LOCUS       c00024_gnlPro..        15534 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NIMHJIOL_24.
ACCESSION   c00024_gnlPro..
VERSION     c00024_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:09:46
            Original ID  :: gnl|Prokka|NIMHJIOL_24
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 12654
            Orig. end    :: 28188
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15534
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[22654:27197]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14543
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15534
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15534
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(477..1271)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_12"
                     /sec_met_domain="F420_oxidored (E-value: 1.7e-14, bitscore:
                     45.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYHKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQEISKDAKLYIVSLKDAALVDLLPQITEGKQNSLLVHTAGSIPMS
                     IWEGYAERYGVFYPMQTFSKQREVNFQEVPFFVEAKRPEDVELLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
     CDS             complement(1279..1614)
                     /locus_tag="ctg24_13"
                     /transl_table=11
                     /translation="MGAAKASNSKDTYLATAVTFIVIGALYLIDKLIHFSTIGLPWVMN
                     KDNMLLYASICFLIFKRDKSIGFVLLGLWLVMNISLVISLLGSLSGYLLPLTLLIVGII
                     LFWFAKR"
     CDS             complement(1617..2153)
                     /locus_tag="ctg24_14"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDQVVTLMKAALMSPSSKRSNS
                     WQFVVIDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILGIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             complement(2168..2332)
                     /locus_tag="ctg24_15"
                     /transl_table=11
                     /translation="MKLFICAKIQYILHLVEYLALFSSYRFPSDNRNEKDTFISYYARF
                     ALSLHTLIK"
     CDS             2334..2558
                     /locus_tag="ctg24_16"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIEMYGHPICHKRVHQSKKVYNRR
                     KIKAADKKLPYFFVFKIASLSSRHSDTIQ"
     CDS             complement(2647..3189)
                     /locus_tag="ctg24_17"
                     /transl_table=11
                     /translation="MIEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EVMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
     CDS             complement(3299..5323)
                     /locus_tag="ctg24_18"
                     /transl_table=11
                     /translation="MKSTIYKIAALTFAVASMSACSLDEYNPSQKTGDEILATFDGLKG
                     LQSYCYSSLYGQLFSVYDFLSVAEGGTDCWITPAGNPDYAKQVIYYDGLATNTNATNKL
                     FGQAYSMIGNCNAVVNRAELLTDGNEKDITTLVAEARCLRAFYYSILVNTYGNVTLTLE
                     ESSQDPILTPQRNSIEELYTQIIDDLKFAANNLEDTPYDNNRARVTKKTALGLLARVYA
                     QGGGEYGLTEEGVSYWQRAKEVAEDMILAYGDCLYDDVEDVWAPANNRNNKEALFIAAG
                     PDATNLENWNAGTQCNNNFTYMYPKPNTLTIYPTPDNQNYWYGRTNNNTLAPSKYLLDC
                     FDADYDKRWEVTFTTAFVQFSAVQSGGSYLFTNKKQTLDDGTKPKIGTKHGVNDNISSF
                     TILTQNIIDTYGLDAKFHNEYIYPYGDLNYTYYDGTWAPKMIAKVWPKGENSGDPSKLQ
                     EVKNPYVIPYPVAEDDDRICFYLSKERLSDAEKAKRRYYVINIDDLFDNGQYRKTDIKV
                     TNDKNMYPGFNKYNWLSEDSYSSNLQRKTGDVFIMRMAEVYLIAAEANQQLGNGGKAAE
                     YLNVLKKRAARNDASYNAMKLSNATQNDVMDEYARELCGEYQRWVLMKRHKDSFKQRLA
                     VGNPRAAENFDENKHYLRPISFNFLSQIDNAEEYGNNGY"
     CDS             complement(5348..8533)
                     /locus_tag="ctg24_19"
                     /transl_table=11
                     /translation="MILGLSLLSAPLSYSVYAEDGVSNTMVQVVTQTKTVKGTIIDESG
                     EPLIGVSIVVKGTSTGTITDFNGNFSIDLPAGRRELVISYIGYKEQTVTVTGNGPVNVK
                     MVSDTQALDEVVVVGYGTMKKRDLTGAITSVKSEDVVMNPSSNPMQALQGKVAGLDITR
                     ESGQAGSGVKMQLRGNRSFQKDSGNPLFIIDGMPGDYSTLNPNDIESIEVLKDASSTAI
                     YGSSGANGVILITTKGGKEGKAIVNFNAYVGVNGWSRTPEMRSGESYIQTLRDASVGAG
                     DGRWSSVADDKNLFTTDAEWSAHQNGQYIDWVDALLKTSVTQNYSVSVAGGTEKTKAYF
                     SLNFSNEDGQFAQDSYKLYSSKIRVDHKIKKWMKVGIDAQLSYVHQNKADSDLQTLMAS
                     NPLGSLYNEDGSINPQPVADPSSTVYNYLLNEDKSLYRNQAQNLKVYFNPYLEITPLKG
                     LTFITRAGASLGYSRSNTFTGEGSVQWYKANQTADGIKAQVKDNRSYNYKWENILTYNF
                     QIKKVHDITLTAVTSWNHNRSDVTTLYQKGVSDNKFLWHNILDGNSATSGSTSYSMSKG
                     MGYVGRLNYSYMGRYLFAASVRHDGSSRLAEGNKWDTFPAFSLGWRISDEKFMESTTNW
                     LSNLKIRFGYGVTGSTAGIDPYSSAASLDATAVNMILGGVLTPIYKFSQNIPNYLLTWE
                     KSYNTNIGIDAAFLNNRIDVSMEYYNTKTKDVIWNKALPVINGAFSPDGGPKANYTTNL
                     NMCETSNKGFELALNTRNIITKNFTWSSSVTFNHNKEKITKLSGGDSDVLNNGDTGYAL
                     ALGEAINSYYHYKLDGVWQKGEETDAAVFGAAPGDLKINIPNLVKESDGRFYKIDEETG
                     SAAVDENGNVIYYTSDNKYTPSDADYQILGHNSPDWSLGFQNNFTWKDFDLSVFVYARY
                     GQMFAYDMLTSYDPKGIRNFPTYFNYWTENNPSNDFPAANANKGLEQYTGYYALRYVDG
                     SFIKIKNITLGYSLPKSILKSAGIEKCRFYATITNPFVFAKSHLLKDYDPEMNGSLKYP
                     LTKQFVFGVNVTF"
     CDS             8827..9825
                     /locus_tag="ctg24_20"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNAFHSKELFQIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEIFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNDMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSEDDAYLWFSGGMRKTYALQYPGVLAVWKALEDARQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWNWLNKLLVKFYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_21"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2.8e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10420..11973
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_22"
                     /sec_met_domain="CT_Btheta (E-value: 4.1e-290, bitscore:
                     953.0, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             12005..12925
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_23"
                     /sec_met_domain="OAD_gamma (E-value: 1.4e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILINNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGKKLLDQIVVPAGALGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             12950..13381
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_24"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.5e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             13383..14543
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_25"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-153, bitscore:
                     501.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLVFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFVIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(14728..15534)
                     /locus_tag="ctg24_26"
                     /transl_table=11
                     /translation="LLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKSCIDSGFS
                     SVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSADHHTYTDPEEV
                     IDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFEVLDAVMEKLPGF
                     PIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSDSRLAMTA
                     AIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAQ"
ORIGIN
        1 tccacagacc atgagctttc agtacttgct ccactacatc acgtccgcaa ccacgtccgc
       61 cgtctgcata agagatatac tttgctacgg atttcacttc cggcacggca tctttcggac
      121 aacatggaag tccacattca cgcatcactt caatatccgg aacatcatcg cccatataga
      181 gaatttcatc atcggtcagt ccgtatttat cacgaaaatc acgatagtcg tgtatcttga
      241 cggcggatcc catatacaga tccttcactc ccagtccttc aaaacggata cgcactgctt
      301 ctgtacggcc accggtgatg atggctatgt gaagtccttt tttcacagcc aactggatag
      361 cgtacccatc tttgatattc acagtacgca tcggctctcc ggaaggatgc aaaggtacgg
      421 ttgtcgaact caatactccg tctacgtcaa aagctaaagc cttgatacgg gataaatcat
      481 agttgatggt gctcatggat acttttgctc attagtttat atatttcctg caatgccgga
      541 gaatctacca acatggcaag atgattgttc atcacattct catcgtaacg gacagcgggt
      601 ccggtctgtg catcacgcgg tgccagttcg tgtactttac gtgccgtttc atctatcagc
      661 ggaagcatga catcgaaagg caagttgtat ttttcaagca aatcagcagc taatgcatac
      721 atgtgatttg tgaaattgca gataaaaaca gcagccaaat gaaggctttt acgctgctcg
      781 gaagaagctt cgtaaacttt ctccgaaaga gtggcggcaa cagctttcaa gagttctaca
      841 tcttccggtc ttttcgcttc aacaaagaaa ggcacttcct gaaaattgac ttcacgttgt
      901 ttgctgaatg tctgcatcgg ataaaatact ccataccgtt ctgcataccc ttcccaaata
      961 ctcatcggga tacttcccgc ggtatgcacc aacaaagaat tttgttttcc ttctgttatc
     1021 tgcggcaaca aatctactaa agcggcatcc ttcaaagata cgatatacaa tttagcatct
     1081 ttggagattt cctgtaaatc tgttgtatat tcagcttcaa ctttctcggc taaagtacga
     1141 gcagattcca tggtccggct atatacctgc acaatacgga agcctttatg atagagagcc
     1201 ttcgccagat tagtagccag gttacctgcg ccgataaaca caatcggtgt atcttctata
     1261 cttctcttca ttatttcctt accgttttgc aaaccagaat aaaatgatgc cgacaatgag
     1321 caaagtcaat ggcagcagat acccggataa cgaacccagc aatgatatta ccagactgat
     1381 attcatcacc agccaaagac caagtaacac aaaaccaatt gatttatcgc gtttgaaaat
     1441 aagaaaacag atcgaagcat acaataacat attgtcttta ttcatcaccc aaggtagtcc
     1501 aatagtggag aaatgaatca gtttatcaat cagataaagt gctccgataa cgataaaggt
     1561 aacagcagta gccaaataag tatctttgct gttactcgct ttagcagctc ccatatttat
     1621 tttcctccga atttatttat gtgaattttc tcccattgaa gatgttcttc gttgaaaggt
     1681 ttacgttcca tccctttatg tccgatagca ataacggaaa gaatttgaag ttgcagagga
     1741 atacccaaga ttccatgaac aaattcatcg gaaggcattc cggtagcagt gaaacgttcg
     1801 cggacctgca cccagcagct tcccaagccg agatcttcgg cctgcaactg tatcatgata
     1861 gaagcaatag aagcatcttc aatccaaaca tcactggcca acggatcggc cattaccaca
     1921 attgccaaag cagcgtcggc aataaatgaa gaagcctgtt ccttacaatg agacaattct
     1981 ttcaatacct ctttatcatc aatcactaca aactgccaac tattactacg tttggaagaa
     2041 ggagacatca aagctgcttt catcaatgta actacctgat cttgtgtcaa ctcttcatcg
     2101 gtgaacttcc gcatactacg acggttcttt attaattcac tgaaattttc catattattt
     2161 tccggtttca tttgattaat gtatgcaaag ataatgcaaa ccgagcgtaa taggaaataa
     2221 aagtatcttt ttcatttcta ttgtcagaag ggaatctata agatgaaaag agtgccaaat
     2281 actccactaa atgaagaata tattgtatct ttgcacagat aaataatttc attatgaaaa
     2341 agcgaattac acaagacgat tacattaaag cgaatcgtaa agctagccgt gaggcagaaa
     2401 ttgagatgta cggacaccct atttgtcaca aacgagtgca ccagtcaaag aaagtatata
     2461 accgcagaaa gataaaggca gccgataaaa agctgcctta tttttttgtc ttcaaaatag
     2521 cgtcactatc ctccagacat agcgacacta tacaatagga atggcgtcac tatcatgata
     2581 ggatagcgtc actatattta ggggattaaa aagaagttta tctatttacc taatctatct
     2641 aattatctat acaatccgag ttaattcccc ggtcgtagaa tcaataataa acccgtagac
     2701 tgtcacatct gaagggatca aaggatgacg cacgataaaa tccaccgttc ctctcaccga
     2761 cttttccgta tcttcgaagc catccagcca cgaatgaaag tcaactccgc agaaacgcat
     2821 catgtcaata taatccggat tgatcccgcg tgctttcatt ttttcgagca ttacttcact
     2881 gtgcatgtgg caagctccac agtcagaatg agcaatcacc attatttcct ctacccccaa
     2941 ctcaaaaata gctacaagta aactacgtat cacgctaccg aaaggatggg aaataacgcc
     3001 acctgcattt tttatcattt ttacatcgcc attcttaatt cctaatgcgg ctggaagcaa
     3061 agctgtcagt cgggtgtcca tacaggaaag aatagctatt ttcttatcgg gatatttatt
     3121 ggtaatatac gattcgtatc ccttgttctc aacaaattgc ttgttgtaag ctaaaatttc
     3181 ttctatcata gttccgctta aattataaag ctctgtttga tgatacaaag atatagaaaa
     3241 aagggacata tcatcacgac atatcccctc tttaatctaa atttaatctg taagagtact
     3301 aatacccatt gtttccatat tcttctgcat tatcaatctg actcaagaag ttaaaagaaa
     3361 tcggacgcaa ataatgcttg ttttcatcaa aattttcagc tgcacgagga ttaccaacag
     3421 caagacgttg tttaaaagaa tctttgtgac gcttcatcaa tacccaacgt tgatattctc
     3481 cacataattc acgagcatat tcgtccataa catcattctg tgtagcatta ctcaatttca
     3541 tagcattgta agatgcatca ttgcgagcgg cacgcttttt cagtacattt aaatattcag
     3601 cagcttttcc gccatttcct aattgttggt tagcttcagc tgcaatcaga tatacttcag
     3661 ccatacgcat aatgaacaca tcacctgtct tacgttgcaa attgctacta tatgaatctt
     3721 ccgacaacca attgtatttg ttgaaaccag ggtacatatt tttgtcatta gtaactttta
     3781 tatctgtttt acgatattgt ccgttatcaa acaaatcatc aatattgatt acataatatc
     3841 tacgtttcgc tttctccgca tccgaaagtc tttcctttga taagtagaaa cagattctat
     3901 catcatcttc agctacaggg taaggtatca cataggggtt cttcacttcc tgcaatttgg
     3961 aaggatcacc gctattttca cctttcggcc aaaccttggc tatcattttg ggcgcccaag
     4021 ttccatcata atatgtataa ttcaaatcac cataaggata aatatactca ttatggaatt
     4081 ttgcatccaa tccataagta tcgattatat tttgagtaag aattgtaaat gaactaatat
     4141 tatcatttac gccatgtttt gttccaattt ttggttttgt accatcatcc aatgtctgct
     4201 tcttattagt aaataaataa ctacctcctg actgtacggc agaaaactgt acaaaagccg
     4261 tagtaaaggt tacttcccac cgcttatcat aatcagcatc aaaacaatcc agcaaatatt
     4321 tggaaggtgc caacgtatta ttattagtac gtccatacca ataattttga ttatccggag
     4381 taggataaat agtgagagta tttggctttg gatacatata agtaaagttg ttattacatt
     4441 gtgttccagc attccagttc tccaaattcg tagcatccgg accggcagca ataaataaag
     4501 cttctttatt atttcgatta tttgccggag cccaaacatc ttccacatca tcatacagac
     4561 agtcaccata cgctaaaatc atgtcctctg ccacttcttt agcacgttgc caataagata
     4621 ctccctcttc tgtcagccca tattcgccac caccttgagc ataaacgcga gccaaaagtc
     4681 ctaacgcggt tttcttagtc acacgcgcac gattattatc ataaggagta tcttcaagat
     4741 tattggccgc aaatttcaaa tcatcaatta tctgcgtata tagttcttca atagagttac
     4801 gctgcggagt caaaatagga tcttgagacg attcttccaa tgttaacgtt acattcccat
     4861 acgtattcac caatatggaa taataaaacg cacgaagaca gcgggcttca gccactaacg
     4921 tcgttatatc tttttcattg ccatccgtta gtaattcagc cctgtttact actgcattac
     4981 aattaccgat catagaataa gcctgaccga ataatttatt tgtagcattc gtattcgtag
     5041 ctaaaccatc ataataaatc acctgcttgg cataatccgg attaccggca ggagttatcc
     5101 agcagtccgt accaccttca gccacagaca agaaatcata gacactgaat aactgcccgt
     5161 aaagtgatga ataacaataa gactgtaatc ctttaagccc atcgaacgtt gcaagaattt
     5221 catctcctgt tttttggctt ggattatact catcaagcga gcaggcagac attgaagcca
     5281 cagcgaatgt aagcgctgct attttataga ttgtactttt catttcaata ctttttttag
     5341 tgaaaaacta gaatgtaaca tttacaccaa atacaaattg tttggtcaat gggtacttca
     5401 gagaaccatt catttcggga tcatagtctt tcagcaaatg gcttttcgca aatacaaacg
     5461 gatttgtaat ggtagcatag aaacgacact tctctatacc ggctgatttt aagatagatt
     5521 tcggcagact atatcccaat gtaatgttct taatctttat aaacgaaccg tctacatagc
     5581 gtaatgcgta atatcccgta tattgttcga gacctttatt agcattggcg gcaggaaaat
     5641 catttgaagg gttgttttca gtccaataat taaaataggt cgggaagtta cgtataccct
     5701 tcgggtcata agacgtcaac atatcataag caaacatctg tccgtaacgt gcataaacaa
     5761 acacacttaa atcaaaatcc ttccaggtaa aattattctg gaatcctaaa gaccaatccg
     5821 gagagttgtg acccagaatt tgataatctg catcacttgg agtatattta ttatcagaag
     5881 tgtaataaat aacattacca ttttcatcta cagcagcact acccgtttct tcatctattt
     5941 tatagaatct accatcagat tcttttacta aattaggtat attgattttc aaatcaccag
     6001 gtgcagcacc aaataccgcc gcatcagttt cctcaccttt ttgccataca ccatccaact
     6061 tataatgata ataagagtta atagcttctc ccaatgccaa tgcataaccg gtgtcaccat
     6121 tattaagcac atctgaatct ccaccggaca atttggttat tttctcttta ttatgattga
     6181 aagttacact tgaactccag gtaaagttct ttgttataat attacgtgta ttaagagcca
     6241 actcaaaacc tttattgcta gtctcacaca tatttaaatt agtagtataa ttcgctttag
     6301 gtccgccatc cggggagaat gctccattaa taacaggaag tgccttgttc catataacat
     6361 cttttgtttt tgtattataa tattccatac tgacatcaat gcgattattt aagaatgcag
     6421 cgtcaatacc aatattcgtg ttatacgact tttcccatgt aagcaaatag ttcggaatat
     6481 tctgtgagaa tttataaatc ggcgtcagaa cacctcctaa tatcatattt acagcagtag
     6541 catccaatga tgcagcagac gaatacggat caatacccgc tgtactaccc gtaacaccat
     6601 atccgaagcg aattttcaga ttactcaacc agttagtcgt actctccata aatttttcat
     6661 cagagattct ccatcccaaa gaaaaagccg ggaaagtatc ccatttatta ccttctgcca
     6721 gtctggaaga gccgtcatgg cggacagatg cagcaaataa atacctaccc atatatgaat
     6781 agttcaaacg gccgacatat cccatcccct tagacatact ataagaagta cttcccgaag
     6841 ttgcggaatt accatcaaga atattatgcc ataagaattt attatcagaa acaccttttt
     6901 gatacaaagt agtgacatcg ctacgattgt gattccaaga tgtaactgca gtaagagtta
     6961 tatcatgcac tttcttaatc tggaaattgt aagtaagtat attttcccac ttataattat
     7021 acgaacggtt gtccttaact tgcgccttaa tgccgtctgc cgtttgattt gccttatacc
     7081 attgaacaga cccctctcct gtgaaagtgt tactacgtga atatcccaaa ctagcaccag
     7141 cacgagtaat aaaagtcagc cctttaagag gagtgatttc caagtaagga ttaaaataga
     7201 ccttaaggtt ttgagcctga ttgcggtaca aacttttatc ctcatttaaa agataattat
     7261 atactgtaga tgaaggatcg gcaacaggtt gcggattgat gcttccatct tcattataca
     7321 acgatccaag aggatttgac gccatcaaag tctgtaaatc agaatcagct ttattttgat
     7381 gtacataaga cagttgagca tcaatgccca ccttcatcca ctttttaatc ttatgatcta
     7441 cccggatttt agatgaataa agtttatagc tatcttgtgc aaactgccca tcctcattag
     7501 agaagttcag agaaaaatat gcctttgtct tttccgttcc accagccaca gaaacagaat
     7561 aattctgtgt tacactggtt ttcaacaaag catccaccca atctatatat tggccatttt
     7621 gatgtgcact ccattcagca tcagtagtaa acagattttt atcatcagca accgagctcc
     7681 aacgtccatc gccagcacca acagatgcat ctctcaaggt ttgtatataa ctttctccac
     7741 tacgcatctc cggagtcctt gaccagccgt ttacacctac gtatgcatta aaattaacaa
     7801 ttgctttgcc ttccttacca cctttagtag taattaaaat aacaccgttc gcaccacttg
     7861 aaccataaat agctgtcgaa gaagcatctt ttaaaacttc aatgctttca atatcattcg
     7921 gattcaatgt agaataatcc cccggcatac catcaattat aaataaagga tttccggaat
     7981 ccttctggaa tgaccggtta ccacgcaact gcatctttac tcccgaaccg gcctgtcccg
     8041 attcacgcgt aatatccaat cctgccacct taccttgtaa agcctgcatc ggatttgaac
     8101 ttggattcat cactacatct tcacttttta cagaagtgat agctcctgtc aaatcgcgtt
     8161 ttttcatcgt accgtaaccc acaacaacca cttcatccaa tgcctgtgtg tccgaaacca
     8221 ttttcacatt gaccggtccg ttgcctgtca ctgtcaccgt ttgttctttg taaccgatat
     8281 aagaaatgac cagttctctt cttcccgccg gaagatcgat agagaagtta ccgttaaaat
     8341 cggtaatcgt acctgtactt gttcctttca caacgataga aactccaatc agcggctccc
     8401 cgctttcatc aatgatagtt cctttcacag ttttcgtttg tgtgacaact tgcaccatag
     8461 tattagaaac tccatcttct gcatacacag aatatgacag aggggcagac aataaagaca
     8521 gccctaaaat catggaagcg cgtctatgat gattcttcca tgcttcaaca aatgcattac
     8581 atctcattcg ttctaattta aagttaatat taattctcgt tgttttgcaa aaactattcg
     8641 attataatct taattaaaga cgaatctaat tttaatacgt actcactttt cataccatat
     8701 ttctcctata aaatatattt tctccattaa atacgcaact atatattata ctttacttca
     8761 agcagctcca acaaattctt tgttttgttg ttgaataaag aataaaaagt gtaaatttgt
     8821 acctagatgc cacttaaact aaccacatat tatcatggga aggacattcc tgaattgccc
     8881 ggaaaaaacg ccttccattc caaagagtta tttcaaattt atgaagcgac tccggggtat
     8941 actcctttat taatagtagc aacagaagac ggcagacctg tggcacgcct gcttgctgcc
     9001 atccgcaaag cgaaaaagtg gcttccctcc tctttagtga aacattgcgt agtatatagc
     9061 gaaggggaat ttctggatga gtcgctttcg accaacaaag aaaaggcaga agaaatcttt
     9121 ggcgatatgc tcgaacatct cacacaagaa gcatcgcgta gctgtgtcct gatcgaattc
     9181 cggaacctca ataattcgat gttcggttac cgggttttcc gtgccaatga ttatttccct
     9241 gtcaattggc tgcgggtacg caattcgctg cacagtatga aaaagacgga agaccggttc
     9301 agcccgtcac gcatccgtca gataaaaaaa ggactcaaga atggagccaa agtagaggag
     9361 gcacataccg tggaagaaat acacgatttc tcacggatgc tgcacaaggt ttattcctcc
     9421 cgcatacgca gatatttccc tgccaacgac tttttccgtc acatgaacga tatgctaatc
     9481 aaaggacaac aggcaaaaat attcgtagta aaatacaaag agaaaatcat tggcggttcc
     9541 gtctgtatct actcggaaga tgacgcgtac ctttggtttt ccggaggaat gagaaagaca
     9601 tacgcacttc agtatccggg agtactggcc gtttggaagg cattggaaga cgcccgccaa
     9661 cggggattcc gccacatgga atttatggat gtaggacttc cgttccgcaa acacggttat
     9721 cgtgatttcg ttctccgatt cggaggaaag cagagcagta cccgccgctg gttccgtgtc
     9781 aattggaatt ggctgaacaa actcttagtc aaattttatg tctaaatgta atctcaagat
     9841 tgcaaaacga ctcttcatgc tccttcccta ccattttttc tgtttaataa tccaataatt
     9901 aaatgcagaa atatttcttt attaggtaag aaatgtcttt ctttgtgctg ttttatgcca
     9961 tataagcaca tgattaaaac caaataaaaa aagtatagtt atgaagattt cacacattga
    10021 acatctgggc attgctgtaa aaagcatcga agaagccctt ccttactacg aaaatgtatt
    10081 aggtctgaag tgttacaaca ttgaaacagt ggaagatcag aaagtaagaa ctgctttttt
    10141 aaaagtaggc gaaaccaaaa ttgaactgtt ggagccgact tgcccggaga gtactattgc
    10201 caaattcatt gaaaacaaag gtgcaggtgt tcatcacgtt gcctttgctg tagaagatgg
    10261 cgtagccaat gctttggcag aagcagaaag caaagaaatc cgccttatcg acaaagctcc
    10321 ccgcaaaggt gccgaaggtt tgaatattgc tttccttcac ccgaaatcaa ctttgggcgt
    10381 gttgacagaa ctctgcgaac attaatcagt aaaacaaaga tgagtaatca acttgaaaaa
    10441 attaaagagc ttattgaacg ccgtgccgta gcacgtatcg gaggcggtga aaaagcaatt
    10501 gcgaagcaac atgaaaaagg gaaatacaca gcacgcgagc gtctggctat gctgcttgac
    10561 gagggtagct tcgaagaaat ggacatgttc gttgagcaca gatgcacgaa cttcggaatg
    10621 gagaaaaaac attatccggg agacggtgtg gtaaccggct gcggtacaat cgaaggacgt
    10681 ctggtatatg tgttcgcaca ggacttcact gtttctgccg gttcactgtc agaaacgatg
    10741 tcattgaaga tttgtaaaat tatggatcag gccatgaaga tgggtgctcc ttgtatcggt
    10801 atcaacgact cgggtggtgc acgtatccag gaaggtatca acgctttggc aggttatgca
    10861 gaaatcttcc aacgcaacat ccttgcttca ggtgttattc cgcagatttc cggtatcttc
    10921 ggtccttgtg ccggtggtgc tgtttattct ccggctctga ccgacttcac actgatgatg
    10981 gaaggcactt cttatatgtt cctcaccgga ccgaaagtgg tgaagaccgt tacaggtgaa
    11041 gacgttagcc aggaaaacct cggtggcgca agcgttcact ccactaaatc gggtgtgact
    11101 catttcaccg cccaaacaga agaagaaggt ttcgaactga ttcgcaaact gttgagctat
    11161 attcctcaaa acaaccttga agaagctcct tatgtagatt gcacagaccc aatcgaccgt
    11221 ctggaagatt ctttgaacga tattatcccc gacagcccta ctaaaccgta tgacatgtac
    11281 gaagtgatcg gcgctattgt ggacaacggt gaattccttg aaatccagaa agattatgca
    11341 aagaatatca tcatcggttt cgcccgcttc aacggacaat cggtaggtat cgttgctaat
    11401 cagcctaagt atctggctgg tgtgctcgac agcaacgcat ctcgtaaggg tgcacgtttt
    11461 gttcgtttct gcgatgcatt caatattcct atcgtatcgt tggtagacgt accgggattc
    11521 cttccgggaa caggtcagga atacaatggc gttatccttc atggtgctaa actgttgtat
    11581 gcttacggtg aagctactgt gcctaaggtt actatcacat tgcgtaaatc ttacggtggt
    11641 tctcacatcg taatgagctg taagcaactt cgcggtgaca tgaactacgc atggcctact
    11701 gccgaaatcg cagtaatggg tggagcagga gcagtagaag tattgtacgc acgcgaagcc
    11761 aaagatcagg aaaatcccgc tcaattcctt gctgaaaaag aagcagaata cacgaaattg
    11821 ttcgccaatc cttacaatgc agctaaatat ggctacatcg acgatgtgat tgaaccgcgc
    11881 aacacacgtt tccgtgtgat ccgtgctttg cagcagttgc agactaagaa attgagtaat
    11941 ccggctaaga agcatggtaa tattccgttg taatcctact tttcacatta aaacaagaac
    12001 gattatgaac aaaaccaaaa tcggaatatt cctttctttg ctgttgctga ttggtctgac
    12061 ttcttgtgga gagcaaaagt cgaacaataa gctggtgcta aacgaaatcc tgataaacaa
    12121 tcagagtaat tttcaggacg attacggatt gcacagcgca tggattgaaa tattcaataa
    12181 atcattcggt agcgccgacc tggcagcttg cttgctgaaa gtaagcagcc aaccgggcga
    12241 tacagttact tattttatcc cgaaaggtga tatacttacc ttagtgaaac cacgccaaca
    12301 tgcactattc tgggcagatg gcgaacctaa ccgtggtact ttccatacca gcttcaagct
    12361 gaatccggaa acagctaatt gggttggtct gttcgactcc ggcaaaaagt tgctcgacca
    12421 gattgtagtg cccgcaggcg ctctcggtcc caatcaatca tacgctcgtg taagcgacgg
    12481 ggcagctgaa tgggaagtaa aaagtggaag cggtgacaaa tacgtgactc caagcaccaa
    12541 caacaagact cttgacagca attccaagat ggaaaagttt gaagaacacg atgctgatgg
    12601 cgttggaatg tccatttctg ccatgagcgt agtattctgc ggattgattc ttctctttat
    12661 tgcttttaag attgtaggaa aagtagctgt taatttgagc aagcgcaacg ctatgaaatc
    12721 taaaggcatt gacaagcatg aagctaagga actgtcacag gctccgggcg aagtatacgc
    12781 tgctatttct atggcattac acgaaatgca ggatgaggtg cacgacgtag aagaaacggt
    12841 gctgaccatc acccgcgtaa aacgcagcta ctcaccatgg agttcgaaga tttacacttt
    12901 gcgtgaaact cctcccagaa agtaagtcac cttttaaaaa gttaaaacga tgaaagaata
    12961 taaatataaa atcaacggta actcatataa agtaaccatc ggagatattg aagataatat
    13021 cgctcatgta gaagtgaacg gtacacacta taaagtagaa atggagaaac agccgaagcc
    13081 tgttgcgaaa cccgtgacag tacgcccgat gcctaatgct cctgctgctc ctactcaagt
    13141 agtgaaaccg accgctccgt ctaccggaaa atcaggagta aaatctccgc tgccgggtgt
    13201 gatcctcgac atcaaagtga atgtaggcga tactgtaaag aaaggacaga ccattatcat
    13261 attggaagcc atgaagatgg aaaacaatat caatgcggat aaggacggta agattactgc
    13321 catcaacgtc aacaagggag actctgttct tgaaggtaat gacctcgtaa ttattgaata
    13381 atatgggaga ctttataaac tttttaggaa ataacctggc cgacttctgg acatacacag
    13441 gctttgccaa tgctacggta gggcatgtag tcatgattct cgttggcttg gtattcatct
    13501 atttggcaat agccaaagag ttcgaaccaa tgctgctgat tcctatcggt tttggtatat
    13561 tgattggtaa tatacctttt aatatggatg ccgggctgaa agtcggtatt tatgaagaag
    13621 gttctgtatt gaatatattg tatcagggag tgacctccgg ctggtatccg ccactcatct
    13681 ttttgggtat cggtgccatg acggacttct cggcacttat ctctaatcca aaattgatgc
    13741 tgattggtgc agctgcacag ttcggtatct tcggtgcata tatgatcgca ttggaaatgg
    13801 gtttcgaccc aatgcaagcc ggtgctatcg gtatcattgg tggagcagac ggcccgacgg
    13861 ccatcttcct ttcttccaag ctagcaccta acctgatggg agccattgcg gtgtccgcct
    13921 actcctatat ggcgttggtt ccggtgatac agccgcctat catgcgtctg ctcaccacca
    13981 agaacgaacg tgtcatccgc atgaaaccgc cgcgtgccgt ttctcacacg gagaaggtga
    14041 ttttcccgat catcggtttg ttgctgactt gtttcctggt tccttccggt ctgcctttgc
    14101 tgggtatgct gttcttcggt aacctgttga aagaaagtgg tgtaacccgc cgtttggcta
    14161 atactgccag tggtccgttg attgatacaa tcactatcct gttgggtctg acagtaggtg
    14221 cttctacaca agcatccgaa ttcctgacgc ttgactctat caagatcttt gccctcggtg
    14281 cattgtcatt tgttattgca acggcatctg gtgtcatctt cgttaagatc ttcaatatct
    14341 tcctgaagaa gggtaataag atcaatccgt tgatcggtaa tgcaggtgtt tctgctgttc
    14401 ccgactctgc acgtatctcg caagtgattg gtttggaata cgattcgacc aactatttgc
    14461 tgatgcacgc tatgggtccg aacgttgccg gagtgatcgg ttcagctgtt gctgccggta
    14521 ttctgcttgg attcttgatg taagaaacat tatataatag ataagaacac ccgtgttaca
    14581 ttcagttgtg acacgggtgt tctttattac agccatagtg ttatcttctc tccgttctga
    14641 aacgattaaa cgtcataaaa aaggctgcta ccagtgttca aaccggagca gcctctttct
    14701 tttatttatg gaataatccg gagattatta ctgtgccaat ttgttgtcag aaccgagcac
    14761 gttgatgatt ttgtgcttgt acagtttttc catgttgtca cgagccgggc caagatactt
    14821 acgtgggtcg aattcagccg gtttttcagc gaaagtctta cggatagcag cagtcatagc
    14881 cagacgtgag tcagagtcga tgttgatttt gcaaacagca gacttagcag ctttacgcaa
    14941 ttcttcttcc ggaatgccga tagcagcttt cagtgcacca ccatatttgt tgatagtttc
    15001 cacttcttct tccggaactg aagatgatcc gtgaagaacg atagggaatc ccggaagttt
    15061 ttccattaca gcgtccaata cttcgaaagc caatggagga ggaaccatac ggccagtctt
    15121 cgggtcgatg tggcattgtt ccggagtaaa tttgtaagca ccgtgagaag taccgattga
    15181 gatagccaaa gagtcgcaac cagtgcgagt agcgaagtcg attacttctt cagggtcagt
    15241 atatgtgtgg tgatcagcag aaacttcatc ttctacacca gccaatacgc caagttcacc
    15301 ttctacagtt acgtcaaact ggtgagcgta ttcaacaact ttcttagtca atgctacgtt
    15361 ttcttcgtaa ggaagatgag aaccgtcaat catcactgaa gagaaacctg aatcgataca
    15421 agatttgcaa gtttcgaatg tatctccgtg gtcaagatga agaacgattt ccggatgtgc
    15481 gcagcctaat tctttagcat attctaccgc accctgtgcc atgtaacgca acaa
//
