LOCUS       c00015_gnlPro..        15374 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPBLLOKO_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:35:51
            Original ID  :: gnl|Prokka|EPBLLOKO_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15374
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15374
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[68:8479]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      69..8479
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15374
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15374
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(5..130)
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKVWRNLMWSEILTESVKSYMDCKCLNAISI"
     CDS             complement(69..1586)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_2"
                     /sec_met_domain="Fer4_7 (E-value: 1.5e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.8e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 7.2e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTVM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPDCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFRASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             complement(1852..2616)
                     /locus_tag="ctg15_3"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIAAVCMFSDVHGAEVAGPPAPKSKSALT
                     QKPEATPIPASTPTPEQETETDKQNPADQGTLSKPDHPDTISADKLVFIGDSRTEGLRD
                     AVNDDSIWSCLSSMGYDWMVSTGVPQVEDQIEDNTAVIILMGVNDLYHVNDYISYINSK
                     AAEWGNRGAQTYFVSVGPVQNDPYCSNAEIESFNAAMQASLSGVTYIDVYSHLVSEGFS
                     TVDGTHYPDSVSVDIYNYILDHLEEQMSGIWG"
     CDS             complement(2594..2722)
                     /locus_tag="ctg15_4"
                     /transl_table=11
                     /translation="MAGYAAWDVSMLLFTATHSRELRYVKSNVSITAEGNDIYEKI"
     CDS             complement(2695..2949)
                     /locus_tag="ctg15_5"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             complement(3619..5259)
                     /locus_tag="ctg15_6"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYADQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             complement(5261..6379)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_7"
                     /sec_met_domain="PAPS_reduct (E-value: 2.9e-65, bitscore:
                     209.7, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVVAGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKKNGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             complement(6410..6724)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_8"
                     /sec_met_domain="Fer4_9 (E-value: 2.2e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.3e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.3e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             complement(6721..7533)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_9"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 3.6e-09,
                     bitscore: 26.9, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPSQTLKWMEAGKGPSEENVEIEGTEPYIVGGHTASGYWVDNNR
                     ATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGKDDDRIAAENKEEALER
                     GGEQELSQTAIAKKAEYESHLNASRSLMNAEQLEEAMQKIMDQYAGGIGTDYRYSGMSL
                     AKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVIAHLAARKETRWHSFGEN
                     TDYPQQSEEWMKYVNSRMENGEIKILYRDLITKENTGLNTAEKGAGER"
     CDS             complement(7481..8479)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 63.4; E-value:
                     6.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_10"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.9e-20, bitscore:
                     63.4, seeds: 62, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYXXXXXXXXEYGTVPDSEMDGSRKRTI"
     CDS             complement(8591..9649)
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVERVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             complement(9651..10475)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60; E-value: 8.2e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_12"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.2e-19, bitscore:
                     60.0, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVGISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGIKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             complement(10475..11311)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 82.6; E-value: 9.7e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_13"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.7e-26, bitscore:
                     82.6, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     IIETITRARVLASFYTSFVCAFAAAVINGIMGTVLAWVLVKYDFPGKRLMDGMIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSKLQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             complement(11382..12380)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 56.8; E-value: 1.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_14"
                     /sec_met_domain="SBP_bac_1 (E-value: 3.3e-18, bitscore:
                     56.8, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSVTNVSYDPTREMFEQYNK
                     IFEDHWKEKTGEDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             complement(12583..13071)
                     /locus_tag="ctg15_15"
                     /transl_table=11
                     /translation="MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFH
                     ELTFMGPIAFILDFFIIGGLAKKIAFGIVDMRRDNPFHLVLAISAVSVAFMCPCMSFAA
                     TVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE"
     CDS             complement(13525..14073)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BMC"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_16"
                     /sec_met_domain="BMC (E-value: 1.4e-14, bitscore: 44.2,
                     seeds: 429, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDVHKISTNCTRNEFVGTAVLDTIGLVISGIDDTLLETMNVGMK
                     YRCLGLFSSRTGAAGQITAIDDAVKATNTEVLSIELPRDTKGWGGHGNYIVLGGTDVSD
                     VRHAISMALELTNKYAGELYISESGHLEFAYSASAGQALNKAFGVPXXXXXXXXXRACD
                     GRYCDEISASFHCEIYDAE"
     CDS             complement(14449..15372)
                     /locus_tag="ctg15_17"
                     /transl_table=11
                     /translation="RKLFVVEFIFLHYTKSKEFFCFGKDRRMETRKFKDLTIRDAFMFA
                     AVMSDPEICRRVLELALGIPISEVHIQTEKTMAYHSEYHGVRLDVYAADADRTRFNVEM
                     QVTLQKFLPKRSRYYHDQIDMDALLAGDSYENLPDTYVIFICDFDPFGDGLYRYSTGMV
                     CEETGKSVSDGVKTIYLNAHGRNREDIPEELLQFLDYVKNTGRTEGISTTDPFVRHLQD
                     SIDKIKQNRGMEERYMLLEEMMRNEKREGNTEGKQEFLLTALESKFSVPSELKEKIMSE
                     TDIEKLNLWFQLSLKVSSLEEFEQNM"
ORIGIN
        1 tctgctatat actgattgca ttcaaacact tgcaatccat ataggatttc actgattcag
       61 tcagaatctc actccacatc aaatttctcc agactttcca gtcttgctct gtatttggag
      121 tcataggcat ctgtaaacga agcctctttc ttcatttttt cgagagccgc tgctgctttt
      181 ttaactgtct ggatagtacc ggcacctgct acacagccgc ccggacatgc cattccttcc
      241 agcagatatc cattatattt accaatcttg gccatctgga gcatcttctt acagttctgc
      301 agaccttctg cattcattac ctttacttcc cgatcaggat caatacgctt caccgcatgg
      361 acaaccgctt ctgccacacc accgctgact gcgaaacctc ttccgtcagc actggcacga
      421 aacagtggtt ctccttccgg aatatctttc cagtccacgc ctttggcatc aaacattcct
      481 gctacttcct cgaaggtcag cacaaaatcc acatagctgc ggatactctt acggctggct
      541 tccagcttct tggctgcaca gggacctacg aaaacgatct tacaatctgg ttccttctgc
      601 ttgatcagcc ttgcagtgag aaccataggt gtcagtgcca tggagataca tttcgcctgt
      661 tccgggaata atttcttagc catcatagac caggacggac aacaggatgt agccataaac
      721 ggaagtttct caggaacttc ttccaaaaag tcctttgcct cctccactgt gcacagatct
      781 gcaccgacgg caacctctct tacatctgta aagccaagtg cctgaaatgc accccgtatc
      841 ttattattct ccatacctgg gaactgacct gcaatggcag gcgccacgat tgcatacacc
      901 ggtgtttcac tttttaatgc cataacagtc tggaaaatct gtcctttgtc tacaatagcg
      961 ctgaacggac aactcaccag acactgtccg caggatacac atttgtcttg gtcaatctcc
     1021 gctcttccgt attcgtcaga accaatggca ttcatgccgc aggcctttga acagggacgt
     1081 tcctgtttga tgattgcatt atacggacag gcttccagac actttccgca tttgatgcag
     1141 gcatcttcat caatatgtga tctgccgcct tccatatgta ctgctttctt tggacagacc
     1201 tccacacagg gatgctccag acagccctga cagccctctg taatcattac ccttttctca
     1261 gggcaggaat tacaggcaaa cttgatcaca ttgataagcg gcggttcata atacttttcc
     1321 tcaataacgc tggcctccac acctttggag attggcgcat gctctgtaac ctttctcagt
     1381 gacatcccca ttgcaacgcg aagtctctca ccaactaccg ctctttccag aaaaatactg
     1441 tcacgataag tcgcaatttc accgggtacg atcttgtagg gaagctcttc cagcatctcc
     1501 ggagactggc cttcatatgc catcctcgca atttctgtaa aaattttgtg tctgatttct
     1561 gttttggatg aatacagtcc tctcattttt tcctcctgat tttcgattcg gataactgta
     1621 cggcaatcca atgcagggac accgaacaat ttccatttat aatttcatca ctgctgcaat
     1681 cagcacactc atttttcctc ctgctgaact ttcagccact tcacagagaa acgaaattcc
     1741 gctcatttcc gtttccttat ctgcatatca tatcaccaaa tgcttccagg ctcaacacaa
     1801 catcagaatt ttcgctgaat tgtcgccccc gaagttgctg ttcatatgtt gttatcccca
     1861 gattccactc atctgttcct ccagatggtc caagatataa ttataaatat ctacagacac
     1921 actgtccgga tagtgggttc cgtctacggt ggaaaatccc tcagatacca gatgggaata
     1981 tacgtctatg taggtaactc cactcaggct tgcctgcatt gccgcgttaa aactttcaat
     2041 ctccgcatta ctgcaatagg gatcattctg caccggacct acagacacga aataagtctg
     2101 cgctcctctg ttcccccatt cagcagcttt ggaattaata taactgatgt agtcattgac
     2161 atgataaaga tcattaacac ccatcaggat aataaccgct gtattgtcct caatctgatc
     2221 ttctacctgc ggcactcctg tagataccat ccagtcatat cccatagaag aaagacagga
     2281 ccaaatgctg tcatcgttta ccgcatccct caatccctct gttctggaat ctccgataaa
     2341 taccagttta tctgcggaga tagtgtccgg atggtctggc ttgcttaaag ttccctggtc
     2401 tgccggattc tgtttatctg tctcagtttc ctgctccggt gttggagtag atgcaggtat
     2461 tggtgttgct tcaggttttt gtgtcagtgc cgatttggat ttcggtgccg gcggacctgc
     2521 cacttctgcc ccatggacat ctgaaaacat acagacagct gcaatacatg cggttaatac
     2581 gatttgtccg gttctatatt ttttcgtaaa tatcattccc ttctgcagta atacttacgt
     2641 tacttttcac atatctcaac tccctggagt gtgttgctgt gaacagtaac atacttacat
     2701 cccaggcagc atatccggcc atgagaggat ttctccggaa ataatttcct cgtaatctcc
     2761 ctcaatatcc tggcttctgc ctgcttcgaa cacgtttgtc tccgctcccc agacacgatc
     2821 ttcatattcc catatatgga atctcagacc gcgaaacata aagtcgatgc ttccgcatcc
     2881 gttttcctct gtatattcat aatgaatttt ctttgttttt aacgcttcct gtactttttc
     2941 caaacgcata aaatacctcc tgattatctg tacagtaccc tctgtaatat aatacagata
     3001 actttcactg taaaaaaatg ttctcgtgta cacccatcaa aagtcaaaca gatattcgca
     3061 atccgcttcg ctacacagct ctacatatgc tcttaatcct gacgccatta tacaaaacga
     3121 attatatcat actctgctgc ataatatgta atctgaatgc cacttcacaa ttgccgttac
     3181 tgttcactcc gttcacagta acttagccaa aattcattcc agattgcctg tggcaatgga
     3241 attttggctt gtatgtctcg ggattttggc atattcatgc caaaacacct cgcgggataa
     3301 tggtgtgtga acagtaacca attgcccatt ctacattctg atcgatattc actcatcttt
     3361 atttctgtct tttcttcgtt ggtatcgcca ggatgatgat cgtagcaatt acaaacaaag
     3421 ttccaagcat catctctttt tttggttttg tttactttca ttgttcgttt gcatatttct
     3481 gttatctttc ctgtctgtat tattatggat tctgaatatt tgaaaataag tataatccgc
     3541 tgtaacgaca cttgtcaaga aaacaaaata ccgcagagac tttctttgtc tctgcggcga
     3601 tttatagccc tgttataatc agatataatt tccatcatgt acactctgca ctgtaaatgc
     3661 agatttcttt ttcacgaaat caatcgcatc tttcacagtg attccgtcaa tctgccagtt
     3721 cgcatagaaa ccatccagag tctttaatgt ctcgtctttt gctgtatttt catcaagaac
     3781 aagaagtacg atcagacctg ctgccttaag atggcggaca gtttctgcat agttttcact
     3841 cgctgccgga tgatacagat aggtatgttt tccaagtaca gtcagtccct tttctacctg
     3901 ctctgcaaaa tcaagagtga ttccttcttt accgatcggg aattccacta ctaccggtgt
     3961 ctgacctttc agtcctgcac gaacctgctc gtccactttt ccgatctggg atctatcctg
     4021 agaaacaaag gtttttctca caacaccgca ggcagaagtc atatttgtga cacgatctat
     4081 cagaatcagc tcacccagtg ttctgtgcct gtcaaattcg tctacaacga tcttctctga
     4141 gaattccaga gtacaggaag caatctcatt tttctttaag gtatatgcgc ttttcttttc
     4201 acctgtatta acatccacag aataattgat ctttgtaacc aggccgggga tcatctttgt
     4261 accgattttt acaaagaagt ttttgccatc cgtaagagca ttgtcatcca tccagaggat
     4321 atctgcttcc acagagtctg taagaactgc gccggaatca atggtaagta cacatccgcg
     4381 ggaaacatct acttctctgt caagctggat ggtaacaggc tgtccctgta cagcttcctg
     4441 aacttcttta tcgccaacaa gaatactctt tacatgagct tcttctttac tgggaagagt
     4501 agtcacaagg tcgcctgccc tgatggcacc attctcaatc tgtccctgga atccgcgaaa
     4561 ctcatggttt ggtctgcaga ctctctgtac aggcatatag aagcccttct ctgtatcttc
     4621 cttaatgtct acggtttcca gatgggaaag aagcgcctca cctttatacc atggcatgtt
     4681 gtcagatttg gttgtaacgt tgtcaccttc tgtggcagat accggaataa tagttacatt
     4741 ggcaagtttc agttcttcta tcagtgctgc gatctgattc tcaatgtcgc ggaaacgttt
     4801 ttcatcatat tcaataagat ccattttgtt tactgcaaat acaaagtaac ggattcccat
     4861 caatgcgcag attcttgcat gacgtcttgt ctgtaccagt actccctgtg aagcatccac
     4921 caggataact gccagatctg caaaggacgc acccactgcc atgtttcttg tatattcttc
     4981 atgtccgggt gtatctgcaa caatgaagct tctgttatct gttgtaaaat aacggtatgc
     5041 aacatcaatg gtgattccct gttcacgctc tgccatcaga ccgtccagaa gaagagaata
     5101 atcaatggca ccgcctctgc ttcctacttt ggaatccagc tccagggctt tctcctgatc
     5161 tgcatagaga agctttgcat cataaagaat atgtccgatc agagtggatt ttccatcatc
     5221 cacacttccg catgtaataa atttcaataa tcctttcatt ctagaaatac ccctctctct
     5281 ttcttctctc catgctgcct gctgcctcgt ggtcgatcac cctgctggta cgttcagaag
     5341 aaacagcact taacgtctca tcaataatct catccagagt atctgcttca gattcaatac
     5401 ctccagtaag cggatagcat ccaagagtac ggaatctgac ttttttgttt tcaatctttt
     5461 cacccggacg gagttttaat ctgtcatcat ccaccataat gatatttccg tctctgtaga
     5521 tgaccggtct ttctttcgca aaatataacg gtacaatttc gatattttca cgctgaatgt
     5581 actgccagat atccttttct gtccagttgg aaattgggaa tactcgcata ctctctccct
     5641 tctggatctt agtgttataa agcttccaca tctccggtct ctggtttttc ggatcccatg
     5701 cctgagctga attacggaaa gagaagattc tttcttttgc tctggatttc tcctcatcac
     5761 gacggccgcc tccaaatgcc gctgtaaatc catatttggt cagagcctgt tttaaggcct
     5821 gtgttttcat gatatctgta tatgcagaac cattgtcaaa tgggttgatt cctgccttta
     5881 caccctcttc attggtgtaa accagcatat caattccgtt tttctttgcg attctgtcgc
     5941 ggaattcgat catctcatgg aatttccatg tagtatcaat gtgaaggaac gggaatggag
     6001 gtttctccgg gtaaaatgcc ttcatcgcca gatggagcat aacggagctg tcctttccta
     6061 tagaatagag cataaccggc ttttcacact cggctgctac ttctcgcata atataaatcg
     6121 cctctgcctc aagcgcatca agatgagata agttactcat tgcattatcc tcctctgttt
     6181 gtttatactc ggaatctttt cgtacttgag caaatacact agagcgtgtc tgaaaaatca
     6241 ttcccgcaat ctgcacgccc cactttgcgg tatattttgt ccgaattcgg ttgtcgtagc
     6301 ccgctacgac gccctcatcc gaacaaaatc tcccacaaat tgtgacgcac atcttgcgta
     6361 aagcattttt caaacacact ctaaagactc tgagagtaca tacttatgtt taatatttat
     6421 tagcgtcttt cttattaacc tgaatagtga tcttagtgcc atccggcttc tccactgtcc
     6481 atgtggaaat atccggtttc tctgatacaa ccatacttgc acctctgcct cccacatcag
     6541 ctccaaggaa aaagcggatg gcatcatgcc tgcattcctt aatacaggaa gtacatcccc
     6601 agcagtctct tacctgacgg ataaaggctt tgttctcttt atcctttttg atcagatttc
     6661 cgggacaggc ttcgatacat ctgccgcatc ctgcacattt acttttctga atccgaatgc
     6721 tcatctctca cctgctcctt tctctgctgt attcaaacct gtattttcct ttgtgatcag
     6781 gtcacgatat aagatcttaa tctcgccgtt ttccatacgg gagtttacat atttcatcca
     6841 ctcttcgctc tgctgcgggt agtctgtatt ctctccgaaa ctatgccatc tggtttcctt
     6901 tctggctgcc agatgtgcga tcactgcctg gcacacgatc agtcgttcgc gaagttcata
     6961 aatctgcatc agttcataag tatctgttgc tgccagagtg tcaactactg gcaacaatgc
     7021 tgcgatcttt tcatctgcct ttgcaagact catcccgctg tatctgtagt ctgtaccgat
     7081 tcctcctgcg tactgatcca tgatcttctg catggcttcc tcaagctgct ctgcattcat
     7141 caaagaacgg gaagcattca aatgtgattc gtattctgcc ttcttagcta ttgcagtttg
     7201 agacagctcc tgttctccgc cacgctctaa agcctcttcc ttattttccg ctgcgatccg
     7261 gtcatcatct ttgccattca gatattccaa aatcgcctct gctgcgatct caccttctgc
     7321 cagtgcgccg gttacatatt tctgcggaca tcctcctgct acgtctccgg ctgcatataa
     7381 accttcaata gttgtagctc tgttattatc tacccagtaa ccgctggctg tgtgtccgcc
     7441 cacaatatat ggctctgtgc cctcgatctc tacattctct tcagatggtc cttttccggc
     7501 ttccatccat ttcagagtct gggacggtgc catattcnnn nnnnnnnnnn nnnnnnnnnn
     7561 ngtaaaggtc ctgctcctgt tctttggaaa taccttccgt tctgagataa catgggccgt
     7621 ttccttctct gttctccatg actgtaccgt aaactcgctg ggaagttgtc agaccatatt
     7681 ttgtttcata aatatcacca tgtgcattga cctgtctggc cccaacaccc tgagcaatag
     7741 ttcctgtagg agcaatcgtg tccttacatc tcaatgcaat gaaacgcatc tcaaaggttg
     7801 tcatctccgc accggaaaga agtcccattg catatcctgc acctgtgtta aacggaggat
     7861 accacatctt atgtctggaa aatcccggat tattcggtct gtaaagtccc gctgcaccac
     7921 ctgtggcaca aagaactgct ttcgcatcaa tgtcatagaa aatatcctca ttaacgctaa
     7981 atccaactgc gcctgtgact tttttgtttt ctgttttata atctgtaata tttacatgat
     8041 tgagaaccgt aacattctcc tgttcagctg ccgcctttgc aaggattggc ttcatatttt
     8101 cgccattgat cttgatgttt cggtttcctc tggcaacata ttttccgttt tcgtccttca
     8161 ggatgaccag ccccagatct tccatcacct ttgtcacatg attcagtctc tctgacatgg
     8221 taagaagaag gtcttctctt acgattccat gggcatcctt tttggcataa tccacataat
     8281 cctgcggcac tctgccttct gtaatatatg cgttcaatgc attcacgccc gccgccagac
     8341 atccgcttcg cttaatattc gctttctctg cgatcagaac ttttctgccg ctttttttgc
     8401 cgatcacata ggctgcaaag catcctgccg taccgccgcc gatgatcagc acatctgtcc
     8461 tgattctctc tgttctcatt ctctcttacc ctttcctcca taccagtgtg ccaacaagtt
     8521 gatttcccga tcagtcttgc gtctgaattt cttatttctt cattgtcgtc agtcgccgca
     8581 gccaccgctg tcagataatt acaaagtcat cccttacagc ctcattttcg atcagctgta
     8641 cactgtcacc tctcagtgca aaaatcctgt aaaggaatac attcacagtc tcaccttccc
     8701 ggatatctgc tttctccagg cttcttctgg cagttactac ggaattgttg actctcacct
     8761 gaagttccag attatctccc ctgaaagaaa cccgttcaac cactccccgg gatacggaag
     8821 ttttgaactt ctccacctca tccagtttgg agatttttac aaattccggg cggacaatga
     8881 tcttgtctgc tccttctgcc tgagcaaagg tatggaaatc atccgcattt ttcaacacag
     8941 atggctgtcc gaagaaggac gctgtaaaag ctgtctcagg atttctgtaa acccctatgg
     9001 gagttccttt ctgttcgatc cgtcctgcat tagtgataat aatctcatct gctacttcaa
     9061 tggcctcatc ctgatcatga gtaacgaaaa tactggtaat tcccagcttc ccgatcatct
     9121 cttttaacca gcttcgcagt tcctgacgga tttttgcatc aatggctgca aagggctcat
     9181 ccagaagcag cacctgggga tttggagcaa gggctctggc aaatgccacc ctttgcctct
     9241 gaccgccgga taactggctt ggatatcttt tttccagtcc ttccagcccc accagtttga
     9301 tcagctctct gactctggca tcaattttct tcttatcagc cttctgaacc ttcaaaccaa
     9361 atgcaacgtt gtcataaact gtcatatagc gaaacaacgc ataattctga aatacaaatc
     9421 caatcccacg ctgactggcc ggaacatcat ttaccacttt tccatcaata atgacctctc
     9481 cgctgtccgg ggtttccaga cctgcgatca ttcgaagaat agttgttttt ccgcttccgc
     9541 ttggtcccaa cagaccaatc agtttacctt tctcaattcc gaaattcaca ttccttgatg
     9601 cctggtaaga accatatgtc ttattgatat tttttaactc tacatacata tcaggcttcc
     9661 ttctttcctt tatattcaat caggcttctg actaccagaa tgataactgc catgatcaca
     9721 agcagcgaag atacggcaaa cgccggaaca tactgaaact cattaaacaa aatctctaca
     9781 tgaagaggaa gtgtattggt ctttcctctt aaatgtccgg aaagtacaga taccgctcca
     9841 aactctccca ttgctcttgc cgtacagagc acaactccgt acagtaatgc ccatttgata
     9901 tgagggaatg tgatcttcca gaaaatggtc catccacctg ctcccatcag ggctgccgct
     9961 tcctcctcat cgcttccttc tgcttccaga accggaatca gttctctgga aataaaagga
    10021 aaggttacaa atacagttgc aataatgatt cccggtacag agaatacaac tttaatccct
    10081 aacttcatga gaaaaaagta aacaggactc tgtcgtccga aaatcagaag aaagatcaaa
    10141 cctgcaataa caggggaaat agtaaccgga agatcgatca gggtagtgag aagcttttta
    10201 cccctgaact gaaacttcgt cagtgcccag gctgcaaaaa caccaaaaac agtgttaaaa
    10261 acaactgcaa agagtgttgc cttcactgta agaagaagtg ctttgatggt gtactcatct
    10321 gtcactgcag ctgcatagac cttccatccg ctccgcaatg cttctgtgat cacagtgatc
    10381 agaggaagaa ggagcatgac tgccagaaac agaacactga tcccgacaag cagccatttt
    10441 gtaattttct ccgaagtctt ttcattgttg tccatcaggc atttcctcct cttaaaattc
    10501 ttgcatttct ctgctgtatc atactgttaa ggaacagaat aaaaaatgaa actgccaaca
    10561 tcacaagtgc gattgccgtt gcacttgaat aatcaaattc ctgaagcttt gacataataa
    10621 ccagcggtgt gatttctgta taatagggtt tatttcctgc gataaataca acacttccat
    10681 attcacccag acatcttccg aacgcaagtc cggtccctgc aaagatcgcg ggcttcagtt
    10741 ccggaaaaat gaccttccag aagatagttg ttttctttgc tcccaacact cctgctgcct
    10801 cgctgtaaga attatccatc ttttccagaa ccggctgtac acttcgcaca acgaacggta
    10861 ttcctacaaa tatcatagcc actgtaatac ctattcttgt gtatgcgatc ttgataccga
    10921 atcctgcaaa aaagctgccg acaattcccg aatctgaggt cagggatgtc agtgcaatac
    10981 ctgctaccgc tgtgggaaga gcaaagggaa gttcgatcat cccatccata agtctcttgc
    11041 ccggaaaatc atatttcaca agcacccacg caagaacagt tcccataatt ccatttatta
    11101 ctgctgctgc aaaagcacat acaaaactgg tataaaagga tgccagcact ctggcccttg
    11161 tgatggtttc gataatatct ttaaaactca gcttcgctgt gtagaccacc aggcttgcca
    11221 gggggatcag aactaccaga ctcaatatgg aaatggtaat tcccatggag agcccaaacc
    11281 ctggaatcac cggtttattt ctttttttca taatcaatta ccacctctcc tgtctcatat
    11341 attctgtctg tgcttatgct cttgcttcat cttgtcttcc tttatctctc ataaatctga
    11401 tcgaaaattc cgccatctgt gaaatgtttc tcctgcactt tatcccatcc gccataatca
    11461 ctgatatttg ccagatttat attcagatca aacgtatcac tgtgcttctt caggattttc
    11521 tcattggtgg ggcggaaata attctctgct gcgatctcct gtgcttcgtc ggaatacaga
    11581 taattcaaat actcagttgc cacatctctt gtatctctgt aatccaccac ttcatctacc
    11641 accgccacag aaggctgtgc cagaatactt acgcttggag taacaatctc atactcatcc
    11701 ggataatccc gcatggatag ataagcttca ttttcccacg caaccagcac atctccttgt
    11761 ccgttctcca cgaaagaggt cgttgcgcct cttgcgcctg agtcaagaac caccacattc
    11821 cggtaaagtt tcttgataaa ttccttcatc tgcgcttcat cgccaccata ctttttatct
    11881 gcgtaagccc acgctgccat gtagttccat ctggcaccgc cggaggtttt cggatttggt
    11941 gttactactc ccactccttt tttcgtcaga tcgtcccagt ctttgatatc cctgggattt
    12001 cctttcttca ccagaaatac gatagtggat gtataaggag aactgtcatt gtcaaattta
    12061 tctttccatc ctgccttgat cagccctgcg ttttcaatag actcaatatc atattcaagt
    12121 gccagggtta ccacatctgc atccagacca ttggctacct ccagtgcctg tttccctgaa
    12181 ccgccatggg actgtatcac ttccacatct tccccggtct tctccttcca gtggtcttca
    12241 aatattttat tatactgttc aaacatctct ctggtaggat cataggaaac attggtgaca
    12301 gacaccgttt ttccaaaagc ctgtaccggc atcagtgcca gtacaactgc aagaccaaag
    12361 gcaaataatt ttctgatcat gtttcatctc ctttaaggta ccagtagttt tttgcattct
    12421 ctacttttca tagttattcg atatgtttta tatgatatta caagaaatga cagaatttgt
    12481 caatagtgta ttaaaataag tacaatttat gttgtgtaga taagaacaca aaaaaagcag
    12541 catcctgaaa tacagaatgc tgcagtcaaa attacatatt ttttattcgg cagaagctgc
    12601 tgccttttct ttctccggga aaagctttcc gaaaataaat cttacgaatg gtccggcata
    12661 aaagatctgc cagaagaatg ccatcggaaa gttcattgct gttgtctgga gccatgtggg
    12721 aatgatctga cttgccggtg catgtttgat cagcacagtt gccgcaaagc tcatacatgg
    12781 acacataaat gcaacggata ctgctgagat tgcaagtaca aggtggaacg gattatctct
    12841 tctcatatcc acaataccaa atgcaatctt ctttgcaaga ccaccgatga taaagaaatc
    12901 aagaataaat gcaatcggtc ccatgaatgt taattcatga aaagctaaca gaaatgtctc
    12961 atttgtcatt gtccctgtat tcagtacaat gttgtagcag atcatggcat aaaccattac
    13021 aaacaccatg ataatcgtaa aaataacttc ctgaaacttg tttttaggca taaaaatcct
    13081 ccttagatag tatgaataac atcaattaga gatttgtgtt gttcataacc atccaggagg
    13141 atgtaccgtt tccaataata ccaaatatct gtttcttaaa tttaccgttg gttattatac
    13201 ggactgtttt aaaaaaagtc aaggattttt tcagtacctg cagtgtgaat caggaaacaa
    13261 aggttactgt tcacacacca ctgtcccgcg aggtgtnnnn nnnnnnnnnn nnnnnnnnnn
    13321 nnnnnnnnnn nnnnnnnata gtggtgtgtg aacagtaaca acaaagttta tttctacaaa
    13381 tacgggatcc ccggtatctc cggataactg cccattccga tcagaagctc cagacctgtc
    13441 tgtctggcat ttaataccgc tgtcttagca gcactggcat ctccggaaac tgccaggatc
    13501 acttcattgg aatggctggt tcccttattc ggcgtcatat atttcgcaat ggaaagaggc
    13561 gctgatttca tcgcagtatc tgccatcaca agccctnnnn nnnnnnnnnn nnnnnnnnnn
    13621 nnncggtact ccgaatgctt tattcagagc ctgtcctgca ctggctgaat aggcaaattc
    13681 cagatgtccg ctctcgctga tatagagttc acctgcatat ttattcgtaa gttccaaagc
    13741 catagatatg gcatggcgaa catccgagac atcagttccc ccaagaacaa tatagtttcc
    13801 atgaccaccc catcccttgg tatccctcgg caattctatg gaaagaacct ctgtgttggt
    13861 tgctttcacc gcatcatcga tagcagtgat ctgccctgca gcacctgtac gggagctgaa
    13921 caatcccaga cagcgatact tcattcctac gttcatagtc tccagcaaag tatcatcaat
    13981 ccctgaaatc acaagcccga tcgtatccag aactgcggtt cctacaaatt catttcttgt
    14041 acagtttgta cttatcttgt gtacatctat catttgaaat cctctcccgt tctttttcct
    14101 gtatttactc tgttaatggg tatcttccgt ataccgctct ctgagtcagg caacaacttt
    14161 ctgcgcgttt tttcttataa caattccatg aaataatgat aacatgaaac cattttaccg
    14221 taaagttaga tcatgcacat tccttggatt tctcggtttt tctgcgattt ttcccatgcg
    14281 gagattgtga atatctgcct gacttatagc aaaagagtcc ttctgtttcc cactacatta
    14341 ataataacaa gtttctgata gattgcccga tatgggctta gaatttatag atgcgtgcaa
    14401 attttccgct aaaaataact accggtttta agaaatattt cagaaccttc acatattttg
    14461 ttcaaactct tcaagagaag acactttaag cgaaagctgg aaccacaggt taagtttttc
    14521 aatatctgtt tcggacatga ttttctcttt taactcagac ggaactgaaa atttggattc
    14581 aagcgcagta agaagaaatt cctgttttcc ttctgtattt ccttcccgtt tttcattcct
    14641 catcatttcc tctaacagca tatatctttc ctccatccca cgattctgct tgatcttatc
    14701 aatactgtcc tgcagatgtc tgacaaatgg atctgtcgtt gaaatccctt ctgttcgccc
    14761 ggtatttttt acataatcca gaaactgcag taattcttct ggaatatcct ctctgttcct
    14821 tccatgtgca ttgagataaa tagttttcac accatcactt acagattttc ccgtttcttc
    14881 acagaccata cctgttgaat aacgatacaa tccatcaccg aatggatcaa aatcacagat
    14941 aaaaataaca taagtatccg gaagattctc ataggaatca cctgcaagta aggcgtccat
    15001 gtctatctgg tcatgataat aacggcttct tttcggaaga aatttctgca aagtaacctg
    15061 catctccaca ttgaaacgtg ttctgtcagc atctgcagca taaacatcca gacgaacccc
    15121 atgatattct gaatgatatg ccatggtttt ctctgtctga atgtgtactt ccgaaatcgg
    15181 aattcccaat gccagctcca gcactcttcg gcagatttcc ggatcagaca tcactgctgc
    15241 aaacataaac gcatcccgta ttgtcagatc tttgaatttt ctggtttcca ttcttctgtc
    15301 ctttccgaag cagaagaact ctttggactt agtataatgc aaaaaaatga attctacaac
    15361 aaaaagtttt cgac
//
