LOCUS gnlProkkaGAMLCGEA_24 25332 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|GAMLCGEA_24. ACCESSION gnlProkkaGAMLCGEA_24 VERSION gnlProkkaGAMLCGEA_24 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 19:36:14 Original ID :: gnl|Prokka|GAMLCGEA_24 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 25332 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25332 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[1504:5332]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 1505..5332 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" cand_cluster 1..25332 /SMILES="NC(CC(C)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="single" /product="NRPS" /protoclusters="1" /tool="antismash" region 1..25332 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRPS" /region_number="1" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" CDS 2..1468 /NRPS_PKS="Domain: Epimerization (22-325). E-value: 4.7e-161. Score: 529.1. Matches aSDomain: nrpspksdomains_ctg24_1_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (329-478). E-value: 5.9e-55. Score: 177.2. Matches aSDomain: nrpspksdomains_ctg24_1_TIGR01720.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 131.4; E-value: 8.5e-40)" /gene_kind="biosynthetic-additional" /locus_tag="ctg24_1" /sec_met_domain="Condensation (E-value: 4e-85, bitscore: 278.1, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MIEELTQYVERAEGKQADQGPVEGEVILTPIQRWFFEKNFTNKHH WNQSVMLHAKKGFGPERVEKTLQALIEHHDALRMVYREENGDIVQAYKPIGESKVSFEI VDLYGSDEEMLRSQIKILANKLQSSLDLRTGPLLKAEQYRTEAGDHLLIAVHHLVVDGV SWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEELAAFSQSAHLLQQAEYWSQIAA EQVSPLPKDCETEQRIVKDTSSVLCELTEEDTKHLLTDVHQPYGTEINDILLSALGLTM KEWTKGAKIGINLEGHGREDIIPNVNISRTVGWFTAQYPVVLDISEADASAVIKTVKEN LRRIPDKGVGYGILRYFTETAETKGFTPEISFNYLGQFDSEVKTDFFEPSAFDMGRQVS EESEALYALSFSGMIRNGRFVLSCSYNEKEFERATIEERMERFKENLLMLIRHCTEKED KEFTPSDFSAEDLEMDEMGDIFDMLEENLK" aSDomain 68..976 /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_1_Epimerization.1" /evalue="4.70E-161" /label="ctg24_1_Epimerization.1" /locus_tag="ctg24_1" /protein_end="325" /protein_start="22" /score="529.1" /tool="antismash" /translation="EGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFGPERVEKTL QALIEHHDALRMVYREENGDIVQAYKPIGESKVSFEIVDLYGSDEEMLRSQIKILANKL QSSLDLRTGPLLKAEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESL VFPQKTNSFKDWAEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSS VLCELTEEDTKHLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDII PNVNISRTVGWFTAQYPVVLDI" aSModule 68..1435 /domains="nrpspksdomains_ctg24_1_Epimerization.1" /domains="nrpspksdomains_ctg24_1_TIGR01720.1" /incomplete /locus_tags="ctg24_1" /tool="antismash" /type="unknown" CDS_motif 83..112 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_1_0001" /evalue="2.90E-05" /label="NRPS-E1" /locus_tag="ctg24_1" /protein_end="37" /protein_start="27" /score="16.7" /tool="antismash" /translation="LTPIQRWFFE" CDS_motif 182..247 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_1_0002" /evalue="3.70E-05" /label="C2_LCL_024-062" /locus_tag="ctg24_1" /protein_end="82" /protein_start="60" /score="16.1" /tool="antismash" /translation="ERVEKTLQALIEHHDALRMVYR" CDS_motif 452..517 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_1_0003" /evalue="3.10E-12" /label="NRPS-E2" /locus_tag="ctg24_1" /protein_end="172" /protein_start="150" /score="38.6" /tool="antismash" /translation="LLIAVHHLVVDGVSWRILLEDF" CDS_motif 920..970 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_1_0004" /evalue="1.20E-08" /label="NRPS-E5" /locus_tag="ctg24_1" /protein_end="323" /protein_start="306" /score="26.9" /tool="antismash" /translation="NISRTVGWFTAQYPVVL" aSDomain 989..1435 /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_1_TIGR01720.1" /evalue="5.90E-55" /label="ctg24_1_TIGR01720.1" /locus_tag="ctg24_1" /protein_end="478" /protein_start="329" /score="177.2" /tool="antismash" /translation="ASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNY LGQFDSEVKTDFFEPSAFDMGRQVSEESEALYALSFSGMIRNGRFVLSCSYNEKEFERA TIEERMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGD" CDS_motif 1010..1069 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_1_0005" /evalue="7.10E-12" /label="NRPS-E6" /locus_tag="ctg24_1" /protein_end="356" /protein_start="336" /score="37.3" /tool="antismash" /translation="VKENLRRIPDKGVGYGILRY" CDS_motif 1103..1132 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_1_0006" /evalue="1.30E-03" /label="NRPS-E7" /locus_tag="ctg24_1" /protein_end="377" /protein_start="367" /score="11.2" /tool="antismash" /translation="PEISFNYLGQ" aSDomain 1505..1600 /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_2_NRPS-COM_Nterm.1" /evalue="1.40E-16" /label="ctg24_2_NRPS-COM_Nterm.1" /locus_tag="ctg24_2" /protein_end="32" /protein_start="0" /score="51.3" /tool="antismash" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQ" CDS 1505..5332 /NRPS_PKS="Domain: NRPS-COM_Nterm (0-32). E-value: 1.4e-16. Score: 51.3. Matches aSDomain: nrpspksdomains_ctg24_2_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (9-308). E-value: 1.9e-118. Score: 386.8. Matches aSDomain: nrpspksdomains_ctg24_2_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (469-867). E-value: 1.3e-112. Score: 368.2. Matches aSDomain: nrpspksdomains_ctg24_2_AMP-binding.1" /NRPS_PKS="Domain: PCP (973-1042). E-value: 1.5e-25. Score: 81.1. Matches aSDomain: nrpspksdomains_ctg24_2_PCP.1" /NRPS_PKS="Domain: Thioesterase (1060-1267). E-value: 1.1e-36. Score: 119.3. Matches aSDomain: nrpspksdomains_ctg24_2_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 330.7; E-value: 2.7e-100)" /gene_kind="biosynthetic" /locus_tag="ctg24_2" /sec_met_domain="Condensation (E-value: 2.6e-93, bitscore: 305.0, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 9.5e-123, bitscore: 402.4, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 3.6e-18, bitscore: 58.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKG SLNIKCLEESMNVIMDRYDVFRTVFIYEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQT AKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLF KVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQ KDGYEPKELLFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVV SGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKQLQEQSLQSEPHQYVPLYDIQ SQADQPKLINHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEML IKFAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPA QTHETKPLTDWFKEAVNVNPNAPALTYSGQTLSYRELDQEANRLAHRLQKHGAGKGSVV ALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKEQAA QLPYTGTTLVIDDQTRFEEQESDPATAIDPDDPAYIMYTSGTTGKPKGNMTTHANIQGL VKHVDYMAFSEKDTFLSVSNYAFDAFTFDFYASILNAARLIIADEHTLLDTERLTDLIL QENVNVMFATTALFNLLTDAGEDWMKGLRCVLFGGERASVPHVRKALRVMGPGKLINCY GPTEGTVFATAHVVHDIPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCISGMG VSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIRGHRI ELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYM VPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNDMEETIAQIWSEVLGRKQ IGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYVKNGGPDGLQ NVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLIQK LQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVESDV EALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVSLISTGQVKADIDLLTSGAAFDMPE WLASWEEATTGAYRMKRGFGTHAEMLQGETLDRNAEILLEFLNTQTVTVS" aSDomain 1532..2428 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_2_Condensation_DCL.1" /domain_subtypes="Condensation_DCL" /evalue="1.90E-118" /label="ctg24_2_Condensation_DCL.1" /locus_tag="ctg24_2" /protein_end="308" /protein_start="9" /score="386.8" /tool="antismash" /translation="QDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEE SMNVIMDRYDVFRTVFIYEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQTAKINEYKEQ DKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQ KPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQKDGYEPKEL LFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKG VEHMVGLFINVVPRRVKL" aSModule 1532..5305 /complete /domains="nrpspksdomains_ctg24_2_Condensation_DCL.1" /domains="nrpspksdomains_ctg24_2_AMP-binding.1" /domains="nrpspksdomains_ctg24_2_PCP.1" /domains="nrpspksdomains_ctg24_2_Thioesterase.1" /final_module /locus_tags="ctg24_2" /monomer_pairings="Leu -> Leu" /tool="antismash" /type="nrps" CDS_motif 1541..1582 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0001" /evalue="3.00E-05" /label="C1_DCL_004-017" /locus_tag="ctg24_2" /protein_end="26" /protein_start="12" /score="15.8" /tool="antismash" /translation="YYLSPMQEGMLFHA" CDS_motif 1604..1720 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0002" /evalue="4.00E-12" /label="C2_DCL_024-062" /locus_tag="ctg24_2" /protein_end="72" /protein_start="33" /score="38.4" /tool="antismash" /translation="FYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIY" CDS_motif 1937..2002 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0003" /evalue="1.70E-11" /label="C3_DCL_135-156" /locus_tag="ctg24_2" /protein_end="166" /protein_start="144" /score="36.5" /tool="antismash" /translation="YHHIILDGWCFGIVVQDLFKVY" CDS_motif 2048..2086 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0004" /evalue="5.50E-04" /label="C4_DCL_171-183" /locus_tag="ctg24_2" /protein_end="194" /protein_start="181" /score="12.4" /tool="antismash" /translation="PYKDYIKWLEKQD" CDS_motif 2324..2419 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0005" /evalue="1.30E-18" /label="C5_DCL_263-294" /locus_tag="ctg24_2" /protein_end="305" /protein_start="273" /score="59.4" /tool="antismash" /translation="DLAFGTVVSGRPAEIKGVEHMVGLFINVVPRR" CDS_motif 2468..2581 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0006" /evalue="4.60E-17" /label="C67_DCL_14fromHMM" /locus_tag="ctg24_2" /protein_end="359" /protein_start="321" /score="54.4" /tool="antismash" /translation="QEQSLQSEPHQYVPLYDIQSQADQPKLINHIIVFENYP" aSDomain 2912..4105 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_2_AMP-binding.1" /evalue="1.30E-112" /label="ctg24_2_AMP-binding.1" /locus_tag="ctg24_2" /protein_end="867" /protein_start="469" /score="368.2" /specificity="substrate consensus: Leu" /tool="antismash" /translation="FKEAVNVNPNAPALTYSGQTLSYRELDQEANRLAHRLQKHGAGKG SVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKE QAAQLPYTGTTLVIDDQTRFEEQESDPATAIDPDDPAYIMYTSGTTGKPKGNMTTHANI QGLVKHVDYMAFSEKDTFLSVSNYAFDAFTFDFYASILNAARLIIADEHTLLDTERLTD LILQENVNVMFATTALFNLLTDAGEDWMKGLRCVLFGGERASVPHVRKALRVMGPGKLI NCYGPTEGTVFATAHVVHDIPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCIS GMGVSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIR" CDS_motif 3098..3139 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0007" /evalue="2.60E-05" /label="NRPS-A_a2" /locus_tag="ctg24_2" /protein_end="545" /protein_start="531" /score="17.4" /tool="antismash" /translation="LGVLKAGAAYLPVD" CDS_motif 3332..3391 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0008" /evalue="1.40E-08" /label="NRPS-A_a3" /locus_tag="ctg24_2" /protein_end="629" /protein_start="609" /score="26.9" /tool="antismash" /translation="AYIMYTSGTTGKPKGNMTTH" CDS_motif 3899..3988 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0009" /evalue="5.50E-13" /label="NRPS-A_a6" /locus_tag="ctg24_2" /protein_end="828" /protein_start="798" /score="41.1" /tool="antismash" /translation="PFGAIGELCISGMGVSKGYVNRADLTKEKF" CDS_motif 4070..4135 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0010" /evalue="9.60E-12" /label="NRPS-A_a8" /locus_tag="ctg24_2" /protein_end="877" /protein_start="855" /score="36.8" /tool="antismash" /translation="YAGRIDDQVKIRGHRIELEEIE" aSDomain 4424..4630 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_2_PCP.1" /evalue="1.50E-25" /label="ctg24_2_PCP.1" /locus_tag="ctg24_2" /protein_end="1042" /protein_start="973" /score="81.1" /tool="antismash" /translation="EETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELG IDLPVKLLFEAPTIAGISAYVKNG" aSDomain 4685..5305 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_2_Thioesterase.1" /evalue="1.10E-36" /label="ctg24_2_Thioesterase.1" /locus_tag="ctg24_2" /protein_end="1267" /protein_start="1060" /score="119.3" /tool="antismash" /translation="IFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLI QKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVES DVEALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVSLISTGQVKADIDLLTSGAAFDM PEWLASWEEATTGAYRMKRGFGTHAEMLQGETLDRNAEILLEFL" CDS_motif 4829..4903 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_2_0011" /evalue="6.30E-10" /label="NRPS-te1" /locus_tag="ctg24_2" /protein_end="1133" /protein_start="1108" /score="31.5" /tool="antismash" /translation="QPEGPLTLFGYSAGCSLAFEAAKKL" CDS 5361..6089 /NRPS_PKS="Domain: Thioesterase (14-231). E-value: 3.7e-55. Score: 179.7. Matches aSDomain: nrpspksdomains_ctg24_3_Thioesterase.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (smcogs) SMCOG1004:thioesterase (Score: 213; E-value: 5.8e-65)" /gene_kind="biosynthetic-additional" /locus_tag="ctg24_3" /sec_met_domain="Abhydrolase_6 (E-value: 2.6e-15, bitscore: 50.3, seeds: 455, tool: rule-based-clusters)" /sec_met_domain="PF00561 (E-value: 1.1e-06, bitscore: 21.1, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAA EPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGI FPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSD YRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQ TEEVAERIFAILNQHPIIQP" aSDomain 5403..6053 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_3_Thioesterase.1" /evalue="3.70E-55" /label="ctg24_3_Thioesterase.1" /locus_tag="ctg24_3" /protein_end="231" /protein_start="14" /score="179.7" /tool="antismash" /translation="QLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIE DLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPH IQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQ IQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIF" CDS_motif 5586..5657 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg24_3_0001" /evalue="1.90E-08" /label="NRPS-te1" /locus_tag="ctg24_3" /protein_end="99" /protein_start="75" /score="26.7" /tool="antismash" /translation="PDRPFVLFGHSMGGMITFRLAQKL" CDS 6191..7417 /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 339; E-value: 5.2e-103)" /gene_kind="transport" /locus_tag="ctg24_4" /transl_table=11 /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADRS LISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFSAI YGVLGGIGYSCAVGVTTQYFISRWFDRHKGLALAILTNANSAGLLLLSPIWAAAPYHAG WQSTYTILGIVMAAVLLPLLVIGMKHPPYAQAESVKKSYDWRGFWNVMKQSRLIHILYF GVCTCGFTMGIIDAHLVPMLKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLGSRSVM LSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISESYQTGL IGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIELVPFLDKQ KAKETHQSI" CDS complement(7432..7989) /locus_tag="ctg24_5" /transl_table=11 /translation="MIQYASESINLPGEISFKDVREIFFYQIAKISCFYFLLFCAIFAA VNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKLKR TYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKRFFHSEVEMN RFKEIILKNTETKKLKFKKDQH" CDS complement(8043..8981) /gene_functions="transport (smcogs) SMCOG1166:transporter, EamA family (Score: 155.9; E-value: 2.5e-47)" /gene_kind="transport" /locus_tag="ctg24_6" /transl_table=11 /translation="MVKHQQASAYTAAILYSFIIGLSFLFVKIALQTAEPFDILAHRFT LAFAAATVPILFGWVKLSIRVKDVIAILPLALLYPALFFSFQAFGLVYSSSSEAGIIQA AIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLILLSA LSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVFTYFLPFREPG FVLAIVYLGVLSSLVTSILSNYTLSRIEAFKMSAFNHVSTIVTMISGVVILNESLAWYH LAGAVCIMIGVVGSNINLEKKTKRPGIPAKK" CDS 9105..10439 /NRPS_PKS="Domain: Aminotran_1_2 (96-438). E-value: 2e-23. Score: 74.9. Matches aSDomain: nrpspksdomains_ctg24_7_Aminotran_1_2.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019:aminotransferase (Score: 263.3; E-value: 6e-80)" /gene_kind="biosynthetic-additional" /locus_tag="ctg24_7" /sec_met_domain="Aminotran_1_2 (E-value: 3.3e-23, bitscore: 75.0, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MEKYMSLVTRIEEMMQSTAYQEGDRLPSIRQMSARYQVSKSTVIR ALQELEKRHLIYSVPKSGYYIVKKTGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCINK AIDTYKNDLFIYGTPKGLPSLIRVLRKLLANQQVFADERHIFITSGVQQALSLLCAMPF PNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAEVERLFQTESIKFFYTMP RFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYL KSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKE KIRDSYKERSLKLHQAIQTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASRVIHRLKK QGVLLEAIDRHYLSDYQKENLLKINISNVKTEDIERGVKLLMSHL" aSDomain 9393..10418 /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_7_Aminotran_1_2.1" /evalue="2.00E-23" /label="ctg24_7_Aminotran_1_2.1" /locus_tag="ctg24_7" /protein_end="438" /protein_start="96" /score="74.9" /tool="antismash" /translation="DFQHCINKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLANQQVFAD ERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEG LDIAEVERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGD LEENKKADPLYAYDLSSHVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDC SMISQAALEIYLKSGMYGRHKEKIRDSYKERSLKLHQAIQTHRQLGSGRFTFSSGQAPC MHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLSDYQKENLLKINISNVKTEDIERG VK" CDS complement(10434..11108) /NRPS_PKS="Domain: ACPS (103-166). E-value: 6e-20. Score: 63.4. Matches aSDomain: nrpspksdomains_ctg24_8_ACPS.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1012:4'-phosphopantetheinyl transferase (Score: 188.7; E-value: 1.5e-57)" /gene_kind="biosynthetic-additional" /locus_tag="ctg24_8" /transl_table=11 /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRTL LGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVIGAFDSQPI GIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSL PLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAAHPDFPEDITIVSYEE LL" aSDomain complement(10611..10799) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg24_8_ACPS.1" /evalue="6.00E-20" /label="ctg24_8_ACPS.1" /locus_tag="ctg24_8" /protein_end="166" /protein_start="103" /score="63.4" /tool="antismash" /translation="IGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWS MKESFIKQEGKGLSLPLD" CDS complement(11213..11860) /locus_tag="ctg24_9" /transl_table=11 /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSLF QHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPAPSTYT GSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTILFA AWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH" CDS complement(12181..12924) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 222.1; E-value: 1.3e-67)" /gene_kind="transport" /locus_tag="ctg24_10" /transl_table=11 /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLR CLNALEIPNRGELAFDDFSIDFSKKVKQTDILNLRRKSGMVFQAYHLFPHRTALENVME GPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELML FDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQG PPEQIFSAPKEERTQRFLNRILNPL" CDS complement(12938..13642) /gene_functions="transport (smcogs) SMCOG1096:polar amino acid ABC transporter, inner membrane (Score: 244.4; E-value: 1.7e-74)" /gene_kind="transport" /locus_tag="ctg24_11" /transl_table=11 /translation="MFLNNLPALTLATAIPWDLVQQSFWPILSGGIYYTIPLTILSFIF GMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSA VIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLS NTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQH VIERRLDRYVAK" CDS complement(13629..14435) /gene_functions="biosynthetic-additional (smcogs) SMCOG1091:glutamine-binding lipoprotein glnH (Score: 234.3; E-value: 2e-71)" /gene_kind="biosynthetic-additional" /locus_tag="ctg24_12" /transl_table=11 /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKG VLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSK RFDVIANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNY NKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGD PQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK" CDS complement(14551..15423) /gene_functions="regulatory (smcogs) SMCOG1014:LysR family transcriptional regulator (Score: 243.3; E-value: 5e-74)" /gene_kind="regulatory" /locus_tag="ctg24_13" /transl_table=11 /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELGV VLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYCAA LMLEKVTQIKERYPHLTFNIWENKPATLLELLESRQIDAAVTTTLIKSDTVQFKQLDDI PCVLVLSDEAGYPCGDTIKMEDIPSFALILLRPVNGKGVYNQVMNEFHRLNLEPRIVCE CHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTDSYLPK PAQQFLDLF" CDS 15513..15677 /locus_tag="ctg24_14" /transl_table=11 /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLFLYNENKGGVRNGT CGDLSLGRL" CDS 15640..16485 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1262:haloalkane dehalogenase (Score: 62.8; E-value: 4.9e-19)" /gene_kind="biosynthetic-additional" /locus_tag="ctg24_15" /sec_met_domain="PF00561 (E-value: 3.7e-15, bitscore: 48.9, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 9.5e-09, bitscore: 28.8, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MERAGICHSDGFDLAYRIEGKGAPILVIGSAVYYPRLFSSDIKQK YQWVFIDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMALEY ARTYPKQVRKVALFNTALDNSEERQRKSESFFMETASLERKKRFEKDIANLPQDIDKDP ERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFAQIDLIQRLADVRM PVYIGLGRYDYLVAPVSLWDAVDGLYPHMDKVIFERSGHQPMLEEPEAFDQSFSKWLDQ " CDS complement(16526..18004) /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 51; E-value: 1.3e-15)" /gene_kind="transport" /locus_tag="ctg24_16" /transl_table=11 /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRAI LLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGGIF IMFGHIALAYPGSAIAFYISMALIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSIFYM GINLGGLLAPLIIGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNVPNPL SKKSAIGTGIGVIIVAIAVMISVQTGVLTINRFIDLVSILGILIPVIYFIIMFTSKKAD KTEKSRLAAYVPLFISAVMFWAIQEQGATILAVYADERIKLSLGGFELQSSWFQSLNPL FVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEALVSPLWLV LSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQVAGLFDKIP ETMYFGTIGLISIVLGGILLLLSPMIKRAMKGVL" CDS 18274..20028 /locus_tag="ctg24_17" /transl_table=11 /translation="MAEFILNAADFGVPGDGKTDSTERINQCLSTAVSKGYHTVWFPKG TYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQENIT ISGGQIIGERDEHTYVSAGIRSTHEWGFGICIEGCSNVLIDDVKISDFTGDGIIVSPRG LKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPKFGID IEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYGYGTQT VIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRGKSVLVT NNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLNNCLIQVV DGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNILNPDAFEAVPESYSVSVTNNAG AIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIFDNTISVNRT AGNPIVIYINGSAGSIVSGNTINNLSADTATAIQTTTSTNSKIIGNRIFKGTINKHSSD TIDGNMIV" CDS complement(20043..20264) /locus_tag="ctg24_18" /transl_table=11 /translation="MKILGVTGVILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTTF AEWVVLLFFVLVLVREIYMIYKSKKKNP" CDS 20390..22024 /locus_tag="ctg24_19" /transl_table=11 /translation="MPLFSKRKNNTGSKDKQNTDERNQEQQQEKERPVLISPSLAKNIA ETKKEVGSSSDVIIREIKIGEQDHVHLAVIYIAGLVDNNTIHESLIDPLVQDESIQNTH AIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSIQEP STQASFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQGICDK KVLKEVKLRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLEGRFAI IVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLIFFISLVAPAVYVAATTF HQEMIPTELLVVIAAQRESVPFPAVVEALTMEVAFEILREAGFRLPRVVGSAVSIVGAL VIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFLIASAVMGFYGLI LGIIMMFVHLCSLRSYGVPYMSPLAPFSSQGVKDTLFRVPWWADEKRPESVSKEDKVRQ GQDQRPEPAASRGMVNKDLEEGDKNGT" CDS 22014..23237 /locus_tag="ctg24_20" /transl_table=11 /translation="MVRKCLLVVLMLLSAIVLPGCWDKRELTDLAIISAIGIDRTNDSN YVLHLQIINPGNVAGGLQGGGDGDRPPVSVYSIEGNNLTEALRKASIKVSRRLYFAHTN LVVINEKLAKEEGLDFVLDNLDRDTEFRSTATFVVAHKTKAENIVKILTPIDKIPSNKV NKTLDFTEAQYGRVVNTNIQDVLKTLAANTMAPVIPGFMMIGDDKKGVSMENTQATDPK AILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTLINADWGKTKDAVSLQVTHQ DTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEKEISHTV KKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRRTGLRNDP IKHQFKDD" CDS 23262..24383 /locus_tag="ctg24_21" /transl_table=11 /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGCA IGLFLFCLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYNAARVLRDFGEM LLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGVMYLLGAIGLVLIIVSG TIDPHNLKPVLANGISPILHSVFTQTMYVPFGEVVLFVMIFPILNNRKDVKKMGMIAMA ISGLVVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALIIGGFF KVSLYLYATVVGTSTLFKEKNLSQLAYPMGLGILILSLTIATNFSEHLNEGLNVVPLYI HLPFQLLFPLFLFIVAVWKKKRREKSKGTGIKE" CDS complement(24488..25168) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 172.5; E-value: 1.9e-52)" /gene_kind="transport" /locus_tag="ctg24_22" /transl_table=11 /translation="MSLLEFQQVGYWYKDKSQSLFQDINISFQKGKFYTIVGTSGTGKT TFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVTTA MEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDLIVA DEPTGNLDEDTSKEIVRLFQDLAHKENKCVIMVTHDEQIAKVSDINIRLSRGSFTVKEN VAVV" ORIGIN 1 gacgatcgaa gagcttaccc aatatgtaga gcgtgccgaa ggcaaacagg cagaccaagg 61 cccggtggag ggcgaagtca tcctgacgcc gatccagcgc tggttctttg aaaagaactt 121 cacgaacaag caccactgga accaatctgt gatgcttcac gccaaaaagg gctttggtcc 181 tgaacgggtg gagaaaacat tgcaggcgct gatcgagcat catgacgcgc tccgtatggt 241 ctatcgtgag gaaaacgggg acatcgttca ggcgtataaa ccgatcggtg agagcaaggt 301 cagcttcgaa atcgtggatc tgtacggctc tgatgaagag atgctgagaa gccagattaa 361 gattctcgcg aacaagctgc aaagcagtct cgatctgaga accgggccgc ttttaaaggc 421 ggagcaatat cgcacagaag ctggggatca cctgctcatt gctgtacacc atctcgtggt 481 cgacggtgtg tcatggcgga ttttgcttga agactttgct tcaggctaca tgcaggctga 541 gaaagaagag agccttgtct tcccgcaaaa aacaaactcc ttcaaggact gggcggaaga 601 actggcggca ttcagccaat cagcgcatct tttacagcag gctgaatact ggtcgcaaat 661 tgccgctgaa caggtttctc ctttaccgaa ggattgtgaa acagagcagc ggatcgtcaa 721 ggatacatca tccgtcctat gtgaattaac ggaagaagac acgaagcatc ttttaacaga 781 tgttcatcag ccatatggta ctgaaatcaa cgatattctt ctcagcgcgc tcggtttgac 841 aatgaaagaa tggacaaagg gtgccaaaat tggcattaac cttgagggac acggccggga 901 ggatattatc ccgaatgtga atatctccag aacggtcggc tggtttacgg cacaataccc 961 tgttgtgctc gacatatctg aagcagatgc ctcagctgtg atcaaaacag tcaaagaaaa 1021 cctgcgccgc attccggaca aaggtgttgg ctacggcatt cttcgttatt tcacagaaac 1081 agcggaaaca aagggcttca caccggagat cagcttcaac tatttgggcc aattcgacag 1141 cgaagtcaaa accgatttct ttgaaccgtc cgcattcgat atggggcgcc aagtaagcga 1201 ggaatcagag gcgctgtacg cattaagctt cagcggcatg atcagaaacg gccggtttgt 1261 gctttcctgc tcctacaatg aaaaggagtt tgaaagagcc acgattgaag agcgaatgga 1321 acggtttaaa gaaaacctcc tgatgctaat tcgccattgc acggaaaaag aagacaagga 1381 attcacacca agcgacttca gcgccgaaga ccttgaaatg gacgagatgg gagatatctt 1441 tgacatgctt gaggagaatt taaaataaaa cgcaagggaa ttacagaagg cgggagcgaa 1501 acatatgagt caatttagca aggatcaggt tcaagatatg tattacctat cgccgatgca 1561 ggaagggatg ctttttcatg ccatcctgaa tcccggccaa agcttttacc ttgaacaaat 1621 cacgatgaaa gtaaaaggca gcttgaatat caaatgtctt gaagaaagca tgaatgtgat 1681 catggaccgg tacgatgtat ttcgtaccgt gttcatttac gaaaaagtaa aaaggcctgt 1741 ccaagtcgta ttgaaaaaac ggcagttcca tatagaagaa atcgatctga cacacttaac 1801 gggcagcgag caaacagcca aaatcaatga gtacaaagaa caggataaga tcaggggttt 1861 tgatttgacg cgggatattc cgatgcgggc agccattttc aaaaaagctg aagaaagctt 1921 tgaatgggtg tggagctacc accacattat tttggacgga tggtgcttcg gcatcgtcgt 1981 acaggatcta tttaaggtat acaatgctct gcgcgaacaa aagccgtaca gcctgccgcc 2041 cgtcaaaccg tataaagact acatcaagtg gcttgaaaag caggataaac aagcatcact 2101 gcgttactgg cgcgagtatt tagaggactt tgaaggacaa acgacgtttg cggagcaaag 2161 aaagaaacaa aaggacggct atgagccgaa agagctgctc ttttcactgc cggaggcgga 2221 aacaaaggct tttaccgagc ttgcaaaatc gcagcatacc actttaagta cggcgctgca 2281 ggcagtctgg agcgtattga tcagccgcta tcagcagtct ggcgatttgg ccttcggtac 2341 agttgtttca gggcgtcccg cggaaatcaa aggcgttgaa catatggtcg ggctgtttat 2401 caacgttgtc ccgagacgtg tgaagctgtc tgagggtatc acatttaacg gcttgctcaa 2461 gcagctgcag gagcaatcgc tgcagtctga gccgcatcaa tatgtgccgc tttatgacat 2521 ccaaagccag gccgatcagc cgaaactgat taaccacatc attgtttttg agaactatcc 2581 gcttcaggat gcgaaaaatg aagaaagcag tgaaaacggc tttgatatgg tggatgttca 2641 tgtttttgag aagtcgaatt atgatctcaa cctgatggct tcccctggag atgagatgct 2701 gattaagttt gcctataatg agaatgtgtt tgatgaggcg tttatcctgc gcttgaaatc 2761 tcagcttctc acagcaattc agcagctcat ccagaatccg gatcagcctg tcagcacgat 2821 caacctcgtt gacgacaggg agagagaatt tttgctaacc ggcttaaatc cgccggctca 2881 aactcatgag acaaagcccc tgaccgattg gtttaaggaa gcggtgaatg tcaatccgaa 2941 tgcgccggcg cttacgtatt ccggccagac cctgtcttat cgcgaattag atcaggaagc 3001 gaaccgcctt gcgcaccgtt tgcaaaaaca cggtgcgggc aaaggctccg ttgtagcgct 3061 gtacacgaag cgctcacttg aactggtgat cggcattctc ggtgtattaa aggcaggagc 3121 ggcttatctg ccggttgacc cgaagctgcc agaggaccga atctcgtata tgctggctga 3181 cagtgcggca gcctgtctgc tgacacatca ggagatgaaa gaacaggcgg ctcagctgcc 3241 gtatacaggc acaacgctcg tcatcgatga tcaaacacgg tttgaagaac aggaaagcga 3301 tcctgccacc gcgattgatc ccgatgatcc ggcatatatc atgtacacgt ccggcacaac 3361 cggaaagcca aagggcaata tgaccactca tgccaatatt caagggttgg tcaagcatgt 3421 agactacatg gcattttctg aaaaagatac gttcttatct gtttcgaatt acgccttcga 3481 cgcatttacc tttgatttct acgcttccat actgaatgcg gcacggctca ttatcgcaga 3541 tgaacatacg ctgcttgata cagaacggct cacagatctg atcctgcaag agaatgtcaa 3601 tgtcatgttt gcgacaaccg cactatttaa tcttctcaca gatgcgggag aggattggat 3661 gaaggggctt cgctgtgtat tattcggcgg agagcgcgca tctgtgccgc acgtcaggaa 3721 agcgctgcgg gtcatggggc cgggcaagct gattaactgc tacgggccga ctgagggaac 3781 agtgtttgcg actgctcacg tcgtgcatga tataccggat tccatctcct cattgccgat 3841 cggaaagccg atcagcaatg ccagtgttta tattctgaac gagcaaagcc agctccagcc 3901 attcggggcg atcggtgaac tgtgcatcag cggaatgggc gtgtcaaaag gatatgtaaa 3961 tcgtgctgac ctcacgaagg aaaagtttat taagaacccg ttcaagccgg gagaaacgct 4021 ttaccgcaca ggggatttag cgcgctggct gccggatgga acgattgaat acgccggccg 4081 tattgacgat caggtcaaaa tacgcggaca ccggattgag cttgaagaaa ttgaaaagca 4141 gctgcaggaa tacccaggtg tgaaagatgc agtcgttgtg gcggaccgcc atgagtctgg 4201 cgatgcatca atcaatgcct acctcgtgaa ccggacgcag ctttcagctg aggacgtgaa 4261 ggcgcacctg aaaaaacagc ttcctgctta catggtgccg caaaccttta ccttcttgga 4321 tgagcttcct ttaacgacga acgggaaagt caataaacgg ctgctcccaa aacctgatca 4381 ggatcagctg gcggaagaat ggatcggacc gcggaacgat atggaagaaa caatcgcaca 4441 aatctggtcg gaggttctcg gcagaaagca aattggcatt catgacgatt tctttgcgct 4501 cggagggcat tccttgaagg ccatgaccgc cgcttcccgc atcaagaaag agctcgggat 4561 tgatcttcca gtaaagcttt tgtttgaagc gccgacgatc gccggcattt cagcgtatgt 4621 gaaaaacggg ggccctgatg gcttgcagaa tgtaacgata atgaatcagg atcaggagca 4681 gatcattttc gcattcccgc cggtcttggg ctatggcctt atgtaccaaa atctatccag 4741 ccgcttgccg tcatacaagc tgtgcgcctt tgattttatt gaggaggaag accggcttga 4801 ccgctatgcg gatttgatcc agaagctgca gccggaaggg cctttaacat tgtttgggta 4861 ttcagcggga tgcagcctgg cgtttgaagc tgcgaaaaag cttgaggaac aaggccgtat 4921 tgttcagcgg atcatcatgg tggattccta taaaaaacaa ggtgtcagtg atctggacgg 4981 acgcacggtt gaaagtgatg tcgaagcgtt gatgaatgtc aatcgggaca atgaagcgct 5041 caacagcgaa gccgtcaaac aaggcctcaa gcaaaaaaca catgcttttt actcatacta 5101 cgtcagcctg atcagcacag gccaggtgaa agcagatatt gatctgttga cttccggcgc 5161 tgcttttgac atgccggaat ggcttgcatc atgggaagaa gctacaacgg gtgcttaccg 5221 tatgaaaaga ggcttcggaa cacacgcaga aatgctgcag ggcgaaacgc tagataggaa 5281 tgcggagatt ttgctcgaat ttcttaatac acaaaccgta acggtttcat aaaagaagtg 5341 atgaaaggag gagacagcca atgagccaac tcttcaaatc atttgatgcg tcggaaaaaa 5401 cgcagctcat ctgttttccg tttgctggcg gctactcggc gtcgtttcgc cctctccatg 5461 cttttttgca gggggagtgc gagatgctcg ctgccgagcc gccgggacac ggcacgaatc 5521 aaacgtcagc cattgaggat ctcgaagagc tgacagattt gtacaagcaa gaactgaacc 5581 ttcgccctga tcggccgttt gtgctgttcg gacacagtat gggcggaatg atcaccttca 5641 ggctggcgca aaagcttgag cgtgagggca tctttccgca ggcggttatc atttctgcaa 5701 tccagccgcc tcatattcag cggaagaaag tgtcccacct gcctgatgat cagtttctcg 5761 atcatattat ccaattaggc ggaatgcccg cagagcttgt tgaaaataag gaggtcatgt 5821 cctttttcct gccttctttc cgatcagatt accgggctct tgaacaattt gagctttacg 5881 atctggccca gatccagtcg cctgttcatg tctttaacgg gcttgatgat aaaaaatgca 5941 tacgagatgc ggaaggctgg aagaagtggg caaaagacat cacattccat caatttgacg 6001 gaggacacat gttcctgctg tcacaaacgg aagaagtcgc agaacggatt tttgcgatct 6061 tgaatcagca tccgatcatt caaccgtgat caaaagcgga cagcttcggc tgttccgctt 6121 ttttttgtgt tgaatgccaa ttttcgcatg gtataatagt cgaaatactc aaataaaggc 6181 aggtcgaaac atgcgcacgt ctcccaggat gaaatggttt gtattgctgt ttacgtttgt 6241 tttcgccatc ggaatgaact cattcagaaa ttcctttcaa ttttttatgc tgccaatggc 6301 ggatgccttc catgccgaca ggtcgctgat ttcggtttct gtcagcattt ttatgatcac 6361 aaccggcatc gtccagtttt ttgtcggttt tttcatcgac cgtttcagtg tcagaaaaat 6421 tatggcgctt ggagctgtct gcatcagcgc aagctttttg gtgcttcctt attcaccgaa 6481 tgttcatgtg ttttccgcca tttacggtgt gcttggcgga atcggatact cctgcgcggt 6541 cggcgtgacg acccagtatt tcatcagccg ttggtttgac agacacaaag gtctggcgct 6601 tgctattttg accaatgcca actctgcggg cctgctgctt ctctcgccca tttgggctgc 6661 ggctccgtat catgccggct ggcagagcac ctatacgatt ttgggaatcg tcatggcggc 6721 tgttctgctg ccgctcctcg tcattgggat gaagcacccg ccgtatgcgc aagcggagtc 6781 tgtgaaaaaa tcttatgatt ggcgggggtt ttggaacgtg atgaagcaat cccgcctcat 6841 tcatatcctg tacttcggcg tgtgtacttg cggatttacg atgggaatca ttgatgctca 6901 tctcgttccg atgctgaagg atgcacatgt ctctcatgtc aacggaatga tggccgcgtt 6961 cggggcgttt attatcattg gcggattatt ggcaggctgg ctgtccgatc tcctcggcag 7021 cagaagcgtc atgctatcca tcttattttt cattcggctg ctcagcctca tttgcctgct 7081 cattcccatt ctcggaattc atcacagcga cctttggtac ttcgggttta tcctgttatt 7141 cgggctcagt tacacaggcg tgatcccgct gaccgcggcg tcaatttcgg aaagctatca 7201 aacaggattg atcggatcgc tgttaggcat caatttcttt atccatcagg ttgccggagc 7261 tctcagcgtg tatgcgggcg gtttgttttt tgacatgact catggttatt tgctgattgt 7321 cgctgtgtgc atcgtgtttg tgggtttatc ggctgtaata gagctggtgc cgtttttaga 7381 taaacaaaag gcaaaagaaa cccaccaatc aatataaaag gatcagcact gtcaatgctg 7441 atccttttta aatttgagtt tttttgtttc ggtattttta aggataatct ccttgaatct 7501 gttcatctcc acttcggaat gaaaaaaacg ttttgggatc gcaatatatt ggccacttga 7561 tgtattgacc ctgaagatat ttttatattc gaaaacagcc gtgatttcat cccaattgaa 7621 aatgaggtca tattttttag aacatatacg aattccttct tggttcagag tatatgttct 7681 tttcaatttc atccgttcgt tcttcttgta tgctctggaa aacttcacat atagaagaag 7741 gaggagcagc agtgtaaaca gaacggacat cacgataatc aacatactgt tcataaacaa 7801 gttaagcgcg tcactgccat aaacgatacg gggccatccg ttaatgaagt taactgcagc 7861 aaatatggcg caaaacaaca gaaagtaaaa gcatgatatt tttgcgattt gataaaaaaa 7921 gatttctctt acatccttaa aagagatttc tcctggaaga ttgatacttt cactagcata 7981 ttgaatcata cgataaactt acacctctaa ccatgttttt cctttcagtc tagcataatt 8041 tctcattttt ttgcaggtat accagggcgc tttgtttttt tctccagatt gatattgctc 8101 cccaccacgc caatcataat acaaacagcc ccggcaagat gataccaggc caggctttcg 8161 ttgagaatca caactcctga aatcatcgtc acaatggtag atacatgatt aaaagcactc 8221 attttaaacg cctcaattcg cgacagcgta tagttagaca gaattgaagt gacgagtgaa 8281 gacagcacgc ccaaatacac aatggcgaga acgaagcctg gctcccggaa cggcagaaaa 8341 taagtgaaga ctgttcccgc cgctccgtga cgcacaaggg cgatggcgtt gaagacgaca 8401 aagccgatgg ctgacatgat gtaggtgagc tcggtcagct tgaaccgctg cgtcattttt 8461 ctggcagcag tattgtacat cgctgaagac aaagcggaca ataggatcag caaagaccct 8521 tttaagctgg ctgattccac gtcaacgcct ttcatcacaa aaataaacat gacgccggca 8581 acggataaaa ccgtgaaccc tttttgcgtc cacgttgggc gttcctttaa aacataagcg 8641 gcaaagacca tcgtgaaaat cggaatggct gcctgaataa ttcccgcttc agaggaggac 8701 gagtacacaa ggccgaatgc ctgaaagctg aaaaataacg cgggatacag cagggcgagc 8761 ggcaaaatgg caatgacgtc ctttacacgg attgatagct ttacccagcc gaataagatc 8821 ggtacagtcg ccgcagcaaa cgcaagggtg aaccgatgcg ccaaaatatc aaacggctct 8881 gctgtttgca gtgcgatttt tacgaataga aaggataaac cgataatgaa cgaatataag 8941 atagccgccg tataagcgga ggcttgctga tgtttaacca taatgggaag tgctccttta 9001 cctgaattgc agcgccggtc gctctcttta ttgtatgacc gcggtcagaa cggtacaatg 9061 agaaaaacaa tgaactgtac cggtacaaaa cagggggaga aggcatggag aaatatatga 9121 gtctagtaac gaggatagag gagatgatgc aaagcaccgc ctatcaagaa ggagacaggc 9181 ttccatctat ccgtcagatg tccgcccgct accaagtcag caaaagcaca gtgatccgcg 9241 cgctgcagga gctggaaaag cgccacctta tctattctgt tccgaaaagc ggctattata 9301 ttgtgaaaaa gacagggaaa tcaaaaagcg ggcagcctgg ccccatcgac tttgccacat 9361 ctgcgccgga tccagatgtg tttccgtatc ttgattttca gcactgtatc aacaaagcga 9421 ttgatacata caaaaacgat ttgtttattt atgggacgcc aaaggggctt ccatcactca 9481 tccgtgtact ccgaaagctc ttggccaatc aacaggtatt tgcggatgaa cggcatattt 9541 tcattacatc aggtgtccag caggcgttat ctctgctttg tgccatgccg ttcccaaatg 9601 ggaaagagaa gatcgccatt gaacagccgg gctaccattt gatggtcgaa cagcttgaga 9661 cgcttgggat tcccgccatc ggggtgaaac gaacggaaga gggacttgat atagccgagg 9721 ttgagcggtt atttcaaaca gaatcgatta aattttttta tacgatgccg cgcttccata 9781 acccgcttgg ctgctcattg tcagagcgtg ataaacagga gcttgtgaga ctggcagaag 9841 cgtatgatgt ctatctcgtt gaggatgatt acctcggtga tctggaggaa aataaaaagg 9901 cagatccgct gtacgcatat gatctgtcct cacatgtcat ctatttgaaa agcttctcga 9961 aaatgatgtt ccccggcctt cgcgtggggg cggctgtttt gcccgaagcg ctgactgaca 10021 cgttctatgc gtacaaaaag ctgaacgaca tcgactgttc gatgatttct caagcggcat 10081 tggagattta cctgaaaagc ggtatgtacg gcaggcataa ggagaaaatc agagattctt 10141 ataaagagcg gtcgctgaag cttcatcaag ccattcaaac acacaggcag ctgggaagcg 10201 gccgctttac gttctccagc gggcaggcac cctgcatgca cacccacctg gtgcttcctc 10261 aggatctgcc cgcctcaaga gtgattcata gactgaaaaa acaaggggtt ctccttgagg 10321 cgatagaccg tcattattta tcagattatc agaaagaaaa tctattaaaa atcaatattt 10381 ccaatgtgaa aacggaagat attgagcgcg gtgtcaagct gttgatgagc catttataaa 10441 agctcttcgt acgagactat tgtgatatcc tcggggaaat cagggtgtgc ggcgcataca 10501 gccattttgt agccgggatc gacctcatac gttttgatat agcatgggga atggctgtcc 10561 ggaagctcaa tggatacttg tccgtcctgg tgcaggcgca ctgaaaagga atcaagcgga 10621 agcgataagc ctttgccttc ctgtttgata aagctttctt tcattgacca tagatgataa 10681 aaatagtctg tctgctcgtc cttgtctttt gctaaaaggt cgctgtactc tgtttttgaa 10741 aagaagcgct tggcgatctc aaggctgatc ggtttcgttt tttcgatatc tatgccgatc 10801 ggctgtgaat caaacgcacc aatgacccag cggccggagt gagaaatgtt gaaatgagcg 10861 tcgggaagat cagggatgca cggcttcccg tattcctgcg tgctgaagcg gatatcggat 10921 ttgtccaact gatactgcct gcttatgact gagcgaacga gcacatctcc cagcagggtg 10981 cggtgagcat cttctttatg ataaaatctc cggcatttct cccgtttttc aggtgatatg 11041 aaagacatga accgttcatt ttcttcctgt gaaagcgggc ggtccatata aattccgtaa 11101 atcttcattc tagatcctcc gtctgcaaaa gattgtcaaa accatcctat catacttcca 11161 caagactcat atagaggaga aaataaaaaa acaaagccaa ggcggctttg ttttagtgta 11221 caggcggaga tgctttcaca gcggctgtcc gccttgccac agcataattc agcaactgga 11281 ttgactgcgg caatgaaaaa cgcagaatga gtccggtgag gatggcggtc aaaatggtgc 11341 caaaaccgat cggtccgccc atgccccatg ccgcaaacaa aatggttaat tccatgccgt 11401 tccgcaccca ttgcacattc cagccggttt tttctgtaat cagcatcatc agtgaatcac 11461 gcggccccgc gccaaggcct gctgatacat aaacaccgac gccgtaacca atcagcacca 11521 cgcctagaga gaagacgatg atcgagcctg tgtaggtcga gggggcaggc agaatgaaat 11581 tgaaaaaatc tataaataca ccaatgagca ccatattcag gagggcccca attttcggcc 11641 aagctctcgt aaacaatgac gtgaatccga cgatgagcgc tccaataatg atggaccact 11701 ggccgacggt aagcccgaag tgctgaaaca ggctgtaatg aaatgcatcc cacggactaa 11761 tgccgagtgc ttttccttct atcgtcaggg atacaccaaa agccaaaatg atcaaaccgg 11821 caaaataaaa tgtccagcgc agaacaagtt cttgcttcac gtgaggtccc ttctttcgta 11881 aaaatcagtc gattgtcatt gtagcacatc tgacagaagg gcggaatagg cgaaaggggc 11941 tcaacaaaaa aacagggccg ccgccggcgc cctgtttcag cgtgttggca aacccttgca 12001 ttcgttgtca ggcctgcgct tcggtgctca cgaatttaac attcgatgtg ctccaatgct 12061 cgcccttcct agacttcaaa ggttttcaat cacgctgaaa atgacaaaat cctaaaacga 12121 aaatcgtttt aggattttgt caataatctg aaacagggcg ctgacgccct gtttttctta 12181 ttacagcggg ttcaaaatcc ggttcaagaa ccgctgtgtc cgctcttctt ttggtgcgga 12241 gaaaatttgc tccggcggtc cctgctccac gataacgccg ccgtcgatga agatgacttc 12301 atccgcaact tcctgcgcga acttgatttc gtgggtcacg acgaccatgg tccagccttc 12361 attggccaag tccttgataa ccttcagcac ctctccgaca agctcgggat caagcgctga 12421 ggtcggttcg tcaaacagca tgagctcagg ctgaatcgcc agtgcgcggg cgatgccgac 12481 gcgctgctgc tggccgccgg aaagctggaa cggatataaa tccattttgt ccttcaatcc 12541 gactttatca agaagctgaa tcgcttcttt tctgacttcc tctttgttcc gtttttgcac 12601 ctgaacaggg ccctccatca cgttttcgag ggctgtgcgg tgcgggaaca ggtgatacgc 12661 ctgaaacacc attccggatt ttcggcgaag atttaggata tccgtctgtt tcaccttttt 12721 ggagaaatcg atggagaaat catcaaatgc aagctctccg cgattcggga tctccagagc 12781 gttcaggcag cggagcagcg tcgttttccc tgaacctgaa ggcccaagta tggcgatgac 12841 ttttcctttt tcaatcttca tatctatctt ttttaaaatt tcattttcac cgaatgattt 12901 gtttaatcct ttaacggtaa gcatactcgg aacctcctta tttggccacg tagcggtcaa 12961 gacgccgttc gatgacatgc tggacgagtg aaagcaggaa gcagataatc caataaataa 13021 aggctgcttc aatatagatc actaaaattt gatcaagatt ccgcgcgccg atttcctggg 13081 cttttctgaa cagctcagcg accagaattt gagaggcgag ggatgtatct ttaatcaggc 13141 tgataaaggt attggataat ggcgggatcg acacacgaaa cgcctgcggc aaaatgacgc 13201 ggaacagcgt tttttgatgt gtcatgccaa ttgtgtagcc ggcttcccat tgccctttcg 13261 gcacggataa aatagatgcc cgaatgattt cagatgcata ggcgccgacg tttaatgaaa 13321 aggcgataac tgcgcttgga aatggatcta atgtgacgtt aaaggccggg aacagataga 13381 aaatgatgaa caattgaacg agaagaggag tgccgcgtat tgcggatacg tatacgctga 13441 acacccatct caaaggtctc actttcgaca ttctggcaag cgccgtaatc agcgccagga 13501 tcattccgaa tataaaggaa agaatcgtaa ggggaatcgt atagtagatt ccccctgaaa 13561 gtatcggcca gaatgactgc tgcaccagat cccacgggat cgccgtggca agcgtcaatg 13621 ccggcagatt atttagaaac atcttcaccg aaccattttt tagaaatttt agaaagagtc 13681 ccgtcctctt tcatttcttt taatgctttg ttgacttgat caacaacctc gccgcttcct 13741 ttacggaacg tgaaatatgt tgactgagga tcacctgttt caaacgcgat tttcacgttt 13801 ttattgccag atgtttttaa gtagttcaat acggcaagtt tatcgttgta tgtcatatcg 13861 acgcggcctt gctggatcat ttgaagggcc tgcgccatac cttcaacgcc ttctacttta 13921 gcgccggcat ttgtagctaa tttgttgtag ttgcttgtca gtgattgagc tgatgttttt 13981 ccttttacat ctgcttctga cttaatatcg ttgttgtctt ttttcgtaac gacaacggct 14041 cttgatgttg tgtatttatc tgagaaatca tatttgtctt cacgatctgt ttttccgact 14101 tggttggcaa tgacgtcaaa ccgtttggaa ttcaggccgg caaacatgct gtcccattgt 14161 gtttccttaa agtcgacttt aagcccgagg cgttttgcga cttctgtgat aacttcgaca 14221 tcatagccag tcagtttatc agtgtctttg tcgtggtaag tgaacggctc atatgttcct 14281 tccgttccga ctgtgagcac accttttttc ttaattgaag cccaaagatc gccatctttg 14341 gcattatctt ttgactgatt gtcatttcct gctccgcaag ctgcaagagc tgcaatactt 14401 acgaccatga ataaagccaa taatgctttt ttcatcttat tccccacttt tctggttgat 14461 tttattgaaa taaaaaaata gcttacaaat ctaaaggata actttttttt agtatgagtc 14521 aagtaattgg ttttcataag gcaaaatctt ttaaaataaa tccaaaaatt gctgtgccgg 14581 tttaggcaaa taactgtccg ttctccacat gacagccggt gtcataatga agggattatt 14641 ttcgatatgg acggtgtgaa cgtgatttct catatgaacg ggaatcattg tgacaggcaa 14701 aatagacgcg ccgaatccgg atgacacgag gctgagcaaa gttgcagagt cgtggcattc 14761 acaaacaatg cgcggctcca ggttcaaacg atgaaattca ttcatgacct gattataaac 14821 gccttttccg ttgacaggcc gcagcaggat cagcgcaaat gaaggaatgt cctccatctt 14881 aatggtgtct ccgcacggat atccggcttc atctgaaagc acgagcacac atggaatgtc 14941 atcaagctgc ttgaattgta ctgtgtcact cttgatcagt gttgtcgtga ccgccgcatc 15001 gatttgccgg ctttccagca gttccaacag tgtcgcgggt ttattttccc aaatattaaa 15061 ggtgagatgg gggtatctct ctttgatctg tgttactttt tcaagcatca gagccgcgca 15121 ataaatcgtt gatcccacgg caagtgtacc ggctacttcc tccttcagct cctgtacctc 15181 aatgactgca tcttcaaacc tatgcagaat ctcttttgct ctttttagaa aaacagctcc 15241 ttcatatgta agagtcattt gttttttctt gttccggtca aacagaacaa caccaagctc 15301 gtcctccagc tgtttgagct gcctgcttaa aggcggctgc gccatgtgaa gctttttggc 15361 tgcggacgtg attttctgtt cttgggcaat ggtaatgaag tatcgaagct ggcgaatatc 15421 caaaagaaag cgcctcctta tcataccttt taggtattaa atatagattt aatagatatt 15481 tttcatatgg atatatcagg agtatgattg gaatgaaagc agaattcaag cgtaaaggag 15541 ggggcaaagt gaaactcgtt gtcggaatga caggggcaac aggggccatt tttggggtca 15601 ggcttttttt atataatgaa aacaaagggg gcgtgagaaa tggaacgtgc ggggatctgt 15661 cactcggacg gctttgattt agcttatcga attgagggca agggcgcacc catccttgtg 15721 atcgggagtg cggtttacta tccgcgcctt ttttcctcag atatcaaaca gaaatatcaa 15781 tgggtcttta tcgaccatag gggatttgct aagcctaagc gggagctacg tgcggaggat 15841 tcgaggcttg atgccgtctt ggctgatatc gaaaggatga gaacatttct tcagcttgag 15901 gatgttacta tcctgggaca ttccgggcac gcttttatgg ctttagagta tgccaggaca 15961 tatcccaaac aagttcggaa ggtggcgctc ttcaatactg cgcttgataa cagtgaagaa 16021 agacagcgaa aaagcgaatc atttttcatg gaaacagcca gccttgagag aaagaaacgc 16081 tttgaaaaag acatcgccaa tttgccgcag gacatcgaca aagatcctga aaggcgcttt 16141 gtgcacatgt gtattcgcgc tgaagcaaaa agcttttatc aagagcggcc gcatgcagct 16201 gccttatggg atggcgtatt cacgaatatg ccgatcattg atgaattatg gggcaataca 16261 tttgcccaga ttgatcttat tcagcggtta gctgatgttc gtatgccggt gtatatcgga 16321 ttagggagat atgattattt ggttgcgccc gtttcgctat gggatgctgt tgacggttta 16381 tatccccata tggataaggt tatttttgaa aggagcggcc atcagccgat gctggaagaa 16441 ccggaagcct ttgatcaaag cttcagcaaa tggctggatc aataaaaaaa cagcccgcag 16501 atcaaaatcc gcgggctgtt tctgattata agaccccttt catcgcgcgt ttgatcatcg 16561 gcgagagcag caggagaatg ccgccaagaa cgatagaaat caaaccgatg gtgccgaagt 16621 acattgtttc aggaatttta tcaaacaatc cggctacttg ggcattgatc gcttgggctg 16681 ctgcgttcgt cagaaaccac atactcattg tctgtgcaga gaaggcagct ggtgccagtt 16741 tcgttgtcac ggataaaccg actggagaca ggcacagctc tccaagcacg acaagcagga 16801 agctgagaac aagccaaagc gggcttacga gtgcttcttt tccttgcata gcagggaata 16861 ccataatgat aaatgacaat ccggctaaaa taattccgat tgagaattta actggtgtag 16921 acggctggcg tttgccaagc ttcatccaga gccatgcgaa tattggcgca aaaatgacga 16981 caaacaatgg atttaatgat tggaaccaag atgactgaag ttcgaatccg cccaatgaaa 17041 gttttatgcg ttcatcagcg tataccgcaa gaatggtcgc tccctgttcc tgaatggccc 17101 agaacatgac agcactgata aacaaaggaa cgtaagcggc aagacgggat ttttctgttt 17161 tgtccgcttt tttgcttgta aacatgatga tgaaataaat gacaggaatc aaaataccga 17221 gaatacttac aaggtcgata aaacgattga tcgtcagcac gcctgtttgt acagagatca 17281 tcactgcgat cgccacaatg ataacaccga ttccggtgcc aatcgcagat tttttagaca 17341 gcggattcgg cacattggaa cctgcaagcc cgaggttttt ctttcttgtc aaagcaaata 17401 cgataagtcc gagaagcatt ccgaccgcgg cagctccgaa gccgagatga tagttgtact 17461 tctgtccgag tgttccgata attaacggcg caagtaaacc accgaggtta atccccatgt 17521 agaaaatact gaaacctgag tcgcggcgcg ggtcttcttt cgtgtaaaga tccccaacca 17581 cgcttgaaac gtttggtttt aataagcctg ttccgacaat aataagcgcc atgctgatat 17641 agaatgcgat cgcgctgccc ggataggcga gtgcaatgtg gccgaacata atgaatatgc 17701 cgccgtaaaa cacggtgttt gcggtaccga atacccggtc agcgagccat ccgccaataa 17761 tagtggacat gtatacgagt gatccgtaga tcgacataat ggcaaccgca gtgcccttgt 17821 caaagccgag ccctccgttt accgtctctg tatacaaata gtaaagtaag attgctctca 17881 ttccatagta agagaaacgc tcccaaaatt cggtgaaaaa tagtgtaaat agtcctcgcg 17941 ggtgaccaaa gaaccctttt tgcgggacgc ttttaatgat actttcgtta tcaatcgaag 18001 ccatgtcagc caaacccttt ctaaaaaaag tgtattataa aaatcatatt cttatataat 18061 acttgtgtca atataattta tactcatttc aaatagttcc ataatggaaa aattataaat 18121 acctaaaaat agtgattttc tcctaatttt tatactcttt atcgtgagat tttcttacat 18181 aactattcct ttaataaaat tttagagaaa tgtacaagca gatcgggcct ttgtgagtaa 18241 cataatagta atcatagaga aggaggctcg caaatggctg aattcatatt aaatgcagcg 18301 gatttcggtg ttcctggaga tggtaaaacg gattcgacag aacggattaa tcagtgcctc 18361 agtacagctg tttcgaaagg ctatcatact gtctggtttc caaagggaac atatttaata 18421 gacgcaacgc ttggcggaga tcttaatcag aggtttcgaa acgcggggat cattgttccc 18481 ggcaaccttg agattatgat ggaccccgaa tgtatcatga aagtgatacc gaatagttcg 18541 tggggttatt ccgcatttta tgtaggcaag caagagaata taactatttc cggaggacaa 18601 attatcggcg aacgggatga gcatacgtat gtctcggcgg ggataaggtc aacccatgaa 18661 tggggctttg gcatatgtat tgaaggatgc tcgaatgttc tcattgatga tgtgaaaatt 18721 tccgatttta ccggcgatgg gatcatagtc agcccaaggg gattaaagac caatcaagat 18781 tatcgaacgt cagagcaaat tatcatccgc cgctgtgagg ttcggcggtc gaggagaaat 18841 aacatttcca ttaccggatg tgacatggtc acggtggagg agtgcttgat tgaagatgcc 18901 ggaacgggga atggaacagc cccgaaattc ggaattgaca ttgaaggata tggcgaaggt 18961 gacgttgatt atgaggaacc gattaatgta tcaattcgca ataaccactt tgttggaaac 19021 gtttcaagtt ctgtgaccaa ttttaacggg tatggcattt taatagaagg aaatcactct 19081 gacaatacaa tcagctacgg atatgggacg caaacagtga tcaagggaaa tatactgagg 19141 cgccctgaag acgcggcggc tgcgccaaga gtcgggataa ccggactcgg tgtatcacaa 19201 ggaaaagaga ccagtgatgc agtgatcgct ggcaacctca ttaccggatt ttcaactgga 19261 attgatgtca ggggaaagag cgttcttgtg acgaacaaca aaatcagcaa ctttgaaaac 19321 acagggatat tggtttatca gtcttccgac gtaaaggtag acggaaacca aattcaaaac 19381 ggactgtctg aaacaaggcg cagcatcggt cttcgcgcag tgctgtcaga tgacatcgct 19441 tttctgaata actgtctcat tcaagtcgtt gacggtgtga acgtttccgg cggaaatatg 19501 atcattaaag ataatctcct gagaaaattc agccggggca tttggattgc tcaagggaac 19561 gcggtgattg aagggaatat actgaatcct gacgcgtttg aagcagtgcc ggaatcatat 19621 tctgtttccg tcacaaacaa tgccggcgcc atcatcaaaa acaatacatt taaagagttc 19681 aaaaattacc ccatttattg ctccacaagt gcgaaaacct caattatcgg caaccactta 19741 gagagatctc cgcttttggt caccatctat atcagcgccg gtgtgcatga gatttttgat 19801 aataccattt cagtcaacag aacagccggg aatccgattg tgatttatat caatggctct 19861 gcaggctcta tcgtctcagg aaacaccatc aataacctct ccgcggacac tgcgacagct 19921 attcaaacaa ccacatcaac caattccaaa atcatcggca accgcatttt taaagggacc 19981 atcaacaaac atagcagtga tacaatagac ggcaatatga ttgtctgaaa aaagcgcccc 20041 ctctaggggt tctttttttt cgatttatag atcatgtaga tttctctcac aagtactaaa 20101 acaaaaaata aaagcacgac ccattccgca aatgttgtca tcttaaagct ggacatattg 20161 ttataaacgg cttttgttaa actgaaccct tgaagcatgt ccatcaacac agaaatagct 20221 aataaacaaa ttaatatgac tccggtcacg cccaatatct tcatgcttca tcatcctccg 20281 cttttagtgt ctatcgttgg cggagaagtt ataccgcatc taaccctaat gcataatctc 20341 aattttaaaa ggaagaatat gagaaaacga caagggaagg tatttgtgta tgcctttatt 20401 ttctaagcga aagaacaata ccggttcaaa agacaagcag aatactgacg aaaggaacca 20461 ggaacagcag caagaaaaag aaaggccggt tctcatttct ccaagtttgg caaagaatat 20521 agcggaaacg aaaaaggaag tcggaagcag ctctgacgtc atcattcgcg agattaaaat 20581 cggggagcag gatcatgtcc acctagctgt tatctatatt gctgggctgg tcgataataa 20641 cacgatccat gagtcgttaa ttgacccatt ggtacaggat gagtctatcc agaatactca 20701 tgcgatccag caaattcttg aaaaaacgct cccgctgggc ggggtgaaag cggaaaagag 20761 ctgggacaag cttttttccg agttaatgct cggcaatgcg ctcatttttg ctgatggcca 20821 tgatgaagct ttgatttgca gcactcaagg gggagagcag cgctccatcc aagagccgag 20881 cacccaggcg tcattccgcg gtccgcgcca agggtttaca gagtctctgc aaaccaatat 20941 ttccatgatc cggcgataca ttaaaaatcc gaatttatgg gttgaaaaaa tgaaaaaagg 21001 ttctgttacg aatacggata tcgctctcat gtacattcaa ggaatatgcg ataaaaaggt 21061 gctgaaggaa gtgaagctgc gcctggaaaa aatagatatt gacagtattt tggaatctgg 21121 atatattgag cagctgattg aagatgaaac ctttacgacg tttccgacta tgtatcatac 21181 agaacgccct gatgtagtag cgggtaatct gttagaagga agattcgcga ttattgtgga 21241 cggaacaccg tttgtgctta ttgccccggc cttatttgtc cagttttttc agtctgttga 21301 ggattattat tcgcgttttg acattgcgac aagtataaga attcttcgtg ttttaatctt 21361 tttcatttcg cttgtggctc cggctgtata cgtggcagcc acgacgtttc atcaagaaat 21421 gataccgact gagctgttag tggtcattgc ggcccagcgg gaaagtgtcc cgtttccggc 21481 tgttgtggag gcgctgacga tggaggttgc ttttgagatt ctgagggaag cgggattcag 21541 gctgccccgg gttgttggct cggcagtgtc aatcgtaggc gcgctcgtaa tcggccaggc 21601 tgccgtacag gctggtatcg tctctccggc aatggtgatt atcgtggcac tcaccgcgat 21661 tgcgagcttc gcaaccccgg cgtttgcaat ggcgatttca gcccggctta ttcggtttat 21721 ttttcttatt gcctcagctg ttatgggttt ttacgggctg attttaggga tcattatgat 21781 gtttgtccac ttatgcagtc ttcgttcata cggcgttcca tatatgtcgc cgcttgcacc 21841 cttttcttca caaggcgtaa aggacacgct tttccgggtt ccgtggtggg ccgatgaaaa 21901 aaggccggaa tcggtcagca aggaagataa ggtgcggcag gggcaagatc aacgcccaga 21961 gccggccgct tcacgaggaa tggtgaacaa agatttggaa gaaggggata agaatggtac 22021 gtaaatgtct attagtcgtt ctcatgcttt tgagcgccat tgtgctgccc ggctgctggg 22081 ataagaggga gctgacggat cttgcgatta tctcggcgat tggcatcgat cggacaaacg 22141 acagcaacta cgtgctgcat cttcaaatta tcaatccagg gaatgttgcc ggcggccttc 22201 agggaggagg tgatggagac aggccgcctg tatctgtcta ttcgattgaa ggtaacaatt 22261 taacggaagc actcagaaaa gcctccataa aggtatcacg gcggctttat tttgcccata 22321 ccaatctagt cgtgatcaat gaaaagctgg caaaagaaga aggtttggat tttgtattag 22381 ataatcttga ccgggacaca gaatttaggt caacagcaac attcgtcgtt gcccataaaa 22441 caaaagcaga aaatattgtg aaaatcttga cgccaattga taaaattcca tcaaataaag 22501 tcaataaaac cttggatttc acggaggcgc aatacgggcg ggtggtcaat accaatattc 22561 aggacgtttt gaaaacactt gccgccaaca ctatggcacc ggtcatcccc ggatttatga 22621 tgattggtga cgataaaaaa ggagtcagca tggaaaacac gcaggcgact gacccgaaag 22681 ccattcttca ggcagatggt ctggcggttt ttgataaggc aggatattta aagtattggc 22741 tggaagatga tgaaagcgtg ggggcagtct ggcttatgaa taagatccag catacgttga 22801 ttaatgctga ctggggcaag acgaaggatg cggtcagctt gcaggttacc catcaagata 22861 caaagctggt accgaaaatg cggaacggac gtccgtacat ccatgtgaaa gtgtcggttg 22921 aaggtattat tgatgctgtc aaataccctt tccaattgtc tgatcccaag gtgctggccg 22981 ctattgaaaa agcgctcaac aaagagcttg aaaaggaaat tagccatact gtgaaaaaga 23041 ttaagaagaa taaaatagat tttatcggtt ttggtgacac gatatataga aagtatccgg 23101 agcagtggga gaaaatgaag gacacatggg acaaagaata tttgcccgaa ctgcccatcg 23161 atgtgaaggc cgagacgtat atcagaagga cgggattgcg aaacgatccg atcaaacacc 23221 agtttaaaga tgattaggtc tgaagaaagg ggaagtgaca gatggaaaaa gccagaataa 23281 gcataaggca gctgtttgtc atgattatca tttttgaact gggcagctcc ttattgatta 23341 caccgggatc aatggcgggc agggatgctt ggatagcagt tttattaggc tgtgcgatcg 23401 gactgtttct tttctgtttg tatcaaggca tttatcaatg ttatccgaat tcttctccga 23461 aagaatatat ggatgatatg ctgggaacca agctgagctg gctgttttca tttctctata 23521 tattgtactt tgcctataat gccgcaaggg tgctgcgtga ctttggagaa atgctgctga 23581 cgtttgctta tcatgataca cctatcatta ttgtaaatgc tttattaatg gtagtaagca 23641 tatatgccgt aagaaaagga attgaagtac tcgcacgcgc tgccgaactt cttttcgggg 23701 tcatgtattt actgggcgcg atcgggctcg tgctgattat tgtctcaggc actatagacc 23761 cgcacaattt aaagccggtt ttggcaaacg gtatttctcc tatccttcac tctgttttca 23821 cgcagaccat gtacgtccca tttggtgaag tcgttttatt tgtgatgatt ttccctatcc 23881 tgaataacag aaaagatgta aaaaaaatgg ggatgattgc catggctatt agcggattgg 23941 ttgtggcgct caccgtggcg attaatatca gcgtgcttga tgttgatctt acactcagat 24001 cccagttccc gcttttaagt acgatccaga caatcaaggt cgaagaattt ttagaccggc 24061 tcgatgtctt ttttatgctg gcgctgatca tcggcggctt ctttaaggtt agcctctact 24121 tatatgccac tgtggttggg acatctacgc tctttaagga aaagaatctc tctcaattgg 24181 cttatccgat gggattgggc atcttaatcc tttctttaac gatcgcaact aacttttcag 24241 agcacttgaa cgaaggcttg aacgtggtgc cgctgtatat tcatttgcct tttcaattat 24301 tgtttccgct ctttctgttt attgtggctg tttggaaaaa gaaacgaaga gagaagtcaa 24361 aagggacagg aataaaggaa tgataaaaag agcgggggga tgcagccgcc gctcttttta 24421 tgttcacttc tatataaaag ggggatatag ggtgcgcccc tgtctgcact ggcagaggcg 24481 cgttttgtta taccactgcg acgttttcct tcacagtaaa gcttcctctt gaaagtctga 24541 tattgatgtc tgacactttt gcaatttgtt catcgtgcgt caccataatg acgcatttat 24601 tttccttgtg cgccagatct tgaaagaggc gtacaatttc ttttgatgtg tcctcatcaa 24661 ggtttccggt cggttcatcg gctacgataa gatccgtgtc acagcagaaa gcccttgtaa 24721 ttgatacccg ctgctgctgt ccgccgctta gtgtgagcac tttttgccgg gcttgttttt 24781 cgttgatgcc aaccttttgc agcatgtcaa gcgcatatga ttctttgttc ttttctttag 24841 aacctgtgat ttccatagcg gttgtgacgt tctgcaaagc cgtcatatac gggagcagat 24901 tgtacgcctg aaagacgatt gatacatatt gatttctgaa attggttaag ccgattttag 24961 acaccgcttt tccgtcgtaa aggatgtttc cttcttttgg tgcgtcaagt ccgcctgcca 25021 gagacaggaa agtggttttc cccgtccctg atgtgccgac gattgtgtag aatttgcctt 25081 tttgaaagct gatgttaata tcctgaaaca atgactggct tttgtcttta taccagtatc 25141 cgacttgttg aaattctaat aagctcatag gttccgcctc tttctattcc tgttttgtca 25201 atatcgtttt cggatgaagc cgcagtagtg aaattgacgg cagcaatgtt gcaatgattg 25261 cgattaggat gccgatcccg cccagaataa gcatgtcgtt catagaaacc gcgacgttca 25321 gtgaatcgat aa //