LOCUS       c00083_gnlPro..        12375 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJMLLOPC_83.
ACCESSION   c00083_gnlPro..
VERSION     c00083_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 20:30:08
            Original ID  :: gnl|Prokka|CJMLLOPC_83
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12375
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12375
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2955:6146]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2956..6146
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12375
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12375
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..91)
                     /locus_tag="ctg83_1"
                     /transl_table=11
                     /translation="MGTRVSYPVEVKQKAVEMRLAGVPMKEIMQ"
     CDS             complement(226..1050)
                     /locus_tag="ctg83_2"
                     /transl_table=11
                     /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLES
                     RTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDLDD
                     GKLLVAVDTDADVIAPVDNGNALSSGFSGTNELDYTTKEEKTMPLREEQLKVDKEDVQT
                     GEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEEKLEV
                     TKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDDPLNNK"
     CDS             complement(1234..1464)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_3"
                     /sec_met_domain="Acetyltransf_1 (E-value: 6.7e-10,
                     bitscore: 29.1, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSASHLRKGVAKQVLQHIIEEAEKRGYERLSLETGSMASFEPA
                     RKLYESFGFQYCEPFADYDEDPNSVFMKKEL"
     CDS             2956..4614
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9e-55, bitscore:
                     174.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIESLKKEKVEMIFGYPGGAVLPIYDKLYNSGLVHILPRHEQGA
                     IHAAEGYARVSGKPGVVIATSGPGATNLVTGLADAMIDSLPLVVFTGQVATSVIGSDAF
                     QEADILGITMPVTKHSYQVRQPEDLPRIIKEAFHIATTGRPGPVLIDIPKDVATIEGEF
                     SYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAKKPVILAGAGVLHGKASEELKNYAEQQ
                     QIPVAHTLLGLGGFPADHPLFLGMAGMHGTYTANMALHECDLLISIGARFDDRVTGNLK
                     HFARNAKIAHIDIDPAEIGKIMKTQIPVVGDSKIVLQELIKQDGKQSDSSEWKKQLAEW
                     KEEYPLWYVDNEEEGFKPQKLIEYIHQFTKGEAIVATDVGQHQMWSAQFYPFQKADKWV
                     TSGGLGTMGFGLPAAIGAQLAEKDATVVAVVGDGGFQMTLQELDVIRELNLPVKVVILN
                     NACLGMVRQWQEIFYEERYSESKFASQPDFVKLSEAYGIKGIRISSEAEAKVKLEEALT
                     SREPVVIDVRVASEEKVFPMVAPGKGLHEMVGVKP"
     CDS             4611..5009
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_5"
                     /sec_met_domain="ALS_ss_C (E-value: 2.2e-16, bitscore:
                     49.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVSR
                     ITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEING
                     IIEPFRASVVDVSRDSIVVQVTGESXXH"
     CDS             5118..6146
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_6"
                     /sec_met_domain="IlvN (E-value: 1.1e-78, bitscore: 252.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 4e-69, bitscore: 221.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVIV
                     GVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKSLV
                     FAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEARDK
                     ALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGYQPEL
                     AYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKEVLKDI
                     QNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKEAVVSVA
                     QN"
     CDS             6133..7653
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_7"
                     /sec_met_domain="HMGL-like (E-value: 1.2e-100, bitscore:
                     326.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAG
                     FPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAYPRIHVFIATSDI
                     HLKHKLKMTREQVIERAVEMVTYAKERFPVVQWSAEDACRTELPFLAEIVEKVIDAGAS
                     VINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGAD
                     QIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVP
                     RNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRL
                     TALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQVHY
                     GTSXNAELIQEAATGAGSVEAIYNTLERCIDKDVELLDYRIQSNRKGEDAFAQVYVRVL
                     VNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMSGLKNHTAVGS"
     CDS             7674..7898
                     /locus_tag="ctg83_8"
                     /transl_table=11
                     /translation="LKKRIALLPGDGIGPEVLESATDVLKSVAERFNHXXLMNIITPSR
                     RKPLLLVKMQTRYCLVLSADRNGIKILRN"
     CDS             7847..8737
                     /locus_tag="ctg83_9"
                     /transl_table=11
                     /translation="LLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLFANLRPVKVFESL
                     SDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVDTLFYKRTEIERVI
                     REGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAKEFPDVKLEHMLVDNAAMQLIY
                     APNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVHGSAPDIAGKG
                     VANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTKDLARGEEFSSTQAITE
                     EVKAAIMSENTISNV"
     CDS             8787..10205
                     /locus_tag="ctg83_10"
                     /transl_table=11
                     /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEGL
                     RQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHSVD
                     QGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQQRP
                     KTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMTVCNM
                     SIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKSIVLDG
                     NKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKIEDIKVE
                     HVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLDQIFLEAG
                     FEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMAAMAAIHGH
                     FVDVRKFYQEKTVV"
     CDS             10218..10712
                     /locus_tag="ctg83_11"
                     /transl_table=11
                     /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFFD
                     WRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTDMMKF
                     H"
     CDS             11142..11870
                     /locus_tag="ctg83_12"
                     /transl_table=11
                     /translation="MTILIQLKKYEEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMT
                     DPDREDEAWAEEYEDTIDTEKVLASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHP
                     IIKTMIVMLLAEYEYSKPVHISKFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNEN
                     PTLYAAVEELWRRHLYVLYPFQPKLLSADLWAAALHKVGYEMHGIEIEREELHMMYEFT
                     DRELDEACTMLKDIEEISYL"
     CDS             12098..12373
                     /locus_tag="ctg83_13"
                     /transl_table=11
                     /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGFR
                     KGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPE"
ORIGIN
        1 cctgcatgat ctctttcata ggtacgcctg ccaatctcat ttctacagcc ttctgtttca
       61 cttcaaccgg ataactcact cttgtcccca tagaaaaaac acctccaagt ctaatttcgg
      121 ataacaatca tccgtattca aacttgaagg tgtttttatt tgtctcatct tatggggtca
      181 gtccccattt aggatttgag gttttttgtt gtcggtctat gatttttatt tattatttaa
      241 cggatcatca tcatccaagc cgtcaacttt tccttcttta ttcagacgag gttcttcttt
      301 tttcacagtt tcagaaatat gttcattttc ttcaacagtg cgtttgccga caaccacttc
      361 atcagtgaca accggttttt tagtcacttc aagcttttcc tcaacgattg gaactctgat
      421 ctcttccgaa tcgttgacgg gagcagcgtc cgttttattt tcatccactg gacggcgttc
      481 gacataaatt tcatcatgtc tcacaggaat gtccatatct cttttttctg ttttcacttc
      541 ttttcctatt tctacttcgc cggtttgaac gtcttcctta tcgaccttca gctgttcttc
      601 tcggagcggc atcgtttttt cttcttttgt tgtatagtcc aattcatttg tgcctgaaaa
      661 gccgcttgaa agggcattgc cgttatcaac aggagcaatt acatctgcat ctgtatcgac
      721 ggctaccaaa agttttccgt catccaaatc ttcttgatac ttgtctattt catcagtttt
      781 aatatccaag tcggataatg ctttgctgtg tgtagcagta tcatccattg tgaaataatc
      841 tttcagttta tcgaaaaaag attcagattc gtcctgatgt gcatcgatgg cttgattgac
      901 ttctgttcct gtacgtgact ccaaataatc tgtatctcgc cggcttgtca caacagaaat
      961 gtcatcagaa tcatagcctt ttgtgagtaa gccttcaatc gctgcgatgg tttcctgcgg
     1021 agtttcatat acaccaacta tgcttttcat atcaatctcc tcctttatga atttgcatga
     1081 tatcgttcat gtcgtttgta attcccgctg ttctttgaat taaacaaaat tgaaaacatt
     1141 ggcgtgtatc ataaaggtga aaaatgtgtg aaaataaaaa aagatagata agacagacct
     1201 tcccctgcac ttatctatcc ttataaaatc gtctcacaat tccttcttca taaacacact
     1261 gtttggatct tcatcgtagt ctgcaaacgg ttcacaatac tggaaaccga agctttcata
     1321 caattttctt gccggctcaa atgaagccat tgaacccgtt tctaagctta gtcgctcata
     1381 gcctcgcttc tcggcttctt caatgatatg ctggagaact tgtttggcaa cgccttttct
     1441 taaatgtgat gcagatgttc gcattgattt gacttctccg tgccagctgt ccagttcttt
     1501 tagcgctccg caaccggcta gttcatcacc ctcccannnn nnnnnnnnnn ntggatgctt
     1561 tccggcgggg acataagcgt catgctagta aatgctcatt caccagtgaa accacctgat
     1621 gtccagttaa atcatctatt tttatatgca ttttattcct cctcaaacat tcatcttaat
     1681 catattccat cctgtttcca actataaaga cagaaaatct gacagtattg aagcactttt
     1741 ggaatgtatg agttgcaaaa gatgcttgaa agcaacaann nnnnatatct aaagcctcca
     1801 tgcacaccgg ctgttccgct aaaaccgccg acatgtgtcg ccggaatact gaacccgccg
     1861 ctatggccgc tgaagccagt gcctgaaaat tgctgcccga aaaaatctga agtgtatgga
     1921 taagaggagt acatagcaga gggagtggtt aacgggctat atgcctggct gaacggctgt
     1981 ccgtatccgt agcctccaaa tggctgatgg ctttgctggt aaaagggagg gacagcagga
     2041 taatactgct gcggaaagct cgggaagctt ggaaagcctg cagggaatcc ttgcatgtct
     2101 gctaatgatt tattcatcgt atcacctttt ctttgcaaga taccattaat gtatgccggg
     2161 gaataatagt ggtgcctatc cgaacttgaa atggattgca agttgatctg tcagactcaa
     2221 tccatatacg aaccatagcg tgttataaaa tcttacatgt ttatataaaa ttaaataatt
     2281 ctggtgtatt cttgatagat taataaaaaa attataaaaa cttttaacat ttgcaattcc
     2341 ttttgtacca ataatgaaag cgtatacaat atagattgat taatcaaaat tgtctaataa
     2401 ttttaaaaaa tgctgttgac actgcgtcca aagcggcgta atatgagttc aacaaaagat
     2461 aaacgcaagc ttcacaagcg aaaatcatcg cagtatgatt ctaaaaaaat gaaaaacaaa
     2521 cgaccttctt gaacagctgg aaagccgttc tgaagggtga atatgaaaag cgcagatgag
     2581 gataagtagc cttgataaag ctttccacag agaaccgggt tagctgagaa ccggtgaagc
     2641 tttacaaggt gaactcgcct cagagtgcca gtctgaaatg acagtaggac ttggccgggt
     2701 gaacttgatt cactcgttac taaagcggat agaaatatcc atgagacggc cgactaaggc
     2761 cgtaaacaag ggtggtaccg cggaaagaaa agccttttcg ccccttttag ctatcgcagt
     2821 tactgcgcgg ctgattgtgg gtggaagggc tttttttatt nnnnnnnnnn nnnnnnnnnn
     2881 nnnnnnaaaa tgaggactaa tgtacaggtg gattcagcat ctgccaaatg tacacagacg
     2941 atgagcggag cattaatgct gattgaatca ttaaaaaaag agaaagtaga aatgattttc
     3001 ggttatccgg gcggggctgt gcttccgatt tacgataagc tatacaattc agggttggta
     3061 catatccttc cccgtcacga acaaggagca attcatgcag cggagggata cgcaagggtc
     3121 tccggaaaac cgggtgtcgt cattgccacg tcagggccgg gagcgacaaa ccttgttaca
     3181 ggccttgctg atgccatgat tgattcattg ccgttagttg tctttacagg gcaggtagca
     3241 acctctgtaa tcgggagcga tgcatttcag gaagcagaca ttttagggat tacgatgcca
     3301 gtaacaaaac acagctacca ggttcgccag ccggaagatc tgccgcgcat cattaaagaa
     3361 gcgttccata ttgcaacaac tggaagaccc ggacctgtat tgattgatat tccgaaagat
     3421 gtagcaacaa ttgaaggaga attcagctac gatcatgaga tgaatctccc gggataccag
     3481 ccgacaacag agccgaatta tttgcagatc cgcaagcttg tggaagccgt gagcagtgcg
     3541 aaaaaaccgg tgatcctggc gggtgcgggc gtattgcacg gaaaagcgtc agaagaatta
     3601 aaaaattatg ctgaacagca gcaaatccct gtggcacaca cccttttggg gctcggaggc
     3661 ttcccggctg accatccgct tttcctaggg atggcgggaa tgcacggtac ttatacagcc
     3721 aatatggctc ttcatgaatg tgatctatta atcagtatcg gcgcccgttt tgatgaccgt
     3781 gtcacaggaa acctgaaaca ctttgccaga aacgcaaaga tagcccacat cgatattgat
     3841 ccagctgaaa tcggaaaaat catgaaaaca cagattcctg tagtcggaga cagcaaaatt
     3901 gtcctgcagg agctgatcaa acaagacggc aaacaaagcg attcaagcga atggaaaaaa
     3961 cagctcgccg aatggaaaga agagtatccg ctctggtatg tagataatga agaagaaggt
     4021 tttaaacctc agaaattgat tgaatatatt catcaattta caaaaggaga ggccattgtc
     4081 gcaacagatg taggccagca tcaaatgtgg tcagcgcaat tttatccgtt ccaaaaagca
     4141 gataaatggg tcacgtcagg cggacttgga acgatgggat tcggtcttcc ggcggcgatc
     4201 ggcgcacagc tggccgaaaa agatgctact gttgtcgcgg ttgtcggaga cggcggattc
     4261 caaatgacgc ttcaagaact cgatgttatt cgcgaattaa atcttccggt caaggtagtg
     4321 attttaaata acgcttgtct cggaatggtc agacagtggc aggaaatttt ctatgaagaa
     4381 cgttattcag aatctaaatt cgcttctcag cctgacttcg tcaaattgtc cgaagcatac
     4441 ggcattaaag gcatcagaat ttcatcagaa gcggaagcaa aggtaaagct ggaagaggca
     4501 ttaacatcaa gagaacctgt tgtcattgac gtgcgggttg ccagcgaaga aaaagtattc
     4561 ccgatggtgg ctccggggaa agggctgcat gaaatggtgg gggtgaaacc ttgaaaagaa
     4621 ttatcacatt gactgtggtg aaccgctccg gggtgttaaa ccggatcacc ggtctattca
     4681 caaaaaggca ttacaacatt gaaagcatta cagttggaca cacagaaaca gccggcgttt
     4741 ccagaatcac cttcgtcgtt catgttgaag gagaaaatga tgttgaacag ttaacgaaac
     4801 agctcaacaa acagattgat gtactgaaag tcacagacat cacaaatcaa tcgattgtcc
     4861 agagggagct ggccttaatc aaggttgtct ccgcaccttc aacgagaaca gagattaatg
     4921 gaatcataga accgtttaga gcctctgtcg ttgatgtcag cagagacagc atcgttgttc
     4981 aggtgacagg cgaatctnnn nggcattaaa gaaatcgcga gaacaggtac aacggctttt
     5041 gcgaggggta cccagcaaaa ggcgtcatcc aataaaacaa tatctattgt ataaaacata
     5101 acaagggaga gattgaaatg gtaaaagtat attataacgg tgatatcaaa gagaacgtat
     5161 tggcaggcaa aacagtagcg gttatcggat acggttcgca aggccacgca catgccctga
     5221 accttaaaga aagcggagta gacgtgatcg tcggtgttag acaaggaaaa tctttcacgc
     5281 aagcccaaga agacggacat aaagtttttt cagtaaaaga agcggcagcc caagctgaaa
     5341 tcatcatggt tctgcttcct gatgaacagc agcaaaaagt atacgaagct gaaatcaaag
     5401 atgaattgac agcaggaaaa tcattagtat ttgctcacgg atttaacgtg catttccatc
     5461 aaattgttcc tccggcggat gttgatgtat tcttggtagc gcctaaaggt ccgggacact
     5521 tggtcagaag aacatatgag caaggagccg gcgtacctgc attgttcgca atctatcaag
     5581 atgtgactgg agaagcaaga gacaaagctc tcgcatatgc aaaaggaatc ggtggcgcaa
     5641 gagcgggagt attagaaacg acatttaaag aagaaacaga aacagatttg ttcggtgagc
     5701 aagcggttct ttgcggcgga ttaagcgcgc ttgtcaaagc aggatttgaa acattaactg
     5761 aagcaggtta tcagcctgaa cttgcatact tcgagtgtct gcatgagctg aaattaatcg
     5821 tagaccttat gtacgaagaa ggacttgcag gaatgagata ttcaatttct gacacagcac
     5881 agtggggaga tttcgtatca ggccctcgcg ttgtggatgc taaagtaaaa gaatcgatga
     5941 aagaagtatt aaaagatatc caaaacggta cattcgcaaa agaatggatc gtcgaaaacc
     6001 aagtaaaccg tcctcgtttc aacgctatca atgcgagcga gaacgaacat caaatcgaag
     6061 tagtgggaag aaagcttcgt gaaatgatgc cgtttgtgaa acaaggcaag aagaaggaag
     6121 cggtggtctc cgttgcgcaa aattaatttt ttcgatacga cgcttcgtga tggtgaacag
     6181 tcccctggag tgaacttgaa tacacaggag aaacttgcca tagctaagca gctcgaaaga
     6241 ctcggggcag atatcattga agcgggattt cccgcttcgt cccgaggtga ctttttagct
     6301 gttcaggaaa tcgctagaac cattaaaaat tgttcagtga ctggtctggc ccgttgtgta
     6361 aaaggtgata ttgatgctgc ttgggaagcg ttaaaggatg gtgcttaccc gagaattcat
     6421 gtttttatcg ccacatcgga cattcatttg aaacacaagc tgaaaatgac acgtgagcaa
     6481 gtcattgaaa gagcagttga aatggtgaca tacgcaaaag aacgttttcc ggttgtgcaa
     6541 tggtcagctg aagatgcctg ccgcactgag ctgccgtttc tggcagaaat cgtcgagaaa
     6601 gtgattgacg caggcgccag tgttatcaat cttccagaca ctgtcggcta cctggctcca
     6661 gcggaatacg gaaatatctt taaatatatg aaggaaaacg ttccgaacat tcacaaagca
     6721 aagctttcag cccactgtca tgatgattta ggaatggcag ttgcaaactc tcttgctgcg
     6781 attgaaaatg gcgctgatca aatcgaatgc gctgtgaacg ggatcggtga aagagccgga
     6841 aacgcggcat tagaggaaat tgccgtagcc ctccatacca gaaaagattt ctaccaagtc
     6901 gaaacaggca ttacactgaa cgagattaag agaacaagtg atttagtaag caaactgaca
     6961 ggcatggctg tcccacgcaa caaagcggtt gttggagata atgcatttgc tcatgaatca
     7021 ggcatccatc aggacggctt tttaaaggaa aaatcgactt atgaaattat ttcaccggag
     7081 cttgtcggcg taaccgcaga tgcgcttgtc ctaggtaaac attccggacg ccacgcattt
     7141 aaagaccggc tgactgcttt aggattccaa tttgacagtg aagagattaa taaattcttt
     7201 acgatgttca aagagttgac tgagaagaaa aaagaaatca ctgatgagga tcttgtttct
     7261 cttattttag aagaaaaagt aacagatcgc aagattgggt atgaatttct ttctctgcaa
     7321 gtacattacg gaacaagtnn aaatgcagag cttattcagg aagctgcaac tggagctgga
     7381 agtgtggaag caatctacaa tacgcttgag cgctgcatcg ataaggacgt ggagctttta
     7441 gactaccgca ttcagtctaa cagaaaaggc gaagatgcat ttgcccaggt gtatgtaaga
     7501 gttttggtga acggaaaaga atcagcaggt cggggcatag cgcaagacgt attagaagca
     7561 tcagcgaaag cctatttgaa cgcagtcaac cgtcaattgg ttttccagtc gaatatgagc
     7621 ggattgaaaa accacacagc tgtcggatca taaaagaaag gagaacggtt aacttgaaga
     7681 aacgtattgc tctattgccc ggagacggga tcggccctga agtattagaa tcagcgacag
     7741 acgtactgaa aagtgttgcc gaacgcttta accatgannt attgatgaac atcataaccc
     7801 cctcccggag gaaaccgttg ctgcttgtaa aaatgcagac gcgatattgc ttggtgctgt
     7861 cggcggaccg aaatgggatc aaaatccttc ggaactgaga ccggaaaaag ggctgctcag
     7921 catcagaaaa cagcttgatt tgtttgcgaa tttacggcct gtgaaggtat ttgaaagcct
     7981 ttctgatgct tcgcctttga aaaaagaata tatagataat gttgatttcg ttatcgttcg
     8041 tgaactcaca ggcggcttgt atttcggcca gccgagcaaa cgctatgtaa acactgaagg
     8101 tgagcaggaa gcagtagata cactgtttta taagcgaacg gaaattgaac gagtgatcag
     8161 agagggcttc aaaatggcgg cagccagaaa aggcaaagtg acctctgtag ataaagcgaa
     8221 tgttcttgaa tcaagccggc tgtggcgtga agtggctgag gacgttgcga aagaatttcc
     8281 tgatgtgaag cttgagcaca tgcttgtgga taacgcggcc atgcagctaa tctatgcacc
     8341 gaatcaattt gatgtcgttg tgactgaaaa tatgttcggt gatattttaa gcgatgaagc
     8401 gtccatgctt acaggctcgc tcggaatgct cccgtcagcc agcctatcaa gctctggtct
     8461 tcatctgttt gaacctgttc atggctccgc gcctgatatt gccggtaaag gggtggcaaa
     8521 tccgttcgca gccatattgt cagcggcaat gcttttgaga acatctttcg ggcttgaaga
     8581 ggaagcgaaa gctgtagaag atgcggtaaa caaagtcttg gcttctggga aaagaacaaa
     8641 agatttggca cggggtgaag agttcagcag cactcaggcc attacagagg aagttaaggc
     8701 agcaatcatg agtgaaaata caatttctaa tgtgtgacag cttacgttaa gcggtcttag
     8761 ctctaggtag agggaggaaa taaaagatga tgcctcgaac aatcatcgaa aagatttggg
     8821 atcagcatat tgtaaaacat ggtgagggaa agccggatct tctctatatt gatttgcacc
     8881 tcattcatga ggtgacgtct cctcaggcat ttgaaggctt gagacaaaag ggaagaaagg
     8941 tcagaagacc ccaaaacaca tttgcgacaa tggaccacaa catcccgact gtcaatcgtt
     9001 ttgagataaa ggatgaagtt gcgaaacgcc aggtaacggc gcttgaaaga aactgtgagg
     9061 aatttggcgt gcgccttgcc gatcttcaca gtgtggatca agggattgtc catgtcgtcg
     9121 gacctgaact gggcttaacg cttccaggga aaacgattgt gtgcggggac agtcatacat
     9181 caacacatgg tgctttcggc gctcttgcat ttgggatcgg gacgagtgaa gttgaacatg
     9241 tcctttccac acagacactt tggcagcagc gtccaaaaac acttgaagtg cgcgtagatg
     9301 gaacgcttca aaaaggggta acggcaaagg atgtcatcct tgctgtcatc ggcaaatacg
     9361 gtgtgaaatt cggcacaggc tacgtcattg aatacactgg ggaagtattc agaaatatga
     9421 cgatggatga acgaatgact gtttgtaaca tgtcaattga agcaggagca agagcaggtt
     9481 tgattgcacc tgacgaggtg acgtttgaat attgcaaaaa tcgcaagtac acgccaaaag
     9541 gcgaagaatt tgacaaggcc gtagaggaat ggaaggcgct gcgcacagac ccgggcgctg
     9601 tttacgataa atctattgtc cttgacggca acaaaatttc ccctatggtg acatggggca
     9661 ttaacccggg aatggttctt cctgtcgatt ctgaagttcc tgcgccggaa agcttttctg
     9721 cagaagatga caaaaaagaa gcgattcgcg cttatgaata tatgggactg actcctcatc
     9781 agaaaattga agacattaaa gtggagcacg tatttatcgg ttcctgcaca aattcccgca
     9841 tgactgacct tcgacaggct gctgacatga tcaaagggaa gaaggtagct gacagcgtaa
     9901 gggccatcgt cgtgcccgga tcccaaagcg tgaagcttca ggctgaaaaa gaagggcttg
     9961 accagatttt cttggaagct ggatttgaat ggagagagtc aggctgcagc atgtgtttga
    10021 gtatgaataa tgatgttgtt cctgagggag agcgctgtgc atcaacctct aaccgcaact
    10081 tcgagggcag acaaggaaaa ggtgcaagaa cacatctcgt cagcccggcg atggctgcga
    10141 tggctgccat tcacggacac ttcgttgatg tcagaaagtt ttatcaggaa aaaacagttg
    10201 tgtaaggagt gcgcgagatg gaacctttga aatcacatac ggggaaagca gccgtattaa
    10261 atcggatcaa tgtggataca gaccagatta ttcctaagca atttttgaag aggattgaaa
    10321 gaacaggcta cgggcgtttt gcattctttg actggagata tgatgcgaat ggtgaaccga
    10381 accctgaatt tgaattaaac cagcctgttt atcaaggagc ttccatttta atagcaggag
    10441 aaaacttcgg ctgcgggtca tcgcgtgaac acgctccgtg ggcacttgat gattatnnnn
    10501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    10561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    10621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    10681 nnnnnnnaac ggatatgatg aaatttcatt aacgctgctg ctggaagatg aaatcaagca
    10741 atttgaatca caaagaagct cttggcttca agcctgaaaa agcggccggt atttgtccgg
    10801 cggctttttt ttgcctgatg aaacctttca tttcttgttt ttgttcacag gtgttgatac
    10861 acttgaacaa aataaatgcc tgaaaggaat ataggtatga cgcatgacaa gaagaacgca
    10921 aaaattattc cttttcctca tctgaaagac cgccttgtgg aaaaggggat gtcatcacta
    10981 aaggaaaaaa agtatcaaga agcgcttgaa ctgttttcag aagcgatgaa atatnnnnnn
    11041 nnnnnnnnnn nnnnnnnnnc gagctggaag aggcaaaaag cgtgtgcgag aagatgctca
    11101 aagaaggtta tggccattat tttacggttt tgcaggtgta catgaccatc ttaattcagc
    11161 tcaaaaaata cgaggaagtc aaaagcacca ttgaagccgt tttggaagaa aatcagctgc
    11221 cggcagaaag cgccgagcaa ttttataagc tgctggattt cagccggaaa atgaccgatc
    11281 cggatcgtga ggacgaggct tgggccgaag aatatgagga tacaattgac accgagaaag
    11341 tgctggcaag ccctgaggag caaatgaatc tcattcattc cttaaaagac cgtaacgtag
    11401 caaagtatac aggattgctc aaaacaatcc tccaagaccc ctcagcccat ccgattatca
    11461 aaacgatgat tgtcatgctg ttggctgagt atgagtacag taaacctgta cacattagca
    11521 aatttggcga gtcgttgaca attgaaccgt ctgagattgt tccgcctgat gccgccccga
    11581 ttttgcaccg tgttctcagg gtgctggatg agacacttgg aaatgaaaat ccaaccttat
    11641 atgcggcagt agaagaattg tggagaagac atttgtacgt tttatatccg ttccagccga
    11701 aattgctgtc ggctgacctt tgggcggctg ccctgcataa agtcggttac gagatgcacg
    11761 gaattgaaat tgaaagagaa gaacttcata tgatgtatga atttaccgac agagaactcg
    11821 atgaagcttg cacaatgtta aaagatattg aagaaatttc ttatttgtaa atcgcgccat
    11881 atagttgaaa gcgctatgtg ttatgttata atatagtggt tgtatttgtg tataacgggt
    11941 tataagaaat acggttggac aggctttgca gttcattatt aacatctata cataatgatt
    12001 ctgatctttg gcagctttgt ttttgttgga cgaagccgaa tgattgcttt agaatggaag
    12061 accgacacaa cctgaataga tttttggagg gaaacacatg tctgtaaaat gggaaaaaca
    12121 agaaggcaac gaaggcgttt taacggttga agttgatgct gaaacgttta aaacagcact
    12181 tgatgatgca tttaaaaaag tagtaaaaca agtttcaatt cctggattcc gtaaaggtaa
    12241 aattcctcgc ggattattcg aacagcgctt tggcgtagaa gctctttacc aagatgcttt
    12301 ggatattctt cttcctgtag aataccctaa agcggttgaa gaagctggaa tcgagcctgt
    12361 agaccgtcct gaaat
//
