgaaaatctt ccttatctcc gaaagcagaa tcattagaaa tctctatctt
     2701 tgcctcaatt tcaagcaaga aagcaaaagt gccatttttg tgtcgaattt aaaacgttta
     2761 agagaaaaca atggaagaaa tcgtatttca tcacacatta cctatccaat tgcgattcaa
     2821 tgatgtagac aaatttggtc acgtcaacaa cacagtttac ttctcctttt acgacttagg
     2881 aaagactgaa tacttcgctt cagtatgccc cggagtagat tgggaaaaga tcgggattgt
     2941 cgttgtccat atcgaagcgg atttcgtcaa acagatattc gcatccgatc atatcgccgt
     3001 acagactgct gtttctaaga taggcaccaa aagctttcac ctgatccagc gggttatcga
     3061 cacagaaacg aatgaagtaa aatgtatctg caagtctgtt atggttactt tcgatcttga
     3121 aagacatgaa tccatgccac tgacagaaga atggatagag gcgatctgca aatatgaaga
     3181 acgggacttg caaaaagcat agatagattt tttgaaaaag ccccctcacg aatgagaaac
     3241 aaaacaagca aaaccaattc tccggaaaaa gttttattct aattcatgtc cgctatataa
     3301 cagaaattgc ctatttttgt accttaatta ataaggcata aaatatctag tacagaaaat
     3361 gatagctgac aaaagtataa atttagatac cctttataaa gtattgtttg ataatgagaa
     3421 gctggaactc tctaaagaat gcatccgaaa agtagaggaa agcttcgatt tcctacaatc
     3481 tttttccagc gataagatta tttatggtat caatacgggg ttcggcccaa tggcacaata
     3541 ccggatagaa gatcagtcac tgatcgaact tcagtacaat atcattcgaa gccattccac
     3601 cggtgccggt aaaccacttc ccgaacttta tgtaaaagca gctatgattg cccgcctgta
     3661 cacttttcta caggggaaat caggagtaca catggagctg gtatctcttc tctgtgaatt
     3721 tatcaaccgt ggaatttatc cgttcatacc cgaacatgga agtgtaggtg ccagcggcga
     3781 tctcgtgcaa ctggcccata ttgccctgac attaatagga gaaggggaag ttttttatca
     3841 ggggaaattg cgtgatgccg ctactgtgct tgaggaaaac ggtctgcaac ctttttcaat
     3901 gcgcatccgc gaaggattat ccgtcacaaa cggtacttct gtgatgacag gaatcggtat
     3961 cgtcaatctg atttatgcca aaaagctgct ccgttggtcg gtagccgctt ctgtcatgat
     4021 gaatgagatt gccgcctctt atgatgattt catggcacag gcattaaacg aggccaagca
     4081 tcacaaaggg caacaagaga tagccgctat gatgagagaa tgggtcgcgg gcagcaaatg
     4141 cgtacttcaa agagagaatg agctatacaa ccaggtgcac aaagaaaaaa tcttcgagca
     4201 caaagtacag ccctattatt ccttgcgatg tgttccgcaa atcctcggtc ccatctatga
     4261 tgagctgaaa aatgcggaag aagtattgat taacgaaata aattccgcct gcgacaatcc
     4321 gattgtcgat ccggacacac aaaatattta tcatggcggt aacttccacg gagattacat
     4381 ctctttcgaa atggataaac tgaaaatcgc cgtaaccaaa ctgaccatgc tttgcgaaag
     4441 acagatcaat tatctgttcc acgaccgtat caatggcatc ctgcctcctt ttgtaaactt
     4501 gggagtgctt ggattgaact acggtttgca ggcttcgcaa ttcacagcaa catccactac
     4561 agccgaatgt cagacattgt cgaatccgat gtatgtgcac agtattccta acaacaacga
     4621 taatcaggat attgtcagca tgggaaccaa ctcggctcta ttagcaaaaa cagtcataga
     4681 gaattcttat caggtaatgg ctattcaatt tatgggaatg gcgcaagcca tcgactacct
     4741 gaaaatacag gatcgtctaa gtcccaaaag ccgtcaggtg tatgaagaaa tacgtagttt
     4801 cttccctgta tttaccaatg acacacctaa atataaagag atagaaagaa tgatggacta
     4861 tctcaaaaaa gaaaataaat aaaatgaaat acgcattagt aaccggagga agtcgaggta
     4921 tcggccgtgc tgtcagttgc aaactggcgg aaatgggcta ctttatactg attaattatc
     4981 agagtaacga cgcagaagcg gaaaaaacgt tgcagttagt gcaggaaaaa ggaagtaacg
     5041 gagaaatcat gaagttcgat gtgacagacc ctgccgctat tgcccttgcc ttgaacaact
     5101 gggcgtcaca acatcctgac gaatacatcg aagtactgat taacaatgcg ggcatccgca
     5161 aagacaacct gatgctttgg atgacaggag aagaatggaa caaagtgctc gatatcagtc
     5221 tgaacggatt cttttatgtg acacaacctt tattgaagaa tatgctggtc aaacgttatg
     5281 gacgtattgt caatatcgta tccttgtcag gtattcaggg aatgcccgga caagccaatt
     5341 attccgcagc caaaggtggc gtaatagctg ctaccaaagc actggcacaa gaagtggcca
     5401 agaaaaaggt aacagtcaac gcagttgctc ctggatttat ccgcacggat atgacggaag
     5461 ggattgatga gaacgaatgg aaaaaacaca ttcctgcagg acgtttcggt actgcggaag
     5521 aggttgccga tctcgtcggt tttctggcat ctccggcctc atcctatatc acaggagagg
     5581 tgatttccat caacggagga ctatatactt aaaacaaaag catagaatag acaaaataat
     5641 gaaaagagtt gttatcacgg gaatgggaat ttactcttgc atcggcaaga acctggatga
     5701 agtaaaagac tcactataca atgggaaatc ggggattggc atagatccgg tacggaaaga
     5761 actgggctat ttttctgcat taacgggcat attggaacgt cccgacttga agaaactatt
     5821 agatcgtcgt aaacgtctct gcctgccgga acagggagag tatgcttatc tcgctacttt
     5881 ggaggctttc cgcaacgccg gtattgacga tgcttttctc gaagctaatg aagtgggtat
     5941 cttgtatggc aatgatagta gtgccgctcc tgttattaat gcagtggaca tcattcgtga
     6001 aaagaaaaac acagcgttgg taggttccgg ttctattttc cagtcgatga attctaccgt
     6061 gacaatgaac ctgtcggtta tcttcaagct tagaggagtt aacttcacca ttgccggagc
     6121 ttgtgcaagt ggttctcatg ctattggcat ggggtatctg ctcattaaat caggattgca
     6181 ggattgtatt ctttgcggtg gcgcacaaga agtaaatcct tatgcggtcg gcagtttcga
     6241 cgggctaagc gcattttcca cccaggaagc agagcccgag aaagcctcca aaccttttga
     6301 taaacgacgt gacggactga ttccgagtgg aggagccgcc agtctggtat tagagagcta
     6361 tgaatcggca gtaaaaaggg gagctcccat tttggccgaa gttatcggtt acggtttctc
     6421 ttccaatgga gatcatatct ccgtaccgaa cgtggacggt ccgaaacgtt ctcttcagat
     6481 ggccatcaaa gatgcgggta ttgcactcga acaaatcagt tatatcaacg cacacgccac
     6541 ttccactccg gtaggcgacc tgaacgaagc gaaagccatt gcggaagtat ttgaaggaca
     6601 tcacccgtat gtcacttcca cgaagtctat gaccggacat gaaatgtgga tggcaggtgc
     6661 cagtgaagtg atttactcca tcctcatgat gaataacggt ttcatcgctc ccaacctcaa
     6721 tttcgaggaa gcggacgagg cttccgcaca gttgaatata cctacccaac gggtaaatct
     6781 ggaatttgat acgttccttt ccaactcgtt tggattcgga ggaaccaatt ccaccctgat
     6841 tatacgccaa atcaaagaat aaattactaa agaaaacaga tatatgacaa acgaagaaat
     6901 catcgagaaa ataagaacaa ctctggcaga agagtttgaa gtagacatcg acgtcatcca
     6961 gccggatgcg ccgttaatgg aaactcttga actggacagt ctggacttgg tcgacatggt
     7021 ggtactggta gaaaagaatt tcggtttcaa cgtaaccgga caagactttg caggtatcaa
     7081 aaccttccag gacttctacg atctcgttat cacccgtatg caggaagcca agtaaatatg
     7141 tcgacgtgga aaggcaaaac ccggggagga acgttcggat acttattctt tatttacctg
     7201 attaagtatc tgggcattac tgccgcttat ctttttctaa gcctggtagt gctctacttc
     7261 ataccgtttg ctccgaaagc aaccaaaagc acctggtttt atgcccgtca cattctgaaa
     7321 tacaatagga tacgttcttt gaaaatgtta ctactcaact attaccgatt aggacaaatc
     7381 ctgattgaca aggtagccat cggtaatgga aaagtaaatc aatatcagtt caaattcgag
     7441 cagtatccgg agtttctgca actgctgaac agtgaacagg gagtgattat gattggcgcc
     7501 catgtgggaa actgggaaat aggcgttcct ttctttgatg attacggaaa gaaaatcaat
     7561 atcgtgatgt acgatgccga acatcgtaga atcaaagaga tcctggagaa aaacggtcag
     7621 gacagggaat ttaagattat ccctgtcaat gaagacaacc tgacacacgt tttccgcata
     7681 accgaggcga tcaaccaaaa agaatatgta tgtttccaag gcgaccgtta tctgaacaaa
     7741 gagaaacttc tgccaggaat tttactggga cagaaagctc cttttcctgc cggtcctttc
     7801 ctgctcgctt cgcgaatgaa agttccggtg gtattctact ttgcaatgag ggaaccggga
     7861 agaacttacc gttttcattt tataatagcg gaaccggtag tacgaacaaa agaaaagaaa
     7921 gcggagatgg ctctgctcga acaatatact gttgctttgg aacagatact aaaacgctat
     7981 ccggaacaat ggttcaatta ttatccattc tgggaacctg ccggaaagca gtcaccggat
     8041 ttaaaagaga aacaaaaaga tgcaacagaa taaatatgac aaagagccgt tgacagcggt
     8101 agaggcacaa cgcctggcac aagaaatagc ttttgggcct attgtttttc aggtatcacg
     8161 ccttatgctt aaattcggaa ttttccagtt attggccgac gagcgcaaag gtatgacgca
     8221 agaagaaatc agcaaagctt gtgggctgcc ctcttatggc gcacaagtat tgttggaggc
     8281 atcattgact atcggcaccg tattgttgcg tgaagggcga tactgccttg cgaaagccgg
     8341 ctggtttctg ctcaatgaca aaatggtacg tgtcaatatg gacttcaacc atgatgtcaa
     8401 ctatcaggga atgtttcatc tggaagaagc catcaccaac ggacgtcctg aaggactgaa
     8461 agtattcggt gaatggagta ctatctatga agggttgtca agtctgcctt cacaagtaca
     8521 aaagagctgg ttcggtttcg atcattatta ctcggattgt tcgttcgatg aagcactggc
     8581 aattgtcttc gcccgccatc ccaagacttt attggatgtg ggaggcaata ccggccgctg
     8641 ggcgaccaaa tgcgtaagct acgacgacac agtggaagta accatcatgg atcttccgca
     8701 acaattggag atgatgcgtc aacaaactaa agaactgccc ggagctacac gtatccacgg
     8761 tcatggtgcc aatctgcttg atccggaggt gcctttcccg acaaggttcg atgctatttg
     8821 gatgagccag ttcctcgatt gtttctcgga agaagaagtt accagcatat tgacccgtgc
     8881 agcccgttct atgaaccgag agagccgcct gtatattatg gagactttct ggaaccgaca
     8941 gaaatttgac acagccgctt attgcctgac acaaatcagt ctctatttta cagcgatggc
     9001 aaacggaaac agcaagatgt atcattcgga cgatatgcaa cgatgcatcg aagcagcagg
     9061 attggaaatc gaagagatac atgaccattt aggaatggga cacagcatcg tacaatgcag
     9121 attgaaatga acagagaagc cgtcatacaa ggagaaggaa tactcaacct gattccacag
     9181 cgtccgccaa tcgttatggt ggacagtttc ttcggatttg aagaaaaccg ttcatattcc
     9241 ggactgactg tcactaccga caatttattt tgtgaggcag gcagactgca agagccggga
     9301 attattgagc atatcgcaca atcagcggct gcacgtatcg ggtttattta tacccggcag
     9361 ggtgaaaaag ttccgttagg ttttatcggt tcggtagaca aacttaaaat ctacaatttg
     9421 ccggaagccg gaatgaaatt atttacagag attaccgtcg tacaagaggt attcgatatt
     9481 acgcttattt cggcacaagt gaaaacggaa gaagagctga ttgctgaatg taagatgaaa
     9541 atatttatca aaaaagaatg aaacggaaaa caaatcaaca gattgcagct ttgactaacc
     9601 ggactacttt cagagtacgg ttcagcgaaa ttgactccat gcagattgta tggcatggcg
     9661 agtacgtgcg ctactttgaa gatgggcggg aagctttcgg caaacagtat ggtttggatt
     9721 atatgagcat ttaccgggaa ggctacatgg ttcccatcgt agatttaacc tgccagttca
     9781 agcaatcatt gtcctttggt gaagaagcga ttatcgaaac acgctatatt gcctgtgagg
     9841 cagccaagat aaaattcgaa tacgttatct accggg
//
