LOCUS       gnlProkkaAPCKLLDC_36   14279 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|APCKLLDC_36.
ACCESSION   gnlProkkaAPCKLLDC_36
VERSION     gnlProkkaAPCKLLDC_36
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 19:09:37
            Original ID  :: gnl|Prokka|APCKLLDC_36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14279
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14279
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2667:4279]"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2668..4279
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    1..14279
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14279
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="sactipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     CDS             123..296
                     /locus_tag="ctg36_1"
                     /transl_table=11
                     /translation="MGALFLHLKPDEYLKKLYKTKKLVEKTSFSLQAKDKARRLCPFDR
                     DYIFSGADTPIS"
     CDS             complement(260..1930)
                     /locus_tag="ctg36_2"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLEFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALRE
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     CDS             complement(1927..2355)
                     /locus_tag="ctg36_3"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     CDS             2668..2799
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_functions="biosynthetic-additional (sactipeptides)
                     predicted sactipeptide"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_4"
                     /sec_met_domain="Subtilosin_A (E-value: 2e-30, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       2668..2697
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="ctg36_4_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       2698..2799
                     /prepeptide="core"
                     /locus_tag="ctg36_4_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="33.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[2667:2697](+)"
     CDS             2933..4279
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_5"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1081.0, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 1.2e-30,
                     bitscore: 98.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.5e-09, bitscore: 28.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.4e-23, bitscore: 75.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-11, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.7e-11, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLN
                     KTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRASR
                     HTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADMLFDN
                     GVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQKIIVG
                     ISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKV
                     RDLGAKAFSYNWVDDFGRGRDIAHPTKDAEQHRKFMEYEQNVIDEFKDLIPIIPYERKR
                     AANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRF
                     SEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI"
     CDS             4292..4453
                     /locus_tag="ctg36_6"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGI
                     RARKADSR"
     CDS             4450..5169
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 127.7; E-value:
                     9.5e-39)"
                     /gene_kind="transport"
                     /locus_tag="ctg36_7"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     CDS             5162..6472
                     /locus_tag="ctg36_8"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNAYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     LMFLLHAAIFACVCISAALMPAATLPLCAVHMLWAVIIDFPVFLQAPPQQSKMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAAFSGFFSFQMMNTGIFNQQVVYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFISGRPIS
                     VLTFLQCIELLLAGAFIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPLFLATLAG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     CDS             6438..7622
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_9"
                     /sec_met_domain="Peptidase_M16_C (E-value: 1.3e-06,
                     bitscore: 21.2, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQAKENGLEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYF
                     YGAAAYLKEQIIDAFGCAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALLKT
                     FADLSFPSSLSFEAVEKARNELLLRIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRK
                     DRIKAIHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSERIPVNRH
                     VFETETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAV
                     YHVITRYDVMNNLLLVSICTDQLHEIDIPPRVLEAVSAFHTDERELEQAKQFLRNELLL
                     QFDSPEGLLAYMGILRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     CDS             7627..8907
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_10"
                     /sec_met_domain="Peptidase_M16 (E-value: 2e-14, bitscore:
                     46.4, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNDQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQTHRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYHAERKIIPACPPALSQKMMLGDEERMEDTWTGLQIGALPGQNDLWVIKLYWDIA
                     ARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHIIQDMDAQ
                     VFLSLIDAMASSNKAIIHVSQKEAIRQ"
     CDS             8904..9605
                     /locus_tag="ctg36_11"
                     /transl_table=11
                     /translation="MKKSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPALSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSFIYKR
                     FSYRSTASLDL"
     CDS             complement(9611..10987)
                     /locus_tag="ctg36_12"
                     /transl_table=11
                     /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDIPKGFKVDSAEAS
                     AAVTWSTDNVSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGNGA
                     VSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVTGTLVLPPSPDPQ
                     SYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLVSVID
                     NKTLTIINTITVGGGPRKIEFDPKDEFAYVMAAGSIYVINTASQSVIDVIPIPGALDFA
                     LDPNGQYVYTANGSSWSVDKYDINTGQLVESIIDTFEFPSLIATPYAGNFAYVLNGELW
                     PKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTAR
                     QRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVGAGPSAIAM
                     "
     CDS             complement(11026..11511)
                     /locus_tag="ctg36_13"
                     /transl_table=11
                     /translation="MFAYVLNFGLVQKVDLSTGEVTGTIERELIVSSIETDSPERYAYV
                     LEQEFLFNYLTVIDLNTFTISNTQELEPDGQYRMFTSGTGVYLYDDFTGNLYSVSPNGA
                     GVIGNLPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAITI"
     CDS             complement(11544..12377)
                     /locus_tag="ctg36_14"
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISDITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANPNDQSVSVIDTNTHTVVTTIALPYNPAGIEITPDKSAVFVLHPNNNV
                     ISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAIYVIGIDTLTVERSI"
     CDS             12607..13752
                     /locus_tag="ctg36_15"
                     /transl_table=11
                     /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFSMDY
                     ARQAYEIYKENEAYNIRLLQCHSLFATNFLDLKQYEDAVSHFQKAYSMAEAEKQPQLMG
                     RTLYNIGLCKNSQSQYEDAITYFKRAIAVFEESNILPSLPQAYFLITQIHYKLGKMDKA
                     HEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYADLEDFT
                     IDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV"
     CDS             13736..13855
                     /locus_tag="ctg36_16"
                     /transl_table=11
                     /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI"
     CDS             13953..14264
                     /locus_tag="ctg36_17"
                     /transl_table=11
                     /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIAK
                     SLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPIG"
ORIGIN
        1 gcatgggctt cgctattgca ggttgagggg aaaacgaaat gtgagtgaac aagttctcct
       61 cacagccgca tgccagaaca tgaagaaaat tgccacatac ctagccaagc agggctaggc
      121 atgtgggagc gctttttctg catctgaaac ctgatgaata tctaaagaaa ctgtataaaa
      181 caaaaaagct tgtagaaaaa acgtcgtttt ctctacaagc taaggacaaa gcccgaagac
      241 tttgtccttt tgatcgtgat tacatttttt ccggagccga tacgccgatc agctgaagcg
      301 cattgttcag cgtaatttgc gttgccttca ttaaagccag gcgcgcacgg cttttctctt
      361 cattttcagg gtcgatgact ttctctgcgt tgtagaagct gtgcagagca gaggccagat
      421 cataaatata gtttgtgaca cggtgcggaa ttcgtttttc cgctgcttcc gccactgcct
      481 ctgggaagcc gccgatcgtt ttcagcagat cgtattcttt ttctgattga atatggctga
      541 aatcaagatc cgccgccggt ttaagtccct gctcttcccc ttggcgaagc atgctgcaga
      601 ttcgggcatg tgcatattgt gcataataca cagggttttc gttagatgtt gatacagcaa
      661 gatctaagtc aaaatccata tgggtgtccg cacttcgcat cgcaaagaag taacgaacgg
      721 catccaagcc gacttcttca atcaggtcac gcatcgttac ggctttaccg gtccgtttgc
      781 tcattttcat tttctcgccg tttttgtaaa ggtgaacgag ctgaatgatt tctacttcaa
      841 gcgttccttt ttcatagccc agcgcttcga ttgccgcttt catacgcggg atgtagccgt
      901 ggtgatcggc gccccaaacg ttgatcagct tatcaaagcc gcggtcaagc ttgtccttat
      961 gatacgcgat atcaggaaga aggtacgtgt acgtgccgtc cttcttgatc aatacgcggt
     1021 ctttatcatc gccgaaagtc gtggaacgga accaagtcgc gccgtcttct tcatagacat
     1081 ggcctttttc gcggagcgct tcaagcgcct tgtcaatttt tccattttgg tacagtgaag
     1141 tttctgaata ccacacatca aacggcacac ggaagttttc caagtccttg cgcagctttt
     1201 ccagctcgta tttcaggccg tattcacgga aaaactcgag gcgttcactt tcctcttcgt
     1261 taacgaaacg atcaccgtat tcctcagcga gacgctttcc gatcgcaatg atatcctcgc
     1321 cgcggtagcc atcctccggc atcggttttt ccaatccgag tgcttcaaag taacggactt
     1381 caacagaaag cgccagattg ttgatttggt ttcccgcatc gttaatgtag tattcgcggc
     1441 ttacatcgta acccgctttt gaaagcacgt tgcacaagga atcgccgaca gccgccccgc
     1501 gcgcatgccc gaggtgaagg tctcccgtcg gattcgctga tacgaattct acctgaactc
     1561 gttcaccgtt tccgatgttt gtttccccgt atgcttcccc cgcttccagt acagacggaa
     1621 tcagctttgt taaatattga ttgttcatat agaaattgat aaaacccggg ccggcgatat
     1681 ccagtttttc aatcgaagcc tttcctttat caaaatgagc gacaatctct tcagcgattt
     1741 gacgcggcgc tttttttgcc actcttgcca gctgcatcgc catattcgtt gagtagtcgc
     1801 cgtgtgtttt atctttcggt gtttctaaaa caacattggg aatctggctt tcttcagcca
     1861 gtcccgcttt cagaacggcc gctttgattt cttctttcag cacgtccttc atttgttccg
     1921 caatgttcat gcgtgagttc ctccctcata cgtgatcgtc atattatgta aatgctcctg
     1981 ctcgtctccg acatgcatgt catatgcgat gctgatacgg cctttttctt catcgagatc
     2041 agattgaatc gattttgtgc ttgttttcag ctcaagctca ccaaatgaca ttttatattt
     2101 agcaattgtg gaagctcccg ttacgaaacg ctgattcatt ttgacagcgc ctgacctcat
     2161 gaccaggact tcgccttcgc ttactttcac aatcgttttg actttgccta agtcgtgttc
     2221 ttcataataa gatagataca ctttattttg ttttacatag taaaatccgg tggtgcggaa
     2281 ttcgatgact tcttggtttc cgtcatcctc gatcacagac ttcacatgga gtgttatcgg
     2341 tgtctcttgc ttcattctga cacgtccttt tcatcattcc actttgactt gaatagtata
     2401 atcattcggt ttgtaaactt caactgcttc tatcttacca tcattgctca tcagatttga
     2461 agataaacct cataaaaagc atttccttat atagaagaga aaatcatatc actaattacc
     2521 tttaggaaat gttacatttt tccgaaatct atcatttcct tttcacattt ttttcaaaat
     2581 atatgcattg aattagtaat ttgatagttt taagataaaa gtacaacata gatctgctag
     2641 aaaaacaaaa aaagggagga ttcaattatg aaaaaagctg tcattgtaga aaacaaaggt
     2701 tgtgcaacat gctcgatcgg agccgcttgt ctagtggacg gtcctatccc tgattttgaa
     2761 attgccggtg caacaggtct attcggtcta tgggggtaag gatctcccaa aagggcatag
     2821 tcattctact atgccctttt taagtaaatt acaattttta actaaaatct acctcttgga
     2881 tatacataca caaccgtttt tcatttgaat catatgtata ggggatggta ttttgtttat
     2941 agagcagatg tttccattta ttaatgaaag tgtaagagtt caccagcttc ctgagggcgg
     3001 cgtgttagaa atcgactact tgcgcgataa tgtctccatt tctgactttg agtatttgga
     3061 tctcaacaaa acggcttacg agctctgcat gcgcatggat ggccaaaaaa cagctgagca
     3121 gattttagct gagcaatgtg cagtgtatga tgaatcaccg gaagaccata aagattggta
     3181 ttacgacatg cttaacatgc tccagaacaa gcaggtgatc cagcttggaa accgggccag
     3241 ccgccataca atcaccacga gcggcagcaa tgaatttccg atgcccctgc acgccacctt
     3301 tgaactgacg caccgctgta atttgaaatg cgcccactgt tatttggaaa gctcacctga
     3361 agcgctcggc accgtgtcga ttgagcaatt caaaaaaacg gctgatatgc tgtttgataa
     3421 cggtgtattg acatgcgaaa tcacaggcgg agaaattttt gtccatccaa acgccaatga
     3481 gattcttgac tatgtgtgta aaaagttcaa aaaagtcgct gtcttaacaa acggaacact
     3541 catgcgaaaa gagagcctgg agcttttgaa gacttacaag caaaaaatca tcgtcggcat
     3601 ttctcttgat agtgtcaatt ccgaggtcca tgactccttt agagggagaa aaggctcttt
     3661 tgcccaaact tgtaaaacga taaaattgtt gagtgaccac ggtatatttg tcagagtcgc
     3721 catgtctgtc ttcgaaaaaa acatgtggga aatccacgat atggcccaaa aggttcggga
     3781 tctcggggcg aaggcatttt cttacaattg ggttgacgat ttcggaagag gcagggatat
     3841 tgcccatcca acgaaagacg ccgagcagca ccgcaagttt atggaatacg agcaaaatgt
     3901 gattgatgag tttaaagatc tgattccgat tattccctat gagagaaaac gcgcggcaaa
     3961 ttgcggcgct ggctggaagt ccattgtgat cagcccgttc ggcgaagtac gtccttgcgc
     4021 cctctttcca aaggaatttt cattgggaaa tatttttcat gattcctatg aaagcatctt
     4081 taactcccct ctcgtccata aactgtggca agcgcaggcg ccgcggttca gtgaacattg
     4141 catgaaagac aaatgcccgt tcagcggcta ttgcggaggc tgttacttaa aagggctgaa
     4201 ctctaacaaa tatcaccgaa aaaacatttg ctcttgggcg aaaaatgaac aattagaaga
     4261 cgtggtccag cttatttagg agggaaacga tttgtcacca gcacaaagaa gaattttact
     4321 gtatatcctt tcatttatct ttgtcatcgg cgcagtcgtc tattttgtca aaagcgacta
     4381 tctgtttacg ctgattttca ttgccattgc cattctgttc gggattcgcg cgcggaaggc
     4441 tgactcgcga tgagcatttt ggatatacac gatgtatccg tttggtatga acgggacaac
     4501 gtcatcttag aacaagtgga tttacattta gaaaaaggcg ccgtttacgg gttgcttggg
     4561 gtaaacggcg ccggaaaaac gacactgatt aatacgctga caggcgtgaa ccgcaatttc
     4621 agcgggcgct ttacactgtg cggaattgaa gcggaggccg gcatgccgca gaaaacatca
     4681 gatcagctga agactcaccg ttacttcgcc gccgattatc cgctgctatt tacagaaatt
     4741 acggcgaagg actatgtgtc tttcgtccat tcgctttatc aaaaggattt ttcagagcag
     4801 cagtttgcca gtttggccga ggcctttcat ttttcgaaat acatcaacag gagaatttcg
     4861 gagctttcct tggggaacag gcaaaaggtt gtattgatga caggcttatt gctgcgcgct
     4921 cccctgttta ttttggatga gccgctcgtc ggtttggatg tggaatcgat agaggttttt
     4981 tatcagaaaa tgcgcgagta ctgtgaagca ggcgggacca ttttgttttc ttctcatctg
     5041 ctcgatgtcg tgcaaagatt ttgtgattat gcggctattc ttcacaacaa acagatccaa
     5101 aaggtcattc cgattggaga ggagaccgat ctgcggcggg aatttttcga ggtgatcggc
     5161 catgaataac ataatcccca tcatgtcttt gctgttcaaa cagctttaca gccggcaagg
     5221 gaaaaaggac gccatccgca ttgccgcagg ccttgtcatt ctggccgtgt ttgaaatcgg
     5281 gctgattcgc caggccggca ttgatgaatc ggtgttgcgc aaaacgtata tcatactcgc
     5341 gcttctctta atgaacgcat atatggtgtt tctttctgtg acatctcaat ggaaggaatc
     5401 ttatatgaaa ctgagctgcc tgctgccgat ttcttcacgg agcttttggc tcgcccagag
     5461 tgtcgttttg tttgtcgata cctgtttgag aagaacttta ttctttttta ttttaccgct
     5521 gttcttattt ggaaacggaa cgctgtcagg ggcgcaaaca ttgttttggc tcggcaggtt
     5581 ttcgtttttt accgtttact ccattatttt cggagttgtg ctaagcaacc acttcgtcaa
     5641 aaagaagaac ttgatgtttc tgctgcatgc ggcgatattc gcctgtgtat gtatcagcgc
     5701 cgctttgatg ccggccgcca cgcttccgct ttgcgcggtg catatgctgt gggcggtgat
     5761 cattgacttt cctgtctttc tgcaggcgcc tccgcagcag agcaagatgc attcatttat
     5821 gcggcgatct gaattttcgt tttacaaaag agaatggaac cgatttatct cttctaaagc
     5881 gatgctgtta aattacgcgg taatggcggc gttcagcggc ttcttttcgt tccagatgat
     5941 gaataccggc atcttcaatc agcaagtggt ttatatcgtg atttccgcgc ttttgctcat
     6001 ctgctcgccg atcgcccttt tgtattcgat tgaaaaaaat gaccggatgc tgcttatcac
     6061 gcttccgatc aagcggaaaa cgatgttttg ggcgaaatat cgcttttatt caggcctatt
     6121 ggcaggcgga tttctccttg tcgtgatgat tgtgggtttc atcagcggcc gtccgatttc
     6181 agttctcact tttttgcagt gcattgagtt gctgctggcg ggagctttta tcaggttaac
     6241 tgcggatgaa aaaaggccct ccttcagctg gcagacggag cagcagctat ggagcggttt
     6301 ctcaaaatat cggtcttatc tgttttgtct tcccctattc ttagccacat tagccggcac
     6361 cgctgtatcc ttggcggtca ttccgatagc cggtctggtc atagtctatt acctgcaaaa
     6421 acaggatggt ggtttctttg atacaagcaa aagagaacgg cttggaagtt aacctgctga
     6481 agactcatca attttcaact atttcaatcg ccgcgagctt tctgaaaccg atcgaaagcg
     6541 cggcggaacc tgaggaagaa acgatttatt tttacggcgc cgccgcatac ctgaaggagc
     6601 aaattattga cgctttcggt tgtgctgccg gcagccgttt catgtactca gcgaatctct
     6661 tttttgatca gcagctgaaa acctgcggga cccgtttgat tcacccatta tataacggga
     6721 atcttcatgt tgacgccctg ctgaaaactt ttgcagactt gtctttccct tcttctcttt
     6781 cattcgaagc agttgaaaag gccaggaatg agctgctgct gagaatcgaa aagaaattca
     6841 ctgatccttt ctcctactcg gcggcgcgct tggctgagga ggtcttcgga aacccgatgt
     6901 acggcacagg catgtttggc cggaaagaca ggataaaggc gattcatcct aaacggtttc
     6961 tcgacgcaac ggactttatc gttgatttag tgtcccagca aaaacagctg aacatattgg
     7021 gacaagtaca agcatgtgat gttcggggac atgccccgca aacgtccgct gtaacgtccg
     7081 aaagaatacc cgtaaaccgg catgtttttg aaacagagac acgcagcgct gcaggtcctt
     7141 ccgtcttgac actcggattt gactgcggag agatgaaaga tgccagcgat tatatcaaaa
     7201 tacagctaat agacggatta ctgggaaagt acggccattc cgctttattc aagcacttca
     7261 gagagaagga tctggcagtc tatcacgtta tcacccgtta cgatgtcatg aacaatttgc
     7321 tgcttgtttc aatatgtaca gatcagcttc atgagataga cattcccccg cgcgttttgg
     7381 aagctgtctc agcttttcat acagatgagc gggaactaga acaggcaaag cagtttttac
     7441 gcaatgaatt gctgctgcaa ttcgattctc ccgaaggtct attggcctat atggggatcc
     7501 tgcgccgctt ctcctgcacg aaagaagcct tgctggatgg catctcagcg gttacatgcc
     7561 gtgatgtatt gcaattcata gcgaccatca attatatcgg agctcatgta gtaaggggat
     7621 gaagagatgg aaaataaagc cttttttcaa cagctggatg aacgaaccga tatcagatac
     7681 acagacagcg gactaaaaat attcagattg aaattccccc gcgcccacct gcggctgtgc
     7741 aatgtaaaaa tcgattttgg aagccgggat gtatgtatac gggcagaatc cggtgataca
     7801 ctgcttccgt atggcacagc gcatttttta gagcatcttc tcttctggca taacggccgc
     7861 aatctgtaca gtgatttttt tgcgcatggc gcgcttttaa acgcattcac tacctacacc
     7921 gataccaatt tcatgtttac ctcattaccg gatcggctca gacaaacgat ccccatcctg
     7981 cttgatgctt tatggaacca ctcatttgac aagaagattg tcgctcagga aaaagctgtg
     8041 attacaagcg aaattcaaac agcacacctt aacgatcagc tctcatatca ttatcagctg
     8101 atcagcatgc tttctccctc ctcaccagct gccgttttcc ccgcaggcag aatcgaagat
     8161 attgaggcgc tggacatcag tgatttacaa aaagcctata aggctgccta ccaaacccat
     8221 cggatgacgc tgtttttgat tgggggctca gaaaatacag aaacgctttt gcctcctcac
     8281 ctccagctgg aaaagcgtcc ggattatcat gctgaaagaa aaatcatccc ggcatgccct
     8341 ccagccctct cacaaaaaat gatgctgggt gatgaggagc ggatggaaga tacatggacc
     8401 ggattacaga tcggcgcact tcccgggcaa aacgatctgt gggtgataaa gctttattgg
     8461 gatatcgcgg ctcgtattct atttcaatta gattcaccgt tttttcaaga gattcagcaa
     8521 acgtaccgtc tggaaatcga tcgcttgtca gccgagactt atatatatga ggatggcggt
     8581 ttcttgatcc ttcacagtca agggacccat tcttcagctt atatcgatgt ggcttcatac
     8641 tatgtcacac agaagaaaga acaggttgcc gcctggcttc aatacggcaa ggactctttg
     8701 acagacgcga tcatttatga cagcgattat gtgcgtaaat gcttcgagtg ggcagccgag
     8761 tgtgacaggt gcgattgctc gtttcttgac atgtaccaca tcattcaaga tatggatgcg
     8821 caggttttct tgtctctcat tgatgcaatg gcatcttcta acaaagcgat cattcacgtt
     8881 tctcagaaag aggcgatcag acaatgaaaa aaagcactgt ctttaccctt ttattgctgc
     8941 ttataggtat ggcggcttat tccttcggat gggttcaggc cgttgccgaa gccgccgccc
     9001 aatatgtaca gatgatcaac aatgatgctg ttcggctcgg actgctggct tgtaccgctg
     9061 ccctcctgat gctgcctgct tttctatatc ttcattatgt cacccaatcc gtgaaaaaca
     9121 tgacagcagc ttttcagaaa ctcacacagt ctcatcaaag ctgctgtgac tttcagcaac
     9181 acaacttgtg cagccgatat gcagaagacg tcaaatcgct gcgtgacagc tataaaaacg
     9241 tccgccaaac atacgtgatg gctgccgtgt tgtgccaagt catcatattc ggctgcatgt
     9301 tcgaaatcgt taaagccgtc cctttccgcc ttcacacgcc ccctgccctt tcaatgggac
     9361 ttgcgatgct actgattctg tatttattgt tttgcatgcg aacttatttg cggcagcttt
     9421 tccggcacgg cagcctgttc agaaaagtgt ttgcgggagc gctggcagca gccgggattt
     9481 ggtggatgct cagtttctct ataagtgaac tgctgtttct gattatcctg gctgccattc
     9541 agcaaatcgg atcatttatt tataaacgat tctcttatcg cagcaccgct tctcttgatc
     9601 tataaaatag ctacatcgca atcgcagacg gacccgcgcc aaccggaatc accgtcacgg
     9661 ctgtataatc acttgtgcgg tacacggtca cagcattgtc gttgggctgt gccgcataaa
     9721 tatactgttt gtccggcgtt acggcgaggt caaaagcgcc ggggagagac acgtttgcaa
     9781 tgatcctctg tctggccgta ttaactacat ataagttatt aataagaaac ggttcactat
     9841 atggctctag aaaataagct ctagtgctat cgagagaaaa tacaatcgtc ctcagcgttt
     9901 caaataaacg gctgaagtcc cctcccctgc ttaatggaga caaactaatc tccgttacac
     9961 ctttcggcca cagctcacca ttcaacacgt acgcaaaatt tccagcgtaa ggagttgcaa
    10021 ttaaactggg aaattcaaat gtatctatga tactttctac caactgccca gtatttatat
    10081 catatttatc aaccgaccaa ctgcttccat tagcggtata gacatactgt ccattcggat
    10141 caagagcaaa gtctaaagcg ccgggtatcg gaatgacatc aatgaccgat tgagaggccg
    10201 tgttaatcac atatatagat ccggcggcca tcacgtatgc gaactcatct tttggatcaa
    10261 attcgatctt tctcggccct cctccaacag taatggtatt tatgatggtt aatgttttat
    10321 tatcaatcac tgagacaagg ttggtatttc catggaggac atacgtgaat gctttatcga
    10381 aagtaacgcc tagattagtt ggcacgtcag aaaaagggat tgtttttaca acagtgttta
    10441 aatctgcatc aataaccgaa accgtgctgt ctccagtatt ggcagtaaac acatacgatt
    10501 gagggtctgg tgatggcggt aaaacaagtg tcccggtcac cgtaagcgga ctgccgtaga
    10561 aaggcggtac aatgagcaga tcttccactg ttatttgact gaaatcagga cagcggccag
    10621 actgtgctgc ataataaaca acttgatcaa tctcttcggt atgaatcaca gaaaccgccc
    10681 cattgccttg tccatattga tttcgcacag gcgacacact gacaagaagc gtaatggtcc
    10741 cttgtactct cacagcatat cgaacaccga tatcttctgg ttccggccca gtctggatta
    10801 agcaaggctc actgatacag gacacattgt ctgtactcca tgtaacagcc gctgacgctt
    10861 cggctgaatc aaccttgaag cccttaggga tatctattgg cacttgaaac ggcgcttccc
    10921 ggctaatttc ctcatcacaa aaacagaaac aattttcctg taaagcagaa agatcattct
    10981 ttttcatgaa ttcacgtcct tttagaaatg cacaacatgc agcggttaaa tcgtaatggc
    11041 acccggtgaa accccaagag atatcacagt ttcctcagaa taatcatctg tgttgtaaac
    11101 aatgatgctc tgctctataa aacgagttgc atacagaaaa tcgccattcg gggtaaacgc
    11161 atagtctgtt gctgattgcg gaagatttcc aattacacct gctccattcg gactgacaga
    11221 atataaattg ccggtaaagt cgtcatataa atacacacct gttccgctcg taaacattct
    11281 atattggccg tcaggctcca gttcttgggt attgctgatc gtaaacgtat ttaagtcaat
    11341 aaccgtcaaa taattgaata agaattcttg ttctaagaca tacgcatacc gctccggaga
    11401 atctgtttct atggatgata cgataagctc tcgttcaatc gttcctgtga cttcaccggt
    11461 ggataagtcc actttttgca ctaacccaaa attaagaaca taggcgaaca acccattggg
    11521 gtcaattgca atatcaaaac cttctatata gacctctcaa cagtcaacgt atcaattcca
    11581 atcacataaa tggcagtacc ggtgaaaaca taagcaaact catgattagg gataaatcta
    11641 atcaatcgag gcggctgatc cagcaatata gttgctgtca ctgttaatgt gtcataatcg
    11701 atgacagaaa tcacattatt gttgggatgt aagacaaaca cagcgctttt atctggcgta
    11761 atttcaatac ctgccggatt gtacggaaga gcaatcgttg tcacaacagt atgggtgttt
    11821 gtatcaatca cagaaactga ttgatcattt ggattcgctg taaacgcgta gacgggttcc
    11881 ggctccggta caagcacaat cgtccccgtc accgataaag gactgccgta aaacggcgga
    11941 acaacaacaa ggttctcaat cgtgatgtca ctgatatccg ggcaatcatc cggttcatcg
    12001 gaataataga cgacttgatc gatttctgca ttgtgaatga cggaaacagc cccgtcccct
    12061 tgtccatatt gatttcgcac aggtgagaca ctgacgagta gcgtaacggt tccctgcagg
    12121 cgcactgcaa attgaacacc gacctcatca ggctctggcc ccgtttgaat taagcaacgg
    12181 tcactgacac aagaaaggct gtctgcattc cacgtcacgt ttgcaacagc ttcagccgga
    12241 tcaacgacaa atccttcagg taactcaatc ggcgcttgaa acatggcttc tcggcttgct
    12301 tctccctcac aaaaacataa gcactcttct tgttctgctc ctgctttttc tttaaaggaa
    12361 agcttgtttt ttctcattcc ttcacttcct tttcagacat acactgctca cgcagatata
    12421 acagaatatg gaagagtaac gtgtttgctt gtacaaatta ctgagggtaa aagcttcttt
    12481 ttgaaaatat atctccaaac atgcggtgta acgaaagaaa aaattgcggt ttttttgcgc
    12541 ttctcacaag aatgttgatg ataaaatatg acatatatag aattatgaag ggagggattt
    12601 gcaaacgtga caggtgtcat atcttcttct tccatcggag aaaagattaa cgaatggtat
    12661 atgtacatac gccgattcag catacccgat gcagaatatt tgcgacgaga aatcaagcaa
    12721 gagctggatc aaatggaaga agatcaagac cttcatttgt actattcact gatggagttt
    12781 cggcacaacc tgatgcttga gtaccttgaa ccgttagaaa aaatgaggat tgaggaacag
    12841 ccgagactgt ctgatctgct gcttgagatt gataaaaaac aggctcgttt aacaggtctg
    12901 cttgagtact attttaattt cttcagaggc atgtatgagc tggatcagcg ggaatatctg
    12961 tcggctatta aatttttcaa aaaggccgaa agcaagctga tattcgttaa ggatcggata
    13021 gagaaagctg agtttttctt taagatgtct gaatcttatt actatatgaa acaaacgtat
    13081 ttttcaatgg actatgcacg gcaagcatat gaaatataca aagaaaatga agcttataat
    13141 ataagattgc tgcagtgtca ttctttattt gccaccaatt ttttagattt aaaacagtat
    13201 gaggatgccg tctcacattt tcaaaaagct tattctatgg cagaagctga aaagcagccc
    13261 caattaatgg gaagaacttt gtacaatatc gggctttgta aaaacagcca aagccaatat
    13321 gaggatgcca taacatattt caaaagagca atagctgttt ttgaagaatc aaatattctt
    13381 ccttccttac ctcaagcgta ttttttaatt acacagatcc attataaatt aggaaaaatg
    13441 gataaagctc atgaatatca tagtaaggga atggcttatt cacaaaaggc cggagatgta
    13501 atatatttat cagagtttga atttttgaaa tctttatact tatcaggccc ggatgaagaa
    13561 gcaattcaag gattttttga ttttctcgaa agtaaaatgt tgtatgctga tcttgaagat
    13621 ttcactattg atgtggcaaa atattatcat gaacgtaaaa attttcaaaa agcttctgct
    13681 tattttttga aggtggaaca agtaaggcaa cttattcaag gaggagtgag tttgtatgaa
    13741 attgaagtct aaactattac tctcttgtct ggctctaagc actgtgttcg tggcaacaac
    13801 tattgcaaat gcacctacac accaaattga agttgcacaa cgaggaatga tttaaccgcc
    13861 gtccatcggc ggtttttttg tcccctcttt acccagtctc ccaatccatt ctatgatttt
    13921 ttcaataatc ttaaaaatag tggaaatgca gcatgtctct aaaaagtgtg agaacccact
    13981 ttactcaatg gaatcgagaa aatgatgtga cggagttcga aacgtcgagt gcgacagttg
    14041 aacaggcagc tgagacaatc ggcgtaagcc tgtctagaat cgccaagtcc ctgtccttca
    14101 gaggggaagg agatcaggtg attctgattg tggcagccgg cgatgccaag atcgacaaca
    14161 aaaagtccag gcaaacattt ggctttaaag caagaatgct ctctcctaat gaggtactgg
    14221 agcagacagg ccatgaaatt ggaggagttt gcccaattgg atagactcat gatcctgag
//
