LOCUS gnlProkkaGAMLCGEA_21 34420 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|GAMLCGEA_21. ACCESSION gnlProkkaGAMLCGEA_21 VERSION gnlProkkaGAMLCGEA_21 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 19:36:14 Original ID :: gnl|Prokka|GAMLCGEA_21 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 34420 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..34420 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[7283:14420]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 7284..14420 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" protocluster 1..34420 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[2653:14420]" /cutoff="30000" /detection_rule="(VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))" /neighbourhood="20000" /product="NRP-metallophore" /protocluster_number="2" /tool="antismash" proto_core 2654..14420 /aStool="rule-based-clusters" /tool="antismash" /cutoff="30000" /detection_rule="(VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))" /neighbourhood="20000" /product="NRP-metallophore" /protocluster_number="2" cand_cluster 1..34420 /SMILES="NCC(=O)NC(C(O)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="chemical_hybrid" /product="NRP-metallophore" /product="NRPS" /protoclusters="2" /protoclusters="1" /tool="antismash" region 1..34420 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRP-metallophore" /product="NRPS" /region_number="1" /rules="(VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" CDS complement(82..684) /locus_tag="ctg21_1" /transl_table=11 /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQP FFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPAAF VAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGFMIW FMAKDTALAVILSFIAPAIYRSIHKATGFNRNHISSM" CDS 787..1395 /locus_tag="ctg21_2" /transl_table=11 /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGNVPYYEDMTKWNLQ VYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKEEA GYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLPPEHGFPLRGVFPHLYFWKSAKW LRGIQFTKENHPGFWERNGYQRRSVEKSKIYMGLRFYFK" CDS 1580..2461 /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_S9" /gene_kind="biosynthetic-additional" /locus_tag="ctg21_3" /sec_met_domain="Peptidase_S9 (E-value: 3.1e-08, bitscore: 26.0, seeds: 64, tool: rule-based-clusters)" /transl_table=11 /translation="MSYCMKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFIS KPSTPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFS SARHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTI FGHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILEKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAILSEQGIRAEFCEFSGEGHISVLPVLVSRALRF ALHPDGPHLSMG" CDS 2654..3439 /NRPS_PKS="Domain: PKS_KR (11-167). E-value: 2.6e-16. Score: 51.9. Matches aSDomain: nrpspksdomains_ctg21_4_PKS_KR.1" /gene_functions="biosynthetic (rule-based-clusters) NRP-metallophore: EntA" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short_C2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001:short-chain dehydrogenase/reductase SDR (Score: 255.3; E-value: 9.7e-78)" /gene_kind="biosynthetic" /locus_tag="ctg21_4" /sec_met_domain="EntA (E-value: 1.7e-119, bitscore: 390.8, seeds: 34, tool: rule-based-clusters)" /sec_met_domain="adh_short (E-value: 1.1e-39, bitscore: 128.9, seeds: 230, tool: rule-based-clusters)" /sec_met_domain="adh_short_C2 (E-value: 7.8e-35, bitscore: 113.6, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKL EKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREIGPIDILVNVAGVLRPGLIHSL SDEEWEATFSVNSTGVFNVSRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASSKAA AVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPL KKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV" aSDomain 2687..3154 /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_4_PKS_KR.1" /evalue="2.60E-16" /label="ctg21_4_PKS_KR.1" /locus_tag="ctg21_4" /protein_end="167" /protein_start="11" /score="51.9" /specificity="KR activity: inactive" /specificity="KR stereochemistry: C1" /tool="antismash" /translation="FITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEG RHAEAFPADVRDSAAIDEITARIEREIGPIDILVNVAGVLRPGLIHSLSDEEWEATFSV NSTGVFNVSRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASSKAAAVMF" CDS_motif 2690..2752 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_4_0001" /evalue="3.50E-05" /label="PKSI-KR_m1" /locus_tag="ctg21_4" /protein_end="33" /protein_start="12" /score="16.4" /tool="antismash" /translation="ITGAAQGIGEAVARTLASQGA" CDS_motif 3026..3082 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_4_0002" /evalue="5.20E+00" /label="PKSI-KR_m1" /locus_tag="ctg21_4" /protein_end="143" /protein_start="124" /score="-0.1" /tool="antismash" /translation="RSVSKYMMDRRSGSIVTVG" CDS 3465..4661 /gene_functions="biosynthetic (rule-based-clusters) NRP-metallophore: EntC" /gene_functions="biosynthetic-additional (smcogs) SMCOG1018:isochorismate synthase (Score: 419; E-value: 4.8e-127)" /gene_kind="biosynthetic" /locus_tag="ctg21_5" /sec_met_domain="EntC (E-value: 2.1e-156, bitscore: 513.8, seeds: 49, tool: rule-based-clusters)" /transl_table=11 /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPEA DGQNQMETLSGRIAETLRQAKQSGQSRPLVVGAVPFDQVKPARLVVPEEVRWSGPLQFD HEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLTRIADGTLSKIVLSRSLHLTSPEPIQTD ELLRHLAQHNTHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAGSRPR SNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTETMWHL SSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTGMVGWCD DAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRAMGVDHI" CDS 4679..6298 /NRPS_PKS="Domain: AMP-binding (31-435). E-value: 7.5e-87. Score: 283.4. Matches aSDomain: nrpspksdomains_ctg21_6_AMP-binding.1" /gene_functions="biosynthetic-additional (rule-based-clusters) AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002:AMP-dependent synthetase and ligase (Score: 489.3; E-value: 1.7e-148)" /gene_kind="biosynthetic-additional" /locus_tag="ctg21_6" /sec_met_domain="AMP-binding (E-value: 4.8e-95, bitscore: 311.1, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAIT CGNTHWSYQELDTRVDRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALPVF ALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRTLARQVQSKLPTLKNIIVAGEAEEF LPLEDLHTEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDH STVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPP LAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAEGLVNYT RLDDPEEIIVNTQGKPMSPYDEVRVWDDQDRDVKPGETGHLLTRGPYTIRGYYKAEEHN AASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDA AMVSMPDQFLGERSCVFIIPRDEALKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGV GKVSKKALREAISEKLLAGAKK" aSDomain 4772..5983 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_6_AMP-binding.1" /evalue="7.50E-87" /label="ctg21_6_AMP-binding.1" /locus_tag="ctg21_6" /protein_end="435" /protein_start="31" /score="283.4" /specificity="substrate consensus: diOH-Bz" /tool="antismash" /translation="RDRAAKYGDRIAITCGNTHWSYQELDTRVDRLAAGFQKLGIQQMD RVVVQLPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSGF DYRTLARQVQSKLPTLKNIIVAGEAEEFLPLEDLHTEPVKLPEVKSSDVAFLQLSGGST GLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRV VLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSA EAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGKPMSPYDEVRVWDDQDR DVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAK DQINR" CDS_motif 5801..5887 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_6_0001" /evalue="2.10E-03" /label="NRPS-A_a6" /locus_tag="ctg21_6" /protein_end="403" /protein_start="374" /score="10.6" /tool="antismash" /translation="PGETGHLLTRGPYTIRGYYKAEEHNAASF" CDS 6326..7264 /NRPS_PKS="Domain: PP-binding (234-293). E-value: 4.4e-12. Score: 38.3. Matches aSDomain: nrpspksdomains_ctg21_7_PP-binding.1" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1027:isochorismatase (Score: 408.3; E-value: 1.8e-124)" /gene_kind="biosynthetic-additional" /locus_tag="ctg21_7" /sec_met_domain="PP-binding (E-value: 7.9e-12, bitscore: 38.3, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVDA FTAGASPVIELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSGPY EEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVTACE AFMEDIKAFFVGDAVADFSLEKHQMALDYAAGRCAFTVMTDSLLDQLQNAPADVQKTSA NTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRREGAEVT FVELAERPTIEEWQNLLTTRSQQVLPNADYL" aSDomain 7028..7204 /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_7_PP-binding.1" /evalue="4.40E-12" /label="ctg21_7_PP-binding.1" /locus_tag="ctg21_7" /protein_end="293" /protein_start="234" /score="38.3" /tool="antismash" /translation="IRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRREGAE VTFVELAERPTIEE" CDS 7284..14420 /NRPS_PKS="Domain: Condensation_Starter (7-301). E-value: 1.2e-121. Score: 397.5. Matches aSDomain: nrpspksdomains_ctg21_8_Condensation_Starter.1" /NRPS_PKS="Domain: AMP-binding (463-861). E-value: 6.1e-117. Score: 382.5. Matches aSDomain: nrpspksdomains_ctg21_8_AMP-binding.1" /NRPS_PKS="Domain: PCP (966-1033). E-value: 9.1e-28. Score: 88.2. Matches aSDomain: nrpspksdomains_ctg21_8_PCP.1" /NRPS_PKS="Domain: Condensation_LCL (1048-1349). E-value: 4.8e-114. Score: 372.2. Matches aSDomain: nrpspksdomains_ctg21_8_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (1519-1935). E-value: 1.2e-117. Score: 384.8. Matches aSDomain: nrpspksdomains_ctg21_8_AMP-binding.2" /NRPS_PKS="Domain: PCP (2041-2108). E-value: 3.2e-28. Score: 89.6. Matches aSDomain: nrpspksdomains_ctg21_8_PCP.2" /NRPS_PKS="Domain: Thioesterase (2128-2358). E-value: 1.2e-37. Score: 122.3. Matches aSDomain: nrpspksdomains_ctg21_8_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRP-metallophore: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRP-metallophore: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 375.3; E-value: 8.3e-114)" /gene_kind="biosynthetic" /locus_tag="ctg21_8" /sec_met_domain="AMP-binding (E-value: 3e-127, bitscore: 417.2, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 3.9e-69, bitscore: 225.6, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 7.1e-16, bitscore: 51.2, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-08, bitscore: 28.3, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPINI ALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALNWM KADLAKPVDLGYDPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYTALI KGQTAKGRSFGSLQAILEENTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPRTSNS FLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPMMGRIG SASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRRDLKLIG ENHRLFGPQINLMPFDYGLDFAGARGTTHNLSAGPVDDLSINVYDRTDGSGLRIDVDAN PEVYSDPDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNETAKSEKLV SLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPEQFVALALPR SPEMVASMLGVLKTGAAYLPLDPEFPSDRISYMLEDAKPSCIITTEEIAASLPDNLAVP ELVLDQAVTQEIIKRYSPENPDVSVSLDHPAYIIYTSGSTGRPKGVVVTQKSLSNFLLS MQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIREPQALAQMIENF DINIMQATSTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQALQDLHCSVTNLYGPTET TIWSAAAFLEEGLQGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGELYIAGTGLARGYFH RPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADHQIKIRGFRIELGEID AVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRRYMGASLPDYMVPAAFV EMDELPLTPNGKLDRNALPAPDFSTSVSDRAPRTPQEEILCDLFAEVLGLARVGIDDSF FELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAAHLDLVQSARPALQRAERP EKIPLSFAQRRLWFLYCLEGPSPTYNIPVTVRLSGELDQGLLKAALYDLVCRHESLRTI FPESQGTSYQHILDADQACPELHVTEIAEKELSDRLAEAVRYNFDLAAEPAFRAELFVI GPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHGRSPEWAPLAVQYADYALWQQE LLGNEDNPNSLIAGQLAFWKETLKNLPDQLELPTDYSRPAEPSHDGDMIHFRIEPEFHK RLQELARTNRVSLFMVLQSGLAALLTRLGAGTDIPIGSPIAGRNDDALGDLVGLFINTL VLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFERLVEVLNPARSRATHPLFQIMLAF QNTPDAELHLPDMESSLRINSVGSAKFDLTLEISEDRLADGTPNGMEGLLEYSTDLFKR ETAQALADRLMRLLEAAESDPDEQIGNLDILAPEERSSMVADWQSVSEKIPHACLPEQF EKQAALRPKAIAVVYEDQALSYAELNERANRLARMLISEGVGPEQFVALALPRSLEMAV GLLAVLKAGAAYLPLDPDYPADRIAFMLKDAQPAFIMTNTKAANHIPPVENVPKIVLDD PELAEKLNTYPAENPKNKDRTQPLSPLNTAYVIYTSGSTGVPKGVMIPHQNVTRLFAAT EHWFRFSSGDIWTMFHSYAFDFSVWEIWGPLLHGGRLVIVPHHVSRSPEAFLRLLVKEG VTVLNQTPSAFYQFMQAEREQPDLGQALSLRYVIFGGEALELSRLEDWYNRHPENRPQL INMYGITETTVHVSYIELDRSMAALRANSLIGCGIPDLGVYVLDERLQPVPPGVAGELY VSGAGLARGYLGRPGLTSERFIADPFGPPGTRMYRTGDVARLRADGSLDYVGRADHQVK IRGFRIELGEIEAALVQHPQLEDAAVIVREDQPGDKRLAAYVIPSEETFDTAELRRYAA ERLPDYMVPAAFVTMKELPLTPNGKLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFME VLHLPRVGIDDRFFDLGGHSLLAVQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMG SSQSALDVLLPLRTSGDKPPLFCVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQRE ELPKTLDDMAADYIKQIRTVQPKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLD AYPNHFLPIKEAPDDEEALIALLALGGYDPDSLGDKPLDFEAAIEILRRDGSALASLDE TVILNLKNTYVNSVGILGSYKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQ IDIDCRHKDLCQPEPLAQIGKVLAVKLEELNK" aSDomain 7305..8186 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_8_Condensation_Starter.1" /domain_subtypes="Condensation_Starter" /evalue="1.20E-121" /label="ctg21_8_Condensation_Starter.1" /locus_tag="ctg21_8" /protein_end="301" /protein_start="7" /score="397.5" /tool="antismash" /translation="QYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPINIALFEEAL RHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALNWMKADLAKP VDLGYDPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYTALIKGQTAKG RSFGSLQAILEENTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPRTSNSFLRHTAY LPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPMMGRIGSASLNVP AMVMNLLPLRLTV" aSModule 7305..10382 /complete /domains="nrpspksdomains_ctg21_8_Condensation_Starter.1" /domains="nrpspksdomains_ctg21_8_AMP-binding.1" /domains="nrpspksdomains_ctg21_8_PCP.1" /locus_tags="ctg21_8" /monomer_pairings="Gly -> Gly" /starter_module /tool="antismash" /type="nrps" CDS_motif 7308..7349 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0001" /evalue="3.70E-03" /label="C1_starter_004-017" /locus_tag="ctg21_8" /protein_end="22" /protein_start="8" /score="10.2" /tool="antismash" /translation="YSLTGAQTGIWFAQ" CDS_motif 7368..7487 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0002" /evalue="4.00E-20" /label="C2_starter_024-063" /locus_tag="ctg21_8" /protein_end="68" /protein_start="28" /score="64.4" /tool="antismash" /translation="PIYNTAEYIEINGPINIALFEEALRHVIKEAESLHVRFGE" CDS_motif 7695..7760 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0003" /evalue="7.10E-10" /label="C3_starter_134-155" /locus_tag="ctg21_8" /protein_end="159" /protein_start="137" /score="31.6" /tool="antismash" /translation="IHHIAIDGFGFSLIAQRVASTY" CDS_motif 8088..8177 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0004" /evalue="4.20E-13" /label="C5_starter_265-294" /locus_tag="ctg21_8" /protein_end="298" /protein_start="268" /score="41.6" /tool="antismash" /translation="DVVLGLPMMGRIGSASLNVPAMVMNLLPLR" CDS_motif 8226..8339 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0005" /evalue="5.00E-17" /label="C67_starter_14fromHMM" /locus_tag="ctg21_8" /protein_end="352" /protein_start="314" /score="54.3" /tool="antismash" /translation="SREIRSIRRHHKYRHEELRRDLKLIGENHRLFGPQINL" aSDomain 8673..9866 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_8_AMP-binding.1" /evalue="6.10E-117" /label="ctg21_8_AMP-binding.1" /locus_tag="ctg21_8" /protein_end="861" /protein_start="463" /score="382.5" /specificity="substrate consensus: Gly" /tool="antismash" /translation="FEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPSDRISYMLEDAKPSCIITTEEIAA SLPDNLAVPELVLDQAVTQEIIKRYSPENPDVSVSLDHPAYIIYTSGSTGRPKGVVVTQ KSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIREPQ ALAQMIENFDINIMQATSTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQALQDLHCSV TNLYGPTETTIWSAAAFLEEGLQGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGELYIAG TGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADHQIKIR" CDS_motif 8859..8900 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0006" /evalue="8.60E-05" /label="NRPS-A_a2" /locus_tag="ctg21_8" /protein_end="539" /protein_start="525" /score="15.8" /tool="antismash" /translation="LGVLKTGAAYLPLD" CDS_motif 9102..9158 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0007" /evalue="8.10E-10" /label="NRPS-A_a3" /locus_tag="ctg21_8" /protein_end="625" /protein_start="606" /score="30.6" /tool="antismash" /translation="AYIIYTSGSTGRPKGVVVT" CDS_motif 9525..9548 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0008" /evalue="7.60E-02" /label="NRPS-A_a5" /locus_tag="ctg21_8" /protein_end="755" /protein_start="747" /score="6.3" /tool="antismash" /translation="YGPTETTI" CDS_motif 9657..9746 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0009" /evalue="7.10E-18" /label="NRPS-A_a6" /locus_tag="ctg21_8" /protein_end="821" /protein_start="791" /score="56.6" /tool="antismash" /translation="PPGVVGELYIAGTGLARGYFHRPDLTAERF" CDS_motif 9831..9893 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0010" /evalue="1.90E-11" /label="NRPS-A_a8" /locus_tag="ctg21_8" /protein_end="870" /protein_start="849" /score="35.9" /tool="antismash" /translation="YIGRADHQIKIRGFRIELGEI" CDS_motif 10104..10130 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0011" /evalue="6.00E-01" /label="NRPS-A_a10" /locus_tag="ctg21_8" /protein_end="949" /protein_start="940" /score="3.6" /tool="antismash" /translation="GKLDRNALP" aSDomain 10182..10382 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_8_PCP.1" /evalue="9.10E-28" /label="ctg21_8_PCP.1" /locus_tag="ctg21_8" /protein_end="1033" /protein_start="966" /score="88.2" /tool="antismash" /translation="EEILCDLFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMG AELGIAKLFDEPTVAGLAAHLD" aSDomain 10428..11330 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_8_Condensation_LCL.1" /domain_subtypes="Condensation_LCL" /evalue="4.80E-114" /label="ctg21_8_Condensation_LCL.1" /locus_tag="ctg21_8" /protein_end="1349" /protein_start="1048" /score="372.2" /tool="antismash" /translation="EKIPLSFAQRRLWFLYCLEGPSPTYNIPVTVRLSGELDQGLLKAA LYDLVCRHESLRTIFPESQGTSYQHILDADQACPELHVTEIAEKELSDRLAEAVRYNFD LAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHGRSPEWAP LAVQYADYALWQQELLGNEDNPNSLIAGQLAFWKETLKNLPDQLELPTDYSRPAEPSHD GDMIHFRIEPEFHKRLQELARTNRVSLFMVLQSGLAALLTRLGAGTDIPIGSPIAGRND DALGDLVGLFINTLVLRTDT" aSModule 10428..14357 /complete /domains="nrpspksdomains_ctg21_8_Condensation_LCL.1" /domains="nrpspksdomains_ctg21_8_AMP-binding.2" /domains="nrpspksdomains_ctg21_8_PCP.2" /domains="nrpspksdomains_ctg21_8_Thioesterase.1" /final_module /locus_tags="ctg21_8" /monomer_pairings="Thr -> Thr" /tool="antismash" /type="nrps" CDS_motif 10443..10472 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0012" /evalue="1.60E-02" /label="C1_LCL_004-017" /locus_tag="ctg21_8" /protein_end="1063" /protein_start="1053" /score="8.1" /tool="antismash" /translation="SFAQRRLWFL" CDS_motif 10494..10610 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0013" /evalue="6.30E-13" /label="C2_LCL_024-062" /locus_tag="ctg21_8" /protein_end="1109" /protein_start="1070" /score="41.1" /tool="antismash" /translation="PTYNIPVTVRLSGELDQGLLKAALYDLVCRHESLRTIFP" CDS_motif 10812..10877 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0014" /evalue="7.90E-10" /label="C3_LCL_132-143" /locus_tag="ctg21_8" /protein_end="1198" /protein_start="1176" /score="31.2" /tool="antismash" /translation="VHHIVGDGWSLTPLTRDLGTAY" CDS_motif 10926..10964 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0015" /evalue="3.90E-05" /label="C4_LCL_164-176" /locus_tag="ctg21_8" /protein_end="1227" /protein_start="1214" /score="16.2" /tool="antismash" /translation="QYADYALWQQELL" CDS_motif 11232..11321 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0016" /evalue="1.40E-13" /label="C5_LCL_267-296" /locus_tag="ctg21_8" /protein_end="1346" /protein_start="1316" /score="43.1" /tool="antismash" /translation="DIPIGSPIAGRNDDALGDLVGLFINTLVLR" CDS_motif 11370..11489 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0017" /evalue="4.40E-20" /label="C67_LCL_14fromHMM" /locus_tag="ctg21_8" /protein_end="1402" /protein_start="1362" /score="64.1" /tool="antismash" /translation="REVNLAAYDNQDLPFERLVEVLNPARSRATHPLFQIMLAF" aSDomain 11841..13088 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_8_AMP-binding.2" /evalue="1.20E-117" /label="ctg21_8_AMP-binding.2" /locus_tag="ctg21_8" /protein_end="1935" /protein_start="1519" /score="384.8" /specificity="substrate consensus: Thr" /tool="antismash" /translation="FEKQAALRPKAIAVVYEDQALSYAELNERANRLARMLISEGVGPE QFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDAQPAFIMTNTKAAN HIPPVENVPKIVLDDPELAEKLNTYPAENPKNKDRTQPLSPLNTAYVIYTSGSTGVPKG VMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWGPLLHGGRLVIVPHHV SRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQALSLRYVIFGGEALELSR LEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRANSLIGCGIPDLGVYVLD ERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPFGPPGTRMYRTGDVARLRA DGSLDYVGRADHQVKIR" CDS_motif 12027..12068 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0018" /evalue="1.30E-05" /label="NRPS-A_a2" /locus_tag="ctg21_8" /protein_end="1595" /protein_start="1581" /score="18.3" /tool="antismash" /translation="LAVLKAGAAYLPLD" CDS_motif 12285..12344 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0019" /evalue="1.40E-10" /label="NRPS-A_a3" /locus_tag="ctg21_8" /protein_end="1687" /protein_start="1667" /score="33.0" /tool="antismash" /translation="AYVIYTSGSTGVPKGVMIPH" CDS_motif 12738..12761 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0020" /evalue="2.30E+00" /label="NRPS-A_a5" /locus_tag="ctg21_8" /protein_end="1826" /protein_start="1818" /score="2.1" /tool="antismash" /translation="YGITETTV" CDS_motif 12879..12968 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0021" /evalue="1.40E-16" /label="NRPS-A_a6" /locus_tag="ctg21_8" /protein_end="1895" /protein_start="1865" /score="52.5" /tool="antismash" /translation="PPGVAGELYVSGAGLARGYLGRPGLTSERF" CDS_motif 13053..13118 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0022" /evalue="1.30E-12" /label="NRPS-A_a8" /locus_tag="ctg21_8" /protein_end="1945" /protein_start="1923" /score="39.5" /tool="antismash" /translation="YVGRADHQVKIRGFRIELGEIE" CDS_motif 13329..13355 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0023" /evalue="2.00E-01" /label="NRPS-A_a10" /locus_tag="ctg21_8" /protein_end="2024" /protein_start="2015" /score="4.9" /tool="antismash" /translation="GKLDRKALP" aSDomain 13407..13607 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_8_PCP.2" /evalue="3.20E-28" /label="ctg21_8_PCP.2" /locus_tag="ctg21_8" /protein_end="2108" /protein_start="2041" /score="89.6" /tool="antismash" /translation="EEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLAVQLMSRIREALG VELSIGNLFEAPTVAGLAERLE" aSDomain 13668..14357 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg21_8_Thioesterase.1" /evalue="1.20E-37" /label="ctg21_8_Thioesterase.1" /locus_tag="ctg21_8" /protein_end="2358" /protein_start="2128" /score="122.3" /tool="antismash" /translation="PPLFCVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPK TLDDMAADYIKQIRTVQPKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPN HFLPIKEAPDDEEALIALLALGGYDPDSLGDKPLDFEAAIEILRRDGSALASLDETVIL NLKNTYVNSVGILGSYKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDID CRHKDLCQ" CDS_motif 13671..13700 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0024" /evalue="1.40E-03" /label="NRPS-beforete1" /locus_tag="ctg21_8" /protein_end="2139" /protein_start="2129" /score="11.6" /tool="antismash" /translation="PLFCVHPAGG" CDS_motif 13851..13925 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg21_8_0025" /evalue="1.40E-13" /label="NRPS-te1" /locus_tag="ctg21_8" /protein_end="2214" /protein_start="2189" /score="43.1" /tool="antismash" /translation="QPKGPYHLLGWSLGGNVVQAMATQL" CDS 14436..14645 /gene_functions="biosynthetic-additional (smcogs) SMCOG1009:mbtH-like protein (Score: 107.4; E-value: 3.7e-33)" /gene_kind="biosynthetic-additional" /locus_tag="ctg21_9" /transl_table=11 /translation="MANPFENADGTYLVLINEEGQYSLWPGFIDVPSGWTVVHEQKGRE ACLDYIQSHWSDMRPNSLKTVENV" CDS complement(14689..15366) /locus_tag="ctg21_10" /transl_table=11 /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAINV MSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREMKP LPHEITGPDNDLNDFIETYMKKAQDEKAPVYIFGSKFGPEQAADKIFGFTPTNGMHNIH MNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDCDHTQ TSA" CDS complement(15478..16614) /gene_functions="biosynthetic-additional (rule-based-clusters) 2-Hacid_dh_C" /gene_kind="biosynthetic-additional" /locus_tag="ctg21_11" /sec_met_domain="2-Hacid_dh_C (E-value: 2e-10, bitscore: 32.9, seeds: 135, tool: rule-based-clusters)" /transl_table=11 /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSGF ENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPELAQ ALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAGVPG VSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLISNPVN IADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETVDHITT HDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALADNAALRA GLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA" CDS complement(16716..17984) /locus_tag="ctg21_12" /transl_table=11 /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPITI EDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVKQI DEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQIRKT KNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIEQQLQ YLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIEDVSIA FGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEKRKQAGH YNYSLSKLEQYDRDHQSNLVETLERFIEADSNVNTASKLLNIHVNTLNYRLKRISQIAE IDLKNVNQKFTIYLDIKLRHMDL" CDS 18506..18799 /locus_tag="ctg21_13" /transl_table=11 /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMWE GASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG" CDS 18869..19108 /locus_tag="ctg21_14" /transl_table=11 /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPPR EGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL" CDS 19123..20478 /locus_tag="ctg21_15" /transl_table=11 /translation="MSGKQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVIK DINPFFYKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNLSR LNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFAFED YLKFNETLTFSAEAKAILDTESYDDLLELIQIHIDELEAKAKTYIHIPRKKWNIQRYIG LGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYEAESLPESV QYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISIGRKLEY NDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSETSLVDTS EEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKKKEDEKKETEKKDEKKDDK" CDS 20506..25026 /locus_tag="ctg21_16" /transl_table=11 /translation="MLPFGRKGVRHLSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKD SVTISSIPFNSGVVSLKRKESGGQYEVFLGNDCLGTIEADTSFTLQTDQQDIRLILTGS EPEKSVYFTGNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTI FLNGEKINANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKK YPQYRRTPRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRG IFILVSLAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQ VLEFHFPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANR DIDDLMEKSQHMQRVYKDIRHAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSY HDLRFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDL EDDKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITT LVRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAGT TGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGSKN FSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAELKS EEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATDSKEI LKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDTGLIPL SEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLADRIPRTLFPSNEKD HFHFAYVDEPDLQRQAPIVYKMMEDGNIGIFGSSGYGKSITAATFLMSFADVYTPEELH VYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFREKEISHIK MYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFMLTATRVNAVR QSLLNNLKTKVVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFAQMFLPVDADD DIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTREFSLRFKLERKPLSVPIGLHE ETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGLFDSIDRGLSHYA KESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRFSQVVLMIDGITRF QQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTEMKQIRHAILLMKKS EQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESAR" CDS 25023..28202 /locus_tag="ctg21_17" /transl_table=11 /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQIA VVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKYDA IVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKMSAL YWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDELKKSM NEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIRTGLDA IQAQQKANQFSERMSGLATGIGQAKTQLGLTSLALKSAEQTRQGQVPLQEMGMKKIQED MFSTFLERYETQYTATKIQNLNQLQDKIVNLRPALIKPEEDDQKHDNSNEENNDKEEDT TEEIKLDLEQQRDELNNVAAEIKDISEGLKEPELNNPTMPGSEDPTNDDNTNNKNPTSG DQPTDGNDGSTDDSTQMNPEINNEADNQGQQNSSEKTNDLNGKTETTAQSKAALRIIQL ADENDGSQVDDSKNESDISIAKKRLNAAAEQIQKIEEELKEKQEEHNSKVEKRIEKLDK EIKDLNDKVDSLNIKINDLTSKFNDINDQFNKSSLLISEKEKEILKILRNNGEKDRLEQ LSSVFTNTVDTKNVSDLMKYYNYLYLYEKTLTGSLDVGSMSLLSRDAIQGQQGNVKSVL ALTPEESASWEALKNNTMQTDEDINSFIDGMTKFADDYSGYIRDSQAGVLDELTKISES AAKTSEQLVTGATQESATFSNDGLSGTMALSVQDTVGQEVLQMSDMMGSLSDRQSGIID YTTNMQQSVNDVQAKADTLNNNWGKNVASTKLVRNDVYGILGNTLVDGQNNGYVYDYLA NPLKISGEVPEEKIQTVPPVVILVIVLISSLLIGYFSSYYQNAPLLVKGALFGILNILV GLMISLFGLNIYSLPDDQTIKWSVFTILLLVASSAFIRTAFRFGSIPGWVASAAMILFY VAPLIDLIMPNFTFEDPVSKVYIDIQYGTGHLFTMGITVLLIITVIAAALPLIIRLMAE HTAESDETYEA" CDS 28183..28689 /locus_tag="ctg21_18" /transl_table=11 /translation="MKRMKRDRSMEKGIMICMLSFSLFIPSAAAAQTEENTDVAPNQYE KKDIEIDTNYLHEDTYYEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIA AQSKQLGITFAEKPITKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQ ENKKA" CDS 28752..29483 /gene_functions="biosynthetic-additional (smcogs) SMCOG1001:short-chain dehydrogenase/reductase SDR (Score: 109.6; E-value: 3.1e-33)" /gene_kind="biosynthetic-additional" /locus_tag="ctg21_19" /transl_table=11 /translation="MELYIITGASKGLGQAVALQALEKGHEVHALSRTKTDVSHEKLTQ HQIDFINLEEAEQQFETLLSSIDPERYSGITLINNAGMVTPIKRAGEASLDELQRHYQL NLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRTFGF EQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDFIAGT LLSLLEKGTENGRIYDIKEFL" CDS 29681..30211 /locus_tag="ctg21_20" /transl_table=11 /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADINP DLAVKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAKEI ALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEKLDQ LIDQAQASVIKPV" CDS 30388..30624 /locus_tag="ctg21_21" /transl_table=11 /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLIDV KPDHITIEGARNSVCLIRIQHMISVIPDYSERV" CDS complement(30665..31054) /locus_tag="ctg21_22" /transl_table=11 /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQDG KIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYGVTFCFSDGD YQEFAGFDLDGTMYHSAFLQRLTEK" CDS 31172..32278 /locus_tag="ctg21_23" /transl_table=11 /translation="MKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPMLI AGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITSQVTGLFNNLP DYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAVFGVV TNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAYFQGQL LICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFMDSPAKA LFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMILAVPVYAV VKAFFLNIVRLIKLRQRSRLEENAKPAE" CDS 32338..32559 /locus_tag="ctg21_24" /transl_table=11 /translation="MPAIVGPIYIMSVTGNAAASFGDIFAISPKSVAHSGAGSGAFQLG DFVKINNQTSKTLFEDADITDETVSFNG" CDS 32632..32880 /locus_tag="ctg21_25" /transl_table=11 /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISYE EDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM" CDS 32952..33350 /locus_tag="ctg21_26" /transl_table=11 /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQV LRSKPYKEAEHELKNSHNVTLLVNGELQYQSYSPYIQMANRYGVPFKIVSDLQFHTPLG LVIAADIAVNRELIYIQDDIYNRSVLKS" CDS 33447..33998 /gene_functions="biosynthetic-additional (smcogs) SMCOG1027:isochorismatase (Score: 79.2; E-value: 4.8e-24)" /gene_kind="biosynthetic-additional" /locus_tag="ctg21_27" /transl_table=11 /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTEEFITNG DYVVLAVDSHAEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYMEKT RYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVASFNQ EGHAWALSHFANSIGAQVAE" ORIGIN 1 cgttttctct acaagctgag gctccccttt actggggagc cttttctcgt tatgataaaa 61 aaaccgtcca atagaacggc tttacatgga cgatatgtga tttctgttaa agccggttgc 121 tttatgaatc gagcggtaga ttgctggtgc gataaacgac agtatcacag ccagcgctgt 181 atcttttgcc ataaaccaaa tcataaagcc ccaagccgtg ccgtagctca ctggcgtatg 241 aatccacagc ttcagtgcaa gatacatata ggtagtgccg atgagataca tgatcgccgt 301 tccgataagt gaagcaatga gaaatcgaat tttacttggc tgaatgtttc gttctaaaaa 361 ccaccccgct acaaatgctg ccgggatgta tgagataata aatccgccgc ttttccctgc 421 aaacggtgcg aagcctgctg aaaattgagc aaacacaggc gctccggcca atccgacaag 481 tgcatataca atcatggcaa tcgctgctcg tttgctgcca agaagcaaag ctgccaagag 541 acagaaaaac ggctgcatcg aaagcggaat gccggctact tgtaaaaagg gtgctactga 601 tgtaatgttg gccccgacag ccataagtgc ggcgaacatg ccaatcagcg ccatatctcc 661 cgcacgaagt ttacgttgtt tcatcgttgt tcccccttag gttgacatac acaatcatag 721 agtaataaag aacaaaaaga ttgtcaacat gattttaaat taggttaaca aaaagggggg 781 ctccatatgt atttcggaaa aacaagacag tccgatcaat ctggaagagt gccgccaaat 841 caaaacgtca ccacttcatt tcctgtgctt cataccggaa atgtcccata ttacgaagat 901 atgacgaaat ggaatcttca agtatacggt ttggttgacc atccgatgct gctaagcttt 961 gaagatgtca aagcctttcc acggtatgaa tcgaaaaacg acattcattg cgtcacggga 1021 tggtcaaggc ttgataatgt gtggcaaggc gtgcgggctt gtgatatagc ggaaaaagcg 1081 ggtgtaaaag aagaagcggg ctacgtcatt ttacatgctg aagagggctg gacgaccaat 1141 ctgccgcttg atgatttctt agcggaaact tcccttctgg cttatgcgca taatggcgaa 1201 cctttacccc cagaacacgg ctttccgctg cggggggtat ttccgcatct gtatttttgg 1261 aaaagcgcca agtggctgcg cggcatccaa tttacgaaag aaaatcaccc tggcttttgg 1321 gagcggaatg gctatcagag gcgatccgtg gaaaaatcaa agatttacat gggattaagg 1381 ttctatttca aataggacaa tccgcatttt tattgggttt ttacttccat attgatagtc 1441 tgcaggtacc ttatttgatc aaggtgcctt ttttattcgg gaaaaagttg actttctttg 1501 gaagaaaacc tattatttga ggtgtctagt tgatagtgaa aatcattatc atacattgcg 1561 gtttagttta aggagaggaa tgtcgtactg catgaaagag caaacaacag accggacaaa 1621 tggcgggaca tcaaacgcat ttacgattcc tggtacggaa gtgcgtatga tgtcttcacg 1681 caatgaaaac cgtacctatc acatttttat ctcgaaacct agtacgccgc cgccacccgc 1741 tggttatcct gtgatttatc tgctggatgc caattctgtc ttcggaacga tgacggaagc 1801 cgttcgaata cagggacgcc gccccgaaaa aaccggggtg atccctgcag tgatcgtcgg 1861 cattggctat gagacagcgg agccgttctc ttcagcacgc caccgggatt ttacaatgcc 1921 aacagcccaa tcgaagctgc cggaaaggcc cgacggcaga gaatggccgg agcatggcgg 1981 agcggagggc tttttcagat ttattgaaga ggatttaaaa ccggagatag aacgagatta 2041 ccagattgat aaaaaaagac aaacaatctt tggccattcg ctcggagggc ttttcgtgct 2101 gcaggtgctg ctaacaaagc ccgatgcgtt tcaaacgtat atcgcaggaa gtccgtccat 2161 tcattggaat aaaccgttta ttctcgagaa aacggaccat ttcgtctctc tcaccaagaa 2221 aaacaatcag cctatcaata tccttcttgc cgcaggagaa ttagagcagc atcataaaag 2281 ccggatgaat gataatgcaa gggagcttta tgagcggctg gccattttat ctgaacaagg 2341 catacgagca gaattttgcg agttctcagg agaaggacat atttcagttc ttcctgtttt 2401 ggtcagccgg gcgctgcgtt ttgcgcttca ccctgacgga ccgcatctat caatgggctg 2461 agacatactc agccttgcct ttaaaaaaat atttgtcact gaaattatat ttgactgtca 2521 catgacattt ggatatgatt atttttataa ttgataatga taatcattat caatagattg 2581 cgtttttaag gcgcagcagt ctttttcgct ggatgtctgt tcggcattta gagcgaagaa 2641 aggaattgat gatatgaatg caaagggtat agagggaaaa attgctttta taacaggggc 2701 tgcccaagga ataggcgaag ctgttgcgcg gacgcttgcc agtcaaggcg cacatattgc 2761 ggcagttgat tataatcctg aaaagctgga aaaggttgtg agcagcctca aagcagaagg 2821 ccgccatgca gaagcttttc ctgcggatgt gagagacagc gcggcgattg atgagatcac 2881 ggcgcgcatc gaacgtgaaa ttgggccgat tgatatttta gtgaatgtag cgggtgtcct 2941 tcgcccggga ctgatccatt cgcttagcga tgaggaatgg gaggcgacgt tctcagtgaa 3001 ttcgactggc gtatttaacg tctcgcgttc agtcagcaaa tatatgatgg accgaagatc 3061 gggttcgatt gtaacagtcg gatcgaatgc tgccggtgta ccaagaacat ctatggcggc 3121 atatgcgtct tcaaaggctg cggctgtgat gtttacgaaa tgccttggcc ttgagcttgc 3181 agaatacaat attcgctgca acattgtatc tcccggatca acggaaacag acatgcagtg 3241 gtcattatgg gccgacgaga atggagcgga gcaagtcatc aaaggatcac ttgagacatt 3301 taaaacaggg attccgctca aaaaactagc caagccttcg gatattgcgg atgcggtgct 3361 ctttttggtt tctggccagg cagggcatat tacgatgcat aatttatgcg tagatggcgg 3421 cgcgacctta ggcgtgtaac tgaatttaaa ggaggttcat gagaatgttg gatcaaaacg 3481 ttataacaga aacaaaagcg gagcatttgc ttcatgaata tcagccgggc gcctttttct 3541 tagcgtctcc tcatcgtgta ttgttagcga aaggcatatg tgaaatcgta ccggaggcag 3601 acgggcaaaa ccaaatggaa accctttctg gccgaattgc agagacgctg cgtcaggcaa 3661 aacaatcagg gcaaagccgg ccgcttgttg tcggggccgt tccttttgat caagtaaaac 3721 cagcgcggct cgttgtacct gaagaagtgc gctggtcagg accgcttcaa tttgatcatg 3781 aggaaaagga acagcaggct gggcatacat accacataaa gcctgttcct gaacctgagg 3841 attataaaaa tggtgttgaa caagggctga cacgcattgc cgatggaaca ctcagcaaaa 3901 tcgtcctgtc cagatcgctg catttgacat cgcctgaacc gattcagacg gatgaattgc 3961 ttcgccatct ggctcagcat aacacgcatg gctacacgtt tgccgcagac gtgtccagcc 4021 aggaggaaac gtctccccgc cgaacattgc tcggagcaag tccggagctt ctcgtttcaa 4081 ggatgggaac acaggtcgtt tccaacccat tagccggctc aaggccgcgc agtaatgatc 4141 ctgttgaaga ccagcgccgg gcagctgaat tgctttcttc cgcaaaggat cttcatgagc 4201 acgcggttgt cgctgacgcg gttgcggcag cgctgagacc tttctgccgg acgctggagg 4261 ttccagagaa gccttcactg atcaaaacgg aaacgatgtg gcacctgtcc agcgtgatta 4321 agggagagct ttccgacccg tctgtaaccg cacttgaatt ggcggcggcg ctccacccga 4381 cgccagcagt ctgcggaaca ccgactgatc ttgcaagaga agcgattctc agcattgaac 4441 catttgaccg cggtttcttt accggtatgg tcggatggtg tgacgatgcc ggtgacggag 4501 aatggatcgt gaccatccgt tgtgcagaag cagaagaacg ctcactccgc ctgtatgctg 4561 gagctggtgt tgtggccggt tcaaagcctg aggacgagct tcaggaaacg tccgcaaagt 4621 ttcggacaat gctgcgggca atgggcgtgg atcacatatg aacagggagg gatgcaacat 4681 gctgaaagga tttacgcctt ggcctgatga gttagctgag acctatcgaa agaacggctg 4741 ctgggccggt gagacgtttg gagatttgtt aagggaccgg gcagccaaat atggcgaccg 4801 cattgcgatt acatgcggaa acacccattg gagctatcaa gagcttgaca caagggttga 4861 tcgtttggct gccggatttc agaagctcgg cattcaacag atggatcgtg tcgtggtgca 4921 gctgccaaat atcaaagagt tttttgaagt cattttcgcg cttttccgtc tgggggcgct 4981 tccagtcttc gcactgcctt ctcatcgaag cagtgaaatt acatattttt gcgagtttgc 5041 tgaagcggct gcatatatca ttcccgacgc ttattccggt tttgactatc gtacgcttgc 5101 cagacaggtt caaagcaagt tgccgacttt gaaaaacatc attgtcgcag gtgaggcaga 5161 ggaatttttg ccgctcgagg atttgcatac agaacctgta aaactgcctg aagtcaaatc 5221 ttcggatgtg gcgttcctcc agctttctgg cgggagcacc gggctatcga aactgattcc 5281 gaggacccac gatgactaca tatacagcct gaagcggagt gtggaggtct gctggctcga 5341 ccacagcacg gtgtacttgg ccgcgctgcc gatggcacat aattatccgc tgagctcacc 5401 tggcgttctc ggcgtattat acgctggagg aagagtggta ttatctcctt ctccaagtcc 5461 agatgacgca tttcctttaa ttgaacggga aaaggtcacg ataaccgctc ttgttccgcc 5521 tcttgcgatg gtatggatgg atgcggcatc ctcacgccgt gatgatttat ccagtcttca 5581 agtgctgcag gtcggcggtg ccaagtttag tgctgaagcc gcgcgcaggg taaaagctgt 5641 tttcggctgc acgctgcagc aggtattcgg aatggcagag ggtctcgtca attatacgag 5701 attggatgat cctgaggaga tcattgtcaa cacccaagga aaaccgatgt ccccatatga 5761 tgaagtgcgt gtttgggatg atcaggatcg cgacgtaaaa cctggtgaaa caggccatct 5821 gctgacgcgg ggaccgtata caattcgagg ttactataag gcagaagagc ataacgccgc 5881 ttcatttact gaggacggtt tttaccgtac gggtgatatc gtcaggctga cacgagacgg 5941 ctatattgtc gttgaaggcc gggcgaagga tcaaattaac cgtggaggag aaaaggttgc 6001 ggctgaagag gtagaaaatc atctgctggc gcatccggct gtccatgatg cggcaatggt 6061 ctccatgcct gatcaatttc ttggcgagag atcttgtgtg ttcattattc ccagagatga 6121 agccctaaaa gccgcagagc tcaaagcatt tttgagagag cgcggactgg cggcatataa 6181 aatccctgac cgagttgaat ttgtcgaatc cttcccgcag acaggggtag gaaaggtaag 6241 caaaaaggct cttcgtgaag ctatttccga aaaacttctt gcaggggcaa aaaaataaat 6301 caacaatttg agaggaagtg ttcatatggc tatacctgcc attcagccgt atcaaatgcc 6361 gacagcgtct gatatgccgc aaaacaaagt atcatgggtg cctgatccca accgggctgt 6421 cttgttaata cacgatatgc aaaactattt tgtcgatgct ttcacagcgg gagcgtctcc 6481 ggtaatagag ctttcagcga atatacgaaa gctgaagaat caatgtgttc agcttgggat 6541 tcctgttgtc tataccgcac agccgggaag ccaaaatccg gatgaccgtg cgctgctgac 6601 agacttttgg ggcccgggat taaacagcgg tccttatgag gagaaaatta taaccgagct 6661 ggcaccagag gatgatgatc ttgtgctgac aaaatggaga tacagcgcgt ttaagagaac 6721 gaatctgctt gaaatgatgc gcaaagaggg acgcgatcag ctgatcatta caggaattta 6781 cgcccatatc ggctgtcttg ttacagcatg cgaagcattt atggaagata ttaaagcctt 6841 ttttgtggga gatgcagttg ctgatttttc attagaaaaa catcaaatgg cgctggacta 6901 tgcggctgga cgctgtgcgt ttaccgtgat gactgacagt cttcttgatc agctgcagaa 6961 tgcgccggca gacgttcaaa aaacgtcagc aaacactggc aaaaagaacg tgtttacatg 7021 tgagaatatc cgtaaacaaa ttgctgagct tctacaagaa acaccggaag acatcacaga 7081 tcaagaggat ttgctcgatc gtggtcttga ttcggtaagg atcatgacat tggtggaaca 7141 atggcgccgt gaaggggcag aggtgacttt cgtggaattg gctgaacgcc caacgatcga 7201 agaatggcag aatttgctca caacccgcag ccagcaagtg ctgccaaacg cggattattt 7261 ataaaaggag ggtaaacaaa cggatgcctg atacaaaaga tcttcaatat tctttgaccg 7321 gggcgcaaac tggcatatgg tttgctcaac agcttgatcc ggacaatcca atttacaata 7381 ctgcggaata tatagaaatc aatggcccaa tcaatattgc tctttttgaa gaagctttgc 7441 ggcacgtgat caaggaagcg gaatcgctgc atgtccgctt cggtgaaaat atggacgggc 7501 cttggcagat gataaacccg tctccggatg tacagctgca cgtcattgac gtcagctctg 7561 agcctgatcc ggaaaaaaca gcattaaact ggatgaaagc tgatttagca aagccggttg 7621 atttagggta tgaccctttg ttcaatgaag ctctgtttat tgccgggcct gatcgtttct 7681 tttggtatca gcgcattcat catatagcga tcgacggctt tggtttttcc ctgatagccc 7741 agcgtgtggc aagtacatat actgcgctta taaaaggaca aacagctaaa ggccgttcct 7801 ttgggtctct ccaggccatt ttggaggaga atacagatta tcgcggatca gagcagtatg 7861 agaaggatcg tcaattctgg ctggaccgtt ttgcagatgc acctgaagtt gtaagcttgg 7921 ctgatcgtgc gccaagaaca tctaacagtt ttcttcgtca tacggcatat ctgcctccgt 7981 ctgatgtaaa cgcgttaaaa gaagcggcgc gctatttctc aggaagctgg catgaagtca 8041 tgattgcggt gtcagctgtt tatgtgcacc gtatgaccgg ctctgaggat gttgtactcg 8101 gcctgcccat gatgggtcga atagggtccg cgtcactgaa tgtaccggct atggtgatga 8161 accttctccc gctccggctg acggtaagct cttcgatgag cttttctgaa ctgattcagc 8221 aaatttcccg ggaaatccgc agtattcggc gacatcataa gtatcgccat gaagagcttc 8281 ggcgcgatct taaattgata ggagaaaatc atagattatt tggccctcaa atcaatctta 8341 tgccgtttga ttacggtctc gactttgccg gcgcccgggg cacaacgcat aatctttcag 8401 ccggtcctgt tgatgatcta tcaatcaatg tatatgacag aacagacggc agcgggctgc 8461 gaattgatgt tgatgcgaat cccgaggtat acagtgatcc tgatattaag cttcatcagc 8521 agcgtatcct gcagctgctg caaacggctt ctgccggaga ggacatgctg attgggcaaa 8581 tggagctcct attgccagag gagaaagaaa aagtcatttc taaatggaat gagacggcaa 8641 aatccgagaa gctggtcagc cttcaggaca tgttcgaaaa gcaggcagtt cttacgccag 8701 aacgtatcgc tctcatgtgt gatgacattc aagtcaacta tcgaaagctc aatgaagagg 8761 caaaccgcct cgcgcgtctg ttgatcgaaa aagggattgg tccggagcaa tttgtcgctt 8821 tggcgctgcc gcgttcccct gagatggtgg cctcaatgct tggtgtgctc aagactggtg 8881 cggcgtatct cccccttgat ccggagtttc catccgaccg catttcttac atgctggagg 8941 atgcgaaacc ttcatgcatc ataacgactg aggaaatagc agccagtctg cctgataacc 9001 tggctgtacc ggagcttgtg cttgatcagg ctgttacaca ggagattata aaacgctatt 9061 cgccggaaaa tccggatgta tcggtttcgc ttgaccatcc tgcgtatatc atctatacct 9121 caggatcaac aggaagaccg aagggagtcg ttgtgacaca gaaaagctta agcaattttc 9181 tgctgtccat gcaggaggca ttttctctag gagaagaaga caggctgttg gctgtgacga 9241 ctgtcgcttt tgatatttca gcattggagt tatatcttcc gctgattagc ggagcgcaaa 9301 ttgtgatcgc aaagaaagaa acgatccgtg agccgcaggc attagctcaa atgattgaaa 9361 atttcgatat taacatcatg caggcgacat cgacactgtg gcatgctttg gtaacgagtg 9421 aacctgagaa acttcggggg cttagagtgc ttgtaggagg cgaggcgctg ccgagcggtc 9481 ttttgcaggc gcttcaagac cttcattgtt cagtcacgaa tttatacggt cccactgaaa 9541 caacgatttg gtctgccgca gcttttcttg aagaagggct gcagggcgtt cctccgattg 9601 ggaaaccgat ttggaacacg caggtgtatg tgcttgataa tggattgcag ccggtgccgc 9661 cgggcgttgt cggagagctt tatattgcag gcaccggctt ggccagaggt tatttccatc 9721 gccctgattt aacggcggag cgcttcgttg cagatccata cggaccgccg ggaactcgga 9781 tgtatcggac cggagaccag gcccgctggc gtgccgatgg gtctttggat tatatcgggc 9841 gggcggatca tcaaatcaaa attcgcggat tccgaattga acttggagaa attgatgccg 9901 tgcttgccaa tcacccgcac attgaacagg ccgcggttgt cgtacgggaa gatcagccgg 9961 gagacaaacg attggcggct tatgtagtcg ctgatgctgc tattgatact gcagagcttc 10021 gtcgttatat gggggctagt cttcctgatt atatggtacc ggcggcgttt gtggagatgg 10081 acgagctgcc attaacacct aatggcaagc ttgaccggaa tgcactgccg gcaccagact 10141 tcagcacatc tgtcagtgat cgggccccgc ggactcctca ggaagagata ttgtgtgact 10201 tgtttgcaga ggttctcggt ttggcacgcg tcggtatcga tgacagtttc ttcgagcttg 10261 ggggccattc tcttcttgca gcccgtctga tgagccgcat tcgcgaggta atgggagccg 10321 aacttggtat cgccaagctc tttgacgaac caacagtagc cggactcgct gcccatcttg 10381 atttggtgca gagtgcacgt cccgctttgc agagagctga gcggcctgaa aagatcccgc 10441 tatcatttgc ccagcgccgg ctatggttcc tgtattgtct ggaaggaccg agtcctactt 10501 ataatattcc ggttactgtc cgtttgtcgg gtgagctgga tcaaggattg ctgaaagcgg 10561 cactttatga cctcgtctgc cgtcatgaaa gccttcggac gatcttccct gaatcacagg 10621 ggacatccta tcagcatatt ttagatgctg atcaagcctg tcccgaatta catgttactg 10681 aaattgctga gaaggagctt tctgatcggc ttgccgaagc tgtacgctac aactttgatc 10741 ttgcagctga acctgctttt cgtgccgagc tttttgtgat aggtcctgac gagtacgtgc 10801 tgcttcttct cgtacatcat attgtcgggg acggctggtc cttaacaccg ctgacccgag 10861 accttgggac ggcttatgcg gctcgctgcc acggacgatc tcccgaatgg gcgcctcttg 10921 ctgtgcagta tgcagactat gcgctttggc agcaagaact gcttggaaac gaggataatc 10981 caaacagctt gattgccggt cagcttgctt tctggaaaga aaccttgaaa aacctgcctg 11041 atcagcttga actgccaacc gattattcac gtccggctga gccgagtcat gatggagata 11101 tgattcattt tcgtattgag cccgagtttc acaagcgatt gcaggagctg gctcgcacaa 11161 atagggtgag cctgtttatg gtacttcaat ccggtctcgc cgctttattg acaaggctcg 11221 gggcgggcac cgacattccg atcggcagtc cgatcgcggg acggaatgat gatgcgctgg 11281 gcgatcttgt agggctgttc attaatacat tggtgctcag aactgatacg tccggtgacc 11341 caagctttcg tgagcttcta gacagagtac gggaagtgaa tctggccgcc tatgacaatc 11401 aggatctgcc gtttgagaga cttgtagagg tgctcaatcc ggctcgttcg cgtgcgacgc 11461 atcctttatt ccaaatcatg cttgcgttcc aaaacacacc ggacgctgaa ctgcatcttc 11521 ctgatatgga gagcagcctg cgaatcaaca gtgtcggttc tgctaagttt gatttgacgc 11581 tggaaattag tgaagatcgc cttgctgacg ggacaccaaa cggaatggaa ggactgcttg 11641 aatacagcac tgatcttttc aagcgggaaa ctgctcaggc tcttgctgac cgattgatgc 11701 gcctgttgga ggctgccgag tctgatcctg acgagcaaat cggaaatctg gatattcttg 11761 cgccagagga acgcagcagc atggtggctg attggcaaag tgtatctgaa aagattccgc 11821 acgcatgttt gccagagcaa tttgagaagc aggcagcttt acgtcctaaa gctattgccg 11881 ttgtatatga agatcaggca ctgagctatg cagagctgaa tgaaagagca aaccggcttg 11941 cccgaatgct gattagtgaa ggtgtcgggc cggagcaatt tgtggcattg gcactgcccc 12001 gatcgttgga aatggctgtc ggtctattgg cggtgctaaa ggccggggca gcttatctcc 12061 ctcttgatcc ggattatccg gctgatcgaa ttgcttttat gctaaaagat gcccagcctg 12121 cgtttatcat gacgaacact aaagctgcaa atcacattcc gccagttgaa aacgtgccga 12181 aaatcgtgct ggatgatccc gagctggcag agaaactaaa cacgtaccct gcagagaatc 12241 caaaaaataa ggacaggact cagccgcttt cgcctttgaa tacggcgtat gtcatttata 12301 catccggctc aacaggtgtt ccaaaaggtg tgatgattcc tcaccaaaat gtaacacgtt 12361 tatttgcagc gaccgagcac tggttccgtt tcagctcagg tgatatctgg accatgttcc 12421 attcctatgc gtttgatttt tcggtgtggg agatctgggg tcctctgctg catggcggac 12481 gtcttgtaat cgtgcctcac cacgtcagca gatcgccaga agcgtttctg cgcctgcttg 12541 tcaaagaggg ggtgactgtt ctgaaccaga caccgtctgc tttctatcag tttatgcagg 12601 cggaacggga acagccggat ctcggacagg cactcagtct gcgctatgtc atttttggcg 12661 gagaagcgct tgaactcagc cgtttagagg attggtacaa ccgccaccct gaaaatagac 12721 cgcagcttat caatatgtat ggtattacag aaacgacggt gcatgtgagc tatatcgaat 12781 tagaccgaag catggcagct ttacgggcaa acagcttgat cggctgcggc attcccgatc 12841 ttggtgtata cgtgctggat gaacgcctgc agccggtccc gccgggtgtt gccggagagc 12901 tgtatgtatc aggagcgggg ttagcacgag gttatctagg ccggcctggt ttaacatctg 12961 aacgcttcat agctgatccg ttcggtcctc caggcacccg gatgtaccgc actggggatg 13021 tggcccgcct ccgcgctgac ggttctctcg actatgtcgg ccgtgcagac catcaagtga 13081 aaattcgggg attccggatt gaattgggag aaattgaagc cgcgcttgtt cagcatccgc 13141 agcttgaaga tgcggcagtg atcgttcgtg aggatcagcc gggagataaa cggttagcag 13201 cttatgtcat cccttcggaa gaaacatttg atacggcgga actgcgcaga tatgctgctg 13261 agagactgcc ggattacatg gtgcctgctg cctttgtgac gatgaaagaa ttgccgctga 13321 caccgaatgg aaagcttgat cgtaaagcgc tgcccgctcc ggatttcgca gcggcagtga 13381 caggacgagg accgagaacg ccgcaggaag aaattctctg tgacctcttt atggaggtgc 13441 ttcacttgcc gcgtgtcggc attgatgacc gtttctttga tttaggcgga cattccttgc 13501 ttgctgtaca gctcatgagc cgcattcgtg aagcgctcgg cgttgaactc agcatcggca 13561 acttgttcga agcacctact gtagccgggc tcgctgaaag acttgaaatg ggatcaagcc 13621 aaagcgctct tgacgttctg ctgccgctcc gaacaagcgg agacaagcct cctttattct 13681 gtgttcatcc ggcagggggg ctcagctggt gttatgccgg tttgatgacc aatataggaa 13741 cagattatcc gatctacggc ttgcaggcac ggggaatcgg gcagcgcgag gagcttccga 13801 aaacacttga tgacatggct gccgattaca ttaaacaaat ccgaacggtc cagccaaaag 13861 gcccgtacca tctgctgggc tggtccctgg gcgggaatgt cgttcaagcg atggctaccc 13921 agctgcaaaa tcaaggagaa gaagtttccc tattggtgat gctggatgcc tatccaaacc 13981 acttccttcc tataaaagag gcgccggatg atgaggaagc gcttattgcc cttctggcgt 14041 taggcgggta cgatccggac agcttagggg acaaaccgct agattttgaa gcagcgattg 14101 agattcttcg ccgtgacggc agtgcgcttg cgagcttgga tgaaacggtc attttaaatt 14161 tgaagaatac gtatgtcaat tctgtcggca ttttaggctc ctataagccg aaaaccttcc 14221 gtggaaatgt tttgtttttc agatcaacaa tcattcctga atggtttgat ccgattgaac 14281 ctgattcgtg gaagccttat attaacggac agattgaaca aattgacatc gactgccgtc 14341 ataaagattt atgtcagccg gaacctctgg ctcaaatcgg caaggttctc gctgtcaaat 14401 tggaagagtt gaataaataa gggaggagaa atagaatggc aaatcctttt gaaaatgcgg 14461 atggcacgta tttggtgctg atcaatgaag aaggccaata ttccctatgg cccggtttta 14521 tagatgtgcc gagcggctgg acagtcgttc atgagcaaaa agggcgtgaa gcttgtttgg 14581 actatatcca atcgcattgg agcgatatga ggccaaacag cctaaagact gttgaaaatg 14641 tgtaatcgta tcaaaaagag actgctcgcc gcagtctctt tttctatctt acgcagacgt 14701 ttgggtatga tcacaatccc tgaccgggtt tccgttttca tctgtacacc aagattggga 14761 taaaaacgct aaaaacacag cggcccactg atctgcaaac tgaatcagaa tacccccgtc 14821 atgccaagag ccgttgtctt ttttccagcg ggtatccatt gcattccctt gattcatatg 14881 gatattgtgc attccgttag tcggggtaaa gccgaatatt ttatctgcag cctgttcagg 14941 gccgaatttt gaaccgaata tataaaccgg cgctttctca tcttgtgctt tcttcatata 15001 ggtttcaata aaatcattta aatcattatc aggtcctgtg atttcatgag gcaaaggctt 15061 catttcccgc gggtcaaaca aattgccccg cacataatcc agtgccactt cacggtttgc 15121 ttcattgatc cttgtatatc catacggcat gttcggaagg atggtaattg agcccgaatc 15181 aaactgatcg tcagccaaat acaatacttc agattcctca gaactggaca tcacattgat 15241 ggcgcacctg taatacgtat tctcttcacc gagcattttg acttggaaat gaggactgtc 15301 atcatctgtt tcccgcttca tgtctaagac tatgcctttt aacacgccat attgctgaac 15361 agccatatga atcctccttt atgatcaact tcatagtcat aattcgtgaa atggtctctt 15421 ttttcctttt aaaaaataaa aaagcctgca gaaatctttc tgcaagctca ttgtgaatta 15481 agcacccgct acagatgatt catcctgtaa agctttctcg gcaggaacat actcatagcc 15541 tagatctctt gctacagctt cataggtcac gtgtccgttt gcggtgttta aacccgctct 15601 cagtgccgca ttgtctgcga gcgcttttac tgcccctttg ttcgcgattt gcagcgcgta 15661 tggaacagta acgttagtca gggcgattgt tgacgtacga gggactgcgc ccggcatgtt 15721 cgctacagca taatgcacaa ccccgtgttt ttcatatgtt ggctgatcat gtgttgtgat 15781 atggtcgaca gtttcgacga tgccgccttg gtcgatcgct acatcaacaa tgactgaacc 15841 aggtttcatt tgttttacca tttcctcagt gacaagagtc ggagctttag cacccggaat 15901 taataccgcg caaatgagga gatccgcttc cgctacagca tcagcaatat tgaccggatt 15961 agaaattaac gttttaatct gatggccgaa gatgtcatca agctggcgca agcggtctgc 16021 gtttaagtca atgatcgtca catctgcacc gagtccgaca gccattttcg ccgcgtttgt 16081 cccgacaacg cctcctccga taatcgttac ttttccgcgg gaaacgcccg gcaccccggc 16141 aagcagaatg ccttttccgc ctttaggctt ttctaagaat tgagcgccga tttgcgccgc 16201 cattctgccc gcaacctctg acattggcgt cagaagaggc aatgtccggc cttcactgac 16261 cgtttcatat gcgatggcag ttactccttt atccttcaag gcctgtgcaa gctcaggctc 16321 agctgctaaa tgaaggtacg taaacagcac aagtcctttg cggaaataaa catattcttc 16381 cggcagcggt tcttttacct tcatgaccat ttcggcgtcc cagacctgtt tcggatcagc 16441 aatgatttcc gctcctgctg actcataggc ttcattttca aatccgcttc caaggcccgc 16501 gcctgtttca accagcaccc ggtggccgtt tgaaatgagc tgagaaacgc ccccgggtgt 16561 taatgcgaca cggttttcat tgttttttat ctctttagga acccctatga tcatatctgt 16621 ctcctcctgt atctgtgata tttttagtgt agcttgatat tttggaaaat tctttgtttg 16681 attaagaaaa taaaaaaaca tggatttgtg aaatttcaca aatccatgtg ccgaagtttg 16741 atatctaaat agatggtgaa tttttgattc acatttttca aatcaatttc agcgatctgg 16801 ctgatccgct tgagtcggta attcagcgta ttaacgtgta tatttaacag cttggaagcc 16861 gtattcacgt tgctgtccgc ttcaataaag cgctctagcg tctctaccag atttgactgg 16921 tgatcccggt catattgttc cagtttggaa agcgagtaat tataatggcc cgcctgtttc 16981 cgtttttcat ttaaaacatc taagtattga taaatgccta actcagaaaa gctgaaaaga 17041 tgtttggtct cttcagcgaa ccgttccttc gtttttaaga cggacaatgc ttcctgatag 17101 gagcgggaga caaaagaaat agagttgtat attccgccaa aagcgataga aacgtcttct 17161 attttatacc gctccttcag ctgtttttgc gtacttaaag caaactgttt taaatcttga 17221 aaaggatgat ctgttttggg tgaggttaat ataataagtt cattggaatc tacggtcgcc 17281 agcagcacgt aaacctgctg ggtcgtttcc tgtaaatatt gcagctgctg ttcgattttt 17341 tcagtcagct cgccatttat gcggatgatc ataacggaga actctgaagg agcggccatt 17401 ccaagcttat ggaacccatc cgccatatca tcctcctgat ggatgtgtcc ggtcagcatt 17461 ttccagaaaa attcttggct gcgttcttca tttttcgttt ttctgatttg aagtttgaga 17521 agcttgtttt tcactgcttt tgctgccatt tgcaatgtca gcagatcttc atcggacaat 17581 gttttttgga tctcaagagc ccatatgaag ccaagcactt gcttgttttt ccaaatcgaa 17641 atagcgacgc gattgctcag cccgacttca tcaatttgct tgactctgat cggctggtcc 17701 gtttttaaga gagctggaat tgtcccgtct ttccacaact tgttaatcac cttctccggt 17761 acccttctgc caataatggt agacgtccgg gcagggtctg tgcagtcgct gtgtgtactg 17821 taggcaagca gcttgtggtt aacatcctct atggtgatcg ggcaccgcag aacgtcgctg 17881 atatgatcag ccacatcttc aagtctgtca aaactatatt taaacggatc attcggcatg 17941 gtcataaatc tccctacttt tcgtgcttga tttctctttg acatctcatc cccttccttt 18001 tattatgatt gttgttgttt gtgaaaatca acaacaaaga acagaagcaa aaaaacaatt 18061 tcatgagaga aacgttctat atacatttgg cggtgtaatc gcctttttgc aggacagttg 18121 tatgcctcat ataatacgac agcttatcct attaatcttt taagtaagtc atcggaggcg 18181 agactaatta aggaaagaaa aaactgaacc tttcagaaat ggtgctgtag catcaaattt 18241 tctgaaaggt tttttttggg agttggggag ttatttgggt cttttggatt attcggagaa 18301 tgaagaggag attaagaaaa taaacctatt tactttacag tttatgtcat ttttaagtga 18361 ttcggggtaa accattggac tcattttgta aaattaaaac atatttgttt gactatgccg 18421 aaaaactgtt tttataataa tgacgttcta aaaataagtg aattagccca tatttaggct 18481 gatggcacag gaggtaatga ggaatatggc aggattaatt cgtgtcacac ccgaagagct 18541 aagagcgatg gcgaagcaat acggcgttga aagccaagaa gtattaaatc aggttgatcg 18601 tttaaaccga atgatctctg atttgaaaag catgtgggaa ggtgcttcaa gcgaagcgtt 18661 cgcagatcaa tacgagcagc tcaaaccttc atttatcaaa atgtcagatt tgcttcaaga 18721 tgtgaatcag cagcttgatc aaacagcaaa tacacttgag tctactgacc aagacatcgc 18781 aaatcaaatc cgcggataac agtatgaaag ggaaggagcg cctgattcaa aagaagacgg 18841 cgctctttct atgtaagggt gatcctaaat gtatattgat attacaatag atttgaaaca 18901 ttataacggc agtgtctttg atctcagatt gtcagattac cacccggtga aaaaagtaat 18961 tgatattgct tggcaggccc aaagcgtatc tatgcccccg cgcgaagggc actggatcag 19021 agtggtgaac aaggataagg tgttttccgg agaatgcaag ctgtctgatt gcggcattac 19081 aaacggagac cggcttgaaa tattatgaaa ggatctggtt gaatgtcagg taaacaaaaa 19141 tcatatttag aaaaccaatt agaagctgtt gccgagaaaa cagatgccgg ctatacattt 19201 acctttcaac gggaaaaaat aaagcttctc gacggtcttg aagctaacgt gatcaaagat 19261 ataaatccat ttttttataa agaaatcgat gtgacggatg atgaagtaat catcacaatc 19321 caacctccct cctcctataa agcattccgc ttcatgaaag ctaaggataa aaaaagtaaa 19381 tggcagtttg cctatcagct tgttcaagcc gtacagcagc acaatctgtc gaggctgaat 19441 ttgattgtcg ctcctgaaaa cattgtattc gataaagggc ttacgcctta ttttctccat 19501 tatggagtaa aagaaagcat tcctccttac gagcgtgatg aggaaagagt atggcaggag 19561 ctgaaagcgg cagcggcttt ggcagttgac ggcgcttttg cgtttgaaga ctacctgaaa 19621 ttcaatgaaa cgctcacgtt ctccgcagag gcaaaggcga tattagatac tgaatcctat 19681 gatgatttgc tcgagctgat tcaaatccat attgatgagc tcgaagccaa agcaaaaaca 19741 tacatacata tcccgagaaa gaagtggaac atccagcgat atatcggcct ggggctcatt 19801 gttttgcttg taccggcact tatttattcg atgtacgcct tatttttcgc gcagccaaag 19861 caccaggcga tagtggacag caaccgtgcg ttcttaaaca agcagtacag tgaagtcatc 19921 agcacactgt ccaagtacga ggcggaaagc ctgcctgaat cggtgcagta tcagctggcg 19981 acgtcctatg ttgaggtcga aaacctgggg agtgcaaaaa ccaaaaatat agaaaataac 20041 ttagtcaccc ttcaatcaga ccctcagcat ttcttatatt ggattgatta tggtagagga 20101 gaatacaaag aagcgatcag tatcggccgt aagcttgaat acaatgatta tatttacttt 20161 gccctagcta aatataaaca gcagctttta tctgaggata caaatgatga agatatacaa 20221 aaagaacttg actcagtaaa tagtgagctt gaaaaagccc aaaaagaacg tcaagaaaat 20281 aaacagtcta attctgaaac atcgttagtc gatacaagcg aagaacagac acaaacagac 20341 gaagaaaaac aagcagaaga gaaagcggca gaagaaaaag ccgcagccga ggaaaaagcg 20401 aaaaaagaag aacagaagaa aaaagaagac gagaaaaaag aaacagaaaa gaaagatgag 20461 aaaaaagatg acaaataacg tgagacatga agcacaggtc atcgcatgct gccattcggc 20521 cgtaaggggg ttcgccattt gagtctatta tgggtttttt accaaaataa cgttcaaaaa 20581 ttaaatctgt ctaacctccc gtcgtctcat ccggtgacca tagggcctga tgtgaaggat 20641 tctgttacga tcagctccat tccatttaat agcggagtgg tttctcttaa aagaaaggaa 20701 tccggcggcc aatacgaagt tttcctggga aatgattgtc tcggcacgat tgaggcggat 20761 acatcattta ctctccaaac ggatcagcag gatatacgtt tgatattgac aggcagtgaa 20821 cctgagaaat ccgtttattt tacgggaaat cgggatgaaa ttgtatgttc ctcagaaaaa 20881 acgaatgcag atatttatct gaatccgcaa gattttgcat ttgcagaaca aagcacgttt 20941 tctttgcttc gtgcaggcgg cagctggtcg gtccgccctg aaagcggaac gatcttcttg 21001 aacggagaga aaatcaacgc caatacgccg ctcaagccgg gggatgaaat attctggaac 21061 ttcacgcaaa tgagggtgac ggaacaagac cttttagaaa ttgttcatta tgcccagttt 21121 gaaacagcgt taacagaaac ggtcaaaccg agtacagaga tgcagaaaaa atatccgcag 21181 tacagaagaa cgccgcggat ggtatacgat ctcccggatg accgcgtttc tttcagtttt 21241 ccctctcagg agagcgatca aaccaacaga gggctgtggc tcgtcatcct gcctccgctt 21301 gtgatgctga tcgtgatggg cgtagttgcc atcatccagc cgcgcggcat atttatactc 21361 gtttctttgg ccatgtttat gatgactcta attacctcga cagtgcaata tttccgggat 21421 aaaaaccagc ggaaaaaacg cgaggaaaaa cgggagcgtg tatataagct ttacttagac 21481 aataagcgga aagagcttca ggcacttgct gaaaagcaaa agcaggttct tgaatttcac 21541 tttccttcat ttgaacaaat gaaatactta acaagtgaaa tcagtgaccg gatctgggaa 21601 aaatcacttg aaagcaagga ttatctgcaa ctgcggcttg ggacgggaac agttccgtca 21661 agctatgaaa tcaatatgag cggcggagac ttggcgaatc gtgatatcga tgacctcatg 21721 gagaaatcgc agcacatgca gcgcgtctat aaagatatcc gccatgcgcc ggtgacggtc 21781 gatttggcag aaggtccgat ggggcttgtc ggtaaatcgc aaattgtaaa aaatgagatt 21841 caccagttga ttggacagct gtcgttcttt aacagctatc acgatttgcg ttttgtattt 21901 atttttcatg aagaagagta taaagactgg gagtggatga agtggcttcc gcaatttcaa 21961 atgccccata tttatgcaaa aggatttatt tataatgagc aaacccgaga tcagctcttg 22021 tcttcacttt acgaattgat cagagagcgt gatctcgaag atgacaaaga aaaactgcag 22081 ttcaaaccgc attttgtatt tgtcatcacg aatcagcagc tgatctctga gcatgtcatt 22141 ctcgaatatt tagaaggaca gcatgagcat ctgggcatct cgacaattgt cgcggcggaa 22201 acaaaggaaa gcttgtcgga aaacattaca actcttgtcc gctacattaa tgagcatgaa 22261 ggcgacattt taatacaaaa gaaaaaagcg gtaagaattc cgttccgtct cgatcatcat 22321 cagcgtgagg acaacgaacg gttctcacgc acgctgcgga cgctgaacca ccaggtcggc 22381 attacgaatt ccattccgga aacggtatcg ttcctggagc tttttcatgc gaaggaagta 22441 aaagaaatcg gcattcagca aagatggctg acaagtgaat cgtcgaagtc gctgtcagtg 22501 ccgatcggct ataaagggaa agatgacatt gtgtatctga accttcacga aaaagcacac 22561 ggtccgcacg gcttgcttgc ggggacaacg ggatcaggga aaagtgaatt tctccagacc 22621 tacatcttgt cacttgcagt gcattttcat ccgcatgaag cggctttctt actaattgac 22681 tataaaggcg gaggaatggc gcagccgttc cgcaacattc cccacctcct cggcacgatc 22741 acaaatattg aaggaagcaa aaacttcagt atgcgtgcgc ttgcttccat taaaagcgag 22801 ctgaaaaaaa ggcagcgcct gtttgaccag tatcaagtca atcacatcaa tgactataca 22861 aagctataca agcaagggaa agcagaagtg gcgatgcctc acttgttctt aatttctgat 22921 gagtttgccg agctgaaaag cgaggagcct gattttatca gggagcttgt cagtgccgcg 22981 cgtatcggac gaagcctcgg cgttcatttg attttggcga cacagaagcc aggcggcatc 23041 atcgacgacc agatctggag taactcgcgc tttaaagtag cgctcaaggt ccaggatgcc 23101 accgacagta aagaaatttt gaaaaacagc gatgccgcaa acattaccgt aacaggccgc 23161 ggctatttgc aggtcggaaa caatgaagtg tatgagctgt tccaatctgc atggagcggg 23221 gcgccttact tagaggaagt ctacggtacc gaggatgaaa tcgctattgt tacagatacg 23281 ggtctgatcc cgctttctga ggttgatacc gaagataacg cgaaaaaaga cgttcaaacc 23341 gaaatcgaag ctgtagttga cgaaattgaa cgcatccaag atgaaatggg aatcgagaag 23401 ctgccaagcc cttggctgcc gccgcttgcg gaccgtattc cgcgcactct tttcccttca 23461 aacgaaaaag accatttcca ctttgcgtat gtcgatgaac ctgatctgca aagacaggcg 23521 ccaattgttt ataagatgat ggaagatgga aatatcggca tcttcggctc ttcgggctac 23581 ggaaaatcga ttacagccgc aacgttcctg atgagctttg cggacgtata cacacctgaa 23641 gagcttcatg tctatatctt tgatttcgga aacggaacgc tgctgccatt agcgaagctc 23701 ccgcataccg cggattactt cctgatggac cagtcaagaa aaattgaaaa gttcatgatt 23761 cgcatcaaag aagaaattga ccgccgtaaa cgtttgttcc gggaaaaaga aatcagccac 23821 atcaaaatgt acaatgcgct gagcgaagaa gagcttccat tcatttttat caccattgac 23881 aactttgaca ttgtcaagga tgagatgcat gagcttgaat cggaatttgt ccagctttcc 23941 agagacggac aaagcttggg tatctacttt atgctgacag caacgcgggt gaatgctgtc 24001 cgccagtcat tgttaaataa cttgaaaaca aaggttgtcc attatctcat ggatcaatca 24061 gaaggatatt ccatttacgg ccgtccgaaa ttcaatcttg agccgattcc gggacgcgtc 24121 atcattcaaa aggaagagct ttatttcgcg caaatgttcc tgcctgttga cgccgatgat 24181 gatatcggca tgttcaacga gctgaaatca gacgtacaga aacttcaagg gcgatttgct 24241 tcaatggagc agccggcacc gattccgatg ctgcctgaga gcttgtctac gagagaattt 24301 tctctccgct tcaagctgga acgcaagcct ttatctgtac cgatcgggct tcatgaagaa 24361 acagtcagcc cagtctattt tgatttaggc aagcataagc actgcctgat tttaggccaa 24421 actcagcgcg ggaaaacaaa cgtcctaaaa gtcatgctcg aacatctgat tgatgatgaa 24481 actgaaatga tcggcctgtt tgactcaatt gaccgcggct tatctcatta tgcgaaggaa 24541 tcagatgttt catatttgga aacgaaagaa gatattgagc agtggattga aacagcagaa 24601 gacattttca aaactagaga ggccatgtat gtggaagccg tccgccaagg agacgcgcaa 24661 aatctgcgat tctcacaagt ggtgctgatg attgacggga taacgagatt ccagcagacg 24721 attgatacga gaatacaaga ccgtctcgct aacttcatga aatcatacgc tcatcttggg 24781 ttcagcttta tcccgggcgg aaatcacagc gaattttcaa aaggctatga ctccttgacg 24841 actgagatga agcaaatccg ccacgcgatt ctgctgatga aaaagtctga gcaaaatgtc 24901 attcctctcc cgtaccaaag acaggagcct gagattcagc cgggcttcgg atatgttgtg 24961 gaaaacggga aggagcaaaa agttcaaatt cctttatgtt ctgctgaaag ggagagtgct 25021 agatgacaga acaacgaaaa agcttgatca agttaatatc cgccgtcatc atcattttgc 25081 tgctgccggt gttgtttttc cgatttatcg gagacgaccc aacgaaaaaa gcagtcaatt 25141 ccacccgaca aatcgcggtg gtgaatgaag acacaggcgt attgagtgat gaggtaaagt 25201 ctgatgaaga ggacaaatcc gcccagttcg gcaaggaagt agcggccgtt ctgggtgaac 25261 gtcctgatta ttcgtggacg gtcgtaaacc gaagcgcggc cgagaccggt ctcgcttcaa 25321 agaaatacga tgcgattgtc tacattccct cagacttctc aaaaaacatt ttgagctatg 25381 acaaagacca tcctcaaaaa gcaacgctcg aattcagcat tcaagataac ctgaatgcgg 25441 ttaacaaaga aaaagttcag cgtgagcttg aggatgccca aaagacaatg aacaaaaaaa 25501 tgtcggcctt atactggaat tttgtttcac aaaaagtgga caacatcaga ggagaatttg 25561 acaagatcgt caataaagaa tctgaattcc agaatgtcat gtacaacttt tacaaaccaa 25621 gctctaatga tttagcaggt gaaatcaaac agcaaaaaga cttaatcgat gagctgaaga 25681 aatcaatgaa tgaagcgcaa ggcacgacaa aagaaaaagc ttctacagcg gaggaagcca 25741 aaaatacgct gaaagaattc attgatacag ttgaaagata caaagaatat caagaaaatc 25801 agaaaaagct gcttttggca gcccaagatt caacacagca gcaaatccgg acaggtctgg 25861 atgccatcca agcacagcaa aaggcgaatc agttcagcga acgcatgagc ggattggcaa 25921 ctgggattgg ccaagcgaag acacagctcg gacttactag tcttgctctg aaaagtgcag 25981 aacagacaag gcaaggtcaa gttcctttac aagaaatggg catgaaaaaa attcaagaag 26041 atatgttcag tacatttctt gaacgttatg aaactcagta tactgcaact aaaatccaaa 26101 acttaaatca attgcaagat aagatagtga atcttcgtcc ggctttaata aaaccagagg 26161 aagacgatca aaagcacgat aattctaatg aagagaataa tgacaaggaa gaagatacaa 26221 ctgaagaaat caaattggac ttggagcaac aacgagatga actcaataat gttgcagctg 26281 aaatcaaaga tatttctgaa ggattaaaag aaccagaact aaataaccca acaatgccgg 26341 ggagcgaaga cccgacaaac gacgacaaca ccaataataa aaatccaaca agtggcgatc 26401 agccgacaga tggaaatgat gggtcaacag atgacagtac acaaatgaac cctgaaataa 26461 ataatgaagc agacaatcaa ggtcaacaaa attcttccga gaaaactaat gatttaaatg 26521 gcaaaacaga gacgacagca caatcaaaag ccgcccttcg tataattcag ctcgctgatg 26581 aaaacgatgg gtcacaggtt gacgattcta aaaacgaatc agatatttcg atagcaaaaa 26641 aacgtctgaa tgctgcagct gaacaaatac agaaaataga ggaagaactt aaagaaaagc 26701 aagaggagca taatagtaag gttgagaagc gcattgagaa actggataaa gaaataaaag 26761 atctaaatga taaggttgac tcattaaaca tcaaaattaa tgacttaaca tcaaaattta 26821 atgatatcaa tgatcagttt aataaatctt ctttattaat tagtgaaaag gaaaaagaga 26881 ttttaaaaat tttacggaat aacggtgaaa aagatcgctt agaacaatta tcttcagttt 26941 ttactaatac agtagataca aaaaatgttt cagacttaat gaagtactac aattatctat 27001 atttgtatga aaagactttg actggttctc tagatgtagg gtctatgtcg ctcttaagta 27061 gagacgctat ccagggccag cagggcaacg tcaaatcagt cctggctctc acacctgaag 27121 aatcagccag ctgggaagct ctcaaaaaca acacgatgca aacagatgag gatattaaca 27181 gcttcatcga cggcatgacc aaatttgcgg acgactacag cggctatatc cgtgactctc 27241 aagcaggtgt tctcgacgaa ctgacgaaaa tctctgaaag tgccgcaaaa acgtcagaac 27301 agcttgtaac gggcgcaaca caggaatctg cgacgttcag caacgatggg ctgtctggca 27361 ccatggcact gagtgtccaa gatacggtcg gccaggaagt gctgcaaatg tcagacatga 27421 tgggttcatt gtctgatcgc cagtccggca tcattgatta cacaaccaac atgcagcaaa 27481 gcgtcaatga tgttcaagcg aaagccgaca ccttaaacaa caactggggg aaaaatgtcg 27541 cctccacgaa actcgtgcga aatgacgtat acggcatact cggaaataca ttagtagacg 27601 ggcaaaacaa tggctatgta tatgattact tagcgaatcc gcttaaaatc agcggagagg 27661 ttccggaaga aaaaattcag acggtacctc cggttgtcat ccttgtcatt gtgttgatca 27721 gcagtctatt aatcggctat ttcagctcgt attaccaaaa cgcaccgctt ctcgtcaaag 27781 gagcgttatt cggaattctg aatatccttg tcggacttat gatcagcttg ttcggcttga 27841 atatttattc actgccggac gatcagacga ttaagtggtc ggtgtttacg attctattgc 27901 tggtcgcaag ctctgccttc atccggacgg cattcagatt cggatcaatc cctggctggg 27961 ttgcttcagc ggcaatgatt ctattctatg tcgcaccgct tattgatttg atcatgccga 28021 actttacatt tgaagatccg gtttcgaaag tatatatcga catccagtac ggtactgggc 28081 acttgtttac aatgggaata acagttctgc tgatcattac ggtgattgcc gcggctctgc 28141 cgctgattat ccggctgatg gctgaacaca cagcagaaag cgatgaaacg tatgaagcgt 28201 gatcgcagca tggaaaaggg gatcatgatt tgtatgctct ccttttccct tttcataccc 28261 tctgcagcgg ctgcccaaac tgaagaaaat acagatgtcg cgccaaacca gtatgagaaa 28321 aaagacatcg aaatcgatac gaattatttg catgaagata cctactatga agaaaaaaca 28381 gaactgcctg aggaacaaaa ggatatcact tttgataaac cgaaggacaa ggacgccgag 28441 ctgataaaag atttgtttac atcaacaaat gccgaggatt ccaacacgat tgcggcccag 28501 tcgaaacagc ttggaattac atttgcagaa aaaccaataa caaagacatc atcaacggaa 28561 acagaagatg aacaagaaac atcatcattg ctgctgccga tgatctatgt cgtactgatc 28621 ctgctcggaa ttgcaggcat cgtgttcctc atcccaaaag tcacagcgca ggaaaacaag 28681 aaggcgtagg ccgcgtgctt gtgttgtgta aaagcagtgc cgtacaataa taacggaaaa 28741 ggaggtttcc aatggaactt tatatcatca ccggagcgtc aaaagggctg ggtcaagccg 28801 ttgcattaca ggctttagaa aaggggcatg aagtccatgc cttatccaga acgaaaacag 28861 atgtctctca tgaaaaacta acgcagcatc aaatagactt catcaatctt gaagaagctg 28921 aacagcaatt tgaaacattg ctctcatcca tcgatccaga gcgttattct ggtattaccc 28981 ttatcaataa cgccggaatg gtaacgccga tcaaacgtgc cggcgaagcg tctcttgacg 29041 agcttcagcg ccattatcag ctgaacctga ctgcgcccgt gcttttgagt cagctgttta 29101 caaaacggtt tgcttcatac agcggcaaaa agacggttgt caacattact tcaggagccg 29161 ccaaaaatcc atataaggga tggagcgcgt attgcagttc aaaagccggg ctcgacatgt 29221 ttacgaggac attcggattt gaacaggagg atgaagagct gccggtgaac atgatttcgt 29281 tctcacctgg agtgatggac actgagatgc aggccgtcat ccgttcttca tcgaaaaagg 29341 attttcacca cattgaacga ttccggaaat taaatgaaac aggaagcctt cgcagtccgg 29401 actttattgc cggcacgctg ctttctttac tagaaaaagg gacggaaaac ggccgcattt 29461 atgatattaa agagtttttg tagagcagat attttctgct ctttttttta tacaaaaggc 29521 tgcagccagc gcattttatt gaacagccgc atatactgac tgaaacgctg cttttagggt 29581 ataacaatga tgataagaag atcaaaatga tgtgacataa gaattgagtt tctctgcaaa 29641 ttatgttagg attctaaaaa tatctaaagg aggggtttcc atgagaaagg ttacattaat 29701 ggatgttttc acccatccaa ttgcacaaaa atatcttcag cgttccggcg tggcacatgc 29761 gattgcctgc gcttatcatg catacaggct gtctgtgaag gctgacatta atcctgattt 29821 agcagtaaaa gcggcactgc ttcatgacat tggccattat gaatggtata cagacggaaa 29881 gtgggattat gagaaataca aaagaaatga cattcatgcc attaaagggg cggaacgggc 29941 gcataaactt ctgattcggc ttggcgagga accgaaagca gcaaaagaga ttgcactagc 30001 cattttgctt catacagatt cctatttgcc tgaaggcgaa ttagataaaa acacactgca 30061 gcagattgtc aaaaaagcgg acgaactgga tgaagagccg ggcggccacc atcattaccg 30121 ccaaattgat ccttcaaccg cacgaaaaaa aatagaaaag ctggaccaat taatcgacca 30181 agctcaggca tccgtgataa agcctgtata agtacggaac agcgccagct ttcttcgctg 30241 tctccgcttc atcgatactt cctttacacc cgcttccaaa cgtattcccc taaaatctcc 30301 gcaccccttt gttttatcag gtaagcctgt gtcattatcc ataagcgcgg cataagctga 30361 gatagaacac acaaagggga taaaagtatg gtcaaccaag gtagtccgca actggtctct 30421 ttagtcgatc cttatgtcta tcagaccatt aaaaagctca tcggctcaag gttcgttata 30481 cagacagtac gagatacggt cagaggcaga ctgatcgatg taaaacctga ccatatcaca 30541 attgaaggag cccgaaattc tgtttgtttg atcagaatcc agcacatgat ttccgtcatc 30601 ccagattaca gtgagcgggt ctaacagtgc ttgcgcatga aaaataggcg tacaccggga 30661 cgtcctattt ttcagttaag cgctgtaaaa acgcactatg atacattgtt ccatcaaggt 30721 caaagccggc aaattcctga tagtcaccat ctgaaaaaca gaaagtgaca ccgtacaccg 30781 tatagcagga acggactgaa gcatgctggc agacccgaaa atgataaccg tctgaatctt 30841 ttacatatag ccgggatttc ccggcaaatg gggcacagag gtgtgctgcc tcaccaaaac 30901 attcgaatcc ggcgattttg ccatcttggc tgatatctag caggagacaa tcattgactc 30961 tgagctcctc agtccgtaca tttctgttct ttttcggagg aagaacatag atataagcca 31021 gttctgaatc tgtatcgtat gtcacggcct tcatcaccaa cactcctttc attatattaa 31081 gagttctgat atgagttcat ttttgttaca atgatggggt ataagttctt ttatctgaca 31141 gacaaagaaa aactaggagg aacaaagctt gttgaaatca aaagtccatt tttggacatt 31201 gcagatttta tttgttttgc tgattatttt tgtagcaaca aaagtttcat ttgtatttca 31261 gccgtttatt gtttttatct cgacattgtt tttcccgatg ctgattgcgg gaattttgta 31321 tttcatattt aatccggtcg tccgcctgct tgaaaaaaaa attccgcgga cattatccat 31381 tctattgatc tatttactgt ttatcggttt gcttgccttt atttcagcgt cagtcggacc 31441 tatcatcacc tcacaggtga cagggctgtt taacaacctt cctgattata taaaacagat 31501 tcaggcgctg acaaaggatt tgtcccattc tcaatggttt acctggatga tgaaccagga 31561 ttatgtatcg atatcaaaaa ttgaacagtc attgacaagt tttctccaaa acttgccgca 31621 aaatatcacg tccagtttat ctgcggtgtt tggtgtcgtg acaaacatca cgcttgttat 31681 tattactgtt ccatttatcc ttttttacat gttgaaagac ggacaccgct ttccgcattt 31741 ggcagtaaaa attctaccgg cttcttatcg gacagaaggc ttaaagattt ttaaagattt 31801 atccgatacg cttgcggcat atttccaggg gcagctgtta atctgtcttt ttgtcggaac 31861 agcgtgtttt atcggctatt taattgccgg actgccgtat gccctgattc ttgggattgt 31921 catggcgatt accaatatca ttccctatgt cgggcctttt ctcggtgccg cgccggctgt 31981 cattgtcggt tttatggact cgccggccaa agcgctgttt gcgattattg tggtcgtcat 32041 cgttcagcag ctggacggaa acctgctgtc tcctcttgtg atcgggaagc ggctgaatac 32101 ccatccgctt acgattattt tgctgttaat cggagcggga agcttcggcg gaattctcgg 32161 catgatttta gcggtgccgg tttatgcggt agtgaaggcg ttcttcctga atattgtccg 32221 cttgatcaag cttcgccagc ggtcacgact cgaagaaaac gcaaagccag ctgaataggc 32281 gggcaccatt atcggctctt tgcatatgat gctgtaaatc aatgcggagg tggggaaatg 32341 cctgcaattg tggggccgat ttatatcatg tcagttacgg gtaatgccgc ggcaagcttt 32401 ggagacatat ttgcgatttc gcccaaaagc gtcgctcatt caggggcggg gtcaggcgca 32461 tttcagcttg gtgattttgt gaagattaac aaccaaacga gtaaaactct cttcgaagat 32521 gccgatatca ctgatgaaac agtttcgttt aacgggtaac agccttttca caagaggctg 32581 ttgctttttt attgtataat atgggtagtc tttaaataga gaggtcatgt tatgaaaatc 32641 agaaaagcaa atatcaatac gcaaaccgga atgatcacgg acgtgtatct gcatgaaaac 32701 agaaaagaac tgcgcacgct tgtagcggta ccgcagctgg agtggagcac gatcatttcc 32761 tatgaagaag ataaagcaac tctgcctgaa cggctggaag cgtcgttgcg ccggcataca 32821 gaggaaaccc ctgctggtga gctggccaaa aaaatcattc attgggtaac agaaatgtaa 32881 acggcgcttg aaagtttagc tcctgcctga tcaggtgata atgaagacaa acaagacggg 32941 aggacaggct tttgagtgaa gacaaaatgg atctctattt gcagcaagga atgtatgggc 33001 ctttggagac aaagcctgac gagcgccatt tgtttttagg ctctttaaga gaaagagtcg 33061 ttttggcact gacgaaagga caggtgctta gaagcaaacc gtataaagag gcggagcacg 33121 agctgaaaaa cagccataac gtcacccttt tggttaatgg agagcttcag tatcagtctt 33181 actctcctta tatccaaatg gcgaaccggt acggagtgcc cttcaagatt gtatctgatc 33241 ttcagtttca tacgccttta ggcctcgtta ttgcggctga catcgctgtg aatcgtgaat 33301 tgatatatat tcaggacgac atttataatc ggtcagtgct gaaatcttaa gagacaaacg 33361 ggtcgtttgt ctttttgttc atggcaattc acttacaact ggagataaga tataatgttc 33421 tcatactgat ggcggggagg ccggctatga aaaaagcact tatttgtatt gattatacga 33481 atgattttgt ggcgagtgac ggaaaattga cctgcgggga gcccggcaga atgattgaag 33541 aggcgatcgt caatttaacc gaagaattca tcacaaacgg tgattacgtc gtattagcag 33601 tagattctca tgctgaaggg gatcaatatc accccgaaac ccgtcttttt cctccgcata 33661 atataaaagg cacggaagga aaagatctgt acggaaagct tttgcctcta tatcagaaac 33721 atgaacatga gcctaatgtt tactacatgg aaaaaacgag atattctgct tttgcgggaa 33781 ctgatttaga gctcaaactc agagagcggc agattggcga actgcacctt gccggtgtct 33841 gcacagatat ttgtgtgttg catacagctg ttgacgcata taacaaaggt tttcggattg 33901 ttgtgcataa acaagctgtt gccagcttta atcaggaggg gcacgcatgg gctctttccc 33961 attttgcaaa cagcatcgga gcgcaagtgg cagagtaagg aaggggaaaa acagtgttag 34021 agtacggatt taaagatgac agcctgtcat tacatacaga cctttatcag atcaatatgg 34081 cggaaacgta ctggagagac ggcattcatg aaaagaaagc gatttttgag ctgtttttca 34141 gaaggcttcc gtttgaaaat ggctatgccg tatttgcggg cttggaaaaa gccattgaat 34201 acttggaaaa tttcaagttt acggatagcg atttgagtta tttacaggat gaactcgggt 34261 atcatgaaga ttttattgaa tatttgcgcg gcttatcttt tacaggttca ctttactcta 34321 tgaaagaagg agagctcgtt tttaacaatg agccgattat gagggtggag gcacccctgg 34381 tagaagcgca gctgattgaa acagctttgc tcaacattgt //