LOCUS       gnlProkkaGABLIMEM_12   14096 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GABLIMEM_12.
ACCESSION   gnlProkkaGABLIMEM_12
VERSION     gnlProkkaGABLIMEM_12
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 19:19:49
            Original ID  :: gnl|Prokka|GABLIMEM_12
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14096
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14096
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1081:4096]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1082..4096
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..14096
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14096
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             63..251
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_1"
                     /transl_table=11
                     /translation="MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGGAQALGFTDG
                     NCLASITADCTPWIWGC"
     CDS_motif       63..170
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGG"
                     /locus_tag="ctg12_1_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       171..251
                     /prepeptide="core"
                     /locus_tag="ctg12_1_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2643.0"
                     /monoisotopic_mass="2641.2"
                     /core_sequence="AQALGFTDGNCLASITADCTPWIWGC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGG"
                     /leader_location="[62:170](+)"
                     /alternative_weights="2661.0"
     CDS             323..511
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_2"
                     /transl_table=11
                     /translation="MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGGAQALGFTDG
                     NCLASITADCTPWIWGC"
     CDS_motif       323..430
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGG"
                     /locus_tag="ctg12_2_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       431..511
                     /prepeptide="core"
                     /locus_tag="ctg12_2_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2643.0"
                     /monoisotopic_mass="2641.2"
                     /core_sequence="AQALGFTDGNCLASITADCTPWIWGC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGG"
                     /leader_location="[322:430](+)"
                     /alternative_weights="2661.0"
     CDS             complement(530..595)
                     /gene="allorf_000530_000595"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_000530_000595"
                     /protein_id="allorf_000530_000595"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSNLNGSPLRYYCELTCSRIK"
     CDS_motif       complement(575..595)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MSNLNGS"
                     /locus_tag="allorf_000530_000595_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(530..574)
                     /prepeptide="core"
                     /locus_tag="allorf_000530_000595_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.70"
                     /molecular_weight="1709.0"
                     /monoisotopic_mass="1707.9"
                     /core_sequence="PLRYYCELTCSRIK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNLNGS"
                     /leader_location="[574:595](-)"
     CDS             1082..4096
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     974; E-value: 1.5e-294)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="DUF4135 (E-value: 3e-109, bitscore: 360.1,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.9e-64, bitscore:
                     210.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKSLKEVSNLEVGTIINLQKNDLTWKYQWEELLKGSVEDYFSTT
                     PPVFSGFVERFLLLAIDLLEKQGTIRGLDSHILHTSNSLFKSLLPSLFQRIIDFSYKTL
                     ILELNVLSDQGLLQGETSEKRYQYFENLLHDKEYLRQLANEYPELIRSLLRITEKWAVH
                     VSEVLNRFTADYSKIVSHMPEVKQFGKLVRLHIGAGDTHDGRSVTMLEFTTGCKLVYKP
                     RSLKVDKGYYRILSWMRQFGVPYMKIIENIDCGSYGWTEFVEFSECKSLEEISEFYKNM
                     GVNLAMMYMFNATDFHYENIIAHGSSPVVIDLESLFHRHISTKKFEHDANGHAYEILYY
                     SVMSSGMLPQYIYNSETYSGFDISGIFGSGGKKVPNAVSLVDRGTDRMRLERSMGESGK
                     THNLPHYNNEVVDSYRYINDIEQGFAQAYRIMMENKHRLKEMIREFDDVRVRVIVRNTR
                     AYGELMRTLYHPDLLRDELDRKVVLHRLWLQCLADPKHLKFVPYEMRDIEDGDIPIFYT
                     CPSERDAWASNGERIPQLFEQSGIDIVINKIDKMGEKDLKEQLQLLNMSVLASKPDLYS
                     YRIPEIQLKDSNDVLGSNWKAEYVRLATSIGESLVQSAIIPSNNAADDITWIGLVASGD
                     DERKLRLIPVGNDLYNGNSGIALFLGYLSERTANNQYKNMARKALQPLLEIMRDKCRSN
                     AVSLNIGAFEVGSIGGGVFVTYQLSRLWNDEELLQTVKEYLPYYCELVDKDTAFDYIGG
                     AAGAIDVLLHIYHGTGWTEALQGAEKCAEHLLQNAQTLPDGSMAWFTTPNRKLYVGYSH
                     GVSGIIASLSSLYRVTQRAEYIEFIEKGLQYERANYCAELKNWVTPNDTARVTWCHGAP
                     GILLSRLRLLENGYWDVHIDQEINIALETTLKLGFGTEPVYCHGDFGQLEILLYANSVL
                     DRNEDTINVVRAYLLRLLNDQPWNNTGVHRAFDIKGLMGGLSGIGFGLLKQAFPEEVPN
                     ILNLENDKFFSSISG"
     CDS             4137..6272
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 265.9; E-value:
                     1.3e-80)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.3e-41, bitscore:
                     134.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARRRIPYVEQMHQSECGLCCLAMISAYYQKEVSLSRLRERADVG
                     RDGTTLLQLKRIAESLGFGVKAYRIEHIDQLKQVSLPAILHWNQDHFVVLEKIDNNYAR
                     IVDPRFGRIKLSLKSFSEQFTGFLMTVDLTERLDVEKDQNVWLNSLVYVKSHKNLFVYV
                     FLITLALQVIIVGMPLFMKHVIDEIMIPKNSSLSITVFISIISFLLAYMLITFARSRVL
                     VRLHNALDYEMQTSFFSHLLKLPLPFFLLRSYGDMLFRMNSLATIRNQLSGTLITGILD
                     GFMLFVLSGYMLFISPLLAMVVFLLVSINILLVIFTKRYVAEINQQQVVATTEVQAVQT
                     EMLYGIMGVKISGTEQQVYSQWLNKFKYLLQVYRRKENLNSYITTTSNGLQFMSPLIVL
                     SIGVLLVTGKYSSMTVGELVSFQAIATLLFTTSSSLMNTINSYILTTTILKRTHDVLES
                     PIEQNEGKLQVKVRGDIRLSHVSFSYSKYSPKVINDISLHIKLGQKIAIIGQSGSGKST
                     LAHLMIGLFTPTSGEIYYDNHETSDLDMQYVRKQMGIVPQDISLLNRSIYDNIVLHQDG
                     VTMDEVVRVAKAANIHDEIMAMPMKYQTVLAEMGRNISGGQRQRIALARALLNNPTVLV
                     LDEATSALDHISEARVDEYLSSINCTRIVIAHRLSTVMNSDMIIVLENGKVCDVGNHSQ
                     LLHTSNYYQYYYKEMSS"
     CDS             6348..7298
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 179.8; E-value:
                     1.1e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_5"
                     /transl_table=11
                     /translation="MKTVLSVQHLTKEIKGKMIVQDISFDVVEGEIIGLLGANGAGKTT
                     TMKMIVGLSTISSGDVQIAGYSIKSQFSKALFNVGAVIEAPAFYPYLSGYENLRQYQRL
                     HKNASKDWLLEVASLTGIEHALKQRVGTYSMGMKQRLGIAQALLRKPKLLVLDEPMNAL
                     DPSGVRETRNYLNRIAADLGVAIVISSHQLSEIEQMARRVVIMQNGCLVTEQRIDDGLN
                     DGKFCITLHIDNVELTSEVVVNLFGDDYHALDYMQTQKLSNGLHTMTVAIDEGQVPKLI
                     RALCDAGVEVHRVLSAHTSLEDKFLKWTTARGEVG"
     CDS             7300..8040
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MLWNECLKIVNKRIFILSHIGFIVMTVLFSWAYTSNLKADDTVAQ
                     MVNALLGLSGMLVILPWAIVLSPLIWTDEYQYGTLKQLFLHTSSRSRLYVAKITAMILL
                     IITSVVNIFIVSLLVNLLMAPKNIQWGDMTDVIYSIGAIVLQCCLYASLASLIGVWTRS
                     AAIAVGGSLVLYFLQMIFGGSLLSTSWTHILFIHHDDLSVYWSMSQYKSELVGVPISLA
                     IDIGYILFFFAIGLWLFVKERGAD"
     CDS             8060..8167
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MSNIGYSYVIYGDTRDNCMEDKIMNVKLKVANNDK"
     CDS             8499..8618
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MFSFFFFYYNEKKKEEGDGNVILMVIPIFMKIKKAWEGK"
     CDS             8620..8712
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="MMFSQLAFKNISRNIHTYAAYFSSENVMLE"
     CDS             8896..9495
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MSFSQFNIDIFRAINDLGKQYSFLNSAMVFLAEYMVYILALIIIA
                     YWFTGSRKSRMMVIQAMVAFVIAEVIGKIAGKFHLNYQPFAVLPDVNKLVDHAVDNSFP
                     SDHTILLFSICFSFWLVRKKTGWLWLILAFCVAISRIWVGVHYPFDVAIGALIGCVSAL
                     FSYWLVPKFSFIKQLLTLYERVEKRVLPSKNKSKEF"
     CDS             9492..9611
                     /gene="allorf_009492_009611"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_009492_009611"
                     /protein_id="allorf_009492_009611"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSIQVSVKNTDADDLYMGCIHVAAVAEQIKEQQRMKKAS"
     CDS_motif       9492..9545
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MSIQVSVKNTDADDLYMG"
                     /locus_tag="allorf_009492_009611_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9546..9611
                     /prepeptide="core"
                     /locus_tag="allorf_009492_009611_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="2350.8"
                     /monoisotopic_mass="2349.3"
                     /core_sequence="CIHVAAVAEQIKEQQRMKKAS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSIQVSVKNTDADDLYMG"
                     /leader_location="[9491:9545](+)"
     CDS             10054..10287
                     /gene="allorf_010054_010287"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_010054_010287"
                     /protein_id="allorf_010054_010287"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRSFVKVKWCQQKVVHFMRLLVAPVIHCMSKNRSLSQDFGFVYIS
                     LNLLNAQSNAGALSVVRTAGSPNVLTNLFIKA"
     CDS_motif       10054..10107
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MRSFVKVKWCQQKVVHFM"
                     /locus_tag="allorf_010054_010287_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       10108..10287
                     /prepeptide="core"
                     /locus_tag="allorf_010054_010287_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="6169.1"
                     /monoisotopic_mass="6165.4"
                     /core_sequence="RLLVAPVIHCMSKNRSLSQDFGFVYISLNLLNAQSNAGALSVV
                     RTAGSPNVLTNLFIKA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRSFVKVKWCQQKVVHFM"
                     /leader_location="[10053:10107](+)"
                     /alternative_weights="6187.2"
                     /alternative_weights="6205.2"
                     /alternative_weights="6223.2"
                     /alternative_weights="6241.2"
                     /alternative_weights="6259.2"
                     /alternative_weights="6277.3"
                     /alternative_weights="6295.3"
                     /alternative_weights="6313.3"
     CDS             complement(10179..10328)
                     /gene="allorf_010179_010328"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_010179_010328"
                     /protein_id="allorf_010179_010328"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MDIQLRKKRDHQAAYAFMKRLVKTFGEPAVLTTDKAPALLCAFNK
                     LREI"
     CDS_motif       complement(10281..10328)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MDIQLRKKRDHQAAYA"
                     /locus_tag="allorf_010179_010328_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(10179..10280)
                     /prepeptide="core"
                     /locus_tag="allorf_010179_010328_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.50"
                     /molecular_weight="3668.4"
                     /monoisotopic_mass="3666.1"
                     /core_sequence="FMKRLVKTFGEPAVLTTDKAPALLCAFNKLREI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDIQLRKKRDHQAAYA"
                     /leader_location="[10280:10328](-)"
                     /alternative_weights="3686.4"
                     /alternative_weights="3704.4"
     CDS             10416..10550
                     /gene="allorf_010416_010550"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_010416_010550"
                     /protein_id="allorf_010416_010550"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNVFIFLLPNLIDKVSVFMNPAHDDCWVNRNTTLFQDFGYITIA"
     CDS_motif       10416..10472
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MNVFIFLLPNLIDKVSVFM"
                     /locus_tag="allorf_010416_010550_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       10473..10550
                     /prepeptide="core"
                     /locus_tag="allorf_010416_010550_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.50"
                     /molecular_weight="2858.1"
                     /monoisotopic_mass="2856.3"
                     /core_sequence="NPAHDDCWVNRNTTLFQDFGYITIA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNVFIFLLPNLIDKVSVFM"
                     /leader_location="[10415:10472](+)"
                     /alternative_weights="2876.1"
                     /alternative_weights="2894.1"
     CDS             12763..12978
                     /locus_tag="ctg12_11"
                     /transl_table=11
                     /translation="MAKSQAKKKREHRLRNGGRDVLLSRGSKPSFSTHERMTRSKKEIL
                     NKRKHKNPYDHTAVDDKDFFVPQKAA"
     CDS             13079..13723
                     /locus_tag="ctg12_12"
                     /transl_table=11
                     /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTIS
                     QKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFIMV
                     FLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLIRQL
                     FVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF"
ORIGIN
        1 agggatacct tactttattc tagagcaagt tgatttacag tagtaacaag gaggtgataa
       61 ctatgcaatg gaaaaatcaa atggaaaatc ttaatgcagc tacatataat ccggtaggta
      121 gtgtattatc tgaattgaca gatactgaga tggatacagt agctggtggt gctcaagcgc
      181 taggctttac ggatggtaat tgtctagctt ccattacggc tgattgtacg ccttggatat
      241 ggggatgtta gtgaatctta agggatacct tactttattc tagagcaagt tgatttacag
      301 tagtaacaag gaggtgataa ctatgcaatg gaaaaatcaa atggaaaatc ttaatgcagc
      361 tacatataat ccggtaggta gtgtattatc tgaattgaca gatactgaga tggatacagt
      421 agctggtggt gctcaagcgc taggctttac ggatggtaat tgtctagctt ccattacagc
      481 tgattgtacg ccttggatat ggggatgtta gtgaatctta aggaatacct tactttattc
      541 tagagcaagt taattcacaa tagtaacgga gtggtgatcc gtttaggttt gacatggatt
      601 ctatcggagg gcatcctgct aatattatcg aagcattgta aatggtgctt gctgagtata
      661 tagcttaaaa tgccctcctt tctccatgta gttgtgtcaa ttatctgctt ctaaattggg
      721 atacagccga gatacatgta attttgagtc ataactttaa ttatattttc aaactgactt
      781 aaaatcaagg ttttctctat aaattttgaa cttattttta taaaattgga acgaagtgtt
      841 ttcagtagct aactaatgga tgattaaggt taacccataa tagacaaatt ctttaataaa
      901 aatagacgaa acaatattta taagctcact aaatcgcctc tagaaataaa aagtaagtct
      961 atgacctatt tttacacgta tctcggatgt atacctaaat agaaaggttg ttttataagt
     1021 gataaatact agtgaaaagt taaaatattg gtcaaaattt ttctatgata aagaggagta
     1081 tttggaaaag agcctcaaag aggtgtccaa tctagaagtt gggaccatta taaatttgca
     1141 gaaaaatgat ttaacatgga aatatcagtg ggaagagttg ttgaaaggct cagtggaaga
     1201 ctacttttct actactccgc ccgtattttc gggattcgtt gaacgttttt tattactggc
     1261 tattgattta ttggaaaagc agggaacaat tcgtggttta gattctcata ttttacatac
     1321 aagtaattct ctttttaaaa gtctgctacc ttctttattt caaagaatca tagattttag
     1381 ttacaaaact ttaatattag aattaaatgt attgagtgat cagggacttc tacaaggaga
     1441 aacttcagaa aagagatacc agtactttga aaatttgcta catgacaaag agtatttaag
     1501 acaattggcc aatgaatacc ctgagttaat tcgttcattg cttcgtataa ctgaaaaatg
     1561 ggcagtccat gttagtgaag tgttaaatag gttcacggct gactattcga aaattgtttc
     1621 acatatgcct gaggtcaagc agtttggcaa gcttgttcgg ctacatattg gtgcaggcga
     1681 tactcacgat ggacgaagtg taacgatgtt agagtttaca acaggatgca aattggtata
     1741 taaaccccgt tcactaaagg ttgataaagg atattatcga atcctgtcgt ggatgcgaca
     1801 gtttggtgtt ccgtatatga aaataataga aaatatagat tgtggaagtt acggttggac
     1861 agagtttgtg gagttttctg agtgcaaatc ccttgaagaa attagtgaat tctataaaaa
     1921 tatgggcgta aacttagcta tgatgtacat gtttaatgct acagacttcc attatgagaa
     1981 tattattgcg catggatcta gccctgttgt aattgatcta gaatctttgt ttcatcgtca
     2041 tataagtacg aagaaatttg aacatgacgc caatggtcat gcctatgaaa ttctatatta
     2101 ttctgttatg tcttctggca tgttaccaca gtatatttat aactcagaga cgtactcagg
     2161 ttttgatatt agcggtattt ttggatccgg tggaaaaaaa gtaccgaatg cagtgagtct
     2221 cgttgacaga ggaacggatc gaatgaggtt agaaagaagt atgggggaat caggaaaaac
     2281 tcataatctt ccacattata ataacgaagt tgtagatagt tatcgatata ttaatgacat
     2341 tgaacagggt tttgctcaag catacaggat tatgatggag aataagcaca gactgaaaga
     2401 aatgattcga gagtttgatg acgttagagt tagagtgata gtgcgaaata ctagagcata
     2461 tggtgaacta atgcgtacgc tatatcatcc tgatttattg cgagacgaat tagatcgtaa
     2521 agttgttttg catcgattat ggttgcaatg cttagctgat cctaaacatt taaaatttgt
     2581 tccctacgag atgcgcgata ttgaagacgg ggatatccct atcttttaca cctgtccgtc
     2641 tgaaagagat gcttgggcat ctaatggtga acgaattccg cagttatttg agcaatcagg
     2701 tatagacatt gtaataaaca aaatcgataa aatgggcgag aaggacttaa aagaacagtt
     2761 gcaattacta aatatgtctg ttttagcatc taagcctgac ctttattcct atcgtattcc
     2821 tgaaattcaa ttaaaagatt caaacgatgt gctagggtct aattggaaag ccgagtatgt
     2881 ccgattagct acttcaattg gagaaagttt ggttcaatcg gcaattatac cttcgaataa
     2941 tgcagctgat gatataacat ggattggttt agtagccagt ggcgatgatg agagaaaact
     3001 gagactaatt ccagtaggaa atgaccttta taatgggaat agtggaattg ctttgttttt
     3061 gggttattta tctgaacgga ctgcaaataa ccaatataaa aatatggctc gaaaagcatt
     3121 gcagccgttg ttagaaatta tgagggataa gtgcagatca aatgctgtat cgttaaacat
     3181 tggagcattt gaagttggta gcatcggtgg tggcgtattt gttacttatc agttgtcacg
     3241 cttatggaat gatgaagagt tactacaaac tgttaaagaa taccttcctt attattgtga
     3301 actcgttgat aaagacactg cattcgatta tataggtggt gcagctggag ctattgatgt
     3361 acttttacat atatatcatg gaacgggttg gacagaggcg ttgcaaggtg cggagaaatg
     3421 tgcggagcat ttgcttcaga atgcacaaac attgccagat ggtagtatgg cttggtttac
     3481 gacaccgaat cgtaagctct atgtggggta ttctcacggc gtatctggaa ttattgcttc
     3541 attatcatcg ttatacaggg taactcaacg tgcagagtac attgaattta ttgaaaaggg
     3601 attacagtat gagcgtgcaa actattgtgc tgaattgaaa aattgggtta ctcctaatga
     3661 tactgcaagg gttacatggt gtcatggtgc gccgggcata ttattatctc gactacgatt
     3721 gttggaaaat ggatattggg acgtacatat tgatcaagaa attaatattg ctcttgaaac
     3781 aactcttaaa ttaggttttg ggacagaacc tgtttattgt cacggcgatt ttggacaatt
     3841 agaaatatta ctttatgcta attcagttct tgatcgtaat gaggatacta tcaatgtagt
     3901 cagagcgtat ctgctcagac ttctaaatga ccaaccatgg aataacacgg gggtccatcg
     3961 cgcttttgat attaaaggat taatgggtgg tctgtcgggt attggatttg gtctattaaa
     4021 gcaggcattt ccggaagaag ttcctaacat tttaaacttg gagaatgata aattcttctc
     4081 ttctatttct ggataaattg tgtgatcata aatcaaagta gaagggagag aatgtaatgg
     4141 ctcgtcggcg tataccgtat gtcgagcaga tgcatcagtc ggaatgtgga ctttgttgcc
     4201 ttgctatgat atcagcctac tatcaaaagg aagtttcatt atctagacta cgtgaaaggg
     4261 cggacgttgg acgggatggt acaacactat tgcaattaaa gagaattgct gagagcctag
     4321 gctttggtgt taaagcttat cgcattgaac atattgatca attaaagcag gtttctttac
     4381 cagcaattct acattggaac caagatcatt ttgtagttct tgaaaagata gataacaatt
     4441 atgctcgtat tgttgaccca cgttttggaa gaatcaagct gtcattaaag agcttcagcg
     4501 agcaatttac tggatttttg atgacagtgg atttaacaga acgactcgac gttgagaaag
     4561 atcagaatgt ttggttaaat tctttagtct atgtaaaatc acataaaaat ctgttcgtat
     4621 atgtttttct tattacactg gctttgcaag tcataatagt aggtatgccg ttattcatga
     4681 aacatgttat tgacgaaatt atgattccga aaaattcgag tttatctata acggttttta
     4741 tatctataat cagctttcta cttgcataca tgttaattac attcgcgcga agtcgtgttt
     4801 tggttcgatt gcacaatgct ttggattatg agatgcagac aagctttttc tcacatttat
     4861 tgaagttgcc tttaccgttc tttttattac gttcgtatgg ggacatgctt tttcgaatga
     4921 atagcttggc cacaatccga aatcagctct caggcactct gattacaggt atattggatg
     4981 gcttcatgtt atttgtattg tctggttata tgttgttcat atctccattg cttgcgatgg
     5041 ttgtattttt gctggtaagc ataaatattt tgttggtcat tttcactaaa cgctatgtag
     5101 cagagattaa tcagcaacaa gtggtggcaa cgacagaggt gcaagctgtg cagacagaga
     5161 tgttgtacgg tattatggga gtaaaaatat cagggacaga acagcaagtt tactctcaat
     5221 ggcttaataa attcaagtat ttattgcagg tgtaccgccg aaaggaaaat ttgaatagct
     5281 acattacaac aactagcaat ggattgcagt ttatgtcacc actcattgtg ctaagtatcg
     5341 gcgttctgtt agttactggt aaatacagtt ctatgacggt tggtgagctt gtctcatttc
     5401 aagcaattgc gacgctactt tttactacat catcaagtct tatgaatacg ataaactcat
     5461 atattcttac gactactatt ctgaaaagaa cacatgacgt gctggaatct ccaattgagc
     5521 agaatgaagg taaattgcaa gtaaaagtaa gaggagatat tagactatca catgtcagct
     5581 tctcctattc gaagtatagt ccgaaggtga taaacgacat ttctttacat ataaagctag
     5641 ggcaaaagat agccattatt ggacaatctg gttctgggaa atcgacttta gctcatttga
     5701 tgattgggtt atttacacca acctcggggg aaatatacta tgataatcat gaaacctcgg
     5761 atttggatat gcaatatgtg cgtaaacaga tgggaatagt gccacaggat atatcattac
     5821 tcaatcgtag tatttatgat aacattgtcc tacaccagga tggtgtaact atggatgaag
     5881 tagtgcgggt ggcaaaagca gcgaatattc acgatgaaat tatggcgatg ccgatgaaat
     5941 atcagacagt tttggctgaa atgggcagga atatttcagg agggcaaaga caacgaatag
     6001 ctttggccag ggcactactt aataatccaa ccgtactagt attggatgaa gcaacgagcg
     6061 ctttggatca tataagtgaa gcgcgggtag atgaatattt atctagtatt aattgcacac
     6121 gaatagtgat agcccatcgg ttatcgacgg tgatgaatag cgacatgatc attgttttgg
     6181 agaatgggaa ggtttgcgat gtaggaaatc acagtcagtt gttacatact tcaaattatt
     6241 atcaatatta ctataaagaa atgagttcat agctgatttt tctttacagg ctgttcttaa
     6301 tgaattcatg aaatgaggct gtacttatat tgtaaggagt gggacaattg aaaacggtac
     6361 tatcggtgca acacctaacg aaagaaatta agggcaagat gattgtgcaa gacatatcat
     6421 tcgatgtggt agagggagag attattggac tacttggtgc gaacggagcg ggcaagacaa
     6481 ccactatgaa gatgatagtt ggtctaagca caataagttc cggggacgtg cagattgcag
     6541 gttacagtat taagagtcag ttttctaaag cactcttcaa tgtaggggca gtgattgaag
     6601 cacctgcatt ctatccttat ttgagtggat acgaaaattt acgtcaatat cagcgtttgc
     6661 acaaaaatgc gagtaaggat tggttgctgg aggtagccag tctaaccggt atagaacatg
     6721 cgcttaagca gcgagtaggc acgtactcca tgggaatgaa acaacgcttg ggaattgcac
     6781 aagcactact gcgaaagcca aagttgcttg tgttagatga gcctatgaat gcacttgatc
     6841 cttctggtgt ccgtgaaacc cggaactatt taaatagaat tgcggcagat ttgggcgtag
     6901 caattgtgat ttccagtcat caattgtctg agattgagca gatggcacgc cgagtggtta
     6961 ttatgcagaa tggctgctta gtgacagagc agcggattga tgatgggtta aatgatggga
     7021 aattctgtat cactctccac attgataatg ttgagcttac aagcgaagtt gtggttaact
     7081 tgtttgggga tgattatcat gcattggatt atatgcagac acagaaatta tctaacggtt
     7141 tgcatactat gacagtagct attgatgaag gtcaagttcc aaagctgatt cgagcattgt
     7201 gtgatgccgg ggtggaagtt catcgggtgt tgtcggcaca tacgagttta gaggataagt
     7261 ttttaaaatg gacaactgcg cgcggtgagg tgggttaaat tgttatggaa tgaatgtttg
     7321 aagatagtga ataaaagaat ctttattctt tcacacattg gttttattgt gatgacggta
     7381 ctgttctctt gggcatacac cagtaatctc aaggctgatg atacggtggc tcaaatggta
     7441 aatgctttgc ttggcctatc gggaatgctt gttattctac cttgggcgat tgttttgtca
     7501 cctcttattt ggacggatga gtatcaatat ggtactctga aacaactgtt tctgcatacg
     7561 tcttcgcgct cacggttgta tgttgcaaaa attactgcga tgattttgct catcattacg
     7621 agtgttgtta atatattcat tgtttctttg ttagtgaatc ttctgatggc tccaaaaaac
     7681 atacaatggg gcgacatgac ggatgttata tactctatcg gagcaatcgt attgcaatgt
     7741 tgcctatatg caagtctagc atccttgatt ggcgtgtgga cgagatcagc tgctatcgca
     7801 gtaggcggta gcttagtgct atacttttta caaatgatat ttggaggtag tctcttatct
     7861 acatcatgga cacacattct attcattcat catgatgatt taagtgttta ttggagcatg
     7921 tcacaatata aatcggaatt agttggcgta cctatatcgt tagcgataga tatcggctat
     7981 attttgtttt tctttgcaat tggattatgg ttgttcgtca aagagagagg agcagactaa
     8041 acataaaacg gagctaagaa tgagcaatat aggatacagt tatgtcattt atggcgatac
     8101 tcgggataac tgtatggaag acaaaataat gaatgtgaaa ctgaaagtag ccaataatga
     8161 taagtgacaa ttgattacgc tagtccaata aaccagcggc agtctaggac tttatttttg
     8221 tcaaagacta ccgttggttt taaatttaag tcagtctaac ttaattaaca gcggataggt
     8281 gtctgcaaat aacttatatc aatcagaagt tgtttacaaa gaaatatgtg attctaaaat
     8341 tgttgcgaaa ctaggcgttg catacagaaa gaagaatata aacccagatt tacaagagtt
     8401 tttgaaaata gcgaaaggca aggcgatgaa tacatttaca aaatgacgag aaaaatgaca
     8461 aaattgtaag aatacacgaa tgtttgtaag gaagttcgat gttttccttt ttcttttttt
     8521 attataatga aaaaaagaaa gaagaaggtg atggaaatgt catactcatg gtgataccta
     8581 tttttatgaa aataaaaaaa gcgtgggagg ggaagtaaga tgatgttttc tcagctcgcg
     8641 tttaaaaaca ttagtcgaaa tatacatacg tatgccgctt atttttcaag tgaaaacgtc
     8701 atgttagagt aagaaacagt acattcacat atttaagaag tagttaagtc tcatttaaac
     8761 ctttttttcc ataataaaat tataaacgta caagaaggtt ggtattttta gatgagtaca
     8821 ataatcaaaa ctattcatgt aatgaaggta tatggcaatc agttatacac cttactataa
     8881 aggagggatt tgaaaatgtc tttttctcaa ttcaatattg atatttttcg agcaattaat
     8941 gatttaggta aacaatattc attcctaaac tctgccatgg tatttttggc agaatatatg
     9001 gtatatattt tggctttaat tattatagct tattggttta ccggatccag aaaaagtagg
     9061 atgatggtta ttcaagcgat ggttgctttt gtgattgctg aggtgattgg aaaaatagca
     9121 gggaaatttc atttgaatta tcaaccgttt gcagtattgc ctgatgttaa taaacttgtc
     9181 gatcatgctg tagataattc atttcctagt gaccatacga ttctcttatt ttcgatttgt
     9241 ttttcgtttt ggcttgttcg taaaaagact ggatggttat ggcttatact tgcattttgt
     9301 gtagcgatct ctcgtatttg ggtaggagtt cattatcctt ttgatgttgc aataggggct
     9361 ttaatagggt gtgtttctgc gttattttcg tattggttag taccgaaatt ttcttttatc
     9421 aagcaattgc ttactctata tgaaagagta gagaaacgtg ttttaccatc caaaaacaaa
     9481 tcaaaggaat tttgagtata caagttagcg tgaaaaatac agatgctgac gacctatata
     9541 tgggatgtat tcatgttgca gctgttgctg aacaaattaa agagcaacaa cgaatgaaga
     9601 aggcttctta atcttttgtg tttgtggatg taataagcac ccaggttagg aagtgttgcg
     9661 gttctctttc ttcacaaagt aaatgtcaat taattacaaa atatacaata aaagttgatt
     9721 tttagagttt tttgtttact tcgctttttt cggcactcta cagctagatg gcaattattt
     9781 tgaccacagc aagactttat caatttcttc tttagtgttt aaattgatgt taggcagcgt
     9841 ttcaaacaaa taatgaatat aatgataggg acttagattg ttctcttttg cagtttccac
     9901 catacatgat ggcacttcct ctagcacctc acggtgtatt ttagaacatc caattcttcc
     9961 tcccgattac aaaggagtac tgacggcaaa acgcggattt tgtacgttaa tatatattct
    10021 aggagatgaa gctctgattt ttatagggtt ctgttgcgaa gttttgttaa ggttaagtgg
    10081 tgtcaacaaa aagttgtaca ttttatgcga ttgttagtag ctcctgtaat tcattgtatg
    10141 tcgaaaaacc gaagtctgag ccaagacttc ggtttcgttt atatttctct taatttgtta
    10201 aatgcgcaaa gtaatgctgg tgctttgtct gtagtgagaa ccgctggttc tccaaacgtt
    10261 ttaaccaatc ttttcataaa ggcataggca gcctgatgat cccgtttttt acgaagttga
    10321 atatccaatg tgtgcccgtc tttatcaatt gcacgatata aataacacca tattcctttg
    10381 acttttatat aggtttcatc tagttttcaa gataattgaa cgtttttatt tttcttcttc
    10441 caaatttgat agataaggtt tccgtattca tgaaccccgc gcatgatgat tgttgggtga
    10501 accgaaacac cacgctcttt caagatttcg gatacatcac gatagcttaa agaaaaacgg
    10561 taatactagc tgacggctac caaaataata tcctttttaa actgttttcc tttaaaatac
    10621 cccatatatc attctccttc tcctgctcac actttttcta caggttatct cagtttaaaa
    10681 atctttgcaa cagaaccgaa aacaccaatt gtatgttgaa tagaaaatag aatgttataa
    10741 atcaataaac aatcaatgta ataaaaatac agaagtttta tatagtgaca aattattttt
    10801 gggacagtat tttcttacat ctgatttcaa tacaatctag tttagatttt aaaaagaaaa
    10861 aatgttacaa atcgaacaac taaggctgaa ccctaaattc gtctataact aatatggaat
    10921 attttgtatt aatattcctt ttcgggggat gcttgcagaa aaagagttca aacaatgagg
    10981 gaggagaata ggaagccctg aagaataatt tgcattattt attccattta tggaaaaaca
    11041 aagattctca tcgacgcata attttttctg tttattgggt aatgtgtgat taaacttttt
    11101 ggaggggact attcatggtg agagtaaaat cgtatgaagt caatggggat tttccaacag
    11161 tgaaagatag gtgttaatcc aatataaact gcttttgaca aaaaaaccac ctccgtaaaa
    11221 agattgaaac ataaacagct taagcatagc caaattaagt taatttcaga cggaattcgg
    11281 atattcgtat caatttgtct cttaatataa aaaaagacaa ggatatcatt catccttgac
    11341 aggcttgtta tatattgaat tcaatggatc agtacctgga aacacatcta aaatttcttt
    11401 caagaagaat ttatgttctt taaatacaga catccaaacc gaaaacatcc cactctgttc
    11461 tacaagaagc ttaaacatct ctaatgctag actctctact tttgcttggg atagtagttg
    11521 acttttaaga gtattagcta gctcccattt ttcacgacgt tctaaagaac gtctgtcagc
    11581 tatttgagga ttctttttta gatcatcagt aacaatttta tttaatccga cgagattaat
    11641 tgtattagta gctttaactc tgtctgactt agataagtct ggtgagggtt taactattcc
    11701 accgtattac gtctaatcaa agctatacta tttatttttt aactgaatac accaagttca
    11761 tactacctta acgatgaacc ttaaaaaggc tttttattaa attatagtca agactagagg
    11821 gaagataaac aaaactctgt ttaatatccc tccactctgg aaaggagact tttatgatat
    11881 tctgatttta actaagattc cttgaggagt agagaaagta cttaagtaac ctattgcata
    11941 aagtctttcc gttaggtgct ataaacgctc ttttgctttt ttatgttaga gtacagagat
    12001 aaatgtctta tattgattcg gaaataatct gtaagttttc ttagctttgt tttaatgtta
    12061 ctttcgctta gcgaattttt catcaaagta ttcaacttca ccaaatcttc ctttgtaaaa
    12121 gccaaccttt cattttcatt tgtttatatt aaagtctaat tcctttcgtt cagttgctat
    12181 aaccaattca tctaaaaaga aatagccaat cagttgaagg ctatccttag ttcaaaaacc
    12241 ttttattttg ttttttaaaa ccgtatagag ttacatcaat aaataaatcg gcatctgtac
    12301 caccaactaa aaaaagagcc tacacctact caaatcagga atcataaact aaattcaaaa
    12361 atagtcatta aattttctaa gttcgcttaa aatttttcta ggttatctca atatatataa
    12421 tactctatgt ctaattcttt gtgttttgtt ggaactcttg gcactgttct aattttgttg
    12481 tttttatcct tactttatat aataatgtta cacttatcat taaacttgat ttaaagctct
    12541 ctgttgagag atttttgcat ttgataacat tatgttaaaa agtgattggg ttttgaccta
    12601 taatatatat agaattatta gcatataaca ataatctaaa gaatatgaca aatgctgaac
    12661 ggatgcagta tcttgtgtaa caagtgcctt tatcccttgt cagaacaggg gataatcgtg
    12721 ttttgagatg ttttaatata aaattataaa gggagtgatc acatggcaaa aagccaagcg
    12781 aaaaagaagc gggagcatcg attgagaaac ggcggacgtg acgtcttatt atcaagaggc
    12841 agcaaaccat ctttcagcac acatgaaaga atgacaagaa gcaaaaaaga gattttgaat
    12901 aaacggaagc ataagaatcc ttatgatcat acagcagttg atgataagga tttttttgtg
    12961 ccccaaaaag ccgcctagca ttcgtctcta tcgtttcttt ttgaaaaaag gcatgttttt
    13021 ccgtttcttt catacaatct attaaatcaa atcactagaa cgggtgggag gaaacggtat
    13081 gcgaaaaatc tcttataagg acatgtttct caggcatgtc aaagatcatc tctctcttta
    13141 tatatttgtg tcagtgctgt ttttcatggg tgtcatcttt ggcgcgatta ttgtcaacag
    13201 tatgaccatc agccagaaag aagatttata ctactactta agtcaatttt ttggacagct
    13261 ttcggatgga aaacaggcaa gttcagctga tatgtttggg caaagtatct ttcataatgc
    13321 aaagtattta ggcctgatgt ggatactggg aatttccgtc attgggatgc cgattatttt
    13381 cattatggtc tttctgaaag ggatcgtcgt cggctttact gtcgggttcc tagtcaatca
    13441 gatgggagta agcgggtttt tcctatcatt tgtctccgtt ttgccgcaaa atgtgctgct
    13501 gattccggct tatctcatta tgggcacatg tgcaattgcg ttttctttaa agttaatcag
    13561 acagctgttc gtgaaacgaa gcctgcatga cgcgccgatt caatggttcg ggcggtatgc
    13621 ctttgtgctg ctggtcattc tgtttttagc gctgatttca tctctctttg aagcatactt
    13681 atctcctgtt ttaatggaaa agcttacatc tagacttttt taaaattatt attaaaagaa
    13741 aaccgtttta tttatcagtt tataataatt atagttggaa ctctgcgcgt attttgttat
    13801 aatgagtcat ggaatgcggc gtaggaggga aagacatgga aaaccgtatt gatcgaatta
    13861 agaaacaact gcactcatcc agctataaac ttacgccaca gcgtgaagcg acagtaagag
    13921 tgctgcttga aaacgaagaa gaccatttaa gcgcagaaga tgtatacctc ctcgtaaaag
    13981 agaaatctcc tgagatcggt ctcgctacag tataccgtac gcttgaatta ttaactgaat
    14041 taaaagtcgt agataaaatt aactttggag acggtgtgtc ccgttacgac cttcgg
//
