LOCUS       gnlProkkaFJJECKHO_18   14230 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FJJECKHO_18.
ACCESSION   gnlProkkaFJJECKHO_18
VERSION     gnlProkkaFJJECKHO_18
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 18:53:33
            Original ID  :: gnl|Prokka|FJJECKHO_18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 78178
            Orig. end    :: 92408
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14230
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11612]"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11612
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    1..14230
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14230
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="sactipeptide"
                     /region_number="2"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     CDS             complement(16..327)
                     /locus_tag="ctg18_79"
                     /transl_table=11
                     /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIAK
                     SLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPIG"
     CDS             complement(425..544)
                     /locus_tag="ctg18_80"
                     /transl_table=11
                     /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI"
     CDS             complement(528..1673)
                     /locus_tag="ctg18_81"
                     /transl_table=11
                     /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFSMDY
                     ARQAYEIYKENEAYNIRLLQCHSLFATNFLDLKQYEDAVSHFQKAYSMAEAEKQPQLMG
                     RTLYNIGLCKNSQSQYEDAITYFKRAIAVFEESNILPSLPQAYFLITQIHYKLGKMDKA
                     HEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYADLEDFT
                     IDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV"
     CDS             1903..2736
                     /locus_tag="ctg18_82"
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISDITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANPNDQSVSVIDTNTHTVVTTIALPYNPAGIEITPDKSAVFVLHPNNNV
                     ISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAIYVIGIDTLTVERSI"
     CDS             2769..3254
                     /locus_tag="ctg18_83"
                     /transl_table=11
                     /translation="MFAYVLNFGLVQKVDLSTGEVTGTIERELIVSSIETDSPERYAYV
                     LEQEFLFNYLTVIDLNTFTISNTQELEPDGQYRMFTSGTGVYLYDDFTGNLYSVSPNGA
                     GVIGNLPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAITI"
     CDS             3293..4669
                     /locus_tag="ctg18_84"
                     /transl_table=11
                     /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDIPKGFKVDSAEAS
                     AAVTWSTDNVSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGNGA
                     VSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVTGTLVLPPSPDPQ
                     SYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLVSVID
                     NKTLTIINTITVGGGPRKIEFDPKDEFAYVMAAGSIYVINTASQSVIDVIPIPGALDFA
                     LDPNGQYVYTANGSSWSVDKYDINTGQLVESIIDTFEFPSLIATPYAGNFAYVLNGELW
                     PKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTAR
                     QRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVGAGPSAIAM
                     "
     CDS             complement(4675..5376)
                     /locus_tag="ctg18_85"
                     /transl_table=11
                     /translation="MKKSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPALSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSFIYKR
                     FSYRSTASLDL"
     CDS             complement(5373..6653)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_86"
                     /sec_met_domain="Peptidase_M16 (E-value: 2.1e-14, bitscore:
                     46.4, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNDQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQTHRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYHAERKIIPACPPALSQKMMLGDEERMEDTWTGLQIGALPGQNDLWVIKLYWDIA
                     ARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHIIQDMDAQ
                     VFLSLIDAMASSNKAIIHVSQKEAIRQ"
     CDS             complement(6658..7842)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_87"
                     /sec_met_domain="Peptidase_M16_C (E-value: 1.3e-06,
                     bitscore: 21.2, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQAKENGLEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYF
                     YGAAAYLKEQIIDAFGCAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALLKT
                     FADLSFPSSLSFEAVEKARNELLLRIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRK
                     DRIKAIHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSERIPVNRH
                     VFETETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAV
                     YHVITRYDVMNNLLLVSICTDQLHEIDIPPRVLEAVSAFHTDERELEQAKQFLRNELLL
                     QFDSPEGLLAYMGILRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     CDS             complement(7808..9118)
                     /locus_tag="ctg18_88"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNAYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     LMFLLHAAIFACVCISAALMPAATLPLCAVHMLWAVIIDFPVFLQAPPQQSKMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAAFSGFFSFQMMNTGIFNQQVVYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFISGRPIS
                     VLTFLQCIELLLAGAFIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPLFLATLAG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     CDS             complement(9111..9830)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 127.7; E-value:
                     9.5e-39)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_89"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     CDS             complement(9827..9988)
                     /locus_tag="ctg18_90"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGI
                     RARKADSR"
     CDS             complement(10001..11347)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_91"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1081.0, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 1.2e-30,
                     bitscore: 98.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.6e-09, bitscore: 28.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.5e-23, bitscore: 75.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-11, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.7e-11, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLN
                     KTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRASR
                     HTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADMLFDN
                     GVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQKIIVG
                     ISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKV
                     RDLGAKAFSYNWVDDFGRGRDIAHPTKDAEQHRKFMEYEQNVIDEFKDLIPIIPYERKR
                     AANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRF
                     SEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI"
     CDS             complement(11481..11612)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_functions="biosynthetic-additional (sactipeptides)
                     predicted sactipeptide"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_92"
                     /sec_met_domain="Subtilosin_A (E-value: 2.1e-30, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       complement(11583..11612)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="ctg18_92_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       complement(11481..11582)
                     /prepeptide="core"
                     /locus_tag="ctg18_92_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="33.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[11582:11612](-)"
     CDS             11925..12353
                     /locus_tag="ctg18_93"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     CDS             12350..14020
                     /locus_tag="ctg18_94"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLEFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALRE
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     CDS             complement(13984..14157)
                     /locus_tag="ctg18_95"
                     /transl_table=11
                     /translation="MGALFLHLKPDEYLKKLYKTKKLVEKTSFSLQAKDKARRLCPFDR
                     DYIFSGADTPIS"
ORIGIN
        1 ctcaggatca tgagtctatc caattgggca aactcctcca atttcatggc ctgtctgctc
       61 cagtacctca ttaggagaga gcattcttgc tttaaagcca aatgtttgcc tggacttttt
      121 gttgtcgatc ttggcatcgc cggctgccac aatcagaatc acctgatctc cttcccctct
      181 gaaggacagg gacttggcga ttctagacag gcttacgccg attgtctcag ctgcctgttc
      241 aactgtcgca ctcgacgttt cgaactccgt cacatcattt tctcgattcc attgagtaaa
      301 gtgggttctc acacttttta gagacatgct gcatttccac tatttttaag attattgaaa
      361 aaatcataga atggattggg agactgggta aagaggggac aaaaaaaccg ccgatggacg
      421 gcggttaaat cattcctcgt tgtgcaactt caatttggtg tgtaggtgca tttgcaatag
      481 ttgttgccac gaacacagtg cttagagcca gacaagagag taatagttta gacttcaatt
      541 tcatacaaac tcactcctcc ttgaataagt tgccttactt gttccacctt caaaaaataa
      601 gcagaagctt tttgaaaatt tttacgttca tgataatatt ttgccacatc aatagtgaaa
      661 tcttcaagat cagcatacaa cattttactt tcgagaaaat caaaaaatcc ttgaattgct
      721 tcttcatccg ggcctgataa gtataaagat ttcaaaaatt caaactctga taaatatatt
      781 acatctccgg ccttttgtga ataagccatt cccttactat gatattcatg agctttatcc
      841 atttttccta atttataatg gatctgtgta attaaaaaat acgcttgagg taaggaagga
      901 agaatatttg attcttcaaa aacagctatt gctcttttga aatatgttat ggcatcctca
      961 tattggcttt ggctgttttt acaaagcccg atattgtaca aagttcttcc cattaattgg
     1021 ggctgctttt cagcttctgc catagaataa gctttttgaa aatgtgagac ggcatcctca
     1081 tactgtttta aatctaaaaa attggtggca aataaagaat gacactgcag caatcttata
     1141 ttataagctt cattttcttt gtatatttca tatgcttgcc gtgcatagtc cattgaaaaa
     1201 tacgtttgtt tcatatagta ataagattca gacatcttaa agaaaaactc agctttctct
     1261 atccgatcct taacgaatat cagcttgctt tcggcctttt tgaaaaattt aatagccgac
     1321 agatattccc gctgatccag ctcatacatg cctctgaaga aattaaaata gtactcaagc
     1381 agacctgtta aacgagcctg ttttttatca atctcaagca gcagatcaga cagtctcggc
     1441 tgttcctcaa tcctcatttt ttctaacggt tcaaggtact caagcatcag gttgtgccga
     1501 aactccatca gtgaatagta caaatgaagg tcttgatctt cttccatttg atccagctct
     1561 tgcttgattt ctcgtcgcaa atattctgca tcgggtatgc tgaatcggcg tatgtacata
     1621 taccattcgt taatcttttc tccgatggaa gaagaagata tgacacctgt cacgtttgca
     1681 aatccctccc ttcataattc tatatatgtc atattttatc atcaacattc ttgtgagaag
     1741 cgcaaaaaaa ccgcaatttt ttctttcgtt acaccgcatg tttggagata tattttcaaa
     1801 aagaagcttt taccctcagt aatttgtaca agcaaacacg ttactcttcc atattctgtt
     1861 atatctgcgt gagcagtgta tgtctgaaaa ggaagtgaag gaatgagaaa aaacaagctt
     1921 tcctttaaag aaaaagcagg agcagaacaa gaagagtgct tatgtttttg tgagggagaa
     1981 gcaagccgag aagccatgtt tcaagcgccg attgagttac ctgaaggatt tgtcgttgat
     2041 ccggctgaag ctgttgcaaa cgtgacgtgg aatgcagaca gcctttcttg tgtcagtgac
     2101 cgttgcttaa ttcaaacggg gccagagcct gatgaggtcg gtgttcaatt tgcagtgcgc
     2161 ctgcagggaa ccgttacgct actcgtcagt gtctcacctg tgcgaaatca atatggacaa
     2221 ggggacgggg ctgtttccgt cattcacaat gcagaaatcg atcaagtcgt ctattattcc
     2281 gatgaaccgg atgattgccc ggatatcagt gacatcacga ttgagaacct tgttgttgtt
     2341 ccgccgtttt acggcagtcc tttatcggtg acggggacga ttgtgcttgt accggagccg
     2401 gaacccgtct acgcgtttac agcgaatcca aatgatcaat cagtttctgt gattgataca
     2461 aacacccata ctgttgtgac aacgattgct cttccgtaca atccggcagg tattgaaatt
     2521 acgccagata aaagcgctgt gtttgtctta catcccaaca ataatgtgat ttctgtcatc
     2581 gattatgaca cattaacagt gacagcaact atattgctgg atcagccgcc tcgattgatt
     2641 agatttatcc ctaatcatga gtttgcttat gttttcaccg gtactgccat ttatgtgatt
     2701 ggaattgata cgttgactgt tgagaggtct atatagaagg ttttgatatt gcaattgacc
     2761 ccaatgggtt gttcgcctat gttcttaatt ttgggttagt gcaaaaagtg gacttatcca
     2821 ccggtgaagt cacaggaacg attgaacgag agcttatcgt atcatccata gaaacagatt
     2881 ctccggagcg gtatgcgtat gtcttagaac aagaattctt attcaattat ttgacggtta
     2941 ttgacttaaa tacgtttacg atcagcaata cccaagaact ggagcctgac ggccaatata
     3001 gaatgtttac gagcggaaca ggtgtgtatt tatatgacga ctttaccggc aatttatatt
     3061 ctgtcagtcc gaatggagca ggtgtaattg gaaatcttcc gcaatcagca acagactatg
     3121 cgtttacccc gaatggcgat tttctgtatg caactcgttt tatagagcag agcatcattg
     3181 tttacaacac agatgattat tctgaggaaa ctgtgatatc tcttggggtt tcaccgggtg
     3241 ccattacgat ttaaccgctg catgttgtgc atttctaaaa ggacgtgaat tcatgaaaaa
     3301 gaatgatctt tctgctttac aggaaaattg tttctgtttt tgtgatgagg aaattagccg
     3361 ggaagcgccg tttcaagtgc caatagatat ccctaagggc ttcaaggttg attcagccga
     3421 agcgtcagcg gctgttacat ggagtacaga caatgtgtcc tgtatcagtg agccttgctt
     3481 aatccagact gggccggaac cagaagatat cggtgttcga tatgctgtga gagtacaagg
     3541 gaccattacg cttcttgtca gtgtgtcgcc tgtgcgaaat caatatggac aaggcaatgg
     3601 ggcggtttct gtgattcata ccgaagagat tgatcaagtt gtttattatg cagcacagtc
     3661 tggccgctgt cctgatttca gtcaaataac agtggaagat ctgctcattg taccgccttt
     3721 ctacggcagt ccgcttacgg tgaccgggac acttgtttta ccgccatcac cagaccctca
     3781 atcgtatgtg tttactgcca atactggaga cagcacggtt tcggttattg atgcagattt
     3841 aaacactgtt gtaaaaacaa tccctttttc tgacgtgcca actaatctag gcgttacttt
     3901 cgataaagca ttcacgtatg tcctccatgg aaataccaac cttgtctcag tgattgataa
     3961 taaaacatta accatcataa ataccattac tgttggagga gggccgagaa agatcgaatt
     4021 tgatccaaaa gatgagttcg catacgtgat ggccgccgga tctatatatg tgattaacac
     4081 ggcctctcaa tcggtcattg atgtcattcc gatacccggc gctttagact ttgctcttga
     4141 tccgaatgga cagtatgtct ataccgctaa tggaagcagt tggtcggttg ataaatatga
     4201 tataaatact gggcagttgg tagaaagtat catagataca tttgaatttc ccagtttaat
     4261 tgcaactcct tacgctggaa attttgcgta cgtgttgaat ggtgagctgt ggccgaaagg
     4321 tgtaacggag attagtttgt ctccattaag caggggaggg gacttcagcc gtttatttga
     4381 aacgctgagg acgattgtat tttctctcga tagcactaga gcttattttc tagagccata
     4441 tagtgaaccg tttcttatta ataacttata tgtagttaat acggccagac agaggatcat
     4501 tgcaaacgtg tctctccccg gcgcttttga cctcgccgta acgccggaca aacagtatat
     4561 ttatgcggca cagcccaacg acaatgctgt gaccgtgtac cgcacaagtg attatacagc
     4621 cgtgacggtg attccggttg gcgcgggtcc gtctgcgatt gcgatgtagc tattttatag
     4681 atcaagagaa gcggtgctgc gataagagaa tcgtttataa ataaatgatc cgatttgctg
     4741 aatggcagcc aggataatca gaaacagcag ttcacttata gagaaactga gcatccacca
     4801 aatcccggct gctgccagcg ctcccgcaaa cacttttctg aacaggctgc cgtgccggaa
     4861 aagctgccgc aaataagttc gcatgcaaaa caataaatac agaatcagta gcatcgcaag
     4921 tcccattgaa agggcagggg gcgtgtgaag gcggaaaggg acggctttaa cgatttcgaa
     4981 catgcagccg aatatgatga cttggcacaa cacggcagcc atcacgtatg tttggcggac
     5041 gtttttatag ctgtcacgca gcgatttgac gtcttctgca tatcggctgc acaagttgtg
     5101 ttgctgaaag tcacagcagc tttgatgaga ctgtgtgagt ttctgaaaag ctgctgtcat
     5161 gtttttcacg gattgggtga cataatgaag atatagaaaa gcaggcagca tcaggagggc
     5221 agcggtacaa gccagcagtc cgagccgaac agcatcattg ttgatcatct gtacatattg
     5281 ggcggcggct tcggcaacgg cctgaaccca tccgaaggaa taagccgcca tacctataag
     5341 cagcaataaa agggtaaaga cagtgctttt tttcattgtc tgatcgcctc tttctgagaa
     5401 acgtgaatga tcgctttgtt agaagatgcc attgcatcaa tgagagacaa gaaaacctgc
     5461 gcatccatat cttgaatgat gtggtacatg tcaagaaacg agcaatcgca cctgtcacac
     5521 tcggctgccc actcgaagca tttacgcaca taatcgctgt cataaatgat cgcgtctgtc
     5581 aaagagtcct tgccgtattg aagccaggcg gcaacctgtt ctttcttctg tgtgacatag
     5641 tatgaagcca catcgatata agctgaagaa tgggtccctt gactgtgaag gatcaagaaa
     5701 ccgccatcct catatatata agtctcggct gacaagcgat cgatttccag acggtacgtt
     5761 tgctgaatct cttgaaaaaa cggtgaatct aattgaaata gaatacgagc cgcgatatcc
     5821 caataaagct ttatcaccca cagatcgttt tgcccgggaa gtgcgccgat ctgtaatccg
     5881 gtccatgtat cttccatccg ctcctcatca cccagcatca ttttttgtga gagggctgga
     5941 gggcatgccg ggatgatttt tctttcagca tgataatccg gacgcttttc cagctggagg
     6001 tgaggaggca aaagcgtttc tgtattttct gagcccccaa tcaaaaacag cgtcatccga
     6061 tgggtttggt aggcagcctt ataggctttt tgtaaatcac tgatgtccag cgcctcaata
     6121 tcttcgattc tgcctgcggg gaaaacggca gctggtgagg agggagaaag catgctgatc
     6181 agctgataat gatatgagag ctgatcgtta aggtgtgctg tttgaatttc gcttgtaatc
     6241 acagcttttt cctgagcgac aatcttcttg tcaaatgagt ggttccataa agcatcaagc
     6301 aggatgggga tcgtttgtct gagccgatcc ggtaatgagg taaacatgaa attggtatcg
     6361 gtgtaggtag tgaatgcgtt taaaagcgcg ccatgcgcaa aaaaatcact gtacagattg
     6421 cggccgttat gccagaagag aagatgctct aaaaaatgcg ctgtgccata cggaagcagt
     6481 gtatcaccgg attctgcccg tatacataca tcccggcttc caaaatcgat ttttacattg
     6541 cacagccgca ggtgggcgcg ggggaatttc aatctgaata tttttagtcc gctgtctgtg
     6601 tatctgatat cggttcgttc atccagctgt tgaaaaaagg ctttattttc catctcttca
     6661 tccccttact acatgagctc cgatataatt gatggtcgct atgaattgca atacatcacg
     6721 gcatgtaacc gctgagatgc catccagcaa ggcttctttc gtgcaggaga agcggcgcag
     6781 gatccccata taggccaata gaccttcggg agaatcgaat tgcagcagca attcattgcg
     6841 taaaaactgc tttgcctgtt ctagttcccg ctcatctgta tgaaaagctg agacagcttc
     6901 caaaacgcgc gggggaatgt ctatctcatg aagctgatct gtacatattg aaacaagcag
     6961 caaattgttc atgacatcgt aacgggtgat aacgtgatag actgccagat ccttctctct
     7021 gaagtgcttg aataaagcgg aatggccgta ctttcccagt aatccgtcta ttagctgtat
     7081 tttgatataa tcgctggcat ctttcatctc tccgcagtca aatccgagtg tcaagacgga
     7141 aggacctgca gcgctgcgtg tctctgtttc aaaaacatgc cggtttacgg gtattctttc
     7201 ggacgttaca gcggacgttt gcggggcatg tccccgaaca tcacatgctt gtacttgtcc
     7261 caatatgttc agctgttttt gctgggacac taaatcaacg ataaagtccg ttgcgtcgag
     7321 aaaccgttta ggatgaatcg cctttatcct gtctttccgg ccaaacatgc ctgtgccgta
     7381 catcgggttt ccgaagacct cctcagccaa gcgcgccgcc gagtaggaga aaggatcagt
     7441 gaatttcttt tcgattctca gcagcagctc attcctggcc ttttcaactg cttcgaatga
     7501 aagagaagaa gggaaagaca agtctgcaaa agttttcagc agggcgtcaa catgaagatt
     7561 cccgttatat aatgggtgaa tcaaacgggt cccgcaggtt ttcagctgct gatcaaaaaa
     7621 gagattcgct gagtacatga aacggctgcc ggcagcacaa ccgaaagcgt caataatttg
     7681 ctccttcagg tatgcggcgg cgccgtaaaa ataaatcgtt tcttcctcag gttccgccgc
     7741 gctttcgatc ggtttcagaa agctcgcggc gattgaaata gttgaaaatt gatgagtctt
     7801 cagcaggtta acttccaagc cgttctcttt tgcttgtatc aaagaaacca ccatcctgtt
     7861 tttgcaggta atagactatg accagaccgg ctatcggaat gaccgccaag gatacagcgg
     7921 tgccggctaa tgtggctaag aataggggaa gacaaaacag ataagaccga tattttgaga
     7981 aaccgctcca tagctgctgc tccgtctgcc agctgaagga gggccttttt tcatccgcag
     8041 ttaacctgat aaaagctccc gccagcagca actcaatgca ctgcaaaaaa gtgagaactg
     8101 aaatcggacg gccgctgatg aaacccacaa tcatcacgac aaggagaaat ccgcctgcca
     8161 ataggcctga ataaaagcga tatttcgccc aaaacatcgt tttccgcttg atcggaagcg
     8221 tgataagcag catccggtca tttttttcaa tcgaatacaa aagggcgatc ggcgagcaga
     8281 tgagcaaaag cgcggaaatc acgatataaa ccacttgctg attgaagatg ccggtattca
     8341 tcatctggaa cgaaaagaag ccgctgaacg ccgccattac cgcgtaattt aacagcatcg
     8401 ctttagaaga gataaatcgg ttccattctc ttttgtaaaa cgaaaattca gatcgccgca
     8461 taaatgaatg catcttgctc tgctgcggag gcgcctgcag aaagacagga aagtcaatga
     8521 tcaccgccca cagcatatgc accgcgcaaa gcggaagcgt ggcggccggc atcaaagcgg
     8581 cgctgataca tacacaggcg aatatcgccg catgcagcag aaacatcaag ttcttctttt
     8641 tgacgaagtg gttgcttagc acaactccga aaataatgga gtaaacggta aaaaacgaaa
     8701 acctgccgag ccaaaacaat gtttgcgccc ctgacagcgt tccgtttcca aataagaaca
     8761 gcggtaaaat aaaaaagaat aaagttcttc tcaaacaggt atcgacaaac aaaacgacac
     8821 tctgggcgag ccaaaagctc cgtgaagaaa tcggcagcag gcagctcagt ttcatataag
     8881 attccttcca ttgagatgtc acagaaagaa acaccatata tgcgttcatt aagagaagcg
     8941 cgagtatgat atacgttttg cgcaacaccg attcatcaat gccggcctgg cgaatcagcc
     9001 cgatttcaaa cacggccaga atgacaaggc ctgcggcaat gcggatggcg tcctttttcc
     9061 cttgccggct gtaaagctgt ttgaacagca aagacatgat ggggattatg ttattcatgg
     9121 ccgatcacct cgaaaaattc ccgccgcaga tcggtctcct ctccaatcgg aatgaccttt
     9181 tggatctgtt tgttgtgaag aatagccgca taatcacaaa atctttgcac gacatcgagc
     9241 agatgagaag aaaacaaaat ggtcccgcct gcttcacagt actcgcgcat tttctgataa
     9301 aaaacctcta tcgattccac atccaaaccg acgagcggct catccaaaat aaacagggga
     9361 gcgcgcagca ataagcctgt catcaataca accttttgcc tgttccccaa ggaaagctcc
     9421 gaaattctcc tgttgatgta tttcgaaaaa tgaaaggcct cggccaaact ggcaaactgc
     9481 tgctctgaaa aatccttttg ataaagcgaa tggacgaaag acacatagtc cttcgccgta
     9541 atttctgtaa atagcagcgg ataatcggcg gcgaagtaac ggtgagtctt cagctgatct
     9601 gatgttttct gcggcatgcc ggcctccgct tcaattccgc acagtgtaaa gcgcccgctg
     9661 aaattgcggt tcacgcctgt cagcgtatta atcagtgtcg tttttccggc gccgtttacc
     9721 ccaagcaacc cgtaaacggc gcctttttct aaatgtaaat ccacttgttc taagatgacg
     9781 ttgtcccgtt cataccaaac ggatacatcg tgtatatcca aaatgctcat cgcgagtcag
     9841 ccttccgcgc gcgaatcccg aacagaatgg caatggcaat gaaaatcagc gtaaacagat
     9901 agtcgctttt gacaaaatag acgactgcgc cgatgacaaa gataaatgaa aggatataca
     9961 gtaaaattct tctttgtgct ggtgacaaat cgtttccctc ctaaataagc tggaccacgt
    10021 cttctaattg ttcatttttc gcccaagagc aaatgttttt tcggtgatat ttgttagagt
    10081 tcagcccttt taagtaacag cctccgcaat agccgctgaa cgggcatttg tctttcatgc
    10141 aatgttcact gaaccgcggc gcctgcgctt gccacagttt atggacgaga ggggagttaa
    10201 agatgctttc ataggaatca tgaaaaatat ttcccaatga aaattccttt ggaaagaggg
    10261 cgcaaggacg tacttcgccg aacgggctga tcacaatgga cttccagcca gcgccgcaat
    10321 ttgccgcgcg ttttctctca tagggaataa tcggaatcag atctttaaac tcatcaatca
    10381 cattttgctc gtattccata aacttgcggt gctgctcggc gtctttcgtt ggatgggcaa
    10441 tatccctgcc tcttccgaaa tcgtcaaccc aattgtaaga aaatgccttc gccccgagat
    10501 cccgaacctt ttgggccata tcgtggattt cccacatgtt tttttcgaag acagacatgg
    10561 cgactctgac aaatataccg tggtcactca acaattttat cgttttacaa gtttgggcaa
    10621 aagagccttt tctccctcta aaggagtcat ggacctcgga attgacacta tcaagagaaa
    10681 tgccgacgat gattttttgc ttgtaagtct tcaaaagctc caggctctct tttcgcatga
    10741 gtgttccgtt tgttaagaca gcgacttttt tgaacttttt acacacatag tcaagaatct
    10801 cattggcgtt tggatggaca aaaatttctc cgcctgtgat ttcgcatgtc aatacaccgt
    10861 tatcaaacag catatcagcc gtttttttga attgctcaat cgacacggtg ccgagcgctt
    10921 caggtgagct ttccaaataa cagtgggcgc atttcaaatt acagcggtgc gtcagttcaa
    10981 aggtggcgtg caggggcatc ggaaattcat tgctgccgct cgtggtgatt gtatggcggc
    11041 tggcccggtt tccaagctgg atcacctgct tgttctggag catgttaagc atgtcgtaat
    11101 accaatcttt atggtcttcc ggtgattcat catacactgc acattgctca gctaaaatct
    11161 gctcagctgt tttttggcca tccatgcgca tgcagagctc gtaagccgtt ttgttgagat
    11221 ccaaatactc aaagtcagaa atggagacat tatcgcgcaa gtagtcgatt tctaacacgc
    11281 cgccctcagg aagctggtga actcttacac tttcattaat aaatggaaac atctgctcta
    11341 taaacaaaat accatcccct atacatatga ttcaaatgaa aaacggttgt gtatgtatat
    11401 ccaagaggta gattttagtt aaaaattgta atttacttaa aaagggcata gtagaatgac
    11461 tatgcccttt tgggagatcc ttacccccat agaccgaata gacctgttgc accggcaatt
    11521 tcaaaatcag ggataggacc gtccactaga caagcggctc cgatcgagca tgttgcacaa
    11581 cctttgtttt ctacaatgac agcttttttc ataattgaat cctccctttt tttgtttttc
    11641 tagcagatct atgttgtact tttatcttaa aactatcaaa ttactaattc aatgcatata
    11701 ttttgaaaaa aatgtgaaaa ggaaatgata gatttcggaa aaatgtaaca tttcctaaag
    11761 gtaattagtg atatgatttt ctcttctata taaggaaatg ctttttatga ggtttatctt
    11821 caaatctgat gagcaatgat ggtaagatag aagcagttga agtttacaaa ccgaatgatt
    11881 atactattca agtcaaagtg gaatgatgaa aaggacgtgt cagaatgaag caagagacac
    11941 cgataacact ccatgtgaag tctgtgatcg aggatgacgg aaaccaagaa gtcatcgaat
    12001 tccgcaccac cggattttac tatgtaaaac aaaataaagt gtatctatct tattatgaag
    12061 aacacgactt aggcaaagtc aaaacgattg tgaaagtaag cgaaggcgaa gtcctggtca
    12121 tgaggtcagg cgctgtcaaa atgaatcagc gtttcgtaac gggagcttcc acaattgcta
    12181 aatataaaat gtcatttggt gagcttgagc tgaaaacaag cacaaaatcg attcaatctg
    12241 atctcgatga agaaaaaggc cgtatcagca tcgcatatga catgcatgtc ggagacgagc
    12301 aggagcattt acataatatg acgatcacgt atgagggagg aactcacgca tgaacattgc
    12361 ggaacaaatg aaggacgtgc tgaaagaaga aatcaaagcg gccgttctga aagcgggact
    12421 ggctgaagaa agccagattc ccaatgttgt tttagaaaca ccgaaagata aaacacacgg
    12481 cgactactca acgaatatgg cgatgcagct ggcaagagtg gcaaaaaaag cgccgcgtca
    12541 aatcgctgaa gagattgtcg ctcattttga taaaggaaag gcttcgattg aaaaactgga
    12601 tatcgccggc ccgggtttta tcaatttcta tatgaacaat caatatttaa caaagctgat
    12661 tccgtctgta ctggaagcgg gggaagcata cggggaaaca aacatcggaa acggtgaacg
    12721 agttcaggta gaattcgtat cagcgaatcc gacgggagac cttcacctcg ggcatgcgcg
    12781 cggggcggct gtcggcgatt ccttgtgcaa cgtgctttca aaagcgggtt acgatgtaag
    12841 ccgcgaatac tacattaacg atgcgggaaa ccaaatcaac aatctggcgc tttctgttga
    12901 agtccgttac tttgaagcac tcggattgga aaaaccgatg ccggaggatg gctaccgcgg
    12961 cgaggatatc attgcgatcg gaaagcgtct cgctgaggaa tacggtgatc gtttcgttaa
    13021 cgaagaggaa agtgaacgcc tcgagttttt ccgtgaatac ggcctgaaat acgagctgga
    13081 aaagctgcgc aaggacttgg aaaacttccg tgtgccgttt gatgtgtggt attcagaaac
    13141 ttcactgtac caaaatggaa aaattgacaa ggcgcttgaa gcgctccgcg aaaaaggcca
    13201 tgtctatgaa gaagacggcg cgacttggtt ccgttccacg actttcggcg atgataaaga
    13261 ccgcgtattg atcaagaagg acggcacgta cacgtacctt cttcctgata tcgcgtatca
    13321 taaggacaag cttgaccgcg gctttgataa gctgatcaac gtttggggcg ccgatcacca
    13381 cggctacatc ccgcgtatga aagcggcaat cgaagcgctg ggctatgaaa aaggaacgct
    13441 tgaagtagaa atcattcagc tcgttcacct ttacaaaaac ggcgagaaaa tgaaaatgag
    13501 caaacggacc ggtaaagccg taacgatgcg tgacctgatt gaagaagtcg gcttggatgc
    13561 cgttcgttac ttctttgcga tgcgaagtgc ggacacccat atggattttg acttagatct
    13621 tgctgtatca acatctaacg aaaaccctgt gtattatgca caatatgcac atgcccgaat
    13681 ctgcagcatg cttcgccaag gggaagagca gggacttaaa ccggcggcgg atcttgattt
    13741 cagccatatt caatcagaaa aagaatacga tctgctgaaa acgatcggcg gcttcccaga
    13801 ggcagtggcg gaagcagcgg aaaaacgaat tccgcaccgt gtcacaaact atatttatga
    13861 tctggcctct gctctgcaca gcttctacaa cgcagagaaa gtcatcgacc ctgaaaatga
    13921 agagaaaagc cgtgcgcgcc tggctttaat gaaggcaacg caaattacgc tgaacaatgc
    13981 gcttcagctg atcggcgtat cggctccgga aaaaatgtaa tcacgatcaa aaggacaaag
    14041 tcttcgggct ttgtccttag cttgtagaga aaacgacgtt ttttctacaa gcttttttgt
    14101 tttatacagt ttctttagat attcatcagg tttcagatgc agaaaaagcg ctcccacatg
    14161 cctagccctg cttggctagg tatgtggcaa ttttcttcat gttctggcat gcggctgtga
    14221 ggagaacttg
//
