LOCUS       gnlProkkaMBPGOLJE_40   12582 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MBPGOLJE_40.
ACCESSION   gnlProkkaMBPGOLJE_40
VERSION     gnlProkkaMBPGOLJE_40
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:50:25
            Original ID  :: gnl|Prokka|MBPGOLJE_40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12582
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12582
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5446:5746]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5447..5746
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12582
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12582
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..937
                     /locus_tag="ctg40_1"
                     /transl_table=11
                     /translation="MWGSCIAWYLDKIGHNVLSCGLADAPEFIQLKETHKNDYLTFPKS
                     IEVSSNLEYAIERAEVIIISISSQYLRSYFADISKYNLDGKTIVLCMKGVEATTGKRLS
                     EVVGEFVDESKTPVAVWVGPGHPQDYVRGIPNCMVIDSNNHDIKEKLVNEFTSDLIRFY
                     LGTDLIGSEIGAAAKNVIGIAAGMLDGLNYTSLKGALMARGTREIARLIKALGGNEMSA
                     YGLCHLGDYEATLFSKWSHNRMYGESFAKGDRFTKLAEGVMTSKALYKLGQEYGVDLPI
                     VESVYKVLFDGTDIKEALGTLFMRSVKKEF"
     CDS             957..2639
                     /locus_tag="ctg40_2"
                     /transl_table=11
                     /translation="MGNTKAKNNSNKPKQTGKTVTSVKKQNTVEYVIVNILCLFVFIAF
                     AYIAIMSFVQTSVFDSANYGSEVILYQTDNIALNILFTSLFTVFIFKMKKHCDFFAKVN
                     LKYMHIGLAAFVMIVGLVWIFSVTSVPAADSYNIYETASQAAKGNYSSFHNNSGFYNSD
                     FYSGYSYYNFYPFQLGFVFISEIFYRIFGTDSTMPIQVFNVMCTAAAYIGIVNITRLLF
                     KKRSVEFITILLLAGCFQPVLFCTFVYGNIIGMCFAIWASYFLIKYFQTNKYLLLIPCA
                     VLLVISTLAKYNNLIYLVAFVVMLIIHTIKAKKWQSIAFALAICIAVVGTSNLVIISYE
                     NRSGVKLSSGVSQAMYLDMGINDSYMAPGWYNGIALNDYKNAGLDAKAANAQAWTNIKS
                     RMNYFGKNTNYMIDFFSKKIISQWNEPTYESIWVSKVKSHTNELNWIGNGMYDGSIGQF
                     FELYFNFYMQILFIAFAAGIYFLFINRKTNIETVLLPLVILGAFGYHLLFEGKSQYVLT
                     YIILMIPTASFAFECILNGKYTKIKEFVGKLKEIPDGKESEKA"
     CDS             complement(2661..3527)
                     /locus_tag="ctg40_3"
                     /transl_table=11
                     /translation="MVRIITDSAADFEHSESEKFGISTIPLAVYIDGKEYKDDFLHSKE
                     RFYRLAKLSKTLPKTSQPSPYVYECALKKARDNGESVVVITVSSALSGSYQSAVLARDL
                     LGYEGCYVIDSKSASAGQKLLVNEALRLRDNGFTAKEIAEHLLRFRSKIMVYACIDDMK
                     YLYGGGRHTNAAALLGSTGRIKPVISITGSGSVAFEAKTIGMRHGMNHMLMSLKKLGID
                     QNYPLYIMHTNAKNQALYLSKLIISKGIPFVEGSIVSVGSVVGSHIGEGSTGIAFVKKE
                     QRKSGHD"
     CDS             complement(3633..4547)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_4"
                     /sec_met_domain="NTP_transf_5 (E-value: 4.2e-26, bitscore:
                     81.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKKQDIYSXXXXKEYPRSDFRSVSDVDILFDRKQADSVKKVFSK
                     LGYTFLNEDDNQYHFEKKPMMNIEMHATLVHENEESYPLLVNQLDRSTKRDGYSYSYEM
                     SHEDFYIYMLVHNSNHFRIGGMGARMVLDSYVFLKNHQSELDYDYLNVMLEKIGIAKYE
                     KRVREIAFNWFAKPQAELKFDDIEEYILLSGTLGRVDVGTMINSHKTITENNKSKFSYL
                     VSSIFPPKSEMQYKYPYVKKTPFLLPISWCHMWGKRLFVDRNINFKSGIKNRMSYTDED
                     VNLYKSLLDEMGFDGIGINNFGN"
     CDS             complement(4972..5460)
                     /locus_tag="ctg40_5"
                     /transl_table=11
                     /translation="MSLNKEVGLDDVMQIIAEKLETGGSVTFNPKGTSMLPMLRDGDDT
                     VVLSKPKGRLHLFDLPLYRRKDGSYVLHRVVNFGSDGSYTMCGDNQFAVEKGITDDDVI
                     GVVTAFYRKGKPYTVDSMKYRAYLEFMFYSKPLRKVIASTVSRSKNAFSKLKTKKGKK"
     CDS             complement(5447..5746)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_6"
                     /sec_met_domain="PF05402 (E-value: 1.5e-17, bitscore: 53.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.7e-14,
                     bitscore: 42.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEKFTRKTGDFMKIKEDFVLRKVADSYVVVPVNKLTLDFNGIIN
                     LNETGAFLFEKLQNDCEKADLLKAMLDEYEVSEEKASADIDTFIQKLREADVLE"
     CDS             complement(5859..7487)
                     /gene_functions="other (smcogs) SMCOG1299:chaperonin GroEL
                     (Score: 814.4; E-value: 5.8e-247)"
                     /gene_kind="other"
                     /locus_tag="ctg40_7"
                     /transl_table=11
                     /translation="MAKQIAYGEDARKALMKGIDQLADTVKITLGPKGRNVVLDKKFGA
                     PLITNDGVTIAKEIELEDPFENMGAQLVKEVSIKTNDIAGDGTTTATLLAQALIREGMK
                     NVTAGANPMVLKKGIADAVNVAVEAVKKNSKQVSGTDDIARVATVSSQDEFIGKLIAEA
                     MEKVTTDGVITVEESKTAETYSEVVEGMMFDRGYIAPYMVTDTDKMVAELDNPLILITD
                     KKISTTQEILPLLEQIVQMGKKLLIIAEDVEGEALTTLVLNKLRGTFTCVAVKAPGFGD
                     RRKEMLQDIATLTGGTVITSDLGLELKDTTVDQLGTARQVKIEKENTIIVDGSGDKEAI
                     KGRVAQIRQQIETTTSDFDREKLQERLAKLAGGVAVIKVGAATEVEMKEKKLRIEDALA
                     ATKAAVEEGIVAGGGIACMNAIPAVAEFVDTLEGDAKTGAKIVLKALEEPLRQIVANAG
                     LEGSVICDNVKKANKVGYGFNALTEEYTDMVSAGIVDPTKVTRSALQNASSVAAMVLTT
                     ESLVTDIKEPAAPAAPAAPDMGGMY"
     CDS             complement(7516..7800)
                     /locus_tag="ctg40_8"
                     /transl_table=11
                     /translation="MTIKPLLDRVVLKVEEAEEKTKSGIILSSAAQEKPQFASVVAVGP
                     GGVVDGKEVKMYVSVGDKVIASKYAGTQVKIDGEEYTIVNQSDILATLE"
     CDS             complement(8064..9770)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 81.2;
                     E-value: 1.5e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg40_9"
                     /sec_met_domain="Pkinase (E-value: 3.7e-14, bitscore: 42.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLWYNSFQTKFEIDTYLELSNNMSLCMGCMQEIGDNKICPSCGF
                     DTTEKQQAPFLPYGTILQNRYIVGAGIDTNGESTRYISHDKQTGDIVIICEFLPIGLFS
                     REEGTTEVRINYENRLVYNKLKDDFLNYYRILSELRELSALMNVHNIFEENNTVYVVEE
                     NEDLIPFEEYVERSNGHLEWDIARPLFMPVISALEALHKRGVGHYAIAPKNMYITASGK
                     IKISGFASENERKRGTPLKSQLFSGAAAPEQYDDNFPLDDITDIYGFCATLFYALTGHM
                     PKSAVERRKDSRLLMSTTTVKRLPPHVVSALANGLQVERENRITDFDELRSQLSVAHTA
                     KAIQDEISRTASMNLTKSERTRKTSNGMSHASIIIIAAAITVLVLGIAGVFWLMQNPLA
                     GMFSNNTDASVSSTQSTEWTGATVPNYIGMTYEEAVKSVDSNSSITIYRTFNDEYSDDY
                     AEGKIMSQTPAAGSKITQEDSVVVSVCVSKGSQMRTLPKVEGEKLDTVASDIAAQGLLA
                     TAEYEYSDKVAEGRVIRYKEHVEGDTLEYGSTVVLVVSKGKKQTSSQSSNR"
     CDS             complement(9815..9985)
                     /locus_tag="ctg40_10"
                     /transl_table=11
                     /translation="MYLVYVKSNVNIIWGYSSAGRVSDWQSEGHGFEPRYLHHIFYTTI
                     FAKNLLYKALQ"
     CDS             complement(10011..10640)
                     /locus_tag="ctg40_11"
                     /transl_table=11
                     /translation="MRCVIIAGSPDTNSDFLSEVIKPDDYVICADRGCNFAKQAGITPN
                     LVVGDFDSEPDVLFPNCETVRLIPEKDDTDTMHSVDLALEKRFDEIAILGALGGRFDHS
                     FANVAVLSYIHEHGSKGVLLSEKEKIEFLPVGHYEYKNFKGKTFSLFPFGCPSVCVSYS
                     GTKYPLEKYCVSSSVTLGVSNVFTSDMTTIDIYDGNAILIINLIDC"
     CDS             complement(10643..11530)
                     /locus_tag="ctg40_12"
                     /transl_table=11
                     /translation="MDTKSGILMKSIGGFYYVRADGEDYECKARGSFRKSGNSPVAGDR
                     VNISVPNDGFCAIEEILPRKNKLRRPALANLDILLLVCSTVEPLPNFTIIDKMTAAAVN
                     NNMEPVIVVTKNDLENGDKIADIYRHAGFEVFLCSEDDSSQTEELKSYLSGKVSAFIGN
                     SGVGKSTLLNKLFPSLSLETGQTSKKLGRGRHTTRVVELFELDGCFVADTPGFSTVDLQ
                     RYEMIDKSRLQYCFPEFEKYLGDCMFTSCSHTCEKGCRILEALSDGEIEETRHRSYVQM
                     YNEVKDIKSWQIKE"
     CDS             complement(11541..12581)
                     /locus_tag="ctg40_13"
                     /transl_table=11
                     /translation="MCAIFFALAMFRGCSTSQAKDVEVPDYVGKSFVSIKENNPNDFKF
                     EVKSEYDESKEMGVILDQEPKGGSMKVKSGSTITVTVNGTDTEVSVPYVTNYSEKEASQ
                     ALKEKNLIPEIVYVENTKTPKGYTIECFPKAGVKTTIGSTVYVYIASGERTKQVTLPSV
                     DGLMLSEAKQTLVDLGLTVETVQDDESKEPKDTVLGMSPLQYGKVDAGSVVTLTVSSGL
                     GDENTVNIFVDLPSDVEDSVDMTVIVDGAVDSRNSKTLVPKYNKTYTLELKGSGTSTVV
                     IQLDGQAYREYSVDFASAAVTTTASHDYVRATTAPPETEPPTQYYTDPYVAPDTTVQPV
                     TDDPEL"
ORIGIN
        1 acgctggggc agctgcattg cctggtatct cgacaaaatc ggtcacaatg ttttaagctg
       61 cggacttgcc gacgcacccg aatttataca gcttaaagaa acacacaaaa acgactatct
      121 cacctttcca aagtcaattg aggtttcttc gaatcttgaa tatgcgattg aaagagccga
      181 ggttattata atttcgattt catcgcagta tctgcgttcg tattttgcag atatttcaaa
      241 gtacaatctt gacggcaaga caattgtcct ctgcatgaag ggtgttgagg caactacagg
      301 caaaaggctc agtgaggttg tcggtgaatt tgttgacgaa agcaagacac ccgttgcagt
      361 ttgggtaggt ccgggacatc cccaggatta tgtaagaggt attccgaact gtatggttat
      421 tgacagcaat aatcacgata ttaaggaaaa gcttgtaaat gaattcacaa gcgaccttat
      481 cagattttac cttggaacgg atcttatcgg cagtgaaatc ggtgctgccg caaagaatgt
      541 tatcggcatc gccgcaggta tgcttgacgg acttaactac acctcactaa aaggtgcgtt
      601 aatggcaaga ggcacacgag agattgcaag actcattaag gcactcggag gcaatgagat
      661 gagtgcttac ggtctttgtc atctcggcga ctatgaggct accttgtttt caaaatggag
      721 tcacaacaga atgtacggtg aaagctttgc aaagggagac agatttacaa agcttgccga
      781 gggtgttatg acatcaaaag cgttatacaa gctcggtcag gaatatggtg ttgaccttcc
      841 gattgttgag tctgtataca aggttttatt cgacggaaca gatatcaaag aggcactcgg
      901 aactctgttt atgcgttctg tcaagaaaga attttaatcg ggcaggtaca tataatatgg
      961 gtaatactaa agctaagaac aattcaaata aacctaaaca gactggaaaa acggttactt
     1021 ctgtcaaaaa gcagaataca gtcgagtatg ttattgtaaa cattctttgt ctgttcgtat
     1081 tcatagcatt tgcatacata gcaattatga gctttgtgca gacaagcgtg tttgattcgg
     1141 caaattacgg cagtgaagta attttgtatc agacggataa cattgcgctg aacatcctgt
     1201 tcacttccct gtttaccgtt tttatattca aaatgaaaaa gcattgtgac ttttttgcaa
     1261 aggtcaatct gaaatatatg catataggtc ttgcggcatt cgttatgatt gtgggacttg
     1321 tctggatatt ctcggtaacc tctgttcctg cggctgacag ctacaacatc tatgaaacag
     1381 cgtcgcaggc ggctaagggc aactattcgt cattccacaa taacagcggt ttttacaaca
     1441 gcgattttta cagcggatat tcttactaca acttctatcc gttccagctt ggctttgttt
     1501 tcatcagcga aattttttac agaattttcg gtacggacag tacaatgccg attcaggtat
     1561 tcaatgtaat gtgtacagcc gccgcttata taggtattgt aaatatcaca agacttcttt
     1621 tcaaaaagcg ttcggttgaa tttattacaa ttcttctgct tgccggctgt tttcagcccg
     1681 tacttttctg cacattcgtt tacggcaaca tcatcggaat gtgctttgca atctgggcat
     1741 catacttcct catcaagtat tttcagacaa acaagtacct gctcctcatt ccgtgtgccg
     1801 tacttctcgt tatttcaaca cttgcaaaat acaacaacct gatttatctt gttgcgtttg
     1861 ttgttatgct gattattcac acaattaagg ctaagaagtg gcagagcatt gcgtttgcac
     1921 ttgcaatttg cattgctgtt gtcggaacaa gcaaccttgt tatcataagt tatgagaacc
     1981 gttcgggagt gaagctttca agcggtgttt cacaggctat gtaccttgat atgggcatta
     2041 acgattcata tatggctccc ggttggtaca acggaattgc cctcaacgat tataaaaacg
     2101 caggtcttga cgcaaaagcc gcaaatgcac aggcttggac caatataaaa tcaagaatga
     2161 attactttgg taaaaacaca aactatatga ttgacttctt ctcgaagaaa attatcagcc
     2221 aatggaatga accgacatac gaaagcatat gggttagcaa ggtcaagtct catacaaacg
     2281 aacttaattg gatcggcaac ggaatgtatg acggcagtat cggacagttc tttgaactgt
     2341 acttcaactt ctatatgcag attcttttca ttgcgtttgc ggcaggaatt tacttcttgt
     2401 tcattaacag aaagacaaat attgaaaccg tacttctccc tcttgttatt ctgggagcgt
     2461 tcggatatca cctcttattt gaaggcaagt cgcagtatgt gctgacttac ataattctta
     2521 tgattcctac tgcgtctttt gcatttgagt gtattcttaa cggcaaatat acaaaaatca
     2581 aagaatttgt cggaaaactg aaagaaattc ccgacggtaa agaaagcgaa aaagcctgat
     2641 aaaatgattg aagcggacag ttaatcatgt ccgctttttc tttgctcttt tttgacaaat
     2701 gcaatacccg tactgccctc tcctatatga ctgccaacaa cagaacccac gctgacaata
     2761 ctgccctcaa caaaaggaat tccttttgat attatgagct ttgataaata caatgcctga
     2821 ttttttgcgt ttgtgtgcat tatatacagc ggataatttt ggtctatgcc aagctttttc
     2881 agcgacatca gcatatgatt cataccgtgg cgcattccga ttgttttcgc ctcaaaggct
     2941 acactgcccg aacccgtaat gctgattacg ggttttattc ttcctgttga gccgagtaat
     3001 gcggcggcat ttgtatgtct gccaccccca tagaggtact tcatatcgtc aatacaggca
     3061 tataccataa ttttacttct gaacctcaga agatgttcgg caatttcttt tgctgtaaac
     3121 ccgttgtcac gcaggcgaag tgcctcgttt acaagaagct tctgacctgc cgaagcagat
     3181 ttgctgtcta tcacataaca cccctcatat ccgagcaaat ctcttgcaag aactgcactc
     3241 tgatatgaac cgctcaatgc cgaagaaaca gttatcacca caaccgattc gccgttatct
     3301 ctcgcctttt tcaaagcaca ttcgtagaca tacggcgagg gttgagaggt tttcggcaaa
     3361 gttttcgaca gctttgcaag cctgtaaaag cgttcctttg aatgtaaaaa atcatcctta
     3421 tattcttttc cgtcaatata cacagctaac ggaattgtag aaattccgaa tttttcactt
     3481 tctgaatgtt caaaatcggc ggctgaatcg gtaataattc tgaccattta ggtatcacct
     3541 caaaaataat atcttgaaat attattttca aatttacctt tattatgcaa aaatcccgac
     3601 agcaaaaact gtcgggaggt tgatttgcat attcaatttc cgaaattatt tattccaata
     3661 ccgtcaaagc ccatttcatc caaaagggac ttgtacaaat ttacatcttc atccgtgtat
     3721 gacatacggt ttttgatgcc cgatttaaaa ttgatatttc tgtctacaaa aagccttttt
     3781 ccccacatat gacaccatga aatcggtaaa aggaacggtg ttttttttac atatggatac
     3841 ttatactgca tttcggattt tggtggaaat attgaggaca caagatatga gaatttagat
     3901 ttgttattct cggtaattgt cttgtgggaa tttatcatcg tgccgacatc taccctgccg
     3961 agtgtaccgc tgagcagaat atattcttcg atatcatcaa atttaagttc agcctgtggc
     4021 tttgcaaacc agttgaacgc aatctcacga acacgctttt catactttgc aataccgatt
     4081 ttttcaagca tcacattaag atagtcataa tcaagctcag attgatgatt tttcaagaaa
     4141 acatagctgt caagcaccat tcttgctccc attccgccga ttctgaaatg attcgagtta
     4201 tgaacaagca tatagatata aaagtcctca tggctcattt catatgaata gctgtagccg
     4261 tcacgctttg ttgaacggtc aagctgatta acaagcaacg gataagattc ctcgttttca
     4321 tggacaagag ttgcatgcat ttcaatgttc atcatcggct ttttttcaaa atgatactgg
     4381 ttgtcatctt cattcagaaa agtgtatccg agtttggaaa atactttttt gaccgaatca
     4441 gcctgttttc tgtcaaaaag gatatctaca tcagacacgg aacgaaagtc ggaacgggga
     4501 tattcctttn nnnnnnnnna tgaataaatg tcttgttttt tcaccatatt ctgttctcat
     4561 ccaagaattg gatgtaataa aagttaaaac cccatttttt ttcaaaacat ctattccttt
     4621 ttcataaaat agccctttaa gggaatattc ttgattttgt tttcatcaaa agccttgaga
     4681 attttctcgg tttcatatga gagatttccg tcaatcagca tttcaaccga caaattctgc
     4741 ttgaattttt catatacttc gggcgaaaca tactttttgt caagcgacaa aaccgcnnnn
     4801 nnnnnnnnnn ggcaacaagc gattcaacac tgcaatagtt tgcaagcatt tttatcgact
     4861 gccattttat cccctcataa ggaatcggag gtgctgttcc gtttacagac gatgaaacaa
     4921 gctcaagcag atacttaaat tcaatttttt cgttatcgtt aagatgtttc ctcatttttt
     4981 cccttttttc gttttaagct ttgagaatgc atttttactt cttgacacag ttgatgcaat
     5041 aacctttctt aacggttttg aatagaacat aaattcaagg tatgctctgt acttcattga
     5101 gtcaaccgtg tagggcttgc cctttctgta aaaggctgtt accactccga ttacatcatc
     5161 atcggtaata cctttttcaa cggcaaactg attgtcaccg cacatagtat aactgccgtc
     5221 acttccgaaa ttgacgacac ggtgcaatac atacgagccg tcttttcgtc tgtataaagg
     5281 caagtcaaaa agatgaagtc tgcccttcgg ttttgataaa acaaccgtat cgtcaccgtc
     5341 tcggagcatt gggagcatac ttgttccctt cggattgaaa gtaaccgatc ctccggtctc
     5401 aagcttttcg gctataatct gcattacatc atcaagacct acttctttat tcaaggacat
     5461 cagcctctct tagcttttga ataaatgtat caatatcggc actcgccttt tcttcgctca
     5521 cttcatactc atcaagcatt gctttgagca aatcagcctt ttcgcaatcg ttttggagct
     5581 tttcaaaaag gaatgcaccc gtttcattga ggttgataat tccgttaaaa tcaagcgtca
     5641 gcttatttac gggaactaca acatacgaat ctgcaacctt tcgcagaaca aaatcttctt
     5701 ttattttcat aaaatcacct gttttccgcg tgaatttttc atccatatat tataatatac
     5761 ctttcgacaa aaagcaagaa aaaggatttg agcataaaat taccgcagac cttttgagtc
     5821 tgcggtaaaa attatctata atattacagc ttacgggatt agtacattcc gcccatatca
     5881 ggtgctgcgg gagctgccgg agctgcaggc tctttgatgt ctgtaacaag tgattctgtt
     5941 gtaagaacca ttgctgcaac agagcttgcg ttctggagag ctgaacgagt aacctttgtt
     6001 gggtcaacga tacctgccga aaccatatct gtgtattcct ctgtaagagc gttgaagcca
     6061 tagccaacct tgttagcctt cttaacatta tcgcagatta cgctgccctc aagacctgcg
     6121 ttagcaacaa tctgacggag cggttcttca agtgctttaa gaacaatctt agcacctgtc
     6181 ttagcgtcac cctcgagagt gtcaacaaac tctgcaacag ccggaatagc gttcatgcaa
     6241 gcgataccgc cgcctgctac gataccctct tcaacagcag cctttgtagc ggcaagagca
     6301 tcctcaatac ggagcttctt ttctttcatt tcaacttctg ttgcagcacc aaccttgata
     6361 actgctacgc cgcctgcgag ctttgcaaga cgctcctgaa gtttttcacg gtcaaagtca
     6421 gatgttgttg tttcaatctg ctgtctgatc tgagcaactc tgcccttgat agcttccttg
     6481 tcacctgagc cgtcaacgat gattgtgttt tccttttcaa tcttaacctg acgggcagta
     6541 ccgagctgat caactgttgt atccttgagt tcaagaccga ggtcggatgt gataaccgta
     6601 ccgcctgtga gtgttgcgat atcctgaagc atttcttttc ttctgtcacc aaagcccgga
     6661 gcctttacgg caacacaagt gaatgtacct ctgagtttgt taagtacgag agttgtaaga
     6721 gcctcgcctt caacatcttc agcgataata aggagcttct tacccatctg aacaatctgc
     6781 tcaagaagtg ggagaatttc ctgtgtagta gaaatcttct tatctgtgat aaggataagc
     6841 ggattgtcaa gctctgcaac catcttatct gtatctgtta ccatataagg agcgatgtaa
     6901 cctctgtcaa acatcatacc ttcaacaacc tcgctgtatg tttcggctgt ctttgactcc
     6961 tcaactgtga taacaccgtc tgttgtaacc ttttccatag cctcggcaat aagcttgccg
     7021 atgaattcat cctgtgatga aactgttgca actcttgcga tatcgtctgt accggatacc
     7081 tgcttgctgt tcttctttac agcctcaact gcaacattta cagcgtctgc aatacccttt
     7141 ttaagtacca ttgggttagc gcctgcagtt acattcttca taccctctct gatgagagcc
     7201 tgagcaagaa gtgtggcagt tgttgtaccg tcgcctgcga tatcgttagt cttgatagaa
     7261 acttccttta caagctgagc acccatattt tcaaaaggat cttcaagttc aatttcctta
     7321 gcaattgtta caccgtcatt tgtgatgagc ggagcaccga acttcttatc aagaacaaca
     7381 tttctgccct taggtccgag tgtgatttta acggtatcag cgagctggtc gatacctttc
     7441 attaaagctt ttcttgcatc ttcgccgtat gcgatttgtt tagccattgt aaattacctc
     7501 cgtatattta gttaattatt caagagttgc gagtatatcc gactggttta cgattgtgta
     7561 ttcttcgccg tcaatcttta cctgtgtgcc tgcatattta cttgcgataa ccttatcgcc
     7621 tacgctgaca tacatcttta cttccttgcc gtcaacaaca ccgccggggc caacagcaac
     7681 aactgatgcg aactgtggct tttcctgagc agcagatgaa agaatgatac cgctctttgt
     7741 tttctcttca gcctcttcaa cttttaaaac gactctgtcg agtaatggtt tgattgtcat
     7801 aaatacagcc tcctgtaaaa attttaaatt gcttttaatt aattagcact cttgttccct
     7861 gagtgctaat tatattttat accattttca agaaaagtca agagaaattt gactattttt
     7921 gacctttatt ttgtgacagt tttctgaaat tttttccaat ctcaatttta tcgagtattt
     7981 taagataatc agtaactata actgttttat ttcaataaaa aagacggact gcaaaaagtc
     8041 cgtcttaaac attgttatta attttatctg tttgatgatt gagaacttgt ctgtttcttg
     8101 cccttgctga caacaagaac taccgttgaa ccgtattcga gagtatcacc ctcaacatgt
     8161 tctttgtagc ggattaccct tccctcagca accttgtcac tgtactcata ttctgctgtt
     8221 gcaagaagtc cctgagcggc aatgtcggat gcaacggtat caagtttttc accctcaacc
     8281 ttcggcagag tcctcatctg tgatcccttg cttacgcaaa cactcactac tacggaatct
     8341 tcctgagtga tttttgaacc tgcggcagga gtctgtgaca taatcttacc ttctgcataa
     8401 tcatcgctgt actcatcgtt aaaggttctg tagattgtga tactgctgtt gctgtcaaca
     8461 ctcttaacag cctcttcata tgtcattccg atatagttag gaacagtagc acctgtccac
     8521 tctgtgcttt gagttgagct tacactcgca tcagtattat ttgagaacat tccggcaagc
     8581 ggattctgca taagccagaa cacaccggca ataccgagaa caagaaccgt gatagcagcc
     8641 gcaataataa taattgaagc gtgtgacata ccgtttgaag tcttgcgtgt acgctctgac
     8701 tttgtgaggt tcatgcttgc tgttcttgaa atttcgtcct gaattgcctt tgctgtatga
     8761 gcaacggaaa gctgtgaacg aagctcgtca aaatctgtaa tacggttttc acgctcaacc
     8821 tgcaaaccgt tagcaagagc cgaaacaaca tgcggaggaa gtctctttac tgttgttgta
     8881 ctcataagaa gtcggctgtc cttacggcgt tctaccgcac tctttggcat atgacctgtg
     8941 agggcataga aaagggttgc acaaaatccg tagatatccg taatatcgtc aagaggaaaa
     9001 ttatcgtcat actgttcggg agccgcagcg cctgagaaaa gctgagattt gagaggcgtg
     9061 cctcttttac gctcattttc cgacgcaaag cctgaaattt taattttacc cgatgctgtg
     9121 atatacatat tcttaggtgc gatagcatag tgaccgacac ctctcttgtg aagagcctca
     9181 agagcagaaa ttacaggcat aaaaagcgga cgggcaatat cccattcaag atgaccgtta
     9241 ctgcgttcaa catactcctc aaaaggaata agatcctcgt tttcctcaac aacataaact
     9301 gtgttatttt cttcaaaaat gttgtgaaca ttcataagag cggaaagctc acggagttct
     9361 gaaagaatcc tgtaatagtt aagaaaatcg tccttgagtt tattatatac aaggcggttt
     9421 tcataattta ttctgacctc ggtagttcct tcttcacgag aaaaaagtcc gataggaaga
     9481 aattcgcaga tgattacaat gtcacctgtc tgcttgtcgt ggcttatata gcgtgtgctt
     9541 tcgccgttgg tatcaattcc cgcacctacg atatagcggt tctgaagaat tgttccgtac
     9601 ggtaaaaaag gagcttgctg tttttcagtt gtatcaaatc cgcaggacgg acaaatcttg
     9661 ttgtcaccta tttcctgcat gcatcccata cacaatgaca tattattact caactccaaa
     9721 taagtatcaa tttcaaattt tgtctgaaaa gaattatacc ataaaaacat atttcttttc
     9781 aagacttaaa ggtgttaata tagttacaat tttgttattg caaagcctta taaagcaaat
     9841 tctttgcaaa tattgttgta taaaaaatgt ggtggagata acggggctcg aacccgtgac
     9901 cttctgactg ccagtcagac actctcccag ctgagctata cccccatata atgttgacat
     9961 tgcttttgac atatacaaga tacatttgca aacaatgtca agctgtaatt ttaacagtct
    10021 atcaaattaa ttataagtat tgcatttccg tcatatatgt caattgttgt catatcggaa
    10081 gtgaatacat ttgaaacacc cagagtaacg ctgctcgaaa cacagtattt ttcaagagga
    10141 tactttgttc ccgaatagct tacgcagaca ctcggacatc cgaaagggaa aagcgaaaat
    10201 gttttgcctt taaagttttt atattcataa tgacctacgg gaagaaattc tattttctct
    10261 ttttcagaaa ggagaacgcc cttacttccg tgttcgtgaa tataagagag aaccgccaca
    10321 tttgcaaagc tgtggtcaaa gcgaccgccc aatgcaccga gaattgctat ttcgtcaaac
    10381 cttttttcaa gtgcaaggtc aacagagtgc attgtgtcgg tatcatcctt ttcgggaata
    10441 agtcggaccg tttcgcagtt tggaaacagt acatcaggct cggaatcaaa atctcctaca
    10501 acaaggttcg gagtaatgcc tgcctgtttt gcaaaattgc agcctctgtc ggcacatatc
    10561 acatagtcat caggttttat aacctcggac aaaaaatccg aatttgtgtc aggcgagcct
    10621 gcaataatca cacaacgcat aattactcct ttatctgcca tgatttaatg tccttgacct
    10681 cgttatacat ctgaacataa ctgcggtgac gggtttcttc aatttcaccg tcagagagcg
    10741 cctcaagaat cctgcagcct ttttcacagg tatgcgaaca tgaagtaaac atacagtccc
    10801 ctaaatattt ttcaaattca ggaaagcaat attgcagccg gcttttgtca atcatttcgt
    10861 aacgctgaag atcaacggtt gaaaatccgg gtgtgtctgc cacaaaacaa ccgtcaagtt
    10921 caaacagttc aacaactctt gttgtatgtc ttcctctgcc gagttttttg cttgtctgcc
    10981 ctgtttcaag agaaagcgat ggaaaaagct tattgagcaa tgtggacttg ccgacgccgc
    11041 tgttaccgat aaaggctgaa accttgccgg acagatagct tttgagttct tcggtttgtg
    11101 aagaatcatc ttccgaacag agaaaaacct caaaacctgc gtgtctgtag atatcggcaa
    11161 tcttatctcc gttttccaga tcattttttg taacgacaat tacgggttcc atattattgt
    11221 ttaccgccgc cgcagtcatt ttgtcaataa tcgtaaaatt cggcaacggt tcaacagttg
    11281 aacacacgag aagaagaata tcaagatttg caagagcagg tctgcggagc ttgtttttgc
    11341 gtggaagaat ttcttctatc gcacaaaaac cgtcattcgg aacagatata tttaccctgt
    11401 cccccgctac gggagagttt ccgcttttgc gaaagctccc ccttgcctta cattcgtaat
    11461 cctcgccatc ggcacggaca tagtaaaatc cgccgattga tttcattaaa attccgcttt
    11521 tagtatccat acttcaccga ttaaagttca ggatcatccg taaccggctg aacggtcgtg
    11581 tcaggcgcta catacggatc tgtgtaatac tgcgtcggcg gttcggtttc gggaggagcg
    11641 gttgtcgcac ggacataatc atgtgacgcc gtagtggtta ccgctgccga tgcaaagtca
    11701 accgaatact ctctgtacgc ctgaccgtca agctgaatta ctacagttga agtgcctgag
    11761 cccttgagct caagagtata ggtcttgtta tatttcggaa caagtgtctt tgaattacgg
    11821 gaatcaaccg caccgtcaac aattacagtc atatcgactg aatcttcaac atccgacgga
    11881 aggtcaacga agatattaac cgtgttttcg tcaccgagtc ccgagcttac agtcagggtt
    11941 acaacagagc ctgcgtcaac cttgccgtac tggagaggcg acataccgag gactgtatcc
    12001 tttggttctt tgctttcatc atcctgaact gtttcaacgg taagtccgag atcaacaaga
    12061 gtctgctttg cttcggaaag cataagtccg tcaaccgacg ggagtgtaac ctgtttggtt
    12121 ctctcaccgc ttgcaatata tacatatacc gttgaaccga ttgtagtttt tacacctgct
    12181 ttcgggaagc actcaattgt gtagcccttt ggtgttttag tgttttctac atagacaatt
    12241 tcaggaataa gattcttttc cttgagagcc tgagaagcct ctttttcgct gtaattggtt
    12301 acataaggaa cagaaacctc tgtgtccgtt ccgtttacgg ttaccgtgat tgttgagcct
    12361 gacttaacct tcattgaacc gcccttaggc tcttgatcaa gaattacgcc catttccttt
    12421 gactcatcat attcactctt aacctcaaac ttgaaatcat tcgggttatt ttcttttatt
    12481 gaaacaaagg atttgccgac ataatcggga acttcaacat ccttagcctg tgaggttgag
    12541 cagcctctga acattgcaag tgcaaagaaa attgcacaca ct
//
