LOCUS       gnlProkkaMBPGOLJE_49   11590 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MBPGOLJE_49.
ACCESSION   gnlProkkaMBPGOLJE_49
VERSION     gnlProkkaMBPGOLJE_49
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:50:25
            Original ID  :: gnl|Prokka|MBPGOLJE_49
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11590
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1470
                     /locus_tag="ctg49_1"
                     /transl_table=11
                     /translation="MLNLGIPVVKTCATDKKGLDELKKAIYNVCSGKTKCFRVERNFEG
                     VDILSEKNYKQNIEKLSQIGNKISSDCVKYEKSELNACTRKLDKILTSKTTGIPIMLAM
                     LGILFWITVVGANYPSEWLSNLFGFIKEKLYILFDFLHAPDVVTGLLIDGVYTTLSWVV
                     SVMLPPMAIFFPLFSLVEDSGYLPRIAFNLDRYFSKCGAHGKQSLAMAMGLGCNACGVT
                     GCRIIESPKERLIAILTNNFMPCNGRFPTIIALLLMFFAGTAFTLSSSLEVAALLIGII
                     VFCVFITLVISKVLSVTILKGEQSGFVLELPPYRKPQILKTIVRSLLDRTLFVLGRAVA
                     VAAPAGAIIWILANVHISDVSLLKYCTDFLDPFGRFIGVDGVIIMAFILGFPANETVIP
                     IIIMSYMASGTLVDYSSYDQLFQLLSMNGWTITTAVCTIILCILHYPCSTTCLTIKKET
                     GSLKWTLVSMALPTAMGIVLCMITAGVMRLF"
     protocluster    1..11590
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2336:3710]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2337..3710
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11590
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11590
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(1462..2271)
                     /locus_tag="ctg49_2"
                     /transl_table=11
                     /translation="MNEKIIMLGTGSAMVTDCYNTCFLLKSENDCLLVDAGGGNGILSA
                     IKKSGIAWNSIKTMFITHSHTDHILGAVWVIRQISALMNSGKYDGNFNIYCHDECVDSI
                     TAICNHTLAPKFLKNINTKIFINEVKDGEKQNVGSIRLTFFDIFSDKTKQFGFKAVFPS
                     GKVLACLGDEPFNEKCRNFVQNCDYLMCEAFCLYSQKDIFKPYEKFHSTALDAGKLAES
                     LFAKNLILYHTEDETLQTRKRTYTSEARTVFNGNIFVPDDFEVIDLK"
     CDS             complement(2337..3710)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_3"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.1e-31,
                     bitscore: 98.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-15, bitscore: 46.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.5e-15, bitscore: 46.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.9e-21, bitscore:
                     63.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKLNGYNIVLDVYSGSVHAVDDLAYDVIAMYKNATKEQIID
                     EMLSKYADNPEITKEEISDCIDDVKELEEQGKLFTDDKYENLAFDFKKRNTVIKALCLH
                     IAHTCNLNCEYCFASQGKYHGERALMSFEVGKRAIDFLIENSGSRVNLEVDFFGGEPLM
                     NFDVVKQIVAYARSIEKEHNKNFRFTLTTNGMLVDDDVIEFANKECHNVVLSLDGRKEV
                     HDHLRKTVNGKGSYDIIVPKFQEFVKKRGNKGYYVRGTYTHNNTDFTNDIFHMADLGFT
                     ELSMEPVVCAPDDPYALTYDDLPILFEQYEILAKEMLKREKEGRPLTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDEKYKLGDIFNGVSNTKIQDEFKLCNA
                     YARPDCKDCWARLYCSGGCAANAYHATGSITGIYEYGCELFRKRMECAIMMKVAEAEE"
     CDS             complement(4006..5409)
                     /NRPS_PKS="Domain: Aminotran_5 (54-217). E-value: 7e-13.
                     Score: 40.0. Matches aSDomain:
                     nrpspksdomains_ctg49_4_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_4"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5e-12, bitscore:
                     35.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3e-10, bitscore:
                     29.3, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 2.1e-13, bitscore:
                     39.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYDKLKNYSKSGIYPFHMPGHKRTDITEEGIIPYNIDITEIHDF
                     DNLHSPNGVIDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMARNCHK
                     SVYNAAELFNLNADYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSPTYEGV
                     VSDIKSISEICHRHGAKLLVDEAHGAHFPFSDNFPDEALNCGADAAVLSLHKTLPSLTQ
                     TALLITNDSELSEILAENLAVFETSSPSYILMSSIEKCLDFCENSKDKFNEYCCNLKTV
                     REKLKNLKYLKIYDKSDTDFDYDIGKIVISTANANISGTKLAEILRNNYQIETEMAYSD
                     YVIAMTSVCDTEKAFDMLSDALISIDSKLSKGADTERVPLKNLYTGKNFNACELYKFNK
                     ETIPFQNSEFRTSAEYIWAYPPGIPLIVPGEIISKELINYIEYLSACKVEIMSTKGGMT
                     DNISVVKKD"
     aSDomain        complement(4759..5247)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg49_4_Aminotran_5.1"
                     /evalue="7.00E-13"
                     /label="ctg49_4_Aminotran_5.1"
                     /locus_tag="ctg49_4"
                     /protein_end="217"
                     /protein_start="54"
                     /score="40.0"
                     /tool="antismash"
                     /translation="IDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMA
                     RNCHKSVYNAAELFNLNADYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSP
                     TYEGVVSDIKSISEICHRHGAKLLVDEAHGAHFPFSDNFPDEALNCGADAAVLSLHKTL
                     "
     CDS             complement(5433..7019)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 109.2; E-value:
                     4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_5"
                     /transl_table=11
                     /translation="MSSFKEEISKRRTFAIISHPDAGKTTLTEKLLLYGGAINLAGSVK
                     GKRTAKHAVSDWMEIEKQRGISVTSSVLQFKYNGYCINILDTPGHEDFSEDTYRTLMAA
                     DSAVMVIDGSKGVEKQTIKLFKVCVMRNIPIITFINKMDRDAKNSFDLLEDIENVLGIH
                     TYPVNWPIGSGKEFKGVYDRNSKKILAFTANNGQKEVEKKELTLDDPALEDTIGYYHKQ
                     DLFDEIELLDGAGDEFDLEAVRNGQLTPVFFGSALTNFGVEPFLEQFLQLTTPPLPRET
                     VDEKVEPMSDFFSAFVFKIQANMNKAHRDRVAFMRICSGKFEKNMEVFHVQGNKKMRLS
                     QPQQIMAQEREIVDEAYAGDIIGVFDPGIFSIGDTICSPGHKVQFRGIPTFAPEHFALV
                     RQKDTMKRKQFIKGTSQIAQEGAIQIFQELDAGMEEVIVGVVGVLQFDVLKYRLQNEYN
                     CDIIMETLPYEFIRWIVNDDLDPKTLDLASDTKKIQDLKGNHLLLFTSYWSINWALEHN
                     KGLELAEFGTN"
     CDS             7185..8369
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_6"
                     /sec_met_domain="PF04055 (E-value: 4.1e-21, bitscore: 65.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFPIFSYTFQIEAETCVSASKSFMRFFMSNSIGLYIHIPFCKHK
                     CPYCDFFSGNADENAFDNYVIELKDKIKYWSEKAKRDVATVYFGGGTPSVLGADRLCDI
                     LDFIKFNFNIQNNAEITVEVNPDSAKTIDFKKMYACGFNRISMGMQTAVEDELRLLGRI
                     HSIDDAKTSVERAKSAGFNNISLDLMMGIPNQTIESLEKSISFCADCKVTHISSYILKI
                     EENTPFYKVQNKLKLADDDMQAEMYLRAVEMLDSLGYKQYEISNFAKHGYESRHNTNYW
                     RCGEYIGIGPSAHSFFEGKRFFYSRSMDDFNNNKLSFEGTGGDEEEFIMLSLRLKSGLN
                     YSEFEEKFGYTLPSYIIKKAKEYEKYGYTNVTDKSISFTPKGFLVSNSIISELI"
     CDS             complement(8429..9328)
                     /locus_tag="ctg49_7"
                     /transl_table=11
                     /translation="MKFCKYCGAQLEDNAVCNCEKSRAAQAQAQQANAQAQPQYQQPVQ
                     PQQPQYQNPVQQQYTQPQNPQTQQSPYAVNNTAPIGENAFVKALKNIPVVFTSFFKDSK
                     TVIKTAKAEKDIILGALFSAIFFIALILGNMFLMLSMSALDFPKTLLVSLVTAVLIGGF
                     YSVILFAYVKKYKTEENTAKAFIDSFITFSIESIPASIGWILAGLCALISVYMFLFFFV
                     IVMLYLVISLVNQVKANVPEAKNSALFTLILTLIVAVAFMIVFFIGAKLTMWSFNTGTF
                     TTSVLTSLIGGGSYPSLY"
     CDS             complement(9580..10287)
                     /locus_tag="ctg49_8"
                     /transl_table=11
                     /translation="MDNSSNMAVNTTPTANQINPEHHYGLDKNKACLNNSCPSNTADSG
                     CYIPAIDEIMRHNQGAPSVAHPNMTEKVQKSNDNPSLEQAEIAYEEGGSTSEEQPENIN
                     KYSGSLQNIPFIKNLKKIDTSIPVLPATPATTASSGATVATPIRQNIGMSMSDYQYPFP
                     VTAENLRYHNGFMRTQIGRRITVDFLMGANTIVQKTGYLLGVAQDYILINEIDTNDITT
                     CDYYNIKFIRYYY"
     CDS             complement(10302..10745)
                     /locus_tag="ctg49_9"
                     /transl_table=11
                     /translation="MALSTRELLARLLKCEAGGEGENGMRAVASVIVNRTRVPNGEFAR
                     VSKGGDFRAIMEQPNQFTCLKTTVGGQYNPQNVYNIRPDEIHYNIADWALAGNTDSSVG
                     NSIFYFNPFSDTCPTFFPSNNGVIYNRVGDHCFYSPTEAYSKT"
     CDS             complement(10939..11256)
                     /locus_tag="ctg49_10"
                     /transl_table=11
                     /translation="MDEEYDDWLVNDDGKNNINDLIKETVALETTGKTGFFYLDKKRTQ
                     NIFKKSGYQLPSQLKNSGSNIIIRTIDDSVNKKSIILLKANNLSDGSVIGKIALQKQVK
                     R"
     CDS             complement(11337..11537)
                     /locus_tag="ctg49_11"
                     /transl_table=11
                     /translation="MIARKYLDNYSEIILNSLNLYSDNTTLRVSNSMTSDETLLKMEKL
                     MKDNPTEQELIKRLGKNFPQE"
ORIGIN
        1 tcgctaaacc tcggaatacc tgttgtgaaa acctgtgcaa cagacaaaaa aggtctggat
       61 gaattaaaaa aagcgatcta taatgtatgc agcggaaaga caaaatgttt tagggtagaa
      121 agaaattttg aaggcgttga tatactatcc gaaaaaaact acaaacagaa tattgaaaag
      181 ctttcgcaga ttggcaacaa aatttcaagt gactgcgtaa aatatgaaaa atcagagtta
      241 aatgcttgta caagaaagct tgataaaata cttacaagca aaaccacggg aataccgatt
      301 atgcttgcaa tgcttggtat attgttctgg ataacagttg tcggtgcaaa ttatccgagc
      361 gaatggttaa gcaatttgtt tggctttata aaagagaaac tgtatattct ttttgatttt
      421 ttacacgctc ccgatgttgt aacgggactt ttgattgacg gagtttatac aactctgtca
      481 tgggtggtat ctgtaatgct gccgcctatg gctatattct ttccgttgtt ttcgcttgtt
      541 gaggattcgg gatatctgcc gagaattgca tttaatcttg ataggtattt ttcaaagtgc
      601 ggtgctcacg gaaagcaaag tcttgctatg gcaatgggtc ttggctgtaa tgcctgcgga
      661 gttacaggtt gcagaatcat cgagtcgcca aaggaacgac tgattgcaat tcttacaaat
      721 aattttatgc cgtgtaacgg acggtttccc acaataattg cattactgct catgttcttt
      781 gcaggtacgg catttacgct gagcagttcg cttgaggtag cggcattgtt gattggaata
      841 atagttttct gtgtttttat aacacttgtt atatctaagg tactttcagt cacaatattg
      901 aaaggcgaac agtccggatt tgtgcttgaa cttccgccgt acagaaagcc gcagatttta
      961 aaaactattg tccgttcgct gttggacaga actttatttg ttttaggaag ggctgttgcg
     1021 gttgccgctc cggcaggtgc gataatctgg attcttgcaa atgtgcatat aagcgatgtt
     1081 tcacttttaa aatattgtac tgatttttta gatccgttcg gcagatttat cggggttgac
     1141 ggcgttataa taatggcatt tatacttgga tttcctgcga atgaaaccgt tattccgatt
     1201 ataattatgt catatatggc aagcggtact cttgttgatt attcaagcta cgatcagctg
     1261 tttcaacttc tcagtatgaa cggctggacg attacaacgg ctgtatgcac gattattctt
     1321 tgcattcttc attatccgtg ttcaacaacc tgtctgacaa taaaaaaaga aacaggcagc
     1381 cttaaatgga cgcttgtttc tatggctttg cctactgcaa tgggaattgt gctttgtatg
     1441 attacagcag gtgttatgag attattttaa gtcaataact tcaaaatcat cgggaacaaa
     1501 tatatttccg ttaaaaactg ttctcgcctc tgaagtatat gttcttttgc gtgtttgaag
     1561 tgtttcgtcc tcggtgtgat acaggataag attttttgca aaaagactct ctgcaagttt
     1621 tcctgcatca agtgctgtgc tgtggaattt ttcgtaaggc ttaaaaatat ctttttgact
     1681 gtaaagacaa aaagcttcac acataagata atcacagttt tgaacaaaat ttctgcattt
     1741 ttcattgaac ggttcatcac cgagacaggc gagaactttt cctgacggaa aaacagcctt
     1801 gaatccgaat tgctttgttt tgtctgaaaa tatatcaaag aaagtgagtc ggatactgcc
     1861 gacattttgt ttttcaccgt cttttacttc attgatgaaa atttttgtat tgatattttt
     1921 gagaaatttc ggtgcaagtg tgtggttgca aattgccgtg attgaatcaa cacattcatc
     1981 gtggcagtaa atattaaaat taccgtcata tttgcctgaa ttcataagag cgcttatttg
     2041 ccttattacc cacacggcac ctaaaatatg gtcggtgtga gaatgagtaa taaacattgt
     2101 ctttatgctg ttccaagcta ttccggattt cttaattgcg gataaaattc cgtttccgcc
     2161 gcctgcatca acaagaagac agtcgttttc ggatttcaga agaaaacagg tattataaca
     2221 gtcggtaacc atcgcacttc ctgtgccgag cataataatt ttttcgttca tacagcacct
     2281 cgaaaataca ggcagataca agaaaaatgt atctgcctgt aaattttatt gtaattttat
     2341 tcttctgctt ctgcaacctt catcataatg gcacattcca ttctttttct gaaaagctca
     2401 cagccgtatt cgtaaatacc tgtgattgag cctgttgcat gataagcgtt tgcggcacaa
     2461 ccgccgctgc aataaagtct tgcccagcag tctttgcagt caggacgggc gtatgcgtta
     2521 caaagcttaa attcgtcctg aattttcgtg tttgaaacac cgttaaagat atcgccgagc
     2581 ttgtactttt catcgcctac aaactgatga cagggataga ggtcgcccca aggtgttaca
     2641 gccatatatt ctgtacccga accgcaaccc gagattctct tataaatgca cggaccgcct
     2701 gtaaggtcaa tcatataatg atagaaggtg agcggtctgc cctctttttc acgcttgagc
     2761 atttcctttg caagaatttc gtactgttca aaaaggatag gcaaatcgtc atatgtaagt
     2821 gcatatgggt catcgggagc acatacaacc ggctccattg aaagctctgt aaatcccaaa
     2881 tccgccatat ggaaaatatc gtttgtgaag tctgtgttat tatgtgtata agtgcctctt
     2941 acatagtaac ccttgttacc tctttttttg acaaattcct ggaatttcgg aacgataata
     3001 tcataactgc ctttgccgtt tacagttttg cgaagatggt catgcacttc ttttctgccg
     3061 tcaaggctga gaactacatt atgacattct ttgtttgcaa attcaattac atcgtcatca
     3121 acaagcatac cgtttgttgt aagtgtaaaa cggaagtttt tgttgtgttc cttttcaatg
     3181 cttcttgcat aggcaacaat ctgctttaca acatcaaagt tcataagagg ttctccgccg
     3241 aagaagtcaa cctcaaggtt tactctgctg cctgaatttt caatgagaaa gtcaattgct
     3301 ctcttgccca cttcaaagct catcagcgct ctctcgccgt ggtatttgcc ctggcttgca
     3361 aagcagtatt cgcagttaag gttacaggtg tgagcaatgt gcagacaaag tgctttgatt
     3421 actgtgtttc tctttttaaa gtcaaatgca aggttttcgt acttgtcgtc tgtaaagagc
     3481 tttccctgtt cctcaagctc ttttacatca tcaatgcagt cggagatttc ttcttttgta
     3541 atctcaggat tgtctgcata ttttgaaagc atttcgtcga ttatctgttc ttttgttgcg
     3601 tttttgtaca ttgcaataac atcataagca aggtcatcga ctgcgtgtac actgccgctg
     3661 taaacatcaa gaactatgtt gtatccgtta agtttatact gatgaatcat aatatctccg
     3721 ttagacaaaa ggaaagccgt taaccctttg ggaaaacggc gataatcctt aataatcaaa
     3781 ttaaaataga attatttctc gctcatgcac ttttcgcact gctggttagc aacgccgcaa
     3841 gatgtcttac acgctgactg acatgaagtc tggcactcgc cgcaaccgcc tgtcttaacg
     3901 ctcttcttga ggtcacgagt ttcgatagtt ttaattctct tcataataaa tcaaactcct
     3961 tgttagattt tgttagttta atattatcac acagccattg atttgtcaat cttttttaac
     4021 tacgcttatg ttgtccgtca taccgccttt tgttgacata atctcaacct tgcaggctga
     4081 aagatattca atgtaattta taagttcctt gcttataatt tcaccgggta cgatgagggg
     4141 aattccgggt ggatatgccc agatatactc ggcagaagtt ctgaattccg aattttgaaa
     4201 cggaatagtt tctttgttga atttgtacaa ctcgcaggcg ttgaaatttt tgcctgtgta
     4261 gagatttttt aacggaacac gctcggtgtc ggctcctttt gaaagtttgc tgtcaattga
     4321 aatcagagcg tctgaaagca tatcaaaagc tttttcagtg tcacaaacag atgtcatggc
     4381 aattacatag tccgaatatg ccatttcggt ttcaatctga taattatttc gcagtatttc
     4441 ggcaagcttt gttcccgaaa tatttgcgtt cgctgttgaa attacaattt tgccgatatc
     4501 ataatcaaaa tcagtatcgc ttttatcata aattttcaga tattttagat ttttaagttt
     4561 ttctctgacc gttttaagat tgcaacaata ttcattgaat ttatctttgc tgttttcgca
     4621 gaaatcaaga catttttcga ttgaactcat taaaatatat gacggactgc ttgtttcaaa
     4681 tacagccaaa ttttcggcaa gaatttcaga aagctcgctg tcatttgtta tgagcaatgc
     4741 agtttgagtt aatgacggca aagttttgtg cagactcaat actgcggcgt ctgcaccgca
     4801 gttaagtgct tcatcgggaa aattgtccga aaacggaaaa tgcgctccgt gagcttcgtc
     4861 aacaagtaat tttgctccgt gcctgtgaca gatttcggaa attgacttta tatccgaaac
     4921 aactccttca tatgtaggcg aagttatgat tacaagtctg atttcatcat tgtgttttgt
     4981 aagtttatct tctatatcgc aaggtgaaac cgatgtaaga atattgtatc tgctgtctgt
     5041 atcgggaaaa atgtaatcag cattgagatt aaacagttcc gctgcattat atacagattt
     5101 gtggcagtta cgagccatta agatcttgtc gccttgattt gtcattgagc gaattgctga
     5161 aagtattccg cctgttgaac cgttaatcag aatgaaagca ttttttgcat tgtaaagttt
     5221 tgcagccttt ttctgaattt catcaataac tccgtttggt gaatggagat tgtcaaaatc
     5281 atgaatttcg gttatgtcga tattatacgg tattataccc tcttctgtaa tgtccgttct
     5341 tttgtgtccg ggcatatgaa aaggatatat gccgcttttt gaataatttt taagcttgtc
     5401 gtacagcata tatcctccga tattttaaat atttagtttg taccgaactc agcgagttca
     5461 agtcccttgt tgtgttcaag cgcccagttt atgctccagt agcttgtaaa gagcaaaaga
     5521 tgattgcctt taagatcctg aattttctta gtatcggacg caagatcgag agttttcgga
     5581 tcaaggtcat cgtttacaat ccaacggata aattcatatg ggagtgtttc cataatgata
     5641 tcacagttgt actcgttttg aagtctgtat ttaagaacat caaactgaag tacgcctaca
     5701 acgccaacga taacttcctc catacctgcg tcaagctcct ggaaaatctg aattgcacct
     5761 tcctgtgcaa tctgacttgt acccttgatg aactgtttgc gcttcattgt gtctttctga
     5821 cggacaagtg caaagtgttc gggagcaaat gtaggaattc ccctgaactg taccttgtgt
     5881 cccggtgaac agattgtgtc accgattgag aaaatgcccg gatcaaacac accgatgatg
     5941 tcgcccgcat atgcctcgtc aacaatttct ctttcctgag ccataatctg ctgtggctgt
     6001 gaaagacgca tttttttgtt gccctgaaca tggaacactt ccatattctt ttcaaacttg
     6061 ccgctgcaga tgcgcataaa tgcaactctg tcacggtgag ccttattcat gtttgcctga
     6121 attttgaaaa caaatgcaga gaaaaagtct gacataggct caaccttttc atcaactgtt
     6181 tctcttggca gaggtggagt tgtgagctgt aagaactgtt caaggaatgg ttcaacacca
     6241 aagtttgtaa gagccgaacc gaagaataca ggagtaagct gaccgttgcg gactgcttca
     6301 aggtcaaatt catcgcctgc accgtcaaga agttctattt catcaaacaa atcctgctta
     6361 tgatagtagc ctattgtatc ttcaagggca ggatcgtcaa gcgtaagttc tttcttttca
     6421 acttctttct gaccgttatt agcggtgaaa gcaaggattt tcttagaatt tctgtcatac
     6481 acacccttga attccttacc tgaaccgatt ggccagttta cgggataggt gtgaattccg
     6541 agaacatttt caatgtcttc aagaaggtca aaagaatttt ttgcatctct gtccatcttg
     6601 ttgatgaatg taatgatagg aatattacgc attacacaga ccttgaaaag tttgatagtc
     6661 tgtttctcaa caccctttga accgtcaatt accattacgg cagagtctgc cgccataagt
     6721 gtacggtagg tatcttccga gaaatcctca tgtcccggtg tgtcaagaat atttatgcaa
     6781 taaccgttat atttaaactg caaaaccgat gatgtaacag aaataccacg ctgtttttca
     6841 atttccatcc agtcggacac agcatgcttt gcggttcttt tgccttttac cgaacctgca
     6901 aggttaattg ctccgccgta gagcaagagc ttttccgtaa gtgttgtttt acccgcatca
     6961 ggatgcgaaa taatcgcaaa ggttctgcgc ttgctgattt cttctttaaa tgaactcata
     7021 tctttcttcc cttcggaggt taagtatatc cacaattcta tattttacta tttttggatg
     7081 gtatatgtca ataaagaatg aagaaaatgt gagaaaaata attgctacaa aaacttgaca
     7141 aatttgtaaa tatattgtaa tatattggta cagaaggact taatgtgatt tttcctattt
     7201 tttcatatac cttccaaatc gaggcagaaa cttgtgtttc tgcctcaaaa tcatttatga
     7261 ggttttttat gagtaattct atcggtcttt acattcacat accgttttgt aagcacaaat
     7321 gtccgtattg cgattttttc agcggcaatg cagacgaaaa cgctttcgat aattatgtga
     7381 ttgaattaaa agataaaata aaatactggt ctgaaaaagc caaaagagat gttgctaccg
     7441 tatatttcgg cggcggtacg ccgagtgttt tgggtgcaga cagactttgt gatattcttg
     7501 attttatcaa gttcaatttt aatattcaaa ataatgccga gattacagtt gaagtcaatc
     7561 ccgactccgc caaaactatt gattttaaaa aaatgtatgc ctgcggattt aatcgcattt
     7621 caatgggtat gcagactgct gttgaagatg aattaaggct gcttgggaga attcacagca
     7681 tagatgacgc aaagacttct gttgaaaggg ctaaaagtgc gggatttaat aatatttcac
     7741 ttgatttgat gatgggaatt cctaatcaga caattgaaag ccttgaaaaa tcaatcagtt
     7801 tctgtgccga ttgcaaagtt actcatattt catcatacat tttgaaaatc gaggagaata
     7861 ctccgtttta taaggtgcaa aataaactta agcttgccga tgatgatatg caggccgaaa
     7921 tgtatctgag agctgttgaa atgcttgatt ctctcggata caagcaatat gaaatttcta
     7981 attttgcaaa acatggttat gaaagccgac ataataccaa ttactggaga tgcggtgaat
     8041 atatcggcat aggtccgtct gcacactcat tttttgaggg caaaaggttc ttttattcga
     8101 gaagcatgga cgattttaat aacaataagc tgtcttttga aggtacgggc ggagatgagg
     8161 aagaatttat tatgctctct ctcaggctga aaagcggtct taattattct gaatttgagg
     8221 aaaaattcgg atacactctc ccctcttaca ttatcaaaaa agctaaagag tatgaaaaat
     8281 acggctatac aaatgttaca gacaagtcaa tcagctttac accgaaaggt tttcttgttt
     8341 caaattcaat aatcagtgaa ctgatataaa aaacgctccg agaataaatt cggagcgtta
     8401 attttatgtt atgaatttgt atgtcagatt aatacaatga agggtatgaa ccgccgccga
     8461 taagcgatgt aagaacactt gttgtaaatg tacctgtgtt aaatgaccac atagtaagtt
     8521 ttgcgccgat gaagaataca atcataaatg caacggcaac gatgagcgtg agaattaaag
     8581 tgaataatgc agagttcttt gcttcgggaa cattagcttt tacctgattt acaagtgaaa
     8641 taacaaggta aagcataacg attacgaaga agaacaggaa catatatacg ctgattaatg
     8701 cgcaaagacc tgccaaaatc caaccgattg atgccggaat agattcaatt gaaaatgtga
     8761 tgaatgaatc aataaatgct ttggctgtgt tttcttcggt tttgtatttc tttacatatg
     8821 caaagagaat aacagaatag aagccgccga taaggacagc agtaacaaga cttacaagaa
     8881 gtgttttcgg aaaatcaagt gcgctcatag aaagcataag aaacatattg ccaagaatga
     8941 gtgcaataaa gaaaattgcc gagaaaagag cgccgagaat gatgtccttt tcagcctttg
     9001 ctgttttgat aacagttttg gaatccttaa agaatgaagt gaacacaaca ggaatgttct
     9061 ttaaagcctt aacaaaagca ttttccccaa tgggtgctgt gttatttacg gcataaggcg
     9121 actgctgtgt ctgagggttt tgcggctgtg tatactgttg ctgaacaggg ttctgatact
     9181 gtggctgttg tggttgaaca ggctgctgat actgaggctg tgcctgtgca tttgcctgct
     9241 gagcctgtgc ttgagcggct cttgactttt cgcagttgca aacagcattg tcttcaagct
     9301 gtgctccgca atatttacag aatttcatgg tgattcctcc aagataaaat aatatgtaac
     9361 aggtcttata gctacctgtt gtttgtttat tgagaagtga taacatcaac gctcacatta
     9421 tatcacaaat tacagcaata attcaatatt tcttacaatt ttttaatttt ttacactaca
     9481 gaaaattata tgttaaaata atgaaatgat gtacagttcg caaataatta caataaaaca
     9541 gcggcaaaaa ctataaactt tagtttttgc cgctgtggtt tagtaataat accttataaa
     9601 ttttatattg tagtaatcac aggttgtgat gtcgttggtg tcaatctcat ttataaggat
     9661 ataatcctga gcaacaccta aaagatagcc tgttttctga acaattgtgt ttgctcccat
     9721 gagaaaatca acggtgattc gtcttccgat ttgtgttcgc ataaaaccgt tgtgatatct
     9781 cagattttcg gctgttacag gaaacggata ttgataatca ctcatcgaca ttccaatatt
     9841 ctgccttatc ggcgttgcaa cggtggctcc ggagctcgcc gttgtagcag gggttgcagg
     9901 caaaacaggt atagatgtat ctattttttt taagttctta atgaacggta tattttgaag
     9961 acttccgctg tatttattta tattttcagg ttgttcttct gatgtacttc cgccctcttc
    10021 atatgctatt tctgcctgtt caagcgaggg attgtcattt gatttttgaa ctttttctgt
    10081 catattgggg tgtgcaacag acggtgcgcc ctgattgtgt cgcataattt cgtcaatcgc
    10141 aggaatataa catccgctat ccgctgtgtt tgacggacat gaattgttga ggcaggcttt
    10201 gtttttgtca agtccgtaat gatgttcggg attaatctga tttgccgtag gagttgtatt
    10261 aactgccata tttgaagaat tatccattaa gctatgctcc tttatgtttt ggaataagcc
    10321 tcggtaggcg aataaaagca atgatcccct accctgttgt aaattactcc gttgtttgac
    10381 ggaaaaaatg ttggacaggt atctgaaaat ggattaaaat agaaaattga atttccgaca
    10441 gatgaatcgg tattgcccgc caatgcccaa tcggcaatgt tatagtgaat ttcgtcaggg
    10501 cgtatattat aaacattctg aggattatat tgtcctccga cagttgtttt aagacaggta
    10561 aattgatttg gttgttccat tatggcacgg aaatctccgc ccttgctgac tcttgcaaat
    10621 tccccgtttg gaacacgggt tcggtttaca attaccgacg caacggcacg cattccgttt
    10681 tcaccttccc cacctgcctc acattttaaa agccttgcaa gcaattctct tgtactcaat
    10741 gccacctttt ttcaccaacc gttattttat tcaatgatat tttatgcata aattaacttg
    10801 ttgttacaaa gaaaaagctt gcgataaatg tgttattcac gcagacagaa aattctgttt
    10861 tatagaagca actcagacgg tgttcgataa tcttttgaga tgccaactac aacatttatt
    10921 cagattagct gttgctgtct accgctttac ttgcttttgc agggctattt tgccaatcac
    10981 cgaaccatca gataaattgt ttgctttgag taatattatt gattttttat tgacactatc
    11041 atcaatagtg cgtataatga tattggaacc cgaattttta agttggctgg gtaattggta
    11101 ccctgacttc ttaaaaatat tctgggttct ttttttgtct aaataaaaaa atcctgtttt
    11161 ccctgttgtt tctaaagcaa cagtttcttt gattaaatca ttgatgttgt ttttgccgtc
    11221 atcgttcaca agccaatcat cgtattcttc gtccattaaa aatttcagcg tatcgtgtat
    11281 tacactggct ttttcatctg taaaatcata atcttcatca agcgagaatt tttcttttac
    11341 tcctgcggaa agttcttgcc caatctcttg attaactcct gctctgttgg attgtccttc
    11401 attaactttt ccatttttaa cagagtttcg tccgatgtca ttgaattgct tactcttaat
    11461 gttgtattat ccgagtataa gttcaaactg tttagtataa tctctgagta attgtctaaa
    11521 tactttcttg ctatcataat tgttttcctc taatttaatt ataaaatttg cgattttgtt
    11581 gccatcggtt
//
