LOCUS       gnlProkkaEPBLLOKO_23   13675 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPBLLOKO_23.
ACCESSION   gnlProkkaEPBLLOKO_23
VERSION     gnlProkkaEPBLLOKO_23
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 15:16:37
            Original ID  :: gnl|Prokka|EPBLLOKO_23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13675
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13675
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7080:8669]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7081..8669
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13675
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13675
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(3..2057)
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIE"
     CDS             complement(2095..2619)
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             complement(2767..4479)
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDYSIIGKNKNVVKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             complement(4561..6969)
                     /locus_tag="ctg23_4"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             complement(7081..8448)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_5"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.3e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8.6e-17, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 7.5e-15, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.9e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             complement(8529..8669)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_6"
                     /sec_met_domain="TIGR03973 (E-value: 2.6e-28, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 3.3e-28, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             complement(8743..9093)
                     /locus_tag="ctg23_7"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSIMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             complement(9143..10648)
                     /locus_tag="ctg23_8"
                     /transl_table=11
                     /translation="MSNNIRIRKNKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDSDNVDKTEGSGKTDPTENADPTETPETSSE
                     KPAADENADTDNKEDKESKSDQDNKTDTDNEENKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGADDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSVNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVAVFIKKRKK"
     CDS             10993..12276
                     /gene_functions="other (smcogs) SMCOG1273:hypothetical
                     protein (Score: 354.6; E-value: 1.3e-107)"
                     /gene_kind="other"
                     /locus_tag="ctg23_9"
                     /transl_table=11
                     /translation="MDSSIAFQAVAILILIALSSFFSSAETAMTTVNKIRIQSLAEQGN
                     KRAVILEKIISNSPKMLSTVLIGNNIVNMSVSSLMTTLTIKILGNAYVGITTGILTLLI
                     LIFGEITPKNLATIHAEKLSLAYSRIIYGLMILLTPVVFIVNKITEGVLVILHVNPDEK
                     ANAMTEHELRTLVNVGEKDGVIENEEKQMIYNVFDFGDSTAKDVMIPRIDMTFIDINFS
                     YDELMAVFSEDMHTRFPVYEDNTDNVIGIINMKDLLVYPKDKPFSIRNILREPYFTYEY
                     KATADLMIEMRKASVNLAIVLDEYGATAGLVTLEDLLEEIVGEIRDEYDEDEVEDIKEI
                     QPEREYVVQGSAKLDDINEALHINLESEDYDSIGGYIIEQLDCLPKEGQSVTLESGIRL
                     VVDRLDKNRIELVHIWLPEKKTETEEQP"
     CDS             complement(12280..12882)
                     /locus_tag="ctg23_10"
                     /transl_table=11
                     /translation="MMNDVYEKFLKSSEEFIFAENKPEKSDIIFVPGNGYPQMAEKAAE
                     LFKKGMADWILPSGKYSVVNGKFSGVLEKSNVYDKEYGTEWEFLRDVLIKNGVPDQKIL
                     KEDQATFTYENAIYSRQVTDHAELEIERAILCCKSYHARRCLMYYQLLYPKTEFYVVPV
                     NADGITRENWRKNEEGIDAVTGELSRIVKQFSLMLER"
     CDS             complement(13161..13673)
                     /locus_tag="ctg23_11"
                     /transl_table=11
                     /translation="MNQYNGAEVLIYDKSGIKYQMAENILGALGEVGFREIGVKERPGL
                     VVLRRTRMPALLIETGFINSEEDNKLFDNKFSDIAQGIADAILGSLDEETVQEPLYYRV
                     QTGAFRKKENADRMLYQLLEKGYPSFMLHENGLYKVQTGAYQQIGNAVNMEQRLRDDGY
                     STVIVTK"
ORIGIN
        1 gcctcaatca gtcgtgtcct gtctgtctca gacatattca gcacattgac acaatctgta
       61 cgatggattg tgattccacg tcctcttgta acaaagccta caatctcatc acccgggatt
      121 ggattacagc acttggaaaa acggactgcc acatcatgga ttccttttac cacaattcca
      181 ctcttgctct tggcaatgtg aagcttctcc tgtgtctcag aagcagcctc aagaacctgc
      241 tcatctgtca gattcttctt attttcctta tcataagcct ctaccagctt attgaaaacc
      301 tgaccttctt tcaatccgcc atgaccaatt gcagcaagta ctgaatccca gtccctgaaa
      361 ccatatttac gcaaaacagc ctccagatac tgggtttttg tataatttgc gatcttaaat
      421 ccctttgcac gcgcatactg cgcaagcatc tccttgccct taaggatatt atcttctttt
      481 aattccttct tgaaccactg gttaatcttg ttctttgcct gagtactctt aaccagtttc
      541 agccagtcgc ggcttggtcc ctgagagttc tgggaagtaa tgatctcaat acggtcaccg
      601 tttttgatct catattcaat cggaaccagc ttaccgttaa ctctggcacc taccatctta
      661 tttccgactg cactgtgaac actgtacgca aaatccaccg gtgtagaacc gcttggaagt
      721 gttttaacat ctccctgtgg agtgaaacag taaacactgt ccgcaaaaag atccaggtca
      781 ttcttcagaa gactcatgaa ttctttgtta tcagacatgt ctctctgcca ttccagaatc
      841 tgacgcagcc agttcagttt ctcttcctca ctcttaccta caggagcttt tccgtcagac
      901 gactccttat atttccagtg tgcagcgata ccatattctg cagttctgtg catttcataa
      961 gtacggatct ggatttcaaa gggctgtccg ttgggtccga tcaatgtggt atgcaatgac
     1021 tgatacatat tgggtttcgg catggcaata taatctttaa accgtcccgg aattggctta
     1081 tacatctcat ggatcacacc aagggcagca taacaatcct tcactgtatc tacaagaata
     1141 cggacagcaa ataaatcata aatctgatca atagtcttat cctgatttac catcttcttg
     1201 tagatgctga aaaagtgttt tacacgtccg tccacctgcg ccttaatatt ggcatcatcc
     1261 atatgtttct taacttcttt tacaatcgca cctacaaact gttctctctc gcttttacgc
     1321 agggcaacct tatgcaccag gtcataatat acatccggct taaggtattt cagcgacagg
     1381 tcatccagct ctacctttat cttggaaata cccagacgca tggcaatagg agcataaata
     1441 tccatggtct ctctggcctt ttcctgctgc ttttcaggac gcatatactg taaggtacgc
     1501 atattatgaa gacggtctgc aagcttgatc agaataactc tgatatcctt agccatggca
     1561 agaaacatct ttctgaggtt ctctgcctga acttctactt tatccgcaga ataagataac
     1621 tgtcccagct tggtaacacc atccacaaga agtgcaacct ctgaaccaaa ttccttctca
     1681 acttcctcat aggtcatcca ggtatcttca actgcatcat gaagaagacc tgcaactatc
     1741 gtttctttgt caagttccag atctgccaga atgatggcaa cacacaaagg atgaatgata
     1801 tatggctctc cagactttct cttctgtcct tcatgagctt cacttgcaac cttatatgcc
     1861 ttctctatca tggaaatatc tgttgatgga tgatacttca gaacactgtt tatcagttct
     1921 ttataaagca cctccggact tgtaaaatca tgcatggtct ttactgccgc atctgctctc
     1981 tttacagatt ccagcttctc tttttcaacc tgcatttcat ctttttttgc ttctgtactt
     2041 tttgttatct ctgtcatatg ctcccacctg cctgtcctgc acaatcagct gtgcttattt
     2101 accatcataa caaattacgg acgctacatc atacccattc agtctttcgc gtccctttaa
     2161 acctgcaagt tccatgagaa atacaacctt gacaacctca ccgccaagct gttccaccag
     2221 cttgatcgct gcttcgatcg taccgcctgt tgcgatcaga tcatcaacga taaccacttt
     2281 ctgacctggt tttatggaat ctttatgcat ttcaatctct gcactgccat attccagatc
     2341 atagcttaca gatactgttt cgcggggaag tttgcctttt ttacgaatcg gtacaaatgg
     2401 tttatgaaga ttatatgcga tcggtacacc aaagataaag cctctggact ctgttcctgc
     2461 aatcacgtcc acatctatat ccttaagaca gtcctgcatg gagtcgattg ccaactgcag
     2521 gccatccgcg tcctgcagaa cacttgtaat atctctgaaa ataatccccg gttcaggaaa
     2581 atccggtata cttaatacat aatcttcaat tttcttcatt ttatttctcc tccagtgtgt
     2641 gttatattgc tgttcgctca taaatatttt atagtatatc acctttttat ttcagaatca
     2701 agttactgtt aagccctgac atttgtattt ccaggcttac cggcggttac aaaccaagcg
     2761 gtaatattaa cagtaattct gaataataat ctgaagactc tctcgtcccc tgaatctgtt
     2821 gatctccgga taataagtaa cagaaatact gtctttttcc ctgataaagt tcacaaaatc
     2881 ctctgcttct ccgaaataaa tgccttccac tgaaatcccc tgcggatcga gaagttttag
     2941 ttttactaca tttttatttt tcccgataat actgtaatca agcactctga gatttttctg
     3001 tgcaaagacc ggttttgtat tcccttttcc aaagggttcc agaagcgaaa tctgttctac
     3061 cagttctttt gtaatataag acacaggcat cggcacatca atcacgatct taggacgcaa
     3121 ttcttcgtcc gtcaacgtac agttgacatt gaggcgtctc cggaattctt ctatattttt
     3181 ttcttctata gaaagacctg ctgccatcgg atgacctcca aactgtatca tcaggtctgc
     3241 acattttacc agttcttcat acatagagta actttctatt gatcttccgc ttccttttgc
     3301 acttgtctca ccgcccgtca atacaaaggc cggcctgtga tatttttccc tgatcctgcc
     3361 tgctataata ccggcaagac tttcatgaca atccggaaga taaactacca gtactctgtc
     3421 atttttcagc tctgtagtct ctatgatccg gattgcctct tcttttcctt tctcagtgag
     3481 agcttttcgg ctctgattaa gagctgtaag atctccggca agccttgctg cttcttcctt
     3541 tgtttttgca ttgagaagtg caagagaacg ggcagctgta tccagtctgc cactggcatt
     3601 gatacatggt cccagcacaa atccgatatg ataagctgtg attttagcat cttccagaga
     3661 atttgctcgg atcagttcct gcaatccttg atttttggta tttttcagac ggcacagccc
     3721 ttcttttacc agaatcctgt tctctccctg aagatccata acatctccta ctgttgcaat
     3781 agccgccagt tcataataat cttccagctc ctctgccgga acaccaaatc tctcgtaaag
     3841 tgctgcaata tatttaaagg ccaccactgc cccacacagg tttttattcg ggtatggaca
     3901 atcatattgt ttcggattca aaatcgcatc tgccggcgga agcaccatct ggcgttctcc
     3961 cttttcctcc ctgtaaggaa cctcatgatg atctgtaata atcactgtca ttcccttatc
     4021 ctttgccatc tggatttcag cagccgcagc aattccatta tcacaggtca cgatcgtatc
     4081 gatccggtcc gtttccgctc tttctataag atgtgcatga atcccatatc cgtctgcaac
     4141 tctgtccgga atataagtat ccacatctgc tccaatcctt gcgagacctt tcattaaaat
     4201 gtatgtagag gtcacaccat caatatcata atcaccaata atacggactt ttgctttctg
     4261 cgatattttt ttctccagga tatctacagc tttttccata tccttcatca gccagggaga
     4321 aggaagctct tgtactgttc ctgacagata ctctcttatc ttatcttctc cgatcacatc
     4381 tctgttcctg atcagtctcg caatcaccgg atcaatatga aactgttgac cgatctggtt
     4441 aaaatctgct ctttttgctg ctattaccca tttctccata tattttctct cctcataaaa
     4501 atatcccgga gttttacccc gggatatttc tgtctgcctg tttttcagac aattattgtt
     4561 ttattcagca tcatcattct gctgtttttt agctgcttct tcggcagcca gacgttcagc
     4621 tactcttttt ctgtttttct tctttggctg agtcggatct ttctgtgata catcacgtgc
     4681 tttcttcggc tttgaagagg actttgcaga tgcggaagct gcagcaattg ccggctgtcc
     4741 ttttcctgca aatttctttt tcatcacata ccacaacgca cctgtaatac atacagaaga
     4801 atatgcaccg acaagaacac caaccatcag aggtgctgca aattcacgga tagaagaaac
     4861 acccatgata taaagaacag ctaccataac aaaagttgta aaagaggtat aaatacttct
     4921 tgtaagagtc tgagtgatac ttgtgtttac aatttctgcc agtttttctc tggaaccact
     4981 gtgaaggttc tcacgtatac ggtcaaaaat aacgattgta gcattgatag aataacctac
     5041 gattgtaagc atgcaggcaa taaatgtatt accgacagat actctggcaa tagcatagaa
     5101 tgcaagtaca accagaacat catgcagaag cgccaatacc gcactgcttg caaaacggat
     5161 gtctttaaat ctgaaccaga tataaagaag catacagatt gtagctacta taacggctac
     5221 gatcgcatca cgacgcattt cactacttac tgtagaagaa atactttctg tggaaatcgt
     5281 gctgtcatct acaccaaatt tctcaaccag tgcactctgc agagcttcac gttcgctctg
     5341 attcagagaa cgtgtcttga tcacaacctg atttgttccg actacctttg taggctgaac
     5401 atttttatct cctgtcacct cttctacaac aggagttact tcagaatcaa tggtcttaat
     5461 atccatatct tcattaaatg taacagttgt agaagtaccg cctgagaact caaggctgta
     5521 atttaacgct ttgtttcctg catgcgaatt agcaaacatc gctgccggac cgcagaggat
     5581 caggataatg gaaatagcaa aaaatacttt cttctttcca aggaaatcaa ctgccttacg
     5641 ttcttttgca gatccgtaga atttcggatc acgtacacca actgcataaa gtgcatttac
     5701 aatcagtctg gatacaacca gtgctgtaaa catggagatc acgataccaa gggcaagtgt
     5761 ataagcaaat cccttaacag tacctgaacc aagccacatc agcacaaagg ctgcgatcag
     5821 tgttgtaata tttccatcaa agattgcaga gaaagctttg ctgaaaccgg acttaataga
     5881 attccttact gaaactcctg caccaatttc ctctctgatt cgggcataaa taataacatt
     5941 ggcatccacc gccataccga taccaaggat aatacccgca atacccggaa gagtaagagt
     6001 aatatcaaag gcattcagcg tgatcagcat taatgatgta taaagaatca gtgcgatacc
     6061 tgcaactaca ccaggtacgc ggtatgcaat gatcataaag ataataacga tgatcagacc
     6121 gatcgcacct gcaagaacac ttgtagagat tgcttcttca ccaagctgtg cagctacaac
     6181 actggaacga agttcttcca gttccagtcc cagagaaccg atacggatat aagaagcaag
     6241 gttctgtgct tcttccaggt cagacattcc gctgatctgt gcttttccgc cggaaatctc
     6301 ttcatttaca ttcggagcac tgataatgtt attgtcatag acgatagcga tctgcttgcc
     6361 tacattattc tttgtagctt ctgcaaattt tgttttacca ctgttttctc catcagaagt
     6421 aagagtaaga cttaccacat attcctttgc acttgtgttc tgattctgga tcgcaccacc
     6481 ctgggcatct gctacatcag aaccttccag aacaacactt ccggattcct tgatctcatc
     6541 catagttctg gagagaacat atccatcctg tcctgtagta aagttctggt ttccgtcagc
     6601 atcttctttt gtgatgaaat acagggaacc tggtttaccc agatcattca aaatagtatc
     6661 tgcatctgta acaccaggaa tttcaactgt aatacggtct gatccttcct ggtatacctg
     6721 agcctcagta ctgtactgct ctacacgctt ctgaagcttg tagatcgtat ctgacatctc
     6781 ttcgcttgtc ggattgctct ccttagcctg gtaggtaatg ctgacaccac cggcaagatc
     6841 aagacccgtg ttgatatgtt ttgctgcacc ggttccggta ggaccgatac ctacggctgc
     6901 agtaaagcaa aagaacacag tcaggatcag tgtcagaagc agcactacga ttcctttact
     6961 tttcttcata gttcttttcc cttcttgatt ttttgtccgc ggtcatgttc atccgcctgc
     7021 cagccatttt ctgttatgat aacagccgac ggcggtatca gtcagacaga ttactgccca
     7081 ctaatcacat gccagtgcgg cttttatcat gatggcgcac tccacacgtt ttctctggag
     7141 ttcgcatccg atttcataat tgcctttgat atctccctgg aaatggaatg catttgccgc
     7201 acatccgcca ctacagtaga aacgtgcgaa gcagtctttg cagtctttct ttgtgtaaac
     7261 gttgcatccg ccgaattcct tctggatttc cggctttgtg atgccttcgt ctacatttcc
     7321 catgagatac tgttcttcac caacaaactg gtgacatggg taaaaatcac cccagggtgt
     7381 tacagccagg tactctgttc ctgaaccgca gcctgacagt ctcttgtata cacaagggcc
     7441 acctgtaagg tcgatcataa aatggaagaa gttaaatcct tttccctctt tctctctttt
     7501 aatcatttct tttgcaagag tatcatactc ttccatgatc tgggggatat cctcctcgcg
     7561 gatcgcatat tcctccgtat cagccgcaac tacaggctct acagaaatct gtttgaatcc
     7621 aagatctgcc agatgaagca catccttgga gaaatcaaga ttatggtgag taaaagtacc
     7681 tcttacataa tacttgtcct gatttctgga ttctgcaaac ttctggaact tcggcatgat
     7741 caggtcatag cttcctgcac cttttctgaa tggacgcatg taatcatgta cttccttacg
     7801 tccgtccaca ctcagtacaa cgttgcccat ctctttattg cagaattcca ttacttcatc
     7861 attcagaaga actccgtttg ttgttaaagt gaaacggaat ttcttattgt gaagcttttc
     7921 ctgctctctg ccatatttta ccagatcttt tacaacctgc cagttcatca gcggctcgcc
     7981 gccaaagaaa tctacttcca ggttttttct ggaaccggag ttcgcgatca ggaaatcaag
     8041 agcttttttg ccgacttcat aggacataag agctcttctg ccatgatatt cgccttcttc
     8101 ggcaaaacaa taacggcagg ccagattgca gtcatgagca atgtgcaggc acaatgcttt
     8161 tacaacggtc tgccggttat ttgaaaattc ttcaattaca ttctcataaa catcttttgt
     8221 aaaaagcatt ccatcttctt tcagcttatt acattctctt acagatgtct caatatcttc
     8281 tctgttatat ttgttttcca gtttctctgc aatagcttct gtgccaaggc cctcttccag
     8341 atatggaaga acctcatatg taacctcatc taccagatgg atgcatccac tgttgatatc
     8401 cagtacaata ttaaagccat tgcttttata acggtgaatc agactcattt tactaaaatc
     8461 ctttctaagc gtaagataag cagcggaata aaagttccgc tgcttatctc atttctccat
     8521 agctgatctt atttctgctc gcagctctgg tttcctactg tacaggaagt tttacatgcg
     8581 gactggcagg aagtctggca ctcgccacat ccaccttttt ttacagtgtt ctgtaaattc
     8641 tttgtattca gggttttgat atgttccata actctatcct ccttatgtaa ttatattctt
     8701 ggcatagtat atcatatatc ttttcatttt aaaagctttt ttttacgaca gcattccacc
     8761 cagtgttcca ccgcctgtgc acataaaaaa tgttgtaact gcatgagctg cactcatatc
     8821 ccagccgcct tttgccataa tagagacagt caacagtaat acatagtaag ccagacctgt
     8881 gataacaccc cacagatatt tgtctttacg cacaattttg ccggccataa agcctcccat
     8941 gaaacatgca agtacataaa ttataataat acccgcatct acagctgttt ctcccagatc
     9001 aaaagcaaac agtaccaggg ccaaaagcag taatgccact cctgttaatg catatgcaaa
     9061 taatagtgat ttcaaaattg ctctgacttt cattgcttcc cctcctgtta aactatatgg
     9121 gggaggaatc agtgttattc ttttatttct ttctcttttt tataaataca gccacaccgg
     9181 cgatcactgc agctgccaca aacagtatca caaacggcat aattgatgtt gtatctccgg
     9241 tatttactgt attgttattt ttcacagctt tattttccgt tgaattatca ttctgatcag
     9301 aagaagaacc attattgctg tcagaactgt cattcacaga tactgtattg ttctttccgg
     9361 aatcagagct ctgactgtcg gaggaagccg gtgcaggagt taccgcatct gtgtcgtccg
     9421 tatcattccc cgcatcaggt cctactaatt gtctgcttcc tgcaattcca aatggactga
     9481 aagaatgtgt gctgaatacc ataataccat tctctacact cggaataatc gtctcagttg
     9541 ccccgttgtc caggagatgt tcgatagtat actgatatcc ggattttacc ggcacagtga
     9601 cactgatata atctccatta gggatctcat attctgtatt attcttaaga tcccagagtt
     9661 caaattcata agactggaaa atcattgcat ctgattcatt ggtaaactga tagctgtcac
     9721 cgcttgaaac tctgaactgt acataccatg gaagattaac tccgcttact gtaataccgt
     9781 cgcaggtatg attaagtgcg gccctctctt ctttttcttc atcagaaaga gaatcctctg
     9841 catctgtagg acggtcatcc ttatcgtccg gcagaacagg attatcaaag atattatcat
     9901 ctgcgccatc ttcatcatct ttcttcgtat cttctttatc ctgtgtcata tcatctgcag
     9961 gttccagctt accggtagtt tctgtatctt tatccgtctt atctgcattg ctgttattat
    10021 ctttgttgtt tttattatct gttttatctt cttcaatctt attctcttca ttgtctgtat
    10081 cagttttatt atcctgatct gatttacttt ccttatcttc tttattgtct gtatcagcgt
    10141 tttcatctgc ggcaggtttt tctgacgaag tttcaggcgt ttctgttgga tctgcatttt
    10201 ctgttggatc tgttttacct gagccttctg tcttatcaac attatcacta tccgtaatac
    10261 tgttcactat tacattgatg taaccgacaa ccgcgccgct ctccggatcc catccatcca
    10321 catggcttaa atcctgccct tctgccggta taagaagtac ctcacagctc tgtacacgct
    10381 gtgcaggaac gaaacttcca tctgcccatt caaaagttcc atattccgtt gccggaagtt
    10441 ctacatccgc aagttctaca ggcttatcaa gcgtaatgtt gtccgggatc agagaagaca
    10501 cagtattctc ctgtgactca gccgcactga cctgtcttgt tacacccggt atattatttc
    10561 ctgcaatcaa agccgctgtt aaagccgctg ccgcaaaaat acccgttcct tttaatttat
    10621 tttttcttat tcttatatta ttggacatat cgcacctcta tatttatatt cgattcttat
    10681 gtttcctgat aatcattttt ttactttcag ccaaatatca gttctctttt tacgtaatac
    10741 aataatatta catatctgta tattatcaaa cttttatcat tttgtaaata ttctgtaatg
    10801 ttttttttca ttttaatcga gtgaattata acacaaatct tactttttcg acagtcctct
    10861 tttaaatttt tttatactat ctttgaacca aaagcttttt cttgattttt tatatgaaat
    10921 catgtatatt ttgcttaaat gttttatgat atgattcaat caataaagat aatcaaaagg
    10981 agtgaataaa tcttggattc aagtattgcc tttcaggcgg tggcgattct gatactgatc
    11041 gcactttctt catttttttc ttctgcggaa accgctatga caaccgtaaa taagattcgg
    11101 atacagtctc ttgccgagca gggcaacaaa cgtgctgtta ttctggaaaa aataatttcc
    11161 aattccccaa agatgctcag taccgtatta atcggaaaca acattgtaaa tatgtctgtt
    11221 tcttctctca tgactacact caccataaag attctgggaa acgcatatgt aggaatcaca
    11281 accggcatcc tgactctgct gattctcatt ttcggtgaga taacccccaa aaacctggca
    11341 acaattcatg ctgaaaaatt gtccctggcc tattcaagaa taatatacgg gcttatgatt
    11401 ctccttactc ccgttgtttt cattgtaaat aaaataacag aaggtgtact ggtcattctg
    11461 catgttaacc cggacgaaaa ggcaaatgcc atgactgaac atgaactgcg taccctcgtc
    11521 aatgtaggtg aaaaagacgg cgtcattgaa aacgaagaaa aacagatgat ctacaatgtg
    11581 tttgattttg gcgattcaac tgcaaaagat gtcatgattc ccagaatcga catgaccttt
    11641 atagatatca atttttccta tgatgaactt atggcggtct tcagtgaaga tatgcatacc
    11701 cgttttccgg tttatgagga caacactgat aacgtaatcg gtattatcaa tatgaaagat
    11761 cttcttgttt atccaaagga caaacctttt tcaatccgca acatcctgcg tgagccttat
    11821 tttacctatg aatacaaagc tacagcagac ctgatgattg aaatgcgtaa agcatccgtc
    11881 aatctggcaa tcgttctgga cgaatacggt gccacagcgg gtctggtcac attggaagac
    11941 ctgttggaag agatcgtagg tgagattcgc gacgaatacg atgaggatga agtcgaagat
    12001 attaaagaaa tccagcctga aagagaatat gttgttcagg gttctgccaa gctggatgat
    12061 atcaacgaag ccctccatat taatctggaa tctgaagatt atgattctat tggcggatat
    12121 attattgaac agcttgactg ccttcccaaa gagggtcagt ctgtcacact tgaaagtggc
    12181 atccgcctgg ttgttgaccg tctggacaaa aacagaatcg aacttgtcca catctggctt
    12241 cccgagaaga aaactgaaac agaagaacag ccgtaactgt catctctcca gcatcagtga
    12301 aaattgtttc acgattctgg agagttctcc tgtaaccgca tcaattcctt cttcgttctt
    12361 tctccagttt tctctggtaa ttccatctgc attcacaggc accacataaa attctgtttt
    12421 cggatacaag agctgataat acatcagaca tcttcttgca tggtaagatt tgcagcacaa
    12481 aatcgctctt tctatttcca gttctgcatg atctgtcacc tgtctggaat aaattgcgtt
    12541 ctcataagta aaggttgcct ggtcttcttt caggattttc tgatccggaa ctccgttttt
    12601 tataagaaca tccctgagaa attcccattc tgttccatat tccttatcat atacattgct
    12661 tttttcaaga acgcctgaaa actttccatt tactacgctg tattttccac tgggcagaat
    12721 ccagtccgcc atccctttct taaacaattc tgctgctttt tccgccatct gcggataacc
    12781 atttccaggg acaaaaataa tatcagattt ttccggcttg ttttctgcaa aaataaactc
    12841 ttctgaactt tttaaaaatt tttcatatac gtcattcatc attactaact cctcgttatc
    12901 tgttttttct acagcacctc tcaaataatg cgtttgtaac agtccaacaa aaattcacgc
    12961 tctgatgaac cggaacaata tgcattattt acgaagattt ctatggaatt tctatagata
    13021 gatacagtgt accatatttt ttctattaac gtacaaccaa gttaattctt aaaactatgt
    13081 cccccactgc ttatgttact gttcactctg ttcacagcaa cacgcttcgc gatgcacaga
    13141 cttccaatat ttccagaagg ctattttgtc acaataaccg tactgtaacc atcatccctc
    13201 agtctctgct ccatatttac tgcattacca atctgctgat aggcacctgt ctgaacttta
    13261 tacaatccgt tttcatgtaa cataaaagag ggataacctt tttccagtaa ctgatataac
    13321 atacggtccg cattctcttt ttttctgaac gctccagttt gcactctgta ataaagcggt
    13381 tcctgcactg tttcctcatc caggcttcca agaatcgcat ctgcaattcc ctgagctata
    13441 tcgctaaact tgttatcaaa cagtttatta tcttcttcgg aattgataaa tccggtttct
    13501 attaaaagag ccggcatcct ggttcgtctg aggaccacaa gtcccggccg ctcttttaca
    13561 ccgatttcgc ggaatcccac ttctcccaga gctcccagaa tattctcagc catctgatat
    13621 ttaatcccgc ttttatcata aatcaaaact tccgctccat tatactgatt ttcct
//
