LOCUS       gnlProkkaIBGAFHOF_35   14409 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBGAFHOF_35.
ACCESSION   gnlProkkaIBGAFHOF_35
VERSION     gnlProkkaIBGAFHOF_35
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 19:06:30
            Original ID  :: gnl|Prokka|IBGAFHOF_35
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14409
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14409
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2797:4409]"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2798..4409
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    1..14409
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14409
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="sactipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     CDS             3..248
                     /locus_tag="ctg35_1"
                     /transl_table=11
                     /translation="MTRHVWEDHKEKVRQNRLSVSGKNLYKKRKEKIERSFADSKQLHG
                     LRYCRLRGKRNVSEQVLLTAACQNMKKIATYLAKQG"
     CDS             253..426
                     /locus_tag="ctg35_2"
                     /transl_table=11
                     /translation="MGALFLHLKPDEYLKKLYKTKKLVEKTSFSLQAKDKVRRLCPFDR
                     DYIFSGADTPIS"
     CDS             complement(390..2060)
                     /locus_tag="ctg35_3"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALRE
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     CDS             complement(2057..2485)
                     /locus_tag="ctg35_4"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVKGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     CDS             2798..2929
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_functions="biosynthetic-additional (sactipeptides)
                     predicted sactipeptide"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_5"
                     /sec_met_domain="Subtilosin_A (E-value: 1.7e-30, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       2798..2827
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="ctg35_5_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       2828..2929
                     /prepeptide="core"
                     /locus_tag="ctg35_5_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="32.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[2797:2827](+)"
     CDS             3132..4409
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_6"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1024.6, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 2.3e-28,
                     bitscore: 90.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6e-09, bitscore: 28.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 8.9e-24, bitscore: 77.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.9e-12, bitscore:
                     37.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.8e-11, bitscore: 36.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEIDYLRDNVSISDFEYLDLNKTAYELCMRMDGQKTAEQILAEQ
                     CAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRASRHTITTSGSNEFPMPLHATFELTH
                     RCNLKCAHCYLESSPEALGTVSIEQFKKTADMLFDNGVLTCEITGGEIFVHPNANEILD
                     YVCKKFKKVAVLTNGTLMRKESLELLKAYKQKIIVGISLDSVNSEVHDSFRGRKGSFAQ
                     TCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKVRDLGAKAFSYNWVDDFGRGRDII
                     HPTKDAEQHRKFMEYEQNVIDEFKDLIPIIPYERKRAANCGAGWKSIVISPFGEVRPCA
                     LFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRFSEHCMKDKCPFSGYCGGCYLKGL
                     NSNKYHRKNICSWAKNEQLEDVVQLI"
     CDS             4422..4583
                     /locus_tag="ctg35_7"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGM
                     RARKADSR"
     CDS             4580..5299
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 124.3; E-value:
                     1.1e-37)"
                     /gene_kind="transport"
                     /locus_tag="ctg35_8"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKTREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     CDS             5292..6602
                     /locus_tag="ctg35_9"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNAYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     LMFLLHAAIFACVCLSAALMPAATLPLCAVHMLWAVVIDFPVFLQAPPQQSRMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAAFSGFFSFQMMNTGIFNQQVIYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKGKTMFWAKYRFYSGLLAGEFLLVVMIVGFISGRPIS
                     VLTFLQCIELLLAGAFIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPLFLATLAG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     CDS             6568..7752
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_10"
                     /sec_met_domain="Peptidase_M16_C (E-value: 1.1e-06,
                     bitscore: 21.2, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQAKENGLEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYF
                     YGAAAYLKEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKT
                     FADLSFPSSLSFEAVEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRK
                     DRIKAIHPKRFLDATDFTVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSERIPVNRH
                     VFETETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAV
                     YHVITRYDVMNNLLLVSICTDQLHEIDIPPRVLEAVSAFHTDERELEQAKQFLRNELLL
                     QFDSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     CDS             7757..9037
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_11"
                     /sec_met_domain="Peptidase_M16 (E-value: 4.7e-15, bitscore:
                     48.2, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCLRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYHSERKIIPACPPALSQKMVLGDEERMEDTWTGLQIGALPGQNDLLTIKLYWDIA
                     SRILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQQKEQVTSWLQYGKDSLTDAIIYDSDYVRKCFEWAAECGRCDCSFLDMYHIIQDMDTQ
                     VFLSLIDAMASSNKAIIHVSQKEAIRQ"
     CDS             9034..9735
                     /locus_tag="ctg35_12"
                     /transl_table=11
                     /translation="MKKNTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPALSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGVLAAAGIWWMLSFSISELLFLIILAAIQQIGSFIYKR
                     FSYRSTASLDL"
     CDS             complement(9741..11117)
                     /locus_tag="ctg35_13"
                     /transl_table=11
                     /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDIPEGFKVDSAEAS
                     AAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGDGA
                     VSVIHTEEIDQVVYYAAQSDRCPDFSQMTVEDLLIVPPFYGSPLTVAGTLVLPPSPDPQ
                     SYVFTANTGDSTVSVIDADLNTVVKTIPFSAVPTNLGVTFDKAFTYILHGNTNLVSVID
                     NKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPGALDFA
                     LDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDSFEFPSLIATPYAGNFAYVLNGELW
                     PKGVTEISLSPLSRGGDFSRLFETLMTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTAR
                     QRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVGAGPSAIAM
                     "
     CDS             complement(11156..12511)
                     /locus_tag="ctg35_14"
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISDITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANPNDQSVSVIDTNTHTVVTTIALPYNPAGIEITPDKSAVFVLHPNNNV
                     ISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAIYVIGIDTLTVERSIPVEG
                     FDIAIDPNGLFAYVLNFGLVQKVDLSTGEVLGTIERELIVSSIETDSTERYAYVLEQEF
                     LFNYLTVIDLNTFTIRDTQELEPDGLYVMFTSGSEVYLHDSFTGNLYSVSPNGAGVIGN
                     LPQSATDYAFTPNGDFLYTTRFIEQSIIVYNTDDYSVETVISLGVSPGAITI"
     CDS             12741..13886
                     /locus_tag="ctg35_15"
                     /transl_table=11
                     /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFSMDY
                     ARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQPQLMG
                     RTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLGKMDKA
                     HEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYADLEDFA
                     IDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV"
     CDS             13870..13989
                     /locus_tag="ctg35_16"
                     /transl_table=11
                     /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI"
ORIGIN
        1 tgattactcg acatgtatgg gaagatcata aagaaaaggt cagacaaaat cgcttgtctg
       61 tttcaggaaa aaacctctac aaaaaaagaa aagaaaaaat agagcgaagc tttgcagatt
      121 caaaacagct gcatgggctt cgctattgca ggttgagggg aaaacgaaat gtgagtgaac
      181 aagttctcct cacagccgca tgccagaaca tgaagaagat tgccacatac ctagccaagc
      241 agggctaggc atgtgggagc gctttttctg catctgaaac ctgatgaata tctaaagaaa
      301 ctgtataaaa caaaaaagct tgtagaaaaa acgtcgtttt ctctacaagc taaggacaaa
      361 gtccgaagac tttgtccttt tgatcgtgat tacatttttt ccggagccga tacgccgatc
      421 agctgaagcg cattgttcag cgtaatttgc gttgccttca ttaaagccag gcgcgcgcgg
      481 cttttctctt cattttcagg gtcgatgact ttctctgcgt tgtagaagct gtgcagagca
      541 gaggccagat cataaatata gtttgtgaca cggtgcggaa ttcgtttttc cgctgcttcc
      601 gccactgcct ctgggaagcc gccgatcgtt ttcagcagat cgtattcttt ttctgattga
      661 atatggctga aatcaagatc cgccgccggt ttaagtccct gctcttcccc ttggcgaagc
      721 atgctgcaga ttcgggcatg tgcatattgt gcataataca cagggttttc gttagatgtt
      781 gatacagcaa gatctaagtc aaaatccata tgggtgtccg cacttcgcat cgcaaagaag
      841 taacgaacgg catccaagcc gacttcttca atcaggtcac gcatcgttac ggctttaccg
      901 gtccgtttgc tcattttcat tttctcgccg tttttgtaaa ggtgaacgag ctgaatgatt
      961 tctacttcaa gcgttccttt ttcatagccc agcgcttcga ttgccgcttt catacgcggg
     1021 atgtagccgt ggtgatcggc gccccaaacg ttgatcagct tatcaaagcc gcggtcaagc
     1081 ttgtccttat gatacgcgat atcaggaagc aggtacgtgt acgtgccgtc cttcttgatc
     1141 aatacgcggt ctttatcatc gccaaacgtc gtggaacgga accaagtcgc gccgtcttct
     1201 tcatagacat ggcctttttc gcggagcgct tcaagcgcct tgtcgatttt tccattttgg
     1261 tacagtgaag tttctgaata ccacacatca aacggcacac ggaagttttc caagtccttg
     1321 cgaagctttt ccagctcata tttcaggccg tattcacgga aaaacgcgag gcgttcactt
     1381 tcttcttcgt taacgaaacg atcaccgtat tcctcagcga gacgctttcc gatcgcaatg
     1441 atatcctcgc cgcggtagcc atcctccggc atcggttttt ccaatccgag tgcttcaaag
     1501 taacggactt caacagaaag cgccagattg ttgatttggt tacccgcatc gttaatgtag
     1561 tattcgcggc ttacatcgta acccgctttt gaaagcacgt tgcacaagga atcgccgaca
     1621 gccgccccgc gcgcatgccc gaggtgaagg tctcccgtcg gattcgctga tacgaattct
     1681 acctgaactc gttcaccgtt tccgatgttc gtttccccgt atgcttcccc tgcttccagt
     1741 acagacggaa tcagctttgt taaatattga ttgttcatat agaaattgat aaaacccggg
     1801 ccggcgatat ccagtttttc aatcgaagcc tttcctttat caaaatgggc gacaatctct
     1861 tcagcgattt ggcgcggcgc tttttttgcc actcttgcca gctgcatcgc catattcgtt
     1921 gagtagtcgc cgtgtgtttt atctttcggt gtttctaaaa caacattggg aatctggctt
     1981 tcttcagcca gtcccgcttt cagaacggcc gctttgattt cttctttcag cacgtccttc
     2041 atttgttccg caatgttcat gcgtgagttc ctccctcata cgtgatcgtc atattatgta
     2101 aatgctcctg ctcgtctccg acatgcatgt catatgcgat gctgatacgg cctttttctt
     2161 catcgagatc agattgaatc gattttgtgc ttgttttcag ctcaagctca ccaaatgaca
     2221 ttttatattt agcaattgtg gaagctccct ttacgaaacg ctgattcatt ttgacagcgc
     2281 ctgacctcat gaccaggact tcgccttcgc ttactttcac aatcgttttg actttgccta
     2341 agtcgtgttc ttcataataa gatagataca ctttattttg ttttacatag taaaatccgg
     2401 tggtgcggaa ttcgatgact tcttggtttc cgtcatcctc gatcacagac ttcacatgga
     2461 gtgttatcgg tgtctcttgc ttcattctga cacgtccttt tcatcattcc actttgactt
     2521 gaatagtata atcattcggt ttgtaaactt caactgcttc tatcttacca tcattgctca
     2581 tcagatttga agataaacct cataaaaagc atttccttat atagaagaga aaatcatatc
     2641 actaattacc tttaggaaat gttacatttt tccgaaatct atcatttcct tttcacattt
     2701 ttttcaaaat atatgtattg aattagtaat ttgatagttt taagataaaa gtacaacata
     2761 gatctgctag aaaaacaaaa aaagggagga ttcaattatg aaaaaagctg tcattgtaga
     2821 aaacaaaggt tgtgcaacat gctcgatcgg agccgcttgt ctagtggacg gtcctatccc
     2881 tgattttgaa attgccggtg caacaggtct attcggtcta tgggggtaag gatctcccaa
     2941 aagggcatag tcattctact atgccctttt taagtaaatt acaattttta actaaaatct
     3001 acctcttgga tatacataca caaccgtttt tcatttgaat catatgtata ggggatggta
     3061 ttttgtttat agagcagatg tttccattta ttaatgaaag tgtaagggtt caccagcttc
     3121 ctgagggcgg cgtgttagaa atcgactact tgcgcgataa tgtctccatt tctgactttg
     3181 agtatttgga tctcaacaaa acggcttacg agctttgcat gcgcatggat ggccaaaaaa
     3241 cagctgagca gattttagct gagcaatgtg cagtgtatga tgaatcaccg gaagaccata
     3301 aagattggta ttacgacatg ctcaacatgc tccagaacaa gcaggttatt cagcttggaa
     3361 accgggccag ccgccataca atcaccacga gcggaagcaa tgaatttccg atgcccctgc
     3421 acgccacctt tgaactgacg caccgctgta atttgaaatg cgcccactgt tatttggaaa
     3481 gctcacctga agcgctcggc accgtgtcga ttgagcaatt caaaaaaacg gctgatatgc
     3541 tgtttgataa cggtgtattg acatgcgaaa tcacaggcgg agaaattttt gtccatccaa
     3601 acgccaatga gattcttgac tatgtgtgta aaaagttcaa aaaagtcgct gtcttaacaa
     3661 acggaacact catgcgaaaa gagagcctgg agcttttgaa ggcttacaag caaaaaatca
     3721 tcgtcggcat ttctcttgat agtgtcaatt ccgaggtcca tgactccttt agagggagaa
     3781 aaggctcttt tgcccaaact tgtaaaacga taaaattgtt gagtgaccac ggtatatttg
     3841 tcagagtcgc catgtctgtc ttcgaaaaaa acatgtggga aatccacgat atggcccaaa
     3901 aggttcggga tctcggagcg aaggcgtttt cttacaattg ggttgacgat ttcggaagag
     3961 gcagggatat tatccatcca acgaaagacg ccgagcagca ccgcaagttt atggaatacg
     4021 agcaaaatgt gattgatgag tttaaagatc tgattccgat tattccctat gagagaaaac
     4081 gcgcggcaaa ttgcggcgct ggctggaagt ccattgtgat cagcccgttc ggcgaagtac
     4141 gtccttgcgc cctctttcca aaggaatttt cattgggaaa tatttttcat gattcctatg
     4201 aaagcatctt taactcccct ctcgtccata aactgtggca agcgcaggcg ccgcggttca
     4261 gcgaacattg catgaaagac aaatgcccgt tcagcggcta ttgcggaggc tgttacttaa
     4321 aagggctgaa ctctaacaaa tatcaccgaa aaaacatttg ctcttgggcg aaaaatgaac
     4381 aattagaaga cgtggtccag cttatttagg agggaaacga tttgtcacca gcacaaagaa
     4441 gaattttact gtatatcctt tcatttatct ttgtcatcgg cgcagtcgtc tattttgtca
     4501 aaagcgatta tctgtttacg ctgattttca ttgccattgc cattctgttc ggaatgcgcg
     4561 cgcggaaggc tgactcgcga tgagcatttt ggatatacac gatgtatccg tttggtatga
     4621 acgggacaac gtcatcttag aacaagtgga tttacattta gaaaaaggcg ccgtttacgg
     4681 gctgcttggg gtaaacggcg ccggaaaaac gacactgatt aatacgctga caggcgtgaa
     4741 ccgcaatttc agcgggcgct ttacactgtg cggaattgaa gcggaggccg gcatgccgca
     4801 gaaaacatca gatcagctga agactcaccg ttacttcgcc gccgattatc cgctgctatt
     4861 tacagaaatt acggcgaagg actatgtgtc tttcgtccat tcgctttatc aaaaggattt
     4921 ttcagagcag cagtttgcca gtttggccga ggcctttcat ttttcgaaat acatcaacag
     4981 gagaatttcg gagctgtcct tggggaacag gcaaaaggtt gtattgatga caggcttatt
     5041 gctgcgcgct cccctattta ttttggatga gccgctcgtc ggtttggatg tggaatcgat
     5101 agaggttttt tatcagaaaa cgcgcgagta ctgtgaagca ggcgggacca ttttgttttc
     5161 ttctcatctg ctcgatgtcg tgcaaagatt ttgtgattac gcggccattc ttcacaacaa
     5221 acagatccaa aaggtcattc cgattggaga ggagaccgat ctgcggcggg aatttttcga
     5281 ggtgatcggc catgaataac ataatcccca tcatgtcttt gctgttcaaa cagctttaca
     5341 gccggcaagg gaaaaaggac gccatccgca ttgccgcagg ccttgtcatt ctggccgtat
     5401 ttgaaatcgg gctgatccgc caggccggca ttgatgaatc ggtgttgcgc aaaacgtata
     5461 tcatactcgc gcttctctta atgaacgcat atatggtgtt tctttctgtg acatctcaat
     5521 ggaaggaatc ttatatgaaa ctgagctgcc tgctgccgat ttcttcacgg agcttttggc
     5581 tcgcccagag tgtcgttttg tttgtcgata cctgtttgag aagaacgtta ttctttttta
     5641 ttttaccgct gttcttattt ggaaacggaa cgctgtcagg ggcgcaaaca ttgttttggc
     5701 tcggcaggtt ttcgtttttt accgtttact ccattatttt cggagttgtg ctaagcaacc
     5761 acttcgtcaa aaagaagaac ttgatgtttc tgctgcatgc ggcgatattc gcctgtgtat
     5821 gtctcagcgc cgctttgatg ccggccgcca cgcttccgct ttgcgcggtg catatgctgt
     5881 gggcggtggt cattgacttt cctgtctttc tgcaggcgcc tccgcagcag agcaggatgc
     5941 attcatttat gcggcgatct gagttttcgt tttacaaaag agaatggaac cgatttatct
     6001 cttctaaagc gatgctgtta aattacgcgg taatggcggc gttcagcggc ttcttttcgt
     6061 tccagatgat gaataccggc atcttcaatc agcaagtgat ttatatcgtg atttccgcgc
     6121 ttctgctcat ctgctcgccg atcgcccttt tgtactcgat tgaaaaaaat gaccggatgc
     6181 tgctcatcac gcttccgatc aaggggaaaa cgatgttttg ggcgaaatat cgcttttatt
     6241 caggcctatt ggcaggcgaa tttctccttg tcgtgatgat tgtgggtttc atcagcggcc
     6301 gtccgatttc agttctcact tttttgcagt gcattgagtt gctgctggcg ggagctttta
     6361 tcaggttaac tgcggatgaa aaaaggccct ccttcagctg gcagacggag cagcagctat
     6421 ggagcggttt ctcaaaatat cggtcttatc tgttttgtct tcccctattc ttagccacat
     6481 tagccggcac cgctgtatcc ttggcggtca ttccgatagc cggtctggtc atagtctatt
     6541 acctgcaaaa acaggatggt ggtttctttg atacaagcaa aagagaacgg cttggaagtt
     6601 aacctgctga agactcatca attttcaact atttcaatcg ccgcgagctt tctgaaaccg
     6661 atcgaaagcg cggcggaacc tgaggaagaa acaatttatt tttacggcgc cgccgcatac
     6721 ctgaaggagc aaatcattga cgcttttggt tatgctgccg gcagccgttt catgtactca
     6781 gcgaatctct tttttgatca gcagctgaaa acctgcggga cccgtttgat tcacccatta
     6841 tataacggga atcttcatgt tgacgccctg atgaaaactt ttgcagactt gtctttccct
     6901 tcttctcttt cattcgaagc agttgaaaag gccaggaatg agctgctgct gaaaatcgaa
     6961 aagaaattca ctgatccctt ctcctactcg gcggctcgct tggctgagga ggtcttcgga
     7021 aacccgatgt acggcacagg catgtttggc cggaaagaca ggataaaggc gattcatcct
     7081 aaacggtttc tcgacgcaac ggactttacc gttgatttag tgtcccagca aaaacagctg
     7141 aacatattgg gacaagtaca agcatgtgat gttcggggac atgccccgca aacgtccgct
     7201 gtaacgtccg aaagaatacc cgtaaaccgg catgtttttg aaacagagac tcgcagcgct
     7261 gcaggtcctt ccgtcttgac actcggattt gactgcggag agatgaaaga tgccagcgat
     7321 tatatcaaaa tacagctaat agacggatta ctgggaaagt acggccattc cgctttattc
     7381 aagcacttca gagagaagga tctggcagtc tatcacgtta tcacccgtta cgatgtcatg
     7441 aacaatttgc tgcttgtttc aatatgtaca gatcagcttc atgagataga cattcccccg
     7501 cgcgttttgg aagctgtttc agcttttcat acagatgaga gggaactaga acaggcaaag
     7561 cagtttttac gcaatgaatt gctgctgcaa ttcgattctc ccgaaggtct attggcctat
     7621 atgggggtcc tgcgccgctt ctcctgcacg aaagaagcct tgctggatgg catctcagcg
     7681 gttacatgcc gcgatgtatt gcaattcata gcgaccatca attatatcgg agctcatgta
     7741 gtaaggggat gaagagatgg aaaagaaagc cttttttcaa cagctggatg aacgaaccga
     7801 tatcagatac acagacagcg gactaaaaat attcagattg aaattccccc gcgcccacct
     7861 gcggctgtgc aatgtaaaaa tcgattttgg aagccgggat gtatgtttac gggcagaatc
     7921 cggtgataca ctgcttccgt atggcacagc gcatttttta gagcatcttc tcttctggca
     7981 taacggccgc aatctgtaca gtgatttttt tgcgcatggc gcgcttttaa acgcattcac
     8041 tacctacacc gataccaatt tcatgtttac ctcattaccg gatcggctca gacaaacgat
     8101 ccccatcctg cttgatgctt tatggaacca ctcatttgac aagaagattg tcgctcagga
     8161 aaaagctgtg attacaagcg aaattcaaac agcacacctt aaccatcagc tctcatatca
     8221 ttatcagctg atcagcatgc tttctccctc ctcaccagct gccgttttcc ccgcaggcag
     8281 aatcgaagat attgaggcgc tggacatcag tgatttacaa aaagcctata aggctgccta
     8341 ccaagcccat cggatgacgc tgtttttgat tgggggctca gaaaatacag aaacgctttt
     8401 gcctcctcac ctccagctgg aaaagcgtcc ggattatcat tctgaaagaa aaatcatccc
     8461 ggcatgccct ccagccctct cacaaaaaat ggtgctgggt gatgaggagc ggatggaaga
     8521 tacctggacc ggcttacaga tcggcgcact tcccgggcaa aacgatctgt tgacgataaa
     8581 gctttattgg gatatcgcgt ctcgtattct atttcaatta gattcaccgt tttttcaaga
     8641 gattcagcaa acgtaccgcc tagaaatcga tcgcttgtca gccgagactt atatatatga
     8701 ggatggcggt ttcttgatcc ttcacagtca agggacccat tcttcagctt atatcgatgt
     8761 cgcatcatac tatgtcacgc agcagaaaga acaggttacg tcctggcttc aatacggcaa
     8821 ggactctttg acagacgcga tcatttatga cagcgattat gtgcgtaaat gcttcgagtg
     8881 ggcagccgag tgtggcaggt gcgattgctc gtttcttgac atgtaccaca tcattcaaga
     8941 tatggatacg caggttttct tgtctctcat tgatgcaatg gcatcttcta acaaagcgat
     9001 cattcatgtt tctcagaaag aggcgatcag acaatgaaaa aaaacactgt ctttaccctt
     9061 ttattgctgc ttataggtat ggcggcttat tccttcggct gggttcaggc cgtggccgaa
     9121 gccgccgccc aatatgtaca gatgatcaac aatgacgctg tgcggctcgg gctgctggct
     9181 tgtactgctg ccctcctgat gctgcctgct tttctctatc ttcattatgt cacccaatcc
     9241 gtgaaaaaca tgacagcagc ttttcagaaa ctcacacagt ctcatcaaag ctgctgtgac
     9301 tttcagcaac acaacttgtg cagccgatat gcagaagacg tcaaatcgct gcgtgacagc
     9361 tataaaaacg tccgccaaac atacgtgatg gctgccgtgt tgtgccaagt catcatattc
     9421 ggctgcatgt tcgaaatcgt taaagccgtc cctttccgcc ttcatacgcc ccctgccctt
     9481 tcaatgggac ttgcgatgct actgatcctg tatttattgt tttgcatgcg aacgtatttg
     9541 cggcagcttt tccggcacgg cagcctgttc agaaaagtgt ttgcgggagt gctggcagca
     9601 gccgggattt ggtggatgct cagtttctct ataagtgaac tgctgtttct gattatcctg
     9661 gctgccattc agcaaatcgg atcatttatt tataagcgat tctcttatcg cagcaccgct
     9721 tctcttgatc tataaaatag ctacatcgca atcgcagacg gacccgcgcc aaccggaatc
     9781 accgtcacgg ctgtataatc acttgtgcgg tacacggtca cagcattgtc gttgggctgt
     9841 gccgcataaa tatactgttt gtccggcgtt acggcgaggt caaaggcgcc ggggagagac
     9901 acgtttgcaa tgatcctctg tctggccgta ttaactacat ataagttatt aatgagaaac
     9961 ggttcactat atggctctag aaaataagct ctagtactat cgagagaaaa tacaatcgtc
    10021 atcagcgttt caaataaacg gctgaagtcc cctcccctgc ttaatggaga caaactaatc
    10081 tccgttacac ctttcggcca caactcacca ttcaacacgt acgcaaaatt tccagcgtaa
    10141 ggagttgcaa ttaaactggg aaattcaaat gaatctatga tactttctac caactgccca
    10201 gtatttacat catatttatc aaccgaccaa ctgcttccat tagcggtata gacatactgt
    10261 ccattcggat caagagcaaa gtctaaagcg ccgggtatcg gaatgacatc aatgaccgat
    10321 tgagaggccg tgttaatcac atatatagat ccggcggcca tcacgtatgc gaactcatct
    10381 gttggatcaa attcgatttt tctcggccct cctccaacag taatggtatt tatgatagtt
    10441 aatgttttat tatcaatcac tgagacaagg ttggtatttc catggaggat atacgtgaat
    10501 gctttatcga aagtaacgcc tagattagtt ggcacagcag aaaacgggat tgtttttaca
    10561 acagtgttta aatctgcatc aatgaccgaa accgtgctgt ctccagtatt ggcagtaaac
    10621 acatatgatt gagggtctgg cgatggcggt aaaacaagtg tcccggccac cgtaagcgga
    10681 ctgccgtaga aaggcggtac aatgagaaga tcttccactg tcatttgact aaaatcagga
    10741 cagcggtcag actgtgctgc ataataaaca acttgatcaa tctcttcggt atgaatcacc
    10801 gaaacagccc cgtctccttg tccatattga tttcgtacag gcgacacact gacaagaagc
    10861 gtaatggtcc cttgtactct cacagcatat cgaacaccga tatcttctgg ttccggccca
    10921 gtctggatta agcaaggctc actgatacag gacaaattgt ctgtactcca tgtaacagcc
    10981 gctgacgctt ctgccgaatc aaccttgaag ccctcaggga tatctatcgg cacttgaaac
    11041 ggcgcttccc ggctaatttc ctcatcacaa aaacagaaac aattttcctg taaagcagaa
    11101 agatcattct ttttcatgat ttcacgtcct tttagaaatg cacaacatgc agcggttaaa
    11161 tcgtaatggc acccggtgaa accccaagag atatcacagt ttccacagaa taatcatctg
    11221 tgttgtaaac aatgatgctc tgctctataa aacgagttgt atacagaaaa tcgccattcg
    11281 gggtaaacgc atagtctgtt gctgattgcg gaagatttcc aattacacct gctccattcg
    11341 gactgacaga atataaattg ccagtgaagc tgtcatgtaa atacacctct gatccactcg
    11401 taaacattac atatagcccg tcaggctcca gctcttgggt atccctgatc gtaaacgtat
    11461 ttaaatcaat aaccgtcaaa taattgaata agaattcttg ttctaataca tacgcatacc
    11521 gctccgtaga atctgtttct atggatgata cgataagctc tcgttcaatc gttcctaaga
    11581 cttcaccggt agataagtcc actttttgca ctaacccaaa attaagaaca taggcgaaca
    11641 acccattggg gtcaattgca atatcaaaac cttctacagg aatagacctc tcaacagtca
    11701 acgtatcaat tccaatcaca taaatggcag taccggtgaa aacataagca aactcatgat
    11761 tagggataaa tctaatcaat cgaggcggct gatccagcaa tatagttgct gtcactgtta
    11821 atgtgtcata atcgatgaca gaaatcacat tattgttggg atgtaagaca aacacagcgc
    11881 ttttatctgg cgtaatttca atacctgccg gattgtacgg aagagcaatc gttgtcacaa
    11941 cagtatgggt gtttgtatca atcacagaaa ctgattgatc atttggattc gctgtaaacg
    12001 cgtagacggg ttccggctcc ggtacaagca caatcgtccc cgtcaccgat aaaggactac
    12061 cgtaaaacgg cggaacaaca acaaggttct caatcgtgat gtcactgata tccgggcaat
    12121 catccggttc atcggaataa tagacgactt gatcgatttc tgcattgtga atgacggaaa
    12181 cagccccgtc cccttgtcca tattgatttc gcacaggtga gacactgacg agtagcgtaa
    12241 cggttccctg caggcgcact gcaaattgaa caccgacctc atcaggctct ggccccgttt
    12301 gaattaagca acggtcactg acacaagaaa ggctgtctgc attccacgtc acgtttgcaa
    12361 cagcttcagc cggatcaacg acaaatcctt caggtaactc aatcggcgct tgaaacatgg
    12421 cttctcggct tgcttctccc tcacaaaaac ataagcactc ttcttgttct gctcctgctt
    12481 tttctttaaa ggaaagctta ttttttctca ttccttcact tccttttcag acatacactg
    12541 ctcacgcaga tataacagaa tatggaagag taacgtgttt gcttgtacaa attactgagg
    12601 gtaaaagctt ctttttgaaa atatatctcc aaacatgcgg tgtaacgaaa gaaaaaattg
    12661 cggttttttt gcgcttctca caagaatgtt gatgataaaa tatgacatat atagaattat
    12721 gaagggaggg atttgcaaac gtgacaggtg tcatatcttc ttcttccatc ggagaaaaga
    12781 ttaacgaatg gtatatgtac atacgccgat tcagcatacc cgatgcagaa tatttgcgac
    12841 gagaaatcaa gcaagagctg gatcaaatgg aagaagatca agaccttcat ttgtactatt
    12901 cactgatgga gtttcggcac aacctaatgc ttgagtacct tgaaccgtta gaaaaaatga
    12961 ggattgagga acagccgaga ctgtctgatc tgctgcttga gattgataaa aaacaggctc
    13021 gtttaactgg tctgcttgag tactatttta acttcttcag aggcatgtac gagctggacc
    13081 agcgggaata tctgtcggct attaaatttt tcaaaaaggc cgaaagcaag ctgatattcg
    13141 ttaaggatcg gatagagaaa gctgagtttt tctttaagat gtctgaatct tattactata
    13201 tgaaacaaac gtatttttca atggactatg cacggcaagc atatgaaata tacaaagaac
    13261 atgaagctta taatataaga ttgctgcagt gtcattcttt atttgccacc aattttttag
    13321 atttaaaaca gtatgaggat gccatctcac attttcaaaa agcttattct atggcagaag
    13381 ctgaaaagca gccccaatta atggggagaa ctttgtacaa tatcgggctt tgtaaaaaca
    13441 gccaaagcca atatgaggat gccatacctt atttcaaaag agcaatagct gtttttgaag
    13501 aatcaaatat tcttccttcc ttacctcaag cgtatttttt aattacacag atccattata
    13561 aattaggaaa aatggataaa gctcatgaat atcatagtaa gggaatggct tattcacaaa
    13621 aggccggaga tgtaatatat ttatcagagt ttgaattttt gaaatcttta tacttatcag
    13681 gcccggatga agaagcaatt caaggatttt ttgattttct cgaaagtaaa atgttgtatg
    13741 ctgatcttga agatttcgct attgatgtgg caaaatatta tcatgaacgt aaaaattttc
    13801 aaaaagcttc tgcttatttt ttgaaggtgg aacaagtaag gcaacttatt caaggaggag
    13861 tgagtttgta tgaaattgaa gtctaaacta ttactctctt gtctggctct aagcactgtg
    13921 ttcgtggcaa caactattgc aaatgcacct acacaccaaa ttgaagttgc acaacgagga
    13981 atgatttaac cgccgtccat cggcggtttt tttgtcccct ctttacccag tctcccaatc
    14041 catgctatga ttttttcaat aatcttaaaa atagtggaaa tgcagcatgt ctctaaaaag
    14101 tgtgagaacc cactttactc aatggaatcg agaaaatgat gtgacggagt tcgaaacgtc
    14161 gagtgcgaca gttgaacagg cagctgagac aatcggcgta agcctgtcta gaatcgccaa
    14221 gtccctgtcc ttcagagggg aaggagatca ggcgattctg attgtggcag ccggcgatgc
    14281 caagatcgac aacaaaacgt tcaggcaaac atttggcttt aaagcaagaa cgctctctcc
    14341 taatgaggtg ctggagcaga caggccatga aattggagga gtttgcccat ttggattggc
    14401 tcatgatcc
//
