LOCUS       gnlProkkaJNFPGMDP_12   25041 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JNFPGMDP_12.
ACCESSION   gnlProkkaJNFPGMDP_12
VERSION     gnlProkkaJNFPGMDP_12
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 19:06:35
            Original ID  :: gnl|Prokka|JNFPGMDP_12
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 41698
            Orig. end    :: 66739
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     cand_cluster    1..25041
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="neighbouring"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..25041
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     protocluster    1..20606
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10606]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10606
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..20606
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     CDS             1408..1713
                     /locus_tag="ctg12_64"
                     /transl_table=11
                     /translation="MEESRLMKYEIDENGYIIKGYEPDAKDIPDGVVDAWEGSGFFKPR
                     YDREKRQWVEGATQEEIDEILKGTNPIDEPVSEVEQMKEQILNLQRMCNVLMANQP"
     CDS             1728..1898
                     /locus_tag="ctg12_65"
                     /transl_table=11
                     /translation="MENRSAFYNFFEDCWKNGTVLTIELKTHVQKERITQAEFDEITAL
                     ERGNAYPDQTE"
     CDS             1911..2168
                     /locus_tag="ctg12_66"
                     /transl_table=11
                     /translation="MEEKQSNNMELQEKVELFELKAATYQQKWLTAEDTLMTYSYMASK
                     DKELLKKQEDEIQQLKEHIEKLEKNLNNLKGPVKLDHQKN"
     protocluster    1970..25041
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11969:15041]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      11970..15041
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
     cand_cluster    1970..25041
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="2"
                     /tool="antismash"
     CDS             2245..2523
                     /locus_tag="ctg12_67"
                     /transl_table=11
                     /translation="MSEVTEVPDVHALQKEIMEMKAGQKTIEQRVNVLERVSDRQDQQI
                     MTLNEKLNKIEENTTWIKRTITGAIITAVCTGVIGGAIAIFYTVLQK"
     CDS             2539..2802
                     /locus_tag="ctg12_68"
                     /transl_table=11
                     /translation="MKNFDKGTVVRTVLLLIALINQTMLMFGKSPLDITDAQVNQLADA
                     LYTAGSIAFTIGTTFTAWFKNNYVTAKGHQQKAVLKNHNLTK"
     CDS             2856..3677
                     /locus_tag="ctg12_69"
                     /transl_table=11
                     /translation="MTIAVKKNLVSEAKYALKCPNHMDAEYITIHNTYNDASAANEVSY
                     MIGNTSSTSFHFAVDDKEVRQGIPTDRNAWHTGDGTNGTGNRKSIGVEICYSKSGGPKY
                     RAAEKLAIKFVAQLLKERGWGIDRVRKHQDWSGKYCPHRILDEGRWNEVKAAIDAELKA
                     LGGKTSSKKITSSKTVKKPSSSKKKSSFNLPSGIFKVKSPLMHSDAVEQIQTALSALHF
                     YPDKKAKNFGIDSYYGPKTADAVRRFQLMNGLKADGIYGPKTKAKIKGLLK"
     CDS             complement(3716..4015)
                     /locus_tag="ctg12_70"
                     /transl_table=11
                     /translation="MIDTNISEPVFQFLGGIFHQDIETPESALDEYLEEIPKEEQETDI
                     LALKDFINSDYTDEEKNDFIDEAADGVDIRSYGVSPLVWLEQVIQKIEKNIETL"
     CDS             complement(4020..5900)
                     /locus_tag="ctg12_71"
                     /transl_table=11
                     /translation="MKVFEAKSLLSEADRRAKEYKELRSQMVNLKKAFKAVADLDDSEF
                     SGKGADNIKAFYQDHAGVADNWIDLLDMKIAFLTSISGTLEDASLSDAYIEESFLEHEL
                     ANAYTKSKAIMSEQKKAMKDILHDIDDILTLDLFSTEDFKDELADAEDKRKKTVNKLDS
                     VDQALVTEYAQSEPNEQFIKKDFQKLEESTGKGNNATPIHYNAKAYRESDIHKRKGDIE
                     KQTEAYLKIKRDEAKEREIKELKRKLADGVTDPDEYLEIAKKVGYENLTHEQLQYVVQL
                     EQVKQLKTAGESVINAGKATIDFIDGVNNGIDDVIDDTIYGVKDLVVGAWEYSQLPTEL
                     KLTKTISTVLSVPSYSKIIWTNLVDSWNDKMINGDAYEKGHYISYAIGNIVGPKGAGAA
                     VQTTTKLSKVGKVVEGGTAAAHVNKGINKGKAYINSIVRNKNDLALVGIAQDFDNTYNA
                     KNTPLLKSIIEDKKESVLRKSETSNNIGIGNVKQGDSTPLAPGGGLAAHEAKGGHLIER
                     HVGKTDEELIQRLDKSKMSNKKISGSSSFKDRATAERVANSALTNNKVKIEKWLNSDVK
                     KPLVLSYKGNEVLGRGIPKGEDTITDLTNAKIILKKNKDGSFILTGYPTR"
     CDS             complement(6092..6316)
                     /locus_tag="ctg12_72"
                     /transl_table=11
                     /translation="MKRSSSIEWQFNIKVEKSKKIDTTRFQFDLSGYENCTFQIQNSFY
                     KCKELFPSKERAFHFHFNFASSFAFVVGP"
     CDS             6662..6904
                     /locus_tag="ctg12_73"
                     /transl_table=11
                     /translation="MLIPLYHVHDNMKKYFKQYSTADFAVLLILVAGIVAIDLTDEGMS
                     GKIAHTVLMIAVVITLLKGFIMMWRESRHERKRKN"
     CDS             6882..7112
                     /locus_tag="ctg12_74"
                     /transl_table=11
                     /translation="MKESEKIKFIQEEVLTAAEAGELLGITRQRLSTLVTSGKLNPVKK
                     VGTVALFLLGHVQALKKELEAGRKKYRPYDK"
     CDS             7363..8010
                     /locus_tag="ctg12_75"
                     /transl_table=11
                     /translation="MNISVAAMYLISKSEPNTKYEITPKKLQKILYYAQAWHLVNEGKT
                     LFENEDFQAWSHGPVHYPTYNEYKCYRYSSIPPVEFSEELDLHPFSQKEKNHLDSIWKV
                     YGEYSADDLEHLTHEEDPWKITRGGLAPEAPSNEVIPEEIISMYYAKVSNDVLAGKWKS
                     PLNPAPRLEWLITPKRKTAVNPLLKYVGTWSGNDLDECMEEVYNNRAEVQFH"
     CDS             8014..8505
                     /locus_tag="ctg12_76"
                     /transl_table=11
                     /translation="MLLLDTNHCSGIIGENPDVKAELQKCDYERLCTSFISEAEMYFAA
                     YRSERCIENLYNVEAFLSAMIIYTCDAKISKTYGELKSKILFHFGPNERNKRRKYTLQK
                     AGIGENDLWIASVAIAHDMTVLSCDRDFKRIQEVEPNLKVESWIKQTPIVSEETVTSDV
                     "
     CDS             complement(8567..8755)
                     /locus_tag="ctg12_77"
                     /transl_table=11
                     /translation="MTDFERKVYQIIVNMHLYGKNPTLNDLKRKTGKNEEDIRAAVKSL
                     LMKRELKWDKLQKKWIM"
     CDS             complement(9435..9893)
                     /locus_tag="ctg12_78"
                     /transl_table=11
                     /translation="MLMNPNYPKIKRVMNIDRQIIDDDQEILNFFKKISNEISQARFDL
                     ITSKISDLISHLESTQEVDLVIIDVNMPQNNGFDVAEYINIHYPFTSIIFMSYLPDYAL
                     DGYKYYPMDFMVKPVNLLRLKSTVSLVNNHKSRRKKRSVLAQMVKFIS"
     CDS             complement(10001..10606)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_79"
                     /sec_met_domain="AgrB (E-value: 5e-30, bitscore: 97.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDLTPHKLAKKISKHIIHFNPEFRRLQDNIRYGLEWMLATVNQV
                     FIVIILAEFFGYLAQALIVLASGGLFRMISGGSHFKNYNLCLIFSTLQILFITYISIEF
                     ESHFTFWTKSVLKILLVFSFFITFKNSPKLQKKKHLFTPDHKKKLKIGSIGIFSCLLLI
                     SLMGDDHHKYGIWMALILQSITLTNIWDKILLSLDKRF"
     CDS             complement(10599..11306)
                     /locus_tag="ctg12_80"
                     /transl_table=11
                     /translation="MTMFIFFMIRGIFLQNLRDAEDYLEEQYEEVGKYIHFIQRHNHDH
                     MHHLITIKQMLEKGYSKESYQYLSDVLNDSAQISDILPLHSVAISGLLLSYKDKGLKEN
                     IHIQYKISDSLRGFPCKLFETNRILGNLITNALDAVKEIDELPKRAVYVHINATENYYR
                     IDVSNFGDIERFSEVIERIFEEGFSTKDKVGRGYGLHIVKSVVEKYNGFIFTEIIDRMI
                     IFKVRIPKEADYV"
     CDS             11574..11789
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_81"
                     /transl_table=11
                     /translation="MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGAADVTPH
                     TTPSSLPCGVFVTAAFCPSTKCTSSC"
     CDS_motif       11574..11690
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA"
                     /locus_tag="ctg12_81_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11691..11789
                     /prepeptide="core"
                     /locus_tag="ctg12_81_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.80"
                     /molecular_weight="3018.4"
                     /monoisotopic_mass="3016.4"
                     /core_sequence="ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA"
                     /leader_location="[11573:11690](+)"
                     /alternative_weights="3036.4"
                     /alternative_weights="3054.5"
                     /alternative_weights="3072.5"
                     /alternative_weights="3090.5"
                     /alternative_weights="3108.5"
                     /alternative_weights="3126.5"
                     /alternative_weights="3144.6"
     CDS             11970..15041
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     938.5; E-value: 7.6e-284)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_82"
                     /sec_met_domain="DUF4135 (E-value: 7.7e-109, bitscore:
                     357.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9.2e-66, bitscore:
                     215.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAFKRSAYLNERETVRKTTTLDHIKELSEWTNAIPHEMLEKRL
                     EKDHLTREQLMLHIEQKDSPFIKKELKWIETFEELMDTYETSPLDYLSFQSLIHPFIIY
                     AKKQIECLFKKVTSNLINIETVTQSITDALYARLHIMVMKCVILEVNIARKIEVLEGDT
                     SEERFQYFMRQFNEDSEMRMEFFENYPVLSRLMTESTKNYLIITEELIERFLCDYEKIK
                     DNFEGEFTRLERIKMDLGDTHQNGRTVAILEFESGEKLVYKPRQILIYKCFESLLDWLN
                     DRGLKHKLKAAKSLDCQTYGWQEFVPFKECILKEEIRRFYYRQGVYTALFYVLGSSDFH
                     AENIIANSEYPVPIDLETLFSQNLEMTKKLNFQSQLAVELNDSVFSTLMLPLPSLEHSI
                     IDFDLSALGAIENQVSEKIKSIRIEGEGTDEIRITRGPAKSGQYHNRPVLEGETLSPSD
                     YITDLEEGFTDLYRLFLKHKNEFISDDGPLQPFGKAHVRQVFRPTHVYSEFLQNSLHPD
                     YVQNGLDRVQLFDILWQIYKQSSKFEELVIYETKDLLRHDIPYFYFKLNSRDLYDSNGN
                     LIPNFFTETGLEAVFKKVSQLNRIDLEKQKQYVRWSLVSMLGEVWRFPEKVLTFQERTE
                     ESSSSFTQEALEIGRLLVDRAITEENMEVNWIGLNLNDKAGLSVSVKGPDLYDGLIGYA
                     MFLAYLSKETNNQEYEKMSRGAIQTVIRKVGNKPLNESISAFSGEGALIYGLVHLGLLW
                     NDQELIKQAKVRLHYVCDIVRKEKSLDFSGGLAGFIVLCLNIFNEIRDYDYLNVALQAG
                     DQLMIKMDDTARKPGLAHGIAGYAWALGLLGEVSQEEKYQIEAQKLLVYENTFYDGSTG
                     NWEESESKKKSERKRVYWCHGAPGIALSRIMLKDIINSKDIKEDIDVALKTLISEGGIE
                     SHCLCHGTMGNVDILLTAAKELNEELFMIQALELTKIALDQKKVHGWVHGLDPRAEMDG
                     FMLGRTGIGYCLLRLKNPSIPSVLALQLPKGENL"
     CDS             15038..17185
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 282.5; E-value:
                     1.1e-85)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_83"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.3e-42, bitscore:
                     137.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRSPFKTHSRIPFIEQMQQTECALCCMAMIASYYKNDLSMYEL
                     RERLGNGRDGTTLLHLRNMAKQLKFETKTYKADTKQLRNLVLPAILYWDNNHFVILEKI
                     TSHALIIVDPGSGRKKVKEKDFTEKYSGYALTLYPGNGFEQRKRKNIWTSFSFLVTNRP
                     KIFSAILFLTFLLQLFTVAMPVLIQFVIDRIIVPDYRELLNAFLIGICGIILFHSLFSF
                     IRGKILINLHNVLDYDIQSRFFKHLLKLPYQFFLLRSFGDLLFRANSMKVIRDQIVNQV
                     VKGLLDSAVILVILLYMLIQSPLLAVIVFLIGTSNVLLIALSQRYISEANQMEIKGHTE
                     VQGAQTEMLYGIFGVKTSGVEKMIYDRWLYRFKNLLCAYRKKENVLNYVNTASSTLQLM
                     APLIILWVGAHQVFTGSITLGMLVAFHSISTQFFMLSGNIVQTINSFILTTSYLKRVGD
                     VLDAPTESREDKMKKTLNGDIQLKNVTFAYSKYSENVINNVSLNIKKGQKVALVGQSGA
                     GKTTIANMIIGLFSPTDGEIYYDGISINELDLGHLRRQIGTVPQNVMLFNRSIYDNITL
                     HNPEATPEQVIEAAKAAQIHDEIMNMPMQYHTMVSEMGMNISGGQRQRIALAKALLGKP
                     SILVLDEATSSLDHLNESKIDAYLSGINCTRVVIAHRLTTVMNCDLIVVVDKGRIIESG
                     SHHELLRISSFYSQFYKEMIS"
     CDS             17296..17598
                     /locus_tag="ctg12_84"
                     /transl_table=11
                     /translation="MSIEEIAKYGNSIGGVIVLLCVAIIWVVSKQMGKDERSNAIFLRV
                     YCFMFYVLAGLILLSIFFEIGEGISGQVYQELTVLMFALSTLFGTIYLFILKKKF"
     CDS             17655..18575
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 173.1; E-value:
                     1.3e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_85"
                     /transl_table=11
                     /translation="MGRNRYIVETHGLTKTYRGTDVVKSLNLKLREGEIYGFLGPNGAG
                     KTTTIRMLLGLINPSKGETRIFGKELKNNRLEILQSVGSLVESPSYYPHLTGEENLETV
                     RRILNIPKKNITDVLELVRLTKMADRKVGEYSLGMKQRLGIAAALLGNPKLVILDEPTN
                     GLDPAGILEIRKLILKLPSEYGITVMISSHLLSEIEQVATQVGIIANGEMLFQDDIATL
                     RSRADTKIVFSTSDSDKALKVFLKEGVEAIKTQHGLMIEERTDKEISELAKKLVHNEID
                     IFRISDEAKSLEDIFLEMTRGGETL"
     CDS             18572..19279
                     /locus_tag="ctg12_86"
                     /transl_table=11
                     /translation="MIAKLLKSEILKIRNLTWLIVILGPLGVVVMQAANYTMRFDYLMS
                     KSSDKWMFLLENIHSYWPSALLLEITIVNSLLAGIEHHGGMWKKIFSLPVSHWKVYQSK
                     VIIIVTMLIISTVILAGGTFLLGKLIGFHETFPFGSTLKMSFYTFIAALPFVFMQFWLS
                     INYRNQGIALTIGIASAVFIMYAQGLPDWMPWKWPMLIEGIGESILSVIKGLVFGLFLY
                     SIIMVSLSRKDVA"
     CDS             19281..20021
                     /locus_tag="ctg12_87"
                     /transl_table=11
                     /translation="MFFQLLDTEWLKLKHSKIWFIVLASPVLAAIIGFFPVFKIGTNEW
                     LTLCTQMILAHSALFLPLLTGVLAALICSNEHAYGGWKQLLALPVKRIQVYLAKYVIVM
                     FMLLWTQIFFIISVWFVGTVKGFSSPFPWNGVIMSALMGWVSCFPLAALQFWLATYFRS
                     FAGPSTVNVMLTLPAIIIANSKFMGPLYPWAHPMLSMTQAFSAAIGGNAGFLENEPTFY
                     VTLIVSFILFFFGGALYFHKKQWT"
     CDS             20046..20276
                     /locus_tag="ctg12_88"
                     /transl_table=11
                     /translation="MQKNKQSKKLTNRLPEWRARTKLTQQQLAEKTGVSRQTIISIEKM
                     KYTPSLALAFEIAQALSCSIDDVFQYNEENE"
     CDS             20301..21215
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 183.1; E-value:
                     1.1e-55)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_89"
                     /transl_table=11
                     /translation="MIIETKGVTKSYNRVDVVHEVDMMVPEGEIYGFLGPNGSGKTTMM
                     RMLLGLVRPNRGVIRMFGKKMPEDRISILAKTGALIEKPAYYEHLDGRDNLRVLAALRG
                     INDNKTIDRALERVNLHRVGRKKVKSYSLGMKQRLGIASAMLHNPRILLLDEPTNGLDP
                     EGIFEIRELIRNLSEKEGVTVLISSHLLGEIEHAASRIGIIYNGNLLYQGKMNELLTHQ
                     KMGSFIIESNMIELIINALQAYDIQTSLDGEGKVQVRGSEADRDRIKKILVEKGLTDFH
                     IYDSMRTLEEAYLELIRSQKVSV"
     CDS             21212..21922
                     /locus_tag="ctg12_90"
                     /transl_table=11
                     /translation="MKNIIKAEWRKKRSTVFLIPLLVGSLLIFAICGSIMLSLTKNGQS
                     IDRAFEVLYELCVTNWNYLVILVVITFSLLATEMEHRLGMWPTLLTTPHSKWKHFFVKV
                     ITAVGFIQLFGLCVCLYLSGLGFLYGKSFFEYIKISLELLYLPFLLAIPFVITQTLISI
                     IIVNPYISVGIGMAVFLFHAMLPYWWLPWGALAYMQSNTRIIEVFPLLISLSLGYGVLS
                     IFVFCRKMFSSGGE"
     CDS             21924..22688
                     /locus_tag="ctg12_91"
                     /transl_table=11
                     /translation="MVGFQQVFFAEWIKIKKKKSLLLIIILVALPVIYGWIIHTKVMIE
                     TYGYDEGNSWKVLIMMTQMFYGTVFFPIIISLVTGTLTGYEQRANSWEHLLMTPVKGVL
                     FFFSKMAWAGIIILSTQLLMIGLLIVLGYTAGYTDKLPMDIFLFTVLFGTVGGISLGTL
                     LFYFYLRMKSIRQSLLISIFLSFPSFLAFSNSSGSWIPMLYPWALPLYGMTNVYADWGR
                     VGIFIIVCVTMTIVFSLLSVRLLNRKVIDLKN"
     CDS             22783..24177
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 244.3; E-value: 4.9e-74)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_92"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.4e-46, bitscore:
                     150.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRVYILMLLLLGCVLVIPHHALAEDNRLNTYTVFLKSPTYEKNW
                     IKALERKGIKLEYDVEEIGLYEVKAEREKFEALMADINYVDSYNEAVSIKPAELTRISK
                     ENFTDQDEDNSLWEYQWDMKKATNNGRTYEITKGSKKTVVGIIDSGIDKNHLDLKDNVL
                     SVSNFVPKGGLRGQEPYENGEINNSTDYLGHGTFVAGQIAANGQMKGIAPETGIRSYRV
                     FGGKSADTVWIINAIIQAAKDDVDVINISLGTFLVNSKGKNNGKPVTDDLAEIKAFRKA
                     VAFAHRKGSAVVASIGNEGLNLKDKKAVYDYWKNNINQEGRFMNAKVILIPAQLPNVVT
                     VASVGPNGNRSVFSNYGKNIADIAADGGDHRILNEVGAEKYYQEGLFRQEYILGAAPGS
                     SYTFSVGTSIAAPKISGALALLIDQRYLHDKPDKGIRILLKNADKYDSNDYIGKGVLNI
                     YKALID"
ORIGIN
        1 ccgaacaacc tgaacgactt gtctaactat ccttctgatg aatttgtaag atttgatgta
       61 gtatttaatt cacccgcaac attaatagat gggcgtattt gtctaggggg cagaactaca
      121 aatattgcag atagcgggag ctttacagtt cggaaagtcc aaataagaaa aggtaacgtc
      181 cgaaaggatt ttggttttag cccgtatgat acacagttaa ctgatggtgt tatcacctct
      241 gccttaatag cagaagccgc agttggctca atagccatcc aaaatgcggc catcaactca
      301 gcaaatatag ccgatgccgc aattacatcg gctaaaattg ctgaagcggc cgtaggtact
      361 gcagcaattc aaaatgcagc gataacaaaa gcacatttaa agacagcaat tatcgacact
      421 gcacatatta ttgacggagc tattacaaat gccaaaataa aagacttgtc agctgataag
      481 atcaacgtcg gtacgctcaa aggtattacg attgaggggg ttgtgattcg tggttctcgt
      541 ttcgagacaa cgggttccag ttctctaaaa tcatacatcg aagccaatgt tataagccaa
      601 tatagaaaat tcaattacag tgattacgaa gaattgacta ttacatctgg aagtatagtt
      661 caagaatacg gatcgttaga taacagcgac aataaagaaa tgaagaaaaa agccgaagtt
      721 tcgaggggtg ctgttaaact ttctaacggc cctgacggtg cgagcgtaag aatggaaata
      781 gccgccaaag aaaacaggga atctactagc ggatatgatg gggcatacat tgaaatttat
      841 cgcgatgatg ttaaaaggct atctatattg tacgataccc tcacggtatc agacccttac
      901 gaaacattta gaattttagg taaagaggtc gattggagat gggcggccag aagcttgtat
      961 atgagcggtg agcaaaacat tgaattctac gctaacggaa aagcgagcat ttattcgaaa
     1021 aataaagggt ggaacaggat atctttaacg ccatttttca cacatactgg tggccagtgg
     1081 ggttatgctg actggcgata caatgaatat ggattcgttg aactacgcgg agaagtaaaa
     1141 ggaactacct acacaggtga tcttgaaatc gggaaaatcc ctacaccaga cagaaacggc
     1201 gcgtggattt gctccaatgg ccgtaatggt ttgcgtgtac aagtgactgg ggcagataaa
     1261 atggcctatg attcaggcgg ctcattagct gtccgggggt ttcaggcggg cgcgataaac
     1321 ctaaacggaa tcatgtatat gcctaaacca accgggataa acggaaaatg aataccctac
     1381 ggaacaattt aaaaagggga gatgaaaatg gaagaatcaa gattaatgaa atatgagatt
     1441 gatgagaacg gttatataat caaaggatac gaaccagatg caaaagatat tcccgatggc
     1501 gttgtagatg catgggaagg ttcgggattt ttcaaaccaa gatacgacag agagaagagg
     1561 caatgggttg agggtgctac ccaggaggaa attgacgaga ttttgaaagg gacaaacccg
     1621 attgatgaac ctgtttcaga agtcgagcag atgaaagagc aaattttaaa tttgcaaaga
     1681 atgtgtaatg ttttgatggc taatcagcct taataggagg gtattcaatg gaaaaccgga
     1741 gcgcatttta caactttttt gaggattgtt ggaaaaatgg aactgtacta accattgagc
     1801 taaaaacaca cgttcaaaaa gaacgcatta cacaagctga atttgacgaa ataacggccc
     1861 ttgagcgcgg aaacgcttat cctgatcaaa cagaatagga gaacgctaat atggaagaaa
     1921 aacaatcaaa taatatggag ttacaagaaa aagttgagtt atttgaattg aaagcagcga
     1981 cttatcaaca aaaatggctt acagctgaag atacattaat gacatacagt tacatggcca
     2041 gtaaagacaa agagcttcta aagaaacaag aagatgaaat ccagcagctg aaggaacaca
     2101 ttgagaagtt agaaaagaac ctgaacaact tgaaaggtcc agtaaaacta gatcatcaga
     2161 aaaattaagc ggcgaagaag cggctttttt attttgcctc taaggaggtg aaaaacgtga
     2221 aatagatata aggggggcgt actaatgtca gaagtgacgg aggtaccaga tgtgcatgca
     2281 ttacaaaaag agataatgga aatgaaggcg ggccagaaaa cgatcgaaca gcgtgtaaat
     2341 gttcttgaac gcgtttctga tagacaagac cagcaaatca tgacattaaa cgaaaaactc
     2401 aacaagatcg aagagaatac aacttggatc aaacgcacaa taactggcgc tatcattaca
     2461 gcggtatgca ctggcgttat tggcggcgca atcgctattt tttatactgt tttgcaaaaa
     2521 taaggaggaa aacacaatat gaaaaacttt gacaaaggca cggtcgtccg gacggtgctt
     2581 cttttaattg cgcttatcaa ccaaacaatg ctgatgtttg gtaaatcacc cttggatatt
     2641 actgatgcac aagtgaacca acttgcggat gcgctgtaca ctgcgggctc tatagccttt
     2701 actattggca cgacatttac agcatggttc aaaaacaact atgtgactgc aaaaggccat
     2761 cagcaaaaag ctgtcctgaa aaatcacaat ctaaccaagt gagctgccag ctggcggctc
     2821 tttctaattc aaaaacagaa taggagagat catttatgac aatcgcagtg aaaaagaacc
     2881 ttgtatcgga agcaaaatac gctttaaaat gccctaatca catggacgct gaatacatca
     2941 ccatccacaa cacgtacaat gatgcatcag ctgctaatga ggtcagctac atgattggaa
     3001 acaccagttc aacgagcttt cactttgccg ttgatgacaa agaggtaagg cagggcatcc
     3061 caacagatcg caatgcatgg catacaggag acggaacaaa cggtaccggg aaccgtaagt
     3121 ctattggcgt tgaaatctgc tacagtaagt caggagggcc taaatacagg gctgctgaaa
     3181 agttggctat caagtttgtt gctcagctgc ttaaagaacg cggatggggt attgatcgag
     3241 tgcggaagca ccaagattgg agcggaaagt attgccctca ccgtatttta gacgagggac
     3301 gctggaatga ggttaaagcg gctattgatg ctgaattaaa agcacttggc ggcaaaacat
     3361 ctagcaagaa aataacttca tccaagacgg tgaaaaaacc aagctcaagc aaaaagaaat
     3421 catcctttaa tctgccttca ggcattttca aagtaaaaag cccattgatg cacagcgatg
     3481 cagttgagca aattcaaaca gcgttatcgg cattgcattt ctatccggat aagaaagcca
     3541 aaaacttcgg tatcgatagc tattatggtc caaaaacagc agatgcagtt agacggttcc
     3601 agctgatgaa tggattaaaa gctgacggta tttatggacc gaaaacgaaa gcaaaaatta
     3661 aagggctttt gaagtaataa aaggtccctt gaattttcaa gggacctttc atggattata
     3721 aagtttcaat attcttttct attttttgaa taacttgttc gagccatact aatggagata
     3781 ctccgtaact tcgaatatct actccgtcag cagcttcatc gataaaatca ttcttttctt
     3841 catccgtata atcactgtta ataaaatctt ttaatgctaa tatatcagtt tcttgctctt
     3901 cttttggaat ctcttctaag tattcgtcca gtgctgattc tggagtttct atatcttgat
     3961 gaaaaatacc tcctagaaat tgaaaaacag gttctgaaat gtttgtatct atcatggtat
     4021 cacctcgttg ggtagccagt taatataaag ctaccatctt tgttcttttt caatataatt
     4081 ttagcattag ttaaatcagt aattgtatct tctccctttg gtattcctct tcctaaaact
     4141 tcattccctt tataagagag tactaaaggc ttttttacat cactatttaa ccatttttct
     4201 attttcactt tattattagt gagagcacta ttagcaactc tttctgcagt tgctctatct
     4261 ttaaatgatg atgaaccgga tatcttcttg ttactcattt tgctcttatc aagtctttga
     4321 attagttctt cgtcggtctt cccaacgtgt ctttcaataa ggtgcccgcc ttttgcttca
     4381 tgagcagcta accctccacc aggtgcgaga ggggtactat caccttgttt aacattacct
     4441 atacctatgt tgttagaagt ttcagatttt ctgagaacac tctctttttt atcttcaata
     4501 atacttttta gtagaggagt attttttgcg ttatacgtat tatcgaagtc ttgagcaatc
     4561 ccgacaagtg caagatcatt cttatttcta acaatagaat tgatgtaagc tttgcctttg
     4621 tttatccctt tattgacatg agcagcagct gttccacctt caaccacttt acctacttta
     4681 gaaagcttgg tagtggtttg cactgcggca cctgcacctt ttggcccaac gatatttcct
     4741 attgcataac tgatataatg tcctttttcg tatgcatcgc catttatcat tttatcattc
     4801 catgagtcga ccaggtttgt ccagatgatt tttgaataag agggcacgct taaaactgtt
     4861 gaaattgttt ttgtgagttt tagttcggta gggagctgtg aatattccca tgcgcctaca
     4921 accaagtctt tgacgccata tatcgtatcg tcaatcacat cgtcaattcc attattaact
     4981 ccatcgatga aatcaattgt tgccttaccg gcattgatca cactttcacc agcggtcttc
     5041 agctgtttta cttgttcaag ctgcaccaca tactggagct gttcatgggt aagattctca
     5101 tagccgactt ttttggcaat ttctaagtat tcatccggat ccgtcactcc atcagctagc
     5161 ttcctcttca attctttgat ttctcgttct ttagcttcat ctctcttgat ctttaaataa
     5221 gcttcagtct gtttctcgat atcgcctttt ctcttatgta tatcactttc tcgataagcc
     5281 ttggcattat aatggattgg tgtagcatta ttgcctttgc ctgtggattc ctcaagcttt
     5341 tggaagtcct tcttgatgaa ttgctcgttt ggctctgact gggcatattc agtaacaagt
     5401 gcttggtcca cgctgtctag tttattgact gtttttttgc gtttatcctc cgcatcagcg
     5461 agttcgtctt taaagtcttc agtcgagaac aaatcaagtg tgaggatgtc atcgatatca
     5521 tgtaagatat ctttcatcgc tttcttttgt tcagacatta tggcttttga ttttgtgtaa
     5581 gcattagcca gctcgtgttc taagaaggat tcttctatat atgcatcaga taagctggcg
     5641 tcctctaaag tgcctgaaat gcttgtcaag aaagcaattt tcatatcaag taagtcaatc
     5701 caattgtcag ctacacctgc gtgatcttgg taaaatgctt taatgttgtc ggcgcctttg
     5761 ccggaaaact cactgtcatc taaatcagct acggctttaa aggccttttt tagattgacc
     5821 atctgacttc ttaattcctt gtattccttt gcgcgtctat ctgcttctga aagcagtgat
     5881 ttggcttcaa atactttcat gatcatatcc tttcgtttga atagctccaa caagatttta
     5941 ccatgggaaa atgaagaaat atccagcgat gtgattcaaa agtgtgaaat gaataatttg
     6001 atctgtgtca atttacctat tcggattatt cgtttggaaa ctgatgacgc agtcagacgg
     6061 ttttgattaa tgaattaaag actgacggca tttatggacc aactacaaaa gcaaaacttg
     6121 aagcaaagtt gaaatgaaaa tgaaaagccc tttccttaga tggaaagagc tctttgcatt
     6181 tataaaaact attctgaatt tgaaaagtac aattctcata tccagatagg tcaaattgga
     6241 atcttgttgt atctatcttt tttgattttt caactttaat gttgaattgc cactctatag
     6301 agctacttcg cttcatatca tcacctccta taatcagggt atcacaaatc taaagtcatt
     6361 tggggagcgt gcgtctaagt acaaaattgc ataagttttt taacaaagaa gggatatttt
     6421 tttgttatac ctattgaccg ttgtaaatag gtattgtata attagagtat tgaaaggagg
     6481 tgctgaagtg gacgaggtga gaaactggat tcttgctatc gctggtatcg tgaccatcat
     6541 aaaacacatc tacgacatat ggcagaagga aagcgaaaag catagcaaga aaaagaaaaa
     6601 gcgctcccgc cgggtaagca agaagcgctg atacacagtg agcaaagggg agtaaatccc
     6661 cttgctcata ccattatatc acgtccacga taatatgaaa aaatatttta agcagtacag
     6721 cacagcagat tttgccgttt tgctcatttt ggttgctggt atcgttgcaa ttgatctgac
     6781 tgacgagggt atgtctggaa agattgcgca tactgtattg atgatagccg ttgttattac
     6841 cttgttaaaa ggattcatta tgatgtggag agaaagccga catgaaagaa agcgaaaaaa
     6901 ttaagtttat ccaggaagaa gttttgactg cagcggaagc gggggaattg cttggaatca
     6961 cccggcagcg tttaagtacc cttgtgactt ctgggaagct caatccggtt aagaaggttg
     7021 ggacagtagc attgtttttg cttggacatg tacaagccct taaaaaagaa ttagaagccg
     7081 gccggaagaa gtaccggccg tatgacaagt gaatgccttg acacaatatg tagagaaaaa
     7141 tggtgaaaat gatgtttttc tctatatatt gtgtttttaa gggttgtttc caaaaaagaa
     7201 atcaacgaaa tatcaatata tagtatctgc ttgttaaata atcaacattt ttatagcaaa
     7261 tatagtatta taactttttt tgtgctcaag agaaaaatat tgccaaatca tatgtttttg
     7321 cttaatatta gggtatacct tttatacgaa ggaggggttc ggatgaatat ttcagttgca
     7381 gctatgtact taataagtaa aagcgaaccg aatacaaagt atgaaattac cccaaaaaaa
     7441 ttacaaaaaa tcctttatta tgctcaggct tggcatttag ttaatgaggg aaaaacattg
     7501 tttgaaaatg aagattttca agcttggtca cacggacctg tacattatcc tacttacaac
     7561 gagtacaaat gttataggta ttcttcaata cctcctgttg agttttctga agagcttgat
     7621 ttgcatcctt tttctcaaaa agaaaagaat catctagatt caatctggaa agtttatggt
     7681 gagtatagtg ctgatgatct ggaacactta acgcatgaag aggatccttg gaaaataaca
     7741 agagggggtc ttgctccaga agcgccttca aatgaggtta ttccagaaga aataatttca
     7801 atgtactatg ccaaggtatc taacgatgta ttggctggca aatggaaatc acctttaaac
     7861 ccagcaccaa gattagaatg gctgattacc cctaaacgaa aaactgctgt aaacccttta
     7921 ttaaaatatg taggtacatg gagtggaaat gatttggatg agtgtatgga agaggtatac
     7981 aataatagag cagaggttca atttcattaa attatgttgc ttctagatac aaatcattgc
     8041 agtggtatta tcggggaaaa tccagacgtt aaagcagaac ttcaaaaatg tgactacgag
     8101 cgattgtgta ctagttttat atctgaagca gaaatgtact ttgcagctta caggtcagaa
     8161 agatgtatag aaaatctata caatgttgag gcatttttga gtgccatgat aatatataca
     8221 tgtgatgcta aaatttcgaa gacttatggt gaattaaaaa gtaaaatact ttttcacttc
     8281 ggtccaaacg agagaaacaa gagaagaaaa tacaccttac aaaaagcagg tataggtgaa
     8341 aatgaccttt ggatagcttc tgtagctatt gcacatgata tgactgtatt aagttgcgat
     8401 agggatttta aaagaattca agaggtggaa cccaacctta aagtggagag ttggataaaa
     8461 caaacaccta ttgtcagtga agaaactgtt acctcagatg tctaaaggta aacgttgttc
     8521 gtagaataaa tgagggaaaa caaaactcac ctacttggtg agttttttac attatccact
     8581 ttttctgcag tttatcccac ttcaattcac gtttcatcaa aaggcttttc acagctgcac
     8641 gaatatcctc ttcgttcttt cctgttttcc ttttcaaatc gttcaaagta ggattctttc
     8701 catacaaatg catattcact atgatctgat atactttccg ttcaaaatca gtcatttgat
     8761 catctcccta taggggatta tataagaacg aatgttccgc ctgcaaatat catgttattt
     8821 ttcgaaaaat aacacgaaaa taacgaaaat cccactcaat tgtgaaaaga tgcggtttct
     8881 tctaggttta tctttgttgt tttttatcac ggaatccctt gaatgaaaga gtctgaaatc
     8941 atgcgaaaat agggtgaatt atgggtggaa tgatgtaatc aaacggcgaa aacccttgat
     9001 ataccaaggg tttgaccgtt gacttcatct ggaaagcgcc aaatccctag attaggattt
     9061 ggcgcttttt tcttgtttga ctctctactt attcgattag aatactccca ttcgttttgt
     9121 taaagaagcc taatatctct aaaaaataaa ggtgagttgt tcttttagtt cgcgatattt
     9181 acttcgactt acatttatag tctttggaca gtctttaatt tttaaattgt aagatttcat
     9241 ataggtgtct tggataacct cttcaatttt gtccaatggg acaagaaatg actggtggct
     9301 tctaaaaaag ttgctgtctt ttaacatttc ctcaagaatg gtcaaccctt ggttacattc
     9361 aataatcctt ccattttcaa ggttgatgca tgattttctt ccgacttttt caatataaag
     9421 aatggattct atatctatga gatgaatttt accatttgag ctaatactga tctttttttt
     9481 cgcctacttt tatgattgtt cactaaactt actgtcgatt ttagtctcaa aaggttaaca
     9541 ggtttcacca taaaatccat tggataatac ttatatccat ctaacgcata atccggaaga
     9601 taactcatga aaataatact ggtgaagggg taatgaatat ttatatactc agccacatcg
     9661 aatccattat tttgaggcat attaacatca atgatgacta gatctacttc ttgcgtagat
     9721 tctagatgtg agattagatc acttatcttg ctagttatta gatcaaatct cgcttgactg
     9781 atctcatttg aaatcttctt aaagaaattt agtatctctt gatcatcgtc aataatctga
     9841 cggtcaatgt tcatcactct tttgattttg gggtaattcg ggttcataag caaaccagaa
     9901 acaactgctt gctgttgtaa gcgaattgaa aaacaaagcg gttaagccaa ttatataact
     9961 gatgcatttt aacatactcc ttactccttt aaccatttat ttaaaatctc ttatcaagtg
    10021 ataagaggat tttatcccat atgttagtca aagtgatgct ttgcaggata agtgccatcc
    10081 atatgccgta tttatgatgg tcatctccca taaggctgat taataggaga caagaaaaaa
    10141 tgccaattga accaattttg agctttttct tatgatcagg agtaaataaa tgtttctttt
    10201 tttgaagctt tggagaattt ttaaatgtga taaaaaatga aaagactaat aaaattttca
    10261 acacagactt agtccagaag gtgaaatgtg attcaaactc tattgatatg tatgttataa
    10321 acaagatttg cagggtgctg aagattaaac ataaattata gtttttaaaa tggcttcccc
    10381 cagatatcat tctaaataat ccaccactgg ctaaaacaat taaagcttgt gctaaataac
    10441 cgaaaaattc tgctaatata ataactataa atacttgatt gacagtagca agcatccatt
    10501 ctaaaccata gcgtatgtta tcttgcagtc ggcgaaactc agggttaaaa tgtataatat
    10561 gttttgatat ttttttcgcc agtttatgag gtgttagatc aaacatagtc tgcctccttt
    10621 ggtatcctga ctttgaaaat gatcattcga tcaatgattt ctgtaaaaat gaaaccatta
    10681 tatttctcaa caactgactt tacaatatga agaccataac ctctacctac tttgtctttc
    10741 gtggagaatc cttcttcaaa aatcctctcg ataacttctg aaaaccgttc aatatctcca
    10801 aaatttgaaa catcaattct atagtaattc tcagttgcat taatatgcac atatactgcc
    10861 cgtttcggga gttcatctat ttctttaaca gcatctagtg catttgtaat tagattgcct
    10921 aatattctgt ttgtttcaaa taatttgcac ggaaaacctc ttaaactatc actgattttg
    10981 tattgaatat gtatattttc ttttaaacct ttgtctttat aagaaagaag taatccacta
    11041 attgccactg aatgtaaagg aagaatatca cttatttgag cagaatcatt taacacatcg
    11101 ctgaggtact gataactttc tttggagtaa cctttttcaa gcatttgctt gatggtaata
    11161 agatgatgca tatggtcatg gttatgcctt tgaataaagt gaatgtactt acccacctct
    11221 tcatattgtt cctctaaata atcctctgcg tcccgaaggt tttgaagaaa gatacctcta
    11281 atcataaaaa aaataaacat ggtcaatgtt ataagtgcta ctccccaaaa taaattaatg
    11341 tattcgtcaa ctttcttatt tttatatata acgatgtagt agagaaacag tatggagaat
    11401 gaaagaattg aaattaataa taattgctta cgtaatctct tgcaggtgct aaaaatgtga
    11461 atcaggaaga acctctttct tcattcatac ccgggcccgg tacttgtctc acagcagcta
    11521 tttgcccaac taccgggatg tgcaacattt attaattgaa aggaggtgat attatgtcaa
    11581 atcgtgaaaa agcagaactc taccgtaatg ctagtaaacg tacagagctt ggattcgtta
    11641 acccagtagg tgaagtgagc gaggatgaat tgcgaaatct tgcaggtgca gccgatgtta
    11701 ctccgcatac cactccttcc tcactgcctt gcggagtatt tgtcacagca gctttttgtc
    11761 cttctaccaa atgtacatca agctgctaat cttaccaatg ataagtatgg ggaggattgg
    11821 tagggagctc aatccttctt cttacataac attgagacag atcacaaaaa acaaagagcg
    11881 gttggtcatg tttatgcgcg accagccgtt tctttatcta ttgtaatcgg ctttttagaa
    11941 tttatacata aaggaatgga gaggttttca tgattgaggc ttttaaacgt tctgcttacc
    12001 taaatgaacg agagacagtt cgcaaaacta caacactaga tcatataaaa gaattgagtg
    12061 aatggactaa tgcaattcca catgagatgc tcgagaagcg gctcgaaaag gatcatttga
    12121 ccagagagca actaatgttg cacatagaac agaaggattc accttttata aagaaggaat
    12181 taaagtggat tgagactttt gaagaactta tggatacata tgaaacttcc cctttagatt
    12241 acctcagttt tcagtcttta attcaccctt ttatcatata tgctaaaaaa caaattgaat
    12301 gtctttttaa aaaagtcacc agcaatttaa ttaatattga aacggtcact caatcgatta
    12361 cagatgccct ttatgcgcga cttcatatca tggtgatgaa gtgtgtaatt ctagaagtaa
    12421 atatagccag aaagatagag gtcttggaag gggatacaag tgaagagcgg tttcaatatt
    12481 ttatgcgtca attcaatgag gattctgaaa tgaggatgga gttttttgaa aactatccag
    12541 tactatctcg gttaatgact gagagcacga aaaactattt aattataacg gaagagctta
    12601 tagaacgttt tttatgtgat tatgaaaaaa ttaaagataa ttttgaaggt gaatttactc
    12661 gtcttgaaag gataaaaatg gatttaggag atactcatca aaatgggaga actgtagcaa
    12721 tattagagtt cgaatctggc gaaaaacttg tttataagcc tcggcaaatt ttgatataca
    12781 aatgttttga atcattactg gactggttga atgatagagg attgaagcat aagctcaaag
    12841 cagctaaaag tcttgattgt caaacatatg gatggcagga atttgttcct tttaaggaat
    12901 gtattctaaa agaggaaata cgtcggtttt attatcgaca aggggtatat acagccttgt
    12961 tttatgtatt gggttcctct gatttccatg ctgaaaatat tatagcaaat agtgaatacc
    13021 cagttcctat agatcttgaa actctcttta gtcagaatct tgaaatgacg aaaaaactaa
    13081 attttcaaag tcaattagct gttgaattaa acgattcagt cttttctact ctcatgcttc
    13141 cacttccgtc acttgaacat tcaattattg atttcgatct gagtgcgctt ggggcaatag
    13201 aaaaccaggt atcagaaaag ataaaaagca taaggataga aggagaggga acagatgaaa
    13261 ttagaataac gcgcgggcct gcaaaatcag ggcagtatca taatagacca gtgcttgaag
    13321 gtgaaacact ttcgccttcc gattatatca ctgaccttga ggagggattt acagacctgt
    13381 accgtctgtt tcttaaacat aaaaatgagt ttattagcga tgatgggcct ctacaaccat
    13441 ttggcaaagc ccatgtccgt caggtctttc gtccaactca tgtgtacagt gaatttttgc
    13501 aaaacagttt acatcctgat tatgttcaaa acggtcttga tcgagtgcaa ttgtttgata
    13561 ttctttggca aatttataaa caatcttcta agtttgaaga attggttatc tatgaaacaa
    13621 aggatctgct aagacatgat attccttatt tttattttaa gttaaacagt agagatctct
    13681 atgatagtaa tggaaatctt ataccaaact tctttacgga aacaggactt gaggctgttt
    13741 ttaaaaaggt cagccaactc aatagaattg accttgaaaa gcaaaaacaa tatgtgagat
    13801 ggtctcttgt atccatgtta ggggaagtat ggagattccc agaaaaagtg ttaacatttc
    13861 aagaaaggac ggaagaatct agtagttctt ttactcaaga agctcttgaa attggccgtc
    13921 tattagtgga tagagcaata actgaggaaa acatggaagt gaactggata ggattaaatt
    13981 tgaatgataa ggcaggactc agtgtatctg taaagggccc tgatttgtac gatggattaa
    14041 tcggatatgc aatgtttttg gcttacttat ccaaagaaac aaacaatcaa gaatacgaaa
    14101 aaatgagtcg aggtgcaatt caaactgtga tacgtaaagt tggtaacaaa ccacttaacg
    14161 aatctatttc ggcttttagc ggtgaaggag cacttattta cggactagtt catttagggt
    14221 tactttggaa tgatcaggaa ttaattaaac aagcaaaggt taggttacat tatgtttgtg
    14281 atatcgtaag aaaagaaaaa agccttgatt tttcaggggg acttgctggt tttattgtac
    14341 tttgcctaaa tatctttaac gaaattaggg attatgacta tttgaatgtg gctttgcaag
    14401 ctggagatca actgatgatt aagatggatg acactgccag aaaaccagga cttgcacatg
    14461 gaatagcagg atacgcttgg gcgcttggtt tgcttggtga agtatctcag gaagagaaat
    14521 accaaattga ggctcaaaaa ctgcttgtat atgaaaatac tttttatgat ggaagcacgg
    14581 gcaattggga agaaagtgaa tccaagaaaa aaagtgaacg aaaaagggtc tattggtgtc
    14641 atggggcgcc tggcattgct ctttcgcgga taatgttaaa agacattata aattctaaag
    14701 acattaaaga ggatattgac gtggccttaa agacgctgat ttcagaagga ggaatagaaa
    14761 gccattgtct atgccatggg acaatgggga atgtcgacat tctattgaca gctgccaaag
    14821 agttgaatga agaattgttt atgatacagg cattagaatt aaccaaaatt gcactggatc
    14881 agaaaaaggt gcatggttgg gttcatggct tggatcctcg tgcggaaatg gatggtttta
    14941 tgctagggag aacgggaatc ggatattgtc tgctcagatt gaaaaatccg agtattcctt
    15001 ctgtacttgc tttgcagtta ccaaaaggag aaaacttatg aagaagaggt ctccttttaa
    15061 aacacatagc cgcattccgt ttatagagca aatgcaacag acagaatgtg ccctttgttg
    15121 tatggctatg atagcgagtt actataaaaa tgatttgtcc atgtacgagc ttcgtgagcg
    15181 gctggggaac ggtcgcgatg gtacaacctt gttgcatttg aggaatatgg caaaacaatt
    15241 aaaattcgaa actaaaacct ataaagctga tactaaacaa ttaaggaatc tcgttttgcc
    15301 cgctatactt tactgggata acaaccattt cgttatcctt gaaaaaatca cctcacatgc
    15361 tttaattatc gttgatcctg gttctgggag aaagaaggtc aaggaaaagg attttacaga
    15421 aaaatattct ggatatgcgc ttactttgta tccaggtaat ggttttgagc aacggaaaag
    15481 aaaaaatatt tggacatctt tttctttttt agtaacgaat cggcctaaaa tcttcagcgc
    15541 cattctgttt cttacgtttc ttcttcaact gtttacagtg gcgatgcctg ttttaattca
    15601 gtttgtaatt gatcgcatta ttgtacctga ctacagggaa ctgcttaatg catttttgat
    15661 aggaatttgt ggaataatct tgttccattc cttattttct ttcatacgag gtaaaattct
    15721 cattaacctt cataatgtat tagattacga tatacagtca agatttttca aacacctact
    15781 caaactgcca tatcaattct ttttattgcg ctcctttgga gatttacttt ttagggcaaa
    15841 cagtatgaag gtgatacgtg atcagattgt caatcaggtt gttaaaggtc ttttagattc
    15901 tgctgtcata ctggtgatct tgctgtatat gcttatacaa tcgccattat tggctgttat
    15961 tgttttctta ataggcactt ctaatgtatt gctgattgcg cttagccaac gatacatttc
    16021 ggaagccaat cagatggaaa ttaaagggca caccgaagtt cagggagccc agacggaaat
    16081 gttatatggt attttcggag ttaagacatc tggtgtcgag aaaatgattt acgatagatg
    16141 gctttatcgt ttcaaaaatt tattgtgtgc atatcgtaaa aaggaaaatg tattaaatta
    16201 tgtaaataca gctagcagta cattacaatt aatggctcca cttatcattt tgtgggttgg
    16261 ggcacatcaa gtatttacag gaagtatcac actaggaatg ttggttgctt tccattcaat
    16321 ttcaacccaa ttttttatgc taagcggtaa tattgttcag accatcaatt ctttcatttt
    16381 gactacttct tatttaaaga gagttgggga tgttctcgac gctcccacag aatcaagaga
    16441 agacaagatg aagaagacgc taaatggtga tattcaattg aagaatgtca cttttgctta
    16501 ttctaaatat agtgaaaatg taataaataa tgtttccctc aatataaaaa aagggcagaa
    16561 agttgctctt gtaggacagt caggggcagg aaagacgaca atagccaaca tgattatcgg
    16621 gttgtttagt ccgactgatg gagaaatcta ttatgatggc attagtatta atgaacttga
    16681 tctgggccat cttcgccgtc aaattggtac agtgccgcaa aacgtaatgc tctttaatag
    16741 aagcatttat gataatatta ctctccataa tcctgaagcg acgccagagc aagtaattga
    16801 agctgcgaag gcagctcaaa ttcatgacga gattatgaat atgccaatgc agtatcatac
    16861 gatggtgtcg gagatgggga tgaacatatc gggtggacaa cggcaaagaa ttgctcttgc
    16921 gaaggccctt cttgggaagc catcaatttt agttttagat gaagcgacta gttcgttaga
    16981 tcacttgaat gagtcaaaaa ttgacgcgta tctgtcgggt ataaattgca ccagagtagt
    17041 aattgcgcat aggttaacaa cggtgatgaa ttgtgactta attgttgttg tagataaagg
    17101 aagaatcatt gaatcaggta gccatcatga attgttgcga atttcgagtt tctatagcca
    17161 attttataaa gaaatgattt cttgaaacgc ttcttgataa acaagaagcg ttttcggttt
    17221 gtaaagtaag ctttacaaat agtaaaataa acgttacaat ttaactgaaa tatctaatta
    17281 cggaggttga tcacaatgag tattgaagaa attgcgaaat acggaaatag tataggaggg
    17341 gtaattgttc tcctgtgtgt tgcaattatt tgggtagttt cgaagcagat gggaaaggat
    17401 gaacgttcaa acgcaatttt cctcagagtg tactgcttta tgttttatgt gctggccgga
    17461 cttattttac tgagtatttt ctttgaaatc ggtgaaggta tcagtggtca ggtgtaccaa
    17521 gagttgacag ttttaatgtt tgctctaagc acattgtttg gaaccatcta tctgttcatt
    17581 ttgaaaaaaa agttctgaat atgttttgtt tgtaaaacga tgggtcaaaa attcaggcaa
    17641 gggactggtt aaatttgggt agaaatcgat atattgtaga gacacatggt ttaacgaaaa
    17701 catatagagg aacagatgta gttaaatcgt tgaatttgaa acttcgtgag ggagaaattt
    17761 atggatttct tggtcccaat ggggcaggaa aaacgacgac aattcgtatg ttgctcggac
    17821 tcatcaatcc gtcaaaaggg gaaacgagaa tatttgggaa ggaattgaaa aataatcggc
    17881 ttgaaatttt acaaagtgtc ggttcacttg tggaatcgcc ctcctattat ccacatctca
    17941 caggcgagga aaatctagag actgtaagaa ggatattgaa tattcctaaa aaaaatataa
    18001 ctgatgttct cgaactggtt agattaacaa aaatggcaga caggaaagtc ggtgaatatt
    18061 cattagggat gaagcagcgc cttggaatag cggctgccct gcttggaaat ccaaagcttg
    18121 taattctcga tgagccaaca aatggacttg atccagctgg tattcttgaa atacggaaac
    18181 tgatcctcaa actgccgtct gaatatggca tcaccgttat gatctcctca catttgctat
    18241 cggagataga gcaggtagcc actcaagtag gtatcattgc caatggagag atgctgtttc
    18301 aggacgatat tgcaaccctg cgttcaaggg ctgatactaa gattgtattt tcgacaagtg
    18361 actcggataa ggcgttgaaa gtatttttaa aagaaggagt agaggcaatc aaaacacagc
    18421 atggtctaat gattgaagaa agaacggata aggaaatttc agaacttgct aaaaaacttg
    18481 ttcataatga gatagatatc tttcgaatat ctgacgaagc gaagtcactt gaagatattt
    18541 ttcttgaaat gacaagaggg ggagagacct tgtgatcgct aaattgctaa aatcagaaat
    18601 actgaaaatt aggaatctga catggctcat agtcatctta ggccctcttg gagtagttgt
    18661 gatgcaagca gccaattaca cgatgcgatt tgattatctt atgtctaaaa gctctgataa
    18721 atggatgttt ctattagaaa atattcattc ttactggccc tcagcactcc tattagagat
    18781 tacaattgta aactctcttt tggcaggtat agaacaccat ggtgggatgt ggaagaagat
    18841 cttttcgctt cctgtttcac attggaaagt atatcagtct aaggtaatta taattgttac
    18901 catgttgata atatcgacag taatacttgc aggagggacc tttctgcttg gaaagttgat
    18961 cgggtttcac gaaacttttc catttgggag tacactgaaa atgagctttt atacatttat
    19021 tgccgctctt ccttttgtat ttatgcagtt ttggctgtcc ataaattacc ggaaccaagg
    19081 gattgcttta acaattggta ttgcaagtgc cgtgtttatc atgtatgctc agggattgcc
    19141 tgattggatg ccatggaaat ggccaatgtt aatagagggg attggagaaa gtatcctttc
    19201 agtaattaaa ggtttggtct tcgggctgtt tttatactca attattatgg tatctctgtc
    19261 acgaaaggat gtggcttaat ttgttctttc aattattaga cacagagtgg ctgaagttaa
    19321 aacattcgaa gatctggttt attgtgctag ctagtcctgt tctagctgca attattggtt
    19381 tttttccggt ttttaaaatt ggaacaaatg aatggctcac actttgcact caaatgatcc
    19441 tagcacacag tgcgttgttt ttacccttat tgacgggtgt tcttgctgca ctgatatgta
    19501 gtaacgagca tgcctatgga gggtggaagc agttgttagc acttccggta aagcgtattc
    19561 aagtatattt ggctaaatat gtaatagtta tgttcatgct tttgtggact cagatctttt
    19621 tcattatcag tgtttggttt gtcggaacag taaaaggatt tagttcgccg tttccttgga
    19681 atggtgttat tatgagcgct cttatgggat gggtgtcatg ctttccatta gctgctcttc
    19741 aattttggtt ggcaacatat tttaggagtt ttgcgggtcc tagtactgtc aatgtaatgt
    19801 taacattgcc ggccattatc attgctaatt caaagtttat gggtccgctt tatccatggg
    19861 ctcatccaat gctcagcatg acacaggcat tctcggctgc cataggaggg aatgcgggct
    19921 ttttagaaaa tgaacctact ttttatgtaa cgctgatcgt aagtttcatt ttatttttct
    19981 tcggcggagc tttatatttc cataagaagc aatggacata gttatgcaaa caatggagga
    20041 ttgttatgca aaaaaataaa caatcgaaaa agttgacgaa tcgactccct gagtggcggg
    20101 cacgtactaa gttgacgcag cagcaactag cggagaaaac tggggttagt agacaaacga
    20161 ttatctcaat agaaaaaatg aaatacaccc cttcactagc actcgcattc gaaattgccc
    20221 aagcacttag ttgttcgata gatgacgtgt tccaatataa tgaggaaaat gaatagaaaa
    20281 ttagaaagga gagaatattt ttgattattg aaacgaaagg tgtgacaaag agttacaatc
    20341 gcgttgatgt cgtacatgaa gttgatatga tggtacctga aggtgaaata tatgggttcc
    20401 ttggaccgaa tggttctgga aagacgacga tgatgcggat gctgcttggc ttggttcgac
    20461 cgaatagagg ggttatccgt atgtttggaa aaaagatgcc tgaagatcga atttccatat
    20521 tagccaaaac aggtgcctta attgagaagc ctgcctacta tgaacatctg gatggacgag
    20581 ataatttaag ggtattagca gcactgcgcg gtatcaatga taataaaaca attgatcggg
    20641 cgctagagag ggttaacctc catagagtcg ggagaaaaaa agtcaaatca tattcgcttg
    20701 gcatgaagca gcggcttggt attgcaagcg ccatgttgca taatcctagg attcttctac
    20761 ttgatgaacc aacgaatggt ttagatccag aaggaatatt tgagattcgt gaactaattc
    20821 gaaatttgtc tgaaaaagaa ggagttactg ttcttatatc tagccatctg cttggagaga
    20881 ttgagcatgc tgctagtcgg atagggatca tttacaatgg aaatctattg taccaaggaa
    20941 aaatgaatga actgcttaca catcaaaaaa tgggttcttt tattatcgag tcaaacatga
    21001 tcgagctaat catcaatgct ctgcaagcat atgatattca aactagttta gacggtgaag
    21061 ggaaggtgca agtgcgggga tcagaagcag atagagatag aataaaaaaa atcttggtag
    21121 agaagggatt aaccgatttc catatatatg attcgatgag gactctggaa gaagcctact
    21181 tagaattaat ccgttcacaa aaggtgtcag tatgaaaaac atcattaaag ctgagtggcg
    21241 gaaaaagaga tctactgttt ttctaatacc attgttagtc ggatcattac tgatttttgc
    21301 aatctgcggt tctataatgc tttccttgac aaaaaacgga caatcaattg atcgagcatt
    21361 tgaggtgctt tatgagcttt gtgtaacaaa ttggaactat cttgtcattc ttgttgtcat
    21421 tacattctca ttgcttgcta ctgaaatgga gcatagattg ggtatgtggc cgactttgct
    21481 tactacgcca cattcaaagt ggaaacactt ttttgtgaaa gtaattactg cggttgggtt
    21541 tatacagcta tttggactat gtgtttgtct ttatttaagc ggtttgggct tcttatacgg
    21601 aaagtctttt tttgaatata taaaaatatc tttggaatta ttatatttgc cctttcttct
    21661 tgcaatccca tttgtaatca cccagacgct tatatcgatt ataatagtaa atccttatat
    21721 ctctgtaggt atcggcatgg cggttttcct ttttcatgct atgctgcctt attggtggct
    21781 tccttgggga gcacttgctt acatgcaatc caataccaga ataatagaag tttttccgtt
    21841 actcatttcg ttgtcattgg gatatggtgt attatccatt tttgtttttt gccgaaaaat
    21901 gttttcttct gggggggagt gaattggtag gtttccaaca ggtttttttt gcggagtgga
    21961 ttaaaatcaa aaaaaagaaa agtttgcttc tcattattat tttggttgca cttccagtta
    22021 tatacggatg gattattcat acaaaagtca tgattgaaac atatggttat gacgaaggga
    22081 attcctggaa ggtgctaatc atgatgactc aaatgtttta tggaacagtt ttctttccga
    22141 ttattatttc tcttgtaacg ggaactctaa ctggatatga acagcgagct aatagttggg
    22201 agcatttgct gatgactccc gtaaaagggg tactattctt tttcagcaaa atggcttggg
    22261 ctggcattat cattctgtct acacaattgc ttatgatagg gttactgatc gttcttggct
    22321 atacagcagg ctatacagat aagttaccaa tggatatatt cttattcaca gtactttttg
    22381 gaactgtggg aggaataagc cttgggacac ttttatttta tttttattta cgaatgaaat
    22441 ctatcagaca gtcactgttg atcagtattt ttttgagttt tccttctttt ctggcatttt
    22501 cgaatagttc gggatcctgg attcctatgt tatatccatg ggctcttcct ctttatggaa
    22561 tgacgaatgt atacgctgat tgggggaggg tgggtatatt tatcattgtt tgcgtaacaa
    22621 tgaccattgt tttctcactt cttagtgtta ggttactgaa tcgaaaagtt atagacttga
    22681 aaaattgaaa aaaaatctaa gatgatgaat agcttactga acctctagga aattttcaca
    22741 tcatgaagag atgaatagta ggcttcgggg ggaatattcg cattgaaccg agtttatatt
    22801 ttaatgttac tgcttctagg atgtgtctta gttataccac atcatgcttt agctgaggac
    22861 aatcgactga acacatacac ggttttttta aagagtccca cttatgaaaa aaactggatc
    22921 aaagcacttg agagaaaggg gataaaactt gaatacgacg tcgaagaaat aggtctgtat
    22981 gaggtgaaag cggaacgtga aaaatttgag gctttgatgg ctgatataaa ttatgtagat
    23041 agttacaatg aagctgtttc aataaagccg gctgagctca ctaggattag caaagagaac
    23101 tttacggacc aagatgaaga taattctttg tgggaatatc agtgggatat gaaaaaggca
    23161 acaaataatg gcagaacata tgaaattact aaagggagta agaaaacggt tgttggcata
    23221 attgactctg gcattgataa gaaccatctc gatttaaaag ataatgttct ttcggtcagc
    23281 aattttgtgc cgaaaggagg attaagagga caggaaccat atgaaaatgg tgagattaat
    23341 aactctacag attatctggg acatggaaca tttgtagccg gacaaatagc tgctaatgga
    23401 cagatgaaag gaatcgcacc ggaaacaggg atcagatcat atagagtatt tggtggaaaa
    23461 agcgctgata cagtttggat tattaatgct atcattcagg ctgcaaagga tgacgttgat
    23521 gttatcaata tcagtctagg tactttcctt gttaatagta aaggaaaaaa taatggaaaa
    23581 ccagttacgg atgatttggc tgaaatcaaa gctttcagaa aagcggtggc ttttgctcat
    23641 agaaagggaa gtgctgtagt agcttcgata ggtaatgaag gacttaattt aaaggataaa
    23701 aaagctgtat atgattattg gaaaaataac ataaatcaag aagggcgttt tatgaatgcc
    23761 aaagtaattt taattccagc tcaactccca aatgtagtga ctgtagcctc tgttggtcca
    23821 aatggaaaca gatcggtttt ttctaactat ggtaaaaata ttgctgatat tgctgctgat
    23881 ggaggggatc atcgtatttt gaatgaagtt ggagccgaga agtattatca agaaggactg
    23941 tttagacaag aatatatcct aggagcggct ccgggaagct catacacttt ttcggtaggg
    24001 acttcgatag cagccccgaa aatctctggc gctttggctc ttttaatcga ccagcgctat
    24061 ttacatgata aaccagataa aggaattcga attttactta aaaacgctga taaatacgat
    24121 tccaatgact atattggtaa gggtgtattg aatatttata aggcattaat tgattagatg
    24181 ttaacattag aaatgtaata ggatatcatt aataagctaa taaatctgta attaggtaac
    24241 aatcaaactt ttaattatac aagagtttga ttgttacttt ggtcctttgt atagtatcca
    24301 agatgaaatt acgctctaca ctgcctgtcg aaaaataggc tacacgtata agaggaatag
    24361 tactagcccg tgttaaactc acttatacaa tctattacat tataggtaat ttatatcaat
    24421 tttttaaatc gctccacctc acctcgaatc ccaatccccg gctcccacga atcaatcaga
    24481 cgaattgctt tctgattcga ttctatcgct ttcgttttct ctccttttcg gtacaacagc
    24541 tgtgccattc cgtagtgata gtagatcagt tcaacttgat tggcgttgtg tttgtcatag
    24601 agcatttgtt caaaggcttt ttccgctttt tcgagttgat cacactttac gtaagccatg
    24661 cccaggttga aataggcttc tattgttttt tcgccgccgt atgcggcgct ggttgtgttt
    24721 gccgcttcgt ataatgtgat ggcttcttcg tagtgagagc gggcgaaact caggtcgccg
    24781 cggaccagaa gaaccctgtg ccggataatg ggggagacgg gctgatcttt gatgccgtcc
    24841 agcattgctg ccgctttttc cggttctccg atttttaaca gcagcctcga ttgcagggcg
    24901 gttccccata ctttcaagtc gtcgtgatcc ggcgcgtctg atagttcgag tatcttcagg
    24961 ccggcttcta tttgtctgag agctccgtct gaatcgttga cttccatcag cgcccagcct
    25021 gccgtgtcga tcctgaagta g
//
