LOCUS       c00036_gnlPro..        12323 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPBLLOKO_36.
ACCESSION   c00036_gnlPro..
VERSION     c00036_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:35:51
            Original ID  :: gnl|Prokka|EPBLLOKO_36
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12323
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12323
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2276:5238]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2277..5238
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..12323
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12323
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(358..1773)
                     /locus_tag="ctg36_1"
                     /transl_table=11
                     /translation="MWEAINSFLTTVDNLVWGVPLMVLIMAGGILLTARLGLLQMRRLP
                     LALKWMFKNEEEGDGEISSFAALCTALSATIGTGNIVGVATAVCAGGPGALFWMILAAF
                     FGMATKFSEGLLAVKYRVVAEDGHSLGGPFYYIEKGMGTKWKWLAKIFAFFGVCVGLFG
                     IGTFSQVNGISSAVQNFFDPNKSNCVNIPFLGEYSWAVVISSLILAACVAAILIGGLKR
                     IATVSQIIVPFMAVIYLIFSVALILLNITEIPAAIVTVVKGAFNPSAVTGGVVGTMIVS
                     MQKGVARGIFSNEAGLGSAPIAAAAAQTNEPVRQGLVSMTGTFIDTIVICTMTGLSIVL
                     TGAWQVEGLEGVQVTTYAFQHGLPIPGQISAFVLMICLVFFAFTTILGWDYYSERCLEY
                     LTNGHKKTILTYRWLYILAVFIGPYMTVSAVWTIADIFNGLMAIPNMIALFALSGVIVK
                     ETKAFFAAEKHKM"
     CDS             complement(2277..3956)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_2"
                     /sec_met_domain="HGD-D (E-value: 9.4e-18, bitscore: 53.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 6.5e-66, bitscore:
                     211.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTYYVCKYTPIELLESLGGECENFNHMPEGFDLADQVSHPNIC
                     GFGKTLLEGVMEGKIKELVLVSCCDTIRSVYDILLESGKLDFLYILDVLHCDSACSRER
                     MAVQLKGLAKAYAQYKGTEFDAGKFRAAFHAQEKITKSHIAVLGARMGQELFEMTSKAM
                     PLPVENDTCVHNRSVGNILPPEGASFDELMDWYAGEILGQIPCMRMMDPTGRKKLYNDP
                     SVAGIIYHTVKFCDFYSFEYAEIKNHTDVPLLKIESDYTIQSSGQLLTRLEAFAESIQP
                     ETLEQTIDGDTKGERKMGKGYFAGIDSGSTSTDVVILNKDHEIVTSIILPTGAGAAIGA
                     DRALAEALKEAGLQREDIDALVTTGYGRTAIKNGDKSITEITCHARGAHFLNPEVRTVI
                     DIGGQDSKVIRLDENGAVANFVMNDKCAAGTGRFLEMMARTMEMNLDQMSECGLEFKED
                     ITISSMCTVFAESEVVSLIAQNKATDDIVHGLNKAVAVKTAALTRRVGGEEKYMMTGGV
                     SKNKGLVKTLEEKLGTKLVISDKAQLCGALGAALFAADMADV"
     CDS             complement(3949..5238)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_3"
                     /sec_met_domain="HGD-D (E-value: 1.7e-56, bitscore: 181.2,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKRQTMEIIETFGHYVENLTDKKPQSARRLLKTGWEAQNLKFRY
                     MQDKRLMPADRHLANLMMDTMLWPLQKPEDSVIVSIFTPCEMMQEVGLHPYNVEGFSCY
                     LSASKAERAFLQQAENQGIAETLCSYHKTFLGAAQKGLLPKPKCIVYTNLTCDANLLTF
                     RTLADFYQVPVFAIDVPWNQTTENVQYVADQLKDLKIFLEKNTGKTISEDRLKERLACS
                     KRTLENYKKYQQMRADRYVPSDLVTPLYAGMTNNILLGTAEEEKYTQMLLEDIKKAPAA
                     KGKHIYWMHTIPFWSDAVRQELCFSEKAQIVGCELAETCEPDFDPENPFEAMAERMVYH
                     SLNGSALRRIEAGIRHAKQAGADGAVWFGHWGCKHTLGAAQLAKKKFEEAGLPLLILDG
                     DGCDRSHGGEGQTSTRLGAFLEMLGGAENE"
     CDS             5465..7279
                     /locus_tag="ctg36_4"
                     /transl_table=11
                     /translation="MRSLAVYLKSYKKESILAPFFKFLEVVFDLIVPIVIAQIIDVGIS
                     NHDNKYIVQRFFILILMAALGLASSITAQFFAAKASVGFATKLRQAVYDHVQHLSFTEL
                     DTLGTDTLITRLTDDINQVQNGLNMGLRLLLRSPFIVLGSMVMAFTIDFKCALVFAVAI
                     PFLFLVVFVIMFLSIPLFKKVQGKLDTVTGLTRENLTGVRVIRAFCREKEAVAEFDTRN
                     QELTKLNLFVGKLSALLNPVTYVLINIATVILIQKAGVEVNLGGMQQGQVVALYNYMAQ
                     MIVELIKLASLIITLNKSAACAGRVADILKVKSTMDYPSSSTYSAQISKDLATATADAS
                     LSENAIVFNDVTFEYSKAGAPSLSHISFSVKRGQTVGIIGGTGSGKTTLVNLISRFYDA
                     SKGTVLLDGQNIENYTRSDLRSRIGVVPQKAALFKGSIRDNLKWGREDASDEDLWQALT
                     TAQGKEVVEGKPGQLDFMLEQNGKNLSGGQKQRLTIARALVKKPEILILDDSASALDFA
                     TDAALRKSLNRLDWKVTTFLVSQRSSSIQQADLILVLDNGTLAGKGTHAELLRTCDTYR
                     EIYFSQFPEERARYSSVSAGNIMKEVTV"
     CDS             7276..9042
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     286.7; E-value: 2.2e-87)"
                     /gene_kind="resistance"
                     /locus_tag="ctg36_5"
                     /transl_table=11
                     /translation="MSRSTIKDPAKSKSSETFFKVLRFIGRYRFLLIFSIILAAVSVIL
                     QLYVPILFGNAIDQVIAQHQVNFEMMWYYLSRILVMVILSSAATWLMNVINNRMTYQTV
                     KDIRAKAIRHIQVLPLSYLDGHSTGDIISRIIADTDILSDGMLLGFTQLFSGIVTIIGT
                     LIFMFSKNFWITLMVIVLTPVSFLVAKFISSHTFQMFRKQSDARGRQTALIEEMIGNQK
                     VVQAFGYEEKSSERFAKVNEELQECSLKAVFYSSLTNPSTRFVNNVIYACVALVGAFII
                     PGGRLTVGGLSVLLSYANQYMKPFNDISSVVTELQNALACAGRIFDLLEEEPEVAEASE
                     TLKDVKGEVDIKNVCFHYDESKKLIEDFNLHVKPGMRVAIVGPTGCGKSTFINLLMRFY
                     DVNSGSISVDGKPIRDITRHSLRSSYGMVLQETWIKNGTVRDNISIGKPEATDTEIIEA
                     AKLTHSWEFIRRLPKGLDTMLNEDSLSQGQKQLLCITRVMLCLPPMLILDEATSSIDTR
                     TELQIQEAFERMMEGRTSFIVAHRLSTIRNADLILVMKDGSIIEQGTHDELIAKGGFYH
                     TLYNSQFAKVSE"
     CDS             complement(9130..10917)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M24"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_6"
                     /sec_met_domain="Peptidase_M24 (E-value: 3.7e-43, bitscore:
                     136.5, seeds: 437, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKERIAALRARMKETGIDAYLIPTDDFHGSEYVGEYFKCRKYI
                     TGFTGSAGTAVIMQDMAGLWTDGRYFIQAADQLEGTGITLFKMGEPEVPTVHEFLKKNL
                     TQGRCLGFDGRTVSAKEAAELEKMLDENGVSLSVDHDLAGDIWENRPVLSCEPVTELDI
                     KWAGESRADKCARIRKAMEKKGADLFVLTSLDDIAWLLNIRGGDIHCCPVVLSYLVMTK
                     TEIRLFANEKAFQTDVLEALEKDGVTLFPYDSIYEYVKTFKKDKKVLLCKKKVNSRLVS
                     NIPADTRILDEENLTLLPKATKNPVEVENERIAHIRDGVAVTKFIYWLKKNVGRIPITE
                     LSAAEKLYEFRSEQEDFIDNSFDPIIAYGKHAAIVHYFATPETDIPLEPSGFLLADTGG
                     HYKEGTTDITRTVVMGPTTEEEKKYFTAVLRGTLNLGAARFLHGCTGVNLDILARQPLW
                     EMGEDFKHGTGHGVGYLLNVHEGPNSFRWKIVPGGNAVLEEGMITSDEPGYYREDGFGI
                     RHENLMVCKKAEKTEYGQFMCFEFLTMVPFDLDGVVPELMSVRERNLLNDYHAQVYEKI
                     SPYLNEEEKEWLKDATRAI"
     CDS             complement(10914..11762)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP_bind_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_7"
                     /sec_met_domain="ATP_bind_3 (E-value: 6e-08, bitscore:
                     21.6, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLEHLKEYLKGLGSVAVAFSSGVDSTFLLKVAHDVLGDKAIA
                     ITAQSCSFPKRELNEAKAFCEKEGIQHVICQSEELEIEGFSKNPPNRCYLCKKELFEKI
                     GDIAKKNGIEYIAEGSNMDDNGDYRPGLIAVKELGVKSPLREAKLTKAEIREYSKELGL
                     PTWDKQSFACLSSRFVYGETISEEKLGMVEKAEQLLLDYGFHQVRVRIHGSLARIEIMP
                     EEFPKLLEKNVREDIAKKFKEYGFTYVTMDILGYRMGSMNETLGENDKTTADSSLKGKN
                     E"
ORIGIN
        1 aaacgatata gtccagagat ggattaaaag tcactgtgta aatcatctct tctttccctc
       61 ccgttttata ttggtatcct ttcggagtct ttatttcact ttcaccaaaa gattccaaaa
      121 gtacatattg tcatgtcttt tctgcatgtt catgactgtt ttttgtttat gatcttagta
      181 tactgtcata ttcatccaaa gtcaatcaaa ctaattcata aaaataatga ctgattttgg
      241 tttactttgc acaaaaagtc ataatcagtc aaatgcaagc agaaaaaatc ctctgatcag
      301 gattgctata aattccataa tcagaggatt tactgttatt ttattacttt tgattcctta
      361 cattttatgc ttttctgctg caaagaacgc ttttgtttct tttacgatca ctccacttaa
      421 tgcgaacaat gcgatcatat tcggaatcgc catcagtccg ttgaagatat ctgcgatcgt
      481 ccatacagca cttactgtca tgtacggtcc gataaatact gccagaatgt aaagccagcg
      541 atatgtaagg attgttttct tatgtccgtt tgtcagatat tccagacatc tttcactgta
      601 ataatcccat ccaagaattg tagtaaatgc aaagaatacc agacagatca ttaatacaaa
      661 tgcagaaatc tgtccaggga tcggaagtcc atgctggaat gcataggttg ttacctgaac
      721 accttccaga ccttctacct gccatgcacc tgtcagcacg atggaaaggc ctgtcattgt
      781 acagatcacg attgtatcaa taaatgtacc agtcatgctt acaagtccct gacgtactgg
      841 ttcatttgtc tgagctgctg ccgctgcgat aggtgcgcta ccaagacctg cttcatttga
      901 aaagatacca cgagccacac ctttctgcat ggatacgatc attgttccta ccacaccgcc
      961 tgtcactgct gacggattaa aggctccctt cacaactgtt acgatagctg ccgggatctc
     1021 tgtaatgttt aaaagaatca gcgctacact gaagatcaga tagatcaccg ccataaacgg
     1081 tacaataatc tggctgactg ttgcaattcg tttcagacca ccgatgagga ttgctgcaac
     1141 acaggctgca agaatcagag aagaaattac aactgcccag gaatactctc caaggaacgg
     1201 aatatttacg cagtttgatt tgttcggatc aaagaagttc tgaactgcac tggaaatacc
     1261 atttacctgg ctgaatgtac cgattccgaa aagacctaca catacaccaa agaatgcaaa
     1321 gatctttgca agccatttcc attttgttcc catacctttc tcaatataat agaaaggacc
     1381 gccaaggctg tgaccgtctt ctgctaccac acggtatttc actgcaagaa gaccttcgga
     1441 aaattttgtt gccattccga agaatgctgc aagaatcatc cagaataaag ctccgggacc
     1501 tccggcacag acagcagttg caacaccgac gatattaccg gttccgattg tggcgctcag
     1561 tgctgtacat aaagctgcaa agctggaaat ctcaccatcg ccttcttctt cgttcttaaa
     1621 catccatttc aatgcaagag ggagtcttcg catctgaaga agtccaagtc tggcagttaa
     1681 caggatacca cctgccatga tcaggaccat aaggggcacg ccccagacca gattgtctac
     1741 tgttgtcaaa aaagaattga tcgcttccca cataataata aatctccttt ttcttttaaa
     1801 aagtgtaata tattgtacag ctgggaaaca aagtaataac agaccgtttc aaaaatcaga
     1861 agttcagaaa atactgttca tatagttcat atgaatcagc ggggatgata aagcatcctc
     1921 tgtccttttg cctgagagat tcaagacacg aatcagataa ccatttgtgg gcagctattg
     1981 ataattcgtg ttatttgcac cttcggcccc cgatctaacg ggtgtctcca gagaaacgat
     2041 ccatttgcag ttcttccctg catccaggga acctgagagt tttactcctt cggcgggtat
     2101 agccttttgt gtggcttcct ctttcctgca aacttcacct cgttaatttg ctgttactgt
     2161 ggtatactat agctcttaaa tttgaactcg tcaatagaaa attaaacttt tataaaaaaa
     2221 gtataaaaat tccagagatt tccaccttgt aaaatccctg gatatttaaa taatttttat
     2281 acatcagcca tatcagctgc aaacagcgcc gcgccaagtg caccgcaaag ctgagccttg
     2341 tcactgatca ccagctttgt tccaagcttc tcttccagtg tctttaccag gcccttattc
     2401 ttagaaacac caccggtcat catatatttc tcctcaccgc ccacacgtct ggtaagggcg
     2461 gcagtcttta cggcaaccgc cttattcagg ccatggacaa tatcatctgt tgccttattc
     2521 tgggcgatca gggatacaac ttctgattct gcaaatactg tacacatact ggaaattgta
     2581 atatcttctt tgaattccag cccacattcg ctcatctgat ccagattcat ttccatggta
     2641 cgtgccatca tttccagaaa tcgtccggtt cctgccgcac atttgtcatt cataacaaag
     2701 tttgcaactg caccgttctc atccagtcgg atcaccttgc tgtcctgtcc gccaatatca
     2761 ataacagtac ggacttccgg attcaggaaa tgcgcacctc ttgcatgaca ggtgatctct
     2821 gtgatactct tatcaccatt tttaatagct gtacgtccgt atccagtagt aaccagcgca
     2881 tcaatatctt ctctctgcaa tccggcctcc ttcaatgcct ctgcaagggc acggtctgct
     2941 ccgatagcag ctcctgctcc tgtaggcagg ataatactgg tcacaatctc atgatcttta
     3001 tttaaaatca ccacatctgt actggtggaa ccactgtcaa tccctgcgaa ataacctttt
     3061 cccatttttc tctctccttt tgtgtctcca tctatggtct gctccagtgt ttcaggctga
     3121 atgctctctg caaaagcttc cagtctggta agaagctgac cgctgctctg aatagtataa
     3181 tctgattcga tttttaaaag aggtacatct gtatgattct tgatctcagc atattcgaag
     3241 ctgtaaaaat cacaaaactt cactgtatga taaataatcc ccgcaacaga cggatcatta
     3301 taaagcttct tacgacctgt cgggtccatc atacgcatac atggaatctg ccccagaatc
     3361 tcacctgcat accagtccat cagctcatca aaagaagcac cctccggtgg aagtatattt
     3421 cccacagaac ggttatgcac gcaggtatca ttctctacag gaagaggcat agccttgctg
     3481 gtcatttcaa ataattcctg ccccattctg gcgccaagca ctgcaatatg ggactttgtg
     3541 attttctcct gtgcatggaa agcagcccgg aattttccgg catcaaactc tgtgcctttg
     3601 tactgtgcat aagccttcgc cagccctttt aactgtacag ccatacgctc tctgctacag
     3661 gcactgtcac agtgaagcac atccaaaata tagagaaaat ccagcttgcc gctttcaagc
     3721 agaatgtcat agacactccg gatagtatca cagcagctca ccaggacaag ttccttgatt
     3781 ttcccctcca tgactccttc cagaagtgtt tttccaaaac cgcagatatt gggatgtgaa
     3841 acctgatcgg ccaggtcaaa tccctccggc atatgattaa agttctcaca ttccccgcca
     3901 agagattcca gaagttcaat tggggtatat ttacagacat agtaagtttt attcattctc
     3961 agcacctccc agcatttcca gaaaagctcc cagcctggtg gaagtctgtc cttctcctcc
     4021 atggcttcga tcacacccgt caccgtccag gatcaaaagg ggcagaccgg cttcctcgaa
     4081 cttcttcttt gcaagctgtg ccgcaccaag cgtatgttta catccccaat gtccaaacca
     4141 cacagcaccg tctgctcctg cctgtttcgc atggcggata ccggcttcaa tccttctaag
     4201 ggcacttccg ttcagtgaat gatataccat tctttctgcc attgcttcaa aggggttctc
     4261 aggatcaaaa tccggctcac aggtttctgc aagttcacat cctacgatct gggctttctc
     4321 actgaagcaa agctcctggc gcactgcatc cgaccagaat ggaatggtat gcatccaata
     4381 aatgtgcttc cctttcgctg ccggtgcttt cttaatatct tcaagaagca tctgtgtata
     4441 cttctcttct tctgctgttc ccagaaggat attgtttgtc attcctgcat acaagggtgt
     4501 gaccagatca gagggcacat atctgtctgc acgcatctgc tgatattttt tgtaattctc
     4561 cagagtccgc ttactgcagg caagacgttc ctttaatctg tcctcagaga ttgtttttcc
     4621 tgtatttttt tccagaaata tttttaaatc ctttaactga tctgccacat actgtacatt
     4681 ctctgtggtc tgattccatg gtacatcaat ggcaaataca ggtacctggt aaaaatctgc
     4741 cagggtacgg aaggtgagca ggttagcatc gcaggtcagg ttggtataaa caatacattt
     4801 aggctttggc agaagtcctt tctgcgctgc accaagaaat gtcttgtgat aactgcacag
     4861 tgtctctgca attccctgat tctctgcctg ctgcaaaaat gccctctctg ctttgcttgc
     4921 agaaagatag caggaaaatc cttctacatt atagggatgt aatcccacct cctgcatcat
     4981 ttcgcagggt gtaaaaatac ttacaataac agaatcttcc ggtttctgaa ggggccacag
     5041 catggtatcc atcatcaggt ttgcaagatg cctgtctgca ggcatcagtc tcttgtcctg
     5101 catgtaacgg aacttcagat tctgcgcctc ccagccggtt tttaacagcc ggcgggctga
     5161 ctgaggcttt ttatccgtca gattttccac ataatgacca aatgtctcaa taatctccat
     5221 agtctgtctc ttcctcatta tggtaataat aatttatcaa ttgtcagtgc acaaatagtg
     5281 ccacgcaata ttttagtaat atcttttttt gaagtcaagc tgaattttct ccaaagttca
     5341 tctgtttttg cacattcttc ttgacaaaaa agtctcaaat gatacacttt tgaatgtatt
     5401 atttttcaaa aaaaggaaga aataatatag gaaagatttt ttacgaaagg aaggaatttt
     5461 taaaatgcgt tcattggcag tttatttaaa aagctacaaa aaagaaagca tcctggcgcc
     5521 attttttaaa tttctggagg ttgtatttga cctgatcgtg cctatcgtca ttgcacagat
     5581 cattgatgta ggtatttcaa accatgacaa caaatacatt gtccagagat tttttattct
     5641 tattttaatg gcagctcttg gtcttgccag cagcattaca gctcagttct ttgcagccaa
     5701 agccagcgtg ggctttgcca ctaaattaag acaggccgtt tatgaccatg tacagcatct
     5761 gtcttttaca gagctggata ccctgggaac agacaccctg atcacaagac ttaccgacga
     5821 tatcaatcag gtccagaacg gactgaacat ggggcttcgt cttcttcttc gaagtccgtt
     5881 tatcgtactt gggtccatgg tcatggcatt taccattgac tttaaatgtg ccctggtttt
     5941 tgctgttgcg atcccgtttc tgtttctggt tgtctttgtc attatgtttc tcagtattcc
     6001 tctgtttaaa aaagtacagg gaaaactgga cacagtaacc ggactgacca gagaaaacct
     6061 tacaggcgtc cgcgttatcc gtgcattctg ccgcgaaaaa gaggcagttg cagaatttga
     6121 tacccgcaat caggagctga caaagttaaa tctctttgta ggaaagcttt ccgctttgtt
     6181 aaatccggtc acttacgtac tgatcaatat tgctactgtc atcctgatcc agaaagcagg
     6241 agtagaagta aatcttggcg gtatgcagca gggacaggtt gttgcccttt ataactatat
     6301 ggctcagatg atcgtggaac tgatcaagct tgcctccctg atcatcaccc tgaacaaatc
     6361 tgcagcctgc gcaggacgtg tggcagatat cctgaaagtg aaatctacta tggattaccc
     6421 ctcttcctcc acatattctg ctcagatatc gaaggacctt gcaacagcaa ctgctgatgc
     6481 atcactttct gaaaatgcca tcgtattcaa tgacgtaacc tttgagtaca gcaaagccgg
     6541 tgcccccagt ctttcccata tcagtttttc tgtaaaaagg ggacagaccg taggtattat
     6601 cggtggtaca ggaagcggaa aaaccactct ggtaaatctg atctccagat tctatgatgc
     6661 cagcaaagga actgttctgc tggatggtca gaatattgaa aattacacca gaagtgatct
     6721 ccgctccaga atcggcgttg ttccacagaa ggcagctctt ttcaaaggct ctatccgaga
     6781 caatctgaaa tggggccggg aagatgcctc tgacgaggat ctgtggcagg cacttaccac
     6841 agcacaggga aaagaggtag tagagggtaa accgggacag cttgatttta tgctggaaca
     6901 gaacggtaaa aacctttccg gcggccagaa acaaagactt accattgccc gtgccctggt
     6961 aaaaaaacct gaaatcctga ttctggatga cagtgccagt gccctggact ttgccactga
     7021 tgcagcactg cgtaagtctc tcaacagact tgactggaaa gtaactacat ttctggtatc
     7081 ccagcgttcc tccagcattc agcaggcaga cctgatcctt gtccttgata acggtactct
     7141 ggcaggtaag ggtactcatg ctgaactgct gcgtacctgt gatacttacc gggaaatcta
     7201 cttctctcag tttccggaag aaagagccag atactcctct gtatctgcag gtaatataat
     7261 gaaggaggtg actgtatgag cagatcaaca ataaaagatc ctgctaaaag caaaagcagc
     7321 gaaacttttt ttaaagtact gcgtttcatc ggaagatacc gttttctgct gatcttcagt
     7381 atcatactgg cagcagtttc cgttatcctt cagctgtatg tcccaatcct gttcggaaat
     7441 gccattgatc aggtcattgc ccaacatcag gtaaacttcg aaatgatgtg gtattacctg
     7501 tcacgtatcc ttgtaatggt catcctctct tctgctgcca cgtggcttat gaatgtgatc
     7561 aataaccgca tgacctacca gacagtaaag gatatacgtg ccaaagccat ccgacacatt
     7621 caggtacttc ccctctctta ccttgacgga cacagtaccg gagatatcat cagccgtatt
     7681 atcgcagata cagatattct atccgatggt atgctgcttg gatttaccca gcttttttcc
     7741 ggaatcgtaa cgatcatcgg aacactgatc ttcatgttct ccaaaaactt ctggattaca
     7801 ttgatggtca ttgtcctgac ccccgtaagc tttttggtgg ccaaatttat ttcttcccat
     7861 accttccaga tgttccggaa gcaaagcgat gccagaggac gtcagactgc tctcatcgaa
     7921 gagatgattg gaaaccagaa ggttgttcag gcttttggat atgaggaaaa atcttctgaa
     7981 cgctttgcaa aggttaacga agaattacag gaatgcagtc tgaaggctgt tttttacagc
     8041 agcctgacaa acccttccac ccgttttgtc aataatgtta tttatgcctg tgttgcactg
     8101 gtgggtgcat tcattatccc tggaggcaga ctgacagtcg gaggactttc cgtacttctc
     8161 tcctatgcca accagtatat gaaaccattc aatgatatca gttccgttgt tacagaactt
     8221 cagaatgctc ttgcctgtgc aggcagaatc ttcgatctgc tggaggagga accggaagtt
     8281 gcagaggctt ctgagacact gaaagatgta aagggtgaag tagatattaa gaatgtgtgc
     8341 ttccattatg atgaatcaaa gaaactgatt gaggacttta atctccatgt aaaaccaggt
     8401 atgcgcgttg ccattgtagg acctaccgga tgcggtaagt caacctttat caaccttctg
     8461 atgagattct atgatgtaaa ttccggatct atttccgttg acggcaaacc gatcagagac
     8521 attacccgcc attctctcag aagcagctat ggtatggtgc ttcaggaaac atggatcaaa
     8581 aacggaactg tccgcgacaa tatctcgatt ggaaaaccgg aagctacaga tactgaaatc
     8641 atcgaagcag ccaagcttac ccacagttgg gaatttatcc ggaggcttcc taaaggactg
     8701 gacaccatgc tcaacgaaga cagcttaagc cagggacaga aacagctgct gtgtatcaca
     8761 cgagttatgc tctgtctgcc tccgatgctg atcctggatg aagccacttc cagtattgat
     8821 acacgaacag aattacaaat tcaggaagcg tttgaacgaa tgatggaggg aagaacaagc
     8881 tttatcgtag ctcacaggct ttcaaccatc cgaaatgcag atctgattct tgttatgaaa
     8941 gacggaagta tcattgagca gggtactcat gatgagctga ttgcaaaagg tggattttac
     9001 catactttat ataacagcca gtttgcaaaa gtttctgaat aaaacaagcc agataataaa
     9061 tcaaaaagga acagctgtcc atcacggctg ttcctctttt tgattttgta aaatgttttt
     9121 ttatttttat cagattgctc gggtagcatc tttcagccat tctttttctt cttcgttcaa
     9181 atacggagaa atcttctcat atacctgcgc atggtaatca ttgagaaggt tacgttcccg
     9241 gacactcatc agttccggca ccactccatc cagatcaaaa ggtaccatag tcagaaattc
     9301 aaagcacata aactgaccat actctgtttt ttcagctttt ttgcagacca tcagattttc
     9361 atgacggatt ccaaatccat cctctctgta atatcccggc tcatcagagg tgatcattcc
     9421 ctcctccagc actgcatttc cacccggaac aattttccat cggaagctat tgggtccttc
     9481 atggacattc agaagatatc ctactccatg accggttcca tgtttaaaat cctctcccat
     9541 ttcccacaac ggctgtctcg ccagaatatc cagatttaca ccggtacagc catgaagaaa
     9601 tctggcagct cccagattca gagttccccg caaaactgct gtgaagtact ttttctcttc
     9661 ctcagtagtc ggccccatga caacagtacg ggtaatatca gtagttccct ctttataatg
     9721 tcctcctgta tctgccagaa gaaagccgga tggttccaga ggaatatccg tttcgggtgt
     9781 tgcaaaataa tgtacaatag cagcatgctt tccataggca ataatcggat caaaactgtt
     9841 atctatgaaa tcctcctgtt ccgaacggaa ttcatacagc ttttctgctg cacttaattc
     9901 tgtgatcgga atccttccaa cattcttctt taaccagtat atgaactttg taactgcaac
     9961 tccgtctctg atatgcgcaa tgcgttcatt ttccacctca acaggattct tcgttgcctt
    10021 gggaagaagt gtaagatttt cttcatccag aatccgggtg tctgccggaa tattgctaac
    10081 cagacgactg ttgactttct ttttgcagag aagaactttt ttgtcctttt taaatgtttt
    10141 cacatactca tagatactgt catagggaaa aagggtcaca ccatcttttt ccagcgcttc
    10201 cagtacgtct gtctgaaagg ctttctcatt tgcaaaaagt ctgatctctg tttttgtcat
    10261 tacaagataa gaaagaacca ccggacaaca gtggatatct cccccacgta tatttaacag
    10321 ccaggcaata tcatccagag aagtcagtac aaataaatct gcacccttct tctccattgc
    10381 tttgcggatt cttgcgcatt tatcagctct ggattctcct gcccatttta tatccagctc
    10441 tgtaaccggt tcacaggaaa gtaccggacg gttttcccat atatcacctg ccagatcgtg
    10501 atcaacactg agagacacac cgttttcatc cagcattttc tccaattctg ctgcctcttt
    10561 tgcactgaca gtacgtccgt caaatcccag acaccttccc tgtgtcagat tttttttcag
    10621 aaattcatga actgtgggaa cttccggttc acccatttta aataaagtaa ttcctgttcc
    10681 ctccaactga tctgcagcct ggataaaata acgtccatcc gtccataatc ctgccatatc
    10741 ctgcatgatc accgcagtgc ctgcagaacc ggtaaatcct gtgatatatt ttctgcattt
    10801 gaaatattca cctacatatt ctgaaccatg aaaatcatct gtaggaatca gatatgcatc
    10861 aattcctgtc tctttcatgc gtgcacgaag tgctgctatt ctctctttta ctgtcattcg
    10921 tttttaccct taaggctgct atctgcagtc gttttatcat tttcgccaag tgtttcgttc
    10981 atacttccca tacgatatcc cagaatatcc atggtcacat aagtgaatcc atactcctta
    11041 aatttctttg caatatcctc tcggacattt ttttccagaa gtttcggaaa ttcctccggc
    11101 atgatctcaa ttcttgcaag tgaaccgtga atacggacac gtacctgatg gaatccatag
    11161 tcaagtaaaa gctgctctgc tttctcaacc attccaagct tttcctcact gatggtctct
    11221 ccatagacaa acctggagga cagacaggca aatgactgtt tgtcccaagt cggaagcccc
    11281 agttcctttg agtattctct gatctccgct ttcgtcagct tcgcctcacg tagcgggctc
    11341 ttaactccaa gttcttttac ggcgatcaga cctggtctgt aatcgccatt atcatccata
    11401 tttgatccct ctgcaatata ttcaatccca ttcttttttg caatatcgcc aatcttctca
    11461 aacagttctt ttttacataa ataacatctg ttcggaggat tctttgaaaa tccttcaatc
    11521 tccaattcct cagactggca gatcacatgc tgaatcccct ctttctcgca gaatgccttc
    11581 gcttcattca gctctctttt cgggaaagaa caggattgag ccgtaatcgc aatcgcctta
    11641 tcacccagca catcatgagc tacttttaat aagaatgtag aatccactcc acttgaaaaa
    11701 gcaactgcta cactgccaag tcccttcaga tattctttta aatgttccag tttattttcc
    11761 atatcagtct gcctcttgtc cgttttttat tgtacctgta gcactcctcg taaataatgt
    11821 atattgatct ggctcaacaa agcgtgaaag ttgaactttc tcaaatgtat tatttaacag
    11881 ggtgctatag cttcattata atataggcaa cgactgttca gcaacctatt tttcgcattg
    11941 cgaaatgtgt tactgaaaat agaacgaaca atattgattt atgtttcttg tatcttttct
    12001 aacgcttccc cgacttctat tacttcttta aatagtttct aaagtaacag cctctcttaa
    12061 cttctttatt tacagtttgt ctacttcttt ttctggagca gttctccgtt tgtttcttcc
    12121 ccattcatac atgacataat aattaaccac taccccatat tataaataac acccagagat
    12181 acttatttca gactgataat cagattttta ttgaatttat taatctatat gttatgacaa
    12241 catatctttc agacatgtac tccggtagtc actcggtgat attttatatc tttctttaaa
    12301 tactcggtta aatgttctct gac
//
